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Conserved domains on  [gi|568910653|ref|XP_006496809|]
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tenascin-R isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 801-1010 4.36e-121

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


:

Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 368.91  E-value: 4.36e-121
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    801 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 880
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    881 NIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 958
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 568910653    959 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1010
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
233-423 3.45e-16

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 3.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  233 PGSRYEVSISAVRGTNESEASS----TQFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvl 307
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK-- 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  308 vpkgIGPTTKTTLTD--LVPGTEYGVGISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP- 379
Cdd:COG3401   279 ----VATVTTTSYTDtgLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAd 354

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 568910653  380 IDHYRIT-FTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITA 423
Cdd:COG3401   355 VTGYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
fn3 pfam00041
Fibronectin type III domain;
532-611 1.23e-13

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 1.23e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   532 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGRLDSSV-VPNTVTEFAITRLYPATEYEISLNSVRGRE 607
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568910653   608 ESER 611
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
83-163 1.68e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 1.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    83 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 158
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 568910653   159 RSPPT 163
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 709-794 1.13e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.05  E-value: 1.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  709 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 783
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 568910653  784 RS-SLTSTVFTT 794
Cdd:cd00063    82 ESpPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
443-522 1.89e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 1.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   443 PISHLHFSHVTSSSVNITWSdPSPPADRLILNYS----PRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTV 518
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWT-PPPDGNGPITGYEveyrPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568910653   519 TSEP 522
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
174-253 2.96e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 2.96e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   174 PTQILVRDVSDTVAFVEWTPPR---AKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNES 250
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 568910653   251 EAS 253
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
621-693 5.26e-07

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.18  E-value: 5.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   621 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIVLTHfaiAGE-----TILVDGVSEEFQLVDLLPSTHYTVTMYATS 692
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRP---KNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   .
gi 568910653   693 G 693
Cdd:pfam00041   78 G 78
 
Name Accession Description Interval E-value
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 801-1010 4.36e-121

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 368.91  E-value: 4.36e-121
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    801 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 880
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    881 NIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 958
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 568910653    959 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1010
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 801-1009 1.87e-120

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 367.34  E-value: 1.87e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  801 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 880
Cdd:cd00087     2 LPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  881 NIHRITAQGRYELRVDMRDG-QEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 959
Cdd:cd00087    81 KIHLLTSQGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCAE 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568910653  960 SYKGAWWYKNCHRTNLNGKYGESRH----SQGINWYHWKGHEFSIPFVEMKMRP 1009
Cdd:cd00087   161 SYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
802-1010 3.15e-99

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 311.38  E-value: 3.15e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   802 PQDCAQHLMNGDTLSGVYTIFLNGELShKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLE-DEFWLGLD 880
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGATK-PFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGND 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   881 NIHRITAQGRYELRVDMRDGQ-EAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-------SLSYHQGRPFSTEDRDNDV 952
Cdd:pfam00147   81 KIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDNDS 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568910653   953 AVTNCAMSYKGAWWYKNCHRTNLNGKY--GESRHSQ-GINWYHWKGHEFSIPFVEMKMRPY 1010
Cdd:pfam00147  161 PDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
233-423 3.45e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 3.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  233 PGSRYEVSISAVRGTNESEASS----TQFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvl 307
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK-- 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  308 vpkgIGPTTKTTLTD--LVPGTEYGVGISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP- 379
Cdd:COG3401   279 ----VATVTTTSYTDtgLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAd 354

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 568910653  380 IDHYRIT-FTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITA 423
Cdd:COG3401   355 VTGYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
fn3 pfam00041
Fibronectin type III domain;
354-433 2.57e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.98  E-value: 2.57e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   354 DSPRDLMVTASSETSISLIWTKA---SGPIDHYRITFTPSSGISS--EVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 428
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 568910653   429 QSLES 433
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
532-611 1.23e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 1.23e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   532 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGRLDSSV-VPNTVTEFAITRLYPATEYEISLNSVRGRE 607
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568910653   608 ESER 611
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 354-439 1.21e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  354 DSPRDLMVTASSETSISLIWTKAS---GPIDHYRITFTP-SSGISSEVTVPR-DRTSYTLTDLEPGAEYIISITAERGRQ 428
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREkGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 568910653  429 QSLESTVDAFT 439
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 354-430 1.95e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.79  E-value: 1.95e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    354 DSPRDLMVTASSETSISLIWTKAS-----GPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 428
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568910653    429 QS 430
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 532-610 5.05e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 5.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  532 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGR-LDSSVVPNTVTEFAITRLYPATEYEISLNSVRGRE 607
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ...
gi 568910653  608 ESE 610
Cdd:cd00063    82 ESP 84
fn3 pfam00041
Fibronectin type III domain;
83-163 1.68e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 1.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    83 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 158
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 568910653   159 RSPPT 163
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 709-794 1.13e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.05  E-value: 1.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  709 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 783
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 568910653  784 RS-SLTSTVFTT 794
Cdd:cd00063    82 ESpPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
443-522 1.89e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 1.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   443 PISHLHFSHVTSSSVNITWSdPSPPADRLILNYS----PRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTV 518
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWT-PPPDGNGPITGYEveyrPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568910653   519 TSEP 522
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
174-253 2.96e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 2.96e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   174 PTQILVRDVSDTVAFVEWTPPR---AKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNES 250
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 568910653   251 EAS 253
Cdd:pfam00041   83 PPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 709-778 3.83e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 3.83e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568910653    709 DPPDNLTASEVTRQSALISWQPPRAA-----IENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQA 778
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 532-609 9.04e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 9.04e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    532 DPPKNITISNVTKDSLTVSWSSP-----VAPFDYYRVSYRPTQVGRLDSSVVPNTvTEFAITRLYPATEYEISLNSVRGR 606
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSS-TSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 568910653    607 EES 609
Cdd:smart00060   81 GEG 83
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 805-844 2.22e-09

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 53.72  E-value: 2.22e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568910653  805 CAQ-HLMNGDTLSGVYTIFLNGELSHK-LQVYCDMTTDGGGW 844
Cdd:NF040941    2 CWEiLQAGPSAPSGVYWIDPDGMGGLApFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 83-170 7.20e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 7.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   83 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGV-IAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQA 158
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 568910653  159 RSPPTSASVSTV 170
Cdd:cd00063    82 ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
709-778 1.56e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.80  E-value: 1.56e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568910653   709 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSR--KELIVDAEDTWIRLEGLSENTDYTVLLQA 778
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 172-259 4.51e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 4.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  172 DGPTQILVRDVSDTVAFVEWTPPRAKVDFIL---LKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTN 248
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgyvVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 568910653  249 ESEAS-STQFTT 259
Cdd:cd00063    82 ESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 443-514 5.80e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 5.80e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568910653    443 PISHLHFSHVTSSSVNITWSDPSPPADRL-ILNYSPRDKEEDM--LEVLLDATKRHAVLMGLQPATEYIVNLVAV 514
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 443-529 1.04e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  443 PISHLHFSHVTSSSVNITWSDPSPPADRL---ILNYSPRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVT 519
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPItgyVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                          90
                  ....*....|.
gi 568910653  520 SEPI-VGSITT 529
Cdd:cd00063    83 SPPSeSVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
621-693 5.26e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.18  E-value: 5.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   621 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIVLTHfaiAGE-----TILVDGVSEEFQLVDLLPSTHYTVTMYATS 692
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRP---KNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   .
gi 568910653   693 G 693
Cdd:pfam00041   78 G 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 83-153 2.87e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 2.87e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568910653     83 STPQGLQFKTITETTVEVQWEPFSFSFDGW-EISFIPKNNEGG---VIAQLPSDVTSFNQTGLKPGEEYIVNVVA 153
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 172-250 1.40e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 1.40e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    172 DGPTQILVRDVSDTVAFVEWTPP-RAKVDFILLKYGLVGGEGGKTTFRL--QPPLSQYSVQALRPGSRYEVSISAVRGTN 248
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568910653    249 ES 250
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 621-693 1.77e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 1.77e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568910653    621 DSPMDLIATNITPTEALLQWKAP-----MGEVENYVIVLTHFAIAGETILVDGVSEEFQLVDLLPSTHYTVTMYATSG 693
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 621-702 9.57e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 9.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  621 DSPMDLIATNITPTEALLQWKAP---MGEVENYVIVLT-HFAIAGETILVDGVSE-EFQLVDLLPSTHYTVTMYA----- 690
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYReKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAvnggg 81

                          90
                  ....*....|..
gi 568910653  691 TSGPLMSGTIAT 702
Cdd:cd00063    82 ESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 801-1010 4.36e-121

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 368.91  E-value: 4.36e-121
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    801 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 880
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    881 NIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 958
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 568910653    959 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1010
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 801-1009 1.87e-120

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 367.34  E-value: 1.87e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  801 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 880
Cdd:cd00087     2 LPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  881 NIHRITAQGRYELRVDMRDG-QEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 959
Cdd:cd00087    81 KIHLLTSQGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCAE 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568910653  960 SYKGAWWYKNCHRTNLNGKYGESRH----SQGINWYHWKGHEFSIPFVEMKMRP 1009
Cdd:cd00087   161 SYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
802-1010 3.15e-99

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 311.38  E-value: 3.15e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   802 PQDCAQHLMNGDTLSGVYTIFLNGELShKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLE-DEFWLGLD 880
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGATK-PFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGND 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   881 NIHRITAQGRYELRVDMRDGQ-EAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-------SLSYHQGRPFSTEDRDNDV 952
Cdd:pfam00147   81 KIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDNDS 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568910653   953 AVTNCAMSYKGAWWYKNCHRTNLNGKY--GESRHSQ-GINWYHWKGHEFSIPFVEMKMRPY 1010
Cdd:pfam00147  161 PDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
233-423 3.45e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 3.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  233 PGSRYEVSISAVRGTNESEASS----TQFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvl 307
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK-- 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  308 vpkgIGPTTKTTLTD--LVPGTEYGVGISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP- 379
Cdd:COG3401   279 ----VATVTTTSYTDtgLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAd 354

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 568910653  380 IDHYRIT-FTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITA 423
Cdd:COG3401   355 VTGYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
fn3 pfam00041
Fibronectin type III domain;
354-433 2.57e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.98  E-value: 2.57e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   354 DSPRDLMVTASSETSISLIWTKA---SGPIDHYRITFTPSSGISS--EVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 428
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 568910653   429 QSLES 433
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
532-611 1.23e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 1.23e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   532 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGRLDSSV-VPNTVTEFAITRLYPATEYEISLNSVRGRE 607
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568910653   608 ESER 611
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 354-439 1.21e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  354 DSPRDLMVTASSETSISLIWTKAS---GPIDHYRITFTP-SSGISSEVTVPR-DRTSYTLTDLEPGAEYIISITAERGRQ 428
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREkGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 568910653  429 QSLESTVDAFT 439
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 354-430 1.95e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.79  E-value: 1.95e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    354 DSPRDLMVTASSETSISLIWTKAS-----GPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 428
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568910653    429 QS 430
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 532-610 5.05e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 5.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  532 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGR-LDSSVVPNTVTEFAITRLYPATEYEISLNSVRGRE 607
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ...
gi 568910653  608 ESE 610
Cdd:cd00063    82 ESP 84
fn3 pfam00041
Fibronectin type III domain;
83-163 1.68e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 1.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    83 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 158
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 568910653   159 RSPPT 163
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 709-794 1.13e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.05  E-value: 1.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  709 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 783
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 568910653  784 RS-SLTSTVFTT 794
Cdd:cd00063    82 ESpPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
443-522 1.89e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 1.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   443 PISHLHFSHVTSSSVNITWSdPSPPADRLILNYS----PRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTV 518
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWT-PPPDGNGPITGYEveyrPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568910653   519 TSEP 522
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
174-253 2.96e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 2.96e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   174 PTQILVRDVSDTVAFVEWTPPR---AKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNES 250
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 568910653   251 EAS 253
Cdd:pfam00041   83 PPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 709-778 3.83e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 3.83e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568910653    709 DPPDNLTASEVTRQSALISWQPPRAA-----IENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQA 778
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 532-609 9.04e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 9.04e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    532 DPPKNITISNVTKDSLTVSWSSP-----VAPFDYYRVSYRPTQVGRLDSSVVPNTvTEFAITRLYPATEYEISLNSVRGR 606
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSS-TSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 568910653    607 EES 609
Cdd:smart00060   81 GEG 83
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 805-844 2.22e-09

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 53.72  E-value: 2.22e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568910653  805 CAQ-HLMNGDTLSGVYTIFLNGELSHK-LQVYCDMTTDGGGW 844
Cdd:NF040941    2 CWEiLQAGPSAPSGVYWIDPDGMGGLApFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 262-346 3.67e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.81  E-value: 3.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  262 DAPKNLRVGSRTATSLDLEWD---NSEAEAQEYKVVYSTLAGEQYHEVlvPKGIGPTTKTTLTDLVPGTEYGVGISAVMN 338
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTppeDDGGPITGYVVEYREKGSGDWKEV--EVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79


                  ....*...
gi 568910653  339 SKQSIPAT 346
Cdd:cd00063    80 GGESPPSE 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 83-170 7.20e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 7.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   83 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGV-IAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQA 158
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 568910653  159 RSPPTSASVSTV 170
Cdd:cd00063    82 ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
709-778 1.56e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.80  E-value: 1.56e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568910653   709 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSR--KELIVDAEDTWIRLEGLSENTDYTVLLQA 778
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 172-259 4.51e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 4.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  172 DGPTQILVRDVSDTVAFVEWTPPRAKVDFIL---LKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTN 248
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgyvVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 568910653  249 ESEAS-STQFTT 259
Cdd:cd00063    82 ESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 443-514 5.80e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 5.80e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568910653    443 PISHLHFSHVTSSSVNITWSDPSPPADRL-ILNYSPRDKEEDM--LEVLLDATKRHAVLMGLQPATEYIVNLVAV 514
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 262-336 9.93e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 9.93e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568910653    262 DAPKNLRVGSRTATSLDLEWDNSEAEAQE-YKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAV 336
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 443-529 1.04e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  443 PISHLHFSHVTSSSVNITWSDPSPPADRL---ILNYSPRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVT 519
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPItgyVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                          90
                  ....*....|.
gi 568910653  520 SEPI-VGSITT 529
Cdd:cd00063    83 SPPSeSVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
262-336 2.31e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 2.31e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568910653   262 DAPKNLRVGSRTATSLDLEW---DNSEAEAQEYKVVYSTLAGEQY-HEVLVPkgiGPTTKTTLTDLVPGTEYGVGISAV 336
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPwNEITVP---GTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
621-693 5.26e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.18  E-value: 5.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   621 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIVLTHfaiAGE-----TILVDGVSEEFQLVDLLPSTHYTVTMYATS 692
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRP---KNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   .
gi 568910653   693 G 693
Cdd:pfam00041   78 G 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 83-153 2.87e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 2.87e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568910653     83 STPQGLQFKTITETTVEVQWEPFSFSFDGW-EISFIPKNNEGG---VIAQLPSDVTSFNQTGLKPGEEYIVNVVA 153
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 172-250 1.40e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 1.40e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653    172 DGPTQILVRDVSDTVAFVEWTPP-RAKVDFILLKYGLVGGEGGKTTFRL--QPPLSQYSVQALRPGSRYEVSISAVRGTN 248
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568910653    249 ES 250
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 621-693 1.77e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 1.77e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568910653    621 DSPMDLIATNITPTEALLQWKAP-----MGEVENYVIVLTHFAIAGETILVDGVSEEFQLVDLLPSTHYTVTMYATSG 693
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 621-702 9.57e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 9.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  621 DSPMDLIATNITPTEALLQWKAP---MGEVENYVIVLT-HFAIAGETILVDGVSE-EFQLVDLLPSTHYTVTMYA----- 690
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYReKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAvnggg 81

                          90
                  ....*....|..
gi 568910653  691 TSGPLMSGTIAT 702
Cdd:cd00063    82 ESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
37-339 2.10e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 45.38  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653   37 QQRVPGDWSGVTIMELEPGLTYNISVYAVISNILSLPITAKVATHLST----PQGLQFKTITETTVEVQWEP-FSFSFDG 111
Cdd:COG3401   184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTppsaPTGLTATADTPGSVTLSWDPvTESDATG 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  112 WEISFipKNNEGGVIAQLPS-DVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVIDG-----PTQILVRDVSDT 185
Cdd:COG3401   264 YRVYR--SNSGDGPFTKVATvTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLtppaaPSGLTATAVGSS 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  186 VAFVEWTPP-----------RAKVDFilLKYGLVGGEGGKTTFR---LQPPLS-QYSVQALRPGSRYEVSISAVRGTNES 250
Cdd:COG3401   342 SITLSWTASsdadvtgynvyRSTSGG--GTYTKIAETVTTTSYTdtgLTPGTTyYYKVTAVDAAGNESAPSEEVSATTAS 419

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910653  251 EASSTQFTTEIDAPKNLRVGSRTATSLDLEWDNSeaEAQEYKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYG 330
Cdd:COG3401   420 AASGESLTASVDAVPLTDVAGATAAASAASNPGV--SAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497


                  ....*....
gi 568910653  331 VGISAVMNS 339
Cdd:COG3401   498 GGSGASSVT 506
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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