NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568905811|ref|XP_006495773|]
View 

interleukin-18 receptor accessory protein isoform X1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 36-164 1.02e-63

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


:

Pssm-ID: 465773  Cd Length: 128  Bit Score: 204.57  E-value: 1.02e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811   36 ARGAENFVLFCDLQELQEQKFSHASQLSPTQSPaHKPCSGSqKDLSDVQWYMQPRSGSPLEEISRNSPHM-QSEGMLHIL 114
Cdd:pfam18452   1 ARSEEEFVLFCDLPEPQKTHFYHRSQLSPTQGP-HLPCSGS-KDLSDVQWYWQPKNGDPLEAITESSPHIiQEGNALWFL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 568905811  115 APQTNSIWSYICRPRIRSPQDMACCIKTVLEVKPQRNVSCGNTAQDEQVL 164
Cdd:pfam18452  79 PVGVNDSGSYICRPRIRSPQDEACCLKIILEVQPKTNASCSGSVTNELYL 128
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 364-512 2.93e-38

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


:

Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 138.27  E-value: 2.93e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811  364 FVSYSNwsspetdAVGSLSEEHLALNLFPEVleDTYGYRLCLLDRDVTPGGVYADDIVSIIKKSRRGIFILSPSYLNGP- 442
Cdd:pfam01582   1 YDVFLS-------FRGSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGw 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811  443 RVFELQAAVNLALvDQTLKLILIKFCSFQEPE-----SLPYLVKKALRVL---PTVTWKGL----------KSVHASSRF 504
Cdd:pfam01582  72 CLDELVKILECAL-DLGQKVIPIFYEVDPSDVrkqtgSFGKAFKKHKKVLteeKVLKWRGAlnevaniwhsKSVSDESKF 150


                  ....*...
gi 568905811  505 WTQIRYHM 512
Cdd:pfam01582 151 WKKIAYDI 158
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 263-353 9.41e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd20931:

Pssm-ID: 472250  Cd Length: 107  Bit Score: 44.63  E-value: 9.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811 263 ELGKPLTLPCRVQFGFQRLSKPVIKWYV---KESTQEWEMSVFEEKRIQSTfKNEVIERTIFLREVTQRDLSRKFVCFAQ 339
Cdd:cd20931   15 EPGEELLIPCTVYFSFLMDSRNEVWWTIdgkKPDDVTIDVTINESISYSST-EDETRTQILSIKKVTPEDLKRNYVCHAR 93

                         90
                 ....*....|....
gi 568905811 340 NSIGNTTRTIRLRK 353
Cdd:cd20931   94 NAKGEVEKAAKVKQ 107
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 162-243 1.86e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05757:

Pssm-ID: 472250  Cd Length: 92  Bit Score: 37.69  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811 162 QVLLLGSTGSIHCPSLSCQSDV-QSPEMTWYKDGRLLPEHKKNPIEMADIYVFN-----QGLYVCDYTQSDNVSSWTVRA 235
Cdd:cd05757    5 QKLPITKGGKITCPDLDDYKNEnVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNvteedAGNYTCKFTYTHNGKQYNVTR 84


                 ....*...
gi 568905811 236 VVKVRTIG 243
Cdd:cd05757   85 TISLTVTE 92
 
Name Accession Description Interval E-value
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 36-164 1.02e-63

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 204.57  E-value: 1.02e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811   36 ARGAENFVLFCDLQELQEQKFSHASQLSPTQSPaHKPCSGSqKDLSDVQWYMQPRSGSPLEEISRNSPHM-QSEGMLHIL 114
Cdd:pfam18452   1 ARSEEEFVLFCDLPEPQKTHFYHRSQLSPTQGP-HLPCSGS-KDLSDVQWYWQPKNGDPLEAITESSPHIiQEGNALWFL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 568905811  115 APQTNSIWSYICRPRIRSPQDMACCIKTVLEVKPQRNVSCGNTAQDEQVL 164
Cdd:pfam18452  79 PVGVNDSGSYICRPRIRSPQDEACCLKIILEVQPKTNASCSGSVTNELYL 128
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 364-512 2.93e-38

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 138.27  E-value: 2.93e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811  364 FVSYSNwsspetdAVGSLSEEHLALNLFPEVleDTYGYRLCLLDRDVTPGGVYADDIVSIIKKSRRGIFILSPSYLNGP- 442
Cdd:pfam01582   1 YDVFLS-------FRGSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGw 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811  443 RVFELQAAVNLALvDQTLKLILIKFCSFQEPE-----SLPYLVKKALRVL---PTVTWKGL----------KSVHASSRF 504
Cdd:pfam01582  72 CLDELVKILECAL-DLGQKVIPIFYEVDPSDVrkqtgSFGKAFKKHKKVLteeKVLKWRGAlnevaniwhsKSVSDESKF 150


                  ....*...
gi 568905811  505 WTQIRYHM 512
Cdd:pfam01582 151 WKKIAYDI 158
TIR smart00255
Toll - interleukin 1 - resistance;
360-515 1.23e-27

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 108.18  E-value: 1.23e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811   360 EFDAFVSYSnwsspetdavgslSEEHLALNLFPEVLEDTYGYRLCLLDRDVTPGGVYADDIVSIIKKSRRGIFILSPSYL 439
Cdd:smart00255   1 EYDVFISYS-------------GKEDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYA 67

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568905811   440 NGPRV-FELQAAVNLALVDQTLKLILIKFCSF-QEPESLPYLVKKALRVlPTVTWKGLKSVhassRFWTQIRYHMPVK 515
Cdd:smart00255  68 ESEWClDELVAALENALEEGGLRVIPIFYEVIpSDVRKQPGKFRKVFKK-NYLKWPEDEKE----QFWKKALYAVPSK 140
Ig3_IL1RAP cd20931
Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members ...
 263-353 9.41e-06

Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members here are composed of the third immunoglobulin Ig interleukin-1 receptor accessory protein (IL1RAP). The interleukin 1 receptor accessory protein (IL-1RAP), also known as IL-1R3, is a coreceptor of type 1 interleukin 1 receptor (IL-1R1) and is required for transmission of IL-1 signaling. The activated IL-1 receptor complex, which consists of IL-1R1 and IL-1RAP, induces multiple cellular responses including NF-kappa-B activation, IL-2 secretion, and IL-2 promoter activation. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective Toll/IL-1 receptor (TIR) domains of the receptor/coreceptor subunits. Moreover, IL1RAP is known to be the accessory co-receptor that activates signal transduction upon IL-36 binding to IL-36R. IL-36 cytokines, which are a subfamily of the IL-1 superfamily, bind to the IL-36 receptor (IL-36R) and use IL1RAP as a co-receptor.


Pssm-ID: 409525  Cd Length: 107  Bit Score: 44.63  E-value: 9.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811 263 ELGKPLTLPCRVQFGFQRLSKPVIKWYV---KESTQEWEMSVFEEKRIQSTfKNEVIERTIFLREVTQRDLSRKFVCFAQ 339
Cdd:cd20931   15 EPGEELLIPCTVYFSFLMDSRNEVWWTIdgkKPDDVTIDVTINESISYSST-EDETRTQILSIKKVTPEDLKRNYVCHAR 93

                         90
                 ....*....|....
gi 568905811 340 NSIGNTTRTIRLRK 353
Cdd:cd20931   94 NAKGEVEKAAKVKQ 107
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 262-352 2.81e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.80  E-value: 2.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811   262 VELGKPLTLPCRVQfGFqrlSKPVIKWYvKESTQEwemsVFEEKRIQSTFKNEviERTIFLREVTQRDlSRKFVCFAQNS 341
Cdd:smart00410   6 VKEGESVTLSCEAS-GS---PPPEVTWY-KQGGKL----LAESGRFSVSRSGS--TSTLTISNVTPED-SGTYTCAATNS 73

                           90
                   ....*....|.
gi 568905811   342 IGNTTRTIRLR 352
Cdd:smart00410  74 SGSASSGTTLT 84
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 162-243 1.86e-03

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 37.69  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811 162 QVLLLGSTGSIHCPSLSCQSDV-QSPEMTWYKDGRLLPEHKKNPIEMADIYVFN-----QGLYVCDYTQSDNVSSWTVRA 235
Cdd:cd05757    5 QKLPITKGGKITCPDLDDYKNEnVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNvteedAGNYTCKFTYTHNGKQYNVTR 84


                 ....*...
gi 568905811 236 VVKVRTIG 243
Cdd:cd05757   85 TISLTVTE 92
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 255-351 2.67e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 37.17  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811  255 PITDTLDVELGKPLTLPCRVQFGfqrLSKPVIKWYVKESTQEWEMSVFEEKRIQSTFknevierTIFLREVTQRDlSRKF 334
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTG---SPGPDVTWSKEGGTLIESLKVKHDNGRTTQS-------SLLISNVTKED-AGTY 69

                          90
                  ....*....|....*..
gi 568905811  335 VCFAQNSIGNTTRTIRL 351
Cdd:pfam00047  70 TCVVNNPGGSATLSTSL 86
 
Name Accession Description Interval E-value
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 36-164 1.02e-63

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 204.57  E-value: 1.02e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811   36 ARGAENFVLFCDLQELQEQKFSHASQLSPTQSPaHKPCSGSqKDLSDVQWYMQPRSGSPLEEISRNSPHM-QSEGMLHIL 114
Cdd:pfam18452   1 ARSEEEFVLFCDLPEPQKTHFYHRSQLSPTQGP-HLPCSGS-KDLSDVQWYWQPKNGDPLEAITESSPHIiQEGNALWFL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 568905811  115 APQTNSIWSYICRPRIRSPQDMACCIKTVLEVKPQRNVSCGNTAQDEQVL 164
Cdd:pfam18452  79 PVGVNDSGSYICRPRIRSPQDEACCLKIILEVQPKTNASCSGSVTNELYL 128
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 364-512 2.93e-38

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 138.27  E-value: 2.93e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811  364 FVSYSNwsspetdAVGSLSEEHLALNLFPEVleDTYGYRLCLLDRDVTPGGVYADDIVSIIKKSRRGIFILSPSYLNGP- 442
Cdd:pfam01582   1 YDVFLS-------FRGSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGw 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811  443 RVFELQAAVNLALvDQTLKLILIKFCSFQEPE-----SLPYLVKKALRVL---PTVTWKGL----------KSVHASSRF 504
Cdd:pfam01582  72 CLDELVKILECAL-DLGQKVIPIFYEVDPSDVrkqtgSFGKAFKKHKKVLteeKVLKWRGAlnevaniwhsKSVSDESKF 150


                  ....*...
gi 568905811  505 WTQIRYHM 512
Cdd:pfam01582 151 WKKIAYDI 158
TIR smart00255
Toll - interleukin 1 - resistance;
360-515 1.23e-27

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 108.18  E-value: 1.23e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811   360 EFDAFVSYSnwsspetdavgslSEEHLALNLFPEVLEDTYGYRLCLLDRDVTPGGVYADDIVSIIKKSRRGIFILSPSYL 439
Cdd:smart00255   1 EYDVFISYS-------------GKEDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYA 67

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568905811   440 NGPRV-FELQAAVNLALVDQTLKLILIKFCSF-QEPESLPYLVKKALRVlPTVTWKGLKSVhassRFWTQIRYHMPVK 515
Cdd:smart00255  68 ESEWClDELVAALENALEEGGLRVIPIFYEVIpSDVRKQPGKFRKVFKK-NYLKWPEDEKE----QFWKKALYAVPSK 140
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 364-460 1.93e-06

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 46.92  E-value: 1.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811  364 FVSYSnwsSPETDAVgslseEHLAlnlfpEVLEDtYGYRlCLLDR-DVTPGGVYADDIVSIIKKSRRGIFILSPSYLNGP 442
Cdd:pfam13676   2 FISYA---GEDRAWA-----EWLA-----DALEA-AGYR-VWLDRwDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESP 66

                          90
                  ....*....|....*....
gi 568905811  443 RV-FELQAAVNLALVDQTL 460
Cdd:pfam13676  67 WCrAEWEAALADPEGRKRL 85
Ig3_IL1RAP cd20931
Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members ...
 263-353 9.41e-06

Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members here are composed of the third immunoglobulin Ig interleukin-1 receptor accessory protein (IL1RAP). The interleukin 1 receptor accessory protein (IL-1RAP), also known as IL-1R3, is a coreceptor of type 1 interleukin 1 receptor (IL-1R1) and is required for transmission of IL-1 signaling. The activated IL-1 receptor complex, which consists of IL-1R1 and IL-1RAP, induces multiple cellular responses including NF-kappa-B activation, IL-2 secretion, and IL-2 promoter activation. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective Toll/IL-1 receptor (TIR) domains of the receptor/coreceptor subunits. Moreover, IL1RAP is known to be the accessory co-receptor that activates signal transduction upon IL-36 binding to IL-36R. IL-36 cytokines, which are a subfamily of the IL-1 superfamily, bind to the IL-36 receptor (IL-36R) and use IL1RAP as a co-receptor.


Pssm-ID: 409525  Cd Length: 107  Bit Score: 44.63  E-value: 9.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811 263 ELGKPLTLPCRVQFGFQRLSKPVIKWYV---KESTQEWEMSVFEEKRIQSTfKNEVIERTIFLREVTQRDLSRKFVCFAQ 339
Cdd:cd20931   15 EPGEELLIPCTVYFSFLMDSRNEVWWTIdgkKPDDVTIDVTINESISYSST-EDETRTQILSIKKVTPEDLKRNYVCHAR 93

                         90
                 ....*....|....
gi 568905811 340 NSIGNTTRTIRLRK 353
Cdd:cd20931   94 NAKGEVEKAAKVKQ 107
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 262-352 2.81e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.80  E-value: 2.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811   262 VELGKPLTLPCRVQfGFqrlSKPVIKWYvKESTQEwemsVFEEKRIQSTFKNEviERTIFLREVTQRDlSRKFVCFAQNS 341
Cdd:smart00410   6 VKEGESVTLSCEAS-GS---PPPEVTWY-KQGGKL----LAESGRFSVSRSGS--TSTLTISNVTPED-SGTYTCAATNS 73

                           90
                   ....*....|.
gi 568905811   342 IGNTTRTIRLR 352
Cdd:smart00410  74 SGSASSGTTLT 84
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 162-243 1.86e-03

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 37.69  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811 162 QVLLLGSTGSIHCPSLSCQSDV-QSPEMTWYKDGRLLPEHKKNPIEMADIYVFN-----QGLYVCDYTQSDNVSSWTVRA 235
Cdd:cd05757    5 QKLPITKGGKITCPDLDDYKNEnVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNvteedAGNYTCKFTYTHNGKQYNVTR 84


                 ....*...
gi 568905811 236 VVKVRTIG 243
Cdd:cd05757   85 TISLTVTE 92
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 255-351 2.67e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 37.17  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905811  255 PITDTLDVELGKPLTLPCRVQFGfqrLSKPVIKWYVKESTQEWEMSVFEEKRIQSTFknevierTIFLREVTQRDlSRKF 334
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTG---SPGPDVTWSKEGGTLIESLKVKHDNGRTTQS-------SLLISNVTKED-AGTY 69

                          90
                  ....*....|....*..
gi 568905811  335 VCFAQNSIGNTTRTIRL 351
Cdd:pfam00047  70 TCVVNNPGGSATLSTSL 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH