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Conserved domains on  [gi|568905790|ref|XP_006495763|]
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fibronectin isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 4.24e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.60  E-value: 4.24e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 568905790    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 1.61e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 95.06  E-value: 1.61e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 568905790    413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
fn3 pfam00041
Fibronectin type III domain;
1541-1620 2.29e-19

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.39  E-value: 2.29e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1541 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1617
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 568905790  1618 PAS 1620
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
1633-1713 4.83e-18

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 80.92  E-value: 4.83e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  1710 ESQP 1713
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1470 7.48e-18

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 90.06  E-value: 7.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTAGLTRGGQPKQYNVGPLASKYPLRNLQPG--SEYTVTLVAVKG 1070
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSpaVGTATTATAVAG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1071 NQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGgeapreVTSDSGSIVVSGLTPGVEYTY 1150
Cdd:COG3401   134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT------VTSTTLVDGGGDIEPGTTYYY 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1151 TIQVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVvhaD 1227
Cdd:COG3401   208 RVAATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---T 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1228 QSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-------VPEVPQltDLSFVDITDSSIGLRWTPLNSSTIIGYRIT 1300
Cdd:COG3401   284 TTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdltPPAAPS--GLTATAVGSSSITLSWTASSDADVTGYNVY 361

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1301 VVAAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTAVPPPTDLRFTNiGPDTMRVTW 1377
Cdd:COG3401   362 RSTSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTA-SVDAVPLTD 437

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1378 APPPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGLDSPTGFDSS 1457
Cdd:COG3401   438 VAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517

                         490
                  ....*....|...
gi 568905790 1458 DITANSFTVHWVA 1470
Cdd:COG3401   518 AAVGGAPDGTPNV 530
fn3 pfam00041
Fibronectin type III domain;
1449-1529 3.80e-17

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 78.23  E-value: 3.80e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1449 DSPTGFDSSDITANSFTVHWVAPR---APITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGRE 1525
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  1526 ESPP 1529
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1994-2074 1.06e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1994 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2070
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 568905790 2071 KSEP 2074
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 9.47e-16

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 9.47e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568905790   811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 4.18e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.23  E-value: 4.18e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
232-271 1.05e-14

Fibronectin type I domain;


:

Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.65  E-value: 1.05e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2221-2262 1.26e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.26e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568905790   2221 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2262
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
fn3 pfam00041
Fibronectin type III domain;
1813-1893 1.42e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1813 PAPTNLKFSQVTPTSFTAQWIAP---SVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1889
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  1890 TSRP 1893
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2176-2220 2.01e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 2.01e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790   2176 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRCDSSKW 2220
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 2.97e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 2.97e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 3.72e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.72e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1905-1984 9.06e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.60  E-value: 9.06e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1905 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1980
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  1981 RSSP 1984
Cdd:pfam00041   81 EGPP 84
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
698-1027 9.18e-14

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 9.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  698 TTSASTPVTSNTVTGETAPYSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401   212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401   290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWT 927
Cdd:COG3401   370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  928 PPDSVVSGYRVEVLPVSLPgehgqrlPVNRNTFAEITGLSPGVTYLFKVFAVHQGRESNPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401   450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                         330       340
                  ....*....|....*....|
gi 568905790 1008 TDRTVLVTWTPPRARIAGYR 1027
Cdd:COG3401   523 APDGTPNVTGASPVTVGAST 542
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 1.92e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.22  E-value: 1.92e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 5.20e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 62.37  E-value: 5.20e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790     98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2264-2303 7.73e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 7.73e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568905790 2264 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2303
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
619-688 1.10e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 1.10e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568905790   619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 1.35e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.21  E-value: 1.35e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568905790    142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 4.95e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 4.95e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 568905790   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1723-1803 1.14e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1723 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIRELFPAPDGEDDTAELQGLRPGSEYTVSVVALHDDM 1799
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 568905790 1800 ESQP 1803
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
2090-2145 8.02e-07

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 8.02e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  2090 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEAL 2145
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 2.35e-05

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 43.49  E-value: 2.35e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    308 CVTD-SGVVYSVGMQWLKSQGNKQML-CTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 4.24e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.60  E-value: 4.24e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 568905790    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 1.61e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 95.06  E-value: 1.61e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 568905790    413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 354-401 1.73e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 1.73e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 568905790  354 NSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 414-461 2.12e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 2.12e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 568905790  414 NSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
360-401 1.75e-20

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 86.08  E-value: 1.75e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568905790   360 CVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1541-1620 2.29e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.39  E-value: 2.29e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1541 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1617
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 568905790  1618 PAS 1620
Cdd:pfam00041   83 PPS 85
fn2 pfam00040
Fibronectin type II domain;
420-461 3.96e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 82.23  E-value: 3.96e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568905790   420 CHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1633-1713 4.83e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 80.92  E-value: 4.83e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  1710 ESQP 1713
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1470 7.48e-18

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 90.06  E-value: 7.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTAGLTRGGQPKQYNVGPLASKYPLRNLQPG--SEYTVTLVAVKG 1070
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSpaVGTATTATAVAG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1071 NQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGgeapreVTSDSGSIVVSGLTPGVEYTY 1150
Cdd:COG3401   134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT------VTSTTLVDGGGDIEPGTTYYY 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1151 TIQVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVvhaD 1227
Cdd:COG3401   208 RVAATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---T 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1228 QSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-------VPEVPQltDLSFVDITDSSIGLRWTPLNSSTIIGYRIT 1300
Cdd:COG3401   284 TTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdltPPAAPS--GLTATAVGSSSITLSWTASSDADVTGYNVY 361

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1301 VVAAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTAVPPPTDLRFTNiGPDTMRVTW 1377
Cdd:COG3401   362 RSTSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTA-SVDAVPLTD 437

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1378 APPPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGLDSPTGFDSS 1457
Cdd:COG3401   438 VAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517

                         490
                  ....*....|...
gi 568905790 1458 DITANSFTVHWVA 1470
Cdd:COG3401   518 AAVGGAPDGTPNV 530
fn3 pfam00041
Fibronectin type III domain;
1449-1529 3.80e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 78.23  E-value: 3.80e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1449 DSPTGFDSSDITANSFTVHWVAPR---APITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGRE 1525
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  1526 ESPP 1529
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1994-2074 1.06e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1994 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2070
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 568905790 2071 KSEP 2074
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 9.47e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 9.47e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568905790   811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1358-1439 1.93e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 1.93e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1358 PPPTDLRFTNIGPDTMRVTWAPPP--SIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  1436 ESIP 1439
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1994-2074 2.37e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.37e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1994 DAPSNLRFLTTTPNSLLVSWQAPRAR---ITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2070
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  2071 KSEP 2074
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 810-898 2.81e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.30  E-value: 2.81e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  810 PDAPPDPTVDQVDDTSIVVRWSRPQ---APITGYRIVYSPSVEGSSTELNLPE-TANSVTLSDLQPGVQYNITIYAVEEN 885
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 568905790  886 QESTPVFIQQETT 898
Cdd:cd00063    81 GESPPSESVTVTT 93
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 4.18e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.23  E-value: 4.18e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
232-271 1.05e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.65  E-value: 1.05e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 232-275 1.15e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.15e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568905790    232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERHA 275
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2221-2262 1.26e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.26e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568905790   2221 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2262
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1240-1758 1.41e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 79.66  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1240 LEYNVSVYTVKDDKESAPISDTVVPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSV 1319
Cdd:COG3401    22 AVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1320 GYYTVTGlePGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTWAPPPSIE-LTNLLVRYSPVKNE 1398
Cdd:COG3401   102 SVGGATN--TGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAgAGVVVSPDTSATAA 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1399 EDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGL----DSPTGFDSSDITANSFTVHWVAPRAP 1474
Cdd:COG3401   180 VATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPVTES 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1475 -ITGYII-RHHAEHS----VGRPRQdrvppsrNSITLTNLNPGTEYVVSIIAVNGR-EESPPLIGQQATVSDI----PRD 1543
Cdd:COG3401   260 dATGYRVyRSNSGDGpftkVATVTT-------TSYTDTGLTNGTTYYYRVTAVDAAgNESAPSNVVSVTTDLTppaaPSG 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1544 LEVIASTPTSLLISWEPPA-VSVRYYRItYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSK 1622
Cdd:COG3401   333 LTATAVGSSSITLSWTASSdADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSE 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1623 PVSINYKTEIDKPSQMQVTDVQDNSISVRWLPSTSPVTGYRVTTTP----------KNGLGPSKTKTASPDQTEMTIEGL 1692
Cdd:COG3401   412 EVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVladggdtgnaVPFTTTSSTVTATTTDTTTANLSV 491

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568905790 1693 QPTVEYVVSVYAQNRNGES-QPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSS 1758
Cdd:COG3401   492 TTGSLVGGSGASSVTNSVSvIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSAS 558
fn3 pfam00041
Fibronectin type III domain;
1813-1893 1.42e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1813 PAPTNLKFSQVTPTSFTAQWIAP---SVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1889
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  1890 TSRP 1893
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2176-2220 2.01e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 2.01e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790   2176 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRCDSSKW 2220
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 2.97e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 2.97e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 3.72e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.72e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1449-1529 5.28e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 5.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1449 DSPTGFDSSDITANSFTVHWVAPR---APITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGRE 1525
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 568905790 1526 ESPP 1529
Cdd:cd00063    82 ESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1541-1621 6.73e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 6.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1541 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1617
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                  ....
gi 568905790 1618 PASS 1621
Cdd:cd00063    84 PPSE 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1633-1720 7.64e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.06  E-value: 7.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 568905790 1710 ESQPLVQTAVT 1720
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1905-1984 9.06e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.60  E-value: 9.06e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1905 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1980
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  1981 RSSP 1984
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
698-1027 9.18e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 9.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  698 TTSASTPVTSNTVTGETAPYSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401   212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401   290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWT 927
Cdd:COG3401   370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  928 PPDSVVSGYRVEVLPVSLPgehgqrlPVNRNTFAEITGLSPGVTYLFKVFAVHQGRESNPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401   450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                         330       340
                  ....*....|....*....|
gi 568905790 1008 TDRTVLVTWTPPRARIAGYR 1027
Cdd:COG3401   523 APDGTPNVTGASPVTVGAST 542
fn1 pfam00039
Fibronectin type I domain;
561-599 1.10e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.95  E-value: 1.10e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790   561 CQDSETRTFYQIGDSWEKFVH-GVRYQCYCYGRGIGEWHC 599
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQrGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
2176-2215 1.61e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.57  E-value: 1.61e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790  2176 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRC 2215
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 1.92e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.22  E-value: 1.92e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
470-508 3.22e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.41  E-value: 3.22e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790   470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWAC 508
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
187-226 1.03e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 64.26  E-value: 1.03e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790   187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITC 226
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 810-888 1.62e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.62e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790    810 PDAPPDPTVDQVDDTSIVVRWSRPQ-----APITGYRIVYSPSvEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEE 884
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 568905790    885 NQES 888
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1358-1437 1.86e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.86e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1358 PPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568905790   1436 ES 1437
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 559-602 3.12e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 62.73  E-value: 3.12e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568905790  559 DQCQDSETRTFYQIGDSWEKFVHGVRYQCYCYGrGIGEWHCQPL 602
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
726-797 3.72e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 3.72e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568905790   726 SVTEITASSFVVSW---VSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGK 797
Cdd:pfam00041    7 TVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 5.20e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 62.37  E-value: 5.20e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790     98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2264-2303 7.73e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 7.73e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568905790 2264 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2303
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1994-2072 8.44e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 8.44e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1994 DAPSNLRFLTTTPNSLLVSWQAP-RARITGYIIKY--EKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2070
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYrvEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568905790   2071 KS 2072
Cdd:smart00060   82 EG 83
fn1 pfam00039
Fibronectin type I domain;
98-136 8.99e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 61.56  E-value: 8.99e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790    98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISC 136
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1358-1439 1.05e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1358 PPPTDLRFTNIGPDTMRVTWAPPPSI--ELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 568905790 1436 ESIP 1439
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
619-688 1.10e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 1.10e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568905790   619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 1.35e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.21  E-value: 1.35e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568905790    142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 96-137 1.66e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.81  E-value: 1.66e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568905790   96 ETCFDKYTGNTYKVGDTYERPKDSMIWDCTCIGaGRGRISCT 137
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1633-1711 1.74e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 1.74e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1633 DKPSQMQVTDVQDNSISVRWLP-----STSPVTGYRVTTTPKNGlgPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNR 1707
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPppddgITGYIVGYRVEYREEGS--EWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 568905790   1708 NGES 1711
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1541-1617 2.92e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 2.92e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1541 PRDLEVIASTPTSLLISWEPPAVS-----VRYYRITYGETGGNspVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1615
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568905790   1616 DS 1617
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1449-1527 3.37e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.09  E-value: 3.37e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1449 DSPTGFDSSDITANSFTVHWVAPRAP-ITGYIIRHHAEHSVGRPRQDRV--PPSRNSITLTNLNPGTEYVVSIIAVNGRE 1525
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568905790   1526 ES 1527
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 4.95e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 4.95e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 568905790   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2174-2218 6.08e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 6.08e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568905790 2174 DSCFDPYTVSHYAIGEEWERLSDaGFKLTCQCLGfGSGHFRCDSS 2218
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 907-994 6.29e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 6.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  907 PPPTDLQFVELTDVKVTIMWTPPD---SVVSGYRVEVLPVSLPGEHGQRLPVNRNTFAEITGLSPGVTYLFKVFAVHQGR 983
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 568905790  984 ESNPLTAQQTT 994
Cdd:cd00063    82 ESPPSESVTVT 92
fn1 pfam00039
Fibronectin type I domain;
2221-2258 6.41e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 58.86  E-value: 6.41e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790  2221 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKC 2258
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 185-228 1.41e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.11  E-value: 1.41e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568905790  185 EKCFDHAAGTSYVVGETWEKPYQGwMMVDCTCLGeGNGRITCTS 228
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2265-2305 2.01e-10

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 57.75  E-value: 2.01e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790   2265 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRCDNCRR 2305
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
524-555 3.80e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.94  E-value: 3.80e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568905790   524 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 555
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 468-511 4.47e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.57  E-value: 4.47e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568905790  468 EICTTNE-GVMYRIGDQWDKQHDlGHMMRCTCVGNgRGEWACIPY 511
Cdd:cd00061     1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
142-180 7.10e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.17  E-value: 7.10e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 568905790   142 CHE--GGQSYKIGDKWRRPHETGgYMLECLCLGNGKGEWTC 180
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1723-1803 1.14e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1723 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIRELFPAPDGEDDTAELQGLRPGSEYTVSVVALHDDM 1799
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 568905790 1800 ESQP 1803
Cdd:cd00063    82 ESPP 85
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 230-274 1.25e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.42  E-value: 1.25e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568905790  230 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCVCTGNgRGEWKCERH 274
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1813-1900 1.29e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1813 PAPTNLKFSQVTPTSFTAQWIAPS---VQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1889
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 568905790 1890 TSRPAQGVITT 1900
Cdd:cd00063    82 ESPPSESVTVT 92
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 53-93 1.76e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 55.05  E-value: 1.76e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790     53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNCESKPE 93
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1905-1985 1.78e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 1.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1905 SPPRRARVTDATETTITISW---RTKTETITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1980
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*
gi 568905790 1981 RSSPV 1985
Cdd:cd00063    82 ESPPS 86
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2220-2261 2.52e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 54.65  E-value: 2.52e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568905790 2220 WCHDN--GVNYKIGEKWDRQGEnGQRMSCTCLGNgKGEFKCDPH 2261
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
1723-1803 1.17e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.96  E-value: 1.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1723 DRPKGLAFTDVDVDSIKIAWESP---QGQVSRYRVTYSSPEDGIREL-FPAPDGEDdTAELQGLRPGSEYTVSVVALHDD 1798
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNeITVPGTTT-SVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 568905790  1799 MESQP 1803
Cdd:pfam00041   80 GEGPP 84
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 516-557 2.49e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 51.95  E-value: 2.49e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568905790  516 DQCIVDD--ITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDP 557
Cdd:cd00061     1 EKCFDPQtgVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
2265-2300 5.06e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 50.78  E-value: 5.06e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790  2265 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRC 2300
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1813-1884 5.37e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 5.37e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568905790   1813 PAPTNLKFSQVTPTSFTAQWIAPSV-QLTGYRV--RVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYA 1884
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 140-182 6.90e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 50.41  E-value: 6.90e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568905790  140 NRCHEG--GQSYKIGDKWRRPHEtgGYMLECLCLGNgKGEWTCKP 182
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 907-985 1.47e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 1.47e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790    907 PPPTDLQFVELTDVKVTIMWTPP-DSVVSGYRVEVLPVSLPGEHGQR--LPVNRNTFAEITGLSPGVTYLFKVFAVHQGR 983
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568905790    984 ES 985
Cdd:smart00060   82 EG 83
fn1 pfam00039
Fibronectin type I domain;
53-88 1.62e-07

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 49.23  E-value: 1.62e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790    53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNC 88
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1905-1979 2.40e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 2.40e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1905 SPPRRARVTDATETTITISWRTKTET-----ITGFQVDAIPANGQTpVQRSISPDVRSYTITGLQPGTDYKIHLYTLNDN 1979
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
fn3 pfam00041
Fibronectin type III domain;
2090-2145 8.02e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 8.02e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  2090 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEAL 2145
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 616-688 9.19e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 9.19e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568905790    616 ITETPSQPNSHPIQWNAPEPSHITKYILRWRP--KTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVeyREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1725-1801 1.41e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 1.41e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1725 PKGLAFTDVDVDSIKIAWESPQ-----GQVSRYRVTYSSPEDGIRELFPAPDgeDDTAELQGLRPGSEYTVSVVALHDDM 1799
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPS--STSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568905790   1800 ES 1801
Cdd:smart00060   82 EG 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 2.35e-05

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 43.49  E-value: 2.35e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    308 CVTD-SGVVYSVGMQWLKSQGNKQML-CTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 3.23e-05

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 43.09  E-value: 3.23e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568905790  307 HCVTDS-GVVYSVGMQWLKSQGNKQMLCTCLGN--GVSCQET 345
Cdd:cd00061     2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 611-678 8.65e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 8.65e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  611 PVQVIITETpsQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYE 678
Cdd:cd00063     4 PTNLRVTDV--TSTSVTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 4.24e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.60  E-value: 4.24e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 568905790    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 1.61e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 95.06  E-value: 1.61e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 568905790    413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 354-401 1.73e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 1.73e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 568905790  354 NSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 414-461 2.12e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 2.12e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 568905790  414 NSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
360-401 1.75e-20

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 86.08  E-value: 1.75e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568905790   360 CVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1541-1620 2.29e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.39  E-value: 2.29e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1541 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1617
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 568905790  1618 PAS 1620
Cdd:pfam00041   83 PPS 85
fn2 pfam00040
Fibronectin type II domain;
420-461 3.96e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 82.23  E-value: 3.96e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568905790   420 CHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1633-1713 4.83e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 80.92  E-value: 4.83e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  1710 ESQP 1713
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1470 7.48e-18

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 90.06  E-value: 7.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTAGLTRGGQPKQYNVGPLASKYPLRNLQPG--SEYTVTLVAVKG 1070
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSpaVGTATTATAVAG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1071 NQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGgeapreVTSDSGSIVVSGLTPGVEYTY 1150
Cdd:COG3401   134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT------VTSTTLVDGGGDIEPGTTYYY 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1151 TIQVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVvhaD 1227
Cdd:COG3401   208 RVAATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---T 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1228 QSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-------VPEVPQltDLSFVDITDSSIGLRWTPLNSSTIIGYRIT 1300
Cdd:COG3401   284 TTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdltPPAAPS--GLTATAVGSSSITLSWTASSDADVTGYNVY 361

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1301 VVAAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTAVPPPTDLRFTNiGPDTMRVTW 1377
Cdd:COG3401   362 RSTSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTA-SVDAVPLTD 437

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1378 APPPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGLDSPTGFDSS 1457
Cdd:COG3401   438 VAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517

                         490
                  ....*....|...
gi 568905790 1458 DITANSFTVHWVA 1470
Cdd:COG3401   518 AAVGGAPDGTPNV 530
fn3 pfam00041
Fibronectin type III domain;
1449-1529 3.80e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 78.23  E-value: 3.80e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1449 DSPTGFDSSDITANSFTVHWVAPR---APITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGRE 1525
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  1526 ESPP 1529
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1994-2074 1.06e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1994 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2070
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 568905790 2071 KSEP 2074
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 9.47e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 9.47e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568905790   811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1358-1439 1.93e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 1.93e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1358 PPPTDLRFTNIGPDTMRVTWAPPP--SIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  1436 ESIP 1439
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1994-2074 2.37e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.37e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1994 DAPSNLRFLTTTPNSLLVSWQAPRAR---ITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2070
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  2071 KSEP 2074
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 810-898 2.81e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.30  E-value: 2.81e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  810 PDAPPDPTVDQVDDTSIVVRWSRPQ---APITGYRIVYSPSVEGSSTELNLPE-TANSVTLSDLQPGVQYNITIYAVEEN 885
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 568905790  886 QESTPVFIQQETT 898
Cdd:cd00063    81 GESPPSESVTVTT 93
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 4.18e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.23  E-value: 4.18e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
232-271 1.05e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.65  E-value: 1.05e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 232-275 1.15e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.15e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568905790    232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERHA 275
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2221-2262 1.26e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.26e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568905790   2221 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2262
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1240-1758 1.41e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 79.66  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1240 LEYNVSVYTVKDDKESAPISDTVVPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSV 1319
Cdd:COG3401    22 AVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1320 GYYTVTGlePGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTWAPPPSIE-LTNLLVRYSPVKNE 1398
Cdd:COG3401   102 SVGGATN--TGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAgAGVVVSPDTSATAA 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1399 EDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGL----DSPTGFDSSDITANSFTVHWVAPRAP 1474
Cdd:COG3401   180 VATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPVTES 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1475 -ITGYII-RHHAEHS----VGRPRQdrvppsrNSITLTNLNPGTEYVVSIIAVNGR-EESPPLIGQQATVSDI----PRD 1543
Cdd:COG3401   260 dATGYRVyRSNSGDGpftkVATVTT-------TSYTDTGLTNGTTYYYRVTAVDAAgNESAPSNVVSVTTDLTppaaPSG 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1544 LEVIASTPTSLLISWEPPA-VSVRYYRItYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSK 1622
Cdd:COG3401   333 LTATAVGSSSITLSWTASSdADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSE 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1623 PVSINYKTEIDKPSQMQVTDVQDNSISVRWLPSTSPVTGYRVTTTP----------KNGLGPSKTKTASPDQTEMTIEGL 1692
Cdd:COG3401   412 EVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVladggdtgnaVPFTTTSSTVTATTTDTTTANLSV 491

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568905790 1693 QPTVEYVVSVYAQNRNGES-QPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSS 1758
Cdd:COG3401   492 TTGSLVGGSGASSVTNSVSvIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSAS 558
fn3 pfam00041
Fibronectin type III domain;
1813-1893 1.42e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1813 PAPTNLKFSQVTPTSFTAQWIAP---SVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1889
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  1890 TSRP 1893
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2176-2220 2.01e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 2.01e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790   2176 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRCDSSKW 2220
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1494-1947 2.45e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 78.89  E-value: 2.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1494 DRVPPSRNSITLTNLNPGTEYVVSIIAVNGREESPPLIGQQATVSDIPRDLEVIASTPTSLLISWEPPAVSVRYYRITYG 1573
Cdd:COG3401    95 TTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDT 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1574 ETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSKPVSINYKTEIDKPSQMQVTDVQDNSISVRWL 1653
Cdd:COG3401   175 SATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWD 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1654 PSTSP-VTGYRV--TTTPKNGLgpskTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNGESQPLVQTAVTNIDR-----P 1725
Cdd:COG3401   255 PVTESdATGYRVyrSNSGDGPF----TKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLtppaaP 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1726 KGLAFTDVDVDSIKIAWE-SPQGQVSRYRVTYSSPEDGI-RELFPAPDGE--DDTaelqGLRPGSEYTVSVVALHDD-ME 1800
Cdd:COG3401   331 SGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTyTKIAETVTTTsyTDT----GLTPGTTYYYKVTAVDAAgNE 406

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1801 SQPLIGIQSTAIPAPTNLKFSQVTPTSFTAQWIAPSVQLTGYRVRVNPKEKTGPMKEINLSP---DSSSVIVSGLMVATK 1877
Cdd:COG3401   407 SAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVpftTTSSTVTATTTDTTT 486

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1878 YEVSVYALKDTLTSRPAQGVITTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAIPANGQTPV 1947
Cdd:COG3401   487 ANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTS 556
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 2.97e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 2.97e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 3.72e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.72e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1449-1529 5.28e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 5.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1449 DSPTGFDSSDITANSFTVHWVAPR---APITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGRE 1525
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 568905790 1526 ESPP 1529
Cdd:cd00063    82 ESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1541-1621 6.73e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 6.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1541 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1617
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                  ....
gi 568905790 1618 PASS 1621
Cdd:cd00063    84 PPSE 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1633-1720 7.64e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.06  E-value: 7.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 568905790 1710 ESQPLVQTAVT 1720
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1905-1984 9.06e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.60  E-value: 9.06e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1905 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1980
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 568905790  1981 RSSP 1984
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
698-1027 9.18e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 9.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  698 TTSASTPVTSNTVTGETAPYSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401   212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401   290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWT 927
Cdd:COG3401   370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  928 PPDSVVSGYRVEVLPVSLPgehgqrlPVNRNTFAEITGLSPGVTYLFKVFAVHQGRESNPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401   450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                         330       340
                  ....*....|....*....|
gi 568905790 1008 TDRTVLVTWTPPRARIAGYR 1027
Cdd:COG3401   523 APDGTPNVTGASPVTVGAST 542
fn1 pfam00039
Fibronectin type I domain;
561-599 1.10e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.95  E-value: 1.10e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790   561 CQDSETRTFYQIGDSWEKFVH-GVRYQCYCYGRGIGEWHC 599
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQrGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
2176-2215 1.61e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.57  E-value: 1.61e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790  2176 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRC 2215
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 1.92e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.22  E-value: 1.92e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1267-1349 1.96e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.83  E-value: 1.96e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1267 PQLTDLSFVDITDSSIGLRWTPL--NSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGG 1344
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 568905790  1345 ESAPT 1349
Cdd:pfam00041   81 EGPPS 85
fn1 pfam00039
Fibronectin type I domain;
470-508 3.22e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.41  E-value: 3.22e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790   470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWAC 508
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
807-1297 5.28e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 74.65  E-value: 5.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  807 TTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQ 886
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  887 ESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWTPPDSVVSGYRVEVLPVSLPGEHGqrlpvnrntfaeitGL 966
Cdd:COG3401   134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGG--------------DI 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  967 SPGVTYLFKVFAVHQGRESNP----LTAQQTTKLDAPTNLQFVNETDRTVLVTWTP-PRARIAGYRLTAGLTRGGQPKQY 1041
Cdd:COG3401   200 EPGTTYYYRVAATDTGGESAPsnevSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKV 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1042 NVGPLASkYPLRNLQPGSEYTVTLVAVKGN-QQSPKATGVFTTLQPLRSIPPYN---TEVTETTIVITWTPAP---RIGF 1114
Cdd:COG3401   280 ATVTTTS-YTDTGLTNGTTYYYRVTAVDAAgNESAPSNVVSVTTDLTPPAAPSGltaTAVGSSSITLSWTASSdadVTGY 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1115 KLGVRPSQGGEAPREVTSDSG-SIVVSGLTPGVEYTYTIQVLRDGQERDAPIVNRVVTPLSPPTNLHLEA-------NPD 1186
Cdd:COG3401   359 NVYRSTSGGGTYTKIAETVTTtSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTAsvdavplTDV 438

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1187 TGVLTVSWERSTTPD---------ITGYRITTTPTNGQQGTSLEEVVHADQSSCTFENLNPGLEYNVSVYTVKDDKESAP 1257
Cdd:COG3401   439 AGATAAASAASNPGVsaavladggDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAA 518

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 568905790 1258 ISDTVVPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGY 1297
Cdd:COG3401   519 AVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSAS 558
fn1 pfam00039
Fibronectin type I domain;
187-226 1.03e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 64.26  E-value: 1.03e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790   187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITC 226
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 810-888 1.62e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.62e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790    810 PDAPPDPTVDQVDDTSIVVRWSRPQ-----APITGYRIVYSPSvEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEE 884
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 568905790    885 NQES 888
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
1174-1257 1.67e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.67e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1174 SPPTNLHL-EANPDTgvLTVSWERSTTP--DITGYRITTTPTNGQQGTsLEEVVHADQSSCTFENLNPGLEYNVSVYTVK 1250
Cdd:pfam00041    1 SAPSNLTVtDVTSTS--LTVSWTPPPDGngPITGYEVEYRPKNSGEPW-NEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 568905790  1251 DDKESAP 1257
Cdd:pfam00041   78 GGGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1358-1437 1.86e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.86e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1358 PPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568905790   1436 ES 1437
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1815-2065 2.33e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 72.34  E-value: 2.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1815 PTNLKFSQVTPTSFTAQWIAPSVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIvsGLMVATKYEVSVYALKDTLTSRPA 1894
Cdd:COG3401   144 GAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGG--DIEPGTTYYYRVAATDTGGESAPS 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1895 QGVITTLENVSP--PRRARVTDATETTITISWRTKTET-ITGFQvdaipangqtpVQRSISPDVR----------SYTIT 1961
Cdd:COG3401   222 NEVSVTTPTTPPsaPTGLTATADTPGSVTLSWDPVTESdATGYR-----------VYRSNSGDGPftkvatvtttSYTDT 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1962 GLQPGTDYKIHLYTLNDNARSSP--VIIDASTAI---DAPSNLRFLTTTPNSLLVSWQA-PRARITGYIIKYEKPGSPPR 2035
Cdd:COG3401   291 GLTNGTTYYYRVTAVDAAGNESApsNVVSVTTDLtppAAPSGLTATAVGSSSITLSWTAsSDADVTGYNVYRSTSGGGTY 370

                         250       260       270
                  ....*....|....*....|....*....|
gi 568905790 2036 EVVPRPRPGvTEATITGLEPGTEYTIYVIA 2065
Cdd:COG3401   371 TKIAETVTT-TSYTDTGLTPGTTYYYKVTA 399
fn3 pfam00041
Fibronectin type III domain;
997-1075 2.49e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 2.49e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   997 DAPTNLQFVNETDRTVLVTWTPPRAR---IAGYRLTAGLTRGGQPKQ-YNVGPLASKYPLRNLQPGSEYTVTLVAVKGNQ 1072
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 568905790  1073 QSP 1075
Cdd:pfam00041   81 EGP 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 559-602 3.12e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 62.73  E-value: 3.12e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568905790  559 DQCQDSETRTFYQIGDSWEKFVHGVRYQCYCYGrGIGEWHCQPL 602
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
726-797 3.72e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 3.72e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568905790   726 SVTEITASSFVVSW---VSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGK 797
Cdd:pfam00041    7 TVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 5.20e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 62.37  E-value: 5.20e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790     98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
907-987 7.29e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.20  E-value: 7.29e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   907 PPPTDLQFVELTDVKVTIMWTPP---DSVVSGYRVEVLPVSLpGEHGQRLPVNRNTF-AEITGLSPGVTYLFKVFAVHQG 982
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNS-GEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 568905790   983 RESNP 987
Cdd:pfam00041   80 GEGPP 84
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2264-2303 7.73e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 7.73e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568905790 2264 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2303
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1994-2072 8.44e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 8.44e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1994 DAPSNLRFLTTTPNSLLVSWQAP-RARITGYIIKY--EKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2070
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYrvEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568905790   2071 KS 2072
Cdd:smart00060   82 EG 83
fn1 pfam00039
Fibronectin type I domain;
98-136 8.99e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 61.56  E-value: 8.99e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790    98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISC 136
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1358-1439 1.05e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1358 PPPTDLRFTNIGPDTMRVTWAPPPSI--ELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 568905790 1436 ESIP 1439
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
619-688 1.10e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 1.10e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568905790   619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 1.35e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.21  E-value: 1.35e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568905790    142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 96-137 1.66e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.81  E-value: 1.66e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568905790   96 ETCFDKYTGNTYKVGDTYERPKDSMIWDCTCIGaGRGRISCT 137
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1633-1711 1.74e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 1.74e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1633 DKPSQMQVTDVQDNSISVRWLP-----STSPVTGYRVTTTPKNGlgPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNR 1707
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPppddgITGYIVGYRVEYREEGS--EWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 568905790   1708 NGES 1711
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 997-1083 2.88e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 2.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  997 DAPTNLQFVNETDRTVLVTWTPPR---ARIAGYRLTAGLTRGGQPKQYNVGPL-ASKYPLRNLQPGSEYTVTLVAVKGNQ 1072
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGsETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 568905790 1073 QSPKATGV-FTT 1083
Cdd:cd00063    82 ESPPSESVtVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1541-1617 2.92e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 2.92e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1541 PRDLEVIASTPTSLLISWEPPAVS-----VRYYRITYGETGGNspVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1615
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568905790   1616 DS 1617
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1449-1527 3.37e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.09  E-value: 3.37e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1449 DSPTGFDSSDITANSFTVHWVAPRAP-ITGYIIRHHAEHSVGRPRQDRV--PPSRNSITLTNLNPGTEYVVSIIAVNGRE 1525
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568905790   1526 ES 1527
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 4.95e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 4.95e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 568905790   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2174-2218 6.08e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 6.08e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568905790 2174 DSCFDPYTVSHYAIGEEWERLSDaGFKLTCQCLGfGSGHFRCDSS 2218
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 907-994 6.29e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 6.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  907 PPPTDLQFVELTDVKVTIMWTPPD---SVVSGYRVEVLPVSLPGEHGQRLPVNRNTFAEITGLSPGVTYLFKVFAVHQGR 983
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 568905790  984 ESNPLTAQQTT 994
Cdd:cd00063    82 ESPPSESVTVT 92
fn1 pfam00039
Fibronectin type I domain;
2221-2258 6.41e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 58.86  E-value: 6.41e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790  2221 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKC 2258
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 185-228 1.41e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.11  E-value: 1.41e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568905790  185 EKCFDHAAGTSYVVGETWEKPYQGwMMVDCTCLGeGNGRITCTS 228
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2265-2305 2.01e-10

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 57.75  E-value: 2.01e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790   2265 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRCDNCRR 2305
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1174-1263 2.79e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.05  E-value: 2.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1174 SPPTNLHLEANPDTGVlTVSWERSTTP--DITGYRITTTPTNGQQGTSLEeVVHADQSSCTFENLNPGLEYNVSVYTVKD 1251
Cdd:cd00063     2 SPPTNLRVTDVTSTSV-TLSWTPPEDDggPITGYVVEYREKGSGDWKEVE-VTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|..
gi 568905790 1252 DKESAPISDTVV 1263
Cdd:cd00063    80 GGESPPSESVTV 91
fn1 pfam00039
Fibronectin type I domain;
524-555 3.80e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.94  E-value: 3.80e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568905790   524 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 555
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 468-511 4.47e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.57  E-value: 4.47e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568905790  468 EICTTNE-GVMYRIGDQWDKQHDlGHMMRCTCVGNgRGEWACIPY 511
Cdd:cd00061     1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1264-1355 4.55e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 4.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1264 PEVPQltDLSFVDITDSSIGLRWTP--LNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLI 1341
Cdd:cd00063     1 PSPPT--NLRVTDVTSTSVTLSWTPpeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....
gi 568905790 1342 NGGESAPTTLTQQT 1355
Cdd:cd00063    79 GGGESPPSESVTVT 92
fn1 pfam00039
Fibronectin type I domain;
142-180 7.10e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.17  E-value: 7.10e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 568905790   142 CHE--GGQSYKIGDKWRRPHETGgYMLECLCLGNGKGEWTC 180
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1723-1803 1.14e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1723 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIRELFPAPDGEDDTAELQGLRPGSEYTVSVVALHDDM 1799
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 568905790 1800 ESQP 1803
Cdd:cd00063    82 ESPP 85
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 230-274 1.25e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.42  E-value: 1.25e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568905790  230 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCVCTGNgRGEWKCERH 274
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1813-1900 1.29e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1813 PAPTNLKFSQVTPTSFTAQWIAPS---VQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1889
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 568905790 1890 TSRPAQGVITT 1900
Cdd:cd00063    82 ESPPSESVTVT 92
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 53-93 1.76e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 55.05  E-value: 1.76e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790     53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNCESKPE 93
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1905-1985 1.78e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 1.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1905 SPPRRARVTDATETTITISW---RTKTETITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1980
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*
gi 568905790 1981 RSSPV 1985
Cdd:cd00063    82 ESPPS 86
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2220-2261 2.52e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 54.65  E-value: 2.52e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568905790 2220 WCHDN--GVNYKIGEKWDRQGEnGQRMSCTCLGNgKGEFKCDPH 2261
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
704-898 3.01e-09

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 62.66  E-value: 3.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  704 PVTSNTVTGETAPYSPVVATSESVTEITassfvVSWVSASDTVSgfrveYELSEEGDEPQYLDLPST-ATSVNIPDLLPG 782
Cdd:COG4733   528 PPQWPPVNVTTSESLSVVAQGTAVTTLT-----VSWDAPAGAVA-----YEVEWRRDDGNWVSVPRTsGTSFEVPGIYAG 597

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  783 RkYIVNVYQISEEGKQSLILSTSQTTA---PDAPPDPTVDQV--DDTSIVVRWSRPQ-APITGYRIVYSPSVEGSSTELN 856
Cdd:COG4733   598 D-YEVRVRAINALGVSSAWAASSETTVtgkTAPPPAPTGLTAtgGLGGITLSWSFPVdADTLRTEIRYSTTGDWASATVA 676

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 568905790  857 LPE-TANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETT 898
Cdd:COG4733   677 QALyPGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQAS 719
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 997-1074 3.84e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 3.84e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790    997 DAPTNLQFVNETDRTVLVTWTPP-----RARIAGYRLTaGLTRGGQPKQYNVGPLASKYPLRNLQPGSEYTVTLVAVKGN 1071
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVE-YREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 568905790   1072 QQS 1074
Cdd:smart00060   81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
1723-1803 1.17e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.96  E-value: 1.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  1723 DRPKGLAFTDVDVDSIKIAWESP---QGQVSRYRVTYSSPEDGIREL-FPAPDGEDdTAELQGLRPGSEYTVSVVALHDD 1798
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNeITVPGTTT-SVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 568905790  1799 MESQP 1803
Cdd:pfam00041   80 GEGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
563-940 1.32e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.40  E-value: 1.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  563 DSETRTFYQIGDSWEKFVHGVRYQCY--CYGRGIGEWHCQPLQTYPGTTGPVQVI-ITETPSQPNSHPIQWNAPEPSHIT 639
Cdd:COG3401   183 TSLTVTSTTLVDGGGDIEPGTTYYYRvaATDTGGESAPSNEVSVTTPTTPPSAPTgLTATADTPGSVTLSWDPVTESDAT 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  640 KYILrWRPKTSTGRWKE-ATIPGhlNSYTIKGLTPGVIYEgqlisiqqYGhreVTRFDFTTSASTPvtSNTVTGETAPYS 718
Cdd:COG3401   263 GYRV-YRSNSGDGPFTKvATVTT--TSYTDTGLTNGTTYY--------YR---VTAVDAAGNESAP--SNVVSVTTDLTP 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  719 PVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGK 797
Cdd:COG3401   327 PAAPSGLTATAVGSSSITLSWTASSDAdVTGYNVYRSTSGGG-TYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGN 405

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  798 QSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYR--IVYSPSVEGSSTELNLPETANSVTLSDLQPGVQY 875
Cdd:COG3401   406 ESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASnpGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTT 485

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568905790  876 NITIYAVEENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWTPPDSVVSGYRVEV 940
Cdd:COG3401   486 TANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDL 550
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1174-1255 2.16e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 2.16e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1174 SPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTSLEEV-VHADQSSCTFENLNPGLEYNVSVYTVKDD 1252
Cdd:smart00060    2 SPPSNLRVTDVTSTSV-TLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVnVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 568905790   1253 KES 1255
Cdd:smart00060   81 GEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 516-557 2.49e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 51.95  E-value: 2.49e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568905790  516 DQCIVDD--ITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDP 557
Cdd:cd00061     1 EKCFDPQtgVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
2265-2300 5.06e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 50.78  E-value: 5.06e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790  2265 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRC 2300
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1835-2144 5.32e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.09  E-value: 5.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1835 PSVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTLTSRPAQGVITTLENVSPPRRARVTD 1914
Cdd:COG3401    73 AGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDG 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1915 ATETTITISWRTKTETITGFQVDAIPANGQTpvQRSISPDVRSYTITGLQPGTDYKIHLYTLNDNARSSPV----IIDAS 1990
Cdd:COG3401   153 ANASGTTASSVAGAGVVVSPDTSATAAVATT--SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevsVTTPT 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1991 TAIDAPSNLRFLTTTPNSLLVSWQA-PRARITGYIIKYEKPGSPPREVVPRPRpgVTEATITGLEPGTEYTIYVIALKNN 2069
Cdd:COG3401   231 TPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKVATVT--TTSYTDTGLTNGTTYYYRVTAVDAA 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 2070 ----QKSEPLIGrkKTGQEAL-------------SQTTISWTPFQES--SEYIIscqpVGTDEEPLQFQV---PGTSTSA 2127
Cdd:COG3401   309 gnesAPSNVVSV--TTDLTPPaapsgltatavgsSSITLSWTASSDAdvTGYNV----YRSTSGGGTYTKiaeTVTTTSY 382

                         330
                  ....*....|....*..
gi 568905790 2128 TLTGLTRGVTYNIIVEA 2144
Cdd:COG3401   383 TDTGLTPGTTYYYKVTA 399
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1813-1884 5.37e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 5.37e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568905790   1813 PAPTNLKFSQVTPTSFTAQWIAPSV-QLTGYRV--RVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYA 1884
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 140-182 6.90e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 50.41  E-value: 6.90e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568905790  140 NRCHEG--GQSYKIGDKWRRPHEtgGYMLECLCLGNgKGEWTCKP 182
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 907-985 1.47e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 1.47e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790    907 PPPTDLQFVELTDVKVTIMWTPP-DSVVSGYRVEVLPVSLPGEHGQR--LPVNRNTFAEITGLSPGVTYLFKVFAVHQGR 983
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568905790    984 ES 985
Cdd:smart00060   82 EG 83
fn1 pfam00039
Fibronectin type I domain;
53-88 1.62e-07

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 49.23  E-value: 1.62e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568905790    53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNC 88
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1905-1979 2.40e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 2.40e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1905 SPPRRARVTDATETTITISWRTKTET-----ITGFQVDAIPANGQTpVQRSISPDVRSYTITGLQPGTDYKIHLYTLNDN 1979
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 726-808 6.02e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 6.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  726 SVTEITASSFVVSWVSASDT---VSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGKQSLIL 802
Cdd:cd00063     8 RVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                  ....*.
gi 568905790  803 STSQTT 808
Cdd:cd00063    88 SVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
1091-1158 7.06e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 7.06e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568905790  1091 PPYN---TEVTETTIVITWTPAPR-----IGFKLGVRPSQGGEAPREVT--SDSGSIVVSGLTPGVEYTYTIQVLRDG 1158
Cdd:pfam00041    2 APSNltvTDVTSTSLTVSWTPPPDgngpiTGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2090-2145 8.02e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 8.02e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  2090 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEAL 2145
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1270-1346 1.64e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 1.64e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568905790   1270 TDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGY--YTVTGLEPGIDYDISVITLINGGES 1346
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAVNGAGEG 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1875-2063 6.87e-06

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 51.48  E-value: 6.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1875 ATKYEVSVYALKDT--LTSRPAQGVITTLEnVSPPRRARVTDATETTITISWRTKTETITgFQVDAIPANGQ-TPVQRSI 1951
Cdd:COG4733   508 AVQHAPEKYAAIDAgaFDDVPPQWPPVNVT-TSESLSVVAQGTAVTTLTVSWDAPAGAVA-YEVEWRRDDGNwVSVPRTS 585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1952 SPdvrSYTITGLQPGtDYKIHLYTLNDNARSSPVIIDASTAI----DAPSNLRFLTTTPNSLLV--SW-QAPRARITGYI 2024
Cdd:COG4733   586 GT---SFEVPGIYAG-DYEVRVRAINALGVSSAWAASSETTVtgktAPPPAPTGLTATGGLGGItlSWsFPVDADTLRTE 661

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 568905790 2025 IKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYV 2063
Cdd:COG4733   662 IRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRA 700
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 726-790 7.49e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 7.49e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568905790    726 SVTEITASSFVVSW-VSASDTVSGFRVEYELSEEGDEPQYLDLPSTA--TSVNIPDLLPGRKYIVNVY 790
Cdd:smart00060    8 RVTDVTSTSVTLSWePPPDDGITGYIVGYRVEYREEGSEWKEVNVTPssTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 616-688 9.19e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 9.19e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568905790    616 ITETPSQPNSHPIQWNAPEPSHITKYILRWRP--KTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVeyREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1725-1801 1.41e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 1.41e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790   1725 PKGLAFTDVDVDSIKIAWESPQ-----GQVSRYRVTYSSPEDGIRELFPAPDgeDDTAELQGLRPGSEYTVSVVALHDDM 1799
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPS--STSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 568905790   1800 ES 1801
Cdd:smart00060   82 EG 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
723-1224 2.03e-05

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 49.94  E-value: 2.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  723 TSESVTEITASSFVVSWVSASDTVSGFRVEyelSEEGDE----PQYLDLPSTATSVNI-PDLLPGRKYIV--------NV 789
Cdd:COG4733   427 TLDRPVTMEAGDRYLRVRLPDGTSVARTVQ---SVAGRTltvsTAYSETPEAGAVWAFgPDELETQLFRVvsieenedGT 503

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  790 YQIS----EEGKQSLILSTSQTTAPDAPPDPTV----------DQVDDTSIVVRWSRPQAPITgYRIVYSPsveGSSTEL 855
Cdd:COG4733   504 YTITavqhAPEKYAAIDAGAFDDVPPQWPPVNVttseslsvvaQGTAVTTLTVSWDAPAGAVA-YEVEWRR---DDGNWV 579

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  856 NLPET-ANSVTLSDLQPGvQYNITIYAVEENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDvKVTIMWT-PPDSVV 933
Cdd:COG4733   580 SVPRTsGTSFEVPGIYAG-DYEVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTGLTATGGLG-GITLSWSfPVDADT 657

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  934 SGYRVEVLPVSLPGEHGQRLPVNRNTFAEITGLSPGVTYLFKVFAV-HQGRESnPLTAQQTTKLDAPTNLQFVN----ET 1008
Cdd:COG4733   658 LRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRARAVdRSGNVS-AWWVSGQASADAAGILDAITgqilET 736

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1009 DRTVLVTWTPPRARIAGYRLTAGLTRGGQpkqynVGPLASKYPLRNLQPGSEYTVTLVAVKGNQQSPKATGVFTTLQPLR 1088
Cdd:COG4733   737 ELGQELDAIIQNATVAEVVAATVTDVTAQ-----IDTAVLFAGVATAAAIGAEARVAATVAESATAAAATGTAADAAGDA 811

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1089 SIppYNTEVTETTIVITWTPAPRIgfklgvrpsqggeapREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQERDAPIVNR 1168
Cdd:COG4733   812 SG--GVTAGTSGTTGAGDTAASTT---------------RVAAAVVLAGVVVYGDAIIESGNTGDIVATGDIASAAAGAV 874

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568905790 1169 VVTplspPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVV 1224
Cdd:COG4733   875 ATT----VSGTTAADVSAVADSTAASLTAIVIAATTIIDAIGDGTTREPAGDIGAS 926
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 2.35e-05

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 43.49  E-value: 2.35e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568905790    308 CVTD-SGVVYSVGMQWLKSQGNKQML-CTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1095-1160 2.47e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 2.47e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568905790   1095 TEVTETTIVITWTP-------APRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQE 1160
Cdd:smart00060   10 TDVTSTSVTLSWEPppddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 3.23e-05

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 43.09  E-value: 3.23e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568905790  307 HCVTDS-GVVYSVGMQWLKSQGNKQMLCTCLGN--GVSCQET 345
Cdd:cd00061     2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 611-678 8.65e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 8.65e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790  611 PVQVIITETpsQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYE 678
Cdd:cd00063     4 PTNLRVTDV--TSTSVTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1095-1160 2.61e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 2.61e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568905790 1095 TEVTETTIVITWTP-----APRIGFKLGVRPSQGGEaPREVTSDSG---SIVVSGLTPGVEYTYTIQVLRDGQE 1160
Cdd:cd00063    10 TDVTSTSVTLSWTPpeddgGPITGYVVEYREKGSGD-WKEVEVTPGsetSYTLTGLKPGTEYEFRVRAVNGGGE 82
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1911-2138 4.18e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 42.62  E-value: 4.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1911 RVTDATETTITISWRTKTETITGFQVDAIP--------ANGQTPVQRSI----SPDVRS--YTITGLQPGTD--YKIHL- 1973
Cdd:COG4733   430 RPVTMEAGDRYLRVRLPDGTSVARTVQSVAgrtltvstAYSETPEAGAVwafgPDELETqlFRVVSIEENEDgtYTITAv 509

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1974 ------YTLNDNArsspvIIDASTAIDAPSNLRFLT--------TTPNSLLVSWQAPRARITgYIIKYEKPGSpprEVVP 2039
Cdd:COG4733   510 qhapekYAAIDAG-----AFDDVPPQWPPVNVTTSEslsvvaqgTAVTTLTVSWDAPAGAVA-YEVEWRRDDG---NWVS 580

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 2040 RPRPGVTEATITGLEPGTeYTIYVIAL-KNNQKSEPLIGRKK--TGQEA-------------LSQTTISWTPFQES--SE 2101
Cdd:COG4733   581 VPRTSGTSFEVPGIYAGD-YEVRVRAInALGVSSAWAASSETtvTGKTApppaptgltatggLGGITLSWSFPVDAdtLR 659

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 568905790 2102 YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTY 2138
Cdd:COG4733   660 TEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTY 696
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1097-1285 9.88e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 41.08  E-value: 9.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1097 VTETTIVITWTPAP-RIGFKLGVRPSqGGEAPREVTSDSGSIVVSGLTPGvEYTYTIQ-VLRDGQERDAPIVNRV----- 1169
Cdd:COG4733   549 TAVTTLTVSWDAPAgAVAYEVEWRRD-DGNWVSVPRTSGTSFEVPGIYAG-DYEVRVRaINALGVSSAWAASSETtvtgk 626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905790 1170 VTPLSPPTNLhlEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVVHAdQSSCTFENLNPGLEYNVSVYTV 1249
Cdd:COG4733   627 TAPPPAPTGL--TATGGLGGITLSWSFPVDADTLRTEIRYSTTGDWASATVAQALYP-GNTYTLAGLKAGQTYYYRARAV 703

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 568905790 1250 -KDDKESA-PISDTVVPEVPQLTDLSFVDITDSSIGLR 1285
Cdd:COG4733   704 dRSGNVSAwWVSGQASADAAGILDAITGQILETELGQE 741
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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