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Conserved domains on  [gi|564397101|ref|XP_006256198|]
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probable E3 ubiquitin-protein ligase HERC4 isoform X3 [Rattus norvegicus]

Protein Classification

E3 ubiquitin-protein ligase HERC family protein( domain architecture ID 18804227)

E3 ubiquitin-protein ligase HERC (HECT and RCC1 domain) family protein similar to human E3 ISG15--protein ligase HERC5, the major E3 ligase for ISG15 conjugation, that functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 639-985 1.50e-156

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


:

Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 465.50  E-value: 1.50e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 639 LILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDS-RLIWFSDK 717
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 718 TFEDSD---LFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNF 794
Cdd:cd00078   81 SFADEDhlkLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 795 TITVEN-FGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG 873
Cdd:cd00078  159 TIELDSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 874 NTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGESYLPV 951
Cdd:cd00078  239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPT 318

                        330       340       350
                 ....*....|....*....|....*....|....
gi 564397101 952 SHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFS 985
Cdd:cd00078  319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 7-273 2.23e-68

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 232.17  E-value: 2.23e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101   7 QVVALDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGlQGSEECIRVPRNIKSLSDiqIVQVACGYYHSLALSKAS 86
Cdd:COG5184   43 RVPGLS--NVVAVAAGGDHTCALKADGTVWCWGNNSYGQLG-DGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDG 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101  87 EVFCWGQNKYGQLGLGiECQKQTSPQLIKSLLGiPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLL 166
Cdd:COG5184  118 TVWCWGDNSSGQLGDG-TTTNRLTPVQVDAGLS-GVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQV 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 167 KSLRSqkIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTQIACGRQHTSAfVPSSGRI 246
Cdd:COG5184  196 GGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG--VVAIAAGGSHTCA-LKSDGTV 270

                        250       260
                 ....*....|....*....|....*..
gi 564397101 247 YSFGLGGNGQLGTGSTSNRKSPFTVKG 273
Cdd:COG5184  271 WCWGDNSYGQLGDGTTTDRSTPVKVPG 297
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 639-985 1.50e-156

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 465.50  E-value: 1.50e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 639 LILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDS-RLIWFSDK 717
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 718 TFEDSD---LFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNF 794
Cdd:cd00078   81 SFADEDhlkLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 795 TITVEN-FGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG 873
Cdd:cd00078  159 TIELDSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 874 NTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGESYLPV 951
Cdd:cd00078  239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPT 318

                        330       340       350
                 ....*....|....*....|....*....|....
gi 564397101 952 SHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFS 985
Cdd:cd00078  319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 665-984 8.53e-123

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 376.96  E-value: 8.53e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101   665 KKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSD----LFHLIGVICGLAIYNFT 740
Cdd:smart00119   4 KRVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANEehlsYFRFIGRVLGKALYDNR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101   741 IVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQL-LDYPEDDIEEtfcLNFTITVEN-FGATEVKELVLNGADTAV 818
Cdd:smart00119  84 LLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEELD---LTFSIVLTSeFGQVKVVELKPGGSNIPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101   819 NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPT 898
Cdd:smart00119 161 TEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQT 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101   899 IKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQ 976
Cdd:smart00119 241 IKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALspKFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREKLLL 320


                   ....*...
gi 564397101   977 AIDHNEGF 984
Cdd:smart00119 321 AINEGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 689-987 1.91e-114

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 354.22  E-value: 1.91e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101  689 LLIMRELLDPKYGMFRY-YEDSRLIWFSDKTFED-----SDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLD 762
Cdd:pfam00632   1 TLLSKELFDPNYGLFEYeTEDDRTYWFNPSSSESpdlelLDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101  763 DLKELMPDVGRSMQQLLDYpEDDIEETFCLNFTITVenFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASL 842
Cdd:pfam00632  81 DLESIDPELYKSLKSLLNM-DNDDDEDLGLTFTIPV--FGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101  843 FDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLT 922
Cdd:pfam00632 158 LEAFRKGFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVT 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564397101  923 GSDRIPILGMKSL-KLVIQSTGG-GESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI 987
Cdd:pfam00632 238 GSSRLPVGGFKSLpKFTIVRKGGdDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
590-987 2.19e-99

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 332.50  E-value: 2.19e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 590 TYPFVFDAQAKTTLLQTD-----AVLQMQMAIDQ---AHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKN 661
Cdd:COG5021  458 LYRFYFVEHRKKTLTKNDsrlgsFISLNKLDIRRikeDKRRKLFYSLKQKAKIFDPYLHIKVRRDRVFEDSYREIMDESG 537

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 662 IDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIW----FSDKTFEDSDLFHLIGVICGLAIY 737
Cdd:COG5021  538 DDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEYITEDLYTLpinpLSSINPEHLSYFKFLGRVIGKAIY 617

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 738 NFTIVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNFTITVENFGATEVKELVLNGADTA 817
Cdd:COG5021  618 DSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNNDID--ETILDLTFTVEDDSFGESRTVELIPNGRNIS 695

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 818 VNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG-NTNYDWKELEKNTEYKGeYWAEH 896
Cdd:COG5021  696 VTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGiPEDIDIDDWKSNTAYHG-YTEDS 774

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 897 PTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL-------KLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKET 969
Cdd:COG5021  775 PIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLqgsdgvrKFTIEKGGTDDDRLPSAHTCFNRLKLPEYSSKEK 854

                        410
                 ....*....|....*...
gi 564397101 970 LRCKLIQAIDHNEGFSLI 987
Cdd:COG5021  855 LRSKLLTAINEGAGFGLL 872
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 7-273 2.23e-68

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 232.17  E-value: 2.23e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101   7 QVVALDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGlQGSEECIRVPRNIKSLSDiqIVQVACGYYHSLALSKAS 86
Cdd:COG5184   43 RVPGLS--NVVAVAAGGDHTCALKADGTVWCWGNNSYGQLG-DGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDG 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101  87 EVFCWGQNKYGQLGLGiECQKQTSPQLIKSLLGiPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLL 166
Cdd:COG5184  118 TVWCWGDNSSGQLGDG-TTTNRLTPVQVDAGLS-GVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQV 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 167 KSLRSqkIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTQIACGRQHTSAfVPSSGRI 246
Cdd:COG5184  196 GGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG--VVAIAAGGSHTCA-LKSDGTV 270

                        250       260
                 ....*....|....*....|....*..
gi 564397101 247 YSFGLGGNGQLGTGSTSNRKSPFTVKG 273
Cdd:COG5184  271 WCWGDNSYGQLGDGTTTDRSTPVKVPG 297
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
138-187 3.17e-16

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 73.32  E-value: 3.17e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 564397101  138 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 187
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 639-985 1.50e-156

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 465.50  E-value: 1.50e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 639 LILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDS-RLIWFSDK 717
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 718 TFEDSD---LFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNF 794
Cdd:cd00078   81 SFADEDhlkLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 795 TITVEN-FGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG 873
Cdd:cd00078  159 TIELDSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 874 NTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGESYLPV 951
Cdd:cd00078  239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPT 318

                        330       340       350
                 ....*....|....*....|....*....|....
gi 564397101 952 SHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFS 985
Cdd:cd00078  319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 665-984 8.53e-123

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 376.96  E-value: 8.53e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101   665 KKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSD----LFHLIGVICGLAIYNFT 740
Cdd:smart00119   4 KRVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANEehlsYFRFIGRVLGKALYDNR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101   741 IVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQL-LDYPEDDIEEtfcLNFTITVEN-FGATEVKELVLNGADTAV 818
Cdd:smart00119  84 LLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEELD---LTFSIVLTSeFGQVKVVELKPGGSNIPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101   819 NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPT 898
Cdd:smart00119 161 TEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQT 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101   899 IKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQ 976
Cdd:smart00119 241 IKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALspKFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREKLLL 320


                   ....*...
gi 564397101   977 AIDHNEGF 984
Cdd:smart00119 321 AINEGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 689-987 1.91e-114

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 354.22  E-value: 1.91e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101  689 LLIMRELLDPKYGMFRY-YEDSRLIWFSDKTFED-----SDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLD 762
Cdd:pfam00632   1 TLLSKELFDPNYGLFEYeTEDDRTYWFNPSSSESpdlelLDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101  763 DLKELMPDVGRSMQQLLDYpEDDIEETFCLNFTITVenFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASL 842
Cdd:pfam00632  81 DLESIDPELYKSLKSLLNM-DNDDDEDLGLTFTIPV--FGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101  843 FDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLT 922
Cdd:pfam00632 158 LEAFRKGFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVT 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564397101  923 GSDRIPILGMKSL-KLVIQSTGG-GESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI 987
Cdd:pfam00632 238 GSSRLPVGGFKSLpKFTIVRKGGdDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
590-987 2.19e-99

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 332.50  E-value: 2.19e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 590 TYPFVFDAQAKTTLLQTD-----AVLQMQMAIDQ---AHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKN 661
Cdd:COG5021  458 LYRFYFVEHRKKTLTKNDsrlgsFISLNKLDIRRikeDKRRKLFYSLKQKAKIFDPYLHIKVRRDRVFEDSYREIMDESG 537

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 662 IDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIW----FSDKTFEDSDLFHLIGVICGLAIY 737
Cdd:COG5021  538 DDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEYITEDLYTLpinpLSSINPEHLSYFKFLGRVIGKAIY 617

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 738 NFTIVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNFTITVENFGATEVKELVLNGADTA 817
Cdd:COG5021  618 DSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNNDID--ETILDLTFTVEDDSFGESRTVELIPNGRNIS 695

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 818 VNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG-NTNYDWKELEKNTEYKGeYWAEH 896
Cdd:COG5021  696 VTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGiPEDIDIDDWKSNTAYHG-YTEDS 774

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 897 PTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL-------KLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKET 969
Cdd:COG5021  775 PIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLqgsdgvrKFTIEKGGTDDDRLPSAHTCFNRLKLPEYSSKEK 854

                        410
                 ....*....|....*...
gi 564397101 970 LRCKLIQAIDHNEGFSLI 987
Cdd:COG5021  855 LRSKLLTAINEGAGFGLL 872
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 7-273 2.23e-68

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 232.17  E-value: 2.23e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101   7 QVVALDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGlQGSEECIRVPRNIKSLSDiqIVQVACGYYHSLALSKAS 86
Cdd:COG5184   43 RVPGLS--NVVAVAAGGDHTCALKADGTVWCWGNNSYGQLG-DGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDG 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101  87 EVFCWGQNKYGQLGLGiECQKQTSPQLIKSLLGiPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLL 166
Cdd:COG5184  118 TVWCWGDNSSGQLGDG-TTTNRLTPVQVDAGLS-GVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQV 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 167 KSLRSqkIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTQIACGRQHTSAfVPSSGRI 246
Cdd:COG5184  196 GGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG--VVAIAAGGSHTCA-LKSDGTV 270

                        250       260
                 ....*....|....*....|....*..
gi 564397101 247 YSFGLGGNGQLGTGSTSNRKSPFTVKG 273
Cdd:COG5184  271 WCWGDNSYGQLGDGTTTDRSTPVKVPG 297
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 7-268 6.57e-66

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 225.24  E-value: 6.57e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101   7 QVVALDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLqGSEECIRVPRNI-KSLSDIqiVQVACGYYHSLALSKA 85
Cdd:COG5184   93 KVPGLT--GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTPVQVdAGLSGV--VAIAAGGYHTCALKSD 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101  86 SEVFCWGQNKYGQLGLGIECQkQTSPQLIKSLLGIpfMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 165
Cdd:COG5184  168 GTVWCWGANSYGQLGDGTTTD-RPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQ 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 166 LKSLRSqkIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTQIACGRQHTSAfVPSSGR 245
Cdd:COG5184  245 VAGLTG--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCA-LLTDGT 319

                        250       260
                 ....*....|....*....|...
gi 564397101 246 IYSFGLGGNGQLGTGSTSNRKSP 268
Cdd:COG5184  320 VWCWGDNAYGQLGDGTTTDRSTP 342
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 17-273 1.50e-65

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 224.09  E-value: 1.50e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101  17 VAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLqGSEECIRVPRNIKSLSDIqiVQVACGYYHSLALSKASEVFCWGQNKY 96
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGD-GTTTDRSTPVRVPGLSNV--VAVAAGGDHTCALKADGTVWCWGNNSY 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101  97 GQLGLGIEcQKQTSPQLIKSLLGipFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLkSLRSQKIVY 176
Cdd:COG5184   78 GQLGDGTT-TDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-DAGLSGVVA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 177 ICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTQIACGRQHTSAfVPSSGRIYSFGLGGNGQ 256
Cdd:COG5184  154 IAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCA-LKSDGTVWCWGSNSSGQ 230

                        250
                 ....*....|....*..
gi 564397101 257 LGTGSTSNRKSPFTVKG 273
Cdd:COG5184  231 LGDGTTTDRATPVQVAG 247
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 124-305 3.95e-33

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 131.25  E-value: 3.95e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 124 QVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRsqKIVYICCGEDHTAALTKEGGVFTFGAGGYGQ 203
Cdd:COG5184    2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLS--NVVAVAAGGDHTCALKADGTVWCWGNNSYGQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564397101 204 LGHNSTSHEINPRKVFELmgSIVTQIACGRQHTSAfVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVkgnwfsyngqcp 283
Cdd:COG5184   80 LGDGTTTDRTTPVKVPGL--TGVVAVAAGYYHSCA-LKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV------------ 144

                        170       180
                 ....*....|....*....|..
gi 564397101 284 qDIGSEDyfcVKRIFSGGDQSF 305
Cdd:COG5184  145 -DAGLSG---VVAIAAGGYHTC 162
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
138-187 3.17e-16

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 73.32  E-value: 3.17e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 564397101  138 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 187
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
32-82 1.68e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 71.39  E-value: 1.68e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 564397101   32 KGQVYAWGLDSDGQLGLqGSEECIRVPRNIKSLSDIQIVQVACGYYHSLAL 82
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGL-GTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
190-238 1.86e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 65.62  E-value: 1.86e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 564397101  190 EGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSA 238
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
87-135 4.01e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 64.46  E-value: 4.01e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 564397101   87 EVFCWGQNKYGQLGLGIEcQKQTSPQLIKSLLGIPFMQVAAGGAHSFVL 135
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTT-ENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
69-98 1.06e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 54.35  E-value: 1.06e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 564397101   69 IVQVACGYYHSLALSKASEVFCWGQNKYGQ 98
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
16-45 2.59e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 50.50  E-value: 2.59e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 564397101   16 IVAVSCGEAHTLALNDKGQVYAWGLDSDGQ 45
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
124-151 1.30e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 45.49  E-value: 1.30e-06
                          10        20
                  ....*....|....*....|....*...
gi 564397101  124 QVAAGGAHSFVLTLSGAIFGWGRNKFGQ 151
Cdd:pfam13540   3 SVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
243-273 1.09e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 43.27  E-value: 1.09e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 564397101  243 SGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 273
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG 31
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
174-203 1.19e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.80  E-value: 1.19e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 564397101  174 IVYICCGEDHTAALTKEGGVFTFGAGGYGQ 203
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
226-256 5.10e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 38.17  E-value: 5.10e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 564397101  226 VTQIACGRQHTsAFVPSSGRIYSFGLGGNGQ 256
Cdd:pfam13540   1 VVSVAAGDNHT-LALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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