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Conserved domains on  [gi|564396974|ref|XP_006256138|]
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G patch domain and ankyrin repeat-containing protein 1 isoform X2 [Rattus norvegicus]

Protein Classification

ankyrin repeat domain-containing protein; ankyrin repeat and MYND domain-containing protein( domain architecture ID 12122224)

ankyrin repeat (ANK) domain-containing protein mediates specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions| ankyrin repeat and MYND domain-containing protein similar to ANKMY2 that may be involved in the trafficking of signaling proteins to the cilia

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 253-297 2.79e-13

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


:

Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 63.30  E-value: 2.79e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564396974  253 TSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYR 297
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
104-194 9.33e-12

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.98  E-value: 9.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564396974 104 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 183
Cdd:COG0666  157 LHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAEN 229

                         90
                 ....*....|.
gi 564396974 184 GFPEVARMVRE 194
Cdd:COG0666  230 GNLEIVKLLLE 240
 
Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 253-297 2.79e-13

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 63.30  E-value: 2.79e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564396974  253 TSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYR 297
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 251-296 3.34e-12

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 60.64  E-value: 3.34e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 564396974   251 VPTSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGY 296
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
104-194 9.33e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.98  E-value: 9.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564396974 104 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 183
Cdd:COG0666  157 LHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAEN 229

                         90
                 ....*....|.
gi 564396974 184 GFPEVARMVRE 194
Cdd:COG0666  230 GNLEIVKLLLE 240
Ank_2 pfam12796
Ankyrin repeats (3 copies);
104-191 2.33e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 2.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564396974  104 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWvgvCELGGRDAAQLAEEA 183
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE------NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARS 71


                  ....*...
gi 564396974  184 GFPEVARM 191
Cdd:pfam12796  72 GHLEIVKL 79
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 108-244 2.65e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 2.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564396974 108 AQNGDLTELRRLLEpqeaGGAggNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEAGFPE 187
Cdd:PTZ00322  90 AASGDAVGARILLT----GGA--DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGAD-PTLLDKDGKTPLELAEENGFRE 162

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564396974 188 VARMVreSRGETRSPENQNRSPPSSSQFCEdcgAYFEDSnhrTSTAHLLSLSRRPQP 244
Cdd:PTZ00322 163 VVQLL--SRHSQCHFELGANAKPDSFTGKP---PSLEDS---PISSHHPDFSAVPQP 211
 
Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 253-297 2.79e-13

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 63.30  E-value: 2.79e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564396974  253 TSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYR 297
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 251-296 3.34e-12

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 60.64  E-value: 3.34e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 564396974   251 VPTSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGY 296
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
104-194 9.33e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.98  E-value: 9.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564396974 104 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 183
Cdd:COG0666  157 LHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAEN 229

                         90
                 ....*....|.
gi 564396974 184 GFPEVARMVRE 194
Cdd:COG0666  230 GNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
104-191 5.02e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.66  E-value: 5.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564396974 104 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 183
Cdd:COG0666   91 LHAAARNGDLEIVKLLLE------AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD-VNAQDNDGNTPLHLAAAN 163


                 ....*...
gi 564396974 184 GFPEVARM 191
Cdd:COG0666  164 GNLEIVKL 171
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
104-191 1.31e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.51  E-value: 1.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564396974 104 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 183
Cdd:COG0666  124 LHLAAYNGNLEIVKLLLE------AGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD-VNARDNDGETPLHLAAEN 196


                 ....*...
gi 564396974 184 GFPEVARM 191
Cdd:COG0666  197 GHLEIVKL 204
Ank_2 pfam12796
Ankyrin repeats (3 copies);
104-191 2.33e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 2.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564396974  104 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWvgvCELGGRDAAQLAEEA 183
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE------NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARS 71


                  ....*...
gi 564396974  184 GFPEVARM 191
Cdd:pfam12796  72 GHLEIVKL 79
Ank_4 pfam13637
Ankyrin repeats (many copies);
104-159 2.78e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.88  E-value: 2.78e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 564396974  104 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLL 159
Cdd:pfam13637   5 LHAAAASGHLELLRLLLE------KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
106-191 2.31e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 48.41  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564396974 106 MAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWVGVCELGGRDAAQLAEEAGF 185
Cdd:COG0666  192 LAAENGHLEIVKLLLE------AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAA 265


                 ....*.
gi 564396974 186 PEVARM 191
Cdd:COG0666  266 LIVKLL 271
Ank_2 pfam12796
Ankyrin repeats (3 copies);
104-163 1.12e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.57  E-value: 1.12e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564396974  104 ILM-AAQNGDLTELRRLLEpqeaggaGGNINARDAFWwTPLMCAARAGQGAAVRYLLGRGA 163
Cdd:pfam12796  33 ALHlAAKNGHLEIVKLLLE-------HADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGA 85
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
105-191 7.11e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.17  E-value: 7.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564396974 105 LMAAQNGDLTELRRLLEpqeagGAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEAG 184
Cdd:COG0666   58 LLAAALAGDLLVALLLL-----AAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLHLAAYNG 131


                 ....*..
gi 564396974 185 FPEVARM 191
Cdd:COG0666  132 NLEIVKL 138
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 108-244 2.65e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 2.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564396974 108 AQNGDLTELRRLLEpqeaGGAggNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEAGFPE 187
Cdd:PTZ00322  90 AASGDAVGARILLT----GGA--DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGAD-PTLLDKDGKTPLELAEENGFRE 162

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564396974 188 VARMVreSRGETRSPENQNRSPPSSSQFCEdcgAYFEDSnhrTSTAHLLSLSRRPQP 244
Cdd:PTZ00322 163 VVQLL--SRHSQCHFELGANAKPDSFTGKP---PSLEDS---PISSHHPDFSAVPQP 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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