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Conserved domains on  [gi|564395488|ref|XP_006255536|]
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rho family-interacting cell polarization regulator 1 isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PL48 pfam15903
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific ...
31-379 0e+00

Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.


:

Pssm-ID: 464930  Cd Length: 297  Bit Score: 553.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488    31 VSRSQSFAGVLGSQERgpRNFTVFSPPGPQRKPLvlSRVSRMFSVAH---PAPKVPQPERLDLVYAALKRGLTAYLEVHQ 107
Cdd:pfam15903    1 ITRSQSFAGFSSAQER--RNLSSFSRPSLRSKPP--SKSSRMFTSSHksgPPPKVPQPERVDRVYEALKKGLKEYLEVHQ 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   108 QEQEKLQRQIKESKRNSRLGFLYDLDKQVKSIERFLRRLEFHASKidelyeaycvqrrlrdgaynmvraystgspgsrea 187
Cdd:pfam15903   77 AELDKLSRQQKDTKRNSRLGFLYDLDKQIKSVERYIRRLEFHISK----------------------------------- 121
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   188 rdslaeatrghreyteSMCLLENELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIESSGKQVWDSEE 267
Cdd:pfam15903  122 ----------------DMCLLEGELENLLGEFHIKMKGLAGFARLCPGDQYEVLMRYGRQRWKLRGRIETDDKQVWDEEE 185
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   268 TVFLPLLTEFLSIKVTELKGLANHVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVIWSPFDKDDQPSAASTVNK 347
Cdd:pfam15903  186 MVFLPLIHENFEIKVTELKGLANHVLVGSVTCETKDLFAARPQVVAVDINDLGTIKLQLEVTWNPFDKEDQLPSASSVSK 265
                          330       340       350
                   ....*....|....*....|....*....|..
gi 564395488   348 ASTVTKRFSTYSQSPPDTPSLREQAFYNMLRR 379
Cdd:pfam15903  266 ASVVSRRGSVYSWTPPDTPSFREKYFLSMLRQ 297
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
511-761 7.12e-10

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 63.40  E-value: 7.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   511 ADNGRSATSPALSTAGPAPTFIDPAsstqLDLVHKATDSGSSELPSITH-----TMASSTYSAVSPIN-SVPGLTSTTVG 584
Cdd:pfam05109  409 ATNATTTTHKVIFSKAPESTTTSPT----LNTTGFAAPNTTTGLPSSTHvptnlTAPASTGPTVSTADvTSPTPAGTTSG 484
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   585 STH-KPMPSPLT--STGSIPSVTDSIQTTTSPTHTTPSPTHTTVSPTHSTPSPTHTTVSPSNAALSPSNATPSLSHSTTS 661
Cdd:pfam05109  485 ASPvTPSPSPRDngTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTT 564
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   662 PTQKATMsthttsavgPVQTTTSPISTTVSPSPSVDTAIISSSSavpsvpgPEARPCSH----PTSTPYTKADP---TAA 734
Cdd:pfam05109  565 PTPNATI---------PTLGKTSPTSAVTTPTPNATSPTVGETS-------PQANTTNHtlggTSSTPVVTSPPknaTSA 628
                          250       260
                   ....*....|....*....|....*..
gi 564395488   735 CTSSPSLASSGPKPLTSPAPDSLEQIL 761
Cdd:pfam05109  629 VTTGQHNITSSSTSSMSLRPSSISETL 655
HEAT COG1413
HEAT repeat [General function prediction only];
1077-1198 1.41e-07

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 51.94  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488 1077 LLVQNLNSDDQAVVLKALRLApeGRLR-KDGLRALSSLLVHGNSKVMAAVStqlrsLSLGPVFRERALLCFLDQLEDEDV 1155
Cdd:COG1413    20 ALIAALADEDPDVRAAAARAL--GRLGdPRAVPALLEALKDPDPEVRAAAA-----EALGRIGDPEAVPALIAALKDEDP 92
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 564395488 1156 QTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQ 1198
Cdd:COG1413    93 EVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARALGR 135
HR1 super family cl00087
Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small ...
152-219 5.59e-04

Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases; The HR1 domain, also called the ACC (anti-parallel coiled-coil) finger domain or Rho-binding domain binds small GTPases from the Rho family. It is found in Rho effector proteins including PKC-related kinases such as vertebrate PRK1 (or PKN) and yeast PKC1 protein kinases C, as well as in rhophilins and Rho-associated kinase (ROCK). Rho family members function as molecular switches, cycling between inactive and active forms, controlling a variety of cellular processes. HR1 domains may occur in repeat arrangements (PKN contains three HR1 domains), separated by a short linker region.


The actual alignment was detected with superfamily member cd11636:

Pssm-ID: 469609  Cd Length: 74  Bit Score: 39.57  E-value: 5.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564395488  152 KIDELYEAYCVQRRLRDGAYNMVRAYSTGSPGSREArdsLAEATRGHREYTESMCLLENELEAQLGEF 219
Cdd:cd11636    10 RIEELRHHFRVEHAVAEGAKNVLRLLGAGKAQDRKA---ISEAQSKLSESSQKLDLLRVSLEQRLVEL 74
 
Name Accession Description Interval E-value
PL48 pfam15903
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific ...
31-379 0e+00

Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.


Pssm-ID: 464930  Cd Length: 297  Bit Score: 553.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488    31 VSRSQSFAGVLGSQERgpRNFTVFSPPGPQRKPLvlSRVSRMFSVAH---PAPKVPQPERLDLVYAALKRGLTAYLEVHQ 107
Cdd:pfam15903    1 ITRSQSFAGFSSAQER--RNLSSFSRPSLRSKPP--SKSSRMFTSSHksgPPPKVPQPERVDRVYEALKKGLKEYLEVHQ 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   108 QEQEKLQRQIKESKRNSRLGFLYDLDKQVKSIERFLRRLEFHASKidelyeaycvqrrlrdgaynmvraystgspgsrea 187
Cdd:pfam15903   77 AELDKLSRQQKDTKRNSRLGFLYDLDKQIKSVERYIRRLEFHISK----------------------------------- 121
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   188 rdslaeatrghreyteSMCLLENELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIESSGKQVWDSEE 267
Cdd:pfam15903  122 ----------------DMCLLEGELENLLGEFHIKMKGLAGFARLCPGDQYEVLMRYGRQRWKLRGRIETDDKQVWDEEE 185
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   268 TVFLPLLTEFLSIKVTELKGLANHVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVIWSPFDKDDQPSAASTVNK 347
Cdd:pfam15903  186 MVFLPLIHENFEIKVTELKGLANHVLVGSVTCETKDLFAARPQVVAVDINDLGTIKLQLEVTWNPFDKEDQLPSASSVSK 265
                          330       340       350
                   ....*....|....*....|....*....|..
gi 564395488   348 ASTVTKRFSTYSQSPPDTPSLREQAFYNMLRR 379
Cdd:pfam15903  266 ASVVSRRGSVYSWTPPDTPSFREKYFLSMLRQ 297
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
511-761 7.12e-10

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 63.40  E-value: 7.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   511 ADNGRSATSPALSTAGPAPTFIDPAsstqLDLVHKATDSGSSELPSITH-----TMASSTYSAVSPIN-SVPGLTSTTVG 584
Cdd:pfam05109  409 ATNATTTTHKVIFSKAPESTTTSPT----LNTTGFAAPNTTTGLPSSTHvptnlTAPASTGPTVSTADvTSPTPAGTTSG 484
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   585 STH-KPMPSPLT--STGSIPSVTDSIQTTTSPTHTTPSPTHTTVSPTHSTPSPTHTTVSPSNAALSPSNATPSLSHSTTS 661
Cdd:pfam05109  485 ASPvTPSPSPRDngTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTT 564
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   662 PTQKATMsthttsavgPVQTTTSPISTTVSPSPSVDTAIISSSSavpsvpgPEARPCSH----PTSTPYTKADP---TAA 734
Cdd:pfam05109  565 PTPNATI---------PTLGKTSPTSAVTTPTPNATSPTVGETS-------PQANTTNHtlggTSSTPVVTSPPknaTSA 628
                          250       260
                   ....*....|....*....|....*..
gi 564395488   735 CTSSPSLASSGPKPLTSPAPDSLEQIL 761
Cdd:pfam05109  629 VTTGQHNITSSSTSSMSLRPSSISETL 655
HEAT COG1413
HEAT repeat [General function prediction only];
1077-1198 1.41e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 51.94  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488 1077 LLVQNLNSDDQAVVLKALRLApeGRLR-KDGLRALSSLLVHGNSKVMAAVStqlrsLSLGPVFRERALLCFLDQLEDEDV 1155
Cdd:COG1413    20 ALIAALADEDPDVRAAAARAL--GRLGdPRAVPALLEALKDPDPEVRAAAA-----EALGRIGDPEAVPALIAALKDEDP 92
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 564395488 1156 QTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQ 1198
Cdd:COG1413    93 EVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARALGR 135
PHA03247 PHA03247
large tegument protein UL36; Provisional
412-802 1.47e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 1.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  412 STPKPLVQQPEPLPVQVTFRRPESLSSGSMDEEPPLTPALVNGHAPYSRTLSHISEASVDAALTEAMEAVDLKCPAPGPS 491
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR 2684
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  492 PLVYPesthvehvSSVPPVADNGRSATSPalSTAGPAPTFIDPAssTQLDLVHKATDSGSSELPSITHTMASSTYSAVSP 571
Cdd:PHA03247 2685 RRAAR--------PTVGSLTSLADPPPPP--PTPEPAPHALVSA--TPLPPGPAAARQASPALPAAPAPPAVPAGPATPG 2752
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  572 INSVPGLTSTTVGSthkPMPSPLTSTGSIPsvtdsiQTTTSPTHTTPSPTHTTVSPTHSTPSPTHTTVSPSNAALSPSNA 651
Cdd:PHA03247 2753 GPARPARPPTTAGP---PAPAPPAAPAAGP------PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  652 TPSLSHSTTSPTQKATmsthtTSAVGPVQTTTsPISTTVSPSpsvdtaiissssavpsvpGPEAR--PCSHPTSTPYTKA 729
Cdd:PHA03247 2824 PAGPLPPPTSAQPTAP-----PPPPGPPPPSL-PLGGSVAPG------------------GDVRRrpPSRSPAAKPAAPA 2879
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  730 DPTAACTSSPSLASS---------GPKPLTSP--APDSLEQILKSPSSSPSSIVPEPQRSELSLALVAQ-APVPEATGGA 797
Cdd:PHA03247 2880 RPPVRRLARPAVSRStesfalppdQPERPPQPqaPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDpAGAGEPSGAV 2959

                  ....*
gi 564395488  798 GDRRL 802
Cdd:PHA03247 2960 PQPWL 2964
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
562-754 1.69e-06

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 52.06  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  562 ASSTYSAVSPINSVPGLTSTTVGSTHKPMPSPLTSTGSIPSV--TDSIQTTTSPTHTTPSPTHTTVSPTHSTPSPTHTTV 639
Cdd:COG3469     1 SSSVSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVvsTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  640 SPSNAALSPSNATPSLSHSTTSPTQKATMSTHTTSAVGPVQTTTSPISTTVSPSPS------VDTAIISSSSAVPSVPGP 713
Cdd:COG3469    81 TATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSgasatsSAGSTTTTTTVSGTETAT 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 564395488  714 EARPCSHPTSTPYTKADPTAACTSSPSLASSGPKPLTSPAP 754
Cdd:COG3469   161 GGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTT 201
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
1107-1197 2.33e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 41.17  E-value: 2.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  1107 LRALSSLLVHGNSKVMAAVSTQlrslSLGPVFRERALLCFLDQLEDEDVQTRVAGCLALGCIKAPEGIEPLVYLCQTDTE 1186
Cdd:pfam13646    1 LPALLQALLRDPDPEVRAAAIR----ALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLRDDDD 76
                           90
                   ....*....|..
gi 564395488  1187 A-VREAARQSLQ 1197
Cdd:pfam13646   77 DvVRAAAAEALA 88
HR1_PKN1_3 cd11636
Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein ...
152-219 5.59e-04

Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1; PKN1, also called PKNalpha or Protein-kinase C-related kinase 1 (PRK1), is a serine/threonine protein kinase that is activated by the Rho family of small GTPases, and by fatty acids such as arachidonic and linoleic acids. It is expressed ubiquitously and is the most abundant PKN isoform in neurons. PKN1 is implicated in a variety of functions including cytoskeletal reorganization, cardiac cell survival, cell adhesion, and glucose transport, among others. PKN1 contains three HR1 domains, a C2 domain, and a kinase domain. This model characterizes the third HR1 domain of PKN1. HR1 domains are anti-parallel coiled-coil (ACC) domains that bind small GTPases from the Rho family; PKN1 binds the GTPases RhoA, RhoB, and RhoC, and can also interact weakly with Rac.


Pssm-ID: 212026  Cd Length: 74  Bit Score: 39.57  E-value: 5.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564395488  152 KIDELYEAYCVQRRLRDGAYNMVRAYSTGSPGSREArdsLAEATRGHREYTESMCLLENELEAQLGEF 219
Cdd:cd11636    10 RIEELRHHFRVEHAVAEGAKNVLRLLGAGKAQDRKA---ISEAQSKLSESSQKLDLLRVSLEQRLVEL 74
 
Name Accession Description Interval E-value
PL48 pfam15903
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific ...
31-379 0e+00

Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.


Pssm-ID: 464930  Cd Length: 297  Bit Score: 553.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488    31 VSRSQSFAGVLGSQERgpRNFTVFSPPGPQRKPLvlSRVSRMFSVAH---PAPKVPQPERLDLVYAALKRGLTAYLEVHQ 107
Cdd:pfam15903    1 ITRSQSFAGFSSAQER--RNLSSFSRPSLRSKPP--SKSSRMFTSSHksgPPPKVPQPERVDRVYEALKKGLKEYLEVHQ 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   108 QEQEKLQRQIKESKRNSRLGFLYDLDKQVKSIERFLRRLEFHASKidelyeaycvqrrlrdgaynmvraystgspgsrea 187
Cdd:pfam15903   77 AELDKLSRQQKDTKRNSRLGFLYDLDKQIKSVERYIRRLEFHISK----------------------------------- 121
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   188 rdslaeatrghreyteSMCLLENELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIESSGKQVWDSEE 267
Cdd:pfam15903  122 ----------------DMCLLEGELENLLGEFHIKMKGLAGFARLCPGDQYEVLMRYGRQRWKLRGRIETDDKQVWDEEE 185
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   268 TVFLPLLTEFLSIKVTELKGLANHVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVIWSPFDKDDQPSAASTVNK 347
Cdd:pfam15903  186 MVFLPLIHENFEIKVTELKGLANHVLVGSVTCETKDLFAARPQVVAVDINDLGTIKLQLEVTWNPFDKEDQLPSASSVSK 265
                          330       340       350
                   ....*....|....*....|....*....|..
gi 564395488   348 ASTVTKRFSTYSQSPPDTPSLREQAFYNMLRR 379
Cdd:pfam15903  266 ASVVSRRGSVYSWTPPDTPSFREKYFLSMLRQ 297
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
511-761 7.12e-10

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 63.40  E-value: 7.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   511 ADNGRSATSPALSTAGPAPTFIDPAsstqLDLVHKATDSGSSELPSITH-----TMASSTYSAVSPIN-SVPGLTSTTVG 584
Cdd:pfam05109  409 ATNATTTTHKVIFSKAPESTTTSPT----LNTTGFAAPNTTTGLPSSTHvptnlTAPASTGPTVSTADvTSPTPAGTTSG 484
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   585 STH-KPMPSPLT--STGSIPSVTDSIQTTTSPTHTTPSPTHTTVSPTHSTPSPTHTTVSPSNAALSPSNATPSLSHSTTS 661
Cdd:pfam05109  485 ASPvTPSPSPRDngTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTT 564
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   662 PTQKATMsthttsavgPVQTTTSPISTTVSPSPSVDTAIISSSSavpsvpgPEARPCSH----PTSTPYTKADP---TAA 734
Cdd:pfam05109  565 PTPNATI---------PTLGKTSPTSAVTTPTPNATSPTVGETS-------PQANTTNHtlggTSSTPVVTSPPknaTSA 628
                          250       260
                   ....*....|....*....|....*..
gi 564395488   735 CTSSPSLASSGPKPLTSPAPDSLEQIL 761
Cdd:pfam05109  629 VTTGQHNITSSSTSSMSLRPSSISETL 655
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
490-794 2.80e-09

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 61.13  E-value: 2.80e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   490 PSPLVYPESTHVEHVSSVPPVADN---GRSATSPALSTA---GPAPTFIDPASSTQLDLVHKATDSGSSELPSITH---- 559
Cdd:pfam17823   67 PAPVTLTKGTSAAHLNSTEVTAEHtphGTDLSEPATREGaadGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFsapr 146
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   560 TMASSTYSAVSPINSVPGLTSTTVGSthkPMPSPLTSTGSIPSVTDSIQTTTSPTHTTPSPTHTTVSPTHS----TPSPT 635
Cdd:pfam17823  147 AAACRANASAAPRAAIAAASAPHAAS---PAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTaataTGHPA 223
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   636 HTTVSPSNAALSPSNATPSLSHSTTSPTQKATMSTH--TTSAVGPVQTTTSPISTTVSPSPSVDTAIISSSSAvpsvpgp 713
Cdd:pfam17823  224 AGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAagTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPA------- 296
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   714 earpcshPTSTPYTKAdPTAACTSSPSLASSGPKPLTSPAPDSLEQILKSPSSSPSSIV--------PEPQRSELSLALV 785
Cdd:pfam17823  297 -------APMGAQAQG-PIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVvtttkaqaKEPSASPVPVLHT 368

                   ....*....
gi 564395488   786 AQAPVPEAT 794
Cdd:pfam17823  369 SMIPEVEAT 377
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
407-745 6.23e-08

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 56.89  E-value: 6.23e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   407 TARYSSTPKPLVQQpeplpVQVTFRRPESLSSGSMDEEPPLTPALVNGHAPYSRTLShiSEASVDAALTEAMEAVDLKCP 486
Cdd:pfam17823  116 AAAASSSPSSAAQS-----LPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASA--PHAASPAPRTAASSTTAASST 188
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   487 APGPSPLVYPESTHVEHVSSVPPVADNGRSATSPALSTAGPAPTFIDPASSTQLDLVHKATDSGSSELPSITHTMASS-- 564
Cdd:pfam17823  189 TAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAag 268
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   565 TYSAVSPINSVPgltsttvgSTHKPMPSPLTSTGSIPSVTDSIQTTTSPTHTTpspthttvSPTHST-PSPTHttvSPSN 643
Cdd:pfam17823  269 TINMGDPHARRL--------SPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTD--------QPVHNTaGEPTP---SPSN 329
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   644 AALSPSNATPSLSHSTTSPTQKATMSTHTTSAVGPVQTT--------TSPiSTTVSPSPSVDTAIISSSSAVPSVPGPEA 715
Cdd:pfam17823  330 TTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTsmipeveaTSP-TTQPSPLLPTQGAAGPGILLAPEQVATEA 408
                          330       340       350
                   ....*....|....*....|....*....|.
gi 564395488   716 RPCSHPTS-TPYTKADPTAACTSSPSLASSG 745
Cdd:pfam17823  409 TAGTASAGpTPRSSGDPKTLAMASCQLSTQG 439
HEAT COG1413
HEAT repeat [General function prediction only];
1077-1198 1.41e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 51.94  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488 1077 LLVQNLNSDDQAVVLKALRLApeGRLR-KDGLRALSSLLVHGNSKVMAAVStqlrsLSLGPVFRERALLCFLDQLEDEDV 1155
Cdd:COG1413    20 ALIAALADEDPDVRAAAARAL--GRLGdPRAVPALLEALKDPDPEVRAAAA-----EALGRIGDPEAVPALIAALKDEDP 92
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 564395488 1156 QTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQ 1198
Cdd:COG1413    93 EVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARALGR 135
PHA03247 PHA03247
large tegument protein UL36; Provisional
412-802 1.47e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 1.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  412 STPKPLVQQPEPLPVQVTFRRPESLSSGSMDEEPPLTPALVNGHAPYSRTLSHISEASVDAALTEAMEAVDLKCPAPGPS 491
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR 2684
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  492 PLVYPesthvehvSSVPPVADNGRSATSPalSTAGPAPTFIDPAssTQLDLVHKATDSGSSELPSITHTMASSTYSAVSP 571
Cdd:PHA03247 2685 RRAAR--------PTVGSLTSLADPPPPP--PTPEPAPHALVSA--TPLPPGPAAARQASPALPAAPAPPAVPAGPATPG 2752
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  572 INSVPGLTSTTVGSthkPMPSPLTSTGSIPsvtdsiQTTTSPTHTTPSPTHTTVSPTHSTPSPTHTTVSPSNAALSPSNA 651
Cdd:PHA03247 2753 GPARPARPPTTAGP---PAPAPPAAPAAGP------PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  652 TPSLSHSTTSPTQKATmsthtTSAVGPVQTTTsPISTTVSPSpsvdtaiissssavpsvpGPEAR--PCSHPTSTPYTKA 729
Cdd:PHA03247 2824 PAGPLPPPTSAQPTAP-----PPPPGPPPPSL-PLGGSVAPG------------------GDVRRrpPSRSPAAKPAAPA 2879
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  730 DPTAACTSSPSLASS---------GPKPLTSP--APDSLEQILKSPSSSPSSIVPEPQRSELSLALVAQ-APVPEATGGA 797
Cdd:PHA03247 2880 RPPVRRLARPAVSRStesfalppdQPERPPQPqaPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDpAGAGEPSGAV 2959

                  ....*
gi 564395488  798 GDRRL 802
Cdd:PHA03247 2960 PQPWL 2964
HEAT COG1413
HEAT repeat [General function prediction only];
1100-1215 6.51e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.01  E-value: 6.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488 1100 GRLR-KDGLRALSSLLVHGNSKV-MAAVStqlrslSLGPVFRERALLCFLDQLEDEDVQTRVAGCLALGCIKAPEGIEPL 1177
Cdd:COG1413    10 GRLGdPAAVPALIAALADEDPDVrAAAAR------ALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPAL 83
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 564395488 1178 VYLCQTDTEAVREAARQSLQQCGEEgqSAHRQLEESLD 1215
Cdd:COG1413    84 IAALKDEDPEVRRAAAEALGRLGDP--AAVPALLEALK 119
PHA03255 PHA03255
BDLF3; Provisional
518-667 8.77e-07

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 51.44  E-value: 8.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  518 TSPALSTAGPAPTFIDPASSTqldlVHKATDSGSSELPSITHTMASSTYSAVSPINSVPGLTSTTVGSTHKPMPS-PLTS 596
Cdd:PHA03255   20 TSLIWTSSGSSTASAGNVTGT----TAVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTSTGTTVTPvPTTS 95
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564395488  597 TGSIPSVTDSIQTTTSPTHTTPSPTHTTVSPTHSTPSPThtTVSPSNAALSPSNATPSLSHSTTSPTQKAT 667
Cdd:PHA03255   96 NASTINVTTKVTAQNITATEAGTGTSTGVTSNVTTRSSS--TTSATTRITNATTLAPTLSSKGTSNATKTT 164
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
562-754 1.69e-06

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 52.06  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  562 ASSTYSAVSPINSVPGLTSTTVGSTHKPMPSPLTSTGSIPSV--TDSIQTTTSPTHTTPSPTHTTVSPTHSTPSPTHTTV 639
Cdd:COG3469     1 SSSVSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVvsTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  640 SPSNAALSPSNATPSLSHSTTSPTQKATMSTHTTSAVGPVQTTTSPISTTVSPSPS------VDTAIISSSSAVPSVPGP 713
Cdd:COG3469    81 TATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSgasatsSAGSTTTTTTVSGTETAT 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 564395488  714 EARPCSHPTSTPYTKADPTAACTSSPSLASSGPKPLTSPAP 754
Cdd:COG3469   161 GGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTT 201
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
505-720 7.34e-06

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 50.14  E-value: 7.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  505 SSVPPVADNGRSATSPALSTAGPAPtfidpASSTQLDLVHKATDSGSSELPSITHTMASSTYSAVSPINSVPGLTSTTVG 584
Cdd:COG3469     1 SSSVSTAASPTAGGASATAVTLLGA-----AATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSST 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  585 STHKPMPSPLTSTGSIPSVTDSIQTTTSPTHTTPSPTHTTVSPTHSTPSPTHTTVSPSNAALSPSNATPSLSHSTTSPTQ 664
Cdd:COG3469    76 TSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSG 155
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  665 KATMSTHTTSAV----GPVQTTTSPISTTVSPSPSVDTAIISSSSAVPSVPGPEARPCSH 720
Cdd:COG3469   156 TETATGGTTTTSttttTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPKH 215
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
505-755 8.90e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 50.30  E-value: 8.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   505 SSVPPVADNGRSATSPALSTAGPAPTFIDPASSTQLDLVHKATDSGSSELPSITHTmaSSTYSAVSPinsVPGLTSTTVG 584
Cdd:pfam05109  522 SPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKT--SPTSAVTTP---TPNATSPTVG 596
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   585 STHKPMPS---PLTSTGSIPSVTDSIQTTTSPTHTTPSPTHTTVSPTHS-TPSPTHTTVSPSNAALSPS------NATPS 654
Cdd:pfam05109  597 ETSPQANTtnhTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSlRPSSISETLSPSTSDNSTShmplltSAHPT 676
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   655 LSHSTTSPTQKATMSTH-TTSAVGPVQTTTS----PISTTVSPSP-SVDTAIISSSSAVPSVPGPEARPCSHPTSTPY-T 727
Cdd:pfam05109  677 GGENITQVTPASTSTHHvSTSSPAPRPGTTSqasgPGNSSTSTKPgEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTgG 756
                          250       260
                   ....*....|....*....|....*...
gi 564395488   728 KADPTaacTSSPSLASSGPKPLTSPAPD 755
Cdd:pfam05109  757 KANST---TGGKHTTGHGARTSTEPTTD 781
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
486-697 2.22e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 48.60  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  486 PAPGPSPLVYPESTHVEHVSSVPPVADNGRSATSPALSTAGPAPTFI-DPASSTQLDLVHKATDSGSSELPSITHTMASS 564
Cdd:COG3469     1 SSSVSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGsVVVAASGSAGSGTGTTAASSTAATSSTTSTTA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  565 TYSAVSPINSVPGLTSTTVGSTHKPMPSPL----TSTGSIPSVTDSIQTTTSPTHTTPSPTHTTVSPTHSTPSPTHTTVS 640
Cdd:COG3469    81 TATAAAAAATSTSATLVATSTASGANTGTStvttTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETAT 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 564395488  641 PSNAALSPSNATPSLShSTTSPTqkatmSTHTTSAVGPVQTTTSPISTTVSPSPSVD 697
Cdd:COG3469   161 GGTTTTSTTTTTTSAS-TTPSAT-----TTATATTASGATTPSATTTATTTGPPTPG 211
HEAT COG1413
HEAT repeat [General function prediction only];
1133-1202 2.44e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 45.39  E-value: 2.44e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488 1133 SLGPVFRERALLCFLDQLEDEDVQTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQCGEE 1202
Cdd:COG1413     8 ALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDP 77
PHA03255 PHA03255
BDLF3; Provisional
628-745 3.24e-05

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 46.82  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  628 THSTPSPTHTTVSPSNAALSPSNATPSLSHSTTSPTQKATMSTHTTSAVGPVQTTT-SPISTTVSPSPSVDTAIISSSSA 706
Cdd:PHA03255   25 TSSGSSTASAGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTvTSTGTTVTPVPTTSNASTINVTT 104
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 564395488  707 VPSVPGPEARPCSHPTSTPYTKADPTA-------------ACTSSPSLASSG 745
Cdd:PHA03255  105 KVTAQNITATEAGTGTSTGVTSNVTTRsssttsattritnATTLAPTLSSKG 156
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
1107-1197 2.33e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 41.17  E-value: 2.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  1107 LRALSSLLVHGNSKVMAAVSTQlrslSLGPVFRERALLCFLDQLEDEDVQTRVAGCLALGCIKAPEGIEPLVYLCQTDTE 1186
Cdd:pfam13646    1 LPALLQALLRDPDPEVRAAAIR----ALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLRDDDD 76
                           90
                   ....*....|..
gi 564395488  1187 A-VREAARQSLQ 1197
Cdd:pfam13646   77 DvVRAAAAEALA 88
HR1_PKN1_3 cd11636
Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein ...
152-219 5.59e-04

Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1; PKN1, also called PKNalpha or Protein-kinase C-related kinase 1 (PRK1), is a serine/threonine protein kinase that is activated by the Rho family of small GTPases, and by fatty acids such as arachidonic and linoleic acids. It is expressed ubiquitously and is the most abundant PKN isoform in neurons. PKN1 is implicated in a variety of functions including cytoskeletal reorganization, cardiac cell survival, cell adhesion, and glucose transport, among others. PKN1 contains three HR1 domains, a C2 domain, and a kinase domain. This model characterizes the third HR1 domain of PKN1. HR1 domains are anti-parallel coiled-coil (ACC) domains that bind small GTPases from the Rho family; PKN1 binds the GTPases RhoA, RhoB, and RhoC, and can also interact weakly with Rac.


Pssm-ID: 212026  Cd Length: 74  Bit Score: 39.57  E-value: 5.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564395488  152 KIDELYEAYCVQRRLRDGAYNMVRAYSTGSPGSREArdsLAEATRGHREYTESMCLLENELEAQLGEF 219
Cdd:cd11636    10 RIEELRHHFRVEHAVAEGAKNVLRLLGAGKAQDRKA---ISEAQSKLSESSQKLDLLRVSLEQRLVEL 74
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
432-819 6.26e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.39  E-value: 6.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  432 RPESLSSGSMDEEPPltPALVNGHAPYSRTLSH-ISEASVDAALTEAMEAVDLKCPAPGPSPLV-YPESTHVEHVSSVPP 509
Cdd:PHA03307   18 GEFFPRPPATPGDAA--DDLLSGSQGQLVSDSAeLAAVTVVAGAAACDRFEPPTGPPPGPGTEApANESRSTPTWSLSTL 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  510 VADNGRSATSP----ALSTAGPAPTFID--PASSTQLDLVHKATDSGSSELPSITHTMASSTYSAVSPINSVPGLTSTTV 583
Cdd:PHA03307   96 APASPAREGSPtppgPSSPDPPPPTPPPasPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALP 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  584 gsthKPMPSPLTSTGSIPSVTDSIQTTTSPTHTTPSPTHTTVSPTHSTPSPthttVSPSNAALSPSNATPSLSHSTTSPT 663
Cdd:PHA03307  176 ----LSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAP----APGRSAADDAGASSSDSSSSESSGC 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  664 QKATMSTHTTSAVGPVQTTTSPISTTVSPSPSVDTAIISSSSAVPSVPGP--EARPCSHPTSTPYTKAD----PTAACTS 737
Cdd:PHA03307  248 GWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSpsPSSPGSGPAPSSPRASSssssSRESSSS 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  738 SPSLASSGPKPLTSPAPDSLEQILKSPSSSPSSIVPEPQRSElslALVAQAPVPEATGGAGDRRleealRTLMAALDDYR 817
Cdd:PHA03307  328 STSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRP---RPSRAPSSPAASAGRPTRR-----RARAAVAGRAR 399

                  ..
gi 564395488  818 GQ 819
Cdd:PHA03307  400 RR 401
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
625-698 1.97e-03

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 42.53  E-value: 1.97e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564395488  625 VSPTHSTPSPTHTTVSPSNAALSPSNATPSLSHSTTSPTQKATMSTHTTSAVGPV-QTTTSPISTTVSPSPSVDT 698
Cdd:PRK11907   32 VTTTPATSTEAEQTTPVESDATEEADNTETPVAATTAAEAPSSSETAETSDPTSEaTDTTTSEARTVTPAATETS 106
PHA03247 PHA03247
large tegument protein UL36; Provisional
359-754 2.38e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 2.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  359 SQSPPDTPSLREQAFYNMLRRQEELENGTAWSLSSESSDDSSSPQLSGTARYSSTPKPLVQQPEPLPvqvTFRRPE---- 434
Cdd:PHA03247 2615 SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQ---RPRRRAarpt 2691
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  435 --SLSSGSMDEEPPLTPalvnghAPYSRTLSHISEASVDAALTEAMEAVDLKCPAPGPSPLVyPESTHVEHVSSVPPVAD 512
Cdd:PHA03247 2692 vgSLTSLADPPPPPPTP------EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG-PATPGGPARPARPPTTA 2764
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  513 NGRSATSPALSTAGPAPTFIDPA-SSTQLDLVHKATDSGSSELPSITHTMASSTYSAVSPINSVPGLTSTTVGSTHK--- 588
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAvASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPppg 2844
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  589 PMPSPLTSTGSIPSVTDsiqtttspTHTTPSPTHTTVSPTHSTPSPTHTTVSPSNAALSPSNATPSLSHSTTSPTQKATM 668
Cdd:PHA03247 2845 PPPPSLPLGGSVAPGGD--------VRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPP 2916
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488  669 STHTTSAVGPVQTTTSPISTTVSPSPSVDTAIISSSSAVPSVPGPEARPCSHPTSTPYTKADPTAACTSSPSLASSGPKP 748
Cdd:PHA03247 2917 PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPL 2996

                  ....*.
gi 564395488  749 LTSPAP 754
Cdd:PHA03247 2997 TGHSLS 3002
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
1150-1215 2.94e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 38.09  E-value: 2.94e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564395488  1150 LEDEDVQTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQCGEEGQSAHrqLEESLD 1215
Cdd:pfam13646    9 LRDPDPEVRAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPA--LLELLR 72
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
412-752 6.00e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.06  E-value: 6.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   412 STPKPLVQQPEPlpvQVTFRRPESLSS--GSMDEEPPLTPALVNGHAPYSRTLSHISEASVdAALTEAMEAVDLKCPAP- 488
Cdd:pfam05109  514 TTPTPNATSPTP---AVTTPTPNATSPtlGKTSPTSAVTTPTPNATSPTPAVTTPTPNATI-PTLGKTSPTSAVTTPTPn 589
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   489 GPSPLV---YPESTHVEHV----SSVPPVADNGRSATSPA------LSTAGPAPTFIDPASSTQlDLVHKATDSGSSELP 555
Cdd:pfam05109  590 ATSPTVgetSPQANTTNHTlggtSSTPVVTSPPKNATSAVttgqhnITSSSTSSMSLRPSSISE-TLSPSTSDNSTSHMP 668
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   556 SIT--HTMASSTYSAVSPINsvpglTSTTVGSTHKPMPSPLTSTGSipsvtdsiqtttspthttpspthttvspthSTPS 633
Cdd:pfam05109  669 LLTsaHPTGGENITQVTPAS-----TSTHHVSTSSPAPRPGTTSQA------------------------------SGPG 713
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   634 PTHTTVSPSNAALS----PSNATpslshSTTSPTQKATMSTHTTSAVGPVQTTTSPISTTvspspsvdtaiissssavps 709
Cdd:pfam05109  714 NSSTSTKPGEVNVTkgtpPKNAT-----SPQAPSGQKTAVPTVTSTGGKANSTTGGKHTT-------------------- 768
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 564395488   710 vpGPEARPCSHPT-------STPYTKADPTaacTSSPSLASSGPKP---LTSP 752
Cdd:pfam05109  769 --GHGARTSTEPTtdyggdsTTPRTRYNAT---TYLPPSTSSKLRPrwtFTSP 816
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
568-754 9.78e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 39.94  E-value: 9.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   568 AVSPINSVPGLTSTTVGSTHKPMPSPLT-------------STGSIPSVTDSIQTTTSPTHTTPSPTHTTVSPTHSTPSP 634
Cdd:pfam17823   46 AVPRADNKSSEQ*NFCAATAAPAPVTLTkgtsaahlnstevTAEHTPHGTDLSEPATREGAADGAASRALAAAASSSPSS 125
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395488   635 THTTVSPSNAALspsnatPSLSHSTtsPTQKATMSTHTTSAVGPVQTTTSPISTTVSPSPSVDTAIISSSSAVPSVPGPE 714
Cdd:pfam17823  126 AAQSLPAAIAAL------PSEAFSA--PRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTT 197
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 564395488   715 ARPCSHPTSTPYTKADPTAACTSSPSLASSGPK-PLTSPAP 754
Cdd:pfam17823  198 AASSAPATLTPARGISTAATATGHPAAGTALAAvGNSSPAA 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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