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Conserved domains on  [gi|564390642|ref|XP_006253737|]
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methylglutaconyl-CoA hydratase, mitochondrial isoform X1 [Rattus norvegicus]

Protein Classification

Clp protease/crotonase-like domain-containing protein( domain architecture ID 581041)

Clp protease/crotonase-like domain-containing protein similar to Oryza sativa enoyl-CoA delta isomerase which plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
crotonase-like super family cl23717
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 62-284 3.13e-78

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


The actual alignment was detected with superfamily member PLN02600:

Pssm-ID: 474030 [Multi-domain]  Cd Length: 251  Bit Score: 237.78  E-value: 3.13e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  62 NRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGPFVSKIR--- 138
Cdd:PLN02600   2 DSGIVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGADLKERRKMSPSEVQKFVNSLRstf 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 139 -----------AVINDIA-----------------SSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDG 190
Cdd:PLN02600  82 sslealsiptiAVVEGAAlggglelalscdlricgEEAVFGLPETGLAIIPGAGGTQRLPRLVGRSRAKELIFTGRRIGA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 191 QEAKAVGLISHVLeqnQEGDAaYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGL 270
Cdd:PLN02600 162 REAASMGLVNYCV---PAGEA-YEKALELAQEINQKGPLAIKMAKKAINEGSEVDMASGLEIEEECYEQVLKTKDRLEGL 237

                        250
                 ....*....|....
gi 564390642 271 LAFKEKRPPRYKGE 284
Cdd:PLN02600 238 AAFAEKRKPVYTGK 251
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
 62-284 3.13e-78

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 237.78  E-value: 3.13e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  62 NRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGPFVSKIR--- 138
Cdd:PLN02600   2 DSGIVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGADLKERRKMSPSEVQKFVNSLRstf 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 139 -----------AVINDIA-----------------SSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDG 190
Cdd:PLN02600  82 sslealsiptiAVVEGAAlggglelalscdlricgEEAVFGLPETGLAIIPGAGGTQRLPRLVGRSRAKELIFTGRRIGA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 191 QEAKAVGLISHVLeqnQEGDAaYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGL 270
Cdd:PLN02600 162 REAASMGLVNYCV---PAGEA-YEKALELAQEINQKGPLAIKMAKKAINEGSEVDMASGLEIEEECYEQVLKTKDRLEGL 237

                        250
                 ....*....|....
gi 564390642 271 LAFKEKRPPRYKGE 284
Cdd:PLN02600 238 AAFAEKRKPVYTGK 251
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 60-278 4.25e-51

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 168.04  E-value: 4.25e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  60 EENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKE--------RAKMHSSEVG 131
Cdd:COG1024    4 EREGGVATITLNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKElaaaadpeEARAFARGLQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 132 PFVSKIR-------AVIN--------------DI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARV 187
Cdd:COG1024   83 RLFRALRrlpkpviAAVNgaalggglelalacDLriaAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELLLTGRR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 188 LDGQEAKAVGLISHVLEQnqegDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRL 267
Cdd:COG1024  163 IDAEEALELGLVNRVVPD----DELLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELEAEAFAELFASEDAR 238

                        250
                 ....*....|.
gi 564390642 268 EGLLAFKEKRP 278
Cdd:COG1024  239 EGIAAFLEKRK 249
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 60-283 1.12e-37

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 133.64  E-value: 1.12e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642   60 EENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAGADLKERAKMH-------SSEVGP 132
Cdd:pfam00378   1 EINAGVAVITLNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTG-GDKAFCAGADLKEMYGEGpahqalyRENVLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  133 FVSKIR-------AVIN--------------DI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVL 188
Cdd:pfam00378  80 LWTLLYtcpkpviAAVNgyaigggcelalacDIiiaADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  189 DGQEAKAVGLISHVLEQNQegdaAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLE 268
Cdd:pfam00378 160 SAQEALKWGLVDKVVPEDQ----LLDEARELAEKLAEKSPAALAQLKKALNAKLEDALPTQLEAEARLFYSTFSKDDIIE 235

                         250
                  ....*....|....*
gi 564390642  269 GLLAFKEKRPPRYKG 283
Cdd:pfam00378 236 GLQAFLEKRKPPWED 250
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 60-222 3.78e-35

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 125.37  E-value: 3.78e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  60 EENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKM---------HSSEV 130
Cdd:cd06558    4 ERDGGVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKELAALsdageearaFIREL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 131 GPFVSKIR-------AVIN--------------DI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSAR 186
Cdd:cd06558   83 QELLRALLrlpkpviAAVNgaalggglelalacDIriaAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELLLTGR 162

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 564390642 187 VLDGQEAKAVGLISHVLEQnqegDAAYRKALDLARE 222
Cdd:cd06558  163 RISAEEALELGLVDEVVPD----EELLAAALELARR 194
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 57-262 2.41e-12

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 66.78  E-value: 2.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642   57 HLEEENRG-IVVLGINRAYGK-NSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERA----------- 123
Cdd:TIGR02441  14 HRHYEVKGdVAVVKIDSPNSKvNTLSKELFAEFKEVMNELWTNEAIKSAVLISGKPGSFVAGADIQMIAacktaqevtql 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  124 ---------KMHSSEvGPFVSKI-----------------RAVINDiaSSAKMGLVETKLAIIPGGGGTQRLPRAIGMAL 177
Cdd:TIGR02441  94 sqegqemfeRIEKSQ-KPIVAAIsgsclggglelalachyRIATKD--RKTLLGLPEVMLGLLPGAGGTQRLPKLTGVPA 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  178 AKELIFSARVLDGQEAKAVGLISHVLEQNQEGdaaYRKALDLAREFLPQgpVAMRVAKLAINQGMEVDLVTGLAIEEACY 257
Cdd:TIGR02441 171 ALDMMLTGKKIRADRAKKMGIVDQLVDPLGPG---LKPAEENTIEYLEE--VAVKFAQGLANGKLSINRDKGLVHKITQY 245


                  ....*
gi 564390642  258 AQTIS 262
Cdd:TIGR02441 246 VMTNP 250
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
 62-284 3.13e-78

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 237.78  E-value: 3.13e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  62 NRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGPFVSKIR--- 138
Cdd:PLN02600   2 DSGIVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGADLKERRKMSPSEVQKFVNSLRstf 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 139 -----------AVINDIA-----------------SSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDG 190
Cdd:PLN02600  82 sslealsiptiAVVEGAAlggglelalscdlricgEEAVFGLPETGLAIIPGAGGTQRLPRLVGRSRAKELIFTGRRIGA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 191 QEAKAVGLISHVLeqnQEGDAaYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGL 270
Cdd:PLN02600 162 REAASMGLVNYCV---PAGEA-YEKALELAQEINQKGPLAIKMAKKAINEGSEVDMASGLEIEEECYEQVLKTKDRLEGL 237

                        250
                 ....*....|....
gi 564390642 271 LAFKEKRPPRYKGE 284
Cdd:PLN02600 238 AAFAEKRKPVYTGK 251
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 62-284 3.72e-73

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 225.00  E-value: 3.72e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  62 NRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGPFVSKIRAVI 141
Cdd:PRK07657  11 TPHVVKITLNRPRAANALSLALLEELQNILTQINEEANVRVVILTGAGEKAFCAGADLKERAGMNEEQVRHAVSLIRTTM 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 142 NDI-------------------------------ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDG 190
Cdd:PRK07657  91 EMVeqlpqpviaaingialggglelalacdfriaAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISA 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 191 QEAKAVGLISHVLEQNQEGDaayrKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGL 270
Cdd:PRK07657 171 QEAKEIGLVEFVVPAHLLEE----KAIEIAEKIASNGPIAVRQAKEAISNGIQVDLHTGLQIEKQAYEGTIPTKDRLEGL 246

                        250
                 ....*....|....
gi 564390642 271 LAFKEKRPPRYKGE 284
Cdd:PRK07657 247 QAFKEKRKPMYKGE 260
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 60-278 4.25e-51

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 168.04  E-value: 4.25e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  60 EENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKE--------RAKMHSSEVG 131
Cdd:COG1024    4 EREGGVATITLNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKElaaaadpeEARAFARGLQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 132 PFVSKIR-------AVIN--------------DI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARV 187
Cdd:COG1024   83 RLFRALRrlpkpviAAVNgaalggglelalacDLriaAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELLLTGRR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 188 LDGQEAKAVGLISHVLEQnqegDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRL 267
Cdd:COG1024  163 IDAEEALELGLVNRVVPD----DELLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELEAEAFAELFASEDAR 238

                        250
                 ....*....|.
gi 564390642 268 EGLLAFKEKRP 278
Cdd:COG1024  239 EGIAAFLEKRK 249
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
60-283 8.23e-43

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 147.20  E-value: 8.23e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  60 EENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGPF------ 133
Cdd:PRK05809   9 EKEGHIAVVTINRPKALNALNSETLKELDTVLDDIENDDNVYAVILTGAGEKAFVAGADISEMKDLNEEEGRKFgllgnk 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 134 -------VSK-IRAVIND----------------IASS-AKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVL 188
Cdd:PRK05809  89 vfrklenLDKpVIAAINGfalgggcelsmacdirIASEkAKFGQPEVGLGITPGFGGTQRLARIVGPGKAKELIYTGDMI 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 189 DGQEAKAVGLISHVLEQNQEGDAAYRkaldLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLE 268
Cdd:PRK05809 169 NAEEALRIGLVNKVVEPEKLMEEAKA----LANKIAANAPIAVKLCKDAINRGMQVDIDTAVAIEAEDFGECFSTEDQTE 244

                        250
                 ....*....|....*
gi 564390642 269 GLLAFKEKRPPRYKG 283
Cdd:PRK05809 245 GMTAFVEKREKNFKN 259
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
 64-283 1.33e-38

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 136.05  E-value: 1.33e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  64 GIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAK------------MHSSEVG 131
Cdd:PRK09674  11 RVLLLTLNRPEARNALNNALLTQLVNELEAAATDTSIGVCVITGN-ARFFAAGADLNEMAEkdlaatlndprpQLWQRLQ 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 132 PFVSKIRAVINDIA-----------------SSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDGQEAK 194
Cdd:PRK09674  90 AFNKPLIAAVNGYAlgagcelallcdiviagENARFGLPEITLGIMPGAGGTQRLIRSVGKSLASQMVLTGESITAQQAQ 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 195 AVGLISHVLEQnqegDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGLLAFK 274
Cdd:PRK09674 170 QAGLVSEVFPP----ELTLERALQLASKIARHSPLALRAAKQALRQSQEVDLQAGLAQERQLFTLLAATEDRHEGISAFL 245


                 ....*....
gi 564390642 275 EKRPPRYKG 283
Cdd:PRK09674 246 EKRTPDFKG 254
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 60-283 1.12e-37

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 133.64  E-value: 1.12e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642   60 EENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAGADLKERAKMH-------SSEVGP 132
Cdd:pfam00378   1 EINAGVAVITLNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTG-GDKAFCAGADLKEMYGEGpahqalyRENVLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  133 FVSKIR-------AVIN--------------DI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVL 188
Cdd:pfam00378  80 LWTLLYtcpkpviAAVNgyaigggcelalacDIiiaADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  189 DGQEAKAVGLISHVLEQNQegdaAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLE 268
Cdd:pfam00378 160 SAQEALKWGLVDKVVPEDQ----LLDEARELAEKLAEKSPAALAQLKKALNAKLEDALPTQLEAEARLFYSTFSKDDIIE 235

                         250
                  ....*....|....*
gi 564390642  269 GLLAFKEKRPPRYKG 283
Cdd:pfam00378 236 GLQAFLEKRKPPWED 250
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 49-283 1.41e-35

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 128.06  E-value: 1.41e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  49 TEDELRVrHLEEenrGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAGADLKE------R 122
Cdd:PRK06688   3 MVTDLLV-ELED---GVLTITINRPDKKNALTAAMYQALADALEAAATDPAVRVVVLTG-AGRAFSAGGDIKDfpkappK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 123 AKMHSSEVGPFVSKIR-------AVIN--------------DI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALA 178
Cdd:PRK06688  78 PPDELAPVNRFLRAIAalpkpvvAAVNgpavgvgvslalacDLvyaSESAKFSLPFAKLGLCPDAGGSALLPRLIGRARA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 179 KELIFSARVLDGQEAKAVGLISHVLEQNqEGDAayrKALDLAREfLPQGP-VAMRVAKLAINQGMEVDLVTGLAIEEACY 257
Cdd:PRK06688 158 AEMLLLGEPLSAEEALRIGLVNRVVPAA-ELDA---EADAQAAK-LAAGPaSALRYTKRAINAATLTELEEALAREAAGF 232

                        250       260
                 ....*....|....*....|....*.
gi 564390642 258 AQTISTKDRLEGLLAFKEKRPPRYKG 283
Cdd:PRK06688 233 GRLLRTPDFREGATAFIEKRKPDFTG 258
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 60-222 3.78e-35

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 125.37  E-value: 3.78e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  60 EENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKM---------HSSEV 130
Cdd:cd06558    4 ERDGGVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKELAALsdageearaFIREL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 131 GPFVSKIR-------AVIN--------------DI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSAR 186
Cdd:cd06558   83 QELLRALLrlpkpviAAVNgaalggglelalacDIriaAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELLLTGR 162

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 564390642 187 VLDGQEAKAVGLISHVLEQnqegDAAYRKALDLARE 222
Cdd:cd06558  163 RISAEEALELGLVDEVVPD----EELLAAALELARR 194
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
 50-284 1.64e-33

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 122.85  E-value: 1.64e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  50 EDELRVRHLEEenrGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMHSSE 129
Cdd:PRK08138   6 TDVVLLERPAD---GVALLRLNRPEARNALNMEVRQQLAEHFTELSEDPDIRAIVLTGG-EKVFAAGADIKEFATAGAIE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 130 V----------------GPFVSKIR----------AVINDI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKE 180
Cdd:PRK08138  82 MylrhteryweaiaqcpKPVIAAVNgyalgggcelAMHADIivaGESASFGQPEIKVGLMPGAGGTQRLVRAVGKFKAMR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 181 LIFSARVLDGQEAKAVGLISHVLEQNQegdaAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQT 260
Cdd:PRK08138 162 MALTGCMVPAPEALAIGLVSEVVEDEQ----TLPRALELAREIARMPPLALAQIKEVVLAGADAPLDAALALERKAFQLL 237

                        250       260
                 ....*....|....*....|....
gi 564390642 261 ISTKDRLEGLLAFKEKRPPRYKGE 284
Cdd:PRK08138 238 FDSEDQKEGMDAFLEKRKPAYKGK 261
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 64-284 1.95e-33

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 122.44  E-value: 1.95e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  64 GIVVLGINRAYGkNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEvpG-IFCAGADLKERAKMHSSE------------- 129
Cdd:PRK07658  11 HVAVITLNHPPA-NALSSQVLHELSELLDQVEKDDNVRVVVIHGE--GrFFSAGADIKEFTSVTEAEqatelaqlgqvtf 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 130 --VGPFVSKIRAVINDIA-----------------SSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDG 190
Cdd:PRK07658  88 erVEKFSKPVIAAIHGAAlggglelamschirfatESAKLGLPELNLGLIPGFAGTQRLPRYVGKAKALEMMLTSEPITG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 191 QEAKAVGLISHVLEQNQegdaAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGL 270
Cdd:PRK07658 168 AEALKWGLVNGVFPEET----LLDDAKKLAKKIAGKSPATTRAVLELLQTTKSSSYYEGVKREAKIFGEVFTSEDAKEGV 243

                        250
                 ....*....|....
gi 564390642 271 LAFKEKRPPRYKGE 284
Cdd:PRK07658 244 QAFLEKRKPSFSGK 257
PRK05862 PRK05862
enoyl-CoA hydratase; Provisional
 61-282 4.48e-32

enoyl-CoA hydratase; Provisional


Pssm-ID: 180295 [Multi-domain]  Cd Length: 257  Bit Score: 118.99  E-value: 4.48e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  61 ENRGIV-VLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIR-SEvpGIFCAGADLKERAKMHSSEV--GPFVS- 135
Cdd:PRK05862   9 ETRGRVgLITLNRPKALNALNDALMDELGAALAAFDADEGIGAIVITgSE--KAFAAGADIKEMADLSFMDVykGDYITn 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 136 -----KIR------------------AVINDI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLD 189
Cdd:PRK05862  87 wekvaRIRkpviaavagyalgggcelAMMCDIiiaADTAKFGQPEIKLGVLPGMGGSQRLTRAVGKAKAMDLCLTGRMMD 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 190 GQEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPqgpvAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEG 269
Cdd:PRK05862 167 AAEAERAGLVSRVVPADKLLDEALAAATTIASFSLP----AVMMAKEAVNRAYETTLAEGLLFERRLFHSLFATEDQKEG 242

                        250
                 ....*....|...
gi 564390642 270 LLAFKEKRPPRYK 282
Cdd:PRK05862 243 MAAFVEKRKPVFK 255
PRK07799 PRK07799
crotonase/enoyl-CoA hydratase family protein;
57-284 2.44e-29

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181122 [Multi-domain]  Cd Length: 263  Bit Score: 112.12  E-value: 2.44e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  57 HLEEENRG-IVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIrSEVPGIFCAGADLKERAKMHSSEV---GP 132
Cdd:PRK07799   6 HALVEQRGhTLIVTMNRPEARNALSTEMLRIMVDAWDRVDNDPDIRSCIL-TGAGGAFCAGMDLKAATKKPPGDSfkdGS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 133 F-VSKIRAVI---------------------------NDI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKEL 181
Cdd:PRK07799  85 YdPSRIDALLkgrrltkpliaavegpaiaggteilqgTDIrvaGESAKFGISEAKWSLFPMGGSAVRLVRQIPYTVACDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 182 IFSARVLDGQEAKAVGLISHVLEQNQegdaAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTI 261
Cdd:PRK07799 165 LLTGRHITAAEAKEIGLIGHVVPDGQ----ALDKALELAELINANGPLAVQAILRTIRETEGMHENEAFKIDTKIGIPVF 240

                        250       260
                 ....*....|....*....|...
gi 564390642 262 STKDRLEGLLAFKEKRPPRYKGE 284
Cdd:PRK07799 241 LSEDAKEGPRAFAEKRAPNFQGR 263
PRK09245 PRK09245
crotonase/enoyl-CoA hydratase family protein;
58-284 4.98e-26

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181723  Cd Length: 266  Bit Score: 103.13  E-value: 4.98e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  58 LEEENRGIVVLGINRAYGKNSLSKN-LLKMLSKAVDALKSDKKVRTIIIRSEVPgIFCAGADLKE-RAKMHSSEVGPFvs 135
Cdd:PRK09245   6 LVERDGHIVTLTMNRPETRNALSDNdAVDALVAACAAINADRSVRAVILTGAGT-AFSSGGNVKDmRARVGAFGGSPA-- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 136 KIR----------------------AVIN--------------DI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMA 176
Cdd:PRK09245  83 DIRqgyrhgiqriplalynlevpviAAVNgpaigagcdlacmcDIriaSETARFAESFVKLGLIPGDGGAWLLPRIIGMA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 177 LAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAayrkALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEAc 256
Cdd:PRK09245 163 RAAEMAFTGDAIDAATALEWGLVSRVVPADQLLPA----ARALAERIAANPPHALRLTKRLLREGQHASLDTLLELSAA- 237

                        250       260       270
                 ....*....|....*....|....*....|
gi 564390642 257 yAQTIS--TKDRLEGLLAFKEKRPPRYKGE 284
Cdd:PRK09245 238 -YQALAhhTADHREAVDAFLEKRPPVFTGR 266
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
54-282 1.44e-25

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 101.88  E-value: 1.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  54 RVRhLEEENrGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMHSSEVGPF 133
Cdd:PRK07509   4 RVS-VTIED-GIADVRLNRPDKMNALDFAMFEELIATIKRLKKDRGIRAVILSGE-GGAFCAGLDVKSVASSPGNAVKLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 134 VSKIR---------------------AVIN--------------DI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGM 175
Cdd:PRK07509  81 FKRLPgnanlaqrvslgwrrlpvpviAALEgvcfggglqialgaDIriaAPDTKLSIMEAKWGLVPDMAGTVSLRGLVRK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 176 ALAKELIFSARVLDGQEAKAVGLISHVLEQnqegdaAYRKALDLAREFLPQGPVAMRVAKLAINQgMEVDLVTGLAIEEA 255
Cdd:PRK07509 161 DVARELTYTARVFSAEEALELGLVTHVSDD------PLAAALALAREIAQRSPDAIAAAKRLINR-SWTASVRALLARES 233

                        250       260
                 ....*....|....*....|....*...
gi 564390642 256 CY-AQTISTKDRLEGLLAFKEKRPPRYK 282
Cdd:PRK07509 234 VEqIRLLLGKNQKIAVKAQMKKRAPKFL 261
PRK09076 PRK09076
enoyl-CoA hydratase; Provisional
 56-282 9.74e-25

enoyl-CoA hydratase; Provisional


Pssm-ID: 236373 [Multi-domain]  Cd Length: 258  Bit Score: 99.61  E-value: 9.74e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  56 RHLEEENRG-IVVLGINRAYGkNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERA---KMHSSEV- 130
Cdd:PRK09076   3 IELDLEIDGhVAILTLNNPPA-NTWTADSLQALKQLVLELNADKDVYALVITGDGEKFFSAGADLNLFAdgdKAVAREMa 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 131 ----GPF--VSKIR----AVINDIA-----------------SSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIF 183
Cdd:PRK09076  82 rrfgEAFeaLSAFRgvsiAAINGYAmggglecalacdiriaeEQAQMALPEASVGLLPCAGGTQNLPWLVGEGWAKRMIL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 184 SARVLDGQEAKAVGLISHVLEQNQEGDAayrkALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIST 263
Cdd:PRK09076 162 CGERVDAATALRIGLVEEVVEKGEAREA----ALALAQKVANQSPSAVAACKTLIQAARNGPRAAALALERELFVDLFDT 237

                        250
                 ....*....|....*....
gi 564390642 264 KDRLEGLLAFKEKRPPRYK 282
Cdd:PRK09076 238 EDQREGVNAFLEKRAPQWK 256
PRK08252 PRK08252
crotonase/enoyl-CoA hydratase family protein;
49-284 3.28e-24

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181325 [Multi-domain]  Cd Length: 254  Bit Score: 98.14  E-value: 3.28e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  49 TEDELRVrhleEENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIrSEVPGIFCAGADLKERAKMHSS 128
Cdd:PRK08252   1 MSDEVLV----ERRGRVLIITINRPEARNAVNAAVAQGLAAALDELDADPDLSVGIL-TGAGGTFCAGMDLKAFARGERP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 129 EV-----GPFVSK------IRAV-------------INDI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKEL 181
Cdd:PRK08252  76 SIpgrgfGGLTERpprkplIAAVegyalaggfelalACDLivaARDAKFGLPEVKRGLVAAGGGLLRLPRRIPYHIAMEL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 182 IFSARVLDGQEAKAVGLISHVLEQNQEGDAayrkALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTI 261
Cdd:PRK08252 156 ALTGDMLTAERAHELGLVNRLTEPGQALDA----ALELAERIAANGPLAVAASKRIVVESGDWSEDEMFARQRELIAPVF 231

                        250       260
                 ....*....|....*....|...
gi 564390642 262 STKDRLEGLLAFKEKRPPRYKGE 284
Cdd:PRK08252 232 TSADAKEGATAFAEKRAPVWTGK 254
PRK05980 PRK05980
crotonase/enoyl-CoA hydratase family protein;
58-281 4.43e-24

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180335 [Multi-domain]  Cd Length: 260  Bit Score: 97.91  E-value: 4.43e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  58 LEEENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKE---------------- 121
Cdd:PRK05980   6 LIEIRDGIALLTLNRPEKLNALNYALIDRLLARLDAIEVDESVRAVILTGAGDRAFSAGADIHEfsasvaagadvalrdf 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 122 --RAKMHSSEVGPFVSKIRAVINDIA-----------------SSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELI 182
Cdd:PRK05980  86 vrRGQAMTARLEAFPKPVIAAVNGLAfgggceiteavhlaiasERALFAKPEIRLGMPPTFGGTQRLPRLAGRKRALELL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 183 FSARVLDGQEAKAVGLISHVLEQnqegDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIS 262
Cdd:PRK05980 166 LTGDAFSAERALEIGLVNAVVPH----EELLPAARALARRIIRHSPVAVAAILTAVTRGLNLSIAEGLLIESEQFARMAG 241

                        250
                 ....*....|....*....
gi 564390642 263 TKDRLEGLLAFKEKRPPRY 281
Cdd:PRK05980 242 SADLREGLAAWIERRRPAY 260
PRK06494 PRK06494
enoyl-CoA hydratase; Provisional
 64-283 5.91e-24

enoyl-CoA hydratase; Provisional


Pssm-ID: 180591 [Multi-domain]  Cd Length: 259  Bit Score: 97.42  E-value: 5.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  64 GIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGP----------- 132
Cdd:PRK06494  13 HVTIVTLNRPEVMNALHLDAHFELEEVFDDFAADPEQWVAIVTGAGDKAFSAGNDLKEQAAGGKRGWPEsgfggltsrfd 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 133 FVSKIRAVIN--------------DI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDGQEAKA 195
Cdd:PRK06494  93 LDKPIIAAVNgvamgggfelalacDLivaAENATFALPEPRVGLAALAGGLHRLPRQIGLKRAMGMILTGRRVTAREGLE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 196 VGLISHVLEQnQEGDAAyrkALDLAREFLPQGPVAMRVAKLAINQGMEVDLvtglaiEEACYAQT--------ISTKDRL 267
Cdd:PRK06494 173 LGFVNEVVPA-GELLAA---AERWADDILACSPLSIRASKQAVYRGLEVSL------EEAITAQRdypavearRASQDYI 242

                        250
                 ....*....|....*.
gi 564390642 268 EGLLAFKEKRPPRYKG 283
Cdd:PRK06494 243 EGPKAFAEKRPPRWKG 258
PRK06127 PRK06127
enoyl-CoA hydratase; Provisional
 64-283 1.49e-20

enoyl-CoA hydratase; Provisional


Pssm-ID: 235705  Cd Length: 269  Bit Score: 88.61  E-value: 1.49e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  64 GIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKM-----------HSSEVG- 131
Cdd:PRK06127  20 GLGRITFNNPARHNAMSLDMWEALPQALAAAEDDDAIRVVVLTGAGEKAFVSGADISQFEESrsdaeavaayeQAVEAAq 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 132 --------PFVSKIR----------AVINDI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDG 190
Cdd:PRK06127 100 aaladyakPTIACIRgycigggmgiALACDIriaAEDSRFGIPAARLGLGYGYDGVKNLVDLVGPSAAKDLFYTARRFDA 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 191 QEAKAVGLISHVLEqNQEGDAAyrkALDLAREFLPQGPVAMRVAKLAINQ----GMEVDLVTGLAIEEACYAqtisTKDR 266
Cdd:PRK06127 180 AEALRIGLVHRVTA-ADDLETA---LADYAATIAGNAPLTLRAAKRAIAEllkdEPERDMAACQALVAACFD----SEDY 251

                        250
                 ....*....|....*..
gi 564390642 267 LEGLLAFKEKRPPRYKG 283
Cdd:PRK06127 252 REGRAAFMEKRKPVFKG 268
PRK08260 PRK08260
enoyl-CoA hydratase; Provisional
 64-283 1.34e-19

enoyl-CoA hydratase; Provisional


Pssm-ID: 236206 [Multi-domain]  Cd Length: 296  Bit Score: 86.21  E-value: 1.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  64 GIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIirseVPG---IFCAGADLKERAK-------------MHS 127
Cdd:PRK08260  13 GIATITLNRPDKLNAFTVTMARELIEAFDAADADDAVRAVI----VTGagrAFCAGADLSAGGNtfdldaprtpveaDEE 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 128 SEVGPFVSKIR------------------AVIN--------------DI--AS-SAKMGLVETKLAIIPGGGGTQRLPRA 172
Cdd:PRK08260  89 DRADPSDDGVRdgggrvtlrifdslkpviAAVNgpavgvgatmtlamDIrlAStAARFGFVFGRRGIVPEAASSWFLPRL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 173 IGMALAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYrkalDLAREFLPQ-GPVAMRVAK------LAINQGMEVD 245
Cdd:PRK08260 169 VGLQTALEWVYSGRVFDAQEALDGGLVRSVHPPDELLPAAR----ALAREIADNtSPVSVALTRqmmwrmAGADHPMEAH 244

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 564390642 246 LVTGLAIeeacYAQTIStKDRLEGLLAFKEKRPPRYKG 283
Cdd:PRK08260 245 RVDSRAI----YSRGRS-GDGKEGVSSFLEKRPAVFPG 277
PLN02888 PLN02888
enoyl-CoA hydratase
 58-253 3.37e-19

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 84.80  E-value: 3.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  58 LEEENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAKMHSSEVG------ 131
Cdd:PLN02888  13 VPKSRNGIATITINRPKALNALTRPMMVELAAAFKRLDEDDSVKVIILTGSGRA-FCSGVDLTAAEEVFKGDVKdvetdp 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 132 ---------PFVSKIR----------AVINDI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLD 189
Cdd:PLN02888  92 vaqmercrkPIIGAINgfaitagfeiALACDIlvaSRGAKFIDTHAKFGIFPSWGLSQKLSRIIGANRAREVSLTAMPLT 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564390642 190 GQEAKAVGLISHVLEQNQegdaAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIE 253
Cdd:PLN02888 172 AETAERWGLVNHVVEESE----LLKKAREVAEAIIKNNQGMVLRYKSVINDGLKLDLGHALQLE 231
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
 58-255 4.43e-19

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 84.26  E-value: 4.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  58 LEEENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPgIFCAGADLKE--------RAKMHSSE 129
Cdd:PRK06190   7 LVETHDRVRTLTLNRPEARNALSAALRRALFAALAEADADDDVDVVVLTGADP-AFCAGLDLKElggdgsayGAQDALPN 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 130 VGPFVSKIRA-VINDIASSAKMGLVETKLA--------------------IIPGGGGTQRLPRAIGMALAKELIFSARVL 188
Cdd:PRK06190  86 PSPAWPAMRKpVIGAINGAAVTGGLELALAcdiliaserarfadtharvgILPGWGLSVRLPQKVGIGRARRMSLTGDFL 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564390642 189 DGQEAKAVGLISHVLEQNQEGDAayrkALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEA 255
Cdd:PRK06190 166 DAADALRAGLVTEVVPHDELLPR----ARRLAASIAGNNPAAVRALKASYDDGAAAQTGDALALEAE 228
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
57-283 4.68e-19

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 84.34  E-value: 4.68e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  57 HLEEENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLK-ERAKMHSSEVG---- 131
Cdd:PRK07468   7 RIAVDARGVATLTLNRPEKHNALSARMIAELTTAARRLAADAAVRVVVLTGAGKS-FCAGGDLGwMRAQMTADRATriee 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 132 ----------------PFVSKIR----------AVINDIA---SSAKMGLVETKLAIIPGGGGTQRLPRaIGMALAKELI 182
Cdd:PRK07468  86 arrlammlkalndlpkPLIGRIQgqafgggvglISVCDVAiavSGARFGLTETRLGLIPATISPYVVAR-MGEANARRVF 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 183 FSARVLDGQEAKAVGLISHVLEQNQEgDAAYRKALdlaREFLPQGPVAMRVAK-LAINQGMEVDlvtglaieEACYAQTI 261
Cdd:PRK07468 165 MSARLFDAEEAVRLGLLSRVVPAERL-DAAVEAEV---TPYLSCAPGAVAAAKaLVRALGAPID--------EAVIDATI 232

                        250       260
                 ....*....|....*....|....*....
gi 564390642 262 S-------TKDRLEGLLAFKEKRPPRYKG 283
Cdd:PRK07468 233 EaladtweTEEAREGIAAFFDKRAPAWRG 261
PRK11423 PRK11423
methylmalonyl-CoA decarboxylase; Provisional
 65-284 5.06e-19

methylmalonyl-CoA decarboxylase; Provisional


Pssm-ID: 236908 [Multi-domain]  Cd Length: 261  Bit Score: 83.92  E-value: 5.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  65 IVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKkVRTIIIRSEVPG-IFCAGADLKERAKMHSSEVG---PFVSKIRA- 139
Cdd:PRK11423  14 IATITFNNPAKRNALSKVLIDDLMQALSDLNRPE-IRVVILRAPSGSkVWSAGHDIHELPSGGRDPLSyddPLRQILRMi 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 140 ------VINDIASSAKMGLVE-------------TKLAIIPGG-------GGTQRLPRAIGMALAKELIFSARVLDGQEA 193
Cdd:PRK11423  93 qkfpkpVIAMVEGSVWGGAFElimscdliiaastSTFAMTPANlgvpynlSGILNFTNDAGFHIVKEMFFTASPITAQRA 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 194 KAVGLISHVLEQNQEGDAAYrkalDLAREFLPQGPVAMRVAK-----LAINQGMEVDL---VTGLAieeacyAQTISTKD 265
Cdd:PRK11423 173 LAVGILNHVVEVEELEDFTL----QMAHHISEKAPLAIAVIKeqlrvLGEAHPMNPDEferIQGLR------RAVYDSED 242

                        250
                 ....*....|....*....
gi 564390642 266 RLEGLLAFKEKRPPRYKGE 284
Cdd:PRK11423 243 YQEGMNAFLEKRKPVFVGH 261
PRK06210 PRK06210
enoyl-CoA hydratase; Provisional
 59-283 2.25e-18

enoyl-CoA hydratase; Provisional


Pssm-ID: 180472  Cd Length: 272  Bit Score: 82.45  E-value: 2.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  59 EEENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKE------RAKMHSSEVGP 132
Cdd:PRK06210  10 EVADSGVAVITLNRPDRLNAWTPVMEAEVYAAMDRAEADPAVRVIVLTGAGRG-FCAGADMGElqtidpSDGRRDTDVRP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 133 FVSKIR------------------AVIN--------------DI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMAL 177
Cdd:PRK06210  89 FVGNRRpdyqtryhfltalrkpviAAINgacagiglthalmcDVrfaADGAKFTTAFARRGLIAEHGISWILPRLVGHAN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 178 AKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKALDLAREFlpqGPVAMRVAKLAINQGMEVDLVTGLAIEEACY 257
Cdd:PRK06210 169 ALDLLLSARTFYAEEALRLGLVNRVVPPDELMERTLAYAEDLARNV---SPASMAVIKRQLYEDAFQTLAEATARANREM 245

                        250       260
                 ....*....|....*....|....*.
gi 564390642 258 AQTISTKDRLEGLLAFKEKRPPRYKG 283
Cdd:PRK06210 246 HESLQRPDFIEGVASFLEKRPPRFPG 271
PRK06563 PRK06563
crotonase/enoyl-CoA hydratase family protein;
61-283 3.10e-18

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180625 [Multi-domain]  Cd Length: 255  Bit Score: 81.93  E-value: 3.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  61 ENRG-IVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERA--------KMHSSEVG 131
Cdd:PRK06563   4 ERRGhVLLIGLDRPAKRNAFDSAMLDDLALALGEYEADDELRVAVLFAHGEH-FTAGLDLADVApklaaggfPFPEGGID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 132 PF------VSK--IRAV----------------INDIASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARV 187
Cdd:PRK06563  83 PWgtvgrrLSKplVVAVqgycltlgielmlaadIVVAADNTRFAQLEVQRGILPFGGATLRFPQAAGWGNAMRYLLTGDE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 188 LDGQEAKAVGLISHVLEQNQEgdaaYRKALDLAREFLPQGPVAMRV----AKLAINQGMEVdlvtglAIEE--ACYAQTI 261
Cdd:PRK06563 163 FDAQEALRLGLVQEVVPPGEQ----LERAIELAERIARAAPLGVQAtlasARAAVREGEAA------AAAQlpPELRPLF 232

                        250       260
                 ....*....|....*....|..
gi 564390642 262 STKDRLEGLLAFKEKRPPRYKG 283
Cdd:PRK06563 233 TSEDAKEGVQAFLERRPARFKG 254
PRK05995 PRK05995
enoyl-CoA hydratase; Provisional
 57-284 2.36e-17

enoyl-CoA hydratase; Provisional


Pssm-ID: 235664 [Multi-domain]  Cd Length: 262  Bit Score: 79.58  E-value: 2.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  57 HLEEENRGIV-VLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAKMHS-SEVGPFV 134
Cdd:PRK05995   5 TLEIEQRGQVaTVTLNRPDVRNAFNETVIAELTAAFRALDADDSVRAVVLAGAGKA-FCAGADLNWMKKMAGySDDENRA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 135 SKIR----------------AVIN--------------DIA---SSAKMGLVETKLAIIPggggTQRLP---RAIGMALA 178
Cdd:PRK05995  84 DARRladmlraiyrcpkpviARVHgdayaggmglvaacDIAvaaDHAVFCLSEVRLGLIP----ATISPyviRAMGERAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 179 KELIFSARVLDGQEAKAVGLISHVLEQnQEGDAayrKALDLAREFLPQGPVAMRVAKLAINQgmevdlVTGLAIEEACYA 258
Cdd:PRK05995 160 RRYFLTAERFDAAEALRLGLVHEVVPA-EALDA---KVDELLAALVANSPQAVRAGKRLVRD------VAGRPIDAALIA 229

                        250       260       270
                 ....*....|....*....|....*....|...
gi 564390642 259 QTIS-------TKDRLEGLLAFKEKRPPRYKGE 284
Cdd:PRK05995 230 DTASrialiraTEEAREGVAAFLEKRKPAWRGR 262
PRK03580 PRK03580
crotonobetainyl-CoA hydratase;
93-284 7.58e-17

crotonobetainyl-CoA hydratase;


Pssm-ID: 179599 [Multi-domain]  Cd Length: 261  Bit Score: 78.20  E-value: 7.58e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  93 ALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSE----VGPF--VSKIR-------AVINDI--------------- 144
Cdd:PRK03580  40 NFRDDPELRVAIITGAGEKFFSAGWDLKAAAEGEAPDadfgPGGFagLTEIFdldkpviAAVNGYafgggfelalaadfi 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 145 --ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYrkalDLARE 222
Cdd:PRK03580 120 vcADNASFALPEAKLGIVPDSGGVLRLPKRLPPAIANEMVMTGRRMDAEEALRWGIVNRVVPQAELMDRAR----ELAQQ 195

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564390642 223 FLPQGPVAMRVAKLAINQGMEVDLVTGLAI----EEACYAQTISTKDRLEGLLAFKEKRPPRYKGE 284
Cdd:PRK03580 196 LVNSAPLAIAALKEIYRETSEMPVEEAYRYirsgVLKHYPSVLHSEDALEGPRAFAEKRDPVWKGR 261
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
 58-284 1.28e-16

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 77.67  E-value: 1.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  58 LEEENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPgIFCAGADLKE----RAKMHSSEV--- 130
Cdd:PRK08139  14 LREDRDGVATLTLNRPQAFNALSEAMLAALQAALDAIAADPSVRVVVLAAAGK-AFCAGHDLKEmraaRGLAYFRALfar 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 131 -GPFVSKIR-------AVINDIASSAKMGLVET-KLAI-------------------IPGGGgtqrLPRAIGMALAKELI 182
Cdd:PRK08139  93 cSRVMQAIValpqpviARVHGIATAAGCQLVAScDLAVaadtarfavpgvniglfcsTPMVA----LSRNVPRKQAMEML 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 183 FSARVLDGQEAKAVGLISHVLEQNQEGDAAYRkaldLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIS 262
Cdd:PRK08139 169 LTGEFIDAATAREWGLVNRVVPADALDAAVAR----LAAVIAAKSPAAVRIGKEAFYRQAEMPLADAYAYAGDVMAENMM 244

                        250       260
                 ....*....|....*....|..
gi 564390642 263 TKDRLEGLLAFKEKRPPRYKGE 284
Cdd:PRK08139 245 AEDAEEGIDAFLEKRPPEWRGR 266
PRK07511 PRK07511
enoyl-CoA hydratase; Provisional
 67-283 2.00e-16

enoyl-CoA hydratase; Provisional


Pssm-ID: 181009 [Multi-domain]  Cd Length: 260  Bit Score: 76.96  E-value: 2.00e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  67 VLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLK---ERAKMHSSE-------VGPFVSK 136
Cdd:PRK07511  15 VLTLSNPGARNALHPDMYAAGIEALNTAERDPSIRAVVLTGA-GGFFCAGGNLNrllENRAKPPSVqaasidgLHDWIRA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 137 IRA----VINDI--------------------ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDGQE 192
Cdd:PRK07511  94 IRAfpkpVIAAVegaaagagfslalacdllvaARDAKFVMAYVKVGLTPDGGGSWFLARALPRQLATELLLEGKPISAER 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 193 AKAVGLISHVLEQNQEGDAAyrkaLDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGLLA 272
Cdd:PRK07511 174 LHALGVVNRLAEPGQALAEA----LALADQLAAGSPNALARIKSLIADAPEATLAAQLEAERDHFVASLHHADALEGIAA 249

                        250
                 ....*....|.
gi 564390642 273 FKEKRPPRYKG 283
Cdd:PRK07511 250 FLEKRAPDYKR 260
PRK08150 PRK08150
crotonase/enoyl-CoA hydratase family protein;
60-221 2.70e-16

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181254  Cd Length: 255  Bit Score: 76.60  E-value: 2.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  60 EENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDkkVRTIIIRSEVPGiFCAGADLKERAKMHSSEVG-------- 131
Cdd:PRK08150   7 ELDGGVATIGLNRPAKRNALNDGLIAALRAAFARLPEG--VRAVVLHGEGDH-FCAGLDLSELRERDAGEGMhhsrrwhr 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 132 ----------PFVSKIR-AVIN---DIASSAKM---------GLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVL 188
Cdd:PRK08150  84 vfdkiqygrvPVIAALHgAVVGgglELASAAHIrvadestyfALPEGQRGIFVGGGGSVRVPRLIGVARMTDMMLTGRVY 163

                        170       180       190
                 ....*....|....*....|....*....|...
gi 564390642 189 DGQEAKAVGLISHVLEQNQegdaAYRKALDLAR 221
Cdd:PRK08150 164 DAQEGERLGLAQYLVPAGE----ALDKAMELAR 192
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
53-212 1.89e-15

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 76.05  E-value: 1.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  53 LRVRHLEEenrGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPgIFCAGADLKERA---KMHSSE 129
Cdd:PRK11730   8 LQVDWLED---GIAELVFDAPGSVNKLDRATLASLGEALDALEAQSDLKGLLLTSAKD-AFIVGADITEFLslfAAPEEE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 130 VGPFVSKIRAVINDI-------------------------------ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALA 178
Cdd:PRK11730  84 LSQWLHFANSIFNRLedlpvptvaaingyalgggcecvlatdyrvaSPDARIGLPETKLGIMPGFGGTVRLPRLIGADNA 163

                        170       180       190
                 ....*....|....*....|....*....|....
gi 564390642 179 KELIFSARVLDGQEAKAVGLISHVLEQNQEGDAA 212
Cdd:PRK11730 164 LEWIAAGKDVRAEDALKVGAVDAVVAPEKLQEAA 197
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
 64-284 2.13e-15

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 74.18  E-value: 2.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  64 GIVVLGINRAYGKNSLSKNLLKMLSKAVDALKsDKKVRTIIIRSEVPGiFCAGADLKER---AKMHSSEVG--------P 132
Cdd:PRK08140  13 GVATLTLNRPDKLNSFTREMHRELREALDQVE-DDGARALLLTGAGRG-FCAGQDLADRdvtPGGAMPDLGesietfynP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 133 FVSKIRA----VI---N--------------DI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVL 188
Cdd:PRK08140  91 LVRRLRAlplpVIaavNgvaagaganlalacDIvlaARSASFIQAFVKIGLVPDSGGTWFLPRLVGMARALGLALLGEKL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 189 DGQEAKAVGLISHVLEqnqegDAAYR-KALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRL 267
Cdd:PRK08140 171 SAEQAEQWGLIWRVVD-----DAALAdEAQQLAAHLATQPTRGLALIKQAMNASATNTLDAQLDLERDLQREAGRSADYA 245

                        250
                 ....*....|....*..
gi 564390642 268 EGLLAFKEKRPPRYKGE 284
Cdd:PRK08140 246 EGVSAFLEKRAPRFTGR 262
PRK06144 PRK06144
enoyl-CoA hydratase; Provisional
 49-283 1.55e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 180424 [Multi-domain]  Cd Length: 262  Bit Score: 68.87  E-value: 1.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  49 TEDELrvrhLEEENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSS 128
Cdd:PRK06144   6 STDEL----LLEVRGGIARITFNRPAARNAMTWAMYEGLAEICEAIAADPSIRAVVLRGAGDKAFVAGTDIAQFRAFSTA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 129 EVG-PFVSKIRAVIndiassakmGLVET----KLAIIPG---GGGT---------------------------------- 166
Cdd:PRK06144  82 EDAvAYERRIDRVL---------GALEQlrvpTIAAIAGacvGGGAaiaaacdlriatpsarfgfpiartlgnclsmsnl 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 167 QRLPRAIGMALAKELIFSARVLDGQEAKAVGLISHVLEQnqegDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDL 246
Cdd:PRK06144 153 ARLVALLGAARVKDMLFTARLLEAEEALAAGLVNEVVED----AALDARADALAELLAAHAPLTLRATKEALRRLRREGL 228

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 564390642 247 VTGLAIEEACYaqtiSTKDRLEGLLAFKEKRPPRYKG 283
Cdd:PRK06144 229 PDGDDLIRMCY----MSEDFREGVEAFLEKRPPKWKG 261
PLN02664 PLN02664
enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase
 62-281 1.81e-13

enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase


Pssm-ID: 178269 [Multi-domain]  Cd Length: 275  Bit Score: 68.78  E-value: 1.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  62 NRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVrTIIIRSEVPGIFCAGADLK------------------ER- 122
Cdd:PLN02664  15 NSSVFHLNLNRPSQRNALSLDFFTEFPKALSSLDQNPNV-SVIILSGAGDHFCSGIDLKtlnsiseqsssgdrgrsgERl 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 123 ----------------------AKMHSSEVGPFVSKIRAV-INDIASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAK 179
Cdd:PLN02664  94 rrkikflqdaitaieqcrkpviAAIHGACIGGGVDIVTACdIRYCSEDAFFSVKEVDLAITADLGTLQRLPSIVGYGNAM 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 180 ELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKaldLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQ 259
Cdd:PLN02664 174 ELALTGRRFSGSEAKELGLVSRVFGSKEDLDEGVRL---IAEGIAAKSPLAVTGTKAVLLRSRELSVEQGLDYVATWNSA 250

                        250       260
                 ....*....|....*....|..
gi 564390642 260 TISTKDRLEGLLAFKEKRPPRY 281
Cdd:PLN02664 251 MLVSDDLNEAVSAQIQKRKPVF 272
PRK06495 PRK06495
enoyl-CoA hydratase/isomerase family protein;
77-283 2.36e-13

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 168580 [Multi-domain]  Cd Length: 257  Bit Score: 68.18  E-value: 2.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  77 NSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMHSSEvGPFVSKIR-----------------A 139
Cdd:PRK06495  25 NALSRELRDELIAVFDEISERPDVRVVVLTGA-GKVFCAGADLKGRPDVIKGP-GDLRAHNRrtrecfhairecakpviA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 140 VINDIASSAKMGLV---------ETKLAIIPG-----GGGTQRLPRAIGMALAKELIFSARVLDGQEAKAVGLISHVLEq 205
Cdd:PRK06495 103 AVNGPALGAGLGLVascdiivasENAVFGLPEidvglAGGGKHAMRLFGHSLTRRMMLTGYRVPAAELYRRGVIEACLP- 181

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564390642 206 nqeGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGLLAFKEKRPPRYKG 283
Cdd:PRK06495 182 ---PEELMPEAMEIAREIASKSPLATRLAKDALNTIENMSLRDGYRYEQDITAKLAKTEDAKEAQRAFLEKRPPVFKG 256
PRK05869 PRK05869
enoyl-CoA hydratase; Validated
 60-239 2.57e-13

enoyl-CoA hydratase; Validated


Pssm-ID: 235632 [Multi-domain]  Cd Length: 222  Bit Score: 67.56  E-value: 2.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  60 EENRGIVVLGINRAyGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMHSSEVGPFVSKIRA 139
Cdd:PRK05869  13 SQDAGLATLLLSRP-PTNALTRQVYREIVAAANELGRRDDVAAVILYGG-HEIFSAGDDMPELRTLSAQEADTAARVRQQ 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 140 VINDIAS-------------------------------SAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVL 188
Cdd:PRK05869  91 AVDAVAAipkptvaaitgyalgagltlalaadwrvsgdNVKFGATEILAGLAPSGDGMARLTRAAGPSRAKELVFSGRFF 170

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564390642 189 DGQEAKAVGLISHVLEQnqegDAAYRKALDLAREFLPQGPVAMRVAKLAIN 239
Cdd:PRK05869 171 DAEEALALGLIDEMVAP----DDVYDAAAAWARRFLDGPPHALAAAKAGIS 217
PRK07659 PRK07659
enoyl-CoA hydratase; Provisional
 60-284 2.92e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 236073 [Multi-domain]  Cd Length: 260  Bit Score: 68.14  E-value: 2.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  60 EENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALK-SDKKVrtIIIRSEVPGiFCAGADLKERAKMHSSEvgpfvsKIR 138
Cdd:PRK07659  11 KYEGRVATIMLNRPEALNALDEPMLKELLQALKEVAeSSAHI--VVLRGNGRG-FSAGGDIKMMLSSNDES------KFD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 139 AVINDI-------------------ASSAKMGL------------VETKLA-------IIPGGGGTQRLPRAIGMALAKE 180
Cdd:PRK07659  82 GVMNTIseivvtlytmpkltisaihGPAAGLGLsialtadyviadISAKLAmnfigigLIPDGGGHFFLQKRVGENKAKQ 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 181 LIFSARVLDGQEAKAVGLISHVLEqnQEGDAAYRKALDlarEFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQT 260
Cdd:PRK07659 162 IIWEGKKLSATEALDLGLIDEVIG--GDFQTAAKQKIS---EWLQKPLKAMIETKQIYCELNRSQLEQVLQLEKRAQYAM 236

                        250       260
                 ....*....|....*....|....
gi 564390642 261 ISTKDRLEGLLAFKEKRPPRYKGE 284
Cdd:PRK07659 237 RQTADHKEGIRAFLEKRLPVFKGE 260
PRK05981 PRK05981
enoyl-CoA hydratase/isomerase;
60-283 1.68e-12

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235661  Cd Length: 266  Bit Score: 65.91  E-value: 1.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  60 EENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDK-KVRTIIIRSEVPGiFCAGADLKER---AKMHSSEVG---- 131
Cdd:PRK05981   9 DFDGGVAILTLDHPEVMNAVSIDMLGGLAEALDAIEDGKaEVRCLVLTGAGRG-FCTGANLQGRgsgGRESDSGGDagaa 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 132 ------PFVSKIR---------------------AVINDI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKEL 181
Cdd:PRK05981  88 letayhPFLRRLRnlpcpivtavngpaagvgmsfALMGDLilcARSAYFLQAFRRIGLVPDGGSTWLLPRLVGKARAMEL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 182 IFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKALDLAReflpqGP-VAMRVAKLAINQGMEVDLVTGLAIEeaCYAQT 260
Cdd:PRK05981 168 SLLGEKLPAETALQWGLVNRVVDDAELMAEAMKLAHELAN-----GPtVALGLIRKLYWDSPENDFEEQLNLE--REAQR 240

                        250       260
                 ....*....|....*....|....*
gi 564390642 261 I--STKDRLEGLLAFKEKRPPRYKG 283
Cdd:PRK05981 241 IagKTEDFKEGVGAFLQKRPAQFKG 265
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 57-262 2.41e-12

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 66.78  E-value: 2.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642   57 HLEEENRG-IVVLGINRAYGK-NSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERA----------- 123
Cdd:TIGR02441  14 HRHYEVKGdVAVVKIDSPNSKvNTLSKELFAEFKEVMNELWTNEAIKSAVLISGKPGSFVAGADIQMIAacktaqevtql 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  124 ---------KMHSSEvGPFVSKI-----------------RAVINDiaSSAKMGLVETKLAIIPGGGGTQRLPRAIGMAL 177
Cdd:TIGR02441  94 sqegqemfeRIEKSQ-KPIVAAIsgsclggglelalachyRIATKD--RKTLLGLPEVMLGLLPGAGGTQRLPKLTGVPA 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  178 AKELIFSARVLDGQEAKAVGLISHVLEQNQEGdaaYRKALDLAREFLPQgpVAMRVAKLAINQGMEVDLVTGLAIEEACY 257
Cdd:TIGR02441 171 ALDMMLTGKKIRADRAKKMGIVDQLVDPLGPG---LKPAEENTIEYLEE--VAVKFAQGLANGKLSINRDKGLVHKITQY 245


                  ....*
gi 564390642  258 AQTIS 262
Cdd:TIGR02441 246 VMTNP 250
PRK06072 PRK06072
enoyl-CoA hydratase; Provisional
 60-284 3.26e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 168377 [Multi-domain]  Cd Length: 248  Bit Score: 64.80  E-value: 3.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  60 EENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAKMHSSEVG----PFVS 135
Cdd:PRK06072   5 ESREGYAIVTMSRPDKLNALNLEMRNEFISKLKQINADPKIRVVIVTGEGRA-FCVGADLSEFAPDFAIDLRetfyPIIR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 136 KIR-------AVINDIASSAKMGLV----------ETK-------LAIIPGGGGTQRLPRAIGMALAKELI----FSArv 187
Cdd:PRK06072  84 EIRfsdkiyiSAINGVTAGACIGIAlstdfkfasrDVKfvtafqrLGLASDTGVAYFLLKLTGQRFYEILVlggeFTA-- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 188 ldgQEAKAVGLISHVleqnqegDAAYRKALDLAREFLpQGPVAMRVA-KLAINQGMEVDLVTGLAIEEACYAQTISTKDR 266
Cdd:PRK06072 162 ---EEAERWGLLKIS-------EDPLSDAEEMANRIS-NGPFQSYIAaKRMINLVLYNDLEEFLEYESAIQGYLGKTEDF 230

                        250
                 ....*....|....*...
gi 564390642 267 LEGLLAFKEKRPPRYKGE 284
Cdd:PRK06072 231 KEGISSFKEKREPKFKGI 248
PRK07327 PRK07327
enoyl-CoA hydratase/isomerase family protein;
64-283 7.68e-11

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 235991  Cd Length: 268  Bit Score: 61.19  E-value: 7.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  64 GIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAKMHSSEVG------------ 131
Cdd:PRK07327  21 GVLEIVLNGPGALNAADARMHRELADIWRDVDRDPDVRVVLIRGEGKA-FSAGGDLALVEEMADDFEVrarvwreardlv 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 132 --------PFVSKIR----------AVINDI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDG 190
Cdd:PRK07327 100 ynvincdkPIVSAIHgpavgaglvaALLADIsiaAKDARIIDGHTRLGVAAGDHAAIVWPLLCGMAKAKYYLLLCEPVSG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 191 QEAKAVGLISHVLEQnqegDAAYRKALDLAREfLPQG-PVAMRVAKLAINQGMEV---DLVTGLAIEEACYAqtisTKDR 266
Cdd:PRK07327 180 EEAERIGLVSLAVDD----DELLPKALEVAER-LAAGsQTAIRWTKYALNNWLRMagpTFDTSLALEFMGFS----GPDV 250

                        250
                 ....*....|....*..
gi 564390642 267 LEGLLAFKEKRPPRYKG 283
Cdd:PRK07327 251 REGLASLREKRAPDFPG 267
PRK08258 PRK08258
enoyl-CoA hydratase family protein;
52-283 9.09e-11

enoyl-CoA hydratase family protein;


Pssm-ID: 181329  Cd Length: 277  Bit Score: 61.14  E-value: 9.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  52 ELRVRHLE-EENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKE----RAKMH 126
Cdd:PRK08258  13 GYEARHFLwEVDDGVATITLNRPERKNPLTFESYAELRDLFRELVYADDVKAVVLTGAGGN-FCSGGDVHEiigpLTKMD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 127 SSEV-------GPFVSKIR-------AVINDIASSA----------KMGLVETKLAII------PGG--GGTQRLPRAIG 174
Cdd:PRK08258  92 MPELlaftrmtGDLVKAMRacpqpiiAAVDGVCAGAgailamasdlRLGTPSAKTAFLftrvglAGAdmGACALLPRIIG 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 175 MALAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKALDLAReflpqGPV-AMRVAKLAINQgmEVDLVTGLAIE 253
Cdd:PRK08258 172 QGRASELLYTGRSMSAEEGERWGFFNRLVEPEELLAEAQALARRLAA-----GPTfAHGMTKTMLHQ--EWDMGLEEAIE 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 564390642 254 EACYAQTI--STKDRLEGLLAFKEKRPPRYKG 283
Cdd:PRK08258 245 AEAQAQAIcmQTEDFRRAYEAFVAKRKPVFEG 276
PLN02921 PLN02921
naphthoate synthase
 64-281 1.00e-09

naphthoate synthase


Pssm-ID: 178509 [Multi-domain]  Cd Length: 327  Bit Score: 58.26  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  64 GIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAK---MHSSEVG--------- 131
Cdd:PLN02921  76 GIAKITINRPERRNAFRPRTVKELQRAFNDARDDSSVGVIILTGKGTKAFCSGGDQAVRGKdgyVGPDDAGrlnvldlqi 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 132 -------PFVSKIR--AV--------INDI---ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDGQ 191
Cdd:PLN02921 156 qirrlpkPVIAMVAgyAVggghilhmVCDLtiaADNAVFGQTGPKVGSFDAGYGSSIMARLVGQKKAREMWFLARFYTAS 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 192 EAKAVGLISHVLEQNQ-EGDAAyrkalDLAREFLPQGPVAMRVAKLAINQGMevDLVTGLAiEEACYAQTI--STKDRLE 268
Cdd:PLN02921 236 EALKMGLVNTVVPLDElEGETV-----KWCREILRNSPTAIRVLKSALNAAD--DGHAGLQ-ELGGNATLLfyGSEEGNE 307

                        250
                 ....*....|...
gi 564390642 269 GLLAFKEKRPPRY 281
Cdd:PLN02921 308 GRTAYLEGRAPDF 320
PRK07396 PRK07396
dihydroxynaphthoic acid synthetase; Validated
 64-282 1.26e-09

dihydroxynaphthoic acid synthetase; Validated


Pssm-ID: 180958 [Multi-domain]  Cd Length: 273  Bit Score: 57.60  E-value: 1.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  64 GIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKER--------AKMHSSEVGPFVS 135
Cdd:PRK07396  22 GIAKITINRPEVRNAFRPKTVKEMIDAFADARDDDNIGVIILTGAGDKAFCSGGDQKVRgyggyvddDGVPRLNVLDLQR 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 136 KIRA---------------------VIND--IAS-SAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDGQ 191
Cdd:PRK07396 102 LIRTcpkpviamvagyaiggghvlhLVCDltIAAdNAIFGQTGPKVGSFDGGYGASYLARIVGQKKAREIWFLCRQYDAQ 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 192 EAKAVGLISHV--LEQNQEgdaayrKALDLAREFLPQGPVAMRVAKLAINQgmEVDLVTGLAiEEACYAQTI--STKDRL 267
Cdd:PRK07396 182 EALDMGLVNTVvpLADLEK------ETVRWCREMLQNSPMALRCLKAALNA--DCDGQAGLQ-ELAGNATMLfyMTEEAQ 252

                        250
                 ....*....|....*
gi 564390642 268 EGLLAFKEKRPPRYK 282
Cdd:PRK07396 253 EGRNAFNEKRQPDFS 267
PRK07854 PRK07854
enoyl-CoA hydratase; Provisional
 61-283 2.03e-09

enoyl-CoA hydratase; Provisional


Pssm-ID: 236115 [Multi-domain]  Cd Length: 243  Bit Score: 56.57  E-value: 2.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  61 ENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALkSDKKVRTIIIRSEVPgIFCAGADL-----------KERAKMHSSE 129
Cdd:PRK07854   6 RDGQVLTIELQRPERRNALNAELCEELREAVRKA-VDESARAIVLTGQGT-VFCAGADLsgdvyaddfpdALIEMLHAID 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 130 VGPFvskirAVINDI--------------------ASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLD 189
Cdd:PRK07854  84 AAPV-----PVIAAIngpaigaglqlamacdlrvvAPEAYFQFPVAKYGIALDNWTIRRLSSLVGGGRARAMLLGAEKLT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 190 GQEAKAVGLIshvleqNQEGDAAyrKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTglAIEEACYAQTISTKDRLEG 269
Cdd:PRK07854 159 AEQALATGMA------NRIGTLA--DAQAWAAEIAGLAPLALQHAKRVLNDDGAIEEAW--PAHKELFDKAWASQDAIEA 228

                        250
                 ....*....|....
gi 564390642 270 LLAFKEKRPPRYKG 283
Cdd:PRK07854 229 QVARIEKRPPKFQG 242
PRK06143 PRK06143
enoyl-CoA hydratase; Provisional
 63-235 2.91e-09

enoyl-CoA hydratase; Provisional


Pssm-ID: 180423  Cd Length: 256  Bit Score: 56.20  E-value: 2.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  63 RGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGPFVSKIRAVIN 142
Cdd:PRK06143  15 RGVATLTIRNAGSLNILGTPVILALTQALRWLAADPDVRVLVLRGAGEKAFIGGADIKEMATLDQASAEAFISRLRDLCD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 143 DI-------------------------------ASSAKMGLVETKLAIiPGGGGTQRLPRAIGMALAKELIFSARVLDGQ 191
Cdd:PRK06143  95 AVrhfpvpviaripgwclggglelaaacdlriaAHDAQFGMPEVRVGI-PSVIHAALLPRLIGWARTRWLLLTGETIDAA 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 564390642 192 EAKAVGLISHVLEqNQEGDAAYRKaldLAREFLPQGPVAMRVAK 235
Cdd:PRK06143 174 QALAWGLVDRVVP-LAELDAAVER---LAASLAGCGPQALRQQK 213
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
94-217 6.28e-09

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 56.44  E-value: 6.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  94 LKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVG-------------------PFVSKI----------------- 137
Cdd:PRK11154  46 LREDKELKGVVFISGKPDNFIAGADINMLAACKTAQEAealarqgqqlfaeiealpiPVVAAIhgaclggglelalachy 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 138 RAVINDiaSSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKAL 217
Cdd:PRK11154 126 RVCTDD--PKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALDMILTGKQLRAKQALKLGLVDDVVPHSILLEVAVELAK 203
PRK08259 PRK08259
crotonase/enoyl-CoA hydratase family protein;
111-253 1.18e-08

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236205  Cd Length: 254  Bit Score: 54.52  E-value: 1.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 111 GIFCAGADLK-----ERAKMHSSEVGPF------VSKirAVINDIASSAKMGLVEtkLAI-------------------- 159
Cdd:PRK08259  58 GTFCAGADLKavgtgRGNRLHPSGDGPMgpsrmrLSK--PVIAAVSGYAVAGGLE--LALwcdlrvaeedavfgvfcrrw 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 160 -IPG-GGGTQRLPRAIGMALAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKALDLARefLPQgpVAMRVAKLA 237
Cdd:PRK08259 134 gVPLiDGGTVRLPRLIGHSRAMDLILTGRPVDADEALAIGLANRVVPKGQARAAAEELAAELAA--FPQ--TCLRADRLS 209

                        170
                 ....*....|....*.
gi 564390642 238 INQGMEVDLVTGLAIE 253
Cdd:PRK08259 210 ALEQWGLPEEAALANE 225
PRK07110 PRK07110
polyketide biosynthesis enoyl-CoA hydratase; Validated
 52-221 2.70e-08

polyketide biosynthesis enoyl-CoA hydratase; Validated


Pssm-ID: 235936  Cd Length: 249  Bit Score: 53.43  E-value: 2.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  52 ELRVRHLEEENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAGADLKER--------- 122
Cdd:PRK07110   2 MMKVVELREVEEGIAQVTMQDRVNKNAFSDELCDQLHEAFDTIAQDPRYKVVILTG-YPNYFATGGTQEGLlslqtgkgt 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 123 ------------------AKMHSSEVGP-FVSKIRAvinDI----------ASSAKMGLVetklaiiPGGGGTQRLPRAI 173
Cdd:PRK07110  81 fteanlyslalncpipviAAMQGHAIGGgLVLGLYA---DIvvlsresvytANFMKYGFT-------PGMGATAILPEKL 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 564390642 174 GMALAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKALDLAR 221
Cdd:PRK07110 151 GLALGQEMLLTARYYRGAELKKRGVPFPVLPRAEVLEKALELARSLAE 198
PRK07827 PRK07827
enoyl-CoA hydratase family protein;
60-281 3.58e-08

enoyl-CoA hydratase family protein;


Pssm-ID: 236109 [Multi-domain]  Cd Length: 260  Bit Score: 53.15  E-value: 3.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  60 EENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIrSEVPGIFCAGADLKERAKMHSSEVGPFVSKIRA 139
Cdd:PRK07827  11 AVDGGVATLTLDSPHNRNALSARLVAQLHDGLRAAAADPAVRAVVL-THTGGTFCAGADLSEAGGGGGDPYDAAVARARE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 140 VIN---DIASSAK--------------MGLV-----------------ETKLAIIPGGGGTQRLPRAIGMALAKELIFSA 185
Cdd:PRK07827  90 MTAllrAIVELPKpviaaidghvraggFGLVgacdivvagpestfaltEARIGVAPAIISLTLLPRLSPRAAARYYLTGE 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 186 RvLDGQEAKAVGLIShvlEQNQEGDAAYRKALDLAREFLPQGPVAM-RVAKLAINQGMEVDLVTgLAIEEAcyaQTISTK 264
Cdd:PRK07827 170 K-FGAAEAARIGLVT---AAADDVDAAVAALLADLRRGSPQGLAESkALTTAAVLAGFDRDAEE-LTEESA---RLFVSD 241

                        250
                 ....*....|....*..
gi 564390642 265 DRLEGLLAFKEKRPPRY 281
Cdd:PRK07827 242 EAREGMTAFLQKRPPRW 258
PRK08788 PRK08788
enoyl-CoA hydratase; Validated
 52-235 9.45e-08

enoyl-CoA hydratase; Validated


Pssm-ID: 236338  Cd Length: 287  Bit Score: 52.22  E-value: 9.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  52 ELRVRhlEEENRGiVVLGINRAYGKNSLSKNLL---KMLSKAVDALKSDKK--VRTIIIRSEVPGIFCAGADL------- 119
Cdd:PRK08788  16 QLRVY--YEEERN-VMWMYMRAQPRPCFNLELLddiMNLQRAIRQRLDDSGlpVDFWVLASDVPGVFNLGGDLalfaeli 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 120 --KERAKM-----------HSSEVG---PFVSkIRAVIND---------------IA-SSAKMGLVETKLAIIPGGGGTQ 167
Cdd:PRK08788  93 raGDRDALlayaracvdgvHAFHRGfgaGAIS-IALVQGDalgggfeaalshhtiIAeRGAKMGFPEILFNLFPGMGAYS 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564390642 168 RLPRAIGMALAKELIFSARVLDGQEAKAVGLISHVLEQNQeGDAAYRKALDLAREfLPQGPVAMRVAK 235
Cdd:PRK08788 172 FLARRVGPKLAEELILSGKLYTAEELHDMGLVDVLVEDGQ-GEAAVRTFIRKSKR-KLNGWRAMLRAR 237
PRK05674 PRK05674
gamma-carboxygeranoyl-CoA hydratase; Validated
 58-284 7.95e-07

gamma-carboxygeranoyl-CoA hydratase; Validated


Pssm-ID: 168168  Cd Length: 265  Bit Score: 49.42  E-value: 7.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  58 LEEENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADL---KERAKMH-------S 127
Cdd:PRK05674   9 LIRDPRGFATLWLSRADKNNAFNAQMIRELILALDQVQSDASLRFLLLRGRGRH-FSAGADLawmQQSADLDyntnlddA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 128 SEVGPFVSKIR-------AVINDIASSAKMGLV-----------------ETKLAIIPGGGGTqRLPRAIGMALAKELIF 183
Cdd:PRK05674  88 RELAELMYNLYrlkiptlAVVQGAAFGGALGLIsccdmaigaddaqfclsEVRIGLAPAVISP-FVVKAIGERAARRYAL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 184 SARVLDGQEAKAVGLISHVLEQnQEGDAAYRKALDlarEFLPQGPVAMRVAKLAINQGMEVDLVTGL-AIEEACYAQTIS 262
Cdd:PRK05674 167 TAERFDGRRARELGLLAESYPA-AELEAQVEAWIA---NLLLNSPQALRASKDLLREVGDGELSPALrRYCENAIARIRV 242

                        250       260
                 ....*....|....*....|..
gi 564390642 263 TKDRLEGLLAFKEKRPPRYKGE 284
Cdd:PRK05674 243 SAEGQEGLRAFLEKRTPAWQTD 264
PRK07938 PRK07938
enoyl-CoA hydratase family protein;
57-239 9.42e-07

enoyl-CoA hydratase family protein;


Pssm-ID: 181174  Cd Length: 249  Bit Score: 48.81  E-value: 9.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  57 HLEEENRGIVVLGINRAyGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKE--RAKMHSSEVG--- 131
Cdd:PRK07938   4 TSTTPEPGIAEVTVDYP-PVNALPSAGWFALADAITAAGADPDTRVVVLRAEGRG-FNAGVDIKElqATPGFTALIDanr 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 132 --------------PFVskirAVINDIASSAKMGLVETKLAIIPG---------------GGGTQrLPRAIGMALAKELI 182
Cdd:PRK07938  82 gcfaafravyecavPVI----AAVHGFCLGGGIGLVGNADVIVASddatfglpevdrgalGAATH-LQRLVPQHLMRALF 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564390642 183 FSARVLDGQEAKAVGLISHVLEQNQEGDAayrkALDLAREFLPQGPVAMRVAKLAIN 239
Cdd:PRK07938 157 FTAATITAAELHHFGSVEEVVPRDQLDEA----ALEVARKIAAKDTRVIRAAKEALN 209
PRK08321 PRK08321
1,4-dihydroxy-2-naphthoyl-CoA synthase;
56-282 1.16e-06

1,4-dihydroxy-2-naphthoyl-CoA synthase;


Pssm-ID: 181386  Cd Length: 302  Bit Score: 48.87  E-value: 1.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  56 RHLEEenrGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIR----SEVPGI--FCAGADLKERAK----- 124
Cdd:PRK08321  29 RAVDQ---GTVRIAFDRPEVRNAFRPHTVDELYRALDHARMSPDVGCVLLTgngpSPKDGGwaFCSGGDQRIRGRdgyqy 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 125 ----------------MHSSEVGP---FVSK-IRAVIN----------------DIASS--AKMGLVETKLAIIPGGGGT 166
Cdd:PRK08321 106 aegdeadtvdparagrLHILEVQRlirFMPKvVIAVVPgwaaggghslhvvcdlTLASRehARFKQTDADVGSFDGGYGS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 167 QRLPRAIGMALAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAayrkALDLAREFLPQGPVAMRVAKLAINqgMEVD- 245
Cdd:PRK08321 186 AYLARQVGQKFAREIFFLGRTYSAEEAHDMGAVNAVVPHAELETE----ALEWAREINGKSPTAMRMLKYAFN--LTDDg 259

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 564390642 246 -----LVTGLAIEEAcYAqtisTKDRLEGLLAFKEKRPPRYK 282
Cdd:PRK08321 260 lvgqqLFAGEATRLA-YM----TDEAQEGRDAFLEKRDPDWS 296
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
 49-272 5.68e-06

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 47.12  E-value: 5.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  49 TEDELRVrhlEEENR-GIVVLgiNRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLK---ERAK 124
Cdd:PRK05617   1 TEDEVLA---EVEGGvGVITL--NRPKALNALSLEMIRAIDAALDAWEDDDAVAAVVIEGAGERGFCAGGDIRalyEAAR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 125 MHSSEVG-------------------PFVskirAVINDI-----------AS------SAKMGLVETKLAIIPGGGGTQR 168
Cdd:PRK05617  76 AGDPLAAdrffreeyrlnaliarypkPYI----ALMDGIvmgggvgisahGShrivteRTKMAMPETGIGFFPDVGGTYF 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 169 LPRAIGmALAKELIFSARVLDGQEAKAVGLISHVLEQNQEgdAAYRKALDLAREFLPQGPVAMRVAKLAINQGmEVDLVT 248
Cdd:PRK05617 152 LSRAPG-ALGTYLALTGARISAADALYAGLADHFVPSADL--PALLDALISLRWDSGADVVDAALAAFATPAP-ASELAA 227

                        250       260
                 ....*....|....*....|....
gi 564390642 249 GLAIEEACYAQtistkDRLEGLLA 272
Cdd:PRK05617 228 QRAWIDECFAG-----DTVEDIIA 246
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
 64-204 1.19e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 45.49  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  64 GIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAKMHSSEVGPFVSKIR----- 138
Cdd:PRK05870  12 GVALITVNDPDRRNAVTAEMSAQLRAAVAAAEADPDVHALVVTGAGKA-FCAGADLTALGAAPGRPAEDGLRRIYdgfla 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 139 ---------AVINDIASSAKMGLVE-----------------TKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDGQE 192
Cdd:PRK05870  91 vascplptiAAVNGAAVGAGLNLALaadvriagpkalfdarfQKLGLHPGGGATWMLQRAVGPQVARAALLFGMRFDAEA 170

                        170
                 ....*....|..
gi 564390642 193 AKAVGLISHVLE 204
Cdd:PRK05870 171 AVRHGLALMVAD 182
PRK08290 PRK08290
enoyl-CoA hydratase; Provisional
 170-244 1.66e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 236220 [Multi-domain]  Cd Length: 288  Bit Score: 45.34  E-value: 1.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 170 PRAIGMALAKELIFSARVLDGQEAKAVGLISHV-----LEQnqegdaayrKALDLAREFLPQGPVAMRVAKLAINQGMEV 244
Cdd:PRK08290 169 PWELGPRKAKELLFTGDRLTADEAHRLGMVNRVvprdeLEA---------ETLELARRIAAMPPFGLRLTKRAVNQTLDA 239
PRK05864 PRK05864
enoyl-CoA hydratase; Provisional
 64-281 5.93e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 168278 [Multi-domain]  Cd Length: 276  Bit Score: 43.67  E-value: 5.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  64 GIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERA-------------------- 123
Cdd:PRK05864  19 EIALITLNRPERMNSMAFDVMVPLKEALAEVSYDNSVRVVVLTGAGRG-FSSGADHKSAGvvphvegltrptyalrsmel 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 124 ---------KMHSSEV----GPFV---------SKIRAVINDI---ASSAKMGLVETKLaiipggGGTQRLPRAIGMALA 178
Cdd:PRK05864  98 lddvilalrRLHQPVIaavnGPAIggglclalaADIRVASSSAyfrAAGINNGLTASEL------GLSYLLPRAIGSSRA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 179 KELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPqgpvAMRVAKLAINQGMEVDLVTGLAIEEACYA 258
Cdd:PRK05864 172 FEIMLTGRDVDAEEAERIGLVSRQVPDEQLLDTCYAIAARMAGFSRP----GIELTKRTLWSGLDAASLEAHMQAEGLGQ 247

                        250       260
                 ....*....|....*....|....*
gi 564390642 259 QTIS--TKDRLEGLLAFKEKRPPRY 281
Cdd:PRK05864 248 LFVRllTANFEEAVAARAEKRPPVF 272
PRK06023 PRK06023
crotonase/enoyl-CoA hydratase family protein;
64-273 7.63e-05

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 168351  Cd Length: 251  Bit Score: 43.24  E-value: 7.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  64 GIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAGADLKE--RAKMHSSEVG---------- 131
Cdd:PRK06023  15 GVQVIRFNRPEKKNAITRAMYATMAKALKAADADDAIRAHVFLG-TEGCFSAGNDMQDflAAAMGGTSFGseildflial 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 132 -----PFVSK-------IRAVIN---DIASSAKMGLVET---KLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDGQEA 193
Cdd:PRK06023  94 aeaekPIVSGvdglaigIGTTIHlhcDLTFASPRSLFRTpfvDLALVPEAGSSLLAPRLMGHQRAFALLALGEGFSAEAA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 194 KAVGLISHVLEQnqegDAAYRKALDLAREFLPQGPVAMRVAKlAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGLLAF 273
Cdd:PRK06023 174 QEAGLIWKIVDE----EAVEAETLKAAEELAAKPPQALQIAR-DLMRGPREDILARIDEEAKHFAARLKSAEARAAFEAF 248
PRK09120 PRK09120
p-hydroxycinnamoyl CoA hydratase/lyase; Validated
 64-246 7.76e-05

p-hydroxycinnamoyl CoA hydratase/lyase; Validated


Pssm-ID: 236383  Cd Length: 275  Bit Score: 43.07  E-value: 7.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  64 GIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAKmhSSEVGP--FVSKIR--- 138
Cdd:PRK09120  17 GIAWVTLNRPEKRNAMSPTLNREMIDVLDALEFDDDAGVLVLTGAGDA-WSAGMDLKEYFR--ETDAQPeiLQERIRrea 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 139 ---------------AVIN--------------DIA---SSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSAR 186
Cdd:PRK09120  94 ygwwrrlrwyqkptiAMVNgwcfgggfsplvacDLAiaaDEAQFGLSEINWGIPPGGGVSKAMADTVGHRDALYYIMTGE 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 187 VLDGQEAKAVGLISHVLEQNQEgDAAYRKaldLAREFLPQGPVAMRVAKLAINQGMEVDL 246
Cdd:PRK09120 174 TFTGRKAAEMGLVNESVPLAQL-RARTRE---LAAKLLEKNPVVLRAAKDGFKRVRELTW 229
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 77-204 1.02e-04

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 43.23  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642   77 NSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKM----HSSEVGPFVSKIRAVINDIASSAK--- 149
Cdd:pfam16113  13 NALNLEMVRALLAALKAWEDDPAVKLVVLKGAGERAFCAGGDVRALYEAakagGGEAGRDFFREEYRLNYLIATYPKpyv 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  150 -----------MGLV-----------------ETKLAIIPGGGGT---QRLPRAIGMALAkeliFSARVLDGQEAKAVGL 198
Cdd:pfam16113  93 almdgivmgggVGLSvhgsfrvvtertrfampETAIGLFPDVGGSyflSRLPGELGLYLA----LTGARLNGADALAAGL 168


                  ....*.
gi 564390642  199 ISHVLE 204
Cdd:pfam16113 169 ATHYVP 174
PLN03214 PLN03214
probable enoyl-CoA hydratase/isomerase; Provisional
 77-238 5.16e-04

probable enoyl-CoA hydratase/isomerase; Provisional


Pssm-ID: 215635  Cd Length: 278  Bit Score: 40.63  E-value: 5.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642  77 NSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEV-PGIFCAGADLKER---------------------AKMHSSEVGPfV 134
Cdd:PLN03214  33 NSMTLAMWRSLDDALTALENDPTVRGVVFASGLrRDVFTAGNDIAELyapktsaaryaefwltqttflVRLLRSRLAT-V 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390642 135 SKIR----------AVIND---IASSAKMGLVETKLAI-IPGGGGTQRLPRAIGMALAKELIFSARVLDGQEAKAVGLIS 200
Cdd:PLN03214 112 CAIRgacpaggcavSLCCDyrlQTTEGTMGLNEVALGIpVPKFWARLFMGRVIDRKVAESLLLRGRLVRPAEAKQLGLID 191

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 564390642 201 HVLEQNQEGDAAYRKaldlAREFLPQGPVAMRVAKLAI 238
Cdd:PLN03214 192 EVVPAAALMEAAASA----MERALKLPSAARAATKALL 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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