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Conserved domains on  [gi|564388452|ref|XP_006252902|]
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zinc finger protein 14 isoform X1 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 39-80 3.48e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 3.48e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564388452   39 SVTFEDVAVNFTVEEWALLGPSQKKLHRDVMEETFRNLAAIG 80
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
288-730 1.84e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 288 KPYRCNTCDKAFTCLTNFQEHERTHTGEKPYLCTQ--CGKAFSFLSNIRRHERTHTGEKPYRCNICGKAFSYLTNFQDHE 365
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 366 RTHTGE-KPYVCTQCGKAFTYYYSFQthkrchtgeKPYVckqcgkaFSYYNSIQTHKRCHTGEKPyvcklCEKAFTTLSS 444
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQL---------PDLL-------SISNLRNNPLPGNNSSSVN-----TPQSNSLHPP 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 445 LRYHERIHSGEKPHvclqcgkgfnsssTLRIHERTHTGEKPYKCKQCGKVFSVDSSLRCHERIHSGEKPYVCKQCGKAFT 524
Cdd:COG5048  171 LPANSLSKDPSSNL-------------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 525 RH------TSLRCHERIHCGEKPYKCKQCGKGFISSSNFRKHEWTHSG-EKHCVCKLCGKAFTGHSSLRRHER--IHSGE 595
Cdd:COG5048  238 KSllsqspSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 596 --KPYVCKH--CGKGFSSLSGCQRHEQIHTGEKPHVCKS--CGKAFTNPSALRNHERIH-----------SGEKPCICEQ 658
Cdd:COG5048  318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQqykdlkndkksETLSNSCIRN 397

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564388452 659 CGKGfiSFSKFRIHERIHTGEKPYKCKQCGKAFTGHSSLRRHERIHSGEKPFVCKQCGKSFYTLSDCQRHEQ 730
Cdd:COG5048  398 FKRD--SNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 39-80 3.48e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 3.48e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564388452   39 SVTFEDVAVNFTVEEWALLGPSQKKLHRDVMEETFRNLAAIG 80
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
40-80 6.74e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 6.74e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 564388452    40 VTFEDVAVNFTVEEWALLGPSQKKLHRDVMEETFRNLAAIG 80
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 40-77 3.15e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.89  E-value: 3.15e-15
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564388452  40 VTFEDVAVNFTVEEWALLGPSQKKLHRDVMEETFRNLA 77
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
288-730 1.84e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 288 KPYRCNTCDKAFTCLTNFQEHERTHTGEKPYLCTQ--CGKAFSFLSNIRRHERTHTGEKPYRCNICGKAFSYLTNFQDHE 365
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 366 RTHTGE-KPYVCTQCGKAFTYYYSFQthkrchtgeKPYVckqcgkaFSYYNSIQTHKRCHTGEKPyvcklCEKAFTTLSS 444
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQL---------PDLL-------SISNLRNNPLPGNNSSSVN-----TPQSNSLHPP 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 445 LRYHERIHSGEKPHvclqcgkgfnsssTLRIHERTHTGEKPYKCKQCGKVFSVDSSLRCHERIHSGEKPYVCKQCGKAFT 524
Cdd:COG5048  171 LPANSLSKDPSSNL-------------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 525 RH------TSLRCHERIHCGEKPYKCKQCGKGFISSSNFRKHEWTHSG-EKHCVCKLCGKAFTGHSSLRRHER--IHSGE 595
Cdd:COG5048  238 KSllsqspSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 596 --KPYVCKH--CGKGFSSLSGCQRHEQIHTGEKPHVCKS--CGKAFTNPSALRNHERIH-----------SGEKPCICEQ 658
Cdd:COG5048  318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQqykdlkndkksETLSNSCIRN 397

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564388452 659 CGKGfiSFSKFRIHERIHTGEKPYKCKQCGKAFTGHSSLRRHERIHSGEKPFVCKQCGKSFYTLSDCQRHEQ 730
Cdd:COG5048  398 FKRD--SNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
276-301 3.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 564388452  276 NIRRHERTHTGEKPYRCNTCDKAFTC 301
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 39-80 3.48e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 3.48e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564388452   39 SVTFEDVAVNFTVEEWALLGPSQKKLHRDVMEETFRNLAAIG 80
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
40-80 6.74e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 6.74e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 564388452    40 VTFEDVAVNFTVEEWALLGPSQKKLHRDVMEETFRNLAAIG 80
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 40-77 3.15e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.89  E-value: 3.15e-15
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564388452  40 VTFEDVAVNFTVEEWALLGPSQKKLHRDVMEETFRNLA 77
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
288-730 1.84e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 288 KPYRCNTCDKAFTCLTNFQEHERTHTGEKPYLCTQ--CGKAFSFLSNIRRHERTHTGEKPYRCNICGKAFSYLTNFQDHE 365
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 366 RTHTGE-KPYVCTQCGKAFTYYYSFQthkrchtgeKPYVckqcgkaFSYYNSIQTHKRCHTGEKPyvcklCEKAFTTLSS 444
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQL---------PDLL-------SISNLRNNPLPGNNSSSVN-----TPQSNSLHPP 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 445 LRYHERIHSGEKPHvclqcgkgfnsssTLRIHERTHTGEKPYKCKQCGKVFSVDSSLRCHERIHSGEKPYVCKQCGKAFT 524
Cdd:COG5048  171 LPANSLSKDPSSNL-------------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 525 RH------TSLRCHERIHCGEKPYKCKQCGKGFISSSNFRKHEWTHSG-EKHCVCKLCGKAFTGHSSLRRHER--IHSGE 595
Cdd:COG5048  238 KSllsqspSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 596 --KPYVCKH--CGKGFSSLSGCQRHEQIHTGEKPHVCKS--CGKAFTNPSALRNHERIH-----------SGEKPCICEQ 658
Cdd:COG5048  318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQqykdlkndkksETLSNSCIRN 397

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564388452 659 CGKGfiSFSKFRIHERIHTGEKPYKCKQCGKAFTGHSSLRRHERIHSGEKPFVCKQCGKSFYTLSDCQRHEQ 730
Cdd:COG5048  398 FKRD--SNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
428-765 3.03e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.72  E-value: 3.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 428 KPYVCKLCEKAFTTLSSLRYHERIHSGEKPHVCLQ--CGKGFNSSSTLRIHERTHTGEKPYKCKQCGKVFSVDSSLRCHE 505
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 506 RIHSGE-KPYVCKQCGKAFTRHTSLRCHERIHCGEKPYKCKQCGKGFISSSN-FRKHEWTHSGEkhcvckLCGKAFTGHS 583
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsNSLHPPLPANS------LSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 584 SLRRHERIHSGEKPYVCKHCGK--GFSSLSGCQRHEQIHTGEKPHVCkSCGKAFTNPSALRNHE----RIHSGEKPCICE 657
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSsySIPSSSSDQNLENSSSSLPLTTN-SQLSPKSLLSQSPSSLsssdSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 658 QCGKGFISFSKFRIHERIHTG-EKPYKCKQCGKAFTGHSSLRRHER--IHSGE--KPFVC--KQCGKSFYTLSDCQRHEQ 730
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 564388452 731 IHTGEKPFICK--QCGKAFTRSSSLKIHEKTHSRRNS 765
Cdd:COG5048  345 LHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDL 381
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
400-764 2.12e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 2.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 400 KPYVCKQCGKAFSYYNSIQTHKRCHTGEKPYVC--KLCEKAFTTLSSLRYHERIHSGEKPHVCLQCGKGFNSSSTLRIHE 477
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 478 RTHTGE-KPYKCKQCGKVFSVDSSLRCHERIHSGEKPYVCKQCGKAF----------------------TRHTSLRCHER 534
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplpanslskdpSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 535 IHCGEKPYKCKQCGKGFISSSNFRKHEWTHSGEKHCVCKLCGKAFTGHSSLRRHERIHSGEKPYVCKHCGKGFSSLSGCQ 614
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 615 RHEQIHTGE-------KPHVCKSCGKAFTNPSALRNHER--IHSGE--KPCIC--EQCGKGFISFSKFRIHERIHTGEKP 681
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 682 YKCK--QCGKAFTG-----HSSLRRHERIHSGEKPFVC--KQCGKSFYTLSDCQRHEQIHTGEKP--FICKQCGKAFTRS 750
Cdd:COG5048  352 AKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                        410
                 ....*....|....
gi 564388452 751 SSLKIHEKTHSRRN 764
Cdd:COG5048  432 YNLIPHKKIHTNHA 445
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 678-761 3.23e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 678 GEKPYKCK--QCGKAFTGHSSLRRHeRIHSgekpfvckQCGKSFYTLSDCQRHEQIHTGEKPFICKQCGKAFTRSSSLKI 755
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 564388452 756 HeKTHS 761
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
276-301 3.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 564388452  276 NIRRHERTHTGEKPYRCNTCDKAFTC 301
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
332-357 3.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.64e-04
                          10        20
                  ....*....|....*....|....*.
gi 564388452  332 NIRRHERTHTGEKPYRCNICGKAFSY 357
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 538-616 6.85e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 6.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 538 GEKPYKCK--QCGKGFISSSNFRKHEWthsgEKHCVCKLcgkafTGHSSLRRHERIHSGEKPYVCKHCGKGFSSLSGCQR 615
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML----HGHQNQKL-----HENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 564388452 616 H 616
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
696-719 7.61e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.61e-04
                          10        20
                  ....*....|....*....|....
gi 564388452  696 SLRRHERIHSGEKPFVCKQCGKSF 719
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 426-509 8.51e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 8.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 426 GEKPYVCKL--CEKAFTTLSSLRYHeRIHSgekphvclQCGKGFNSSSTLRIHERTHTGEKPYKCKQCGKVFSVDSSLRC 503
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 564388452 504 HeRIHS 509
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
584-609 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 564388452  584 SLRRHERIHSGEKPYVCKHCGKGFSS 609
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
360-385 1.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 564388452  360 NFQDHERTHTGEKPYVCTQCGKAFTY 385
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 370-453 1.70e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564388452 370 GEKPYVC--TQCGKAFTYYYSFQTHKRcHtgekpyvcKQCGKAFSYYNSIQTHKRCHTGEKPYVCKLCEKAFTTLSSLRY 447
Cdd:COG5189  346 DGKPYKCpvEGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 564388452 448 HeRIHS 453
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
473-496 1.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.72e-03
                          10        20
                  ....*....|....*....|....
gi 564388452  473 LRIHERTHTGEKPYKCKQCGKVFS 496
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-328 2.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.22e-03
                          10        20
                  ....*....|....*....|....*
gi 564388452  304 NFQEHERTHTGEKPYLCTQCGKAFS 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
669-692 2.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.81e-03
                          10        20
                  ....*....|....*....|....
gi 564388452  669 FRIHERIHTGEKPYKCKQCGKAFT 692
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
388-413 3.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 564388452  388 SFQTHKRCHTGEKPYVCKQCGKAFSY 413
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
614-637 6.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.29e-03
                          10        20
                  ....*....|....*....|....
gi 564388452  614 QRHEQIHTGEKPHVCKSCGKAFTN 637
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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