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Conserved domains on  [gi|564387996|ref|XP_006252722|]
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nuclear receptor coactivator 4 isoform X1 [Rattus norvegicus]

Protein Classification

ARA70 domain-containing protein( domain architecture ID 10575819)

ARA70 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 207-333 4.75e-53

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


:

Pssm-ID: 463604  Cd Length: 135  Bit Score: 178.01  E-value: 4.75e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387996  207 VSLSEWLLVSKPAIGPQAPYVPSTNPQDWLTPKQTLENSQTSARICSD---AWGNLKGLENWLLNSHQQEIPGKPSSSKC 283
Cdd:pfam12489   1 VPLSEWLLGSKPISGCQAPYQPSTNLQDWLTQKQTKENSQVSARACSCfsrVWGNLRDLENWLLKQQQLVVPLKPEQQQL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 564387996  284 NSHCSTSSFSTEDEKVEDVEVLDQDEL----DLSDWLVTPQEPRDLEKPVNGRS 333
Cdd:pfam12489  81 NSLSGTSSFSIEQLKVSDLELLDQEEQltleDLSDWLLTPEESPKLEFPADSEK 134
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 46-155 1.62e-23

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


:

Pssm-ID: 463604  Cd Length: 135  Bit Score: 96.34  E-value: 1.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387996   46 EQQMKDNLrEVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEEtlQQQAQQLYwlmGQFNCLIHQLEITQNK--DLA 123
Cdd:pfam12489  32 QKQTKENS-QVSARACSCFSRVWGNLRDLENWLLKQQQLVVPLKPE--QQQLNSLS---GTSSFSIEQLKVSDLEllDQE 105

                          90       100       110
                  ....*....|....*....|....*....|..
gi 564387996  124 NQvaLCLERLGSLTLKPEDSTVLLFEADASAL 155
Cdd:pfam12489 106 EQ--LTLEDLSDWLLTPEESPKLEFPADSEKL 135
 
Name Accession Description Interval E-value
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 207-333 4.75e-53

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


Pssm-ID: 463604  Cd Length: 135  Bit Score: 178.01  E-value: 4.75e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387996  207 VSLSEWLLVSKPAIGPQAPYVPSTNPQDWLTPKQTLENSQTSARICSD---AWGNLKGLENWLLNSHQQEIPGKPSSSKC 283
Cdd:pfam12489   1 VPLSEWLLGSKPISGCQAPYQPSTNLQDWLTQKQTKENSQVSARACSCfsrVWGNLRDLENWLLKQQQLVVPLKPEQQQL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 564387996  284 NSHCSTSSFSTEDEKVEDVEVLDQDEL----DLSDWLVTPQEPRDLEKPVNGRS 333
Cdd:pfam12489  81 NSLSGTSSFSIEQLKVSDLELLDQEEQltleDLSDWLLTPEESPKLEFPADSEK 134
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 46-155 1.62e-23

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


Pssm-ID: 463604  Cd Length: 135  Bit Score: 96.34  E-value: 1.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387996   46 EQQMKDNLrEVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEEtlQQQAQQLYwlmGQFNCLIHQLEITQNK--DLA 123
Cdd:pfam12489  32 QKQTKENS-QVSARACSCFSRVWGNLRDLENWLLKQQQLVVPLKPE--QQQLNSLS---GTSSFSIEQLKVSDLEllDQE 105

                          90       100       110
                  ....*....|....*....|....*....|..
gi 564387996  124 NQvaLCLERLGSLTLKPEDSTVLLFEADASAL 155
Cdd:pfam12489 106 EQ--LTLEDLSDWLLTPEESPKLEFPADSEKL 135
BBC smart00502
B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains
 22-115 3.43e-03

B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains


Pssm-ID: 128778  Cd Length: 127  Bit Score: 38.01  E-value: 3.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387996    22 RETLLRCSDARRELELAIGGVLRAEQQMKDNLREVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEETLQQQAQQLY 101
Cdd:smart00502   6 EELLTKLRKKAAELEDALKQLISIIQEVEENAADVEAQIKAAFDELRNALNKRKKQLLEDLEEQKENKLKVLEQQLESLT 85

                           90
                   ....*....|....
gi 564387996   102 WLMGQFNCLIHQLE 115
Cdd:smart00502  86 QKQEKLSHAINFTE 99
 
Name Accession Description Interval E-value
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 207-333 4.75e-53

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


Pssm-ID: 463604  Cd Length: 135  Bit Score: 178.01  E-value: 4.75e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387996  207 VSLSEWLLVSKPAIGPQAPYVPSTNPQDWLTPKQTLENSQTSARICSD---AWGNLKGLENWLLNSHQQEIPGKPSSSKC 283
Cdd:pfam12489   1 VPLSEWLLGSKPISGCQAPYQPSTNLQDWLTQKQTKENSQVSARACSCfsrVWGNLRDLENWLLKQQQLVVPLKPEQQQL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 564387996  284 NSHCSTSSFSTEDEKVEDVEVLDQDEL----DLSDWLVTPQEPRDLEKPVNGRS 333
Cdd:pfam12489  81 NSLSGTSSFSIEQLKVSDLELLDQEEQltleDLSDWLLTPEESPKLEFPADSEK 134
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 46-155 1.62e-23

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


Pssm-ID: 463604  Cd Length: 135  Bit Score: 96.34  E-value: 1.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387996   46 EQQMKDNLrEVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEEtlQQQAQQLYwlmGQFNCLIHQLEITQNK--DLA 123
Cdd:pfam12489  32 QKQTKENS-QVSARACSCFSRVWGNLRDLENWLLKQQQLVVPLKPE--QQQLNSLS---GTSSFSIEQLKVSDLEllDQE 105

                          90       100       110
                  ....*....|....*....|....*....|..
gi 564387996  124 NQvaLCLERLGSLTLKPEDSTVLLFEADASAL 155
Cdd:pfam12489 106 EQ--LTLEDLSDWLLTPEESPKLEFPADSEKL 135
BBC smart00502
B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains
 22-115 3.43e-03

B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains


Pssm-ID: 128778  Cd Length: 127  Bit Score: 38.01  E-value: 3.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387996    22 RETLLRCSDARRELELAIGGVLRAEQQMKDNLREVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEETLQQQAQQLY 101
Cdd:smart00502   6 EELLTKLRKKAAELEDALKQLISIIQEVEENAADVEAQIKAAFDELRNALNKRKKQLLEDLEEQKENKLKVLEQQLESLT 85

                           90
                   ....*....|....
gi 564387996   102 WLMGQFNCLIHQLE 115
Cdd:smart00502  86 QKQEKLSHAINFTE 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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