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Conserved domains on  [gi|564386976|ref|XP_006252360|]
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fibronectin type-III domain-containing protein 3A isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
627-934 4.75e-16

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 4.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  627 DRLTPGCYYRLRVYCISDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPK-AKEIQLRWGPPQVDGgspISCYAVEMTPA 705
Cdd:COG3401   197 GDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPGSVTLSWDPVTESD---ATGYRVYRSNS 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  706 DKDEPRDVYQGSEVECTVSSLLPGKTYSFRLRAANRIGF-GPFSEKYDITTAPGPPDqcrPPQ-VTCRSATCAQV--NWE 781
Cdd:COG3401   272 GDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPA---APSgLTATAVGSSSItlSWT 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  782 ipLSNGTDITEYRLE-WGGVEGSMQ-ICYCGPGLSCELKGLSPATTYYCRVQALSVVG-AGPFSEVVACVTPPSVPAIVT 858
Cdd:COG3401   349 --ASSDADVTGYNVYrSTSGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESL 426

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564386976  859 CLQEIRDDDIEYPHYSPstclAISWEEPYDHGSEILAYSIDLGDKQPLTVGKVTSYVINSLQPDTTYRIRIQALNS 934
Cdd:COG3401   427 TASVDAVPLTDVAGATA----AASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVG 498
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
275-616 1.28e-15

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.59  E-value: 1.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  275 ASDIQARTVLLTWSPPSSFVNGEVTETTVPEFFNYEILVSSTGKegkyrSVYVGEETSVTLNDLKPATDYHAKVQAESNS 354
Cdd:COG3401   141 YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTS-----LTVTSTTLVDGGGDIEPGTTYYYRVAATDTG 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  355 IKGIPSEAESFTTLSCEPDTPNAPRIANRTKNSLTLQWKAPSDNGskIQSFILEWDEgKGSGEFCQCYMGSQKQFKITKL 434
Cdd:COG3401   216 GESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSN-SGDGPFTKVATVTTTSYTDTGL 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  435 SPAMGCKFRLSAKNDYGV-SDFSEEVLYYTSGCAPSVPASPVLTKAGVTWLSLQWTKPSG-----------TPSDEGISY 502
Cdd:COG3401   293 TNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDadvtgynvyrsTSGGGTYTK 372

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  503 ILEMEEETSgygfkpkydgedlaYTVKNLRRSTKYKFKVIAYNSEG-KSSPSEVVEFSTCPDKPGVPAKPSVKGKVHSHG 581
Cdd:COG3401   373 IAETVTTTS--------------YTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTASVDAVPLTDV 438

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 564386976  582 FKITW---DPPRDNGGAPINKYVVEMAEGSNGSKWDMI 616
Cdd:COG3401   439 AGATAaasAASNPGVSAAVLADGGDTGNAVPFTTTSST 476
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
873-1166 8.01e-12

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 69.65  E-value: 8.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  873 YSPSTCLAISWEEPYDHGSEILAYSIDLGDKQPLTVGKVTSYVINSLQPDTTYRIRIQALNSLGAGPFSHTIKLKTKPLP 952
Cdd:COG3401   153 ANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTP 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  953 PDPP-RLECVAFNHQNLKLKWGEGTpktlATDAVQYHL-QMEDKNGRFVSLYRGPCHTYKVQRLSESTSYKFCIQACNEA 1030
Cdd:COG3401   233 PSAPtGLTATADTPGSVTLSWDPVT----ESDATGYRVyRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976 1031 G-EGPLSQEYVFTTPKSVPAALKAPKIEKINDHICEITWeylQPMKGDPVI-YNLQVMVGKDSEFKQIYRGPD-TSFRYS 1107
Cdd:COG3401   309 GnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSW---TASSDADVTgYNVYRSTSGGGTYTKIAETVTtTSYTDT 385

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 564386976 1108 SLQLNCEYRFRVCAIrqcqDPAGhqdLVGPYSTTVFFISQRTEPLASSNRDTVDSARTR 1166
Cdd:COG3401   386 GLTPGTTYYYKVTAV----DAAG---NESAPSEEVSATTASAASGESLTASVDAVPLTD 437
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
627-934 4.75e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 4.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  627 DRLTPGCYYRLRVYCISDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPK-AKEIQLRWGPPQVDGgspISCYAVEMTPA 705
Cdd:COG3401   197 GDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPGSVTLSWDPVTESD---ATGYRVYRSNS 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  706 DKDEPRDVYQGSEVECTVSSLLPGKTYSFRLRAANRIGF-GPFSEKYDITTAPGPPDqcrPPQ-VTCRSATCAQV--NWE 781
Cdd:COG3401   272 GDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPA---APSgLTATAVGSSSItlSWT 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  782 ipLSNGTDITEYRLE-WGGVEGSMQ-ICYCGPGLSCELKGLSPATTYYCRVQALSVVG-AGPFSEVVACVTPPSVPAIVT 858
Cdd:COG3401   349 --ASSDADVTGYNVYrSTSGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESL 426

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564386976  859 CLQEIRDDDIEYPHYSPstclAISWEEPYDHGSEILAYSIDLGDKQPLTVGKVTSYVINSLQPDTTYRIRIQALNS 934
Cdd:COG3401   427 TASVDAVPLTDVAGATA----AASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVG 498
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
275-616 1.28e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.59  E-value: 1.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  275 ASDIQARTVLLTWSPPSSFVNGEVTETTVPEFFNYEILVSSTGKegkyrSVYVGEETSVTLNDLKPATDYHAKVQAESNS 354
Cdd:COG3401   141 YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTS-----LTVTSTTLVDGGGDIEPGTTYYYRVAATDTG 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  355 IKGIPSEAESFTTLSCEPDTPNAPRIANRTKNSLTLQWKAPSDNGskIQSFILEWDEgKGSGEFCQCYMGSQKQFKITKL 434
Cdd:COG3401   216 GESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSN-SGDGPFTKVATVTTTSYTDTGL 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  435 SPAMGCKFRLSAKNDYGV-SDFSEEVLYYTSGCAPSVPASPVLTKAGVTWLSLQWTKPSG-----------TPSDEGISY 502
Cdd:COG3401   293 TNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDadvtgynvyrsTSGGGTYTK 372

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  503 ILEMEEETSgygfkpkydgedlaYTVKNLRRSTKYKFKVIAYNSEG-KSSPSEVVEFSTCPDKPGVPAKPSVKGKVHSHG 581
Cdd:COG3401   373 IAETVTTTS--------------YTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTASVDAVPLTDV 438

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 564386976  582 FKITW---DPPRDNGGAPINKYVVEMAEGSNGSKWDMI 616
Cdd:COG3401   439 AGATAaasAASNPGVSAAVLADGGDTGNAVPFTTTSST 476
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 372-463 5.07e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.68  E-value: 5.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  372 PDTPNAPRIANRTKNSLTLQWKAPSDNGSKIQSFILEWDEgKGSGEFCQC--YMGSQKQFKITKLSPAMGCKFRLSAKND 449
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 564386976  450 YGVSDFSEEVLYYT 463
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 679-755 1.14e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 1.14e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564386976  679 EIQLRWGPPQvDGGSPISCYAVEMTPADKDEPRDV--YQGSEVECTVSSLLPGKTYSFRLRAANRIGFGPFSEKYDITT 755
Cdd:cd00063    16 SVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
873-1166 8.01e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 69.65  E-value: 8.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  873 YSPSTCLAISWEEPYDHGSEILAYSIDLGDKQPLTVGKVTSYVINSLQPDTTYRIRIQALNSLGAGPFSHTIKLKTKPLP 952
Cdd:COG3401   153 ANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTP 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  953 PDPP-RLECVAFNHQNLKLKWGEGTpktlATDAVQYHL-QMEDKNGRFVSLYRGPCHTYKVQRLSESTSYKFCIQACNEA 1030
Cdd:COG3401   233 PSAPtGLTATADTPGSVTLSWDPVT----ESDATGYRVyRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976 1031 G-EGPLSQEYVFTTPKSVPAALKAPKIEKINDHICEITWeylQPMKGDPVI-YNLQVMVGKDSEFKQIYRGPD-TSFRYS 1107
Cdd:COG3401   309 GnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSW---TASSDADVTgYNVYRSTSGGGTYTKIAETVTtTSYTDT 385

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 564386976 1108 SLQLNCEYRFRVCAIrqcqDPAGhqdLVGPYSTTVFFISQRTEPLASSNRDTVDSARTR 1166
Cdd:COG3401   386 GLTPGTTYYYKVTAV----DAAG---NESAPSEEVSATTASAASGESLTASVDAVPLTD 437
fn3 pfam00041
Fibronectin type III domain;
876-941 3.48e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 3.48e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564386976   876 STCLAISWEEPYDHGSEILAYSI------DLGDKQPLTVGKVT-SYVINSLQPDTTYRIRIQALNSLGAGPFS 941
Cdd:pfam00041   13 STSLTVSWTPPPDGNGPITGYEVeyrpknSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
272-360 4.76e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 4.76e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976   272 RPVASDIQARTVLLTWSPPSSfVNGEVTettvpeffNYEILVSSTGKEGKYRSVYV-GEETSVTLNDLKPATDYHAKVQA 350
Cdd:pfam00041    5 NLTVTDVTSTSLTVSWTPPPD-GNGPIT--------GYEVEYRPKNSGEPWNEITVpGTTTSVTLTGLKPGTEYEVRVQA 75

                           90
                   ....*....|
gi 564386976   351 ESNSIKGIPS 360
Cdd:pfam00041   76 VNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 757-839 3.11e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 3.11e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976    757 PGPPdqcRPPQVTCRSATCAQVNWEIPLSNGTD--ITEYRLEWGGVEGSMQICYCGPG-LSCELKGLSPATTYYCRVQAL 833
Cdd:smart00060    1 PSPP---SNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSsTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 564386976    834 SVVGAG 839
Cdd:smart00060   78 NGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 468-550 1.01e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 1.01e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976    468 PSVPASPVLTKAGVTWLSLQWTKPsgtPSDEGISYILEMEEETSGYGFKPK---YDGEDLAYTVKNLRRSTKYKFKVIAY 544
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPP---PDDGITGYIVGYRVEYREEGSEWKevnVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 564386976    545 NSEGKS 550
Cdd:smart00060   78 NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 953-1043 1.37e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  953 PDPPR-LECVAFNHQNLKLKWGEgtPKTLATDAVQYHLQMEDKNGRFVSLYRGPC---HTYKVQRLSESTSYKFCIQACN 1028
Cdd:cd00063     1 PSPPTnLRVTDVTSTSVTLSWTP--PEDDGGPITGYVVEYREKGSGDWKEVEVTPgseTSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 564386976 1029 EAGEGPLSQEYVFTT 1043
Cdd:cd00063    79 GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 952-1033 1.51e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 1.51e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976    952 PPDPPRLECVAFNHQNLKLKWGEGTPKTLATDAVQYHLQMEDKNGRFVSLYRGPCHT-YKVQRLSESTSYKFCIQACNEA 1030
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 564386976   1031 GEG 1033
Cdd:smart00060   81 GEG 83
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
627-934 4.75e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 4.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  627 DRLTPGCYYRLRVYCISDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPK-AKEIQLRWGPPQVDGgspISCYAVEMTPA 705
Cdd:COG3401   197 GDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPGSVTLSWDPVTESD---ATGYRVYRSNS 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  706 DKDEPRDVYQGSEVECTVSSLLPGKTYSFRLRAANRIGF-GPFSEKYDITTAPGPPDqcrPPQ-VTCRSATCAQV--NWE 781
Cdd:COG3401   272 GDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPA---APSgLTATAVGSSSItlSWT 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  782 ipLSNGTDITEYRLE-WGGVEGSMQ-ICYCGPGLSCELKGLSPATTYYCRVQALSVVG-AGPFSEVVACVTPPSVPAIVT 858
Cdd:COG3401   349 --ASSDADVTGYNVYrSTSGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESL 426

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564386976  859 CLQEIRDDDIEYPHYSPstclAISWEEPYDHGSEILAYSIDLGDKQPLTVGKVTSYVINSLQPDTTYRIRIQALNS 934
Cdd:COG3401   427 TASVDAVPLTDVAGATA----AASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVG 498
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
275-616 1.28e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.59  E-value: 1.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  275 ASDIQARTVLLTWSPPSSFVNGEVTETTVPEFFNYEILVSSTGKegkyrSVYVGEETSVTLNDLKPATDYHAKVQAESNS 354
Cdd:COG3401   141 YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTS-----LTVTSTTLVDGGGDIEPGTTYYYRVAATDTG 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  355 IKGIPSEAESFTTLSCEPDTPNAPRIANRTKNSLTLQWKAPSDNGskIQSFILEWDEgKGSGEFCQCYMGSQKQFKITKL 434
Cdd:COG3401   216 GESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSN-SGDGPFTKVATVTTTSYTDTGL 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  435 SPAMGCKFRLSAKNDYGV-SDFSEEVLYYTSGCAPSVPASPVLTKAGVTWLSLQWTKPSG-----------TPSDEGISY 502
Cdd:COG3401   293 TNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDadvtgynvyrsTSGGGTYTK 372

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  503 ILEMEEETSgygfkpkydgedlaYTVKNLRRSTKYKFKVIAYNSEG-KSSPSEVVEFSTCPDKPGVPAKPSVKGKVHSHG 581
Cdd:COG3401   373 IAETVTTTS--------------YTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTASVDAVPLTDV 438

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 564386976  582 FKITW---DPPRDNGGAPINKYVVEMAEGSNGSKWDMI 616
Cdd:COG3401   439 AGATAaasAASNPGVSAAVLADGGDTGNAVPFTTTSST 476
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 372-463 5.07e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.68  E-value: 5.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  372 PDTPNAPRIANRTKNSLTLQWKAPSDNGSKIQSFILEWDEgKGSGEFCQC--YMGSQKQFKITKLSPAMGCKFRLSAKND 449
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 564386976  450 YGVSDFSEEVLYYT 463
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
274-613 6.71e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.19  E-value: 6.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  274 VASDIQARTVLLTWSPPSsfvNGEVTettvpeffNYEILVSSTGkEGKYRSVYVGEETSVTLNDLKPATDYHAKVQAE-S 352
Cdd:COG3401   240 TATADTPGSVTLSWDPVT---ESDAT--------GYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdA 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  353 NSIKGIPSEAESFTTLSCEPDTPNAPRIANRTKNSLTLQWKAPSDNGskIQSFILEWDEGkGSGEFCQ-CYMGSQKQFKI 431
Cdd:COG3401   308 AGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAD--VTGYNVYRSTS-GGGTYTKiAETVTTTSYTD 384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  432 TKLSPAMGCKFRLSAKNDYGV-SDFSEEVlyytSGCAPSVPASPVLTKAGVTW---LSLQWTKPSGTPSDEGISYILEME 507
Cdd:COG3401   385 TGLTPGTTYYYKVTAVDAAGNeSAPSEEV----SATTASAASGESLTASVDAVpltDVAGATAAASAASNPGVSAAVLAD 460

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  508 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSSPsevvefSTCPDKPGVPAKPSVKGKVHSHGFKITWD 587
Cdd:COG3401   461 GGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSV------TNSVSVIGASAAAAVGGAPDGTPNVTGAS 534

                         330       340
                  ....*....|....*....|....*.
gi 564386976  588 PPRDNGGAPINKYVVEMAEGSNGSKW 613
Cdd:COG3401   535 PVTVGASTGDVLITDLVSLTTSASSS 560
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 468-560 1.91e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 1.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  468 PSVPASPVLTKAGVTWLSLQWTKPSGTPSdEGISYILEMEEETSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 546
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 564386976  547 EGKSSPSEVVEFST 560
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 679-755 1.14e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 1.14e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564386976  679 EIQLRWGPPQvDGGSPISCYAVEMTPADKDEPRDV--YQGSEVECTVSSLLPGKTYSFRLRAANRIGFGPFSEKYDITT 755
Cdd:cd00063    16 SVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 876-948 2.54e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.05  E-value: 2.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  876 STCLAISWEEPYDHGSEILAYSI---DLGDKQPLTV----GKVTSYVINSLQPDTTYRIRIQALNSLGAGPFSHTIKLKT 948
Cdd:cd00063    14 STSVTLSWTPPEDDGGPITGYVVeyrEKGSGDWKEVevtpGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 757-849 5.29e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 5.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  757 PGPPdqcRPPQVTCRSATCAQVNWEIPLSNGTDITEYRLEWGGV-EGSMQIC--YCGPGLSCELKGLSPATTYYCRVQAL 833
Cdd:cd00063     1 PSPP---TNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 564386976  834 SVVGAGPFSEVVACVT 849
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
873-1166 8.01e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 69.65  E-value: 8.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  873 YSPSTCLAISWEEPYDHGSEILAYSIDLGDKQPLTVGKVTSYVINSLQPDTTYRIRIQALNSLGAGPFSHTIKLKTKPLP 952
Cdd:COG3401   153 ANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTP 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  953 PDPP-RLECVAFNHQNLKLKWGEGTpktlATDAVQYHL-QMEDKNGRFVSLYRGPCHTYKVQRLSESTSYKFCIQACNEA 1030
Cdd:COG3401   233 PSAPtGLTATADTPGSVTLSWDPVT----ESDATGYRVyRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976 1031 G-EGPLSQEYVFTTPKSVPAALKAPKIEKINDHICEITWeylQPMKGDPVI-YNLQVMVGKDSEFKQIYRGPD-TSFRYS 1107
Cdd:COG3401   309 GnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSW---TASSDADVTgYNVYRSTSGGGTYTKIAETVTtTSYTDT 385

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 564386976 1108 SLQLNCEYRFRVCAIrqcqDPAGhqdLVGPYSTTVFFISQRTEPLASSNRDTVDSARTR 1166
Cdd:COG3401   386 GLTPGTTYYYKVTAV----DAAG---NESAPSEEVSATTASAASGESLTASVDAVPLTD 437
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 268-367 8.75e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.43  E-value: 8.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  268 SNIVRPVASDIQARTVLLTWSPPSSFvNGEVTettvpeffNYEILVSSTGKEGKYR-SVYVGEETSVTLNDLKPATDYHA 346
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDD-GGPIT--------GYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|.
gi 564386976  347 KVQAESNSIKGIPSEAESFTT 367
Cdd:cd00063    73 RVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 565-658 1.40e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.05  E-value: 1.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  565 PGVPAKPSVKGkVHSHGFKITWDPPRDNGGaPINKYVVEMAEgSNGSKWDMI--YSGATREHLCDRLTPGCYYRLRVYCI 642
Cdd:cd00063     1 PSPPTNLRVTD-VTSTSVTLSWTPPEDDGG-PITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 564386976  643 SDGGQSAVSESLLVQT 658
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
876-941 3.48e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 3.48e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564386976   876 STCLAISWEEPYDHGSEILAYSI------DLGDKQPLTVGKVT-SYVINSLQPDTTYRIRIQALNSLGAGPFS 941
Cdd:pfam00041   13 STSLTVSWTPPPDGNGPITGYEVeyrpknSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
272-360 4.76e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 4.76e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976   272 RPVASDIQARTVLLTWSPPSSfVNGEVTettvpeffNYEILVSSTGKEGKYRSVYV-GEETSVTLNDLKPATDYHAKVQA 350
Cdd:pfam00041    5 NLTVTDVTSTSLTVSWTPPPD-GNGPIT--------GYEVEYRPKNSGEPWNEITVpGTTTSVTLTGLKPGTEYEVRVQA 75

                           90
                   ....*....|
gi 564386976   351 ESNSIKGIPS 360
Cdd:pfam00041   76 VNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
764-842 1.19e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.88  E-value: 1.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976   764 RPPQVTCRSATCAQVNWEIPLSNGTDITEYRLEW---GGVEGSMQICYCGPGLSCELKGLSPATTYYCRVQALSVVGAGP 840
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83


                   ..
gi 564386976   841 FS 842
Cdd:pfam00041   84 PS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 757-839 3.11e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 3.11e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976    757 PGPPdqcRPPQVTCRSATCAQVNWEIPLSNGTD--ITEYRLEWGGVEGSMQICYCGPG-LSCELKGLSPATTYYCRVQAL 833
Cdd:smart00060    1 PSPP---SNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSsTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 564386976    834 SVVGAG 839
Cdd:smart00060   78 NGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 663-745 8.76e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 8.76e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976    663 PGPclPPRLQGRPKAKE-IQLRWGPPQVDGG-SPISCYAVEMTPADKDEPRDVYQGSEVECTVSSLLPGKTYSFRLRAAN 740
Cdd:smart00060    1 PSP--PSNLRVTDVTSTsVTLSWEPPPDDGItGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 564386976    741 RIGFG 745
Cdd:smart00060   79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 468-550 1.01e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 1.01e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976    468 PSVPASPVLTKAGVTWLSLQWTKPsgtPSDEGISYILEMEEETSGYGFKPK---YDGEDLAYTVKNLRRSTKYKFKVIAY 544
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPP---PDDGITGYIVGYRVEYREEGSEWKevnVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 564386976    545 NSEGKS 550
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
679-748 1.16e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.16e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564386976   679 EIQLRWGPPQvDGGSPISCYAVEMTPADKDEPRDVYQ--GSEVECTVSSLLPGKTYSFRLRAANRIGFGPFS 748
Cdd:pfam00041   15 SLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 372-453 2.15e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 2.15e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976    372 PDTPNAPRIANRTKNSLTLQWKAPSDNG--SKIQSFILEWDEGKGSGEFCQCyMGSQKQFKITKLSPAMGCKFRLSAKND 449
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 564386976    450 YGVS 453
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
373-456 2.66e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.42  E-value: 2.66e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976   373 DTPNAPRIANRTKNSLTLQWKAPSDNGSKIQSFILEWdEGKGSGEFCQCYM--GSQKQFKITKLSPAMGCKFRLSAKNDY 450
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEY-RPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 564386976   451 GVSDFS 456
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 876-938 3.34e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.85  E-value: 3.34e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976    876 STCLAISWEEPYDHG--SEILAYSIDLGDKQPL-----TVGKVTSYVINSLQPDTTYRIRIQALNSLGAG 938
Cdd:smart00060   14 STSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 953-1043 1.37e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  953 PDPPR-LECVAFNHQNLKLKWGEgtPKTLATDAVQYHLQMEDKNGRFVSLYRGPC---HTYKVQRLSESTSYKFCIQACN 1028
Cdd:cd00063     1 PSPPTnLRVTDVTSTSVTLSWTP--PEDDGGPITGYVVEYREKGSGDWKEVEVTPgseTSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 564386976 1029 EAGEGPLSQEYVFTT 1043
Cdd:cd00063    79 GGGESPPSESVTVTT 93
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
584-743 5.31e-07

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 54.18  E-value: 5.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  584 ITWDPPRDNGGAPINKYvvemaegSNGSKWDMIYSGATREHLCDRLTPGCYYrLRVYCISDGGQS----AVSESLLVQTP 659
Cdd:COG4733   556 VSWDAPAGAVAYEVEWR-------RDDGNWVSVPRTSGTSFEVPGIYAGDYE-VRVRAINALGVSsawaASSETTVTGKT 627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  660 AVPPGPclpPRLQGRPKAKEIQLRWGPPqVDGGSP---IScYAVEMTPADKDEPRDVYQGSEVecTVSSLLPGKTYSFRL 736
Cdd:COG4733   628 APPPAP---TGLTATGGLGGITLSWSFP-VDADTLrteIR-YSTTGDWASATVAQALYPGNTY--TLAGLKAGQTYYYRA 700


                  ....*..
gi 564386976  737 RAANRIG 743
Cdd:COG4733   701 RAVDRSG 707
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 952-1033 1.51e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 1.51e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976    952 PPDPPRLECVAFNHQNLKLKWGEGTPKTLATDAVQYHLQMEDKNGRFVSLYRGPCHT-YKVQRLSESTSYKFCIQACNEA 1030
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 564386976   1031 GEG 1033
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 565-648 3.21e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 3.21e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976    565 PGVPAKPSVKGkVHSHGFKITWDPP-RDNGGAPINKYVVEMaeGSNGSKWDMIY-SGATREHLCDRLTPGCYYRLRVYCI 642
Cdd:smart00060    1 PSPPSNLRVTD-VTSTSVTLSWEPPpDDGITGYIVGYRVEY--REEGSEWKEVNvTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 564386976    643 SDGGQS 648
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
469-553 3.29e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.25  E-value: 3.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976   469 SVPASPVLTKAGVTWLSLQWTKPSgTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YTVKNLRRSTKYKFKVIAYNSE 547
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 564386976   548 GKSSPS 553
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 268-353 7.75e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 7.75e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976    268 SNIVRPVASDIQARTVLLTWSPPSS-FVNGEVTEttvpeffnYEILVSSTGKEGKYRSVyVGEETSVTLNDLKPATDYHA 346
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVG--------YRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEF 72


                    ....*..
gi 564386976    347 KVQAESN 353
Cdd:smart00060   73 RVRAVNG 79
fn3 pfam00041
Fibronectin type III domain;
579-651 3.93e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 3.93e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564386976   579 SHGFKITWDPPRDNGGaPINKYVVEMAEGSNGSKWDMIY-SGATREHLCDRLTPGCYYRLRVYCISDGGQSAVS 651
Cdd:pfam00041   13 STSLTVSWTPPPDGNG-PITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1048-1145 1.06e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.40  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976 1048 PAALKAPKIEKINDHICEITWEYLQPMKGDPVIYNLQVMVGKDSEFKQI--YRGPDTSFRYSSLQLNCEYRFRVCAIRqc 1125
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVN-- 78

                          90       100
                  ....*....|....*....|
gi 564386976 1126 qdpaghQDLVGPYSTTVFFI 1145
Cdd:cd00063    79 ------GGGESPPSESVTVT 92
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
468-649 1.19e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.40  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  468 PSVPASPVLTK----AGVTWLSLQWTKPSGTPS------DEGISYILEMEEETSGYGFKPKYDGEdlaytvknlrrstkY 537
Cdd:COG4733   534 VNVTTSESLSVvaqgTAVTTLTVSWDAPAGAVAyevewrRDDGNWVSVPRTSGTSFEVPGIYAGD--------------Y 599

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  538 KFKVIAYNSEGKSSPSEVVEFSTCPDKPGVPAKPS---VKGKVhsHGFKITWDPPRDnggAPINKYVVEMAEGSNGSKWD 614
Cdd:COG4733   600 EVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTgltATGGL--GGITLSWSFPVD---ADTLRTEIRYSTTGDWASAT 674

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 564386976  615 MI-YSGATREHLCDRLTPGCYYRLRVYCISDGGQSA 649
Cdd:COG4733   675 VAqALYPGNTYTLAGLKAGQTYYYRARAVDRSGNVS 710
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 280-367 1.65e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 38.93  E-value: 1.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976   280 ARTVLLTWSPPSSFVNGEVTETTVPEffNYEILVSSTGKEGKYRSVYVGEETSVTLNDLKPATDYHAKVQAESnsikGIP 359
Cdd:pfam16656   12 STSMTVSWVTPSAVTSPVVQYGTSSS--ALTSTATATSSTYTTGDGGTGYIHRATLTGLEPGTTYYYRVGDDN----GGW 85


                   ....*...
gi 564386976   360 SEAESFTT 367
Cdd:pfam16656   86 SEVYSFTT 93
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
636-868 1.67e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 42.62  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  636 RLRVYCISDGGQSAVSESLLVQTPAV----------PPGPCLPP-----------RLQGRPKAKeIQLRWGPPQVDGGsp 694
Cdd:COG4733   490 LFRVVSIEENEDGTYTITAVQHAPEKyaaidagafdDVPPQWPPvnvttseslsvVAQGTAVTT-LTVSWDAPAGAVA-- 566

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  695 iscYAVEMTPADKDEpRDVYQGSEVECTVSSLLPGkTYSFRLRAANRIG---FGPFSEKYDITTAPGPPdqcrpPQVTcr 771
Cdd:COG4733   567 ---YEVEWRRDDGNW-VSVPRTSGTSFEVPGIYAG-DYEVRVRAINALGvssAWAASSETTVTGKTAPP-----PAPT-- 634

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564386976  772 SATCAQVNWEIPLS----NGTDITEYRLEWGGV---EGSMQICYCGPGLSCELKGLSPATTYYCRVQALSVVGAGPFSEV 844
Cdd:COG4733   635 GLTATGGLGGITLSwsfpVDADTLRTEIRYSTTgdwASATVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWV 714

                         250       260
                  ....*....|....*....|....
gi 564386976  845 VACVTPPSVPAIVTCLQEIRDDDI 868
Cdd:COG4733   715 SGQASADAAGILDAITGQILETEL 738
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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