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Conserved domains on  [gi|564381909|ref|XP_006250389|]
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kynurenine 3-monooxygenase isoform X2 [Rattus norvegicus]

Protein Classification

FAD-dependent oxidoreductase( domain architecture ID 11428987)

FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

CATH:  3.50.50.60
EC:  1.-.-.-
Gene Ontology:  GO:0071949|GO:0016491

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 8-297 3.47e-16

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 79.21  E-value: 3.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909   8 IVSKGVPMKARMIH-SLSGKK-SAIPYG-NKSQYILSISREKLNKDLLTAVESYpNAKVHFGHKLSKCCPEEGILTML-- 82
Cdd:COG0654   64 LLARGAPIRGIRVRdGSDGRVlARFDAAeTGLPAGLVVPRADLERALLEAARAL-GVELRFGTEVTGLEQDADGVTVTla 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  83 -GpnkvpRDITCDLIVGCDGAYSTVRAHLMKKPR-FDYSQQYIphgymeltippkngeyamepnclhiWprnafmmialp 160
Cdd:COG0654  143 dG-----RTLRADLVVGADGARSAVRRLLGIGFTgRDYPQRAL-------------------------W----------- 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909 161 nmdksftctlfmsfeefeklpthSDVLDFFQKNFPDAIPLMGEqalMRDFFLLPAQPMISVKCSPFHlKSRCVLMGDAAH 240
Cdd:COG0654  182 -----------------------AGVRTELRARLAAAGPRLGE---LLELSPRSAFPLRRRRAERWR-RGRVVLLGDAAH 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564381909 241 AIVPFFGQGMNAGFEDCLVFDELMDKF--NNDLSVCLPEFSRFRIPDDHAISDLSMYNY 297
Cdd:COG0654  235 TMHPLGGQGANLALRDAAALAWKLAAAlrGRDDEAALARYERERRPRAARVQRAADALG 293
 
Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 8-297 3.47e-16

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 79.21  E-value: 3.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909   8 IVSKGVPMKARMIH-SLSGKK-SAIPYG-NKSQYILSISREKLNKDLLTAVESYpNAKVHFGHKLSKCCPEEGILTML-- 82
Cdd:COG0654   64 LLARGAPIRGIRVRdGSDGRVlARFDAAeTGLPAGLVVPRADLERALLEAARAL-GVELRFGTEVTGLEQDADGVTVTla 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  83 -GpnkvpRDITCDLIVGCDGAYSTVRAHLMKKPR-FDYSQQYIphgymeltippkngeyamepnclhiWprnafmmialp 160
Cdd:COG0654  143 dG-----RTLRADLVVGADGARSAVRRLLGIGFTgRDYPQRAL-------------------------W----------- 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909 161 nmdksftctlfmsfeefeklpthSDVLDFFQKNFPDAIPLMGEqalMRDFFLLPAQPMISVKCSPFHlKSRCVLMGDAAH 240
Cdd:COG0654  182 -----------------------AGVRTELRARLAAAGPRLGE---LLELSPRSAFPLRRRRAERWR-RGRVVLLGDAAH 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564381909 241 AIVPFFGQGMNAGFEDCLVFDELMDKF--NNDLSVCLPEFSRFRIPDDHAISDLSMYNY 297
Cdd:COG0654  235 TMHPLGGQGANLALRDAAALAWKLAAAlrGRDDEAALARYERERRPRAARVQRAADALG 293
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 47-289 7.68e-09

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 57.21  E-value: 7.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909   47 LNKDLLTAVESYPNAKVHFGHKLS--KCCPEEGILTmLGPNKVprdITCDLIVGCDGAYSTVRAHL-MKKPRFDYSQQYI 123
Cdd:TIGR01988 108 LQQALWERLQELPNVTLLCPARVVelPRHSDHVELT-LDDGQQ---LRARLLVGADGANSKVRQLAgIPTTGWDYGQSAV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  124 --------PHGY--MELTIPpkNGEYAM----EPNCLHIW---PRNAFMMIALPnmdksftctlfmsFEEFeklpthsdv 186
Cdd:TIGR01988 184 vanvkherPHQGtaWERFTP--TGPLALlplpDNRSSLVWtlpPEEAERLLALS-------------DEEF--------- 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  187 LDFFQKNFPdaiPLMGEQALMRDFFLLPAQPMISVKcspfHLKSRCVLMGDAAHAIVPFFGQGMNAGFED------CLVF 260
Cdd:TIGR01988 240 LAELQRAFG---SRLGAITLVGERHAFPLSLTHAKR----YVAPRLALIGDAAHTIHPLAGQGLNLGLRDvaalaeVLED 312

                         250       260
                  ....*....|....*....|....*....
gi 564381909  261 DELMDKFNNDLSVcLPEFSRFRIPDDHAI 289
Cdd:TIGR01988 313 ARRRGEDIGSLRV-LQRYERRRRFDNAAM 340
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
51-256 1.14e-08

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 56.84  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  51 LLTAVESYPNAKVHFGHKLSKCCPEEG--ILTMLGPNKVPRDITCDLIVGCDGAYSTVRaHLMKKPRFDYSQqyiPHGYM 128
Cdd:PRK06183 119 LRAGLARFPHVRVRFGHEVTALTQDDDgvTVTLTDADGQRETVRARYVVGCDGANSFVR-RTLGVPFEDLTF---PERWL 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909 129 ELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFtctlfmsfeEFEKLP--THSDVLDffqknfPDAIplmgeQAL 206
Cdd:PRK06183 195 VVDVLIANDPLGGPHTYQYCDPARPYTSVRLPHGRRRW---------EFMLLPgeTEEQLAS------PENV-----WRL 254

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564381909 207 MRDFFLLPAQP-MISVKCSPFHL-------KSRCVLMGDAAHAIVPFFGQGMNAGFED 256
Cdd:PRK06183 255 LAPWGPTPDDAeLIRHAVYTFHArvadrwrSGRVLLAGDAAHLMPPFAGQGMNSGIRD 312
 
Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 8-297 3.47e-16

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 79.21  E-value: 3.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909   8 IVSKGVPMKARMIH-SLSGKK-SAIPYG-NKSQYILSISREKLNKDLLTAVESYpNAKVHFGHKLSKCCPEEGILTML-- 82
Cdd:COG0654   64 LLARGAPIRGIRVRdGSDGRVlARFDAAeTGLPAGLVVPRADLERALLEAARAL-GVELRFGTEVTGLEQDADGVTVTla 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  83 -GpnkvpRDITCDLIVGCDGAYSTVRAHLMKKPR-FDYSQQYIphgymeltippkngeyamepnclhiWprnafmmialp 160
Cdd:COG0654  143 dG-----RTLRADLVVGADGARSAVRRLLGIGFTgRDYPQRAL-------------------------W----------- 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909 161 nmdksftctlfmsfeefeklpthSDVLDFFQKNFPDAIPLMGEqalMRDFFLLPAQPMISVKCSPFHlKSRCVLMGDAAH 240
Cdd:COG0654  182 -----------------------AGVRTELRARLAAAGPRLGE---LLELSPRSAFPLRRRRAERWR-RGRVVLLGDAAH 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564381909 241 AIVPFFGQGMNAGFEDCLVFDELMDKF--NNDLSVCLPEFSRFRIPDDHAISDLSMYNY 297
Cdd:COG0654  235 TMHPLGGQGANLALRDAAALAWKLAAAlrGRDDEAALARYERERRPRAARVQRAADALG 293
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
20-149 7.34e-09

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 56.51  E-value: 7.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  20 IHSLSGKKSAIPYGNKSQYIlsISREKLNKDLLTAVESYpNAKVHFGHKLSKCCPEEGILTMLGPNkvPRDITCDLIVGC 99
Cdd:COG0644   63 FYSPGGKSVELPPGRGGGYV--VDRARFDRWLAEQAEEA-GAEVRTGTRVTDVLRDDGRVVVRTGD--GEEIRADYVVDA 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564381909 100 DGAYSTVRAHLMKKPRFDYSQQYIpHGYMELTIPPKNGEYamEPNCLHIW 149
Cdd:COG0644  138 DGARSLLARKLGLKRRSDEPQDYA-LAIKEHWELPPLEGV--DPGAVEFF 184
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 47-289 7.68e-09

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 57.21  E-value: 7.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909   47 LNKDLLTAVESYPNAKVHFGHKLS--KCCPEEGILTmLGPNKVprdITCDLIVGCDGAYSTVRAHL-MKKPRFDYSQQYI 123
Cdd:TIGR01988 108 LQQALWERLQELPNVTLLCPARVVelPRHSDHVELT-LDDGQQ---LRARLLVGADGANSKVRQLAgIPTTGWDYGQSAV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  124 --------PHGY--MELTIPpkNGEYAM----EPNCLHIW---PRNAFMMIALPnmdksftctlfmsFEEFeklpthsdv 186
Cdd:TIGR01988 184 vanvkherPHQGtaWERFTP--TGPLALlplpDNRSSLVWtlpPEEAERLLALS-------------DEEF--------- 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  187 LDFFQKNFPdaiPLMGEQALMRDFFLLPAQPMISVKcspfHLKSRCVLMGDAAHAIVPFFGQGMNAGFED------CLVF 260
Cdd:TIGR01988 240 LAELQRAFG---SRLGAITLVGERHAFPLSLTHAKR----YVAPRLALIGDAAHTIHPLAGQGLNLGLRDvaalaeVLED 312

                         250       260
                  ....*....|....*....|....*....
gi 564381909  261 DELMDKFNNDLSVcLPEFSRFRIPDDHAI 289
Cdd:TIGR01988 313 ARRRGEDIGSLRV-LQRYERRRRFDNAAM 340
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
51-256 1.14e-08

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 56.84  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  51 LLTAVESYPNAKVHFGHKLSKCCPEEG--ILTMLGPNKVPRDITCDLIVGCDGAYSTVRaHLMKKPRFDYSQqyiPHGYM 128
Cdd:PRK06183 119 LRAGLARFPHVRVRFGHEVTALTQDDDgvTVTLTDADGQRETVRARYVVGCDGANSFVR-RTLGVPFEDLTF---PERWL 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909 129 ELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFtctlfmsfeEFEKLP--THSDVLDffqknfPDAIplmgeQAL 206
Cdd:PRK06183 195 VVDVLIANDPLGGPHTYQYCDPARPYTSVRLPHGRRRW---------EFMLLPgeTEEQLAS------PENV-----WRL 254

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564381909 207 MRDFFLLPAQP-MISVKCSPFHL-------KSRCVLMGDAAHAIVPFFGQGMNAGFED 256
Cdd:PRK06183 255 LAPWGPTPDDAeLIRHAVYTFHArvadrwrSGRVLLAGDAAHLMPPFAGQGMNSGIRD 312
PRK07364 PRK07364
FAD-dependent hydroxylase;
51-256 3.74e-08

FAD-dependent hydroxylase;


Pssm-ID: 236001 [Multi-domain]  Cd Length: 415  Bit Score: 55.03  E-value: 3.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  51 LLTAVESYPNakvhfghkLSKCCPEEGILTMLGPNKV---------PRDITCDLIVGCDGAYSTVRAHLMKKPR-FDYSQ 120
Cdd:PRK07364 127 LQEFLQSCPN--------ITWLCPAEVVSVEYQQDAAtvtleiegkQQTLQSKLVVAADGARSPIRQAAGIKTKgWKYWQ 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909 121 QYI--------PHGYMeltippkngeyAMEpnclHIWPRNAFMMIALPNMDKSFTCTlfMSFEEFEKLPT--HSDVLDFF 190
Cdd:PRK07364 199 SCVtatvkheaPHNDI-----------AYE----RFWPSGPFAILPLPGNRCQIVWT--APHAQAKALLAlpEAEFLAEL 261

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564381909 191 QKNFPDaipLMGEQALMRDFFLLPAQPMISVKcspfHLKSRCVLMGDAAHAIVPFFGQGMNAGFED 256
Cdd:PRK07364 262 QQRYGD---QLGKLELLGDRFLFPVQLMQSDR----YVQHRLALVGDAAHCCHPVGGQGLNLGIRD 320
COQ6 TIGR01989
ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase ...
 89-256 1.60e-07

ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase responsible for the 4-hydroxylateion of the phenol ring in the aerobic biosynthesis of ubiquinone


Pssm-ID: 273914 [Multi-domain]  Cd Length: 437  Bit Score: 53.22  E-value: 1.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909   89 RDITCDLIVGCDGAYSTVR-AHLMKKPRFDYSQQYIPhGYMELTIPPKN----------GEYAMEP----NCLHIW---P 150
Cdd:TIGR01989 168 QVLYTKLLIGADGSNSNVRkAANIDTTGWNYNQHAVV-ATLKLEEATENdvawqrflptGPIALLPlpdnNSTLVWstsP 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  151 RNAFMMIALPnmDKSFTCTLFMSFE-EFEKLPtHSDVLDFFQKNFPDAIPLMGEQAlMRDFFLLPAqpMISVKCS----- 224
Cdd:TIGR01989 247 EEALRLLSLP--PEDFVDALNAAFDlGYSDHP-YSYLLDYAMEKLNEDIGFRTEGS-KSCFQVPPR--VIGVVDKsraaf 320

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 564381909  225 PFHL-------KSRCVLMGDAAHAIVPFFGQGMNAGFED 256
Cdd:TIGR01989 321 PLGLghadeyvTKRVALVGDAAHRVHPLAGQGVNLGFGD 359
PRK06753 PRK06753
hypothetical protein; Provisional
 40-284 2.23e-07

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 52.77  E-value: 2.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  40 LSISReklnKDLLTAVESY-PNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDItcDLIVGCDGAYSTVRAHLMKKPRFDY 118
Cdd:PRK06753  93 VTLHR----QTLIDIIKSYvKEDAIFTGKEVTKIENETDKVTIHFADGESEAF--DLCIGADGIHSKVRQSVNADSKVRY 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909 119 SqqyiphGY-----MELTIPPKNGEYAMEpnclhIW-PRNAFMMIALPNMDKSFtctlFMSFEEFEKLPTHSDV----LD 188
Cdd:PRK06753 167 Q------GYtcfrgLIDDIDLKLPDCAKE-----YWgTKGRFGIVPLLNNQAYW----FITINAKERDPKYSSFgkphLQ 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909 189 FFQKNFPDAIPLMGEQA-----LMRDFFLLpaQPMISvkcspfHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVfdeL 263
Cdd:PRK06753 232 AYFNHYPNEVREILDKQsetgiLHHDIYDL--KPLKS------FVYGRIVLLGDAAHATTPNMGQGAGQAMEDAIV---L 300

                        250       260
                 ....*....|....*....|..
gi 564381909 264 MDKFNN-DLSVCLPEFSRFRIP 284
Cdd:PRK06753 301 ANCLNAyDFEKALQRYDKIRVK 322
PRK08849 PRK08849
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 229-286 2.25e-07

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 181564 [Multi-domain]  Cd Length: 384  Bit Score: 52.47  E-value: 2.25e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564381909 229 KSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKfNNDLSVCLPE-FSRFRIPDD 286
Cdd:PRK08849 278 KNNCVLLGDAAHTINPLAGQGVNLGFKDVDVLLAETEK-QGVLNDASFArYERRRRPDN 335
PRK06126 PRK06126
hypothetical protein; Provisional
 51-256 9.18e-07

hypothetical protein; Provisional


Pssm-ID: 235704 [Multi-domain]  Cd Length: 545  Bit Score: 51.15  E-value: 9.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  51 LLTAVESYPNAKVHFGHKLSKCCP-EEGILTM---LGPNKvPRDITCDLIVGCDGAYSTVRAHL---------------- 110
Cdd:PRK06126 132 LLEHAAAQPGVTLRYGHRLTDFEQdADGVTATvedLDGGE-SLTIRADYLVGCDGARSAVRRSLgisyegtsglqrdlsi 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909 111 -MKKPRFdysQQYIPH--GYMELTI-PPKNGEYAmepnclHIWPRNAFMMIALPnmdksftctlfmsFEEFEKLPTHSDV 186
Cdd:PRK06126 211 yIRAPGL---AALVGHdpAWMYWLFnPDRRGVLV------AIDGRDEWLFHQLR-------------GGEDEFTIDDVDA 268

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564381909 187 LDFFQKnfpdaipLMGEQAlmrDFFLLPAQPMISVK-CSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFED 256
Cdd:PRK06126 269 RAFVRR-------GVGEDI---DYEVLSVVPWTGRRlVADSYRRGRVFLAGDAAHLFTPTGGYGMNTGIGD 329
PRK06185 PRK06185
FAD-dependent oxidoreductase;
51-251 4.70e-06

FAD-dependent oxidoreductase;


Pssm-ID: 235729 [Multi-domain]  Cd Length: 407  Bit Score: 48.70  E-value: 4.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  51 LLTAVESYPNAKVHFGHKLSKCCPEEGI---LTMLGPNKvPRDITCDLIVGCDGAYSTVR--AHLmkKPR-----FDYSq 120
Cdd:PRK06185 114 LAEEASAYPNFTLRMGAEVTGLIEEGGRvtgVRARTPDG-PGEIRADLVVGADGRHSRVRalAGL--EVRefgapMDVL- 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909 121 qyiphgYMELTIPPKNGEYAMEpnclHIWPRNafMMIALPNMDKsFTCTLFMSFEEFEKLptHSDVLDFFQKNFPDAIPL 200
Cdd:PRK06185 190 ------WFRLPREPDDPESLMG----RFGPGQ--GLIMIDRGDY-WQCGYVIPKGGYAAL--RAAGLEAFRERVAELAPE 254

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564381909 201 MGEQAL----MRDFFLLpaqpmiSVKCSpfHLK--SR--CVLMGDAAHAIVPFFGQGMN 251
Cdd:PRK06185 255 LADRVAelksWDDVKLL------DVRVD--RLRrwHRpgLLCIGDAAHAMSPVGGVGIN 305
PRK08850 PRK08850
2-octaprenyl-6-methoxyphenol hydroxylase; Validated
 89-256 3.53e-05

2-octaprenyl-6-methoxyphenol hydroxylase; Validated


Pssm-ID: 236341 [Multi-domain]  Cd Length: 405  Bit Score: 45.92  E-value: 3.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  89 RDITCDLIVGCDGAYSTVRaHLMKKP--RFDYSQQYI--------PHGYMELTIPPKNGEYAM----EPN-CLHIWPRNA 153
Cdd:PRK08850 153 QALTAKLVVGADGANSWLR-RQMDIPltHWDYGHSALvanvrtvdPHNSVARQIFTPQGPLAFlpmsEPNmSSIVWSTEP 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909 154 FMMIALPNMDKS-FTCTLFMSFEEfeKLPTHSDVLDFFqknfpdAIPLMGEQAlmRDFfllpaqpmisvkcspfhLKSRC 232
Cdd:PRK08850 232 LRAEALLAMSDEqFNKALTAEFDN--RLGLCEVVGERQ------AFPLKMRYA--RDF-----------------VRERV 284

                        170       180
                 ....*....|....*....|....
gi 564381909 233 VLMGDAAHAIVPFFGQGMNAGFED 256
Cdd:PRK08850 285 ALVGDAAHTIHPLAGQGVNLGLLD 308
PRK07608 PRK07608
UbiH/UbiF family hydroxylase;
229-256 3.70e-05

UbiH/UbiF family hydroxylase;


Pssm-ID: 181057 [Multi-domain]  Cd Length: 388  Bit Score: 45.72  E-value: 3.70e-05
                         10        20
                 ....*....|....*....|....*...
gi 564381909 229 KSRCVLMGDAAHAIVPFFGQGMNAGFED 256
Cdd:PRK07608 279 APRVALVGDAAHLIHPLAGQGMNLGLRD 306
PRK07045 PRK07045
putative monooxygenase; Reviewed
 229-289 6.53e-05

putative monooxygenase; Reviewed


Pssm-ID: 136171 [Multi-domain]  Cd Length: 388  Bit Score: 44.90  E-value: 6.53e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564381909 229 KSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNND---LSVCLPEFSRFRIPDDHAI 289
Cdd:PRK07045 284 KRNVVLLGDAAHSIHPITGQGMNLAIEDAGELGACLDLHLSGqiaLADALERFERIRRPVNEAV 347
PRK08013 PRK08013
oxidoreductase; Provisional
 231-256 1.62e-04

oxidoreductase; Provisional


Pssm-ID: 236139 [Multi-domain]  Cd Length: 400  Bit Score: 43.50  E-value: 1.62e-04
                         10        20
                 ....*....|....*....|....*.
gi 564381909 231 RCVLMGDAAHAIVPFFGQGMNAGFED 256
Cdd:PRK08013 283 RLALVGDAAHTIHPLAGQGVNLGFMD 308
PRK05714 PRK05714
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 234-289 1.80e-04

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 168201 [Multi-domain]  Cd Length: 405  Bit Score: 43.66  E-value: 1.80e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564381909 234 LMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNN------DLSVcLPEFSRFRIPDDHAI 289
Cdd:PRK05714 289 LIGDAAHTIHPLAGQGVNLGFLDAAVLAEVLLHAAErgerlaDVRV-LSRFERRRMPHNLAL 349
PRK06847 PRK06847
hypothetical protein; Provisional
 94-284 4.41e-04

hypothetical protein; Provisional


Pssm-ID: 235874 [Multi-domain]  Cd Length: 375  Bit Score: 42.17  E-value: 4.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909  94 DLIVGCDGAYSTVRAHLM---KKPRF----------------DYSQQYIP-------------HGYMELTIPPKNGEYaM 141
Cdd:PRK06847 153 DLVVGADGLYSKVRSLVFpdePEPEYtgqgvwravlprpaevDRSLMYLGpttkagvvplsedLMYLFVTEPRPDNPR-I 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564381909 142 EPnclHIWPRnafmmiALPNMDKSFTctlfmsfeefeklpthSDVLDFFQKNFPDAiplmgEQALMRDF--FLLPAqpmi 219
Cdd:PRK06847 232 EP---DTLAA------LLRELLAPFG----------------GPVLQELREQITDD-----AQVVYRPLetLLVPA---- 277

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564381909 220 svkcsPFHlKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKfNNDLSVCLPEFSRFRIP 284
Cdd:PRK06847 278 -----PWH-RGRVVLIGDAAHATTPHLAQGAGMAIEDAIVLAEELAR-HDSLEAALQAYYARRWE 335
PRK07333 PRK07333
ubiquinone biosynthesis hydroxylase;
229-256 5.73e-04

ubiquinone biosynthesis hydroxylase;


Pssm-ID: 180935 [Multi-domain]  Cd Length: 403  Bit Score: 41.89  E-value: 5.73e-04
                         10        20
                 ....*....|....*....|....*...
gi 564381909 229 KSRCVLMGDAAHAIVPFFGQGMNAGFED 256
Cdd:PRK07333 279 APRFALVGDAAHGIHPIAGQGLNLGLKD 306
PRK07538 PRK07538
hypothetical protein; Provisional
 37-110 7.34e-04

hypothetical protein; Provisional


Pssm-ID: 236046 [Multi-domain]  Cd Length: 413  Bit Score: 41.81  E-value: 7.34e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564381909  37 QYilSISREKLNKDLLTAV-ESYPNAKVHFGHKLSKCCP-EEGILTMLGPN--KVPRDITCDLIVGCDGAYSTVRAHL 110
Cdd:PRK07538  96 QY--SIHRGELQMLLLDAVrERLGPDAVRTGHRVVGFEQdADVTVVFLGDRagGDLVSVRGDVLIGADGIHSAVRAQL 171
PRK06475 PRK06475
FAD-binding protein;
217-284 1.06e-03

FAD-binding protein;


Pssm-ID: 180582 [Multi-domain]  Cd Length: 400  Bit Score: 40.96  E-value: 1.06e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564381909 217 PMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDkfNNDLSVCLPEFSRFRIP 284
Cdd:PRK06475 279 PLFEMADAQFVGPDRTIFLGDASHAVTPFAAQGAAMAIEDAAALAEALD--SDDQSAGLKRFDSVRKE 344
ubiF PRK08020
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed
 233-265 1.75e-03

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed


Pssm-ID: 181199 [Multi-domain]  Cd Length: 391  Bit Score: 40.35  E-value: 1.75e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 564381909 233 VLMGDAAHAIVPFFGQGMNAGFEDClvfDELMD 265
Cdd:PRK08020 284 ALVGDAAHTINPLAGQGVNLGYRDV---DALLD 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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