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Conserved domains on  [gi|564377930|ref|XP_006248826|]
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volume-regulated anion channel subunit LRRC8E isoform X1 [Rattus norvegicus]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-330 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 559.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930    1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPSHESRENSSEAPCQQLLPQGI--- 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPtqs 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930   78 -----SEQIGGLRELSGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISI 152
Cdd:pfam12534  81 aptvsSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930  153 LGKCFDSPWTTRALSEVSGENHKGPAAGRATVTTVTTVGTGTGKVGEGE------KEKVLIEPEKVVTE-PPAVTLLDKK 225
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKVSSSSSLSSSDEsapltrTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930  226 EGEQAKALFEKVKKFRVHVEEGDILYSMYIRQTVLKVCKFFAILVYNLVYVEKISFLVACRVETSEITGYASFCCNHTKA 305
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 564377930  306 HLFSKLAFCYISFVCVYGITCLYTL 330
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
562-764 1.47e-36

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 142.77  E-value: 1.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 562 LSLHNDGARLLALNSLKKLAVLRELELVACGleriphAIFSLGALQELDLKDNHLRSIEEILSfqHCRKLVILRLWHNQI 641
Cdd:COG4886   77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELA--NLTNLKELDLSNNQL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 642 AYVPEHVRKLRSLEQLYLSHNKLETLPAQLGQCFGLRLLDVSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCH 721
Cdd:COG4886  149 TDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLT 228

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 564377930 722 KLRTLLLGYNHLTQFsPHVAALQALSRLELKGNRLEALPEELG 764
Cdd:COG4886  229 NLETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-330 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 559.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930    1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPSHESRENSSEAPCQQLLPQGI--- 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPtqs 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930   78 -----SEQIGGLRELSGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISI 152
Cdd:pfam12534  81 aptvsSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930  153 LGKCFDSPWTTRALSEVSGENHKGPAAGRATVTTVTTVGTGTGKVGEGE------KEKVLIEPEKVVTE-PPAVTLLDKK 225
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKVSSSSSLSSSDEsapltrTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930  226 EGEQAKALFEKVKKFRVHVEEGDILYSMYIRQTVLKVCKFFAILVYNLVYVEKISFLVACRVETSEITGYASFCCNHTKA 305
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 564377930  306 HLFSKLAFCYISFVCVYGITCLYTL 330
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
562-764 1.47e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 142.77  E-value: 1.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 562 LSLHNDGARLLALNSLKKLAVLRELELVACGleriphAIFSLGALQELDLKDNHLRSIEEILSfqHCRKLVILRLWHNQI 641
Cdd:COG4886   77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELA--NLTNLKELDLSNNQL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 642 AYVPEHVRKLRSLEQLYLSHNKLETLPAQLGQCFGLRLLDVSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCH 721
Cdd:COG4886  149 TDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLT 228

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 564377930 722 KLRTLLLGYNHLTQFsPHVAALQALSRLELKGNRLEALPEELG 764
Cdd:COG4886  229 NLETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 606-754 6.37e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.52  E-value: 6.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 606 LQELDLKDNHLRSIEeilSFQHCRKLVILRLWHNQIAYVpEHVRKLRSLEQLYLSHNKLETLpAQLGQCFGLRLLDVSHN 685
Cdd:cd21340   26 LKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 686 glrSLPPE----------LGLLQSLQHLALSYNALESLpDELFFCHKLRTLLLGYNHLTQFS---PHVAALQALSRLELK 752
Cdd:cd21340  101 ---RLPPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLT 176


                 ..
gi 564377930 753 GN 754
Cdd:cd21340  177 GN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
585-763 1.82e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 80.51  E-value: 1.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 585 ELELVACGLERIPHAI--------------FSL-----GALQELDLKDNHLRSIEEILSfqhcRKLVILRLWHNQIAYVP 645
Cdd:PRK15370 182 ELRLKILGLTTIPACIpeqittlildnnelKSLpenlqGNIKTLYANSNQLTSIPATLP----DTIQEMELSINRITELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 646 EHVRKlrSLEQLYLSHNKLETLPAQLGQcfGLRLLDVSHNGLRSLPPELGllQSLQHLALSYNALESLPDELffCHKLRT 725
Cdd:PRK15370 258 ERLPS--ALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETL--PPGLKT 329

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 564377930 726 LLLGYNHLTQFSPHVAAlqALSRLELKGNRLEALPEEL 763
Cdd:PRK15370 330 LEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETL 365
LRR_8 pfam13855
Leucine rich repeat;
676-733 8.74e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 8.74e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930  676 GLRLLDVSHNGLRSLPPELGL-LQSLQHLALSYNALESLPDELFFC-HKLRTLLLGYNHL 733
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-330 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 559.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930    1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPSHESRENSSEAPCQQLLPQGI--- 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPtqs 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930   78 -----SEQIGGLRELSGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISI 152
Cdd:pfam12534  81 aptvsSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930  153 LGKCFDSPWTTRALSEVSGENHKGPAAGRATVTTVTTVGTGTGKVGEGE------KEKVLIEPEKVVTE-PPAVTLLDKK 225
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKVSSSSSLSSSDEsapltrTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930  226 EGEQAKALFEKVKKFRVHVEEGDILYSMYIRQTVLKVCKFFAILVYNLVYVEKISFLVACRVETSEITGYASFCCNHTKA 305
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 564377930  306 HLFSKLAFCYISFVCVYGITCLYTL 330
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
562-764 1.47e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 142.77  E-value: 1.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 562 LSLHNDGARLLALNSLKKLAVLRELELVACGleriphAIFSLGALQELDLKDNHLRSIEEILSfqHCRKLVILRLWHNQI 641
Cdd:COG4886   77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELA--NLTNLKELDLSNNQL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 642 AYVPEHVRKLRSLEQLYLSHNKLETLPAQLGQCFGLRLLDVSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCH 721
Cdd:COG4886  149 TDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLT 228

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 564377930 722 KLRTLLLGYNHLTQFsPHVAALQALSRLELKGNRLEALPEELG 764
Cdd:COG4886  229 NLETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
508-771 5.21e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.45  E-value: 5.21e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 508 LEELHLEGLFPPEMARGATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLLALNSLKKLAVLRELE 587
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 588 LVACGLerIPHAIFSLGALQELDLKDNhlrsieeiLSFQHCRKLVILRLWHNQIAYVPEHVRKLRSLEQLYLSHNKLETL 667
Cdd:COG4886   82 LSLLLL--GLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 668 PAQLGQCFGLRLLDVSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQFSPHVAALQALS 747
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLE 231

                        250       260
                 ....*....|....*....|....
gi 564377930 748 RLELKGNRLEALPeELGDCKGLKK 771
Cdd:COG4886  232 TLDLSNNQLTDLP-ELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
504-763 1.63e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.88  E-value: 1.63e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 504 GLRGLEELHLEGLfppemargatlESLRELKQLKVLSLRSNA-GKVPASVTDVAgHLQRLSLHNDgaRLLAL-NSLKKLA 581
Cdd:COG4886   94 DLTNLTELDLSGN-----------EELSNLTNLESLDLSGNQlTDLPEELANLT-NLKELDLSNN--QLTDLpEPLGNLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 582 VLRELELVACGLERIPHAIFSLGALQELDLKDNHLRSIEEILSfqHCRKLVILRLWHNQIAYVPEHVRKLRSLEQLYLSH 661
Cdd:COG4886  160 NLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLG--NLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSN 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 662 NKLETLPaQLGQCFGLRLLDVSHNGLRSLPPELGLlQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQFSPHVA 741
Cdd:COG4886  238 NQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        250       260
                 ....*....|....*....|..
gi 564377930 742 ALQALSRLELKGNRLEALPEEL 763
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
350-765 1.82e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 1.82e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 350 TGMNDIPDVRNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPDKLRQKLQRNARGRLELSLCMLPGLP 429
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 430 DTVFELSEVEALrleaicDISFPPGLSQLVNLQELSLLHSparlpfssqiflrdrlkvicvkfeELREVPLWVFGLRGLE 509
Cdd:COG4886   90 TDLGDLTNLTEL------DLSGNEELSNLTNLESLDLSGN------------------------QLTDLPEELANLTNLK 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 510 ELHLEG----LFPpemargatlESLRELKQLKVLSLRSNA-GKVPASVTDVAgHLQRLSLHNDgaRLLAL-NSLKKLAVL 583
Cdd:COG4886  140 ELDLSNnqltDLP---------EPLGNLTNLKSLDLSNNQlTDLPEELGNLT-NLKELDLSNN--QITDLpEPLGNLTNL 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 584 RELELVACGLERIPHAIFSLGALQELDLKDNHLRSIEEILSFQhcrKLVILRLWHNQIAYVPEhVRKLRSLEQLYLSHNK 663
Cdd:COG4886  208 EELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLT---NLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQ 283

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 664 LETLPAQLGQCFGLRLLDVSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQFSPHVAAL 743
Cdd:COG4886  284 LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363

                        410       420
                 ....*....|....*....|..
gi 564377930 744 QALSRLELKGNRLEALPEELGD 765
Cdd:COG4886  364 TLLLTLGLLGLLEATLLTLALL 385
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 606-754 6.37e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.52  E-value: 6.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 606 LQELDLKDNHLRSIEeilSFQHCRKLVILRLWHNQIAYVpEHVRKLRSLEQLYLSHNKLETLpAQLGQCFGLRLLDVSHN 685
Cdd:cd21340   26 LKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 686 glrSLPPE----------LGLLQSLQHLALSYNALESLpDELFFCHKLRTLLLGYNHLTQFS---PHVAALQALSRLELK 752
Cdd:cd21340  101 ---RLPPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLT 176


                 ..
gi 564377930 753 GN 754
Cdd:cd21340  177 GN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
585-763 1.82e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 80.51  E-value: 1.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 585 ELELVACGLERIPHAI--------------FSL-----GALQELDLKDNHLRSIEEILSfqhcRKLVILRLWHNQIAYVP 645
Cdd:PRK15370 182 ELRLKILGLTTIPACIpeqittlildnnelKSLpenlqGNIKTLYANSNQLTSIPATLP----DTIQEMELSINRITELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 646 EHVRKlrSLEQLYLSHNKLETLPAQLGQcfGLRLLDVSHNGLRSLPPELGllQSLQHLALSYNALESLPDELffCHKLRT 725
Cdd:PRK15370 258 ERLPS--ALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETL--PPGLKT 329

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 564377930 726 LLLGYNHLTQFSPHVAAlqALSRLELKGNRLEALPEEL 763
Cdd:PRK15370 330 LEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETL 365
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 450-769 8.93e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 75.27  E-value: 8.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 450 SFPPGLSQLVNLQELSLLHSPARLPFSSQIFlrDRLKVICVKFEELR---EVPLWVFGLRGLEELHLeglFPPEMArGAT 526
Cdd:PLN00113 251 PIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSlsgEIPELVIQLQNLEILHL---FSNNFT-GKI 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 527 LESLRELKQLKVLSLRSN--AGKVPASvtdvaghlqrLSLHNDGARL-LALNSLKKlavlrelelvacgleRIPHAIFSL 603
Cdd:PLN00113 325 PVALTSLPRLQVLQLWSNkfSGEIPKN----------LGKHNNLTVLdLSTNNLTG---------------EIPEGLCSS 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 604 GALQELDLKDNHLRSiEEILSFQHCRKLVILRLWHNQIA-YVPEHVRKLR------------------------SLEQLY 658
Cdd:PLN00113 380 GNLFKLILFSNSLEG-EIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPlvyfldisnnnlqgrinsrkwdmpSLQMLS 458

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 659 LSHNKLEtlpAQLGQCFG---LRLLDVSHNGLR-SLPPELGLLQSLQHLALSYNALES-LPDELFFCHKLRTLLLGYNHL 733
Cdd:PLN00113 459 LARNKFF---GGLPDSFGskrLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQL 535

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 564377930 734 T-QFSPHVAALQALSRLELKGNRLEA-LPEELGDCKGL 769
Cdd:PLN00113 536 SgQIPASFSEMPVLSQLDLSQNQLSGeIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 529-756 1.75e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 1.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 529 SLRELKQLKVLSLRSN--AGKVPASVtdvaGHLQRL------------SLHNDGARLLALN---------------SLKK 579
Cdd:PLN00113 183 SLTNLTSLEFLTLASNqlVGQIPREL----GQMKSLkwiylgynnlsgEIPYEIGGLTSLNhldlvynnltgpipsSLGN 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 580 LAVLRELELVACGLE-RIPHAIFSLGALQELDLKDNHLR-SIEEILSfqHCRKLVILRLWHNQI-AYVPEHVRKLRSLEQ 656
Cdd:PLN00113 259 LKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVI--QLQNLEILHLFSNNFtGKIPVALTSLPRLQV 336

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 657 LYLSHNKLE-TLPAQLGQCFGLRLLDVSHNGLRSLPPElGLLQS--LQHLALSYNALES-LPDELFFCHKLRTLLLGYNH 732
Cdd:PLN00113 337 LQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPE-GLCSSgnLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNS 415

                        250       260
                 ....*....|....*....|....*
gi 564377930 733 LT-QFSPHVAALQALSRLELKGNRL 756
Cdd:PLN00113 416 FSgELPSEFTKLPLVYFLDISNNNL 440
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 602-770 3.04e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.10  E-value: 3.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 602 SLGALQELDLKDNHLRS--IEEILSFQhcrKLVILRLWHNQI-AYVPEHVRKLRSLEQLYLSHNKLE-TLPAQLGQCFGL 677
Cdd:PLN00113 138 SIPNLETLDLSNNMLSGeiPNDIGSFS---SLKVLDLGGNVLvGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSL 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 678 RLLDVSHNGLR-SLPPELGLLQSLQHLALSYNALE-SLPDELFFCHKLRTLLLGYNHLT-QFSPHVAALQALSRLELKGN 754
Cdd:PLN00113 215 KWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDN 294

                        170
                 ....*....|....*..
gi 564377930 755 RLEA-LPEELGDCKGLK 770
Cdd:PLN00113 295 SLSGeIPELVIQLQNLE 311
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
630-789 1.14e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.02  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 630 KLVILRLWHNQIAYVPEHVRKlrSLEQLYLSHNKLETLPAQLGQCfgLRLLDVSHNGLRSLPPELGllQSLQHLALSYNA 709
Cdd:PRK15370 200 QITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPATLPDT--IQEMELSINRITELPERLP--SALQSLDLFHNK 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 710 LESLPDELffCHKLRTLLLGYNHLTQFSPHVAAlqALSRLELKGNRLEALPEELGdcKGLKksgLLVED-----TLYEGL 784
Cdd:PRK15370 274 ISCLPENL--PEELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP--PGLK---TLEAGenaltSLPASL 344


                 ....*
gi 564377930 785 PAEVR 789
Cdd:PRK15370 345 PPELQ 349
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 595-770 2.24e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 2.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 595 RIPHAIFSLGALQELDLKDNHLRSIEEILSFQHCRKLVILRLWHNQIA-YVPEHvrKLRSLEQLYLSHNKLE-TLPAQLG 672
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRG--SIPNLETLDLSNNMLSgEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 673 QCFGLRLLDVSHNGLRS-LPPELGLLQSLQHLALSYNALE-SLPDELFFCHKLRTLLLGYNHLTQFSPH-VAALQALSRL 749
Cdd:PLN00113 162 SFSSLKVLDLGGNVLVGkIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSGEIPYeIGGLTSLNHL 241

                        170       180
                 ....*....|....*....|..
gi 564377930 750 ELKGNRLEA-LPEELGDCKGLK 770
Cdd:PLN00113 242 DLVYNNLTGpIPSSLGNLKNLQ 263
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 536-771 2.50e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.55  E-value: 2.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 536 LKVLSLRSNA--GKVPASVTDVAGhLQRLSLhndgarllALNSL-----KKLAVLRELELVACGLE----RIPHAIFSLG 604
Cdd:PLN00113 166 LKVLDLGGNVlvGKIPNSLTNLTS-LEFLTL--------ASNQLvgqipRELGQMKSLKWIYLGYNnlsgEIPYEIGGLT 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 605 ALQELDLKDNHLrsIEEI-LSFQHCRKLVILRLWHNQIA-YVPEHVRKLRSLEQLYLSHNKLE-TLPAQLGQCFGLRLLD 681
Cdd:PLN00113 237 SLNHLDLVYNNL--TGPIpSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILH 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 682 VSHNGLR-SLPPELGLLQSLQHLALSYNALE-SLPDELFFCHKLRTLLLGYNHLTQFSPH-VAALQALSRLELKGNRLEA 758
Cdd:PLN00113 315 LFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEgLCSSGNLFKLILFSNSLEG 394

                        250
                 ....*....|....
gi 564377930 759 -LPEELGDCKGLKK 771
Cdd:PLN00113 395 eIPKSLGACRSLRR 408
LRR_8 pfam13855
Leucine rich repeat;
676-733 8.74e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 8.74e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930  676 GLRLLDVSHNGLRSLPPELGL-LQSLQHLALSYNALESLPDELFFC-HKLRTLLLGYNHL 733
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 479-756 1.51e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 54.41  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 479 IFLRDRLKVICVKFEELREVPLWvfglrglEELHLEGLFPPEMAR--GATLESLRELKQLKVLSLRSNAGKVPASVTDVa 556
Cdd:COG5238   84 AFPTQLLVVDWEGAEEVSPVALA-------ETATAVATPPPDLRRimAKTLEDSLILYLALPRRINLIQVLKDPLGGNA- 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 557 ghlQRLSLHNDGARLLALNSLKKLAVLRELELVAC--------GLERIPHAIFSLGALQELDLKDNHL--RSIEEILS-F 625
Cdd:COG5238  156 ---VHLLGLAARLGLLAAISMAKALQNNSVETVYLgcnqigdeGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaL 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 626 QHCRKLVILRLWHNQI-----AYVPEHVRKLRSLEQLYLSHNKletlpaqlgqcfglrlldVSHNGLRSLPPELGLLQSL 700
Cdd:COG5238  233 KGNKSLTTLDLSNNQIgdegvIALAEALKNNTTVETLYLSGNQ------------------IGAEGAIALAKALQGNTTL 294

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564377930 701 QHLALSYNAL-----ESLPDELFFCHKLRTLLLGYNHLTQ--FSPHVAALQA---LSRLELKGNRL 756
Cdd:COG5238  295 TSLDLSVNRIgdegaIALAEGLQGNKTLHTLNLAYNGIGAqgAIALAKALQEnttLHSLDLSDNQI 360
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 596-692 4.95e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.70  E-value: 4.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 596 IPHAIFSLGALQELDLKDNHLRS-IEEILSfqHCRKLVILRLWHNQIA-YVPEHVRKLRSLEQLYLSHNKLE-TLPAQLG 672
Cdd:PLN00113 491 VPRKLGSLSELMQLKLSENKLSGeIPDELS--SCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLG 568

                         90       100
                 ....*....|....*....|.
gi 564377930 673 QCFGLRLLDVSHNGLR-SLPP 692
Cdd:PLN00113 569 NVESLVQVNISHNHLHgSLPS 589
PLN03150 PLN03150
hypothetical protein; Provisional
 643-710 6.20e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.90  E-value: 6.20e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 643 YVPEHVRKLRSLEQLYLSHNKLE-TLPAQLGQCFGLRLLDVSHNGLR-SLPPELGLLQSLQHLALSYNAL 710
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
527-717 1.04e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.39  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 527 LESLRELKQ--LKVLSLRSNA-GKVPASVTDVAGHLQrlslhndgarlLALNSLKKL-----AVLRELELVACGLERIPH 598
Cdd:PRK15370 211 LKSLPENLQgnIKTLYANSNQlTSIPATLPDTIQEME-----------LSINRITELperlpSALQSLDLFHNKISCLPE 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 599 AIFSlgALQELDLKDNHLRSIEEILSfqhcRKLVILRLWHNQIAYVPEHVRKlrSLEQLYLSHNKLETLPAQLGQcfGLR 678
Cdd:PRK15370 280 NLPE--ELRYLSVYDNSIRTLPAHLP----SGITHLNVQSNSLTALPETLPP--GLKTLEAGENALTSLPASLPP--ELQ 349

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564377930 679 LLDVSHNGL----RSLPPEL---------------GLLQSLQHLALSYNALESLPDEL 717
Cdd:PRK15370 350 VLDVSKNQItvlpETLPPTIttldvsrnaltnlpeNLPAALQIMQASRNNLVRLPESL 407
LRR_8 pfam13855
Leucine rich repeat;
698-756 1.56e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.56e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564377930  698 QSLQHLALSYNALESLPDELFF-CHKLRTLLLGYNHLTQFSPHV-AALQALSRLELKGNRL 756
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
629-687 5.42e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 5.42e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564377930  629 RKLVILRLWHNQIAYVPEHV-RKLRSLEQLYLSHNKLETLPAQLGQCF-GLRLLDVSHNGL 687
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLpSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
583-641 2.53e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.53e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930  583 LRELELVACGLERI-PHAIFSLGALQELDLKDNHLRSIEEIlSFQHCRKLVILRLWHNQI 641
Cdd:pfam13855   3 LRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPG-AFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
656-788 2.16e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.69  E-value: 2.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 656 QLYLSHNKLETLPAQLGQCFGLRLLDvsHNGLRSLPPELGllQSLQHLALSYNALESLPDELffCHKLRTLLLGYNHLTQ 735
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTLILD--NNELKSLPENLQ--GNIKTLYANSNQLTSIPATL--PDTIQEMELSINRITE 255

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564377930 736 FSPHVAAlqALSRLELKGNRLEALPEELGDckGLKKsgLLVEDTLYEGLPAEV 788
Cdd:PRK15370 256 LPERLPS--ALQSLDLFHNKISCLPENLPE--ELRY--LSVYDNSIRTLPAHL 302
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
583-773 4.16e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.00  E-value: 4.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 583 LRELELVACGLERIPhaIFSLGALqELDLKDNHLRSIEEILSfqhcrKLVILRLWHNQIAYVPEHVRklrSLEQLYLSHN 662
Cdd:PRK15387 244 LRTLEVSGNQLTSLP--VLPPGLL-ELSIFSNPLTHLPALPS-----GLCKLWIFGNQLTSLPVLPP---GLQELSVSDN 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 663 KLETLPAQLGQcfgLRLLDVSHNGLRSLPPelgLLQSLQHLALSYNALESLP---DELFfchklrtLLLGYNHLTQFSPH 739
Cdd:PRK15387 313 QLASLPALPSE---LCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPtlpSELY-------KLWAYNNRLTSLPA 379

                        170       180       190
                 ....*....|....*....|....*....|....
gi 564377930 740 VAAlqALSRLELKGNRLEALPEELGDCKGLKKSG 773
Cdd:PRK15387 380 LPS--GLKELIVSGNRLTSLPVLPSELKELMVSG 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 527-667 9.43e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 9.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 527 LESLRELKQLKVLSLRSNagkvpaSVTDVAGhLQRLS----LHNDGARL-----LALN--SLKKLAV-LRELELVACGLE 594
Cdd:cd21340   61 IENLENLVNLKKLYLGGN------RISVVEG-LENLTnleeLHIENQRLppgekLTFDprSLAALSNsLRVLNISGNNID 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564377930 595 RIpHAIFSLGALQELDLKDNHLRSIEEIL-SFQHCRKLVILRLWHNQIAyvpeHVRKLRslEQLYLSHNKLETL 667
Cdd:cd21340  134 SL-EPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC----KKPKYR--DKIILASKSLEVL 200
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 526-790 1.00e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 526 TLESLRELKQLKVLSLRSNagkvpaSVTDVAGHLQRLSLHNDGARLLALNSLKKLA-VLRELELVACGLERIPhaifslg 604
Cdd:cd00116   15 ATELLPKLLCLQVLRLEGN------TLGEEAAKALASALRPQPSLKELCLSLNETGrIPRGLQSLLQGLTKGC------- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 605 ALQELDLKDNHLR--SIEEILSFQHCRKLVILRLWHNQIAyvPEHVRKL--------RSLEQLYLSHNKLETLPA-QLGQ 673
Cdd:cd00116   82 GLQELDLSDNALGpdGCGVLESLLRSSSLQELKLNNNGLG--DRGLRLLakglkdlpPALEKLVLGRNRLEGASCeALAK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 674 CF----GLRLLDVSHN-----GLRSLPPELGLLQSLQHLALSYNALESLPDElFFCH------KLRTLLLGYNHLTqfSP 738
Cdd:cd00116  160 ALranrDLKELNLANNgigdaGIRALAEGLKANCNLEVLDLNNNGLTDEGAS-ALAEtlaslkSLEVLNLGDNNLT--DA 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564377930 739 HVAAL--------QALSRLELKGNRLEA-----LPEELGDCKGLKKSGLLVEDTLYEG--LPAEVRE 790
Cdd:cd00116  237 GAAALasallspnISLLTLSLSCNDITDdgakdLAEVLAEKESLLELDLRGNKFGEEGaqLLAESLL 303
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 532-668 3.77e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 3.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 532 ELKQLKVLSLRSNA--GKVPASVTdvAGHLQRLSLHNDGARLLALNSLKKLAVLRELELVACGLE-RIPHAIFSLGALQE 608
Cdd:PLN00113 450 DMPSLQMLSLARNKffGGLPDSFG--SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVS 527

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564377930 609 LDLKDNHLrSIEEILSFQHCRKLVILRLWHNQIA-YVPEHVRKLRSLEQLYLSHNKLE-TLP 668
Cdd:PLN00113 528 LDLSHNQL-SGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLP 588
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 525-685 7.69e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 7.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 525 ATLESLRELKQLKVLSLRSNagkvpasvtdvaghlqrlSLHNDGARLLALnSLKKLAVLRELELVACGLER-----IPHA 599
Cdd:cd00116  156 ALAKALRANRDLKELNLANN------------------GIGDAGIRALAE-GLKANCNLEVLDLNNNGLTDegasaLAET 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377930 600 IFSLGALQELDLKDNHLRS--IEEILS--FQHCRKLVILRLWHNQIAY-----VPEHVRKLRSLEQLYLSHNKL----ET 666
Cdd:cd00116  217 LASLKSLEVLNLGDNNLTDagAAALASalLSPNISLLTLSLSCNDITDdgakdLAEVLAEKESLLELDLRGNKFgeegAQ 296

                        170       180
                 ....*....|....*....|.
gi 564377930 667 LPAQLGQCFG--LRLLDVSHN 685
Cdd:cd00116  297 LLAESLLEPGneLESLWVKDD 317
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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