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Conserved domains on  [gi|564377887|ref|XP_006248811|]
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stAR-related lipid transfer protein 13 isoform X6 [Rattus norvegicus]

Protein Classification

SRPBCC family protein( domain architecture ID 10138142)

SRPBCC (START/RHOalphaC/PITP/Bet v1/CoxG/CalC) family protein may have a deep hydrophobic ligand-binding pocket

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
START_STARD13-like cd08909
C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also ...
 801-1004 7.36e-149

C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD13 (also known as DLC-2, Arhgap37, and SDCCAG13) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subfamily also have a RhoGAP domain. The precise function of the START domain in this subgroup is unclear.


:

Pssm-ID: 176918  Cd Length: 205  Bit Score: 440.51  E-value: 7.36e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  801 ENGATFHTYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDED 880
Cdd:cd08909     2 EEGGTYQTYLESLIQNLQKEAKEKFKGWISCSSSDNTELAYKKVGDGNPLRLWKVSVEVEAPPSVVLNRVLRERHLWDED 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  881 FVQWKVVETLDRQTEIYQYVLNSMVPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLMGDVRAVVMDSQYLIEPCG 960
Cdd:cd08909    82 FLQWKVVETLDKQTEVYQYVLNCMAPHPSRDFVVLRSWRTDLPKGACSLVSVSVEHEEAPLLGGVRAVVLDSQYLIEPCG 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 564377887  961 SGKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVARIRNSFQPL 1004
Cdd:cd08909   162 SGKSRLTHICRVDLKGHSPEWYNKGFGHLCAAEAARIRNSFQPL 205
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 557-774 2.51e-137

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239840  Cd Length: 220  Bit Score: 411.04  E-value: 2.51e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  557 DKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVK 636
Cdd:cd04375     1 DKNVFGVPLLVNLQRTGQPLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDVADMLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  637 QFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAP 716
Cdd:cd04375    81 QYFRDLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLAP 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  717 SLFHLNLLKKE--SSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMITECNRLFEVPHEM 774
Cdd:cd04375   161 SLFHLNTSRREnsSPARRMQRKKSLGKPDQKELSENKAAHQCLAYMIEECNTLFMVPKEM 220
 
Name Accession Description Interval E-value
START_STARD13-like cd08909
C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also ...
 801-1004 7.36e-149

C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD13 (also known as DLC-2, Arhgap37, and SDCCAG13) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subfamily also have a RhoGAP domain. The precise function of the START domain in this subgroup is unclear.


Pssm-ID: 176918  Cd Length: 205  Bit Score: 440.51  E-value: 7.36e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  801 ENGATFHTYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDED 880
Cdd:cd08909     2 EEGGTYQTYLESLIQNLQKEAKEKFKGWISCSSSDNTELAYKKVGDGNPLRLWKVSVEVEAPPSVVLNRVLRERHLWDED 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  881 FVQWKVVETLDRQTEIYQYVLNSMVPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLMGDVRAVVMDSQYLIEPCG 960
Cdd:cd08909    82 FLQWKVVETLDKQTEVYQYVLNCMAPHPSRDFVVLRSWRTDLPKGACSLVSVSVEHEEAPLLGGVRAVVLDSQYLIEPCG 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 564377887  961 SGKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVARIRNSFQPL 1004
Cdd:cd08909   162 SGKSRLTHICRVDLKGHSPEWYNKGFGHLCAAEAARIRNSFQPL 205
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 557-774 2.51e-137

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 411.04  E-value: 2.51e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  557 DKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVK 636
Cdd:cd04375     1 DKNVFGVPLLVNLQRTGQPLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDVADMLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  637 QFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAP 716
Cdd:cd04375    81 QYFRDLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLAP 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  717 SLFHLNLLKKE--SSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMITECNRLFEVPHEM 774
Cdd:cd04375   161 SLFHLNTSRREnsSPARRMQRKKSLGKPDQKELSENKAAHQCLAYMIEECNTLFMVPKEM 220
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 574-720 2.36e-44

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 158.20  E-value: 2.36e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887    574 QPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPD-NVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLS 652
Cdd:smart00324    1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDpDLDLSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564377887    653 ETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLFH 720
Cdd:smart00324   81 EEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLR 148
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 577-720 8.42e-43

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 152.70  E-value: 8.42e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887   577 PQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVS-YEDQSAYDVADMVKQFFRDLPEPLFTNKLSETF 655
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLdLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564377887   656 LHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLFH 720
Cdd:pfam00620   81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLR 145
START smart00234
in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and ...
 813-996 2.10e-39

in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and phosphatidylcholine transfer protein


Pssm-ID: 214575  Cd Length: 205  Bit Score: 145.27  E-value: 2.10e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887    813 LVQGLQKEAKEKFKGWVTCSSPDNTDLAFKKV----GDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDEDFVQWKVVE 888
Cdd:smart00234    5 AAAELLKMAAASEEGWVLSSENENGDEVRSIFspgrKPGEAFRLVGVVPMVCADLVEELMDDLEYRPEWDKNVAKAETLE 84

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887    889 TLDRQTEIYQYVLNSMV-PHPSRDFVVLRTWKTDlPKGMCTLVSLSVEHEEA-QLMGDVRAVVMDSQYLIEPCGSGKSRL 966
Cdd:smart00234   85 VIDNGTVIYHYVSKFAAgPVSPRDFVFVRYWRED-EDGSYAVVDVSVTHPTSpPESGYVRAENLPSGLLIEPLGNGPSKV 163

                           170       180       190
                    ....*....|....*....|....*....|
gi 564377887    967 THICRIDLKGHSPEWYSKGFGHLCAAEVAR 996
Cdd:smart00234  164 TWVSHADLKGWLPHWLVRSLIKSGLAEFAK 193
START pfam01852
START domain;
808-998 4.20e-39

START domain;


Pssm-ID: 426476  Cd Length: 205  Bit Score: 144.47  E-value: 4.20e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887   808 TYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLAFKKV--GDGNPLKLWKASVEV-EAPPSVVLNRVLReRHLWDEDFVQW 884
Cdd:pfam01852    1 ELAEEAAQELLKLALSDEPGWVLLSSNENGDVVLQIVepDHGEASRASGVVPMVaALLVAELLKDMEY-RAQWDKDVRSA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887   885 KVVETLDRQTEIYQYVLNSMV--PHPSRDFVVLRTWKTDlPKGMCTLVSLSVEHEEA-QLMGDVRAVVMDSQYLIEPCGS 961
Cdd:pfam01852   80 ETLEVISSGGDLQYYVAALVApsPLSPRDFVFLRYWRRL-GGGVYVIVDRSVTHPQFpPSSGYVRAERLPSGYLIQPCGN 158

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 564377887   962 GKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVARIR 998
Cdd:pfam01852  159 GPSKVTWVSHADLKGWLPSWLLRSLYKSGMPEGAKTW 195
 
Name Accession Description Interval E-value
START_STARD13-like cd08909
C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also ...
 801-1004 7.36e-149

C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD13 (also known as DLC-2, Arhgap37, and SDCCAG13) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subfamily also have a RhoGAP domain. The precise function of the START domain in this subgroup is unclear.


Pssm-ID: 176918  Cd Length: 205  Bit Score: 440.51  E-value: 7.36e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  801 ENGATFHTYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDED 880
Cdd:cd08909     2 EEGGTYQTYLESLIQNLQKEAKEKFKGWISCSSSDNTELAYKKVGDGNPLRLWKVSVEVEAPPSVVLNRVLRERHLWDED 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  881 FVQWKVVETLDRQTEIYQYVLNSMVPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLMGDVRAVVMDSQYLIEPCG 960
Cdd:cd08909    82 FLQWKVVETLDKQTEVYQYVLNCMAPHPSRDFVVLRSWRTDLPKGACSLVSVSVEHEEAPLLGGVRAVVLDSQYLIEPCG 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 564377887  961 SGKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVARIRNSFQPL 1004
Cdd:cd08909   162 SGKSRLTHICRVDLKGHSPEWYNKGFGHLCAAEAARIRNSFQPL 205
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 557-774 2.51e-137

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 411.04  E-value: 2.51e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  557 DKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVK 636
Cdd:cd04375     1 DKNVFGVPLLVNLQRTGQPLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDVADMLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  637 QFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAP 716
Cdd:cd04375    81 QYFRDLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLAP 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  717 SLFHLNLLKKE--SSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMITECNRLFEVPHEM 774
Cdd:cd04375   161 SLFHLNTSRREnsSPARRMQRKKSLGKPDQKELSENKAAHQCLAYMIEECNTLFMVPKEM 220
START_RhoGAP cd08869
C-terminal lipid-binding START domain of mammalian STARD8, -12, -13 and related proteins, ...
 808-1004 8.80e-124

C-terminal lipid-binding START domain of mammalian STARD8, -12, -13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD8 (also known as deleted in liver cancer 3/DLC3, and Arhgap38), STARD12 (also known as DLC-1, Arhgap7, and p122-RhoGAP), and STARD13 (also known as DLC-2, Arhgap37, and SDCCAG13). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subfamily also have a RhoGAP domain. Some, including STARD12, -and -13, also have an N-terminal SAM (sterile alpha motif) domain; these have a SAM-RhoGAP-START domain organization. This subfamily is involved in cancer development. A large spectrum of cancers have dysregulated genes encoding these proteins. The precise function of the START domain in this subfamily is unclear.


Pssm-ID: 176878  Cd Length: 197  Bit Score: 374.72  E-value: 8.80e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  808 TYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDEDFVQWKVV 887
Cdd:cd08869     1 SYLERCVQDLLREARDKSKGWVSVSSSDHVELAFKKVDDGHPLRLWRASTEVEAPPEEVLQRILRERHLWDDDLLQWKVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  888 ETLDRQTEIYQYVLNSMVPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLMGDVRAVVMDSQYLIEPCGSGKSRLT 967
Cdd:cd08869    81 ETLDEDTEVYQYVTNSMAPHPTRDYVVLRTWRTDLPKGACVLVETSVEHTEPVPLGGVRAVVLASRYLIEPCGSGKSRVT 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 564377887  968 HICRIDLKGHSPEWYSKGFGHLCAAEVARIRNSFQPL 1004
Cdd:cd08869   161 HICRVDLRGRSPEWYNKVYGHLCARELLRIRDSFRQL 197
START_STARD8-like cd08907
C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also ...
 803-1004 1.64e-104

C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD8 (also known as deleted in liver cancer 3/DLC3, and Arhgap38) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subfamily also have a RhoGAP domain. The precise function of the START domain in this subgroup is unclear.


Pssm-ID: 176916  Cd Length: 205  Bit Score: 324.57  E-value: 1.64e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  803 GATFHTYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDEDFV 882
Cdd:cd08907     4 GVDLRAYLEDNVQCLLREASERFKGWHSAPGPDNTELACKKVGDGHPLRLWKVSTEVEAPPSVVLQRVLRERHLWDEDLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  883 QWKVVETLDRQTEIYQYVLNSMVPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLMGDVRAVVMDSQYLIEPCGSG 962
Cdd:cd08907    84 HSQVIEALENNTEVYHYVTDSMAPHPRRDFVVLRMWRSDLPRGGCLLVSQSVDHDNPQLEAGVRAVLLTSQYLIEPCGMG 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 564377887  963 KSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVARIRNSFQPL 1004
Cdd:cd08907   164 RSRLTHICRADLRGRSPDWYNKVFGHLCAMEVARIRDSFPTL 205
START_STARD12-like cd08908
C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also ...
 804-1001 4.07e-95

C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD12 (also known as DLC-1, Arhgap7, and p122-RhoGAP) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subgroup also have an N-terminal SAM (sterile alpha motif) domain and a RhoGAP domain, and have a SAM-RhoGAP-START domain organization. The precise function of the START domain in this subgroup is unclear.


Pssm-ID: 176917  Cd Length: 204  Bit Score: 299.62  E-value: 4.07e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  804 ATFHTYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDEDFVQ 883
Cdd:cd08908     5 ADYHHFLQDCVDGLFKEVKEKFKGWVSYSTSEQAELSYKKVSEGPPLRLWRTTIEVPAAPEEILKRLLKEQHLWDVDLLD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  884 WKVVETLDRQTEIYQYVLNSMVPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLMGdVRAVVMDSQYLIEPCGSGK 963
Cdd:cd08908    85 SKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNLPKGACALLATSVDHDRAPVAG-VRVNVLLSRYLIEPCGSGK 163

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 564377887  964 SRLTHICRIDLKGHSPEWYSKGFGHLCAAEVARIRNSF 1001
Cdd:cd08908   164 SKLTYMCRIDLRGHMPEWYTKSFGHLCAAEVVKIRDSF 201
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 574-720 2.36e-44

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 158.20  E-value: 2.36e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887    574 QPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPD-NVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLS 652
Cdd:smart00324    1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDpDLDLSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564377887    653 ETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLFH 720
Cdd:smart00324   81 EEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLR 148
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 577-720 8.42e-43

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 152.70  E-value: 8.42e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887   577 PQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVS-YEDQSAYDVADMVKQFFRDLPEPLFTNKLSETF 655
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLdLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564377887   656 LHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLFH 720
Cdd:pfam00620   81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLR 145
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 577-720 7.05e-42

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 150.92  E-value: 7.05e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  577 PQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFL 656
Cdd:cd00159     1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564377887  657 HIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLFH 720
Cdd:cd00159    81 ELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLR 144
START smart00234
in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and ...
 813-996 2.10e-39

in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and phosphatidylcholine transfer protein


Pssm-ID: 214575  Cd Length: 205  Bit Score: 145.27  E-value: 2.10e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887    813 LVQGLQKEAKEKFKGWVTCSSPDNTDLAFKKV----GDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDEDFVQWKVVE 888
Cdd:smart00234    5 AAAELLKMAAASEEGWVLSSENENGDEVRSIFspgrKPGEAFRLVGVVPMVCADLVEELMDDLEYRPEWDKNVAKAETLE 84

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887    889 TLDRQTEIYQYVLNSMV-PHPSRDFVVLRTWKTDlPKGMCTLVSLSVEHEEA-QLMGDVRAVVMDSQYLIEPCGSGKSRL 966
Cdd:smart00234   85 VIDNGTVIYHYVSKFAAgPVSPRDFVFVRYWRED-EDGSYAVVDVSVTHPTSpPESGYVRAENLPSGLLIEPLGNGPSKV 163

                           170       180       190
                    ....*....|....*....|....*....|
gi 564377887    967 THICRIDLKGHSPEWYSKGFGHLCAAEVAR 996
Cdd:smart00234  164 TWVSHADLKGWLPHWLVRSLIKSGLAEFAK 193
START pfam01852
START domain;
808-998 4.20e-39

START domain;


Pssm-ID: 426476  Cd Length: 205  Bit Score: 144.47  E-value: 4.20e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887   808 TYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLAFKKV--GDGNPLKLWKASVEV-EAPPSVVLNRVLReRHLWDEDFVQW 884
Cdd:pfam01852    1 ELAEEAAQELLKLALSDEPGWVLLSSNENGDVVLQIVepDHGEASRASGVVPMVaALLVAELLKDMEY-RAQWDKDVRSA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887   885 KVVETLDRQTEIYQYVLNSMV--PHPSRDFVVLRTWKTDlPKGMCTLVSLSVEHEEA-QLMGDVRAVVMDSQYLIEPCGS 961
Cdd:pfam01852   80 ETLEVISSGGDLQYYVAALVApsPLSPRDFVFLRYWRRL-GGGVYVIVDRSVTHPQFpPSSGYVRAERLPSGYLIQPCGN 158

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 564377887   962 GKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVARIR 998
Cdd:pfam01852  159 GPSKVTWVSHADLKGWLPSWLLRSLYKSGMPEGAKTW 195
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 560-779 8.30e-35

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 132.47  E-value: 8.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  560 VFGVPLIVHVQRTGQPLPQS-----IQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNEN--FPDNVSYEDQSAYDVA 632
Cdd:cd04391     1 LFGVPLSTLLERDQKKVPGSkvpliFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAkfYEGTFLWDQVKQHDAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  633 DMVKQFFRDLPEPLFTNKLSETFLHIyQYVP-KEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLA 711
Cdd:cd04391    81 SLLKLFIRELPQPLLTVEYLPAFYSV-QGLPsKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564377887  712 VCLAPSLFhlnllkkesSPRVIQKKYATGkpDQKDLNENLAAAQGLAHMITECNRLFEVPHEMVAQSR 779
Cdd:cd04391   160 MIMAPNLF---------PPRGKHSKDNES--LQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
START cd00177
Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins; This family ...
 819-1002 5.76e-34

Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins; This family includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and related domains, such as the START domain of the Arabidopsis homeobox protein GLABRA 2. The mammalian STARDs are grouped into 8 subfamilies. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some members of this family, specific lipids that bind in this pocket are known; these include cholesterol (STARD1/STARD3/ STARD4/STARD5), 25-hydroxycholesterol (STARD5), phosphatidylcholine (STARD2/ STARD7/STARD10), phosphatidylethanolamine (STARD10) and ceramides (STARD11). The START domain is found either alone or in association with other domains. Mammalian STARDs participate in the control of various cellular processes including lipid trafficking between intracellular compartments, lipid metabolism, and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer, genetic disorders, and autoimmune disease. The Arabidopsis homeobox protein GLABRA 2 suppresses root hair formation in hairless epidermal root cells.


Pssm-ID: 176851 [Multi-domain]  Cd Length: 193  Bit Score: 129.00  E-value: 5.76e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  819 KEAKEKFKGWVTCSSPDNTDLaFKKVGDGNPLKLWKASVEVEAPPSVVLNRV--LRERHLWDEDFVQWKVVETLDRQTEI 896
Cdd:cd00177     8 LELLEEPEGWKLVKEKDGVKI-YTKPYEDSGLKLLKAEGVIPASPEQVFELLmdIDLRKKWDKNFEEFEVIEEIDEHTDI 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  897 YQYVLNSMVPHPSRDFVVLRTWKtDLPKGMCTLVSLSVEHEEAQLMGD-VRAVVMDSQYLIEPCGSGKSRLTHICRIDLK 975
Cdd:cd00177    87 IYYKTKPPWPVSPRDFVYLRRRR-KLDDGTYVIVSKSVDHDSHPKEKGyVRAEIKLSGWIIEPLDPGKTKVTYVLQVDPK 165

                         170       180
                  ....*....|....*....|....*...
gi 564377887  976 GHSPEW-YSKGFGHLCAAEVARIRNSFQ 1002
Cdd:cd00177   166 GSIPKSlVNSAAKKQLASFLKDLRKAKK 193
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 561-718 1.84e-27

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 110.51  E-value: 1.84e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  561 FGVPL--IVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQM-NENFPDNV-SYEDqsAYDVADMVK 636
Cdd:cd04404     6 FGVSLqfLKEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKyNMGEPVDFdQYED--VHLPAVILK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  637 QFFRDLPEPLFTNKLSETFLHIyQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAP 716
Cdd:cd04404    84 TFLRELPEPLLTFDLYDDIVGF-LNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGP 162


                  ..
gi 564377887  717 SL 718
Cdd:cd04404   163 NL 164
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 576-774 6.55e-27

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 109.45  E-value: 6.55e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  576 LPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETF 655
Cdd:cd04376     9 VPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELYTAF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  656 LHIYQYVPKEQrLQAVQAAILLLADENREALQTLLCFLHDVV-----------NLVDENQMTPMNLAVCLAPSLFHlnll 724
Cdd:cd04376    89 IGTALLEPDEQ-LEALQLLIYLLPPCNCDTLHRLLKFLHTVAehaadsidedgQEVSGNKMTSLNLATIFGPNLLH---- 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 564377887  725 KKESSPRVIQKKYATgkpdqkdLNENLAAAQGLAHMITECNRLFEVPHEM 774
Cdd:cd04376   164 KQKSGEREFVQASLR-------IEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 560-722 9.30e-26

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 106.02  E-value: 9.30e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  560 VFGVPL----IVHVQRTGQpLPQSIQQALRYLRSNcLDQVGLFRKSGVKSRIHALRQMNENFPDNVSyedqSAY--DVAD 633
Cdd:cd04394     1 VFGVPLhslpHSTVPEYGN-VPKFLVDACTFLLDH-LSTEGLFRKSGSVVRQKELKAKLEGGEACLS----SALpcDVAG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  634 MVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVC 713
Cdd:cd04394    75 LLKQFFRELPEPLLPYDLHEALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVI 154


                  ....*....
gi 564377887  714 LAPSLFHLN 722
Cdd:cd04394   155 FAPNLFQSE 163
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 561-718 6.00e-25

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 102.90  E-value: 6.00e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  561 FGVPLiVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVKQFFR 640
Cdd:cd04377     1 FGVSL-SSLTSEDRSVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNLEDYPIHVITSVLKQWLR 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564377887  641 DLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSL 718
Cdd:cd04377    80 ELPEPLMTFELYENFLRAMELEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFAPCI 157
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 596-720 2.47e-24

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 101.23  E-value: 2.47e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  596 GLFRKSGVKSRIHALrqMNENFPDNVSYE----DQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAV 671
Cdd:cd04385    35 GIYRKNGKNSSVKKL--LEAFRKDARSVQlregEYTVHDVADVLKRFLRDLPDPLLTSELHAEWIEAAELENKDERIARY 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 564377887  672 QAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLFH 720
Cdd:cd04385   113 KELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQ 161
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 561-719 7.69e-24

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 100.17  E-value: 7.69e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  561 FGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYD-----VADMV 635
Cdd:cd04398     1 FGVPLEDLILREGDNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPLNVLLISPEDYEsdihsVASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  636 KQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLA 715
Cdd:cd04398    81 KLFFRELPEPLLTKALSREFIEAAKIEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLAIIWG 160


                  ....
gi 564377887  716 PSLF 719
Cdd:cd04398   161 PTLM 164
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 561-722 1.43e-22

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 96.21  E-value: 1.43e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  561 FGVPLIVHVQRTGqpLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALR-QMNENfpDNVSYEDQSAYDVADMVKQFF 639
Cdd:cd04402     2 FGQPLSNICEDDN--LPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKeKLNSG--VEVDLKAEPVLLLASVLKDFL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  640 RDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLF 719
Cdd:cd04402    78 RNIPGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLL 157


                  ...
gi 564377887  720 HLN 722
Cdd:cd04402   158 WPP 160
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 558-718 1.48e-22

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 96.76  E-value: 1.48e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  558 KAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRI----HALRQMNENFPDNVSYEDQSAydVAD 633
Cdd:cd04386     2 KPVFGTPLEEHLKRTGREIALPIEACVMCLLETGMNEEGLFRVGGGASKLkrlkAALDAGTFSLPLDEFYSDPHA--VAS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  634 MVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVC 713
Cdd:cd04386    80 ALKSYLRELPDPLLTYNLYEDWVQAANKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIV 159


                  ....*
gi 564377887  714 LAPSL 718
Cdd:cd04386   160 LAPNL 164
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 575-719 3.60e-22

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 95.06  E-value: 3.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  575 PLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSET 654
Cdd:cd04407    14 SVPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKLENYPIHAITGLLKQWLRELPEPLMTFAQYND 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564377887  655 FLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLF 719
Cdd:cd04407    94 FLRAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPCLL 158
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 560-721 8.90e-20

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 88.29  E-value: 8.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  560 VFGVPLiVHVQRTGQP---LPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNEN-FPDNVSYEDQSAyDVADMV 635
Cdd:cd04393     2 VFGVPL-QELQQAGQPengVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSgEEVDLSKEADVC-SAASLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  636 KQFFRDLPEPLFTNKLSETFLHIYQ-YVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCL 714
Cdd:cd04393    80 RLFLQELPEGLIPASLQIRLMQLYQdYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAVF 159


                  ....*..
gi 564377887  715 APSLFHL 721
Cdd:cd04393   160 GPDVFHV 166
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 573-771 9.29e-20

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 88.67  E-value: 9.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  573 GQPLPQS----IQQALRYLRSNcLDQVGLFRKSGVKSRIHALR-QMNENFPDNVSYEDQSAYDVADMVKQFFRDLPEPLF 647
Cdd:cd04392     2 GAPLTEEgiaqIYQLIEYLEKN-LRVEGLFRKPGNSARQQELRdLLNSGTDLDLESGGFHAHDCATVLKGFLGELPEPLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  648 TNKLSETFLHI---YQY--------VPKEQR-LQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLA 715
Cdd:cd04392    81 THAHYPAHLQIadlCQFdekgnktsAPDKERlLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 564377887  716 PSLfhlnLLKKESSPrviqkkyatgkpdqKDLNENLAA-AQGLAHMITECNRLFEVP 771
Cdd:cd04392   161 PHL----ICPRNLTP--------------EDLHENAQKlNSIVTFMIKHSQKLFKAP 199
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 561-720 1.28e-19

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 87.86  E-value: 1.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  561 FGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVSYeDQSAYD---VADMVKQ 637
Cdd:cd04383     3 FNGSLEEYIQDSGQAIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEDPLAD-DQNDHDinsVAGVLKL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  638 FFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPS 717
Cdd:cd04383    82 YFRGLENPLFPKERFEDLMSCVKLENPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGPT 161


                  ...
gi 564377887  718 LFH 720
Cdd:cd04383   162 LMP 164
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 561-720 5.85e-19

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 85.91  E-value: 5.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  561 FGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALR----QMNENFPDNVSYEDqsAYDVADMVK 636
Cdd:cd04403     1 FGCHLEALCQRENSTVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRfavdHDEKLDLDDSKWED--IHVITGALK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  637 QFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAP 716
Cdd:cd04403    79 LFFRELPEPLFPYSLFNDFVAAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGP 158


                  ....
gi 564377887  717 SLFH 720
Cdd:cd04403   159 TLLR 162
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 561-719 3.64e-18

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 83.27  E-value: 3.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  561 FGVPLIVHVQRTGqPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHAL-RQMNENFPDNVSYEDQSAYDVADMVKQFF 639
Cdd:cd04373     1 FGVPLANVVTSEK-PIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLqKQFDQDHNLDLVSKDFTVNAVAGALKSFF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  640 RDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLF 719
Cdd:cd04373    80 SELPDPLIPYSMHLELVEAAKINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWPTLM 159
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 580-718 7.73e-18

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 82.83  E-value: 7.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  580 IQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQM--NENFPDNVSYED-QSAYD---VADMVKQFFRDLPEPLFTNKLSE 653
Cdd:cd04374    32 VRKCIEAVETRGINEQGLYRVVGVNSKVQKLLSLglDPKTSTPGDVDLdNSEWEiktITSALKTYLRNLPEPLMTYELHN 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564377887  654 TFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSL 718
Cdd:cd04374   112 DFINAAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTL 176
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 561-718 8.56e-18

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 82.10  E-value: 8.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  561 FGVPLIVHVQRT----GQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENfPDNVSYEDQSAYDVADMVK 636
Cdd:cd04381     1 FGASLSLAVERSrchdGIDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNR-RESPNLEEYEPPTVASLLK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  637 QFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAP 716
Cdd:cd04381    80 QYLRELPEPLLTKELMPRFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIVLSP 159


                  ..
gi 564377887  717 SL 718
Cdd:cd04381   160 TV 161
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 592-718 9.34e-18

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 82.86  E-value: 9.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  592 LDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHI---YQYVPKEQR- 667
Cdd:cd04378    32 LGVQGIYRVSGSKARVEKLCQAFENGKDLVELSELSPHDISSVLKLFLRQLPEPLILFRLYNDFIALakeIQRDTEEDKa 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564377887  668 ----------LQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSL 718
Cdd:cd04378   112 pntpievnriIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVFGPTL 172
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 560-719 2.52e-16

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 78.31  E-value: 2.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  560 VFGVPLIVHVQRTGQPLPQSIQQALRYL-RSNCLDqvGLFRKSGVKSRIHALRQM--NENFPDNVSYE-DQSAYDVADMV 635
Cdd:cd04384     2 VFGCDLTEHLLNSGQDVPQVLKSCTEFIeKHGIVD--GIYRLSGIASNIQRLRHEfdSEQIPDLTKDVyIQDIHSVSSLC 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  636 KQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLA 715
Cdd:cd04384    80 KLYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWA 159


                  ....
gi 564377887  716 PSLF 719
Cdd:cd04384   160 PNLL 163
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 561-722 4.42e-15

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 75.09  E-value: 4.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  561 FGVPLIVHVQRTGQP-----------LPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVS-YEDQSA 628
Cdd:cd04397     1 FGVPLEILVEKFGADstlgvgpgklrIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVPdLSKENP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  629 YDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNL--VDE---N 703
Cdd:cd04397    81 VQLAALLKKFLRELPDPLLTFKLYRLWISSQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFshIDEetgS 160

                         170
                  ....*....|....*....
gi 564377887  704 QMTPMNLAVCLAPSLFHLN 722
Cdd:cd04397   161 KMDIHNLATVITPNILYSK 179
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 561-718 5.44e-14

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 72.15  E-value: 5.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  561 FGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVKQFFR 640
Cdd:cd04409     1 FGADFAQVAKKSPDGIPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSELSPHDISNVLKLYLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  641 DLPEPLFTNKLSETFLHI---YQYVPKEQRLQAVQA-----------AILL--------LADENREALQTLLCFLHDVVN 698
Cdd:cd04409    81 QLPEPLILFRLYNEFIGLakeSQHVNETQEAKKNSDkkwpnmctelnRILLkskdllrqLPAPNYNTLQFLIVHLHRVSE 160

                         170       180
                  ....*....|....*....|
gi 564377887  699 LVDENQMTPMNLAVCLAPSL 718
Cdd:cd04409   161 QAEENKMSASNLGIIFGPTL 180
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 560-718 8.79e-14

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 70.89  E-value: 8.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  560 VFGVPL-IVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYD---VADMV 635
Cdd:cd04395     1 TFGVPLdDCPPSSENPYVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGFDIDLQDPRWRDvnvVSSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  636 KQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLA 715
Cdd:cd04395    81 KSFFRKLPEPLFTNELYPDFIEANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFG 160


                  ...
gi 564377887  716 PSL 718
Cdd:cd04395   161 PTL 163
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 561-719 1.21e-13

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 70.41  E-value: 1.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  561 FGVPLiVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVKQFFR 640
Cdd:cd04406     1 FGVEL-SRLTSEDRSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDYNIHVIASVFKQWLR 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564377887  641 DLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLF 719
Cdd:cd04406    80 DLPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPCIL 158
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 561-719 1.77e-13

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 70.57  E-value: 1.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  561 FGVPLIVHVQRTGQPL--PQSIQQALRYLRSNCLDQVGLFRKSG---VKSRIHALRQMN--------ENFPD-NVsyedq 626
Cdd:cd04379     1 FGVPLSRLVEREGESRdvPIVLQKCVQEIERRGLDVIGLYRLCGsaaKKKELRDAFERNsaavelseELYPDiNV----- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  627 saydVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVP---KEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDEN 703
Cdd:cd04379    76 ----ITGVLKDYLRELPEPLITPQLYEMVLEALAVALpndVQTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERN 151

                         170
                  ....*....|....*.
gi 564377887  704 QMTPMNLAVCLAPSLF 719
Cdd:cd04379   152 KMTPQNLAVCFGPVLM 167
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 592-718 3.94e-13

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 69.07  E-value: 3.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  592 LDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHI---YQYVPKEQR- 667
Cdd:cd04408    32 LGVQGIYRISGSKARVEKLCQAFENGRDLVDLSGHSPHDITSVLKHFLKELPEPVLPFQLYDDFIALakeLQRDSEKAAe 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 564377887  668 --------LQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSL 718
Cdd:cd04408   112 spsiveniIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPTL 170
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 560-718 9.45e-13

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 67.77  E-value: 9.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  560 VFGVPLIVHVQRT-----GQPLPQSIQQALRYLRSN-CLDQVGLFRKSGVKSRIhalRQMNENFPDNVSY---EDQSAYD 630
Cdd:cd04400     1 IFGSPLEEAVELSshkynGRDLPSVVYRCIEYLDKNrAIYEEGIFRLSGSASVI---KQLKERFNTEYDVdlfSSSLYPD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  631 ---VADMVKQFFRDLPEPLFTNKLSETFLHIyqyvpKEQRLQAVQAAILL------LADENREALQTLLCFLHDVVNLVD 701
Cdd:cd04400    78 vhtVAGLLKLYLRELPTLILGGELHNDFKRL-----VEENHDRSQRALELkdlvsqLPQANYDLLYVLFSFLRKIIEHSD 152

                         170
                  ....*....|....*..
gi 564377887  702 ENQMTPMNLAVCLAPSL 718
Cdd:cd04400   153 VNKMNLRNVCIVFSPTL 169
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 561-718 2.31e-12

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 66.88  E-value: 2.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  561 FGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALR-QMNENFPDNVS-YEDQSAYDVADMVKQF 638
Cdd:cd04387     1 FGVKISTVTKRERSKVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKaAFDTNNKDVSVmLSEMDVNAIAGTLKLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  639 FRDLPEPLFTNKLSETF---LHIYQYVPKEQRLQAVqaaILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLA 715
Cdd:cd04387    81 FRELPEPLFTDELYPNFaegIALSDPVAKESCMLNL---LLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFG 157


                  ...
gi 564377887  716 PSL 718
Cdd:cd04387   158 PTL 160
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 561-718 1.08e-11

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 64.85  E-value: 1.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  561 FGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALR----------QMNEN-FPD-NVsyedqsa 628
Cdd:cd04372     1 YGCDLTTLVKAHNTQRPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKmafdrdgekaDISATvYPDiNV------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  629 ydVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPM 708
Cdd:cd04372    74 --ITGALKLYFRDLPIPVITYDTYPKFIDAAKISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAE 151

                         170
                  ....*....|
gi 564377887  709 NLAVCLAPSL 718
Cdd:cd04372   152 NLGIVFGPTL 161
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 560-719 1.28e-11

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 65.51  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  560 VFGVPL----------IVHVQRTGQPL-----PQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPD---NV 621
Cdd:cd04396     1 VFGVSLeeslkyasvaISIVDEDGEQYvygyiPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTPPDygkSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  622 SYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETF----------LHIYQYVPKE-------QRLQAVQAAILLLADENRE 684
Cdd:cd04396    81 DWDGYTVHDAASVLRRYLNNLPEPLVPLDLYEEFrnplrkrpriLQYMKGRINEplntdidQAIKEYRDLITRLPNLNRQ 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 564377887  685 ALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLF 719
Cdd:cd04396   161 LLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGIL 195
START_STARD10-like cd08871
Lipid-binding START domain of mammalian STARD10 and related proteins; This subfamily includes ...
 823-981 1.39e-10

Lipid-binding START domain of mammalian STARD10 and related proteins; This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD10 (also known as CGI-52, PTCP-like, and SDCCAG28). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD10 binds phophatidylcholine and phosphatidylethanolamine. This protein is widely expressed and is synthesized constitutively in many organs. It may function in the liver in the export of phospholipids into bile. It is concentrated in the sperm flagellum, and may play a role in energy metabolism. In the mammary gland it may participate in the enrichment of lipids in milk, and be a potential marker of differentiation. Its expression is induced in this gland during gestation and lactation. It is overexpressed in mammary tumors from Neu/ErbB2 transgenic mice, in several breast carcinoma cell lines, and in 35% of primary human breast cancers, and may cooperate with c-erbB receptor signaling in breast oncogenesis. It is a potential marker of disease outcome in breast cancer; loss of STARD10 expression in breast cancer strongly predicts an aggressive disease course. The lipid transfer activity of STRAD10 is downregulated by phosphorylation of its Ser284 by CK2 (casein kinase 2).


Pssm-ID: 176880  Cd Length: 222  Bit Score: 62.27  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  823 EKFK-------GWVTCSSPDNTDLAFKKVgDGNPLKLWKASVE-VEAPPSVVLNrVLRE---RHLWDEDFVQWKVVETLD 891
Cdd:cd08871    13 EEFKklcdstdGWKLKYNKNNVKVWTKNP-ENSSIKMIKVSAIfPDVPAETLYD-VLHDpeyRKTWDSNMIESFDICQLN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  892 RQTEIYQYVLNSMVPHPSRDFVVLRTW-KTDlpkGMCTLVSLSVEHEEA-QLMGDVRAVVMDSQYLIEPCGSGKSRLTHI 969
Cdd:cd08871    91 PNNDIGYYSAKCPKPLKNRDFVNLRSWlEFG---GEYIIFNHSVKHKKYpPRKGFVRAISLLTGYLIRPTGPKGCTLTYV 167

                         170
                  ....*....|..
gi 564377887  970 CRIDLKGHSPEW 981
Cdd:cd08871   168 TQNDPKGSLPKW 179
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 559-719 1.55e-09

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 58.61  E-value: 1.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  559 AVFGVPL---IVHVQRTGQPL-PQSIQQALRYLRSNCLDQVGLFRKSGVKSRIhalRQMNENFP--DNVSYE-DQSAYDV 631
Cdd:cd04390     1 GVFGQRLedtVAYERKFGPRLvPILVEQCVDFIREHGLKEEGLFRLPGQANLV---KQLQDAFDagERPSFDsDTDVHTV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  632 ADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPK--EQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMN 709
Cdd:cd04390    78 ASLLKLYLRELPEPVIPWAQYEDFLSCAQLLSKdeEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQN 157

                         170
                  ....*....|
gi 564377887  710 LAVCLAPSLF 719
Cdd:cd04390   158 LATVFGPNIL 167
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 596-733 1.34e-08

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 55.86  E-value: 1.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  596 GLFRKSGVKSRIHALR-QMNE-NFPDNvSYEDqsAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYqyvpkEQRLQAVqA 673
Cdd:cd04389    42 GIFRVPGDIDEVNELKlRVDQwDYPLS-GLED--PHVPASLLKLWLRELEEPLIPDALYQQCISAS-----EDPDKAV-E 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564377887  674 AILLLADENREALQTLLCFLHDVVN--LVDENQMTPMNLAVCLAPslfhlNLLKKES-SPRVI 733
Cdd:cd04389   113 IVQKLPIINRLVLCYLINFLQVFAQpeNVAHTKMDVSNLAMVFAP-----NILRCTSdDPRVI 170
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 592-719 1.37e-08

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 55.76  E-value: 1.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  592 LDQVGLFRKSGVKSRIHALRqmnENF-----PDNVSYEDqsAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQ 666
Cdd:cd04382    33 LTEEGLYRVSGSEREVKALK---EKFlrgktVPNLSKVD--IHVICGCLKDFLRSLKEPLITFALWKEFMEAAEILDEDN 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 564377887  667 RLQAVQAAILLLADENREALQTLlcFLH-DVVNLVDENQMTPMNLAVCLAPSLF 719
Cdd:cd04382   108 SRAALYQAISELPQPNRDTLAFL--ILHlQRVAQSPECKMDINNLARVFGPTIV 159
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 560-693 2.48e-08

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 55.80  E-value: 2.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  560 VFGVPLIVHVQRTGQPLPQSIQQ--ALRYLRSNCLDQ--VGLFRKSG----VKSRIHALrqmnENFPDNVSYE-DQSAYD 630
Cdd:cd04405    21 LVGLPLLEELLDPALVNPKHISYnmDPDVYTSNYLDRevVKLFSKSQldhwLLSAMDCL----ANWPDQLVVDvSRPLYS 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564377887  631 VADMVKQFFRDL-----------PEPLFTNKLSETFLHI---YQYVPKEQRLQAVQAAILLLADENREALQTLLCFL 693
Cdd:cd04405    97 QHDMLSGFKRLLfktiakyygqlKEPLLTFHLFDIFVGIlelLGNGKEEVALEALQLCLLLLPPASRRELRRLLRFM 173
START_1 cd08876
Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid ...
 846-981 5.25e-06

Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Functionally uncharacterized subgroup of the START domain family. The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some mammalian members of the START family (STARDs), it is known which lipids bind in this pocket; these include cholesterol (STARD1, -3, -4, and -5), 25-hydroxycholesterol (STARD5), phosphatidylcholine (STARD2, -7, and -10), phosphatidylethanolamine (STARD10) and ceramides (STARD11). Mammalian STARDs participate in the control of various cellular processes, including lipid trafficking between intracellular compartments, lipid metabolism, and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer, genetic disorders, and autoimmune disease.


Pssm-ID: 176885  Cd Length: 195  Bit Score: 48.04  E-value: 5.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  846 DGNPLKLWKASVEVEAPPSVVLNrVLRErhlwDEDFVQW-------KVVETLDRQTEIYQYVLNSMVPHPSRDFVVL-RT 917
Cdd:cd08876    36 EGSPLKEFKAVAEVDASIEAFLA-LLRD----TESYPQWmpnckesRVLKRTDDNERSVYTVIDLPWPVKDRDMVLRsTT 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564377887  918 WKTDLPKGMCTLVSlSVEHEEAQLMGDVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPEW 981
Cdd:cd08876   111 EQDADDGSVTITLE-AAPEALPEQKGYVRIKTVEGQWTFTPLGNGKTRVTYQAYADPGGSIPGW 173
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 586-720 2.21e-03

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 40.79  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377887  586 YLRSNCLDQVGLFRKSGVKSR--------IHALrqmNENFPDNVSYedqSAYDVADMVKQFFRDLPEPLFTNKLSETfLH 657
Cdd:cd04380    60 YLYTRGLAQEGLFEEPGLPSEpgellaeiRDAL---DTGSPFNSPG---SAESVAEALLLFLESLPDPIIPYSLYER-LL 132

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564377887  658 IYQYVPKEQRLQAVQAAillLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLFH 720
Cdd:cd04380   133 EAVANNEEDKRQVIRIS---LPPVHRNVFVYLCSFLRELLSESADRGLDENTLATIFGRVLLR 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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