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Conserved domains on  [gi|564377838|ref|XP_006248792|]
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mitotic-spindle organizing protein 2B isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MOZART2 super family cl15169
Mitotic-spindle organizing gamma-tubulin ring associated; FAM128A and FAM128B proteins have ...
 15-97 4.82e-39

Mitotic-spindle organizing gamma-tubulin ring associated; FAM128A and FAM128B proteins have been re-named MOZART2A and B. The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, the MOZART proteins, both 1 and 2, do not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. The exact function of MOZART2 is not clear.


The actual alignment was detected with superfamily member pfam12926:

Pssm-ID: 432879  Cd Length: 90  Bit Score: 127.65  E-value: 4.82e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377838   15 STGL-EAATLQKLALRRKKVLGAEEMELYELSQAAGAAIDPDVFKILVDLLNLNVAPLAVFQMLKSMCAGQRLA-SDPQD 92
Cdd:pfam12926   6 SPSLvVSGNVQKYAIKKKKVLNAEEMELYELTQAAGIVIDQEVFKIIVDLLKMNVAPLAVFQTLKSMCAGQRVSeSSGGD 85


                  ....*
gi 564377838   93 SVSMS 97
Cdd:pfam12926  86 TSSAS 90
 
Name Accession Description Interval E-value
MOZART2 pfam12926
Mitotic-spindle organizing gamma-tubulin ring associated; FAM128A and FAM128B proteins have ...
 15-97 4.82e-39

Mitotic-spindle organizing gamma-tubulin ring associated; FAM128A and FAM128B proteins have been re-named MOZART2A and B. The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, the MOZART proteins, both 1 and 2, do not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. The exact function of MOZART2 is not clear.


Pssm-ID: 432879  Cd Length: 90  Bit Score: 127.65  E-value: 4.82e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377838   15 STGL-EAATLQKLALRRKKVLGAEEMELYELSQAAGAAIDPDVFKILVDLLNLNVAPLAVFQMLKSMCAGQRLA-SDPQD 92
Cdd:pfam12926   6 SPSLvVSGNVQKYAIKKKKVLNAEEMELYELTQAAGIVIDQEVFKIIVDLLKMNVAPLAVFQTLKSMCAGQRVSeSSGGD 85


                  ....*
gi 564377838   93 SVSMS 97
Cdd:pfam12926  86 TSSAS 90
 
Name Accession Description Interval E-value
MOZART2 pfam12926
Mitotic-spindle organizing gamma-tubulin ring associated; FAM128A and FAM128B proteins have ...
 15-97 4.82e-39

Mitotic-spindle organizing gamma-tubulin ring associated; FAM128A and FAM128B proteins have been re-named MOZART2A and B. The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, the MOZART proteins, both 1 and 2, do not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. The exact function of MOZART2 is not clear.


Pssm-ID: 432879  Cd Length: 90  Bit Score: 127.65  E-value: 4.82e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564377838   15 STGL-EAATLQKLALRRKKVLGAEEMELYELSQAAGAAIDPDVFKILVDLLNLNVAPLAVFQMLKSMCAGQRLA-SDPQD 92
Cdd:pfam12926   6 SPSLvVSGNVQKYAIKKKKVLNAEEMELYELTQAAGIVIDQEVFKIIVDLLKMNVAPLAVFQTLKSMCAGQRVSeSSGGD 85


                  ....*
gi 564377838   93 SVSMS 97
Cdd:pfam12926  86 TSSAS 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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