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Conserved domains on  [gi|564370116|ref|XP_006245688|]
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rho GTPase-activating protein 28 isoform X2 [Rattus norvegicus]

Protein Classification

rho GTPase-activating protein( domain architecture ID 10138216)

rho GTPase-activating protein (GAP) acts by converting Rho-type GTPases to an inactive GDP-bound state, similar to human Rho GAP 18 that suppresses F-actin polymerization by inhibiting Rho

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 360-571 5.77e-116

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239856  Cd Length: 216  Bit Score: 347.41  E-value: 5.77e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 360 IFGVPLTVLLDNDRKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNTDKFKWDKMCHREAA 439
Cdd:cd04391    1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEGTFLWDQVKQHDAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 440 VMLKAFFRELPTSLFPIEYIPAFISlMERGPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNIS 519
Cdd:cd04391   81 SLLKLFIRELPQPLLTVEYLPAFYS-VQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564370116 520 TVMAPNLFFSRSKHS-----DCEELLVANTAAHIIRLMLTYQKILWKVPSFLITQVR 571
Cdd:cd04391  160 MIMAPNLFPPRGKHSkdnesLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 360-571 5.77e-116

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 347.41  E-value: 5.77e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 360 IFGVPLTVLLDNDRKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNTDKFKWDKMCHREAA 439
Cdd:cd04391    1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEGTFLWDQVKQHDAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 440 VMLKAFFRELPTSLFPIEYIPAFISlMERGPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNIS 519
Cdd:cd04391   81 SLLKLFIRELPQPLLTVEYLPAFYS-VQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564370116 520 TVMAPNLFFSRSKHS-----DCEELLVANTAAHIIRLMLTYQKILWKVPSFLITQVR 571
Cdd:cd04391  160 MIMAPNLFPPRGKHSkdnesLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 382-531 8.57e-44

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 154.24  E-value: 8.57e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116  382 PLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNTDKFkWDKMCHREAAVMLKAFFRELPTSLFPIEYIPA 461
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLD-LEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116  462 FISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRS 531
Cdd:pfam00620  80 FIEAAKL-PDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 381-535 6.80e-35

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 130.46  E-value: 6.80e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116   381 VPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELD--ARFNTDKFKWDKMChreAAVMLKAFFRELPTSLFPIEY 458
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDsgPDPDLDLSEYDVHD---VAGLLKLFLRELPEPLITYEL 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564370116   459 IPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSD 535
Cdd:smart00324  80 YEEFIEAAKL-EDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVA 155
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 360-571 5.77e-116

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 347.41  E-value: 5.77e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 360 IFGVPLTVLLDNDRKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNTDKFKWDKMCHREAA 439
Cdd:cd04391    1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEGTFLWDQVKQHDAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 440 VMLKAFFRELPTSLFPIEYIPAFISlMERGPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNIS 519
Cdd:cd04391   81 SLLKLFIRELPQPLLTVEYLPAFYS-VQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564370116 520 TVMAPNLFFSRSKHS-----DCEELLVANTAAHIIRLMLTYQKILWKVPSFLITQVR 571
Cdd:cd04391  160 MIMAPNLFPPRGKHSkdnesLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 382-531 8.57e-44

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 154.24  E-value: 8.57e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116  382 PLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNTDKFkWDKMCHREAAVMLKAFFRELPTSLFPIEYIPA 461
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLD-LEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116  462 FISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRS 531
Cdd:pfam00620  80 FIEAAKL-PDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 382-555 4.50e-40

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 144.75  E-value: 4.50e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 382 PLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDA-RFNTDKFKWDkmCHrEAAVMLKAFFRELPTSLFPIEYIP 460
Cdd:cd00159    1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRgEDIDDLEDYD--VH-DVASLLKLYLRELPEPLIPFELYD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 461 AFISLMeRGPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFfsRSKHSDCEELL 540
Cdd:cd00159   78 EFIELA-KIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLL--RPPDSDDELLE 154

                        170
                 ....*....|....*
gi 564370116 541 VANTAAHIIRLMLTY 555
Cdd:cd00159  155 DIKKLNEIVEFLIEN 169
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 381-535 6.80e-35

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 130.46  E-value: 6.80e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116   381 VPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELD--ARFNTDKFKWDKMChreAAVMLKAFFRELPTSLFPIEY 458
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDsgPDPDLDLSEYDVHD---VAGLLKLFLRELPEPLITYEL 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564370116   459 IPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSD 535
Cdd:smart00324  80 YEEFIEAAKL-EDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVA 155
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 361-527 7.73e-27

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 108.26  E-value: 7.73e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 361 FGVPLTVLLDNDrkkdpAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARF------NTDKFKWDKMC 434
Cdd:cd04398    1 FGVPLEDLILRE-----GDNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPlnvlliSPEDYESDIHS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 435 hreAAVMLKAFFRELPTSLFPIEYIPAFISLMeRGPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMS 514
Cdd:cd04398   76 ---VASLLKLFFRELPEPLLTKALSREFIEAA-KIEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMS 151

                        170
                 ....*....|...
gi 564370116 515 LWNISTVMAPNLF 527
Cdd:cd04398  152 VNNLAIIWGPTLM 164
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 361-554 2.73e-25

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 103.62  E-value: 2.73e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 361 FGVPLTVLLDndRKKDpavKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREEL--DARFNTDKFKWDKMCHREA 438
Cdd:cd04403    1 FGCHLEALCQ--RENS---TVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVdhDEKLDLDDSKWEDIHVITG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 439 AvmLKAFFRELPTSLFPIEYIPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNI 518
Cdd:cd04403   76 A--LKLFFRELPEPLFPYSLFNDFVAAIKL-SDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNL 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 564370116 519 STVMAPNLFfsrskHSDCEEllvANTAAH------IIRLMLT 554
Cdd:cd04403  153 AIVFGPTLL-----RPEQET---GNIAVHmvyqnqIVELILL 186
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 378-563 1.43e-24

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 102.13  E-value: 1.43e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 378 AVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDArfNTDKFKWDKMCHREAAVMLKAFFRELPTSLFPIE 457
Cdd:cd04376    6 ARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR--GIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 458 YIPAFISLMERGPDIkvQFQALHLMVMALPDANRDTAQALMTFFNKVIANE-----------SKNRMSLWNISTVMAPNL 526
Cdd:cd04376   84 LYTAFIGTALLEPDE--QLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAadsidedgqevSGNKMTSLNLATIFGPNL 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 564370116 527 fFSRSKHSDCEELLVANTAAH------IIRLMLTYQKILWKVP 563
Cdd:cd04376  162 -LHKQKSGEREFVQASLRIEEstaiinVVQTMIDNYEELFMVS 203
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 361-524 2.65e-24

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 100.59  E-value: 2.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 361 FGVPLTVLLDNDRKkdpavkVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDArfNTDKFKWDKMCHREAAV 440
Cdd:cd04377    1 FGVSLSSLTSEDRS------VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDT--DPDSVNLEDYPIHVITS 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 441 MLKAFFRELPTSLFPIEYIPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNIST 520
Cdd:cd04377   73 VLKQWLRELPEPLMTFELYENFLRAMEL-EEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAI 151


                 ....
gi 564370116 521 VMAP 524
Cdd:cd04377  152 VFAP 155
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 357-564 7.73e-24

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 100.18  E-value: 7.73e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 357 DNGIFGVPLTVLLDndRKKDPavkVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDArfNTDKFKWDKMCHR 436
Cdd:cd04375    1 DKNVFGVPLLVNLQ--RTGQP---LPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIES--STDNVNYDGQQAY 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 437 EAAVMLKAFFRELPTSLFPIEYIPAFISLMERGPDiKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLW 516
Cdd:cd04375   74 DVADMLKQYFRDLPEPLLTNKLSETFIAIFQYVPK-EQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTAT 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564370116 517 NISTVMAPNLF-FSRSKHSDC----------------EELLVANTAAHI-IRLMLTYQKILWKVPS 564
Cdd:cd04375  153 NLAVCLAPSLFhLNTSRRENSsparrmqrkkslgkpdQKELSENKAAHQcLAYMIEECNTLFMVPK 218
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 360-526 2.48e-22

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 95.12  E-value: 2.48e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 360 IFGVPLTVLLDNDRKKDPAVKVPLVLQKFFQKVEESGLE-SEGIFRLSGCTAKVKQYREELDARFNTDKFKWDKMCHREA 438
Cdd:cd04400    1 IFGSPLEEAVELSSHKYNGRDLPSVVYRCIEYLDKNRAIyEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSLYPDVHT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 439 -AVMLKAFFRELPTSLFPIEYIPAFISLMERGPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWN 517
Cdd:cd04400   81 vAGLLKLYLRELPTLILGGELHNDFKRLVEENHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRN 160


                 ....*....
gi 564370116 518 ISTVMAPNL 526
Cdd:cd04400  161 VCIVFSPTL 169
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 361-566 4.94e-22

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 94.74  E-value: 4.94e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 361 FGVPLTVLL-----DNDRKKDP-AVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNTDKFKWDKMC 434
Cdd:cd04397    1 FGVPLEILVekfgaDSTLGVGPgKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVPDLSKENP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 435 HREAAvMLKAFFRELPTSLFPIEYIPAFISlMERGPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKV-----IANES 509
Cdd:cd04397   81 VQLAA-LLKKFLRELPDPLLTFKLYRLWIS-SQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVssfshIDEET 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564370116 510 KNRMSLWNISTVMAPNLFFSRSKHSDC-EELLVANTAAHiirLMLTYQKILWKVPSFL 566
Cdd:cd04397  159 GSKMDIHNLATVITPNILYSKTDNPNTgDEYFLAIEAVN---YLIENNEEFCEVPDEL 213
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 360-549 1.06e-21

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 93.30  E-value: 1.06e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 360 IFGVPLTVLldnDRKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNTDKFKWDKMChrEAA 439
Cdd:cd04393    2 VFGVPLQEL---QQAGQPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVC--SAA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 440 VMLKAFFRELPTSLFPIEYIPAFISLMERGPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNIS 519
Cdd:cd04393   77 SLLRLFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLA 156

                        170       180       190
                 ....*....|....*....|....*....|.
gi 564370116 520 TVMAPNLFFSRSKHSDCEEL-LVANTAAHII 549
Cdd:cd04393  157 AVFGPDVFHVYTDVEDMKEQeICSRIMAKLL 187
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 361-557 1.24e-21

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 93.17  E-value: 1.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 361 FGVPLTVLLDNDRKKDPavkVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKqyreELDARFNTDK---FKWDKMCHRe 437
Cdd:cd04404    6 FGVSLQFLKEKNPEQEP---IPPVVRETVEYLQAHALTTEGIFRRSANTQVVK----EVQQKYNMGEpvdFDQYEDVHL- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 438 AAVMLKAFFRELPTSLFPIEYIPAFISLMERGPDIKVQfqALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWN 517
Cdd:cd04404   78 PAVILKTFLRELPEPLLTFDLYDDIVGFLNVDKEERVE--RVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSN 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 564370116 518 ISTVMAPNLFFSRSKHSDCEELLVANTaahIIRLMLTYQK 557
Cdd:cd04404  156 LAVVFGPNLLWAKDASMSLSAINPINT---FTKFLLDHQD 192
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 361-535 1.26e-20

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 90.37  E-value: 1.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 361 FGVPLTVLLDNDRkkdpaVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNTDKFKWDKMCHREAAV 440
Cdd:cd04387    1 FGVKISTVTKRER-----SKVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNKDVSVMLSEMDVNAIAG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 441 MLKAFFRELPTSLFPIEYIPAFISLMERGPDIKVQFQALHLMvMALPDANRDTAQALMTFFNKVIANESKNRMSLWNIST 520
Cdd:cd04387   76 TLKLYFRELPEPLFTDELYPNFAEGIALSDPVAKESCMLNLL-LSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLAT 154

                        170
                 ....*....|....*
gi 564370116 521 VMAPNLFFSRSKHSD 535
Cdd:cd04387  155 VFGPTLLRPSEKESK 169
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 360-551 1.03e-19

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 87.90  E-value: 1.03e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 360 IFGVPLtvlldNDRKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDA-RFNTDKFKWDKMCHREA 438
Cdd:cd04386    4 VFGTPL-----EEHLKRTGREIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAgTFSLPLDEFYSDPHAVA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 439 AVmLKAFFRELPTSLFPIEYIPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNI 518
Cdd:cd04386   79 SA-LKSYLRELPDPLLTYNLYEDWVQAANK-PDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNI 156

                        170       180       190
                 ....*....|....*....|....*....|...
gi 564370116 519 STVMAPNLFFSRSKHSDCEelLVANTAAHIIRL 551
Cdd:cd04386  157 AIVLAPNLLWAKNEGSLAE--MAAGTSVHVVAI 187
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 361-556 1.51e-18

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 84.04  E-value: 1.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 361 FGVPLTVLLDNDRKkdpavkVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNTDKFKWDKMCHrEAAV 440
Cdd:cd04373    1 FGVPLANVVTSEKP------IPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDFTVN-AVAG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 441 MLKAFFRELPTSLFPIEYIPAFISLMERGPDIKvQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNIST 520
Cdd:cd04373   74 ALKSFFSELPDPLIPYSMHLELVEAAKINDREQ-RLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSI 152

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 564370116 521 VMAPNLFfsRSKHSDCEELLVANTAAHIIRlMLTYQ 556
Cdd:cd04373  153 CFWPTLM--RPDFTSMEALSATRIYQTIIE-TFIQQ 185
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 381-527 2.16e-18

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 83.51  E-value: 2.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 381 VPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREEL--DARfntdKFKWDKMCHREAAV--MLKAFFRELPTSLFPI 456
Cdd:cd04385   15 IPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFrkDAR----SVQLREGEYTVHDVadVLKRFLRDLPDPLLTS 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564370116 457 EYIPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNISTVMAPNLF 527
Cdd:cd04385   91 ELHAEWIEAAEL-ENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLF 160
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 361-526 2.21e-18

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 83.99  E-value: 2.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 361 FGVPLTVLLDNDRKKdpavKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARF---NTDKFKWDKMchRE 437
Cdd:cd04395    2 FGVPLDDCPPSSENP----YVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGfdiDLQDPRWRDV--NV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 438 AAVMLKAFFRELPTSLFPIEYIPAFISlMERGPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWN 517
Cdd:cd04395   76 VSSLLKSFFRKLPEPLFTNELYPDFIE-ANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRN 154


                 ....*....
gi 564370116 518 ISTVMAPNL 526
Cdd:cd04395  155 LAIVFGPTL 163
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 361-526 8.54e-18

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 82.18  E-value: 8.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 361 FGVPLTVLLdndrKKDPAvKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVkqyrEELDARFNTDKFKWDKMCHREAAV 440
Cdd:cd04372    1 YGCDLTTLV----KAHNT-QRPMVVDMCIREIEARGLQSEGLYRVSGFAEEI----EDVKMAFDRDGEKADISATVYPDI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 441 -----MLKAFFRELPTSLFPIEYIPAFISLMeRGPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSL 515
Cdd:cd04372   72 nvitgALKLYFRDLPIPVITYDTYPKFIDAA-KISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNA 150

                        170
                 ....*....|.
gi 564370116 516 WNISTVMAPNL 526
Cdd:cd04372  151 ENLGIVFGPTL 161
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 360-567 1.01e-17

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 82.13  E-value: 1.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 360 IFGVPLTVLLDNDRKKDPAVKVPLVLQKFFQkveESGLESEGIFRLSGCTAKVKQYREELDARFNTDKFKwdKMChrEAA 439
Cdd:cd04394    1 VFGVPLHSLPHSTVPEYGNVPKFLVDACTFL---LDHLSTEGLFRKSGSVVRQKELKAKLEGGEACLSSA--LPC--DVA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 440 VMLKAFFRELPTSLFPIEYIPAFISLMERGPDiKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNIS 519
Cdd:cd04394   74 GLLKQFFRELPEPLLPYDLHEALLKAQELPTD-EERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLA 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 564370116 520 TVMAPNLFFSRSKHSDCEELLVANTA--AHIIRLMLTYQKILWKVPSFLI 567
Cdd:cd04394  153 VIFAPNLFQSEEGGEKMSSSTEKRLRlqAAVVQTLIDNASNIGIVPDFIL 202
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 361-530 1.30e-17

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 81.74  E-value: 1.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 361 FGVPLTVLLdndRKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREEldarFNTDkfkwdkmchrEAAV 440
Cdd:cd04379    1 FGVPLSRLV---EREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDA----FERN----------SAAV 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 441 ---------------MLKAFFRELPTSLFPIEYIPAFISLMERGPDIKVQFQALHLMVM--ALPDANRDTAQALMTFFNK 503
Cdd:cd04379   64 elseelypdinvitgVLKDYLRELPEPLITPQLYEMVLEALAVALPNDVQTNTHLTLSIidCLPLSAKATLLLLLDHLSL 143

                        170       180
                 ....*....|....*....|....*..
gi 564370116 504 VIANESKNRMSLWNISTVMAPNLFFSR 530
Cdd:cd04379  144 VLSNSERNKMTPQNLAVCFGPVLMFCS 170
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 361-529 1.88e-17

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 80.94  E-value: 1.88e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 361 FGVPLTVLLDNDRKKDpAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNTDKFKWDKmchREAAV 440
Cdd:cd04381    1 FGASLSLAVERSRCHD-GIDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEYEP---PTVAS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 441 MLKAFFRELPTSLFPIEYIPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNIST 520
Cdd:cd04381   77 LLKQYLRELPEPLLTKELMPRFEEACGR-PTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISI 155


                 ....*....
gi 564370116 521 VMAPNLFFS 529
Cdd:cd04381  156 VLSPTVQIS 164
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 361-527 1.93e-17

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 80.81  E-value: 1.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 361 FGVPLTVLLDNdrkKDPavkVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNTDKFKwDKMCHREAAV 440
Cdd:cd04407    1 FGVRVGSLTSN---KTS---VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKLE-NYPIHAITGL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 441 mLKAFFRELPTSLFPIEYIPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNIST 520
Cdd:cd04407   74 -LKQWLRELPEPLMTFAQYNDFLRAVEL-PEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAI 151


                 ....*..
gi 564370116 521 VMAPNLF 527
Cdd:cd04407  152 VFAPCLL 158
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 360-548 1.93e-16

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 78.31  E-value: 1.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 360 IFGVPLTVLLDNDRKKdpavkVPLVLQKFFQKVEESGLeSEGIFRLSGCTAKVKQYREELDARFNTDKFKwDKMCHREAA 439
Cdd:cd04384    2 VFGCDLTEHLLNSGQD-----VPQVLKSCTEFIEKHGI-VDGIYRLSGIASNIQRLRHEFDSEQIPDLTK-DVYIQDIHS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 440 V--MLKAFFRELPTSLFPIEYIPAFISLMERGPDiKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWN 517
Cdd:cd04384   75 VssLCKLYFRELPNPLLTYQLYEKFSEAVSAASD-EERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKN 153

                        170       180       190
                 ....*....|....*....|....*....|.
gi 564370116 518 ISTVMAPNLFFSRSKHSDCeellVANTAAHI 548
Cdd:cd04384  154 LAIVWAPNLLRSKQIESAC----FSGTAAFM 180
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 359-535 1.30e-15

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 75.94  E-value: 1.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 359 GIFGVPLTVLLDNDRKKDPAVkVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARfNTDKFKWDKMCHREA 438
Cdd:cd04390    1 GVFGQRLEDTVAYERKFGPRL-VPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAG-ERPSFDSDTDVHTVA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 439 AvMLKAFFRELPTSLFPIEYIPAFISLMER-GPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWN 517
Cdd:cd04390   79 S-LLKLYLRELPEPVIPWAQYEDFLSCAQLlSKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQN 157

                        170
                 ....*....|....*...
gi 564370116 518 ISTVMAPNLFfsRSKHSD 535
Cdd:cd04390  158 LATVFGPNIL--RPKVED 173
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 360-559 2.45e-14

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 72.83  E-value: 2.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 360 IFGVPLT----------VLLDNDRKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKqyreELDARFNT---- 425
Cdd:cd04396    1 VFGVSLEeslkyasvaiSIVDEDGEQYVYGYIPVVVAKCGVYLKENATEVEGIFRVAGSSKRIR----ELQLIFSTppdy 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 426 -DKFKWDKMCHREAAVMLKAFFRELPTSLFPIEYIPAFISLMERGPDIKVQFQALH----------------LMVMALPD 488
Cdd:cd04396   77 gKSFDWDGYTVHDAASVLRRYLNNLPEPLVPLDLYEEFRNPLRKRPRILQYMKGRIneplntdidqaikeyrDLITRLPN 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564370116 489 ANRDTAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDCEELLVANTaahIIRLMLTYQKIL 559
Cdd:cd04396  157 LNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGILSHPDHEMDPKEYKLSRL---VVEFLIEHQDKF 224
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 394-571 9.18e-13

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 67.87  E-value: 9.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 394 ESGLESEGIFRLSGCTAKVKQYREELDARFNTDKFKWDKMCHrEAAVMLKAFFRELPTSLFPIEYIPAFISLME------ 467
Cdd:cd04392   21 EKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAH-DCATVLKGFLGELPEPLLTHAHYPAHLQIADlcqfde 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 468 -----RGPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSdcEELLV- 541
Cdd:cd04392  100 kgnktSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRNLTP--EDLHEn 177

                        170       180       190
                 ....*....|....*....|....*....|
gi 564370116 542 ANTAAHIIRLMLTYQKILWKVPSFLITQVR 571
Cdd:cd04392  178 AQKLNSIVTFMIKHSQKLFKAPAYLREDAR 207
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 361-524 5.82e-12

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 65.02  E-value: 5.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 361 FGVPLTVLLDNDRKkdpavkVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNTDKFKwDKMCHREAAV 440
Cdd:cd04406    1 FGVELSRLTSEDRS------VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLD-DYNIHVIASV 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 441 mLKAFFRELPTSLFPIEYIPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNIST 520
Cdd:cd04406   74 -FKQWLRDLPNPLMTFELYEEFLRAMGL-QERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAI 151


                 ....
gi 564370116 521 VMAP 524
Cdd:cd04406  152 VFAP 155
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 361-535 1.03e-11

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 64.33  E-value: 1.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 361 FGVPLTVLLDNDRKKDPAVKVPLVLQKFFQKVEES-GLESEGIFRLSGCTAKVKqyreELDARFNTDKFKWDKMCH-REA 438
Cdd:cd04389    1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALgGFQTEGIFRVPGDIDEVN----ELKLRVDQWDYPLSGLEDpHVP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 439 AVMLKAFFRELPTSLFPIEYIPAFISLMERgPDIKVQfqalhlMVMALPDANRDTAQALMTFFNKVI--ANESKNRMSLW 516
Cdd:cd04389   77 ASLLKLWLRELEEPLIPDALYQQCISASED-PDKAVE------IVQKLPIINRLVLCYLINFLQVFAqpENVAHTKMDVS 149

                        170
                 ....*....|....*....
gi 564370116 517 NISTVMAPNlfFSRSKHSD 535
Cdd:cd04389  150 NLAMVFAPN--ILRCTSDD 166
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 360-526 2.47e-11

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 63.09  E-value: 2.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 360 IFGVPLTVLLDNDRKKDPAVKVPLVLqkfFQKveesGLESEGIFRLSGCTAKVKQYREELDARFNTDkfkwdkmCHREA- 438
Cdd:cd04402    1 LFGQPLSNICEDDNLPKPILDMLSLL---YQK----GPSTEGIFRRSANAKACKELKEKLNSGVEVD-------LKAEPv 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 439 ---AVMLKAFFRELPTSLFPIEYIPAFISLMERGPDIKVQfQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSL 515
Cdd:cd04402   67 lllASVLKDFLRNIPGSLLSSDLYEEWMSALDQENEEEKI-AELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDA 145

                        170
                 ....*....|.
gi 564370116 516 WNISTVMAPNL 526
Cdd:cd04402  146 FNLAVCIAPSL 156
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 385-526 6.03e-11

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 62.41  E-value: 6.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 385 LQKFFQKVEESGLESEGIFRLSGCTAKV-KQYREELDARFNTD---KFKWDKMCHREAAVMLKAFFRELPTSLFPIEYIP 460
Cdd:cd04374   32 VRKCIEAVETRGINEQGLYRVVGVNSKVqKLLSLGLDPKTSTPgdvDLDNSEWEIKTITSALKTYLRNLPEPLMTYELHN 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564370116 461 AFISLMERG-PDIKVQfqALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNISTVMAPNL 526
Cdd:cd04374  112 DFINAAKSEnLESRVN--AIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTL 176
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 380-526 4.93e-10

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 59.83  E-value: 4.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 380 KVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVkqyrEELDARFNTDKFKWDKMCH--REAAVMLKAFFRELPTSLFPIE 457
Cdd:cd04408   15 EVPFVVVRCTAEIENRALGVQGIYRISGSKARV----EKLCQAFENGRDLVDLSGHspHDITSVLKHFLKELPEPVLPFQ 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 458 YIPAFISL---MERGPDIKVQ--------FQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNISTVMAPNL 526
Cdd:cd04408   91 LYDDFIALakeLQRDSEKAAEspsiveniIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPTL 170
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 381-555 1.27e-09

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 58.59  E-value: 1.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 381 VPLVLQKFFQKVEESGLESEGIFRLSGCTAKVkqyrEELDARFNTDKFKWDKMCHREAAV--MLKAFFRELPTSLFPIEY 458
Cdd:cd04378   16 VPFIIKKCTSEIENRALGVQGIYRVSGSKARV----EKLCQAFENGKDLVELSELSPHDIssVLKLFLRQLPEPLILFRL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 459 IPAFISLM----------------ERGPDIKVQFQALhlmVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNISTVM 522
Cdd:cd04378   92 YNDFIALAkeiqrdteedkapntpIEVNRIIRKLKDL---LRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVF 168

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 564370116 523 APNLFFSRSKHSDCE--ELLVANTAAHIIRLMLTY 555
Cdd:cd04378  169 GPTLIRPRPGDADVSlsSLVDYGYQARLVEFLITN 203
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 373-526 9.72e-09

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 55.50  E-value: 9.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564370116 373 RKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDArfNTDKFKWDKMCH--REAAVMLKAFFRELP 450
Cdd:cd04383   10 YIQDSGQAIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFER--GEDPLADDQNDHdiNSVAGVLKLYFRGLE 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564370116 451 TSLFPIEYipaFISLMERGPDIKVQFQALHL--MVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNISTVMAPNL 526
Cdd:cd04383   88 NPLFPKER---FEDLMSCVKLENPTERVHQIreILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGPTL 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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