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Conserved domains on  [gi|564364371|ref|XP_006243391|]
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dynein axonemal assembly factor 4 isoform X1 [Rattus norvegicus]

Protein Classification

p23_DYX1C1_like and 3a0801s09 domain-containing protein( domain architecture ID 10158101)

protein containing domains p23_DYX1C1_like, PTZ00121, and 3a0801s09

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
p23_DYX1C1_like cd06469
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) ...
 10-87 1.78e-36

p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region.


:

Pssm-ID: 107226  Cd Length: 78  Bit Score: 127.00  E-value: 1.78e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564364371  10 WQQTPAALFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFEVFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWESLS 87
Cdd:cd06469    1 WSQTDEDVKISVPLKGVKTSKVDIFCSDLYLKVNFPPYLFELDLAAPIDDEKSSAKIGNGVLVFTLVKKEPGIWEALC 78
3a0801s09 super family cl36792
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 251-351 2.30e-10

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00990:

Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 61.92  E-value: 2.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364371  251 ESQVAEEEEWLHKQAEARRAMSTDLPEFSD---LKEEEKN--PDWLKDKGNKLFATENYLAAIDAYNLAIRLnRKIPVLY 325
Cdd:TIGR00990  85 EGKTEEKKSTAPKNAPVEPADELPEIDESSvanLSEEERKkyAAKLKEKGNKAYRNKDFNKAIKLYSKAIEC-KPDPVYY 163

                          90       100
                  ....*....|....*....|....*.
gi 564364371  326 LNRAACHLKLKNLHKAIEDSSKACKI 351
Cdd:TIGR00990 164 SNRAACHNALGDWEKVVEDTTAALEL 189
 
Name Accession Description Interval E-value
p23_DYX1C1_like cd06469
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) ...
 10-87 1.78e-36

p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region.


Pssm-ID: 107226  Cd Length: 78  Bit Score: 127.00  E-value: 1.78e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564364371  10 WQQTPAALFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFEVFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWESLS 87
Cdd:cd06469    1 WSQTDEDVKISVPLKGVKTSKVDIFCSDLYLKVNFPPYLFELDLAAPIDDEKSSAKIGNGVLVFTLVKKEPGIWEALC 78
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 251-351 2.30e-10

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 61.92  E-value: 2.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364371  251 ESQVAEEEEWLHKQAEARRAMSTDLPEFSD---LKEEEKN--PDWLKDKGNKLFATENYLAAIDAYNLAIRLnRKIPVLY 325
Cdd:TIGR00990  85 EGKTEEKKSTAPKNAPVEPADELPEIDESSvanLSEEERKkyAAKLKEKGNKAYRNKDFNKAIKLYSKAIEC-KPDPVYY 163

                          90       100
                  ....*....|....*....|....*.
gi 564364371  326 LNRAACHLKLKNLHKAIEDSSKACKI 351
Cdd:TIGR00990 164 SNRAACHNALGDWEKVVEDTTAALEL 189
CS pfam04969
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ...
 7-77 4.59e-07

CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2.


Pssm-ID: 461503  Cd Length: 76  Bit Score: 46.87  E-value: 4.59e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564364371    7 EFSWQQTPAALFLSLPLRGVCVRDADVFC--GESYLKVNFP--PFLFEVFLYAPIDDGKSKAKIGNDTILFTLYK 77
Cdd:pfam04969   2 RYDWYQTLDEVTITIPVKGAGIKKKDVKVniKPRSLKVKIKggYELIDGELFHPIDPEESSWTIEGKKVEITLKK 76
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 291-357 1.05e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 47.09  E-value: 1.05e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564364371 291 LKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKACKI----MKLHLR 357
Cdd:PLN03088   5 LEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELdpslAKAYLR 75
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
281-351 1.72e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.77  E-value: 1.72e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564364371 281 LKEEEKNPDWLKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKACKI 351
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL 71
 
Name Accession Description Interval E-value
p23_DYX1C1_like cd06469
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) ...
 10-87 1.78e-36

p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region.


Pssm-ID: 107226  Cd Length: 78  Bit Score: 127.00  E-value: 1.78e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564364371  10 WQQTPAALFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFEVFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWESLS 87
Cdd:cd06469    1 WSQTDEDVKISVPLKGVKTSKVDIFCSDLYLKVNFPPYLFELDLAAPIDDEKSSAKIGNGVLVFTLVKKEPGIWEALC 78
p23_like cd06463
Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) ...
 10-86 1.02e-14

Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis. Both p23 and Sba1p can regulate telomerase activity. This group includes domains similar to the C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1). Sgt1 interacts with multiple protein complexes and has the features of a co-chaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. This group also includes the p23_like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). hB-ind1 plays a role in the signaling pathway mediated by the small GTPase Rac1, NUDC is needed for nuclear movement, Melusin interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


Pssm-ID: 107220  Cd Length: 84  Bit Score: 68.85  E-value: 1.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364371  10 WQQTPAALFLSLPLRGVCVRDADVFCGESYLKVNF-----PPFLFEVFLYAPIDDGKSKAKIGNDTILFTLYKKEP-VLW 83
Cdd:cd06463    1 WYQTLDEVTITIPLKDVTKKDVKVEFTPKSLTVSVkggggKEYLLEGELFGPIDPEESKWTVEDRKIEITLKKKEPgEWW 80


                 ...
gi 564364371  84 ESL 86
Cdd:cd06463   81 PRL 83
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 251-351 2.30e-10

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 61.92  E-value: 2.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364371  251 ESQVAEEEEWLHKQAEARRAMSTDLPEFSD---LKEEEKN--PDWLKDKGNKLFATENYLAAIDAYNLAIRLnRKIPVLY 325
Cdd:TIGR00990  85 EGKTEEKKSTAPKNAPVEPADELPEIDESSvanLSEEERKkyAAKLKEKGNKAYRNKDFNKAIKLYSKAIEC-KPDPVYY 163

                          90       100
                  ....*....|....*....|....*.
gi 564364371  326 LNRAACHLKLKNLHKAIEDSSKACKI 351
Cdd:TIGR00990 164 SNRAACHNALGDWEKVVEDTTAALEL 189
p23_CS_SGT1_like cd06466
p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 ...
 10-86 3.83e-08

p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. ScSgt1 is needed for the G1/S and G2/M cell-cycle transitions, and for assembly of the core kinetochore complex (CBF3) via activation of Ctf13, the F-box protein. Binding of Hsp82 (a yeast Hsp90 homologue) to ScSgt1, promotes the binding of Sgt1 to Skp1 and of Skp1 to Ctf13. Some proteins in this group have an SGT1-specific (SGS) domain at the extreme C-terminus. The ScSgt1-SGS domain binds adenylate cyclase. The hSgt1-SGS domain interacts with some S100 family proteins, and studies suggest that the interaction of hSgt1 with Hsp90 and Hsp70 may be regulated by S100A6 in a Ca2+ dependent fashion. This group also includes the p23_like domains of Melusin and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). Melusin is a vertebrate protein which interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


Pssm-ID: 107223  Cd Length: 84  Bit Score: 50.28  E-value: 3.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364371  10 WQQTPAALFLSLPLRGVCVRDADVFCGESYLKVNFP-----PFLFEVFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWE 84
Cdd:cd06466    2 WYQTDTSVTVTIYAKNVDKEDVKVEFNEQSLSVSIIlpggsEYQLELDLFGPIDPEQSKVSVLPTKVEITLKKAEPGSWP 81


                 ..
gi 564364371  85 SL 86
Cdd:cd06466   82 SL 83
CS pfam04969
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ...
 7-77 4.59e-07

CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2.


Pssm-ID: 461503  Cd Length: 76  Bit Score: 46.87  E-value: 4.59e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564364371    7 EFSWQQTPAALFLSLPLRGVCVRDADVFC--GESYLKVNFP--PFLFEVFLYAPIDDGKSKAKIGNDTILFTLYK 77
Cdd:pfam04969   2 RYDWYQTLDEVTITIPVKGAGIKKKDVKVniKPRSLKVKIKggYELIDGELFHPIDPEESSWTIEGKKVEITLKK 76
ACD_sHsps_p23-like cd00298
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small ...
 10-77 3.79e-06

This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this family is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).


Pssm-ID: 107219  Cd Length: 80  Bit Score: 44.50  E-value: 3.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364371  10 WQQTPAALFLSLPLRGVCVRDADVFCGESYLKV------------NFPPFLFEVFLYAPIDDGKSKAKIGNDTILFTLYK 77
Cdd:cd00298    1 WYQTDDEVVVTVDLPGVKKEDIKVEVEDNVLTIsgkreeeeererSYGEFERSFELPEDVDPEKSKASLENGVLEITLPK 80
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 291-357 1.05e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 47.09  E-value: 1.05e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564364371 291 LKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKACKI----MKLHLR 357
Cdd:PLN03088   5 LEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELdpslAKAYLR 75
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
281-351 1.72e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.77  E-value: 1.72e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564364371 281 LKEEEKNPDWLKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKACKI 351
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL 71
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
264-348 2.33e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 44.91  E-value: 2.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364371 264 QAEARRAMSTDLPEFSDLKEEEKNPDW---LKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHK 340
Cdd:COG4785   46 LALAAAALAAAALAAERIDRALALPDLaqlYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDA 125


                 ....*...
gi 564364371 341 AIEDSSKA 348
Cdd:COG4785  126 ALEDFDRA 133
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
281-351 3.08e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.00  E-value: 3.08e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564364371 281 LKEEEKNPDWLKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKACKI 351
Cdd:COG0457   69 LELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALEL 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
285-351 3.69e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.61  E-value: 3.69e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364371 285 EKNPDW---LKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKACKI 351
Cdd:COG0457   36 ELDPDDaeaLYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALEL 105
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
281-353 7.16e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 43.75  E-value: 7.16e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564364371 281 LKEEEKNPDWLKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKACKIMK 353
Cdd:COG4785  100 LELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDP 172
p23_CacyBP cd06468
p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP) ...
 5-86 1.03e-04

p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter two are components of the ubiquitin ligase that regulates beta-catenin degradation. The beta-catenin gene is an oncogene participating in tumorigenesis in many different cancers. Overexpression of CacyBP/SIP, in part through its effect on the expression of beta-catenin, inhibits the proliferation, tumorigenicity, and invasion of gastric cancer cells. CacyBP/SIP is abundant in neurons and neuroblastoma NB2a cells. An extensive re-organization of microtubules accompanies the differentiation of NB2a cells. CacyBP/SIP may contribute to NB2a cell differentiation through binding to and increasing the oligomerization of tubulin. CacyBP/SIP is also implicated in differentiation of erythroid cells, rat neonatal cardiomyocytes, in mouse endometrial events, and in thymocyte development.


Pssm-ID: 107225  Cd Length: 92  Bit Score: 40.71  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364371   5 VSEFSWQQTPAALFLSLPLRGVcvrdadVFCGESYLKVNFPPFLFEVF---------------LYAPIDDGKSKAKIGND 69
Cdd:cd06468    1 ITKYAWDQSDKFVKIYITLKGV------HQLPKENIQVEFTERSFELKvhdlngknyrftinrLLKKIDPEKSSFKVKTD 74

                         90
                 ....*....|....*..
gi 564364371  70 TILFTLYKKEPVLWESL 86
Cdd:cd06468   75 RIVITLAKKKEKKWESL 91
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
281-366 5.07e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 5.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364371 281 LKEEEKNPDWLKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKACKIMKLHLRSTQ 360
Cdd:COG0457  103 LELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAA 182


                 ....*.
gi 564364371 361 PTQLYR 366
Cdd:COG0457  183 LGEAAL 188
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 287-351 1.00e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.13  E-value: 1.00e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564364371 287 NPDWLKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKACKI 351
Cdd:COG3914  145 FAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALEL 209
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 298-351 3.23e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.02  E-value: 3.23e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564364371 298 LFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKACKI 351
Cdd:COG5010   64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALAL 117
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 281-354 4.29e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 37.63  E-value: 4.29e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564364371 281 LKEEEKNPDWLKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKACKIMKL 354
Cdd:COG5010   81 LQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSPL 154
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 281-357 7.83e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 37.79  E-value: 7.83e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564364371 281 LKEEEKNPDWLKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKACKIMKLHLR 357
Cdd:COG2956  103 LELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCAR 179
p23_hB-ind1_like cd06465
p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. ...
 7-86 8.93e-03

p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) kappaB and activation of c-Jun N-terminal kinase (JNK). hB-ind1 also plays a part in the RNA replication and particle production of Hepatitis C virus (HCV) through its interaction with heat shock protein Hsp90, HCV nonstructural protein 5A (NS5A), and the immunophilin FKBP8. hB-ind1 is upregulated in the outer layer of Chinese hamster V79 cells grown as multicell spheroids, versus in the same cells grown as monolayers. This group includes the Saccharomyces cerevisiae Sba1, a co-chaperone of the Hsp90. Sba1 has been shown to be is required for telomere length maintenance, and may modulate telomerase DNA-binding activity.


Pssm-ID: 107222 [Multi-domain]  Cd Length: 108  Bit Score: 35.65  E-value: 8.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364371   7 EFSWQQTPAALFLSLPLRgvCVRDADVFCGESYLKV------NFPPFLFEVFLYAPIDDGKSKAKIGNDTILFTLYKKEP 80
Cdd:cd06465    2 PVLWAQRSDVVYLTIELP--DAKDPKIKLEPTSLSFkakgggGGKKYEFDLEFYKEIDPEESKYKVTGRQIEFVLRKKEA 79


                 ....*..
gi 564364371  81 -VLWESL 86
Cdd:cd06465   80 gEYWPRL 86
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 247-351 9.05e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 38.05  E-value: 9.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364371 247 TALRESQVAEEEEWLHKQAEARRAMSTDLPEFSDLKEEEK-----------NPDW---LKDKGNKLFATENYLAAIDAYN 312
Cdd:COG3914   57 AALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEalalyrralalNPDNaeaLFNLGNLLLALGRLEEALAALR 136

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 564364371 313 LAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKACKI 351
Cdd:COG3914  137 RALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALEL 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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