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Conserved domains on  [gi|564364293|ref|XP_006243359|]
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ubiquitin-associated protein 1-like [Rattus norvegicus]

Protein Classification

ubiquitin-associated protein 1-like( domain architecture ID 13243376)

ubiquitin-associated protein 1-like (UBAP1L)

Gene Ontology:  GO:0043162|GO:0043130|GO:0000813
PubMed:  19468686

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBA2_UBAP1_like cd14316
UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, ...
 340-376 3.21e-14

UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA2 domain.


:

Pssm-ID: 270501  Cd Length: 37  Bit Score: 66.01  E-value: 3.21e-14
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 564364293 340 FLRLWQQFSDMGFQQDRIKEVLLVHGNQREQALEELV 376
Cdd:cd14316    1 FLKLLNQLHELGFPEDKIKEALLKHNNDRDKALDELV 37
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
161-260 1.01e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364293 161 ADARRRLSESRLATSPRALLHRFRAHRTLSLSASPAPTPGPAlQPPNVSELPPRPSTAGAMPPLRShkPTVASLSPYTCL 240
Cdd:PRK12323 420 AAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAA-ARPAAAGPRPVAAAAAAAPARAA--PAAAPAPADDDP 496

                         90       100
                 ....*....|....*....|
gi 564364293 241 PPLRETPQPLASCRLHPDSA 260
Cdd:PRK12323 497 PPWEELPPEFASPAPAQPDA 516
PHA03269 super family cl29788
envelope glycoprotein C; Provisional
 194-345 3.32e-03

envelope glycoprotein C; Provisional


The actual alignment was detected with superfamily member PHA03269:

Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 39.33  E-value: 3.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364293 194 SPAPT------PGPALQPPNVSELPPRPSTAGAMPPLRSHKPTVASLSPYTCLPPLRETPQPLASCRlhPDSAPDLLSAL 267
Cdd:PHA03269  43 APAPHqaasraPDPAVAPTSAASRKPDLAQAPTPAASEKFDPAPAPHQAASRAPDPAVAPQLAAAPK--PDAAEAFTSAA 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364293 268 TKEEQDLIRPVVALG-----------------YPLGRAIVALQKTGRQSLSQFLGYLSACERLLRQGYDEALVDEAMEMF 330
Cdd:PHA03269 121 QAHEAPADAGTSAASkkpdpaahtqhspppfaYTRSMEHIACTHGGIQFIPYFHKFILPCYLQIFTGQGAAFKQHELPKT 200

                        170
                 ....*....|....*..
gi 564364293 331 --QFSEHQAGEFLRLWQ 345
Cdd:PHA03269 201 yeEDFLDPEGANITRWK 217
 
Name Accession Description Interval E-value
UBA2_UBAP1_like cd14316
UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, ...
 340-376 3.21e-14

UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA2 domain.


Pssm-ID: 270501  Cd Length: 37  Bit Score: 66.01  E-value: 3.21e-14
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 564364293 340 FLRLWQQFSDMGFQQDRIKEVLLVHGNQREQALEELV 376
Cdd:cd14316    1 FLKLLNQLHELGFPEDKIKEALLKHNNDRDKALDELV 37
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
161-260 1.01e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364293 161 ADARRRLSESRLATSPRALLHRFRAHRTLSLSASPAPTPGPAlQPPNVSELPPRPSTAGAMPPLRShkPTVASLSPYTCL 240
Cdd:PRK12323 420 AAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAA-ARPAAAGPRPVAAAAAAAPARAA--PAAAPAPADDDP 496

                         90       100
                 ....*....|....*....|
gi 564364293 241 PPLRETPQPLASCRLHPDSA 260
Cdd:PRK12323 497 PPWEELPPEFASPAPAQPDA 516
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 194-345 3.32e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 39.33  E-value: 3.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364293 194 SPAPT------PGPALQPPNVSELPPRPSTAGAMPPLRSHKPTVASLSPYTCLPPLRETPQPLASCRlhPDSAPDLLSAL 267
Cdd:PHA03269  43 APAPHqaasraPDPAVAPTSAASRKPDLAQAPTPAASEKFDPAPAPHQAASRAPDPAVAPQLAAAPK--PDAAEAFTSAA 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364293 268 TKEEQDLIRPVVALG-----------------YPLGRAIVALQKTGRQSLSQFLGYLSACERLLRQGYDEALVDEAMEMF 330
Cdd:PHA03269 121 QAHEAPADAGTSAASkkpdpaahtqhspppfaYTRSMEHIACTHGGIQFIPYFHKFILPCYLQIFTGQGAAFKQHELPKT 200

                        170
                 ....*....|....*..
gi 564364293 331 --QFSEHQAGEFLRLWQ 345
Cdd:PHA03269 201 yeEDFLDPEGANITRWK 217
 
Name Accession Description Interval E-value
UBA2_UBAP1_like cd14316
UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, ...
 340-376 3.21e-14

UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA2 domain.


Pssm-ID: 270501  Cd Length: 37  Bit Score: 66.01  E-value: 3.21e-14
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 564364293 340 FLRLWQQFSDMGFQQDRIKEVLLVHGNQREQALEELV 376
Cdd:cd14316    1 FLKLLNQLHELGFPEDKIKEALLKHNNDRDKALDELV 37
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
161-260 1.01e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364293 161 ADARRRLSESRLATSPRALLHRFRAHRTLSLSASPAPTPGPAlQPPNVSELPPRPSTAGAMPPLRShkPTVASLSPYTCL 240
Cdd:PRK12323 420 AAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAA-ARPAAAGPRPVAAAAAAAPARAA--PAAAPAPADDDP 496

                         90       100
                 ....*....|....*....|
gi 564364293 241 PPLRETPQPLASCRLHPDSA 260
Cdd:PRK12323 497 PPWEELPPEFASPAPAQPDA 516
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 194-345 3.32e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 39.33  E-value: 3.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364293 194 SPAPT------PGPALQPPNVSELPPRPSTAGAMPPLRSHKPTVASLSPYTCLPPLRETPQPLASCRlhPDSAPDLLSAL 267
Cdd:PHA03269  43 APAPHqaasraPDPAVAPTSAASRKPDLAQAPTPAASEKFDPAPAPHQAASRAPDPAVAPQLAAAPK--PDAAEAFTSAA 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364293 268 TKEEQDLIRPVVALG-----------------YPLGRAIVALQKTGRQSLSQFLGYLSACERLLRQGYDEALVDEAMEMF 330
Cdd:PHA03269 121 QAHEAPADAGTSAASkkpdpaahtqhspppfaYTRSMEHIACTHGGIQFIPYFHKFILPCYLQIFTGQGAAFKQHELPKT 200

                        170
                 ....*....|....*..
gi 564364293 331 --QFSEHQAGEFLRLWQ 345
Cdd:PHA03269 201 yeEDFLDPEGANITRWK 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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