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Conserved domains on  [gi|564363561|ref|XP_006243066|]
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tetratricopeptide repeat protein 12 isoform X1 [Rattus norvegicus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
123-224 2.77e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.42  E-value: 2.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 123 LADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAH 202
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100
                 ....*....|....*....|..
gi 564363561 203 LALKNYSKSKECYQKIGEINPK 224
Cdd:COG0457   87 QALGRYEEALEDYDKALELDPD 108
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
123-224 2.77e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.42  E-value: 2.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 123 LADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAH 202
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100
                 ....*....|....*....|..
gi 564363561 203 LALKNYSKSKECYQKIGEINPK 224
Cdd:COG0457   87 QALGRYEEALEDYDKALELDPD 108
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 123-273 1.26e-12

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 69.82  E-value: 1.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 123 LADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAH 202
Cdd:PLN03088   1 MAKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTAC 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564363561 203 LALKNYSKSKECYQKIGEI---NPKLKAQVKEhLNQVTLREKADLQEKK--ARESLDSGKNTAMTTRNLLETLSKP 273
Cdd:PLN03088  81 MKLEEYQTAKAALEKGASLapgDSRFTKLIKE-CDEKIAEEEKDLVQPVpsDLPSSVTAPPVEEADATPVVPPSKP 155
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 68-255 5.54e-11

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 65.78  E-value: 5.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561   68 EREQEEDGCRTTLNKTMISPPQAPENAN----EMNPDAFLASVEKDAKErakrrrENRVLADALKEKGNEAFVKGDYETA 143
Cdd:TIGR00990  73 ERRKRKQAEKETEGKTEEKKSTAPKNAPvepaDELPEIDESSVANLSEE------ERKKYAAKLKEKGNKAYRNKDFNKA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561  144 IFFYSEGLgKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTK-------AYFHMGKAHLALKNYSKSkeCYq 216
Cdd:TIGR00990 147 IKLYSKAI-ECKPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKalnrranAYDGLGKYADALLDLTAS--CI- 222

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 564363561  217 kIGEINPKLKAQVKEHLnqvtLREKAdlqEKKARESLDS 255
Cdd:TIGR00990 223 -IDGFRNEQSAQAVERL----LKKFA---ESKAKEILET 253
TPR_1 pfam00515
Tetratricopeptide repeat;
161-191 2.96e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 41.25  E-value: 2.96e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 564363561  161 YTNRAQAYIKLGDYQKALVDCDWALKCDENC 191
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 161-191 3.61e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 41.28  E-value: 3.61e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 564363561   161 YTNRAQAYIKLGDYQKALVDCDWALKCDENC 191
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
123-224 2.77e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.42  E-value: 2.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 123 LADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAH 202
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100
                 ....*....|....*....|..
gi 564363561 203 LALKNYSKSKECYQKIGEINPK 224
Cdd:COG0457   87 QALGRYEEALEDYDKALELDPD 108
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 123-273 1.26e-12

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 69.82  E-value: 1.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 123 LADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAH 202
Cdd:PLN03088   1 MAKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTAC 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564363561 203 LALKNYSKSKECYQKIGEI---NPKLKAQVKEhLNQVTLREKADLQEKK--ARESLDSGKNTAMTTRNLLETLSKP 273
Cdd:PLN03088  81 MKLEEYQTAKAALEKGASLapgDSRFTKLIKE-CDEKIAEEEKDLVQPVpsDLPSSVTAPPVEEADATPVVPPSKP 155
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 68-255 5.54e-11

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 65.78  E-value: 5.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561   68 EREQEEDGCRTTLNKTMISPPQAPENAN----EMNPDAFLASVEKDAKErakrrrENRVLADALKEKGNEAFVKGDYETA 143
Cdd:TIGR00990  73 ERRKRKQAEKETEGKTEEKKSTAPKNAPvepaDELPEIDESSVANLSEE------ERKKYAAKLKEKGNKAYRNKDFNKA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561  144 IFFYSEGLgKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTK-------AYFHMGKAHLALKNYSKSkeCYq 216
Cdd:TIGR00990 147 IKLYSKAI-ECKPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKalnrranAYDGLGKYADALLDLTAS--CI- 222

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 564363561  217 kIGEINPKLKAQVKEHLnqvtLREKAdlqEKKARESLDS 255
Cdd:TIGR00990 223 -IDGFRNEQSAQAVERL----LKKFA---ESKAKEILET 253
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
100-255 1.28e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 61.85  E-value: 1.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 100 DAFLASVEKDAKERAKRRRENRVLADALKEKGNEAFVKGDYETAIFFYSEGLgKLK-DMKVLYTNRAQAYIKLGDYQKAL 178
Cdd:COG4785   49 AAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQAL-ELDpDLAEAYNNRGLAYLLLGDYDAAL 127

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564363561 179 VDCDWALKCDENCTKAYFHMGKAHLALKNYSKSKECYQKIGEINPKLKAQV-KEHLNQvtlrekADLQEKKARESLDS 255
Cdd:COG4785  128 EDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERAlWLYLAE------RKLDPEKALALLLE 199
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
124-251 2.83e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.18  E-value: 2.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 124 ADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHL 203
Cdd:COG0457   76 AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALE 155

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564363561 204 ALKNYSKSKECYQKIGEINPKLKAQVKEHLNQVTLREKADLQEKKARE 251
Cdd:COG0457  156 KLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLAL 203
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 110-235 1.11e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.94  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 110 AKERAKRRRENrvlADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDE 189
Cdd:COG4235    6 LRQALAANPND---AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDP 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564363561 190 NCTKAYFHMGKAHLALKNYSKSKECYQKIGEINPK--LKAQVKEHLNQ 235
Cdd:COG4235   83 DNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPAdaPARLLEASIAE 130
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 124-255 3.94e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.20  E-value: 3.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 124 ADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHL 203
Cdd:COG2956  110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYL 189

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564363561 204 ALKNYSKSKECYQKIGEINPKlKAQVKEHLNQVTLREKadlQEKKARESLDS 255
Cdd:COG2956  190 EQGDYEEAIAALERALEQDPD-YLPALPRLAELYEKLG---DPEEALELLRK 237
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 124-224 4.66e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.20  E-value: 4.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 124 ADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHL 203
Cdd:COG4783   38 PEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYR 117

                         90       100
                 ....*....|....*....|.
gi 564363561 204 ALKNYSKSKECYQKIGEINPK 224
Cdd:COG4783  118 ALGRPDEAIAALEKALELDPD 138
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 84-223 7.42e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 55.35  E-value: 7.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561  84 MISPPQAPENANEMNPDAFLASVEKDAKERAKRRRENRVLADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTN 163
Cdd:COG5010   14 LLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYN 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 164 RAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHLALKNYSKSKECYQKIGEINP 223
Cdd:COG5010   94 LALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 124-224 7.78e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.81  E-value: 7.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 124 ADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHL 203
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALL 83

                         90       100
                 ....*....|....*....|.
gi 564363561 204 ALKNYSKSKECYQKIGEINPK 224
Cdd:COG4783   84 KAGDYDEALALLEKALKLDPE 104
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 124-224 9.26e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.85  E-value: 9.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 124 ADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHL 203
Cdd:COG3914  112 AEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQ 191

                         90       100
                 ....*....|....*....|.
gi 564363561 204 ALKNYSKSKECYQKIGEINPK 224
Cdd:COG3914  192 DLGRLEEAIAAYRRALELDPD 212
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
137-225 1.69e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 52.48  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 137 KGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALvDCDWALKCDENCTKAYFHMGKAHLALKNYSKSKECYQ 216
Cdd:COG3063    5 LGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLE 83


                 ....*....
gi 564363561 217 KIGEINPKL 225
Cdd:COG3063   84 RALELDPSA 92
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 112-224 1.62e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.19  E-value: 1.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 112 ERAKRRRENRvlADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENC 191
Cdd:COG2956   66 QKLLERDPDR--AEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN 143

                         90       100       110
                 ....*....|....*....|....*....|...
gi 564363561 192 TKAYFHMGKAHLALKNYSKSKECYQKIGEINPK 224
Cdd:COG2956  144 AHAYCELAELYLEQGDYDEAIEALEKALKLDPD 176
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 108-223 2.84e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 2.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 108 KDAKERAKR-RRENRVLADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALK 186
Cdd:COG2956  127 EKAIEVLERlLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564363561 187 CDENCTKAYFHMGKAHLALKNYSKSKECYQKIGEINP 223
Cdd:COG2956  207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDP 243
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 124-254 3.47e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.42  E-value: 3.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 124 ADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHL 203
Cdd:COG2956   42 VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYE 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564363561 204 ALKNYSKSKECYQKIGEINPKlKAQVKEHLNQVTLREKadlQEKKARESLD 254
Cdd:COG2956  122 QEGDWEKAIEVLERLLKLGPE-NAHAYCELAELYLEQG---DYDEAIEALE 168
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
84-224 7.19e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 50.68  E-value: 7.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561  84 MISPPQAPENANEMNPDAFLASVEKDAKERAKRrreNRVLADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYtN 163
Cdd:COG4785    3 ALALALLLALALAAAAASKAAILLAALLFAAVL---ALAIALADLALALAAAALAAAALAAERIDRALALPDLAQLYY-E 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564363561 164 RAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHLALKNYSKSKECYQKIGEINPK 224
Cdd:COG4785   79 RGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 84-246 1.73e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.53  E-value: 1.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561  84 MISPPQAPENANEMNPDAFLASVEKDAKERAKRRRENRVLADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTN 163
Cdd:COG3914    4 AALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLEL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 164 RAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHLALKNYSKSKECYQKIGEINPKLkAQVkeHLNQ-VTLREKA 242
Cdd:COG3914   84 AALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDF-AEA--YLNLgEALRRLG 160


                 ....
gi 564363561 243 DLQE 246
Cdd:COG3914  161 RLEE 164
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 123-223 6.96e-06

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 49.21  E-value: 6.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561  123 LADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAH 202
Cdd:TIGR00990 330 EAIALNLRGTFKCLKGKHLEALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLH 409

                          90       100
                  ....*....|....*....|.
gi 564363561  203 LALKNYSKSKECYQKIGEINP 223
Cdd:TIGR00990 410 FIKGEFAQAGKDYQKSIDLDP 430
TPR_1 pfam00515
Tetratricopeptide repeat;
161-191 2.96e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 41.25  E-value: 2.96e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 564363561  161 YTNRAQAYIKLGDYQKALVDCDWALKCDENC 191
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 161-191 3.61e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 41.28  E-value: 3.61e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 564363561   161 YTNRAQAYIKLGDYQKALVDCDWALKCDENC 191
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 123-254 1.24e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.03  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 123 LADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAH 202
Cdd:COG5010   19 KLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLY 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564363561 203 LALKNYSKSKECYQKIGEINPKLkAQVKEHLNQVTLREKadlQEKKARESLD 254
Cdd:COG5010   99 SRSGDKDEAKEYYEKALALSPDN-PNAYSNLAALLLSLG---QDDEAKAALQ 146
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 129-254 3.49e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.18  E-value: 3.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 129 EKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHLALKNY 208
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLL 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 564363561 209 SKSKECYQKIGEINPKlKAQVKEHLNQVTLREKadlQEKKARESLD 254
Cdd:COG2956   93 DRAEELLEKLLELDPD-DAEALRLLAEIYEQEG---DWEKAIEVLE 134
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 133-218 8.44e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.59  E-value: 8.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 133 EAFVKGDYETAIFFYSEGLGKLKDMKVL---YTNRAQAYIKLGDYQKALVDCDWALKCDENCTK---AYFHMGKAHLALK 206
Cdd:COG1729    2 ALLKAGDYDEAIAAFKAFLKRYPNSPLApdaLYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLELG 81

                         90
                 ....*....|..
gi 564363561 207 NYSKSKECYQKI 218
Cdd:COG1729   82 DYDKARATLEEL 93
TPR_1 pfam00515
Tetratricopeptide repeat;
193-224 1.33e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.63  E-value: 1.33e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 564363561  193 KAYFHMGKAHLALKNYSKSKECYQKIGEINPK 224
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 70-223 2.76e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561   70 EQEEDGCRTTLNKTMISPP--------QAPENANEMNPDAFLASVEKDAKERAKRRRENRVLADALKEKGNEAFVKGDYE 141
Cdd:TIGR02917 478 KGDLAKAREAFEKALSIEPdffpaaanLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLE 557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561  142 TAIffyseglGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHLALKNYSKSKECYQKIGEI 221
Cdd:TIGR02917 558 KAA-------ELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLAL 630


                  ..
gi 564363561  222 NP 223
Cdd:TIGR02917 631 QP 632
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
167-254 2.81e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564363561 167 AYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHLALKNYSKSKEcYQKIGEINPKlKAQVKEHLNQVTLREKadlQE 246
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPN-NAEALLNLAELLLELG---DY 75


                 ....*...
gi 564363561 247 KKARESLD 254
Cdd:COG3063   76 DEALAYLE 83
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 193-224 3.95e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.19  E-value: 3.95e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 564363561  193 KAYFHMGKAHLALKNYSKSKECYQKIGEINPK 224
Cdd:pfam07719   2 EALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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