Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 564362920  395 NLKQHMLIHSGIKPFQCDCCGKKFTR 420
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

outer membrane protein PgaA; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920 203 NSPQVLnSSASYAENRNQPVDSSL--AFPWTFPFGIDRRIQPEKAkqAENTRTLELPGPSE------AGRRMADYVTCES 274
Cdd:PRK10049 148 QTQQYP-TEYVQALRNNRLSAPALgaIDDANLTPAEKRDLEADAA--AELVRLSFMPTRSEkeryaiADRALAQYDALEA 224

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564362920 275 TKTTLPLGTEEDVRVKVERLSDEEVHEEVSQPVSASQSSLSDQQTVPG 322
Cdd:PRK10049 225 LWHDNPDATADYQRARIDRLGALLARDRYKDVISEYQRLKAEGQIIPP 272

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920   21 LNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENKNVLDLHHVTVTGFIPLLEYAYTATLsINTEN 100
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 564362920  101 IIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  22 NMLRNDGHFCD--ITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENKNVLDLHHVtvtgFIPLLEYAYTATLSINTE 99
Cdd:PHA03098   1 MYSFELQKFCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINLNIDYDS----FNEVIKYIYTGKINITSN 76

                         90       100
                 ....*....|....*....|....*
gi 564362920 100 NIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:PHA03098  77 NVKDILSIANYLIIDFLINLCINYI 101

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920 351 PTLQSTSSTNAHADEDDSTE-RPSPNGPDRPFQCPTCGVRFTRIQNLKQHMLIHSGIKPFQC--DCCGKKFTRAYSLKMH 427
Cdd:COG5048    3 LTSSQSSSSNNSVLSSTPKStLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRH 82

                 ....
gi 564362920 428 RLKH 431
Cdd:COG5048   83 LRTH 86

outer membrane protein PgaA; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920 203 NSPQVLnSSASYAENRNQPVDSSL--AFPWTFPFGIDRRIQPEKAkqAENTRTLELPGPSE------AGRRMADYVTCES 274
Cdd:PRK10049 148 QTQQYP-TEYVQALRNNRLSAPALgaIDDANLTPAEKRDLEADAA--AELVRLSFMPTRSEkeryaiADRALAQYDALEA 224

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564362920 275 TKTTLPLGTEEDVRVKVERLSDEEVHEEVSQPVSASQSSLSDQQTVPG 322
Cdd:PRK10049 225 LWHDNPDATADYQRARIDRLGALLARDRYKDVISEYQRLKAEGQIIPP 272

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920   21 LNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENKNVLDLHHVTVTGFIPLLEYAYTATLsINTEN 100
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 564362920  101 IIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  30 FCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENKNVLDLHHVTVTGFIPLLEYAYTATLSINTENIIDVLAAAS 109
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80

                 .
gi 564362920 110 Y 110
Cdd:cd18186   81 K 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  31 CDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTeDENKNVLDLHHVTVTGFIPLLEYAYTATLSINTENIIDVLAAASY 110
Cdd:cd18955    2 CDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQT-DGDLVITLPEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEF 80

                         90
                 ....*....|....
gi 564362920 111 MQMFSVASTCSEFM 124
Cdd:cd18955   81 LGVHNIEKACFDFL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  15 QEMLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENKNVLDLHHVTVTGFIPLLEYAYTATL 94
Cdd:cd18242    6 KSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTETV 85

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564362920  95 SINTENIIDVLAAASYMQMFSVASTCSEFMKS 126
Cdd:cd18242   86 HVTVENVQELLPAACLLQLKGVKQACCEFLES 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  17 MLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTeDENKNVLDLHHVTVTGFIPLLEYAYTATLSI 96
Cdd:cd18277   14 VLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQA-DAELNITLPEEVTVKGFEPLIQFAYTAKLIL 92

                         90       100
                 ....*....|....*....|....*...
gi 564362920  97 NTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18277   93 SKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  16 EMLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENKNVLDLHHVTVTGFIPLLEYAYTATLS 95
Cdd:cd18198   11 EILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYTATLT 90

                         90       100       110
                 ....*....|....*....|....*....|
gi 564362920  96 INTENIIDVLAAASYMQMFSVASTCSEFMK 125
Cdd:cd18198   91 VSTANVGDILSAARLLEIPCVSHVCAEILD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  21 LNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTedENKNVLDL-HHVTVTGFIPLLEYAYTATLSINTE 99
Cdd:cd18278   22 LNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQT--ENDLVVSLpEEVTARGFGPLLQFAYTAKLLLSRE 99

                         90       100
                 ....*....|....*....|....*
gi 564362920 100 NIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18278  100 NIQEVIRCAEFLRMHNLEDSCFRFL 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  16 EMLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENKNVLDLHHVTVTGFIPLLEYAYTATLS 95
Cdd:cd18238    1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLT 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 564362920  96 INTENIIDVLAAASYMQMFSVASTCSEFMKS 126
Cdd:cd18238   81 LTVDNVQSLLYAASLLQVEEVAKACCEFMKD 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  15 QEMLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVG-QTEDENKNVLDLHHVTVTGFIPLLEYAYTAT 93
Cdd:cd18230    6 RHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQvQKTSDQATVTHLDIVTAQGFKAIIDFMYSAH 85

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564362920  94 LSINTENIIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:cd18230   86 LALTSKNVIEVMSAASYLQMTDIVQACHNFIKAAL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920   5 TFTHSSSSHSQEMLGKLNMLR-NDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENK-NVLDLHHVTVTGF 82
Cdd:cd18207    1 SYTYQVSQHSADMLHNLNQQRkSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTpRELEMHTISSKVF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 564362920  83 IPLLEYAYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSS 127
Cdd:cd18207   81 GDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQS 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  16 EMLGKLNMLRNDGHFCDITIRV----QDRIFRAHKVVLAACSDFFRTKLVGQTEDENKNVLDLHHVTVTGFIPLLEYAYT 91
Cdd:cd18248    7 EAFQIMNELRLSQQLCDVTLKVkyqdPKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYT 86

                         90       100       110
                 ....*....|....*....|....*....|...
gi 564362920  92 ATLSINTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18248   87 ASISVGEKCVLHVLPGAVMYQMDSVVKACCDFL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  17 MLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQ--TEDENKNVLDLHHVTVTGFIPLLEYAYTATL 94
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNppKDDGSTYKIELEGISVEVMEEILDYIYTGQI 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 564362920  95 SINTENIIDVLAAASYMQMFSVASTCSEFMK 125
Cdd:cd18245   81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  16 EMLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENKNVLDLHHVTVTGFIPLLEYAYTATLS 95
Cdd:cd18328   11 EVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYTSTLT 90

                         90       100
                 ....*....|....*....|....*....
gi 564362920  96 INTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18328   91 ITTSNVKHILNAAQMLEIQCIINVCLEIM 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  21 LNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFR----TKLVGQTEDEnknvldlhhVTVTGFIP-----LLEYAYT 91
Cdd:cd18247   10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHamftHDMVESKQDE---------ITMQGIEPsaleaLINFAYS 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564362920  92 ATLSINTENIIDVLAAASYMQMFSVASTCSEFMKS 126
Cdd:cd18247   81 GRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  16 EMLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRtKLVGQTEDEN--------KNVLDLHHVTVTGFIPLLE 87
Cdd:cd18327   11 ELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFR-KLFTGGGGGSgdlgagggQDVCELDFVGPEALGALLE 89

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 564362920  88 YAYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMK 125
Cdd:cd18327   90 FAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  17 MLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENK-NVLDLHHVTVTGFIPLLEYAYTATLS 95
Cdd:cd18199    5 LLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRpSTASFDVFSSDAFSIILDFVYSGKLS 84

                         90       100
                 ....*....|....*....|....*....
gi 564362920  96 INTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18199   85 LTSQNVIEVMSAASYLQMTDVINVCKTFI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  15 QEMLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENKNVLDLHHVTVTGFIPLLEYAYTATL 94
Cdd:cd18235    6 QKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEI 85

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564362920  95 SINTENIIDVLAAASYMQMFSVASTCSEFMKS 126
Cdd:cd18235   86 QVTEENVQVLLPAANLLQLTDVRDACCDFLQS 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  15 QEMLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENKN-VLDLHHVTVTGFIPLLEYAYTAT 93
Cdd:cd18202    4 QTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEaVVDLSGFCKSSFLPLLEFAYTSE 83

                         90       100
                 ....*....|....*....|....*..
gi 564362920  94 LSINTENIIDVLAAASYMQMFSVASTC 120
Cdd:cd18202   84 LTFDFCSMAEVAMLARHLFMNEVLEIC 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  17 MLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVgqTEDENKNVL-DLHHVTVtgFIPLLEYAYTATLS 95
Cdd:cd18227   12 ILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVL--LKNSRRIVLpDVMNPRV--FENILLSCYTGRLV 87

                         90       100       110
                 ....*....|....*....|....*....|
gi 564362920  96 INTENIIDVLAAASYMQMFSVASTCSEFMK 125
Cdd:cd18227   88 LPAPEIVSYLTAASFLQMWHVVDKCTELLE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  17 MLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENKNVLDLHHVTVTGFIPLLEYAYTATLSI 96
Cdd:cd18264   15 VLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSL 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564362920  97 NTENIIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:cd18264   95 SLDTLEDTLEAASYLQVTEAIGLCSQYLINNL 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  17 MLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEDENKNVLDLHHV-TVTGFIPLLEYAYTATLS 95
Cdd:cd18329    8 LLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVfSPDTFTIILDFVYSGKLS 87

                         90       100
                 ....*....|....*....|....*....
gi 564362920  96 INTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18329   88 LTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362920  16 EMLGKLNMLRNDGHFCDITIRVQDRIFRAHKVVLAACSDFFRTKLVGQTEdENKNVLDLH-HVTVTGFIPLLEYAYTATL 94
Cdd:cd18331   10 DVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLK-CNLSVINLDpEINPEGFNILLDFMYTSRL 88

                         90       100       110
                 ....*....|....*....|....*....|
gi 564362920  95 SINTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18331   89 NLREGNIMAVMATAMYLQMEHVVDTCRKFI 118