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Conserved domains on  [gi|564356720|ref|XP_006240424|]
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HEAT repeat-containing protein 4 isoform X2 [Rattus norvegicus]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 11444215)

HEAT repeat domain-containing protein may function as a scaffold, anchoring and/or adaptor protein

CATH:  1.25.10.110
Gene Ontology:  GO:0005515
PubMed:  35552740|10378263
SCOP:  4001283

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
694-838 2.49e-12

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 65.04  E-value: 2.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356720  694 VRQAAAKALGQMNlGKEVHDMIRIKLCQGNSQERIKALSLIRGLKimTAKLLPSFLTCLSDEFTGIRQAACLAAGalKIR 773
Cdd:COG1413     1 VRRAAARALGRLG-DPAAVPALIAALADEDPDVRAAAARALGRLG--DPRAVPALLEALKDPDPEVRAAAAEALG--RIG 75
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564356720  774 DEMVLERLLNLmLTDPYWKIKAFAIRALGQIGqvSPQLTNNLLWAIHYEDAPgVRLEACRSIQAL 838
Cdd:COG1413    76 DPEAVPALIAA-LKDEDPEVRRAAAEALGRLG--DPAAVPALLEALKDPDWE-VRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
545-705 3.41e-04

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.92  E-value: 3.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356720  545 LSALETALSDSNPNVRMAAAicqYSI-QSHNPTAQDIMETALTKGNSVDSWAAAQCLALAGiatypvikrilhqlfyknn 623
Cdd:COG1413    18 VPALIAALADEDPDVRAAAA---RALgRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIG------------------- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356720  624 eatERQACELLNHLrvnstlihtmlaveLNSRQWRDRIVACRAFSQISGKVCIDmkqKIIQLMwNDWNKEVRQAAAKALG 703
Cdd:COG1413    76 ---DPEAVPALIAA--------------LKDEDPEVRRAAAEALGRLGDPAAVP---ALLEAL-KDPDWEVRRAAARALG 134

                  ..
gi 564356720  704 QM 705
Cdd:COG1413   135 RL 136
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
694-838 2.49e-12

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 65.04  E-value: 2.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356720  694 VRQAAAKALGQMNlGKEVHDMIRIKLCQGNSQERIKALSLIRGLKimTAKLLPSFLTCLSDEFTGIRQAACLAAGalKIR 773
Cdd:COG1413     1 VRRAAARALGRLG-DPAAVPALIAALADEDPDVRAAAARALGRLG--DPRAVPALLEALKDPDPEVRAAAAEALG--RIG 75
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564356720  774 DEMVLERLLNLmLTDPYWKIKAFAIRALGQIGqvSPQLTNNLLWAIHYEDAPgVRLEACRSIQAL 838
Cdd:COG1413    76 DPEAVPALIAA-LKDEDPEVRRAAAEALGRLG--DPAAVPALLEALKDPDWE-VRRAAARALGRL 136
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
680-802 4.88e-08

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 51.57  E-value: 4.88e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356720   680 QKIIQLMWNDWNKEVRQAAAKALGQMNlgkevhdmiriklcqgnsqerikalslirglkimTAKLLPSFLTCLSDEFTGI 759
Cdd:pfam13646    2 PALLQALLRDPDPEVRAAAIRALGRIG----------------------------------DPEAVPALLELLKDEDPAV 47
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 564356720   760 RQAACLAAGalKIRDEMVLERLLNLMLTDPYWKIKAFAIRALG 802
Cdd:pfam13646   48 RRAAAEALG--KIGDPEALPALLELLRDDDDDVVRAAAAEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
545-705 3.41e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.92  E-value: 3.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356720  545 LSALETALSDSNPNVRMAAAicqYSI-QSHNPTAQDIMETALTKGNSVDSWAAAQCLALAGiatypvikrilhqlfyknn 623
Cdd:COG1413    18 VPALIAALADEDPDVRAAAA---RALgRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIG------------------- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356720  624 eatERQACELLNHLrvnstlihtmlaveLNSRQWRDRIVACRAFSQISGKVCIDmkqKIIQLMwNDWNKEVRQAAAKALG 703
Cdd:COG1413    76 ---DPEAVPALIAA--------------LKDEDPEVRRAAAEALGRLGDPAAVP---ALLEAL-KDPDWEVRRAAARALG 134

                  ..
gi 564356720  704 QM 705
Cdd:COG1413   135 RL 136
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
544-573 3.91e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 35.97  E-value: 3.91e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 564356720   544 LLSALETALSDSNPNVRMAAAICQYSIQSH 573
Cdd:pfam02985    1 LLPLLLKLLNDPSPEVREAAAEALGELAEV 30
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
694-838 2.49e-12

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 65.04  E-value: 2.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356720  694 VRQAAAKALGQMNlGKEVHDMIRIKLCQGNSQERIKALSLIRGLKimTAKLLPSFLTCLSDEFTGIRQAACLAAGalKIR 773
Cdd:COG1413     1 VRRAAARALGRLG-DPAAVPALIAALADEDPDVRAAAARALGRLG--DPRAVPALLEALKDPDPEVRAAAAEALG--RIG 75
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564356720  774 DEMVLERLLNLmLTDPYWKIKAFAIRALGQIGqvSPQLTNNLLWAIHYEDAPgVRLEACRSIQAL 838
Cdd:COG1413    76 DPEAVPALIAA-LKDEDPEVRRAAAEALGRLG--DPAAVPALLEALKDPDWE-VRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
660-805 3.56e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 61.95  E-value: 3.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356720  660 RIVACRAFSQISGKVCIDMkqkIIQLMwNDWNKEVRQAAAKALGQMNLGKEVHDMIRIkLCQGNSQERIKALSLIRGLKi 739
Cdd:COG1413     2 RRAAARALGRLGDPAAVPA---LIAAL-ADEDPDVRAAAARALGRLGDPRAVPALLEA-LKDPDPEVRAAAAEALGRIG- 75
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564356720  740 mTAKLLPSFLTCLSDEFTGIRQAACLAAGalKIRDEMVLERLLNLmLTDPYWKIKAFAIRALGQIG 805
Cdd:COG1413    76 -DPEAVPALIAALKDEDPEVRRAAAEALG--RLGDPAAVPALLEA-LKDPDWEVRRAAARALGRLG 137
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
680-802 4.88e-08

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 51.57  E-value: 4.88e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356720   680 QKIIQLMWNDWNKEVRQAAAKALGQMNlgkevhdmiriklcqgnsqerikalslirglkimTAKLLPSFLTCLSDEFTGI 759
Cdd:pfam13646    2 PALLQALLRDPDPEVRAAAIRALGRIG----------------------------------DPEAVPALLELLKDEDPAV 47
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 564356720   760 RQAACLAAGalKIRDEMVLERLLNLMLTDPYWKIKAFAIRALG 802
Cdd:pfam13646   48 RRAAAEALG--KIGDPEALPALLELLRDDDDDVVRAAAAEALA 88
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
778-864 2.12e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 46.95  E-value: 2.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356720   778 LERLLNLMLTDPYWKIKAFAIRALGQIGqvSPQLTNNLLWAIHYEDaPGVRLEACRSIQALNLQgnKVRDTFLDvLLLEK 857
Cdd:pfam13646    1 LPALLQALLRDPDPEVRAAAIRALGRIG--DPEAVPALLELLKDED-PAVRRAAAEALGKIGDP--EALPALLE-LLRDD 74

                   ....*..
gi 564356720   858 HEAVLRE 864
Cdd:pfam13646   75 DDDVVRA 81
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
752-836 3.77e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 46.18  E-value: 3.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356720   752 LSDEFTGIRQAACLAAGalKIRDEMVLERLLNLmLTDPYWKIKAFAIRALGQIGqvSPQLTNNLLWAIHYEDAPGVRLEA 831
Cdd:pfam13646    9 LRDPDPEVRAAAIRALG--RIGDPEAVPALLEL-LKDEDPAVRRAAAEALGKIG--DPEALPALLELLRDDDDDVVRAAA 83

                   ....*
gi 564356720   832 CRSIQ 836
Cdd:pfam13646   84 AEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
545-705 3.41e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.92  E-value: 3.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356720  545 LSALETALSDSNPNVRMAAAicqYSI-QSHNPTAQDIMETALTKGNSVDSWAAAQCLALAGiatypvikrilhqlfyknn 623
Cdd:COG1413    18 VPALIAALADEDPDVRAAAA---RALgRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIG------------------- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356720  624 eatERQACELLNHLrvnstlihtmlaveLNSRQWRDRIVACRAFSQISGKVCIDmkqKIIQLMwNDWNKEVRQAAAKALG 703
Cdd:COG1413    76 ---DPEAVPALIAA--------------LKDEDPEVRRAAAEALGRLGDPAAVP---ALLEAL-KDPDWEVRRAAARALG 134

                  ..
gi 564356720  704 QM 705
Cdd:COG1413   135 RL 136
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
544-573 3.91e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 35.97  E-value: 3.91e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 564356720   544 LLSALETALSDSNPNVRMAAAICQYSIQSH 573
Cdd:pfam02985    1 LLPLLLKLLNDPSPEVREAAAEALGELAEV 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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