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Conserved domains on  [gi|564355916|ref|XP_006240138|]
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striatin-3 isoform X2 [Rattus norvegicus]

Protein Classification

striatin( domain architecture ID 10548818)

striatin, a WD40 repeat protein which may function as scaffolding or signaling protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 425-746 7.62e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 214.51  E-value: 7.62e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 425 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 504
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 505 ATIQWWNMPSPNvdpydtyeshvLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCICTYNGdKEHGIp 584
Cdd:cd00200   73 KTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 585 TSVDFIGCDpaHMVTSF-NTGSAIIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 663
Cdd:cd00200  139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 664 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 743
Cdd:cd00200  210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                 ...
gi 564355916 744 KVF 746
Cdd:cd00200  286 RIW 288
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 64-188 4.44e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


:

Pssm-ID: 462401  Cd Length: 85  Bit Score: 155.74  E-value: 4.44e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916   64 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 143
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 564355916  144 dlkmptfeseetkdaeappaqnsqlTWKQGRQLLRQYLQEVGYTD 188
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 425-746 7.62e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 214.51  E-value: 7.62e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 425 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 504
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 505 ATIQWWNMPSPNvdpydtyeshvLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCICTYNGdKEHGIp 584
Cdd:cd00200   73 KTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 585 TSVDFIGCDpaHMVTSF-NTGSAIIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 663
Cdd:cd00200  139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 664 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 743
Cdd:cd00200  210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                 ...
gi 564355916 744 KVF 746
Cdd:cd00200  286 RIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
385-745 9.01e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 202.06  E-value: 9.01e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 385 LLSVLGLGDLADLTVTNDADYSYDLPANKDALRKTWN-----PKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNL 459
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDlatglLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 460 QKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPNvdpydtyeshvLAGTLVAHTDAV 539
Cdd:COG2319  150 ATG-----------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 540 WGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCICTYNGDkeHGIPTSVDFIGcDPAHMVTSFNTGSAIIYDLETSQSL 617
Cdd:COG2319  208 RSVAFSpdG--KLLASGSADGTVRLWDLATG-KLLRTLTGH--SGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELL 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 618 VMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSI 697
Cdd:COG2319  282 RTLTGHSGG-------VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 564355916 698 RLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKV 745
Cdd:COG2319  355 RLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTLASGSADGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 64-188 4.44e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 155.74  E-value: 4.44e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916   64 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 143
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 564355916  144 dlkmptfeseetkdaeappaqnsqlTWKQGRQLLRQYLQEVGYTD 188
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 662-701 5.13e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 5.13e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564355916   662 TGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 701
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
663-701 9.27e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 9.27e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564355916  663 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 701
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 425-746 7.62e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 214.51  E-value: 7.62e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 425 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 504
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 505 ATIQWWNMPSPNvdpydtyeshvLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCICTYNGdKEHGIp 584
Cdd:cd00200   73 KTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 585 TSVDFIGCDpaHMVTSF-NTGSAIIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 663
Cdd:cd00200  139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 664 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 743
Cdd:cd00200  210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                 ...
gi 564355916 744 KVF 746
Cdd:cd00200  286 RIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
385-745 9.01e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 202.06  E-value: 9.01e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 385 LLSVLGLGDLADLTVTNDADYSYDLPANKDALRKTWN-----PKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNL 459
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDlatglLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 460 QKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPNvdpydtyeshvLAGTLVAHTDAV 539
Cdd:COG2319  150 ATG-----------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 540 WGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCICTYNGDkeHGIPTSVDFIGcDPAHMVTSFNTGSAIIYDLETSQSL 617
Cdd:COG2319  208 RSVAFSpdG--KLLASGSADGTVRLWDLATG-KLLRTLTGH--SGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELL 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 618 VMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSI 697
Cdd:COG2319  282 RTLTGHSGG-------VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 564355916 698 RLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKV 745
Cdd:COG2319  355 RLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTLASGSADGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 64-188 4.44e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 155.74  E-value: 4.44e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916   64 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 143
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 564355916  144 dlkmptfeseetkdaeappaqnsqlTWKQGRQLLRQYLQEVGYTD 188
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 COG2319
WD40 repeat [General function prediction only];
418-704 1.86e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.08  E-value: 1.86e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 418 KTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQ 497
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-----------KLLRTLTGHTGAVRSVAFSPDGKL 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 498 CFSGGIDATIQWWNMPSPNvdpydtyeshvLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPQEKlPCICTYNG 577
Cdd:COG2319  219 LASGSADGTVRLWDLATGK-----------LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTG 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 578 DkeHGIPTSVDFIGcDPAHMVTSFNTGSAIIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKF 657
Cdd:COG2319  287 H--SGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-------VRSVAFSPDGKTLASGSDDGTVRL 356

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564355916 658 FDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDS 704
Cdd:COG2319  357 WDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
425-746 1.46e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.83  E-value: 1.46e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 425 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 504
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-----------ALLATLLGHTAAVLSVAFSPDGRLLASASAD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 505 ATIQWWNMpspnvdpydtyESHVLAGTLVAHTDAVWGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCICTYNGDkeHG 582
Cdd:COG2319  100 GTVRLWDL-----------ATGLLLRTLTGHTGAVRSVAFSpdG--KTLASGSADGTVRLWDLATG-KLLRTLTGH--SG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 583 IPTSVDFIGcDPAHMVTSFNTGSAIIYDLETSQSLVMLSSqvdsglqSSNHINRVVSHP---TLpvtITAHEDRHIKFFD 659
Cdd:COG2319  164 AVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG-------HTGAVRSVAFSPdgkLL---ASGSADGTVRLWD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 660 NKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGA 739
Cdd:COG2319  233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----SGGVNSVAFSPDGKLLASGSD 308


                 ....*..
gi 564355916 740 DALAKVF 746
Cdd:COG2319  309 DGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 528-746 8.21e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.30  E-value: 8.21e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 528 LAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNpQEKLPCICTYngdKEHGIP-TSVDFIGCDPAhMVTSFNTGSA 606
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTL---KGHTGPvRDVAASADGTY-LASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355916 607 IIYDLETSQSLVMLSSqvdsglqssnHINRVVS---HPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDP 683
Cdd:cd00200   76 RLWDLETGECVRTLTG----------HTSYVSSvafSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564355916 684 NGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKVF 746
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGH----TGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 662-701 5.13e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 5.13e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564355916   662 TGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 701
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
663-701 9.27e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 9.27e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564355916  663 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 701
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 419-458 1.42e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.42e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564355916   419 TWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWN 458
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
420-458 6.83e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 6.83e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564355916  420 WNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWN 458
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 531-564 1.38e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.38e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 564355916   531 TLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWN 564
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
530-564 7.61e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 7.61e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 564355916  530 GTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWN 564
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
417-460 1.12e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 1.12e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 564355916 417 RKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQ 460
Cdd:COG2319  359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 474-511 1.22e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.22e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 564355916   474 EPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWN 511
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
474-511 1.04e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.04e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 564355916  474 EPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWN 511
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 704-746 7.34e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 7.34e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 564355916   704 SKTCVQEITAHRKkldeSIYDVAFHPSKAYIASAGADALAKVF 746
Cdd:smart00320   1 SGELLKTLKGHTG----PVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
705-746 5.08e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 5.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564355916  705 KTCVQEITAHRKkldeSIYDVAFHPSKAYIASAGADALAKVF 746
Cdd:pfam00400   1 GKLLKTLEGHTG----SVTSLAFSPDGKLLASGSDDGTVKVW 38
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 663-728 5.08e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.67  E-value: 5.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564355916  663 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNL--------DSKTCVQEItaHRKklDESIYDVAFH 728
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrssekRSRNTQTEF--PRK--DHVIAETPFH 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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