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Conserved domains on  [gi|564354237|ref|XP_006239521|]
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GDH/6PGL endoplasmic bifunctional protein isoform X1 [Rattus norvegicus]

Protein Classification

6-phosphogluconolactonase; sugar phosphate isomerase family( domain architecture ID 13232975)

6-phosphogluconolactonase catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate, which is the the second step of the oxidative phase of the pentose phosphate pathway| sugar phosphate isomerase family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00309 super family cl29403
glucose-6-phosphate 1-dehydrogenase; Provisional
 23-502 1.18e-94

glucose-6-phosphate 1-dehydrogenase; Provisional


The actual alignment was detected with superfamily member PTZ00309:

Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 305.91  E-value: 1.18e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  23 VSIILLGATGDLAKKYLWQGLFQLYLDeaGK-GHSFSFHGAALTAPQQGQKLMDKALeslscPKDLVPSRCDELKA-QFL 100
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYCE--GLlPSEVNIVGYARSKMSDVERWKKETL-----ARFFKRLDDRECHLeQFL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 101 QLSQYR--QLKTVEDYQTLNKDIETQVQQDGLWEAG--RVFYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEKPFGHD 176
Cdd:PTZ00309 128 KHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFGRD 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 177 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGV 256
Cdd:PTZ00309 207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGI 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 257 IRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKSNAILGQYQAYSGQ----VRQELQKPDGfqSLTP 332
Cdd:PTZ00309 286 IRDVMQNHLLQILALLAME-KPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGsipgYLEDEGVPKD--STTP 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 333 TFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNrayctqgerhwVPErsrclpqqIVFY---IGHGEL----- 404
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----------VDE--------FRPSgddTQRNELviraq 423

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 405 GHPAILVSKNLFKPSLPAQSWKGVQDQPGLHLFGrplsdyyayrpVREQDAYSTLLSHIFHCRKESFITTENLLASWVFW 484
Cdd:PTZ00309 424 PSEAMYLKITAKVPGLSNDLHQTELDLTYKTRYN-----------VRLPDAYERLILDALLGDSTNFVRKDELDVAWRIF 492

                        490       500
                 ....*....|....*....|
gi 564354237 485 TPLLDSL-SFEV-PRLYPGG 502
Cdd:PTZ00309 493 TPLLHQIdRGEVkPEPYPFG 512
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 554-789 1.97e-90

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


:

Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 283.88  E-value: 1.97e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  554 ITAWPEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGhySFPWAYTHLWLVDERCVPLSDPDSNFQG 633
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQ--PLDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  634 LQAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVAN---SSFDLVLLGMGTDGHTASLFPQSPRGLDG 710
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTEL-----SDIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  711 DQLV-VLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPlSGQLVWYMDYEAFLG 789
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLH-SGKTLWLLDYAAARK 232
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 23-502 1.18e-94

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 305.91  E-value: 1.18e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  23 VSIILLGATGDLAKKYLWQGLFQLYLDeaGK-GHSFSFHGAALTAPQQGQKLMDKALeslscPKDLVPSRCDELKA-QFL 100
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYCE--GLlPSEVNIVGYARSKMSDVERWKKETL-----ARFFKRLDDRECHLeQFL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 101 QLSQYR--QLKTVEDYQTLNKDIETQVQQDGLWEAG--RVFYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEKPFGHD 176
Cdd:PTZ00309 128 KHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFGRD 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 177 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGV 256
Cdd:PTZ00309 207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGI 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 257 IRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKSNAILGQYQAYSGQ----VRQELQKPDGfqSLTP 332
Cdd:PTZ00309 286 IRDVMQNHLLQILALLAME-KPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGsipgYLEDEGVPKD--STTP 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 333 TFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNrayctqgerhwVPErsrclpqqIVFY---IGHGEL----- 404
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----------VDE--------FRPSgddTQRNELviraq 423

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 405 GHPAILVSKNLFKPSLPAQSWKGVQDQPGLHLFGrplsdyyayrpVREQDAYSTLLSHIFHCRKESFITTENLLASWVFW 484
Cdd:PTZ00309 424 PSEAMYLKITAKVPGLSNDLHQTELDLTYKTRYN-----------VRLPDAYERLILDALLGDSTNFVRKDELDVAWRIF 492

                        490       500
                 ....*....|....*....|
gi 564354237 485 TPLLDSL-SFEV-PRLYPGG 502
Cdd:PTZ00309 493 TPLLHQIdRGEVkPEPYPFG 512
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 554-789 1.97e-90

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 283.88  E-value: 1.97e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  554 ITAWPEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGhySFPWAYTHLWLVDERCVPLSDPDSNFQG 633
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQ--PLDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  634 LQAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVAN---SSFDLVLLGMGTDGHTASLFPQSPRGLDG 710
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTEL-----SDIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  711 DQLV-VLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPlSGQLVWYMDYEAFLG 789
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLH-SGKTLWLLDYAAARK 232
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 25-502 3.80e-83

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 273.43  E-value: 3.80e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237   25 IILLGATGDLAKKYLWQGLFQLY----LDEagkghSFSFHGAALTAPQQGQ--KLMDKALESlSCPKDLvpsrcDELKAQ 98
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFrnglLPP-----DFRIVGVARRDWSVEEfrKVVREAIIK-FETDEI-----DEQWDE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237   99 FLQLSQYR--QLKTVEDYQTLNKDIEtQVQQDGLWEAGRVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHD 176
Cdd:TIGR00871  74 FAQRLSYVsgDVDDDESYDSLAELLE-QLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHD 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  177 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGV 256
Cdd:TIGR00871 153 LASAQELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQ-IFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  257 IRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQK--SNAILGQYQAysGQVRQElQKP-----DGF-- 327
Cdd:TIGR00871 232 LRDMVQNHLLQLLALVAME-PPVSFDADSIRDEKVKVLKALRPIDPddNNTVRGQYGA--GEIGGV-SVPgyleeEGVdk 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  328 QSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNrayctqgerhwVP-------ERSRCLPQQIVFYIG 400
Cdd:TIGR00871 308 DSNTETFAALKLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRD-----------VPsllfkanERDANPRNALVIRIQ 376

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  401 HGElghpAILVSKNLFKPSLPAQswkgVQDqpgLHLFGRPLSDYYAYRPvreqDAYSTLLSHIFHCRKESFITTENLLAS 480
Cdd:TIGR00871 377 PDE----GVYLKFNAKKPGLNFE----TRP---VKLDFSYASRFGELLP----EAYERLLLDALLGDHTLFARDDEVEEA 441

                         490       500
                  ....*....|....*....|....*
gi 564354237  481 WVFWTPLLDSL---SFEVPRLYPGG 502
Cdd:TIGR00871 442 WRIVTPILEAWaanKGPSPPNYPAG 466
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
556-780 5.26e-83

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 263.71  E-value: 5.26e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  556 AWPEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGHYSFPWAYTHLWLVDERCVPLSDPDSNFQGLQ 635
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  636 AHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVANSS---FDLVLLGMGTDGHTASLFPQSPRGLDGDQ 712
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPASA-----ADPEEAAAAYEAELRELLPDLElpvFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  713 LVV-LTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV-GHEPKKWPISGVVPLSGQLVW 780
Cdd:pfam01182 156 LVVaVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADA---LRRAlAGDPDPLPAALVRPGAGETVW 222
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 559-782 2.16e-78

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 251.71  E-value: 2.16e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 559 EELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGhYSFPWAYTHLWLVDERCVPLSDPDSNFQGLQAHL 638
Cdd:cd01400    1 EALAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDWSKVHVFLGDERCVPPDDPDSNYRLAREAL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 639 LQHVRVPYYNIHPMPVHLHqrlcaeEDQGAQTYASEISALVANS-SFDLVLLGMGTDGHTASLFPQSPR-GLDGDQLVVL 716
Cdd:cd01400   80 LSHVAIPAANIHPIPTELG------PEDAAAAYEKELRALFGGVpPFDLVLLGMGPDGHTASLFPGHPAlLEETDRLVVA 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564354237 717 TE-SPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSGQLVWYM 782
Cdd:cd01400  154 VTdSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEA---LKRAlaGPDPEELPAARVLPRPGEVLWFL 219
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 25-372 2.17e-78

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 261.16  E-value: 2.17e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  25 IILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTaPQQGQKLMDKALESLscpKDLVPSRCDELK-AQFL 100
Cdd:COG0364   12 LVIFGATGDLARRKLLPALYNLYRD----GLlpeGFRIIGVARR-DWSDEEFREEVREAL---EEFSRKPFDEEVwERFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 101 QLSQYRQL--KTVEDYQTLNKDIEtqvQQDGLWEAG-RVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDH 177
Cdd:COG0364   84 ERLHYVSGdfTDPEGYERLKELLE---ELDEERTPGnRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 178 LSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGVI 257
Cdd:COG0364  161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANA-LFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 258 RDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKS----NAILGQYQAysGQV--------RQElqkpD 325
Cdd:COG0364  240 RDMVQNHLLQLLCLVAME-PPASLDADAIRDEKVKVLRALRPITPEdvaeNTVRGQYTA--GWIggepvpgyREE----P 312

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 564354237 326 GF--QSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKN 372
Cdd:COG0364  313 GVapDSTTETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKP 361
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
225-510 1.14e-64

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 217.69  E-value: 1.14e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  225 LWNRHHVERVEIILKETVDAGGRASFYEEYGVIRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKS- 303
Cdd:pfam02781  13 LWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAME-PPVSFDAEDIRDEKVKVLRSLRPITPEd 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  304 ---NAILGQYQA--YSGQV----RQELQKPDGfqSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNra 374
Cdd:pfam02781  92 vedNVVRGQYGAgwIGGEPvpgyREEEGVPPD--SRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEIRIQFKD-- 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  375 yctqgerhwVP-----ERSRCLPQQIVFYIGHGElghpAILVSKNLFKpslpaqswkgvqdqPGLHLFGRPLS---DYYA 446
Cdd:pfam02781 168 ---------VPhnlfrDPGTLPPNELVIRIQPDE----GIYLKFNAKV--------------PGLGMRLRPVEldfSYSD 220

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564354237  447 YRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDSLSFEVPRLYPGG----AENDHLLD 510
Cdd:pfam02781 221 RFGERIPEAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAGswgpKAADELLA 288
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 558-786 4.69e-55

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 189.99  E-value: 4.69e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 558 PEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGHYS--FPWAYTHLWLVDERC-VPLSDPDSNFQGL 634
Cdd:COG0363   10 AEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKEggLDWSRVHVFNLDEYVgLPPDHPQSNRRFM 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 635 QAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTASLFPQSPRGLDGDQLV 714
Cdd:COG0363   90 REALLDHVDIPPENIHIPDGEA-----EDPEAAAARYEALIAEA---GGIDLQLLGIGEDGHIAFNFPGSPFLSETDRVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 715 VLTESPFR------------PHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSgQLVW 780
Cdd:COG0363  162 TLDESTRQanarffgsipkvPPQAITLGIPTIMKAREILLLATGENKAEA---VAAAleGPVTEEVPASILQGHP-NVTW 237


                 ....*.
gi 564354237 781 YMDYEA 786
Cdd:COG0363  238 FLDEAA 243
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 559-786 3.13e-30

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 120.35  E-value: 3.13e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 559 EELISKLANDIEAAAVQAVRRFGKFHLALSGGSSpIALFQQLATGHY--SFPWAYTHLWLVDERCVPLSDPDSNFQGLQA 636
Cdd:PLN02360  20 DELSTDLAEYIAELSEASVKERGVFAIALSGGSL-ISFMGKLCEAPYnkTVDWAKWYIFWADERVVAKNHADSNYKLAKD 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 637 HLLQHVRVPYYNIHPmpvhLHQRLCAEEdqGAQTYASEISALVANSS-----------FDLVLLGMGTDGHTASLFPQSP 705
Cdd:PLN02360  99 GLLSKVPVVPSHVYS----INDTVTAEE--AATDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNHP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 706 R-GLDGDQLVVLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTL-VSRVGHEP--KKWPISGVVPLSGQLVWY 781
Cdd:PLN02360 173 AlEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLaIDDVTEGPdaPSLPARMVQPTKGKLVWF 252


                 ....*
gi 564354237 782 MDYEA 786
Cdd:PLN02360 253 LDKPA 257
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 23-502 1.18e-94

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 305.91  E-value: 1.18e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  23 VSIILLGATGDLAKKYLWQGLFQLYLDeaGK-GHSFSFHGAALTAPQQGQKLMDKALeslscPKDLVPSRCDELKA-QFL 100
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYCE--GLlPSEVNIVGYARSKMSDVERWKKETL-----ARFFKRLDDRECHLeQFL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 101 QLSQYR--QLKTVEDYQTLNKDIETQVQQDGLWEAG--RVFYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEKPFGHD 176
Cdd:PTZ00309 128 KHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFGRD 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 177 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGV 256
Cdd:PTZ00309 207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGI 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 257 IRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKSNAILGQYQAYSGQ----VRQELQKPDGfqSLTP 332
Cdd:PTZ00309 286 IRDVMQNHLLQILALLAME-KPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGsipgYLEDEGVPKD--STTP 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 333 TFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNrayctqgerhwVPErsrclpqqIVFY---IGHGEL----- 404
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----------VDE--------FRPSgddTQRNELviraq 423

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 405 GHPAILVSKNLFKPSLPAQSWKGVQDQPGLHLFGrplsdyyayrpVREQDAYSTLLSHIFHCRKESFITTENLLASWVFW 484
Cdd:PTZ00309 424 PSEAMYLKITAKVPGLSNDLHQTELDLTYKTRYN-----------VRLPDAYERLILDALLGDSTNFVRKDELDVAWRIF 492

                        490       500
                 ....*....|....*....|
gi 564354237 485 TPLLDSL-SFEV-PRLYPGG 502
Cdd:PTZ00309 493 TPLLHQIdRGEVkPEPYPFG 512
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 554-789 1.97e-90

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 283.88  E-value: 1.97e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  554 ITAWPEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGhySFPWAYTHLWLVDERCVPLSDPDSNFQG 633
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQ--PLDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  634 LQAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVAN---SSFDLVLLGMGTDGHTASLFPQSPRGLDG 710
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTEL-----SDIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  711 DQLV-VLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPlSGQLVWYMDYEAFLG 789
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLH-SGKTLWLLDYAAARK 232
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 25-502 3.80e-83

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 273.43  E-value: 3.80e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237   25 IILLGATGDLAKKYLWQGLFQLY----LDEagkghSFSFHGAALTAPQQGQ--KLMDKALESlSCPKDLvpsrcDELKAQ 98
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFrnglLPP-----DFRIVGVARRDWSVEEfrKVVREAIIK-FETDEI-----DEQWDE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237   99 FLQLSQYR--QLKTVEDYQTLNKDIEtQVQQDGLWEAGRVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHD 176
Cdd:TIGR00871  74 FAQRLSYVsgDVDDDESYDSLAELLE-QLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHD 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  177 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGV 256
Cdd:TIGR00871 153 LASAQELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQ-IFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  257 IRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQK--SNAILGQYQAysGQVRQElQKP-----DGF-- 327
Cdd:TIGR00871 232 LRDMVQNHLLQLLALVAME-PPVSFDADSIRDEKVKVLKALRPIDPddNNTVRGQYGA--GEIGGV-SVPgyleeEGVdk 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  328 QSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNrayctqgerhwVP-------ERSRCLPQQIVFYIG 400
Cdd:TIGR00871 308 DSNTETFAALKLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRD-----------VPsllfkanERDANPRNALVIRIQ 376

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  401 HGElghpAILVSKNLFKPSLPAQswkgVQDqpgLHLFGRPLSDYYAYRPvreqDAYSTLLSHIFHCRKESFITTENLLAS 480
Cdd:TIGR00871 377 PDE----GVYLKFNAKKPGLNFE----TRP---VKLDFSYASRFGELLP----EAYERLLLDALLGDHTLFARDDEVEEA 441

                         490       500
                  ....*....|....*....|....*
gi 564354237  481 WVFWTPLLDSL---SFEVPRLYPGG 502
Cdd:TIGR00871 442 WRIVTPILEAWaanKGPSPPNYPAG 466
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 25-372 4.34e-83

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 273.54  E-value: 4.34e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  25 IILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTA--PQQGQKLMDKALESLSCPKdlvpsRCDELKAQF 99
Cdd:PRK05722  12 LVIFGATGDLARRKLLPALYNLYKA----GLlpeDFRIIGVARRDwsDEDFREVVREALKEFARTP-----FDEEVWERF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 100 LQLSQYRQ--LKTVEDYQTLNKDIETQVQQDGLwEAGRVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDH 177
Cdd:PRK05722  83 LSRLYYVSgdVTDPESYERLKELLEELDEERGT-GGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 178 LSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNrkAL-DGLWNRHHVERVEIILKETVDAGGRASFYEEYGV 256
Cdd:PRK05722 162 ASARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFAN--ALfEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 257 IRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQ----KSNAILGQYQAysGQV--------RQELQKP 324
Cdd:PRK05722 240 LRDMVQNHLLQLLALVAME-PPASLDADSIRDEKVKVLRALRPITpedvKENTVRGQYTA--GWIggkpvpgyREEEGVN 316

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 564354237 325 DgfQSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKN 372
Cdd:PRK05722 317 P--DSTTETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKP 362
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
556-780 5.26e-83

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 263.71  E-value: 5.26e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  556 AWPEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGHYSFPWAYTHLWLVDERCVPLSDPDSNFQGLQ 635
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  636 AHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVANSS---FDLVLLGMGTDGHTASLFPQSPRGLDGDQ 712
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPASA-----ADPEEAAAAYEAELRELLPDLElpvFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  713 LVV-LTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV-GHEPKKWPISGVVPLSGQLVW 780
Cdd:pfam01182 156 LVVaVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADA---LRRAlAGDPDPLPAALVRPGAGETVW 222
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 21-488 3.20e-81

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 268.52  E-value: 3.20e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  21 GHVSIILLGATGDLAKKYLWQGLFQLYLDEAGKGHSFSFHGAALTaPQQGQKLMDKALESLSCPKDlvpsRCDELKAQFL 100
Cdd:PLN02539  16 GCLSIIVLGASGDLAKKKTFPALFNLYRQGFLPPDEVHIFGYARS-KITDEELRDRIRGYLKDEKN----APAEAVSKFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 101 QLSQYRQ--LKTVEDYQTLNKDI-ETQVQQDGLWEAG-RVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHD 176
Cdd:PLN02539  91 QLIKYVSgaYDSEEGFRRLDKEIsEHEISKNSAEGSSrRLFYLALPPSVYPPVCKMIKKCCMNKSGLWTRIVVEKPFGKD 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 177 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDgLWNRHHVERVEIILKETVDAGGRASFYEEYGV 256
Cdd:PLN02539 171 LESAEELSSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLP-LWNRDNIANVQIVFREDFGTEGRGGYFDEYGI 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 257 IRDTLQNHLTEILTLVAMELPPNISSSaAVLQHKLQAFQALRGLQKSNAILGQYQAYsgqvRQELQKPDGfqSLTPTFAG 336
Cdd:PLN02539 250 IRDIIQNHLLQVLCLVAMEKPVSLKPE-HIRDEKVKVLQSVEPIKDEEVVLGQYEGY----RDDPTVPDD--SNTPTFAS 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 337 VLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNrayctqgerhwVP-ERSRCLPQqivfyighgelghpailvSKNL 415
Cdd:PLN02539 323 VVLRINNERWEGVPFILKAGKALDSRKAEIRVQFKD-----------VPgDIFKCQKQ------------------GRNE 373

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 416 F----KPSlPAQSWKGVQDQPGLHLFGRP----LSDYYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPL 487
Cdd:PLN02539 374 FvirlQPS-EAMYMKLTVKQPGLEMSTVQseldLSYGQRYQDVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPL 452


                 .
gi 564354237 488 L 488
Cdd:PLN02539 453 L 453
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 559-782 2.16e-78

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 251.71  E-value: 2.16e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 559 EELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGhYSFPWAYTHLWLVDERCVPLSDPDSNFQGLQAHL 638
Cdd:cd01400    1 EALAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDWSKVHVFLGDERCVPPDDPDSNYRLAREAL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 639 LQHVRVPYYNIHPMPVHLHqrlcaeEDQGAQTYASEISALVANS-SFDLVLLGMGTDGHTASLFPQSPR-GLDGDQLVVL 716
Cdd:cd01400   80 LSHVAIPAANIHPIPTELG------PEDAAAAYEKELRALFGGVpPFDLVLLGMGPDGHTASLFPGHPAlLEETDRLVVA 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564354237 717 TE-SPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSGQLVWYM 782
Cdd:cd01400  154 VTdSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEA---LKRAlaGPDPEELPAARVLPRPGEVLWFL 219
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 25-372 2.17e-78

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 261.16  E-value: 2.17e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  25 IILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTaPQQGQKLMDKALESLscpKDLVPSRCDELK-AQFL 100
Cdd:COG0364   12 LVIFGATGDLARRKLLPALYNLYRD----GLlpeGFRIIGVARR-DWSDEEFREEVREAL---EEFSRKPFDEEVwERFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 101 QLSQYRQL--KTVEDYQTLNKDIEtqvQQDGLWEAG-RVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDH 177
Cdd:COG0364   84 ERLHYVSGdfTDPEGYERLKELLE---ELDEERTPGnRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 178 LSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGVI 257
Cdd:COG0364  161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANA-LFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 258 RDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKS----NAILGQYQAysGQV--------RQElqkpD 325
Cdd:COG0364  240 RDMVQNHLLQLLCLVAME-PPASLDADAIRDEKVKVLRALRPITPEdvaeNTVRGQYTA--GWIggepvpgyREE----P 312

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 564354237 326 GF--QSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKN 372
Cdd:COG0364  313 GVapDSTTETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKP 361
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
25-509 2.54e-71

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 241.73  E-value: 2.54e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  25 IILLGATGDLAKKYLWQGLFQLYLDEAgKGHSFSFHGAALTAPQQGQ--KLMDKALESLScPKDLVPSRCDelkaQFLQL 102
Cdd:PRK12853  11 LVIFGATGDLARRKLLPALYRLARAGL-LPEDLRIIGVGRDDWSDEQwrARVRESLRAFG-ADGFDDAVWD----RLAAR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 103 SQYRQ--LKTVEDYQTLNKDIETQVQqdglweagRVFYFSVPPFAYADIARNINSS-CRPhpgAWLRVVFEKPFGHDHLS 179
Cdd:PRK12853  85 LSYVQgdVTDPADYARLAEALGPGGN--------PVFYLAVPPSLFAPVVENLGAAgLLP---EGRRVVLEKPFGHDLAS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 180 AQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGVIRD 259
Cdd:PRK12853 154 ARALNATLAKVFDEDQIYRIDHFLGKETVQNLLALRFANA-LLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 260 TLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKSNAIL--GQYQAysGQV--------RQELQKPDGfqS 329
Cdd:PRK12853 233 MVQNHLLQLLALVAME-PPASFDADAVRDEKAKVLRAIRPLDPDDVHTvrGQYTA--GTVggepvpgyREEPGVDPD--S 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 330 LTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNRAYCTQGERHwvpersRCLPQQIVFYIGHGELGHPAI 409
Cdd:PRK12853 308 RTETFVALKLEIDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPHALFRGTG------VEPPNRLVIRLQPDEGISLEL 381

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 410 LVSknlfkpslpaqswkgvqdQPGLHLFGRPLSDYYAYR-PVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLL 488
Cdd:PRK12853 382 NVK------------------RPGPGMRLRPVELDADYAdDERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVL 443

                        490       500
                 ....*....|....*....|....*..
gi 564354237 489 D--SLSFEVPRLYPGG----AENDHLL 509
Cdd:PRK12853 444 DawAADPVPPHEYPAGswgpAAADALL 470
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 15-503 3.43e-70

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 241.46  E-value: 3.43e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  15 QAQEFRGHVSIILLGATGDLAKKYLWQGLFQLYLdEAGKGHSFSFHGAALTAPQQgQKLMDKALESLSCPKDlVPSRCDE 94
Cdd:PLN02640  81 HAEKGESTLSITVVGASGDLAKKKIFPALFALFY-EDWLPENFTVFGYARTKLTD-EELRDMISSTLTCRID-QRENCGD 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  95 LKAQFLQLSQYR--QLKTVEDYQTLNKDIETQvqqdglwEAG----RVFYFSVPPFAYADIARNINSSCRPHPGaWLRVV 168
Cdd:PLN02640 158 KMDQFLKRCFYHsgQYDSEEDFAELNKKLKEK-------EAGklsnRLFYLSIPPNIFVDVVRCASLRASSENG-WTRVI 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 169 FEKPFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRA 248
Cdd:PLN02640 230 VEKPFGRDSESSGELTRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNL-VFEPLWSRNYIRNVQLIFSEDFGTEGRG 308

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 249 SFYEEYGVIRDTLQNHLTEILTLVAMELPPNISSSaAVLQHKLQAFQALRGLQKSNAILGQYQAYSGQVR------QELQ 322
Cdd:PLN02640 309 GYFDNYGIIRDIMQNHLLQILALFAMETPVSLDAE-DIRNEKVKVLRSMKPLQLEDVIVGQYKGHSKGGKsypaytDDPT 387

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 323 KPDGfqSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKN-------RAYCTQGERhwvpersrcLPQQI 395
Cdd:PLN02640 388 VPKH--SLTPTFAAAALFINNARWDGVPFLMKAGKALHTRRAEIRVQFRHvpgnlykRNFGTDLDK---------ATNEL 456

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 396 VFYIGHGElghpAILVSKNLFKPSLpaqswkgvqdqpGLHLFGRPLSDYYAYRPVRE-QDAYSTLLSHIFHCRKESFITT 474
Cdd:PLN02640 457 VLRVQPDE----AIYLKINNKVPGL------------GMRLDRSDLNLLYRARYPREiPDAYERLLLDAIEGERRLFIRS 520

                        490       500       510
                 ....*....|....*....|....*....|.
gi 564354237 475 ENLLASWVFWTPLLDSLSFE--VPRLYPGGA 503
Cdd:PLN02640 521 DELDAAWALFTPLLKELEEKkiIPELYPYGS 551
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 23-503 1.33e-69

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 240.65  E-value: 1.33e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  23 VSIILLGATGDLAKKYLWQGLFQLYLDEAGKGHsFSFHGAALTapqqgqKLMDKAL-----ESLSCPKDlVPSRCDELKA 97
Cdd:PLN02333 118 VSITVVGASGDLAKKKIFPALFALYYEGCLPEH-FTIFGYARS------KMTDAELrnmvsKTLTCRID-KRENCGEKME 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  98 QFLQLSQYR--QLKTVEDYQTLNKDIETQvqqdglwEAGRV----FYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEK 171
Cdd:PLN02333 190 EFLKRCFYHsgQYDSQEHFAELDKKLKEH-------EGGRVsnrlFYLSIPPNIFVDAVKCASSSASSVNG-WTRVIVEK 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 172 PFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFY 251
Cdd:PLN02333 262 PFGRDSESSAALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNL-IFEPLWSRQYIRNVQFIFSEDFGTEGRGGYF 340

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 252 EEYGVIRDTLQNHLTEILTLVAMELPPNISSSaAVLQHKLQAFQALRGLQKSNAILGQYQAYS-GQVR-----QELQKPD 325
Cdd:PLN02333 341 DNYGIIRDIMQNHLLQILALFAMETPVSLDAE-DIRNEKVKVLRSMRPIQLEDVVIGQYKSHTkGGVTypaytDDKTVPK 419

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 326 GfqSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFK-------NRAYCTQGERhwvpersrcLPQQIVFY 398
Cdd:PLN02333 420 G--SLTPTFAAAALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRhvpgnlyNRNFGTDLDQ---------ATNELVIR 488

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 399 IGHGElghpAILVSKNLFKPSLpaqswkGVQ-DQPGLHLfgrplsdYYAYRPVRE-QDAYSTLLSHIFHCRKESFITTEN 476
Cdd:PLN02333 489 VQPDE----AIYLKINNKVPGL------GMRlDRSNLNL-------LYAARYSKEiPDAYERLLLDAIEGERRLFIRSDE 551

                        490       500
                 ....*....|....*....|....*....
gi 564354237 477 LLASWVFWTPLLDSLSFE--VPRLYPGGA 503
Cdd:PLN02333 552 LDAAWALFTPLLKELEEKkiIPEYYPYGS 580
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
225-510 1.14e-64

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 217.69  E-value: 1.14e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  225 LWNRHHVERVEIILKETVDAGGRASFYEEYGVIRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKS- 303
Cdd:pfam02781  13 LWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAME-PPVSFDAEDIRDEKVKVLRSLRPITPEd 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  304 ---NAILGQYQA--YSGQV----RQELQKPDGfqSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNra 374
Cdd:pfam02781  92 vedNVVRGQYGAgwIGGEPvpgyREEEGVPPD--SRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEIRIQFKD-- 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  375 yctqgerhwVP-----ERSRCLPQQIVFYIGHGElghpAILVSKNLFKpslpaqswkgvqdqPGLHLFGRPLS---DYYA 446
Cdd:pfam02781 168 ---------VPhnlfrDPGTLPPNELVIRIQPDE----GIYLKFNAKV--------------PGLGMRLRPVEldfSYSD 220

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564354237  447 YRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDSLSFEVPRLYPGG----AENDHLLD 510
Cdd:pfam02781 221 RFGERIPEAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAGswgpKAADELLA 288
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 25-502 4.35e-64

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 222.22  E-value: 4.35e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  25 IILLGATGDLAKKYLWQGLFQLYLDE--------AGKGHSfsfhgaALTAPQQGQKLMDKALESLSCPKDlvpsrcDELK 96
Cdd:PRK12854  14 FVLFGATGDLAKRKLLPGLFHLARAGllppdwriVGTGRG------DVSAEAFREHARDALDEFGARKLD------DGEW 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  97 AQFLQLSQYRQLK-TVEDYQTLnKDIETQVQQDGLWEAGRVFYFSVPPFAYADIARNInsscrphPGAWL----RVVFEK 171
Cdd:PRK12854  82 ARFAKRLRYVPGGfLSAGPGAL-AAAVAAARAELGGDARLVHYLAVPPSAFLDVTRAL-------GEAGLaegsRVVMEK 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 172 PFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFY 251
Cdd:PRK12854 154 PFGTDLASAEALNAAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANG-LFEPIWNREFIDHVQIDVPETLGVDTRAAFY 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 252 EEYGVIRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKSNAILGQYQAYsgqvRQELQKPDgfQSLT 331
Cdd:PRK12854 233 DATGAYRDMVVTHLFQVLAFVAME-PPTALEPDAISEEKNKVFRSMRPLDPAEVVRGQYSGY----RDEPGVAP--DSTT 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 332 PTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNrayctqgerhwvPERSrclpqqiVFYIGHGELGHPAILv 411
Cdd:PRK12854 306 ETFVALKVWIDNWRWAGVPFYLRTGKRMAEGQRIISIAFRE------------PPYS-------MFPAGSVGAQGPDHL- 365

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 412 SKNLFKPSLPAQSWKGVQDQPGLHLfgRPLSDYYAYRPVREQ----DAYSTLLSHIFHCRKESFITTENLLASWVFWTPL 487
Cdd:PRK12854 366 TFDLADNSKVSLSFYGKRPGPGMRL--DKLSLQFSLKDTGPKgdvlEAYERLILDALRGDHTLFTTADGIESLWEVSQPL 443

                        490
                 ....*....|....*
gi 564354237 488 LDSLSfeVPRLYPGG 502
Cdd:PRK12854 444 LEDPP--PVKPYAPG 456
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 558-786 4.69e-55

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 189.99  E-value: 4.69e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 558 PEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGHYS--FPWAYTHLWLVDERC-VPLSDPDSNFQGL 634
Cdd:COG0363   10 AEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKEggLDWSRVHVFNLDEYVgLPPDHPQSNRRFM 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 635 QAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTASLFPQSPRGLDGDQLV 714
Cdd:COG0363   90 REALLDHVDIPPENIHIPDGEA-----EDPEAAAARYEALIAEA---GGIDLQLLGIGEDGHIAFNFPGSPFLSETDRVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 715 VLTESPFR------------PHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSgQLVW 780
Cdd:COG0363  162 TLDESTRQanarffgsipkvPPQAITLGIPTIMKAREILLLATGENKAEA---VAAAleGPVTEEVPASILQGHP-NVTW 237


                 ....*.
gi 564354237 781 YMDYEA 786
Cdd:COG0363  238 FLDEAA 243
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
26-208 3.43e-41

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 148.73  E-value: 3.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237   26 ILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTaPQQGQKLMDKALESLSCPKDlvpsRCDELKAQFLQL 102
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRD----GLlpeGFRIIGVARR-DLSDEEFRERVREALKEFKE----LDEEKWDRFLER 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237  103 SQYRQ--LKTVEDYQTLNKDIEtqvQQDGLWEAGRVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDHLSA 180
Cdd:pfam00479  72 LHYVSgdFDDPESYEKLKERLE---EHEDETRGNRLFYLAVPPSLFGPIAENLGRAGLSEEGGWRRVVIEKPFGHDLESA 148

                         170       180
                  ....*....|....*....|....*...
gi 564354237  181 QQLASELGSFFQEEEMYRVDHYLGKQAV 208
Cdd:pfam00479 149 RELNDQLAKVFKEEQIYRIDHYLGKETV 176
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 559-786 3.13e-30

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 120.35  E-value: 3.13e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 559 EELISKLANDIEAAAVQAVRRFGKFHLALSGGSSpIALFQQLATGHY--SFPWAYTHLWLVDERCVPLSDPDSNFQGLQA 636
Cdd:PLN02360  20 DELSTDLAEYIAELSEASVKERGVFAIALSGGSL-ISFMGKLCEAPYnkTVDWAKWYIFWADERVVAKNHADSNYKLAKD 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 637 HLLQHVRVPYYNIHPmpvhLHQRLCAEEdqGAQTYASEISALVANSS-----------FDLVLLGMGTDGHTASLFPQSP 705
Cdd:PLN02360  99 GLLSKVPVVPSHVYS----INDTVTAEE--AATDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNHP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 706 R-GLDGDQLVVLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTL-VSRVGHEP--KKWPISGVVPLSGQLVWY 781
Cdd:PLN02360 173 AlEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLaIDDVTEGPdaPSLPARMVQPTKGKLVWF 252


                 ....*
gi 564354237 782 MDYEA 786
Cdd:PLN02360 253 LDKPA 257
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 570-769 2.00e-13

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 70.59  E-value: 2.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 570 EAAA---VQAVRRFGKFHLALSGGSSPIALFQQLATGHYS--FPWAYTHLWLVDERcVPLS--DPDSNFQGLQAHLLQHV 642
Cdd:cd01399    5 EAAAeliAELIREKPPAVLGLATGSTPLGVYEELIELHKEggLSFSNVTTFNLDEY-VGLPpdHPQSYHYFMRENLFDHI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 643 RVPYYNIHPMPVhlhqrLCAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTAslFPQSPRGLDGD-QLVVLTES-- 719
Cdd:cd01399   84 DIKPENIHIPDG-----NAADLEAECRRYEALIAEA---GGIDLQLLGIGENGHIG--FNEPGSSLDSRtRVVTLDEStr 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564354237 720 -----PFR-----PHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRVGHEP--KKWPIS 769
Cdd:cd01399  154 qanarFFDgdedvPTQAITMGIGTIMKAKEILLLATGEGKAEA---VKKALEGPvtEECPAS 212
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 582-697 6.32e-08

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 53.13  E-value: 6.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 582 KFHLALSGGSSPIALFQQLATGHYSFPWAYTHLWLVDERCVPLSDPDSNFQGLQAHLLQHVRVPYYNIHPMPVHLhqrlc 661
Cdd:cd00458   21 DMVIGLGTGSTPAYFYKLLGEKLKRGEISDIVGFPTDERYVPLDSDQSNFRQAKLLAFEHDIIPASNVHYVDTSL----- 95

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 564354237 662 AEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHT 697
Cdd:cd00458   96 PIEKACEKYEREILDQV---DAIDLAVDGAGYRAGT 128
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 583-769 2.80e-07

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 52.45  E-value: 2.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 583 FHLALSGGSSPIALFQQLATGH----YSFPWAYThlWLVDERC-VPLSDPDSNFQGLQAHLLQHVrvpyyNIHPMPVHLH 657
Cdd:PTZ00285  35 FVLGLPTGSTPLPTYQELIRAYregrVSFSNVVT--FNMDEYVgLPRDHPQSYHYFMKENFFDHV-----DIKEENRHIL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 658 QRLCAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTASLFPQSPRGlDGDQLVVLTESPFR-------------PH 724
Cdd:PTZ00285 108 NGTAPDLEEECRRYEEKIRAV---GGIDLFLAGIGTDGHIAFNEPGSSLD-SRTRVKSLNQETIDanarffgndiskvPT 183

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 564354237 725 QRMSLSLPLINRAKKVAVLVMGRTKREITT--LVSRVGHepkKWPIS 769
Cdd:PTZ00285 184 MALTVGIRTIMEAREVLLLATGASKAIAVArcVEGGVTH---MCPAS 227
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 558-752 8.34e-06

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 49.26  E-value: 8.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 558 PEELISKLANDIeAAAVQAVRRFGKFH-LALSGGSSPIALFQQLATGH----YSFPWAYThlWLVDERcVPLS--DPDSN 630
Cdd:PRK02122  36 SEEASRAVAQEI-ATLIRERQAEGKPCvLGLATGSSPIGVYAELIRMHreegLSFKNVIT--FNLDEY-YPMQpdSLQSY 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 631 FQGLQAHLLQHVRVPYYNIHPMPVHLHQrlcAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTASLFPQSPRGlDG 710
Cdd:PRK02122 112 HRFMKENLFDHVDIPPENIHIPDGTIPK---EEIDEYCRDYEEKIEAA---GGIDFQLLGIGRTGHIGFNEPGSGRN-SR 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564354237 711 DQLVVLTESPFR------------PHQRMSLSLPLINRAKKVAVLVMGRTKREI 752
Cdd:PRK02122 185 TRLVTLDHITRRdaasdffgeenvPRKAITMGVGTILKARRIVLLAWGEHKAPI 238
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 566-769 2.63e-05

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 46.75  E-value: 2.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 566 ANDIEAAAVQAVRRFGK-FHLALSGGSSPIALFQQLATGHYS--FPWAYTHLWLVDE-RCVPLSDPDS--NFqgLQAHLL 639
Cdd:PRK00443  17 ARHIANRINAFLPTKERpFVLGLATGSSPLETYKALIELHKAgkVDFSRVTTFNLDEyVGLPADHPESyrYF--MRENFF 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 640 QHVrvpyyNIHPMPVHLHQRLCAEEDQGAQTYASEIsalVANSSFDLVLLGMGTDGHTAslF--PQSPrgLDGDQLVV-L 716
Cdd:PRK00443  95 DHV-----DIPPENINLLNGNAPDPEAECRRYEEKI---KSAGGIDLQILGIGENGHIA--FnePGSS--FASRTRIKtL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564354237 717 TESPFR-------------PHQRMSLSLPLINRAKKVAVLVMGRTKREIT--TLVSRVGHEpkkWPIS 769
Cdd:PRK00443 163 TEDTRIansrffdgdieqvPKYALTVGVGTILDAKEIMLLAPGHNKAEAVkaAVEGPVNHM---WPAS 227
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
582-696 2.68e-03

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 40.12  E-value: 2.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354237 582 KFHLALSGGSSPIALFQQLATGHYSFPW-AYTHLWLVDErcVPLSDPDS---NFQGLQAHLLQHVRVPYYNIHPMPVhlh 657
Cdd:PRK12358  29 RVNLAITAGSTPKGMYEYLITLVKGKAWyDNVHYYNFDE--IPFRGKEGegvTITNLRNLFFTPAGIKEENIHKLTI--- 103

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 564354237 658 qrlcaeedqgaQTYASEISALVANSSFDLVLLGMGTDGH 696
Cdd:PRK12358 104 -----------DNYREHDQKLARDGGLDLVVLGLGADGH 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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