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Conserved domains on  [gi|564350803|ref|XP_006238128|]
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DDB1- and CUL4-associated factor 10 isoform X1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
49-496 2.27e-04

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 2.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803  49 ASPPPATGSPRLRGSPAVSPAERAGELAAPEALELSAAASQAELSPSSSPRRRSRPDCKAGSWSRQGLSAGLGGPGARLF 128
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803 129 GWLRERSLGRGLFVDPARDNFRTMTNLYGSIHPAdsvyLSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIK 208
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLR----TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803 209 TLSeAHEDCVNNIRCTEDGcphkkffhtrflmrmrltpdcsKMLISTSSGYLLILHDLD---LTKSLEVGSYPILRArrt 285
Cdd:COG2319  157 TLT-GHSGAVTSVAFSPDG----------------------KLLASGSDDGTVRLWDLAtgkLLRTLTGHTGAVRSV--- 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803 286 tsssdlttsssssgsrvsgspCHHNDSnsteKHVSRASQREGV---SPRNSLEVLTPevpgeRDRGNCITSLQLHPKGwA 362
Cdd:COG2319  211 ---------------------AFSPDG----KLLASGSADGTVrlwDLATGKLLRTL-----TGHSGSVRSVAFSPDG-R 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803 363 TLLrcsSNTDDQEwTCVYEFQEGAPVRpvsprcslRLTHyieeanvGRGYIKELCFSPDGRMI-SSPHGYGIRLLgfdkq 441
Cdd:COG2319  260 LLA---SGSADGT-VRLWDLATGELLR--------TLTG-------HSGGVNSVAFSPDGKLLaSGSDDGTVRLW----- 315

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564350803 442 cselvdclpkEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPK 496
Cdd:COG2319  316 ----------DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
49-496 2.27e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 2.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803  49 ASPPPATGSPRLRGSPAVSPAERAGELAAPEALELSAAASQAELSPSSSPRRRSRPDCKAGSWSRQGLSAGLGGPGARLF 128
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803 129 GWLRERSLGRGLFVDPARDNFRTMTNLYGSIHPAdsvyLSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIK 208
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLR----TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803 209 TLSeAHEDCVNNIRCTEDGcphkkffhtrflmrmrltpdcsKMLISTSSGYLLILHDLD---LTKSLEVGSYPILRArrt 285
Cdd:COG2319  157 TLT-GHSGAVTSVAFSPDG----------------------KLLASGSDDGTVRLWDLAtgkLLRTLTGHTGAVRSV--- 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803 286 tsssdlttsssssgsrvsgspCHHNDSnsteKHVSRASQREGV---SPRNSLEVLTPevpgeRDRGNCITSLQLHPKGwA 362
Cdd:COG2319  211 ---------------------AFSPDG----KLLASGSADGTVrlwDLATGKLLRTL-----TGHSGSVRSVAFSPDG-R 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803 363 TLLrcsSNTDDQEwTCVYEFQEGAPVRpvsprcslRLTHyieeanvGRGYIKELCFSPDGRMI-SSPHGYGIRLLgfdkq 441
Cdd:COG2319  260 LLA---SGSADGT-VRLWDLATGELLR--------TLTG-------HSGGVNSVAFSPDGKLLaSGSDDGTVRLW----- 315

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564350803 442 cselvdclpkEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPK 496
Cdd:COG2319  316 ----------DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 455-493 1.50e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.50e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 564350803   455 PLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLY 493
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
49-496 2.27e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 2.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803  49 ASPPPATGSPRLRGSPAVSPAERAGELAAPEALELSAAASQAELSPSSSPRRRSRPDCKAGSWSRQGLSAGLGGPGARLF 128
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803 129 GWLRERSLGRGLFVDPARDNFRTMTNLYGSIHPAdsvyLSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIK 208
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLR----TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803 209 TLSeAHEDCVNNIRCTEDGcphkkffhtrflmrmrltpdcsKMLISTSSGYLLILHDLD---LTKSLEVGSYPILRArrt 285
Cdd:COG2319  157 TLT-GHSGAVTSVAFSPDG----------------------KLLASGSDDGTVRLWDLAtgkLLRTLTGHTGAVRSV--- 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803 286 tsssdlttsssssgsrvsgspCHHNDSnsteKHVSRASQREGV---SPRNSLEVLTPevpgeRDRGNCITSLQLHPKGwA 362
Cdd:COG2319  211 ---------------------AFSPDG----KLLASGSADGTVrlwDLATGKLLRTL-----TGHSGSVRSVAFSPDG-R 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350803 363 TLLrcsSNTDDQEwTCVYEFQEGAPVRpvsprcslRLTHyieeanvGRGYIKELCFSPDGRMI-SSPHGYGIRLLgfdkq 441
Cdd:COG2319  260 LLA---SGSADGT-VRLWDLATGELLR--------TLTG-------HSGGVNSVAFSPDGKLLaSGSDDGTVRLW----- 315

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564350803 442 cselvdclpkEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPK 496
Cdd:COG2319  316 ----------DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 455-493 1.50e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.50e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 564350803   455 PLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLY 493
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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