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Conserved domains on  [gi|564350065|ref|XP_006237844|]
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minichromosome maintenance domain-containing protein 2 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MCM_lid super family cl39337
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
546-630 1.10e-09

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


The actual alignment was detected with superfamily member pfam17855:

Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 55.63  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065  546 EDFEKLLAFAK-NLNVEFSLEAERMIHGYYLASRRIRTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDVLIAAL 624
Cdd:pfam17855   1 ELLRKYIAYAReKIKPKLSEEAREKLVDAYVELRKESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIR 80

                  ....*.
gi 564350065  625 LFEISL 630
Cdd:pfam17855  81 LLKESL 86
MCM super family cl28901
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
403-629 1.35e-08

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


The actual alignment was detected with superfamily member cd17760:

Pssm-ID: 475121 [Multi-domain]  Cd Length: 299  Bit Score: 56.79  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 403 IQAGSALLARGGVCFIGDLTSHKKDKLEQLQSALESRSVTVFIPGkkfgddfdQQMTFPIQCSFWSFV------DMDSSS 476
Cdd:cd17760   94 LEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAG--------LVCKLNTRTTILAATnpkgqyDPNESI 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 477 RRNVQKASTLIGQMDCSLIpanlaeafglLVNCKESSPCHPLLptvqhtlKKAVDPKGPPYLASKQFTTEDFEKLLAFAK 556
Cdd:cd17760  166 SVNIALASPLLSRFDLVLV----------LLDTKNEDWDRIIS-------SFILENKGEPSKSSKLWSMEKMRTYFCLIK 228
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564350065 557 NLNVEFSLEAERMIHGYYLASRRirTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDVLIAALLFEIS 629
Cdd:cd17760  229 NLRPVLSDEANAILLRYYQLQRQ--SDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
 
Name Accession Description Interval E-value
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
546-630 1.10e-09

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 55.63  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065  546 EDFEKLLAFAK-NLNVEFSLEAERMIHGYYLASRRIRTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDVLIAAL 624
Cdd:pfam17855   1 ELLRKYIAYAReKIKPKLSEEAREKLVDAYVELRKESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIR 80

                  ....*.
gi 564350065  625 LFEISL 630
Cdd:pfam17855  81 LLKESL 86
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
403-629 1.35e-08

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 56.79  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 403 IQAGSALLARGGVCFIGDLTSHKKDKLEQLQSALESRSVTVFIPGkkfgddfdQQMTFPIQCSFWSFV------DMDSSS 476
Cdd:cd17760   94 LEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAG--------LVCKLNTRTTILAATnpkgqyDPNESI 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 477 RRNVQKASTLIGQMDCSLIpanlaeafglLVNCKESSPCHPLLptvqhtlKKAVDPKGPPYLASKQFTTEDFEKLLAFAK 556
Cdd:cd17760  166 SVNIALASPLLSRFDLVLV----------LLDTKNEDWDRIIS-------SFILENKGEPSKSSKLWSMEKMRTYFCLIK 228
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564350065 557 NLNVEFSLEAERMIHGYYLASRRirTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDVLIAALLFEIS 629
Cdd:cd17760  229 NLRPVLSDEANAILLRYYQLQRQ--SDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
390-630 4.33e-07

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 53.26  E-value: 4.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 390 TVSRDKYGTGAVSIQAGSALLARGGVCFIGDLTSHKKDKLEQLQSALESRSVTVFIPG----------------KKFGDd 453
Cdd:COG1241  358 AAVRDDFGTGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGivatlnarcsvlaaanPKYGR- 436
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 454 FDQQMTFPIQcsfwsfVDMDSssrrnvqkasTLIGQMDcsLI------P-----ANLAEAfgLLVNCKESSPCHPLLPTV 522
Cdd:COG1241  437 FDPYEPIAEQ------IDLPP----------TLLSRFD--LIfvlrdkPdeerdRELARH--ILKVHRAGELLEQEIEEE 496
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 523 QHTLKKAVDPkgppylaskqfttEDFEKLLAFAK-NLNVEFSLEAERMIHGYYLASRRIRTDSIHGSKLSANALKYLVSL 601
Cdd:COG1241  497 TEEVKPEIDP-------------DLLRKYIAYARrNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPVPITARQLEALIRL 563
                        250       260
                 ....*....|....*....|....*....
gi 564350065 602 SEAHARLNLRNKVLREDVLIAALLFEISL 630
Cdd:COG1241  564 AEASARMRLSDTVTEEDAERAIRLVDSCL 592
MCM smart00350
minichromosome maintenance proteins;
537-630 7.51e-04

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 42.63  E-value: 7.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065   537 YLASKQFTTEDFEKLL---------AFAK-NLNVEFSLEAERMIHGYYLASRRIrtDSIHGSKLS----ANALKYLVSLS 602
Cdd:smart00350 403 HRYSHPEEDEAFEPPLsqeklrkyiAYAReKIKPKLSEEAADKLVKAYVDLRKE--DSQTESRSSipitVRQLESIIRLS 480
                           90       100
                   ....*....|....*....|....*...
gi 564350065   603 EAHARLNLRNKVLREDVLIAALLFEISL 630
Cdd:smart00350 481 EAHAKMRLSDVVEEADVEEAIRLLRESI 508
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
552-625 1.93e-03

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 40.88  E-value: 1.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564350065 552 LAFAK-NLNVEFSLEAERMIHGYYLASRRIrtDSIHGSKLSANA--LKYLVSLSEAHARLNLRNKVLREDVLIAALL 625
Cdd:cd17755  231 ISYAReHIHPKLSEEAAQELVQAYVDMRKM--GSDARKRITATPrqLESLIRLAEAHAKMRLSNVVEAEDVEEAVRL 305
 
Name Accession Description Interval E-value
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
546-630 1.10e-09

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 55.63  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065  546 EDFEKLLAFAK-NLNVEFSLEAERMIHGYYLASRRIRTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDVLIAAL 624
Cdd:pfam17855   1 ELLRKYIAYAReKIKPKLSEEAREKLVDAYVELRKESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIR 80

                  ....*.
gi 564350065  625 LFEISL 630
Cdd:pfam17855  81 LLKESL 86
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
403-629 1.35e-08

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 56.79  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 403 IQAGSALLARGGVCFIGDLTSHKKDKLEQLQSALESRSVTVFIPGkkfgddfdQQMTFPIQCSFWSFV------DMDSSS 476
Cdd:cd17760   94 LEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAG--------LVCKLNTRTTILAATnpkgqyDPNESI 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 477 RRNVQKASTLIGQMDCSLIpanlaeafglLVNCKESSPCHPLLptvqhtlKKAVDPKGPPYLASKQFTTEDFEKLLAFAK 556
Cdd:cd17760  166 SVNIALASPLLSRFDLVLV----------LLDTKNEDWDRIIS-------SFILENKGEPSKSSKLWSMEKMRTYFCLIK 228
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564350065 557 NLNVEFSLEAERMIHGYYLASRRirTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDVLIAALLFEIS 629
Cdd:cd17760  229 NLRPVLSDEANAILLRYYQLQRQ--SDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
390-629 2.90e-08

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 55.81  E-value: 2.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 390 TVSRDKyGTGAVSIQAGSALLARGGVCFIGDLTSHKKDKLEQLQSALESRSVTVfipgKKFGDDfdqqMTFPIQCSF--- 466
Cdd:cd17706   84 AVVRDS-ETGEWYLEAGALVLADGGVCCIDEFDKMKELDRTALHEAMEQQTISI----AKAGIV----TTLNARCSIlaa 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 467 ----WSFVDMDSSSRRNVQKASTLIGQMDcsLIpanlaeaFGLLVNCKE----SSPCHPLLPTVQHTLKKAVDPKGPPYL 538
Cdd:cd17706  155 anpkGGRYNPKLSPIENINLPSPLLSRFD--LI-------FVIRDDPDEerdeELAEHIIDLHRGSDPEEQVKPEEDGIP 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 539 ASKQFTTedfeKLLAFAKNLNVEFSLEAERMIHGYYLasrRIRTDSIHGSKLSANA--LKYLVSLSEAHARLNLRNKVLR 616
Cdd:cd17706  226 IDIELLR----KYILYARQIHPKISEEAREKLVRWYV---ELRKESERRSTIPITArqLESVIRLAEAHAKMRLSEVVTE 298
                        250
                 ....*....|...
gi 564350065 617 EDVLIAALLFEIS 629
Cdd:cd17706  299 EDVEEAIRLVRHS 311
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
390-629 1.50e-07

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 53.53  E-value: 1.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 390 TVSRDKyGTGAVSIQAGSALLARGGVCFIGDLtshkkDKLEQ-----LQSALESRSVTVfipgKKFGddfdQQMTF---- 460
Cdd:cd17757   84 AVVRDE-ETGDFVIEAGALMLADNGICCIDEF-----DKMDIkdqvaIHEAMEQQTISI----TKAG----IQATLnart 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 461 -------PIQCSFwsfvDMDSSSRRNVQKASTLIGQMDCslipanlaeAFGLLVNCKESSPCH--PLLPTVQHTLKKAVD 531
Cdd:cd17757  150 silaaanPVGGRY----DRSKSLKQNINISAPIMSRFDL---------FFVLLDECNEVTDYAiaSHIVDLHSKREEAIE 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 532 PkgppylaskQFTTEDFEKLLAFAKNLNVEFSLEAERMIHGYYLASRRIRTDSIHGS--KLSANALKYLVSLSEAHARLN 609
Cdd:cd17757  217 P---------PFTAEQLKRYIAYARTFKPKLTKEAKDELVEQYKELRQDDASGSTRSsyRITVRQLESLIRLSEAIARLH 287
                        250       260
                 ....*....|....*....|
gi 564350065 610 LRNKVLREDVLIAALLFEIS 629
Cdd:cd17757  288 CSDEVTPEHVEEAARLLKKS 307
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
390-630 4.33e-07

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 53.26  E-value: 4.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 390 TVSRDKYGTGAVSIQAGSALLARGGVCFIGDLTSHKKDKLEQLQSALESRSVTVFIPG----------------KKFGDd 453
Cdd:COG1241  358 AAVRDDFGTGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGivatlnarcsvlaaanPKYGR- 436
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 454 FDQQMTFPIQcsfwsfVDMDSssrrnvqkasTLIGQMDcsLI------P-----ANLAEAfgLLVNCKESSPCHPLLPTV 522
Cdd:COG1241  437 FDPYEPIAEQ------IDLPP----------TLLSRFD--LIfvlrdkPdeerdRELARH--ILKVHRAGELLEQEIEEE 496
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 523 QHTLKKAVDPkgppylaskqfttEDFEKLLAFAK-NLNVEFSLEAERMIHGYYLASRRIRTDSIHGSKLSANALKYLVSL 601
Cdd:COG1241  497 TEEVKPEIDP-------------DLLRKYIAYARrNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPVPITARQLEALIRL 563
                        250       260
                 ....*....|....*....|....*....
gi 564350065 602 SEAHARLNLRNKVLREDVLIAALLFEISL 630
Cdd:COG1241  564 AEASARMRLSDTVTEEDAERAIRLVDSCL 592
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
390-619 5.62e-06

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 48.99  E-value: 5.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 390 TVSRDKyGTGAVSIQAGSALLARGGVCFIGDLTSHKKDKLEQLQSALESRSVTVFIPG----------------KKFGDd 453
Cdd:cd17761   85 AVVRDE-GTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGivatlnaraavlaaanPKFGR- 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 454 FDQQMTFPIQcsfwsfVDMdsssrrnvqkASTLIGQMDCSLIPANLAEAfgllvnCKESSPCHPLLPTvqHTLK--KAVD 531
Cdd:cd17761  163 FDSYRPVAEQ------IDL----------PPTLLSRFDLIFVLKDTPNE------EKDRRLANHILDT--HSGGemREIK 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 532 PKGPPYLaskqfttedFEKLLAFA-KNLNVEFSLEAERMIHGYYLASRRIRTDSIHGSKLSANALKYLVSLSEAHARLNL 610
Cdd:cd17761  219 PEIDPDL---------LRKYIAYArKNVRPVLTEEAKQLIKDFYVEMRKSGQETPSPVPITARQLEALVRLSEASARMRL 289

                 ....*....
gi 564350065 611 RNKVLREDV 619
Cdd:cd17761  290 SQEVTLEDA 298
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
390-619 4.58e-05

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 45.99  E-value: 4.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 390 TVSRDKYgTGAVSIQAGSALLARGGVCFIGDLtshkkDKLEQLQSAL----ESRSVTVFIPGkkfgddfdqqmtfpIQCS 465
Cdd:cd17759   86 TLTKDGR-SGDFALEAGALVLGDQGICGIDEF-----DKMGSQHQALleamEQQSVSLAKAG--------------VVCS 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 466 F---WSFVDMDSSSRRNVQKASTLIGQMDCSliPANLAEAFGLLVNCKESSPCHPLLPTVQHTLKKavdpkgppylaskq 542
Cdd:cd17759  146 LparTSVIAAANPVGGHYNKGKTVSENLKMG--PALLSRFDLVFILLDTPSEEHDHLLSEHHQLLR-------------- 209
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564350065 543 fttedfeKLLAFAK-NLNVEFSLEAERMIHGYYLASRRiRTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDV 619
Cdd:cd17759  210 -------KYISYARqYVNPVLSKDASEALQEFYLELRK-QNQLADSSPITTRQLESLIRLTEARARLELREEATKEDA 279
MCM smart00350
minichromosome maintenance proteins;
537-630 7.51e-04

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 42.63  E-value: 7.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065   537 YLASKQFTTEDFEKLL---------AFAK-NLNVEFSLEAERMIHGYYLASRRIrtDSIHGSKLS----ANALKYLVSLS 602
Cdd:smart00350 403 HRYSHPEEDEAFEPPLsqeklrkyiAYAReKIKPKLSEEAADKLVKAYVDLRKE--DSQTESRSSipitVRQLESIIRLS 480
                           90       100
                   ....*....|....*....|....*...
gi 564350065   603 EAHARLNLRNKVLREDVLIAALLFEISL 630
Cdd:smart00350 481 EAHAKMRLSDVVEEADVEEAIRLLRESI 508
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
391-629 1.77e-03

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 40.86  E-value: 1.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 391 VSRDKyGTGAVSIQAGSALLARGGVCFIGDLtshkkDKLEQ-----LQSALESRSVTVfipgKKFGddfdQQMTFPIQCS 465
Cdd:cd17758   84 VMKDP-VTGEMTLEGGALVLADQGICCIDEF-----DKMDEsdrtaIHEVMEQQTISI----AKAG----ITTTLNARTS 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 466 FwsfvdmdsssrrnVQKASTLIGQMDCSL-------IPANLAEAFGLLVNCKESSPCHPLLPTVQHTL---KKAVDPkgp 535
Cdd:cd17758  150 I-------------LAAANPAYGRYNPRRspeqninLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTyvhQHNKQP--- 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350065 536 pYLASKQFTTEDFEKLLAFAKNLNVEFSLEAERMIHGYYLASRRIRTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVL 615
Cdd:cd17758  214 -DSDFEPLDPKLLRAYIALAKRKRPTVPPALADYIVQAYVEMRQEAKRSKDFTFTTPRTLLAILRLSQALARLRLSDSVE 292
                        250
                 ....*....|....
gi 564350065 616 REDVLIAALLFEIS 629
Cdd:cd17758  293 IDDVEEALRLMEMS 306
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
552-625 1.93e-03

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 40.88  E-value: 1.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564350065 552 LAFAK-NLNVEFSLEAERMIHGYYLASRRIrtDSIHGSKLSANA--LKYLVSLSEAHARLNLRNKVLREDVLIAALL 625
Cdd:cd17755  231 ISYAReHIHPKLSEEAAQELVQAYVDMRKM--GSDARKRITATPrqLESLIRLAEAHAKMRLSNVVEAEDVEEAVRL 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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