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Conserved domains on  [gi|564347368|ref|XP_006236765|]
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intron Large complex component GCFC2 isoform X2 [Rattus norvegicus]

Protein Classification

GCFC domain-containing protein( domain architecture ID 10545165)

GCFC domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GCFC pfam07842
GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a ...
459-673 6.05e-37

GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a number of GC-rich sequence DNA-binding factor proteins and homologs, as well as in a number of other proteins including Tuftelin-interacting protein 11. While the function of the domain is unknown, some of the proteins it is found in are reported to be involved in pre-mRNA splicing. This domain is also found in Sip1, a septin interacting protein.


:

Pssm-ID: 400273  Cd Length: 275  Bit Score: 139.90  E-value: 6.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347368  459 VQNILLKFQQWREKFPDSYYEAFVGFCLPKLLSPLIRVQLLDWNPLKMDSMGLD-------------------------- 512
Cdd:pfam07842   1 LDEIADIFERLQRKYPEEYKEAELSLLAPSLVHPLLRLELLEWDPLKDPTYGVDilsrwrkllepdvssddtggresmdp 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347368  513 --RMPWFTAITEFMESGMEDVGKEDGSD-------------KKILSAVINKTVVPRLTDFVEmIWDPLSTSQTRILTVHC 577
Cdd:pfam07842  81 yeTMLWEGWLPSYRSSIISTWDPRDPDPmlalleawapllpSWILDNILEQLILPKLTAAVE-EWDPLSDTVTRNLVPIH 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347368  578 RVAFEQFASETEVSKskqDLLKSVAARMKKSIED---------------DVFIP-LYPKSSEEGKMSPHSKFQE------ 635
Cdd:pfam07842 160 SWIHPWLPLLGARLE---PLYPDIRRKLRQALDAwhpsrsalaglkpwkDVFSPgEWDKFLRRHILPKLALALQefvinp 236
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 564347368  636 RQfwGALKLFGNILLWNGLLPDDILQNLGLGKLLNRYL 673
Cdd:pfam07842 237 RQ--QSLELFRNVLKWKDLLPPSVLADLLEKEFFPKWL 272
 
Name Accession Description Interval E-value
GCFC pfam07842
GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a ...
459-673 6.05e-37

GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a number of GC-rich sequence DNA-binding factor proteins and homologs, as well as in a number of other proteins including Tuftelin-interacting protein 11. While the function of the domain is unknown, some of the proteins it is found in are reported to be involved in pre-mRNA splicing. This domain is also found in Sip1, a septin interacting protein.


Pssm-ID: 400273  Cd Length: 275  Bit Score: 139.90  E-value: 6.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347368  459 VQNILLKFQQWREKFPDSYYEAFVGFCLPKLLSPLIRVQLLDWNPLKMDSMGLD-------------------------- 512
Cdd:pfam07842   1 LDEIADIFERLQRKYPEEYKEAELSLLAPSLVHPLLRLELLEWDPLKDPTYGVDilsrwrkllepdvssddtggresmdp 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347368  513 --RMPWFTAITEFMESGMEDVGKEDGSD-------------KKILSAVINKTVVPRLTDFVEmIWDPLSTSQTRILTVHC 577
Cdd:pfam07842  81 yeTMLWEGWLPSYRSSIISTWDPRDPDPmlalleawapllpSWILDNILEQLILPKLTAAVE-EWDPLSDTVTRNLVPIH 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347368  578 RVAFEQFASETEVSKskqDLLKSVAARMKKSIED---------------DVFIP-LYPKSSEEGKMSPHSKFQE------ 635
Cdd:pfam07842 160 SWIHPWLPLLGARLE---PLYPDIRRKLRQALDAwhpsrsalaglkpwkDVFSPgEWDKFLRRHILPKLALALQefvinp 236
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 564347368  636 RQfwGALKLFGNILLWNGLLPDDILQNLGLGKLLNRYL 673
Cdd:pfam07842 237 RQ--QSLELFRNVLKWKDLLPPSVLADLLEKEFFPKWL 272
 
Name Accession Description Interval E-value
GCFC pfam07842
GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a ...
459-673 6.05e-37

GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a number of GC-rich sequence DNA-binding factor proteins and homologs, as well as in a number of other proteins including Tuftelin-interacting protein 11. While the function of the domain is unknown, some of the proteins it is found in are reported to be involved in pre-mRNA splicing. This domain is also found in Sip1, a septin interacting protein.


Pssm-ID: 400273  Cd Length: 275  Bit Score: 139.90  E-value: 6.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347368  459 VQNILLKFQQWREKFPDSYYEAFVGFCLPKLLSPLIRVQLLDWNPLKMDSMGLD-------------------------- 512
Cdd:pfam07842   1 LDEIADIFERLQRKYPEEYKEAELSLLAPSLVHPLLRLELLEWDPLKDPTYGVDilsrwrkllepdvssddtggresmdp 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347368  513 --RMPWFTAITEFMESGMEDVGKEDGSD-------------KKILSAVINKTVVPRLTDFVEmIWDPLSTSQTRILTVHC 577
Cdd:pfam07842  81 yeTMLWEGWLPSYRSSIISTWDPRDPDPmlalleawapllpSWILDNILEQLILPKLTAAVE-EWDPLSDTVTRNLVPIH 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347368  578 RVAFEQFASETEVSKskqDLLKSVAARMKKSIED---------------DVFIP-LYPKSSEEGKMSPHSKFQE------ 635
Cdd:pfam07842 160 SWIHPWLPLLGARLE---PLYPDIRRKLRQALDAwhpsrsalaglkpwkDVFSPgEWDKFLRRHILPKLALALQefvinp 236
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 564347368  636 RQfwGALKLFGNILLWNGLLPDDILQNLGLGKLLNRYL 673
Cdd:pfam07842 237 RQ--QSLELFRNVLKWKDLLPPSVLADLLEKEFFPKWL 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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