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Conserved domains on  [gi|564342410|ref|XP_006234841|]
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leucine-rich repeat-containing protein 57 isoform X2 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-225 1.38e-29

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 114.26  E-value: 1.38e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  38 SNLRTIDLSNNKIDSLPPlIIGKFTLLKSLSLNNNKLTVLPDELCNLKKLETLSLNNNHLRELPSSFGQLSALKTLSLSG 117
Cdd:COG4886  113 TNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410 118 NQLGALPPQLCSLRHLDVVDLSKNQIRSIPDTVGELQAIE-LNLNQNQISQISVrISCCPRLKVLRLEENclELSMLPQS 196
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLEtLDLSNNQLTDLPE-LGNLTNLEELDLSNN--QLTDLPPL 268

                        170       180
                 ....*....|....*....|....*....
gi 564342410 197 iLSDSQICLLAVEGNLFEIKKLRELEGYD 225
Cdd:COG4886  269 -ANLTNLKTLDLSNNQLTDLKLKELELLL 296
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-225 1.38e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 114.26  E-value: 1.38e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  38 SNLRTIDLSNNKIDSLPPlIIGKFTLLKSLSLNNNKLTVLPDELCNLKKLETLSLNNNHLRELPSSFGQLSALKTLSLSG 117
Cdd:COG4886  113 TNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410 118 NQLGALPPQLCSLRHLDVVDLSKNQIRSIPDTVGELQAIE-LNLNQNQISQISVrISCCPRLKVLRLEENclELSMLPQS 196
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLEtLDLSNNQLTDLPE-LGNLTNLEELDLSNN--QLTDLPPL 268

                        170       180
                 ....*....|....*....|....*....
gi 564342410 197 iLSDSQICLLAVEGNLFEIKKLRELEGYD 225
Cdd:COG4886  269 -ANLTNLKTLDLSNNQLTDLKLKELELLL 296
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
21-211 2.03e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.81  E-value: 2.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  21 LKDRGLTEFPSELQKltsNLRTIDLSNNKIDSLPPLIIGKftlLKSLSLNNNKLTVLPDELCNlkKLETLSLNNNHLREL 100
Cdd:PRK15370 185 LKILGLTTIPACIPE---QITTLILDNNELKSLPENLQGN---IKTLYANSNQLTSIPATLPD--TIQEMELSINRITEL 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410 101 PSSFGqlSALKTLSLSGNQLGALPPQLC-SLRHLDVVDlskNQIRSIPDTVGElQAIELNLNQNQISQISVRISccPRLK 179
Cdd:PRK15370 257 PERLP--SALQSLDLFHNKISCLPENLPeELRYLSVYD---NSIRTLPAHLPS-GITHLNVQSNSLTALPETLP--PGLK 328

                        170       180       190
                 ....*....|....*....|....*....|..
gi 564342410 180 VLRLEENCleLSMLPQSILSDSQIclLAVEGN 211
Cdd:PRK15370 329 TLEAGENA--LTSLPASLPPELQV--LDVSKN 356
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 21-188 3.18e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.35  E-value: 3.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  21 LKDRGLTEFpsELQKLTSNLRTIDLSNNKIDSLPPLiiGKFTLLKSLSLNNNKLTVLpDELCNLKKLETLSLNNNHLREL 100
Cdd:cd21340    9 LNDKNITKI--DNLSLCKNLKVLYLYDNKITKIENL--EFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410 101 pSSFGQLSALKTLSLSGNQLgALPPQLC-----------SLRHLDVvdlSKNQIRSIPDtVGELQAIE-LNLNQNQIS-- 166
Cdd:cd21340   84 -EGLENLTNLEELHIENQRL-PPGEKLTfdprslaalsnSLRVLNI---SGNNIDSLEP-LAPLRNLEqLDASNNQISdl 157

                        170       180
                 ....*....|....*....|...
gi 564342410 167 -QISVRISCCPRLKVLRLEENCL 188
Cdd:cd21340  158 eELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
38-97 1.93e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.93e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564342410   38 SNLRTIDLSNNKIDSLPPLIIGKFTLLKSLSLNNNKLTVL-PDELCNLKKLETLSLNNNHL 97
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-225 1.38e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 114.26  E-value: 1.38e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  38 SNLRTIDLSNNKIDSLPPlIIGKFTLLKSLSLNNNKLTVLPDELCNLKKLETLSLNNNHLRELPSSFGQLSALKTLSLSG 117
Cdd:COG4886  113 TNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410 118 NQLGALPPQLCSLRHLDVVDLSKNQIRSIPDTVGELQAIE-LNLNQNQISQISVrISCCPRLKVLRLEENclELSMLPQS 196
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLEtLDLSNNQLTDLPE-LGNLTNLEELDLSNN--QLTDLPPL 268

                        170       180
                 ....*....|....*....|....*....
gi 564342410 197 iLSDSQICLLAVEGNLFEIKKLRELEGYD 225
Cdd:COG4886  269 -ANLTNLKTLDLSNNQLTDLKLKELELLL 296
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
21-221 1.10e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.56  E-value: 1.10e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  21 LKDRGLTEFPSELQKLTsNLRTIDLSNNKIDSLPPlIIGKFTLLKSLSLNNNKLTVLPDELCNLKKLETLSLNNNHLREL 100
Cdd:COG4886  143 LSNNQLTDLPEPLGNLT-NLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410 101 PSSFGQLSALKTLSLSGNQLGALPpQLCSLRHLDVVDLSKNQIRSIPDTVGELQAIELNLNQNQISQISVRISCCPRLKV 180
Cdd:COG4886  221 PEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 564342410 181 LRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLREL 221
Cdd:COG4886  300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
21-211 2.03e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.81  E-value: 2.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  21 LKDRGLTEFPSELQKltsNLRTIDLSNNKIDSLPPLIIGKftlLKSLSLNNNKLTVLPDELCNlkKLETLSLNNNHLREL 100
Cdd:PRK15370 185 LKILGLTTIPACIPE---QITTLILDNNELKSLPENLQGN---IKTLYANSNQLTSIPATLPD--TIQEMELSINRITEL 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410 101 PSSFGqlSALKTLSLSGNQLGALPPQLC-SLRHLDVVDlskNQIRSIPDTVGElQAIELNLNQNQISQISVRISccPRLK 179
Cdd:PRK15370 257 PERLP--SALQSLDLFHNKISCLPENLPeELRYLSVYD---NSIRTLPAHLPS-GITHLNVQSNSLTALPETLP--PGLK 328

                        170       180       190
                 ....*....|....*....|....*....|..
gi 564342410 180 VLRLEENCleLSMLPQSILSDSQIclLAVEGN 211
Cdd:PRK15370 329 TLEAGENA--LTSLPASLPPELQV--LDVSKN 356
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-188 3.66e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.11  E-value: 3.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  38 SNLRTIDLSNNKIDSLPPLIIGKFTLLKSLSLNNNKLT-VLPDELCNLKKLETLSLNNNHLR-ELPSSFGQLSALKTLSL 115
Cdd:PLN00113 140 PNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYL 219

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564342410 116 SGNQL-GALPPQ---LCSLRHLDVVdlSKNQIRSIPDTVGELQAIE-LNLNQNQIS-QISVRISCCPRLKVLRLEENCL 188
Cdd:PLN00113 220 GYNNLsGEIPYEiggLTSLNHLDLV--YNNLTGPIPSSLGNLKNLQyLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-156 2.69e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.80  E-value: 2.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  37 TSNLRTIDLSNNKIDSLPPLIIGKFTLLKSLSLNNNKLT-VLPDELCNLKKLETLSLNNNHLR-ELPSSFGQLSALKTLS 114
Cdd:PLN00113 474 SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLD 553

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564342410 115 LSGNQL-GALPPQLCSLRHLDVVDLSKNQIR-SIPDTvGELQAI 156
Cdd:PLN00113 554 LSQNQLsGEIPKNLGNVESLVQVNISHNHLHgSLPST-GAFLAI 596
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 21-188 3.18e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.35  E-value: 3.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  21 LKDRGLTEFpsELQKLTSNLRTIDLSNNKIDSLPPLiiGKFTLLKSLSLNNNKLTVLpDELCNLKKLETLSLNNNHLREL 100
Cdd:cd21340    9 LNDKNITKI--DNLSLCKNLKVLYLYDNKITKIENL--EFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410 101 pSSFGQLSALKTLSLSGNQLgALPPQLC-----------SLRHLDVvdlSKNQIRSIPDtVGELQAIE-LNLNQNQIS-- 166
Cdd:cd21340   84 -EGLENLTNLEELHIENQRL-PPGEKLTfdprslaalsnSLRVLNI---SGNNIDSLEP-LAPLRNLEqLDASNNQISdl 157

                        170       180
                 ....*....|....*....|...
gi 564342410 167 -QISVRISCCPRLKVLRLEENCL 188
Cdd:cd21340  158 eELLDLLSSWPSLRELDLTGNPV 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
18-197 1.51e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 66.64  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  18 VFQLKDRGLTEFPselQKLTSNLRTIDLSNNKIDSLPPLIIGKftlLKSLSLNNNKLTVLPDELCNlkKLETLSLNNNHL 97
Cdd:PRK15370 245 EMELSINRITELP---ERLPSALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSL 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  98 RELPSSFGQlsALKTLSLSGNQLGALPPQLCSlrHLDVVDLSKNQIRSIPDTV-GELQaiELNLNQNQISQISVRISCCp 176
Cdd:PRK15370 317 TALPETLPP--GLKTLEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETLpPTIT--TLDVSRNALTNLPENLPAA- 389

                        170       180
                 ....*....|....*....|.
gi 564342410 177 rLKVLRLEENclELSMLPQSI 197
Cdd:PRK15370 390 -LQIMQASRN--NLVRLPESL 407
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
6-221 4.32e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 59.41  E-value: 4.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410   6 LRAHVETaqktgvFQLKDRGLTEFPSelqkLTSNLRTIDLSNNKIDSLPPLIIGkftlLKSLSLNNNKLT---VLPDELC 82
Cdd:PRK15387 220 LPAHITT------LVIPDNNLTSLPA----LPPELRTLEVSGNQLTSLPVLPPG----LLELSIFSNPLThlpALPSGLC 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  83 NL--------------KKLETLSLNNNHLRELPSSFGQL-----------------SALKTLSLSGNQLGALPP------ 125
Cdd:PRK15387 286 KLwifgnqltslpvlpPGLQELSVSDNQLASLPALPSELcklwaynnqltslptlpSGLQELSVSDNQLASLPTlpsely 365

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410 126 -------QLCSL----RHLDVVDLSKNQIRSIPDTVGELQaiELNLNQNQISQISVRISCCPRLKVLRleencLELSMLP 194
Cdd:PRK15387 366 klwaynnRLTSLpalpSGLKELIVSGNRLTSLPVLPSELK--ELMVSGNRLTSLPMLPSGLLSLSVYR-----NQLTRLP 438

                        250       260
                 ....*....|....*....|....*..
gi 564342410 195 QSILSDSQICLLAVEGNLFEIKKLREL 221
Cdd:PRK15387 439 ESLIHLSSETTVNLEGNPLSERTLQAL 465
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-166 1.34e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 1.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  26 LTEFPSELQKLTsNLRTIDLSNNKIDSLPPLiiGKFTLLKSLSLNNNKLTVLPdELCNLKKLETLSLNNNHLRELPSSFG 105
Cdd:COG4886  217 LTDLPEPLANLT-NLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKEL 292

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564342410 106 QLSALKTLSLSGNQLGALPPQLCSLRHLDVVDLSKNQIRSIPDTVGELQAIELNLNQNQIS 166
Cdd:COG4886  293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLL 353
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-197 5.07e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 5.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  33 LQKLTSNLRTIDLSNNKIDSLPPLIIGKFTLLKSLSLNNNKLTVLPDELCNLKKLETLSLNNNHLRELPSSFGQLSALKT 112
Cdd:COG4886   21 LTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410 113 LS-----------------LSGNQLGALPPQLCSLRHLDVVDLSKNQIRSIPDTVGELQAIE-LNLNQNQISQISVRISC 174
Cdd:COG4886  101 LDlsgneelsnltnlesldLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKsLDLSNNQLTDLPEELGN 180

                        170       180
                 ....*....|....*....|...
gi 564342410 175 CPRLKVLRLEENclELSMLPQSI 197
Cdd:COG4886  181 LTNLKELDLSNN--QITDLPEPL 201
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
4-131 1.32e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.70  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410   4 SALRAHVetaqKTGVFQL--KDRGLTEFPselQKLTSNLRTIDLSNNKIDSLPPLIIGKftlLKSLSLNNNKLTVLPDEL 81
Cdd:PRK15370 296 RTLPAHL----PSGITHLnvQSNSLTALP---ETLPPGLKTLEAGENALTSLPASLPPE---LQVLDVSKNQITVLPETL 365

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564342410  82 CnlKKLETLSLNNNHLRELPSSFGqlSALKTLSLSGNQLGALPPQLCSLR 131
Cdd:PRK15370 366 P--PTITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLPESLPHFR 411
LRR_8 pfam13855
Leucine rich repeat;
38-97 1.93e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.93e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564342410   38 SNLRTIDLSNNKIDSLPPLIIGKFTLLKSLSLNNNKLTVL-PDELCNLKKLETLSLNNNHL 97
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 33-166 5.16e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.93  E-value: 5.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  33 LQKLTSnlrtIDLSNNKIDSLPPLIIGKFTLLKSLSLNNNKLT-VLPDELCNLKKLETLSLNNNHLR-ELPSSFGQLSAL 110
Cdd:PLN00113 283 LQKLIS----LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNL 358

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564342410 111 KTLSLSGNQL-GALPPQLCSLRHLDVVDLSKNQIRS-IPDTVGELQAIE-LNLNQNQIS 166
Cdd:PLN00113 359 TVLDLSTNNLtGEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRrVRLQDNSFS 417
PLN03150 PLN03150
hypothetical protein; Provisional
 21-105 7.10e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.51  E-value: 7.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  21 LKDRGLTEF-PSELQKLtSNLRTIDLSNNKIDSLPPLIIGKFTLLKSLSLNNNKLT-VLPDELCNLKKLETLSLNNNHLR 98
Cdd:PLN03150 425 LDNQGLRGFiPNDISKL-RHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLS 503


                 ....*...
gi 564342410  99 -ELPSSFG 105
Cdd:PLN03150 504 gRVPAALG 511
LRR_8 pfam13855
Leucine rich repeat;
64-120 9.71e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 9.71e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 564342410   64 LKSLSLNNNKLTVLPDE-LCNLKKLETLSLNNNHLREL-PSSFGQLSALKTLSLSGNQL 120
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 18-188 1.51e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  18 VFQLKDRGLT-EFPSELQKlTSNLRTIDLSNNKIDS-LPPLIIGKFTLLKSLSLNNNKLTVLPDELCNLKKLETLSLNNN 95
Cdd:PLN00113 336 VLQLWSNKFSgEIPKNLGK-HNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  96 HLR-ELPSSFGQL------------------------SALKTLSLSGNQLGALPPQLCSLRHLDVVDLSKNQIR-SIPDT 149
Cdd:PLN00113 415 SFSgELPSEFTKLplvyfldisnnnlqgrinsrkwdmPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRK 494

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 564342410 150 VGELQAI-ELNLNQNQIS-QISVRISCCPRLKVLRLEENCL 188
Cdd:PLN00113 495 LGSLSELmQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQL 535
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 23-191 2.96e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 2.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  23 DRGLTEFPSELQKlTSNLRTIDLSNNKI--DSLPPLI-IGKFTLLKSLSLNNNKL---------TVLPDELCNLKK--LE 88
Cdd:cd00116   67 PRGLQSLLQGLTK-GCGLQELDLSDNALgpDGCGVLEsLLRSSSLQELKLNNNGLgdrglrllaKGLKDLPPALEKlvLG 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  89 TLSLNNNHLRELPSSFGQLSALKTLSLSGNQLG-----ALPPQLCSLRHLDVVDLSKNQIRS-----IPDTVGELQAIE- 157
Cdd:cd00116  146 RNRLEGASCEALAKALRANRDLKELNLANNGIGdagirALAEGLKANCNLEVLDLNNNGLTDegasaLAETLASLKSLEv 225

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 564342410 158 LNLNQNQISQISVR------ISCCPRLKVLRLEENCLELS 191
Cdd:cd00116  226 LNLGDNNLTDAGAAalasalLSPNISLLTLSLSCNDITDD 265
PLN03150 PLN03150
hypothetical protein; Provisional
 43-127 7.20e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.43  E-value: 7.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  43 IDLSNNKIDSLPPLIIGKFTLLKSLSLNNNKLT-VLPDELCNLKKLETLSLNNNHLR-ELPSSFGQLSALKTLSLSGNQL 120
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                 ....*...
gi 564342410 121 -GALPPQL 127
Cdd:PLN03150 503 sGRVPAAL 510
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-166 7.25e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 7.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  23 DRGLTEFPSELQKLTSnLRTIDLSNNKIDSLPPLIIGKF----TLLKSLSLNNNKLTV-----LPDELCNLKKLETLSLN 93
Cdd:COG5238  222 DEGAEILAEALKGNKS-LTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLS 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  94 NNHLRE-----LPSSFGQLSALKTLSLSGNQLG-----ALPPQLCSLRHLDVVDLSKNQIRS------IPDTVGELQAIE 157
Cdd:COG5238  301 VNRIGDegaiaLAEGLQGNKTLHTLNLAYNGIGaqgaiALAKALQENTTLHSLDLSDNQIGDegaialAKYLEGNTTLRE 380


                 ....*....
gi 564342410 158 LNLNQNQIS 166
Cdd:COG5238  381 LNLGKNNIG 389
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-188 2.14e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 2.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  37 TSNLRTIDLSNNKIDSLPPLIIGKFTLLKSLSLNNNKLT-VLPDELCNL-KKLETLSLNNNHLRElPSSFGQLSALKTLS 114
Cdd:PLN00113  68 SSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTG-SIPRGSIPNLETLD 146

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564342410 115 LSGNQL-GALPPQLCSLRHLDVVDLSKNQIRS-IPDTVGELQAIE-LNLNQNQ-ISQISVRISCCPRLKVLRLEENCL 188
Cdd:PLN00113 147 LSNNMLsGEIPNDIGSFSSLKVLDLGGNVLVGkIPNSLTNLTSLEfLTLASNQlVGQIPRELGQMKSLKWIYLGYNNL 224
LRR_8 pfam13855
Leucine rich repeat;
86-143 9.72e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 9.72e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410   86 KLETLSLNNNHLREL-PSSFGQLSALKTLSLSGNQLGALPPQ-LCSLRHLDVVDLSKNQI 143
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 20-170 1.04e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.94  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  20 QLKDRGLTEFPSELQKLTsNLRTIDLSNNKIDSLPPLIIGK----FTLLKSLSLNNNKLT-----VLPDELCNLKKLETL 90
Cdd:COG5238  191 QIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEalkgNKSLTTLDLSNNQIGdegviALAEALKNNTTVETL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  91 SLNNNHLRE-----LPSSFGQLSALKTLSLSGNQLG-----ALPPQLCSLRHLDVVDLSKNQI-----RSIPDTVGELQA 155
Cdd:COG5238  270 YLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIGdegaiALAEGLQGNKTLHTLNLAYNGIgaqgaIALAKALQENTT 349

                        170
                 ....*....|....*.
gi 564342410 156 IE-LNLNQNQISQISV 170
Cdd:COG5238  350 LHsLDLSDNQIGDEGA 365
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
31-137 5.33e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.92  E-value: 5.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  31 SELQKLTSNLRTIDLSNNKIDSLPPLIIGkftlLKSLSLNNNKLTVLPDELCNLKKLETLSLNNN--------HLRELPS 102
Cdd:PRK15387 395 TSLPVLPSELKELMVSGNRLTSLPMLPSG----LLSLSVYRNQLTRLPESLIHLSSETTVNLEGNplsertlqALREITS 470

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564342410 103 SFGQLSALKTLSLSgnqlGALPPQLCSLRHLDVVD 137
Cdd:PRK15387 471 APGYSGPIIRFDMA----GASAPRETRALHLAAAD 501
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 28-120 1.06e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  28 EFPSELQKlTSNLRTIDLSNNKIDSLPPLIIGKFTLLKSLSLNNNKLT-VLPDELCNLKKLETLSLNNNHLR-ELPSSfG 105
Cdd:PLN00113 514 EIPDELSS-CKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPST-G 591

                         90
                 ....*....|....*
gi 564342410 106 QLSALKTLSLSGNQL 120
Cdd:PLN00113 592 AFLAINASAVAGNID 606
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 84-222 1.12e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342410  84 LKKLETLSLNNNHLRELPsSFGQLSALKTLSLSGNQLGALpPQLCSLRHLDVVDLSKNQIRSIPDTVGELQAIELNLNQN 163
Cdd:cd21340    1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGN 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564342410 164 QISQISvRISCCPRLKVLRLEENCLELSML----PQSILSDSQ-ICLLAVEGN----LFEIKKLRELE 222
Cdd:cd21340   79 RISVVE-GLENLTNLEELHIENQRLPPGEKltfdPRSLAALSNsLRVLNISGNnidsLEPLAPLRNLE 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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