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Conserved domains on  [gi|564339595|ref|XP_006233690|]
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F-box/WD repeat-containing protein 5 isoform X2 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 17591517)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
372-464 7.48e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 7.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595 372 VFDLKTMREVkRALRAHR------AYTPNDEcffifldvsrdFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFS 444
Cdd:COG2319  314 LWDLATGKLL-RTLTGHTgavrsvAFSPDGK-----------TLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFS 381

                         90       100
                 ....*....|....*....|
gi 564339595 445 PQEQeLLLTASDDATIKAWR 464
Cdd:COG2319  382 PDGR-TLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-42 1.21e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.21e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564339595     7 VQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 super family cl43672
WD40 repeat [General function prediction only];
6-113 3.39e-05

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 3.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595   6 EVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWNNDlTISLLHSADMRPYNWSYTQFSqfnqDDSLLLASGvflgph 85
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFS----PDGKLLASG------ 306

                         90       100
                 ....*....|....*....|....*...
gi 564339595  86 nSSSGEIAVISLDSFALLSRVRNKPYDV 113
Cdd:COG2319  307 -SDDGTVRLWDLATGKLLRTLTGHTGAV 333
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
372-464 7.48e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 7.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595 372 VFDLKTMREVkRALRAHR------AYTPNDEcffifldvsrdFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFS 444
Cdd:COG2319  314 LWDLATGKLL-RTLTGHTgavrsvAFSPDGK-----------TLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFS 381

                         90       100
                 ....*....|....*....|
gi 564339595 445 PQEQeLLLTASDDATIKAWR 464
Cdd:COG2319  382 PDGR-TLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 372-463 4.73e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 4.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595 372 VFDLKTmREVKRALRAHRAYtpndeCFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQEQEl 450
Cdd:cd00200  119 VWDVET-GKCLTTLRGHTDW-----VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEK- 191

                         90
                 ....*....|...
gi 564339595 451 LLTASDDATIKAW 463
Cdd:cd00200  192 LLSSSSDGTIKLW 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-42 1.21e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.21e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564339595     7 VQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
7-42 2.87e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 2.87e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564339595    7 VQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-42 9.59e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 9.59e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 564339595   7 VQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:cd00200  170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 COG2319
WD40 repeat [General function prediction only];
6-42 1.85e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 1.85e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 564339595   6 EVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:COG2319  154 LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 COG2319
WD40 repeat [General function prediction only];
6-113 3.39e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 3.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595   6 EVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWNNDlTISLLHSADMRPYNWSYTQFSqfnqDDSLLLASGvflgph 85
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFS----PDGKLLASG------ 306

                         90       100
                 ....*....|....*....|....*...
gi 564339595  86 nSSSGEIAVISLDSFALLSRVRNKPYDV 113
Cdd:COG2319  307 -SDDGTVRLWDLATGKLLRTLTGHTGAV 333
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 428-463 5.02e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 5.02e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 564339595   428 CLAKLR-HEDVVNSVAFSPQEQeLLLTASDDATIKAW 463
Cdd:smart00320   4 LLKTLKgHTGPVTSVAFSPDGK-YLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
428-463 1.61e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 564339595  428 CLAKLR-HEDVVNSVAFSPQEQeLLLTASDDATIKAW 463
Cdd:pfam00400   3 LLKTLEgHTGSVTSLAFSPDGK-LLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
372-464 7.48e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 7.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595 372 VFDLKTMREVkRALRAHR------AYTPNDEcffifldvsrdFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFS 444
Cdd:COG2319  314 LWDLATGKLL-RTLTGHTgavrsvAFSPDGK-----------TLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFS 381

                         90       100
                 ....*....|....*....|
gi 564339595 445 PQEQeLLLTASDDATIKAWR 464
Cdd:COG2319  382 PDGR-TLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 372-463 4.73e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 4.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595 372 VFDLKTmREVKRALRAHRAYtpndeCFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQEQEl 450
Cdd:cd00200  119 VWDVET-GKCLTTLRGHTDW-----VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEK- 191

                         90
                 ....*....|...
gi 564339595 451 LLTASDDATIKAW 463
Cdd:cd00200  192 LLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
372-480 5.73e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 5.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595 372 VFDLKTMREVKRaLRAHRAYtpndecfFIFLDVSRD--FVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQEQ 448
Cdd:COG2319  230 LWDLATGKLLRT-LTGHSGS-------VRSVAFSPDgrLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGK 301

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564339595 449 eLLLTASDDATIKAW--RSPRIVRVLQAPHPRPR 480
Cdd:COG2319  302 -LLASGSDDGTVRLWdlATGKLLRTLTGHTGAVR 334
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-42 1.21e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.21e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564339595     7 VQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
372-480 2.79e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 2.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595 372 VFDLKTMREVkRALRAHR------AYTPNDEcffifldvsrdFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFS 444
Cdd:COG2319  188 LWDLATGKLL-RTLTGHTgavrsvAFSPDGK-----------LLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFS 255

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 564339595 445 PQEQeLLLTASDDATIKAWR--SPRIVRVLQAPHPRPR 480
Cdd:COG2319  256 PDGR-LLASGSADGTVRLWDlaTGELLRTLTGHSGGVN 292
WD40 COG2319
WD40 repeat [General function prediction only];
402-475 5.08e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.92  E-value: 5.08e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564339595 402 LDVSRD--FVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQEQeLLLTASDDATIKAW--RSPRIVRVLQAP 475
Cdd:COG2319  126 VAFSPDgkTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGK-LLASGSDDGTVRLWdlATGKLLRTLTGH 203
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 372-464 6.84e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 6.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595 372 VFDLKTMREVKRaLRAHraytpNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQEQeL 450
Cdd:cd00200  203 LWDLSTGKCLGT-LRGH-----ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGK-R 275

                         90
                 ....*....|....
gi 564339595 451 LLTASDDATIKAWR 464
Cdd:cd00200  276 LASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
7-42 2.87e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 2.87e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564339595    7 VQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
409-480 9.37e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.07  E-value: 9.37e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564339595 409 VASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQEQeLLLTASDDATIKAW--RSPRIVRVLQAPHPRPR 480
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGK-TLASGSADGTVRLWdlATGKLLRTLTGHSGAVT 166
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 382-472 2.65e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 2.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595 382 KRALRAHRaytpnDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQeQELLLTASDDATI 460
Cdd:cd00200    2 RRTLKGHT-----GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASAD-GTYLASGSSDKTI 75

                         90
                 ....*....|....
gi 564339595 461 KAW--RSPRIVRVL 472
Cdd:cd00200   76 RLWdlETGECVRTL 89
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 372-474 7.60e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 7.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595 372 VFDLKTMREVKRaLRAHraytpNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQeQEL 450
Cdd:cd00200  161 LWDLRTGKCVAT-LTGH-----TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPD-GYL 233

                         90       100
                 ....*....|....*....|....*.
gi 564339595 451 LLTASDDATIKAW--RSPRIVRVLQA 474
Cdd:cd00200  234 LASGSEDGTIRVWdlRTGECVQTLSG 259
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-42 9.59e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 9.59e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 564339595   7 VQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:cd00200  170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 370-474 1.40e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595 370 LLVFDLKTMrEVKRALRAHraytpNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQEQ 448
Cdd:cd00200   33 IKVWDLETG-ELLRTLKGH-----TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR 106

                         90       100
                 ....*....|....*....|....*...
gi 564339595 449 eLLLTASDDATIKAW--RSPRIVRVLQA 474
Cdd:cd00200  107 -ILSSSSRDKTIKVWdvETGKCLTTLRG 133
WD40 COG2319
WD40 repeat [General function prediction only];
6-42 1.85e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 1.85e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 564339595   6 EVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:COG2319  154 LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-42 2.06e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 2.06e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 564339595   6 EVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:cd00200  211 CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
6-113 3.39e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 3.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595   6 EVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWNNDlTISLLHSADMRPYNWSYTQFSqfnqDDSLLLASGvflgph 85
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFS----PDGKLLASG------ 306

                         90       100
                 ....*....|....*....|....*...
gi 564339595  86 nSSSGEIAVISLDSFALLSRVRNKPYDV 113
Cdd:COG2319  307 -SDDGTVRLWDLATGKLLRTLTGHTGAV 333
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-51 4.32e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 4.32e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 564339595   7 VQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWNNDlTISLLH 51
Cdd:cd00200  128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-TGKCVA 171
WD40 COG2319
WD40 repeat [General function prediction only];
6-42 6.84e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 6.84e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 564339595   6 EVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 COG2319
WD40 repeat [General function prediction only];
6-42 1.23e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 1.23e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 564339595   6 EVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:COG2319  364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-42 1.41e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 1.41e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 564339595   4 CVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:cd00200  251 GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-42 1.62e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 1.62e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 564339595   6 EVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
WD40 COG2319
WD40 repeat [General function prediction only];
6-42 3.93e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.93e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 564339595   6 EVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:COG2319  322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 428-463 5.02e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 5.02e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 564339595   428 CLAKLR-HEDVVNSVAFSPQEQeLLLTASDDATIKAW 463
Cdd:smart00320   4 LLKTLKgHTGPVTSVAFSPDGK-YLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-79 8.52e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.17  E-value: 8.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339595   3 PCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN---NDLTISLL-HSADMrpynWSytqfSQFNQDDSLLLAS 78
Cdd:cd00200   40 TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDletGECVRTLTgHTSYV----SS----VAFSPDGRILSSS 111


                 .
gi 564339595  79 G 79
Cdd:cd00200  112 S 112
WD40 COG2319
WD40 repeat [General function prediction only];
6-42 1.13e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 1.13e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 564339595   6 EVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 42
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148
WD40 pfam00400
WD domain, G-beta repeat;
428-463 1.61e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 564339595  428 CLAKLR-HEDVVNSVAFSPQEQeLLLTASDDATIKAW 463
Cdd:pfam00400   3 LLKTLEgHTGSVTSLAFSPDGK-LLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-79 2.75e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 2.75e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564339595   6 EVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN---NDLTISL-LHSADMRPYNWSytqfsqfnqDDSLLLASG 79
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDletGELLRTLkGHTGPVRDVAAS---------ADGTYLASG 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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