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Conserved domains on  [gi|564339589|ref|XP_006233687|]
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F-box/WD repeat-containing protein 5 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 7-51 2.29e-21

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 87.28  E-value: 2.29e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 564339589   7 PLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQFY 51
Cdd:cd22132    2 PLLPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKELFY 46
WD40 COG2319
WD40 repeat [General function prediction only];
450-542 8.72e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 8.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589 450 VFDLKTMREVkRALRAHR------AYTPNDEcffifldvsrdFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFS 522
Cdd:COG2319  314 LWDLATGKLL-RTLTGHTgavrsvAFSPDGK-----------TLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFS 381

                         90       100
                 ....*....|....*....|
gi 564339589 523 PQEQeLLLTASDDATIKAWR 542
Cdd:COG2319  382 PDGR-TLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-120 8.07e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 8.07e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564339589    85 VQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 super family cl43672
WD40 repeat [General function prediction only];
75-191 3.70e-06

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 3.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589  75 RLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWNNDlTISLLHSADMRPYNWSYTQFSqfnqDDSLLL 154
Cdd:COG2319  229 RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFS----PDGKLL 303

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564339589 155 ASGvflgphnSSSGEIAVISLDSFALLSRVRNKPYDV 191
Cdd:COG2319  304 ASG-------SDDGTVRLWDLATGKLLRTLTGHTGAV 333
 
Name Accession Description Interval E-value
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 7-51 2.29e-21

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 87.28  E-value: 2.29e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 564339589   7 PLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQFY 51
Cdd:cd22132    2 PLLPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKELFY 46
WD40 COG2319
WD40 repeat [General function prediction only];
450-542 8.72e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 8.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589 450 VFDLKTMREVkRALRAHR------AYTPNDEcffifldvsrdFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFS 522
Cdd:COG2319  314 LWDLATGKLL-RTLTGHTgavrsvAFSPDGK-----------TLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFS 381

                         90       100
                 ....*....|....*....|
gi 564339589 523 PQEQeLLLTASDDATIKAWR 542
Cdd:COG2319  382 PDGR-TLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 450-541 3.32e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 3.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589 450 VFDLKTmREVKRALRAHRAYtpndeCFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQEQEl 528
Cdd:cd00200  119 VWDVET-GKCLTTLRGHTDW-----VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEK- 191

                         90
                 ....*....|...
gi 564339589 529 LLTASDDATIKAW 541
Cdd:cd00200  192 LLSSSSDGTIKLW 204
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 6-50 3.42e-09

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 52.49  E-value: 3.42e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564339589    6 MPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQF 50
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-120 8.07e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 8.07e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564339589    85 VQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 65-120 3.79e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 3.79e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564339589  65 AATSWYEEFRRLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:cd00200  150 VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 pfam00400
WD domain, G-beta repeat;
85-120 2.12e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.12e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564339589   85 VQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
75-120 3.16e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 3.16e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 564339589  75 RLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:COG2319  145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 COG2319
WD40 repeat [General function prediction only];
75-191 3.70e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 3.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589  75 RLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWNNDlTISLLHSADMRPYNWSYTQFSqfnqDDSLLL 154
Cdd:COG2319  229 RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFS----PDGKLL 303

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564339589 155 ASGvflgphnSSSGEIAVISLDSFALLSRVRNKPYDV 191
Cdd:COG2319  304 ASG-------SDDGTVRLWDLATGKLLRTLTGHTGAV 333
WD40 COG2319
WD40 repeat [General function prediction only];
24-120 1.40e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589  24 ADVLAAGLVCRQWQAVSRDEFLWREQFYRYYQVARDVPRHPAATSWYEEFRRLYDMVPCVEVQTLKEHTDQVLHLSFSHS 103
Cdd:COG2319   52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD 131

                         90
                 ....*....|....*..
gi 564339589 104 GYQFASCSKDCTVKIWN 120
Cdd:COG2319  132 GKTLASGSADGTVRLWD 148
FBOX smart00256
A Receptor for Ubiquitination Targets;
9-48 1.04e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 39.73  E-value: 1.04e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564339589     9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWRE 48
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFK 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 506-541 3.45e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.45e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 564339589   506 CLAKLR-HEDVVNSVAFSPQEQeLLLTASDDATIKAW 541
Cdd:smart00320   4 LLKTLKgHTGPVTSVAFSPDGK-YLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
506-541 1.20e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 564339589  506 CLAKLR-HEDVVNSVAFSPQEQeLLLTASDDATIKAW 541
Cdd:pfam00400   3 LLKTLEgHTGSVTSLAFSPDGK-LLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 7-51 2.29e-21

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 87.28  E-value: 2.29e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 564339589   7 PLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQFY 51
Cdd:cd22132    2 PLLPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKELFY 46
WD40 COG2319
WD40 repeat [General function prediction only];
450-542 8.72e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 8.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589 450 VFDLKTMREVkRALRAHR------AYTPNDEcffifldvsrdFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFS 522
Cdd:COG2319  314 LWDLATGKLL-RTLTGHTgavrsvAFSPDGK-----------TLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFS 381

                         90       100
                 ....*....|....*....|
gi 564339589 523 PQEQeLLLTASDDATIKAWR 542
Cdd:COG2319  382 PDGR-TLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 450-541 3.32e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 3.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589 450 VFDLKTmREVKRALRAHRAYtpndeCFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQEQEl 528
Cdd:cd00200  119 VWDVET-GKCLTTLRGHTDW-----VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEK- 191

                         90
                 ....*....|...
gi 564339589 529 LLTASDDATIKAW 541
Cdd:cd00200  192 LLSSSSDGTIKLW 204
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 6-50 3.42e-09

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 52.49  E-value: 3.42e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564339589    6 MPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQF 50
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
WD40 COG2319
WD40 repeat [General function prediction only];
450-558 6.94e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 6.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589 450 VFDLKTMREVKRaLRAHRAYtpndecfFIFLDVSRD--FVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQEQ 526
Cdd:COG2319  230 LWDLATGKLLRT-LTGHSGS-------VRSVAFSPDgrLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGK 301

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564339589 527 eLLLTASDDATIKAW--RSPRIVRVLQAPHPRPR 558
Cdd:COG2319  302 -LLASGSDDGTVRLWdlATGKLLRTLTGHTGAVR 334
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-120 8.07e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 8.07e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564339589    85 VQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
450-558 3.30e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 3.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589 450 VFDLKTMREVkRALRAHR------AYTPNDEcffifldvsrdFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFS 522
Cdd:COG2319  188 LWDLATGKLL-RTLTGHTgavrsvAFSPDGK-----------LLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFS 255

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 564339589 523 PQEQeLLLTASDDATIKAWR--SPRIVRVLQAPHPRPR 558
Cdd:COG2319  256 PDGR-LLASGSADGTVRLWDlaTGELLRTLTGHSGGVN 292
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 65-120 3.79e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 3.79e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564339589  65 AATSWYEEFRRLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:cd00200  150 VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 450-542 4.71e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 4.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589 450 VFDLKTMREVKRaLRAHraytpNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQEQeL 528
Cdd:cd00200  203 LWDLSTGKCLGT-LRGH-----ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGK-R 275

                         90
                 ....*....|....
gi 564339589 529 LLTASDDATIKAWR 542
Cdd:cd00200  276 LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
480-553 6.10e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.92  E-value: 6.10e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564339589 480 LDVSRD--FVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQEQeLLLTASDDATIKAW--RSPRIVRVLQAP 553
Cdd:COG2319  126 VAFSPDgkTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGK-LLASGSDDGTVRLWdlATGKLLRTLTGH 203
WD40 pfam00400
WD domain, G-beta repeat;
85-120 2.12e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.12e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564339589   85 VQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
487-558 1.10e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.07  E-value: 1.10e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564339589 487 VASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQEQeLLLTASDDATIKAW--RSPRIVRVLQAPHPRPR 558
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGK-TLASGSADGTVRLWdlATGKLLRTLTGHSGAVT 166
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-129 1.37e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 1.37e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564339589  75 RLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWNNDlTISLLH 129
Cdd:cd00200  118 KVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-TGKCVA 171
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-120 1.62e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 1.62e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 564339589  75 RLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:cd00200  202 KLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-120 1.91e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 1.91e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 564339589  75 RLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:cd00200  244 RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 460-550 1.91e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 1.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589 460 KRALRAHRaytpnDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQeQELLLTASDDATI 538
Cdd:cd00200    2 RRTLKGHT-----GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASAD-GTYLASGSSDKTI 75

                         90
                 ....*....|....
gi 564339589 539 KAW--RSPRIVRVL 550
Cdd:cd00200   76 RLWdlETGECVRTL 89
WD40 COG2319
WD40 repeat [General function prediction only];
75-120 3.16e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 3.16e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 564339589  75 RLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:COG2319  145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 8-48 3.53e-06

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 43.85  E-value: 3.53e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 564339589   8 LLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWRE 48
Cdd:cd22151    2 KLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWEN 42
WD40 COG2319
WD40 repeat [General function prediction only];
75-191 3.70e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 3.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589  75 RLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWNNDlTISLLHSADMRPYNWSYTQFSqfnqDDSLLL 154
Cdd:COG2319  229 RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFS----PDGKLL 303

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564339589 155 ASGvflgphnSSSGEIAVISLDSFALLSRVRNKPYDV 191
Cdd:COG2319  304 ASG-------SDDGTVRLWDLATGKLLRTLTGHTGAV 333
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 450-552 5.41e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 5.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589 450 VFDLKTMREVKRaLRAHraytpNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQeQEL 528
Cdd:cd00200  161 LWDLRTGKCVAT-LTGH-----TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPD-GYL 233

                         90       100
                 ....*....|....*....|....*.
gi 564339589 529 LLTASDDATIKAW--RSPRIVRVLQA 552
Cdd:cd00200  234 LASGSEDGTIRVWdlRTGECVQTLSG 259
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 448-552 1.03e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589 448 LLVFDLKTMrEVKRALRAHraytpNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLR-HEDVVNSVAFSPQEQ 526
Cdd:cd00200   33 IKVWDLETG-ELLRTLKGH-----TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR 106

                         90       100
                 ....*....|....*....|....*...
gi 564339589 527 eLLLTASDDATIKAW--RSPRIVRVLQA 552
Cdd:cd00200  107 -ILSSSSRDKTIKVWdvETGKCLTTLRG 133
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-157 1.39e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589  75 RLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN---NDLTISLL-HSADMrpynWSytqfSQFNQDD 150
Cdd:cd00200   34 KVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDletGECVRTLTgHTSYV----SS----VAFSPDG 105


                 ....*..
gi 564339589 151 SLLLASG 157
Cdd:cd00200  106 RILSSSS 112
WD40 COG2319
WD40 repeat [General function prediction only];
24-120 1.40e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339589  24 ADVLAAGLVCRQWQAVSRDEFLWREQFYRYYQVARDVPRHPAATSWYEEFRRLYDMVPCVEVQTLKEHTDQVLHLSFSHS 103
Cdd:COG2319   52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD 131

                         90
                 ....*....|....*..
gi 564339589 104 GYQFASCSKDCTVKIWN 120
Cdd:COG2319  132 GKTLASGSADGTVRLWD 148
WD40 COG2319
WD40 repeat [General function prediction only];
75-120 1.45e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 1.45e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 564339589  75 RLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:COG2319  355 RLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
75-120 1.59e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 1.59e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 564339589  75 RLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:COG2319  187 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-120 2.06e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 2.06e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 564339589  75 RLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:cd00200   76 RLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
F-box_AtSKIP19-like cd22164
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ...
 9-47 6.25e-05

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438935 [Multi-domain]  Cd Length: 47  Bit Score: 40.66  E-value: 6.25e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 564339589   9 LPDSLVYQIFLSLGPADVLA-AGLVCRQWQAVSRDEFLWR 47
Cdd:cd22164    5 LPDDLTASILSRLGAIDILTnAQKVCKLWRRICKDPSMWR 44
WD40 COG2319
WD40 repeat [General function prediction only];
75-120 6.39e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 6.39e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 564339589  75 RLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN 120
Cdd:COG2319  313 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 6-47 6.58e-05

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 40.30  E-value: 6.58e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 564339589   6 MPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:cd22139    1 WLCLPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWK 42
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
 8-48 8.16e-05

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 39.96  E-value: 8.16e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 564339589   8 LLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWRE 48
Cdd:cd22148    4 LLPEHLALKILSYLSPKELLIASQVSKTWRRLASSNELWKA 44
FBOX smart00256
A Receptor for Ubiquitination Targets;
9-48 1.04e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 39.73  E-value: 1.04e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564339589     9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWRE 48
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFK 40
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 9-41 1.32e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 39.35  E-value: 1.32e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 564339589   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSR 41
Cdd:cd09917    3 LPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 9-47 1.71e-04

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 39.26  E-value: 1.71e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 564339589   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:cd22123    4 LPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLWR 42
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
 7-48 1.74e-04

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 39.23  E-value: 1.74e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 564339589   7 PLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWRE 48
Cdd:cd22109    4 SLRRRDALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQR 45
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
 9-46 2.04e-04

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 38.93  E-value: 2.04e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564339589   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLW 46
Cdd:cd22114    4 LPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDESLW 41
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
 9-47 2.18e-04

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 38.90  E-value: 2.18e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 564339589   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:cd22137    3 LPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWR 41
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 506-541 3.45e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.45e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 564339589   506 CLAKLR-HEDVVNSVAFSPQEQeLLLTASDDATIKAW 541
Cdd:smart00320   4 LLKTLKgHTGPVTSVAFSPDGK-YLASGSDDGTIKLW 39
F-box_AtARP8-like cd22156
F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar ...
 9-46 4.20e-04

F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar proteins; AtARP8, also called F-box protein ARP8, is an F-box protein localized to the nucleolus in Arabidopsis. Unlike other plant nuclear actin-related proteins (ARPs), ARP8 is unique in having an F-box domain and an actin homology domain. It may play a role in nucleolar functions. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438927  Cd Length: 45  Bit Score: 38.13  E-value: 4.20e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564339589   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLW 46
Cdd:cd22156    5 LPEDVLMQILRLLGPKDAAKLCLVCKSWRYLVSDNRLW 42
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 9-47 4.33e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.90  E-value: 4.33e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564339589    9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:pfam00646   4 LPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
F-box_FBXL13 cd22124
F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also ...
 8-46 6.17e-04

F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438896  Cd Length: 42  Bit Score: 37.70  E-value: 6.17e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 564339589   8 LLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLW 46
Cdd:cd22124    3 LLPRKAALKIFSYLDLRDLARCAQVCRSWKVITQSSSLW 41
WD40 pfam00400
WD domain, G-beta repeat;
506-541 1.20e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 564339589  506 CLAKLR-HEDVVNSVAFSPQEQeLLLTASDDATIKAW 541
Cdd:pfam00400   3 LLKTLEgHTGSVTSLAFSPDGK-LLASGSDDGTVKVW 38
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
 9-48 1.51e-03

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438876  Cd Length: 48  Bit Score: 36.85  E-value: 1.51e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 564339589   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWRE 48
Cdd:cd22104    4 LPSVVLVHIFSYLPPRDRLRASSTCRRWREALFHPSLWRS 43
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 9-46 1.85e-03

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 36.16  E-value: 1.85e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564339589   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLW 46
Cdd:cd22118    4 LPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
 9-47 1.96e-03

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 36.20  E-value: 1.96e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 564339589   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:cd22149    4 LSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWR 42
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 6-50 2.01e-03

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 36.14  E-value: 2.01e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 564339589   6 MPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQF 50
Cdd:cd22147    2 LSALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-157 2.15e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 2.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564339589  84 EVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN---NDLTISL-LHSADMRPYNWSytqfsqfnqDDSLLLASG 157
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDletGELLRTLkGHTGPVRDVAAS---------ADGTYLASG 69
F-box_FBXW8 cd22134
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ...
 9-46 3.90e-03

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438906  Cd Length: 48  Bit Score: 35.43  E-value: 3.90e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564339589   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLW 46
Cdd:cd22134    7 LPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLW 44
F-box_AtSKIP3-like cd22162
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar ...
 6-51 4.13e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar proteins; AtSKIP3, also called F-box protein SKIP3, F-box protein PP2-B9, or protein PHLOEM PROTEIN 2-LIKE B9, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. This subfamily also includes many other Arabidopsis thaliana protein PHLOEM PROTEIN 2-LIKE proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438933  Cd Length: 46  Bit Score: 35.25  E-value: 4.13e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 564339589   6 MPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWrEQFY 51
Cdd:cd22162    1 LEDLPEDCIALILSFTSPRDVCRLSAVSKTFRSAAESDVVW-ERFL 45
F-box_FBXO4 cd22085
F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called ...
 9-47 4.33e-03

F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438857  Cd Length: 50  Bit Score: 35.46  E-value: 4.33e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 564339589   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:cd22085    6 LPIDLQLYILSFLSPHDLCQLGLTSHYWHTLVRDPLLWR 44
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
 8-47 6.32e-03

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 35.48  E-value: 6.32e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 564339589   8 LLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:cd22133   20 LLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59
F-box_AtTIR1-like cd22159
F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), ...
 6-41 6.92e-03

F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), coronatine-insensitive protein 1 (COI1) and similar proteins; TIR1, also called F-box/LRR-repeat protein 1 (FBL1), is part of an SCF (SKP1-cullin-F-box) protein ligase complex that promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1 is an auxin receptor that plays a potential role in plant hormone signaling. COI1, also called F-box/LRR-repeat protein 2 (FBL2), is the substrate-recruiting module of an SCF ubiquitin E3 ligase complex. It mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JASMONATE ZIM-domain (JAZ) family proteins. This subfamily also includes Arabidopsis thaliana EIN3-binding F-box protein 1 (EBF1). EBF1, also called F-box/LRR-repeat protein 6 (FBL6), is a component of the SCF(EBF1) E3 ubiquitin ligase complex, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438930  Cd Length: 40  Bit Score: 34.75  E-value: 6.92e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 564339589   6 MPLLPDSLVYQIFLSLG-PADVLAAGLVCRQWQAVSR 41
Cdd:cd22159    1 IDLLPDEILELIFSYLSdPWDRNSCSLVCKRWYRLER 37
F-box_FBXO13 cd22092
F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called ...
 8-48 9.81e-03

F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called FBX13, F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438864  Cd Length: 49  Bit Score: 34.32  E-value: 9.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 564339589   8 LLPDSLVYQIFLSLGPAD-VLAAGLVCRQWQAVSRDEFLWRE 48
Cdd:cd22092    4 QLPDSILLKIFSYLSLQErCLSASLVCKYWRDLCLDSQFWKQ 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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