F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564336987 146 QVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22133    1 QVRHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 256 KVLKGHDDhVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQmrDNIIISGSTDRTLKVWN 329
Cdd:cd00200    3 RTLKGHTG-GVTCVAFspDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVrdvaASAD--GTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 330 AETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMV 405
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 406 KVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ-SLTSGMELKDN-ILVSGNA 481
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGyLLASGSE 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564336987 482 DSTVKIWDIKTGQCLQTLQGpskHQSAVTCLQF--NKNFVITSSDDGTVKLWD 532
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSG---HTNSVTSLAWspDGKRLASGSADGTIRIWD 289

F-box-like; This is an F-box-like family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564336987  163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 564336987   492 TGQCLQTLQGpskHQSAVTCLQFNKN--FVITSSDDGTVKLWD 532
Cdd:smart00320   1 SGELLKTLKG---HTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40

A Receptor for Ubiquitination Targets;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 564336987   166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREK 206
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41

WD40 repeat [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 247 WRRGELRSPKVLKGHDDHViTCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTD 322
Cdd:COG2319  105 WDLATGLLLRTLTGHTGAV-RSVAFspDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDD 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 323 RTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVS 398
Cdd:COG2319  184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 399 GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDN 474
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGK 343

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564336987 475 ILVSGNADSTVKIWDIKTGQCLQTLQGpskHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKT 535
Cdd:COG2319  344 TLASGSDDGTVRLWDLATGELLRTLTG---HTGAVTSVAFSPDgrTLASGSADGTVRLWDLAT 403

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 335 CIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 410
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 411 ETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSltSGMELK----DNILVSGNADST 484
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTD--WVNSVAfspdGTFVASSSQDGT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 485 VKIWDIKTGQCLQTLQGpskHQSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNLVtlesgGSGGVVWRIRASNT 562
Cdd:cd00200  159 IKLWDLRTGKCVATLTG---HTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-----GHENGVNSVAFSPD 230

                        250
                 ....*....|..
gi 564336987 563 KLVCAVGSRNGT 574
Cdd:cd00200  231 GYLLASGSEDGT 242

WD40 repeat [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 392 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGM 469
Cdd:COG2319    5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAAspDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 470 ELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGpskHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNLVtl 545
Cdd:COG2319   85 AFSpdGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSVAFSPDgkTLASGSADGTVRLWDLATGKLLRTLT-- 159

                        170       180       190
                 ....*....|....*....|....*....|
gi 564336987 546 esgGSGGVVWRIRAS-NTKLVcAVGSRNGT 574
Cdd:COG2319  160 ---GHSGAVTSVAFSpDGKLL-ASGSDDGT 185

F-box-like; This is an F-box-like family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564336987  163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564336987 161 DFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEG 211
Cdd:cd22173    1 DFTTVLPRFLSLYIFSFLDPRSLCRAAQVSWHWKFLAEQDCLWMPKCVKFG 51

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 564336987 158 FQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22172    1 EHIDFTRVLPRVLSLYIFSFLDPRSLCRCAQVCWYWKYLTELDQLWMPKC 50

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 564336987 164 SLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWRE 205
Cdd:cd22132    2 PLLPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKE 43

protein SPA1-RELATED; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 274 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS---SQMRDNIIISGSTDRTLKVWNAETGECIHTLyGHTSTVRCMH 350
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSidySSADPTLLASGSDDGSVKLWSINQGVSIGTI-KTKANICCVQ 624

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 351 LHE---KRVVSGSRDATLRVWDIETGQC-LHVLMGHVAAVRCVQY-DGRRVVSGAYDFMVKVWDPE------TETCLHTL 419
Cdd:PLN00181 625 FPSesgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSF 704

                        170       180
                 ....*....|....*....|....
gi 564336987 420 QGHTNrvySLQFDGIHVVSGSLDT 443
Cdd:PLN00181 705 MGHTN---VKNFVGLSVSDGYIAT 725

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 564336987 165 LLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22139    3 CLPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWKQIC 45

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 564336987 163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDN-LLWREKC 207
Cdd:cd22113    1 IELLPPEMSLRIFSQLDVQSLCRASQTCKTWNDLIENSdYLWRPHC 46

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 564336987 164 SLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAE 198
Cdd:cd09917    1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 564336987 165 LLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22087    3 ALPPEIKLRILSLLDVRSLLSLSQVCRDLNSATNDQLLWRFLL 45

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 564336987   492 TGQCLQTLQGpskHQSAVTCLQFNKN--FVITSSDDGTVKLWD 532
Cdd:smart00320   1 SGELLKTLKG---HTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 564336987 163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLW 203
Cdd:cd22118    1 ISSLPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564336987  163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 564336987 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22115    7 LPKELLLRIFSFLDVVTLCRCAQVSKYWNVLALDGSNWQ 45

WD domain, G-beta repeat;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564336987  493 GQCLQTLQGpskHQSAVTCLQFNKN--FVITSSDDGTVKLWD 532
Cdd:pfam00400   1 GKLLKTLEG---HTGSVTSLAFSPDgkLLASGSDDGTVKVWD 39

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar proteins; AtSKIP31, also called F-box protein SKIP31, is a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 564336987 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22166    4 LPPELFRHILKFLSPEDLTSCATVCRFLRGAASDESLWR 42

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 564336987 163 ISLLPKELALY-VLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22109    2 LESLRRRDALFcVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 564336987 164 SLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLW 203
Cdd:cd22114    2 DSLPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDESLW 41

A Receptor for Ubiquitination Targets;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 564336987   166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREK 206
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41

F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564336987 159 QRDFISLLPKE----LALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWRE 205
Cdd:cd22183    1 QRDFITALPAKgldhIAENILSYLDAESLCAAELVCKEWQRVISEGMLWKK 51

coronin; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 381 GHVAAVRCVQYDGRRVVSGAYDFMVKVWD-PE---TETCLHT---LQGHTNRVYSLQF----DGIhVVSGSLDTSIRVWD 449
Cdd:PTZ00421  76 GPIIDVAFNPFDPQKLFTASEDGTIMGWGiPEeglTQNISDPivhLQGHTKKVGIVSFhpsaMNV-LASAGADMVVNVWD 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564336987 450 VETGNCIHTLTGHQSLTSGME--LKDNILVSGNADSTVKIWDIKTGQCLQTLQG--PSKHQSAVTCLQfnKNFVIT---- 521
Cdd:PTZ00421 155 VERGKAVEVIKCHSDQITSLEwnLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAhaSAKSQRCLWAKR--KDLIITlgcs 232

                        170
                 ....*....|...
gi 564336987 522 SSDDGTVKLWDLK 534
Cdd:PTZ00421 233 KSQQRQIMLWDTR 245

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 564336987 164 SLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22151    1 RKLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENAC 44

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 564336987 163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCK 208
Cdd:cd22093    1 IERLPSEILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKLYS 46

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar proteins; AtSKIP22, also called F-box protein SKIP22, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 564336987 165 LLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22165    4 RLPTELKLKILELLPGVDLARMACVCSELRFLASNDDLWKQKF 46

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 564336987 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22091    4 LPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWK 42