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Conserved domains on  [gi|1958647902|ref|XP_006231112|]
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lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X3 [Rattus norvegicus]

Protein Classification

cytochrome b family protein( domain architecture ID 581032)

cytochrome b family protein such as formate dehydrogenase subunit gamma or cytochrome b, a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

Gene Ontology:  GO:0046872|GO:0016491

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cytochrome_b_N super family cl23723
Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit ...
 10-188 4.44e-90

Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, cytochrome b6 is analogous to eukaryote cytochrome b, containing two chains: helices A-D are encoded by the petB gene and helices E-H are encoded by the petD gene in these organisms. Cytochrome b/b6 contains two bound hemes and two ubiquinol/ubiquinone binding sites. The C-terminal portion of cytochrome b is described in a separate CD.


The actual alignment was detected with superfamily member cd08762:

Pssm-ID: 474033  Cd Length: 179  Bit Score: 264.04  E-value: 4.44e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  10 CMVLGSLGSMCILFTTYWMQYWRGGFAWDGTVLMFNWHPVLMVSGMVVLYGAASLVYRLPASWVGPKLPWKVLHAALHLL 89
Cdd:cd08762     1 CLLLGILGIACVVLVVHWNQMWRGGFAWDGSSKNFNWHPVLMVTGMVVLYGNAALVYRIPLTWGGPKLPWKLLHAGLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  90 AFTVTVVGLTAVFGFHNHSKITHLYSLHSWLGITTVALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIA 169
Cdd:cd08762    81 AFILTVIGLCAVFNFHNVHHTANLYSLHSWVGICTVALFTCQWVMGFTSFLLPWAPMWLRALVKPIHVFFGAMILVLSIA 160

                         170
                  ....*....|....*....
gi 1958647902 170 SVISGINEKLFFVLKNATR 188
Cdd:cd08762   161 SCISGINEKLFFSLKNTTN 179
 
Name Accession Description Interval E-value
Cyt_b561_CYBASC3 cd08762
Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as ...
 10-188 4.44e-90

Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176492  Cd Length: 179  Bit Score: 264.04  E-value: 4.44e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  10 CMVLGSLGSMCILFTTYWMQYWRGGFAWDGTVLMFNWHPVLMVSGMVVLYGAASLVYRLPASWVGPKLPWKVLHAALHLL 89
Cdd:cd08762     1 CLLLGILGIACVVLVVHWNQMWRGGFAWDGSSKNFNWHPVLMVTGMVVLYGNAALVYRIPLTWGGPKLPWKLLHAGLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  90 AFTVTVVGLTAVFGFHNHSKITHLYSLHSWLGITTVALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIA 169
Cdd:cd08762    81 AFILTVIGLCAVFNFHNVHHTANLYSLHSWVGICTVALFTCQWVMGFTSFLLPWAPMWLRALVKPIHVFFGAMILVLSIA 160

                         170
                  ....*....|....*....
gi 1958647902 170 SVISGINEKLFFVLKNATR 188
Cdd:cd08762   161 SCISGINEKLFFSLKNTTN 179
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 46-181 9.28e-47

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 152.38  E-value: 9.28e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  46 WHPVLMVSGMVVLYGAASLVYRLPASWVGPKLPWKVLHAALHLLAFTVTVVGLTAVFGFHNHSKITHLYSLHSWLGITTV 125
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958647902 126 ALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIASVISGINEKLFF 181
Cdd:pfam03188  81 ILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIF 136
PLN02680 PLN02680
carbon-monoxide oxygenase
 11-215 5.20e-38

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 133.00  E-value: 5.20e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  11 MVLGSLGSMCILFTTYWMQYWRGGFAW--DGTVLMFNWHPVLMVSGMVVLYGAASLVYRlpaSWVGPKLPWKVLHAALHL 88
Cdd:PLN02680   12 MLVRLLGVIVAALVLTWTVHYRGGLALssDNKDLIFNVHPVLMVIGLVLLNGEAMLAYK---TVPGTKNLKKLVHLTLQF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  89 LAFTVTVVGLTAVFGFHNHSKITHLYSLHSWLGITTVALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSI 168
Cdd:PLN02680   89 LAFCLSLIGVWAALKFHNEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWHVFFGIYIYALAV 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958647902 169 ASVISGINEKLFFV-LKNATRPYSSlpgEAVFANSTGILVVSFGLLVL 215
Cdd:PLN02680  169 ATATTGILEKATFLqSNKVISRYST---EAMLVNSLGILIVVLGGFVI 213
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 46-175 4.72e-31

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 111.55  E-value: 4.72e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902   46 WHPVLMVSGMVVLYGAASLVYRLPASWVGPKLpWKVLHAALHLLAFTVTVVGLTAVFGFHNHSKITHLYSLHSWLGITTV 125
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARPLTRFLSKPT-WFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAF 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958647902  126 ALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIASVISGI 175
Cdd:smart00665  80 VLAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
 
Name Accession Description Interval E-value
Cyt_b561_CYBASC3 cd08762
Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as ...
 10-188 4.44e-90

Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176492  Cd Length: 179  Bit Score: 264.04  E-value: 4.44e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  10 CMVLGSLGSMCILFTTYWMQYWRGGFAWDGTVLMFNWHPVLMVSGMVVLYGAASLVYRLPASWVGPKLPWKVLHAALHLL 89
Cdd:cd08762     1 CLLLGILGIACVVLVVHWNQMWRGGFAWDGSSKNFNWHPVLMVTGMVVLYGNAALVYRIPLTWGGPKLPWKLLHAGLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  90 AFTVTVVGLTAVFGFHNHSKITHLYSLHSWLGITTVALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIA 169
Cdd:cd08762    81 AFILTVIGLCAVFNFHNVHHTANLYSLHSWVGICTVALFTCQWVMGFTSFLLPWAPMWLRALVKPIHVFFGAMILVLSIA 160

                         170
                  ....*....|....*....
gi 1958647902 170 SVISGINEKLFFVLKNATR 188
Cdd:cd08762   161 SCISGINEKLFFSLKNTTN 179
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 21-239 6.48e-69

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 211.42  E-value: 6.48e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  21 ILFTTYWMQYWRGGFAWDGTVLMFNWHPVLMVSGMVVLYGAASLVYRLPASWVgpKLPWKVLHAALHLLAFTVTVVGLTA 100
Cdd:cd08764     1 VVLVGIWLGKFRGGFSWTGPGLQFNWHPLLMVLGLIFLYGNSILVYRVFRNTR--KKRLKLLHAVLHLLAFILAVIGLKA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902 101 VFGFHNHSK--ITHLYSLHSWLGITTVALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIASVISGINEK 178
Cdd:cd08764    79 VFDSHNLAKppIPNMYSLHSWLGLTAVILFSLQWVGGFVSFLFPGLPETLRAAYLPLHVFFGLFIFVLAVATALLGITEK 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958647902 179 LFFVLKNatrpYSSLPGEAVFANSTGILVVSFGLLVLYILLASSWRRPDPGalTDRQLLLQ 239
Cdd:cd08764   159 AFFSLNK----YSNLPAEGVLGNFIGIVLVIFGGLVVYLVTEPDYKRIELP--EEEELLIQ 213
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 46-181 9.28e-47

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 152.38  E-value: 9.28e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  46 WHPVLMVSGMVVLYGAASLVYRLPASWVGPKLPWKVLHAALHLLAFTVTVVGLTAVFGFHNHSKITHLYSLHSWLGITTV 125
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958647902 126 ALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIASVISGINEKLFF 181
Cdd:pfam03188  81 ILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIF 136
Cyt_b561_CYBRD1 cd08765
Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate ...
 34-185 1.24e-43

Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176495  Cd Length: 153  Bit Score: 145.04  E-value: 1.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  34 GFAWDGTVLMFNWHPVLMVSGMVVLYGAASLVYRLPASWVGPKLPWKVLHAALHLLAFTVTVVGLTAVFGFHNHSKITHL 113
Cdd:cd08765     2 GLGWDGGAAEFNWHPVLMVIGFIFIQGIAIIVYRLPWTWKCSKLLMKLIHAGLHILAFILAIISVVAVFVFHNAKNIPNM 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958647902 114 YSLHSWLGITTVALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIASVISGINEKLFFVLKN 185
Cdd:cd08765    82 YSLHSWVGLAAVILYPLQLVLGISVYLLPVAPVRLRAALMPLHVYSGLFIFGTVIATALMGITEKLIFSLKS 153
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 43-175 9.85e-39

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 131.64  E-value: 9.85e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  43 MFNWHPVLMVSGMVVLYGAASLVYRLPasWVGPKLPWKVLHAALHLLAFTVTVVGLTAVFGFHNHSKITHLYSLHSWLGI 122
Cdd:cd08554     1 EFNWHPLLMVIGFVFLMGEALLVYRVF--RLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958647902 123 TTVALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIASVISGI 175
Cdd:cd08554    79 ATVLLFLLQFLSGFVLFLLPLLRLSYRSSLLPFHRFFGLAIFVLAIATILLGI 131
PLN02680 PLN02680
carbon-monoxide oxygenase
 11-215 5.20e-38

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 133.00  E-value: 5.20e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  11 MVLGSLGSMCILFTTYWMQYWRGGFAW--DGTVLMFNWHPVLMVSGMVVLYGAASLVYRlpaSWVGPKLPWKVLHAALHL 88
Cdd:PLN02680   12 MLVRLLGVIVAALVLTWTVHYRGGLALssDNKDLIFNVHPVLMVIGLVLLNGEAMLAYK---TVPGTKNLKKLVHLTLQF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  89 LAFTVTVVGLTAVFGFHNHSKITHLYSLHSWLGITTVALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSI 168
Cdd:PLN02680   89 LAFCLSLIGVWAALKFHNEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWHVFFGIYIYALAV 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958647902 169 ASVISGINEKLFFV-LKNATRPYSSlpgEAVFANSTGILVVSFGLLVL 215
Cdd:PLN02680  169 ATATTGILEKATFLqSNKVISRYST---EAMLVNSLGILIVVLGGFVI 213
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 37-181 5.61e-37

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176493  Cd Length: 143  Bit Score: 127.62  E-value: 5.61e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  37 WDGTvLMFNWHPVLMVSGMVVLYGAASLVYRLPASwvGPKLPWKVLHAALHLLAFTVTVVGLTAVFGFHNHSKITHLYSL 116
Cdd:cd08763     1 WSGP-LQFNVHPLCMVLGLVFLCGEALLVYRVFRN--ETKRSTKILHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958647902 117 HSWLGITTVALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIASVISGINEKLFF 181
Cdd:cd08763    78 HSWCGILTFVLYFLQWLIGFSFFLFPGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGLTEKLLF 142
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 42-181 2.07e-34

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 120.87  E-value: 2.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  42 LMFNWHPVLMVSGMVVLYGAASLVYR-LPASwvgpKLPWKVLHAALHLLAFTVTVVGLTAVFGFHNHSKITHLYSLHSWL 120
Cdd:cd08766     6 LIFNVHPVLMVIGFIFLAGEAILAYKtVPGS----REVQKAVHLTLHLVALVLGIVGIYAAFKFHNEVGIPNLYSLHSWL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958647902 121 GITTVALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIASVISGINEKLFF 181
Cdd:cd08766    82 GIGTISLFGLQWLFGFVTFWFPGASRNTRAALLPWHVFLGLAIYYLAIATAETGLLEKLTF 142
PLN02810 PLN02810
carbon-monoxide oxygenase
 27-222 2.75e-33

carbon-monoxide oxygenase


Pssm-ID: 178406  Cd Length: 231  Bit Score: 120.70  E-value: 2.75e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  27 WMQYWRGGFAWDGT--VLMFNWHPVLMVSGMVVLYGAASLVYR-LPASwvgpKLPWKVLHAALHLLAFTVTVVGLTAVFG 103
Cdd:PLN02810   28 WSIYYRGGLAWEATnkNLIFNLHPVLMLIGLIIIGGEAIMSYKsLPLK----KEVKKLIHLVLHAIALILGIFGICAAFK 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902 104 FHNHSKITHLYSLHSWLGITTVALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIASVISGINEKLFFVL 183
Cdd:PLN02810  104 NHNESGIANLYSLHSWLGIGIISLYGIQWIYGFIVFFFPGGSTNLRSGSLPWHVLFGLFVYILAVGNAALGFLEKLTFLE 183

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1958647902 184 KNATRPYSSlpgEAVFANSTGILVVSFGLLVLYILLASS 222
Cdd:PLN02810  184 SGGLDKYGS---EALLVNFTAIITILYGAFVVLTALAQS 219
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 46-175 4.72e-31

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 111.55  E-value: 4.72e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902   46 WHPVLMVSGMVVLYGAASLVYRLPASWVGPKLpWKVLHAALHLLAFTVTVVGLTAVFGFHNHSKITHLYSLHSWLGITTV 125
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARPLTRFLSKPT-WFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAF 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958647902  126 ALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIASVISGI 175
Cdd:smart00665  80 VLAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
PLN02351 PLN02351
cytochromes b561 family protein
 47-221 9.23e-14

cytochromes b561 family protein


Pssm-ID: 215201  Cd Length: 242  Bit Score: 68.78  E-value: 9.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  47 HPVLMVSGMVVLYGAASLVYR-LPaswvGPKLPWKVLHAALHLLAFTVTVVGLTAVFgFHNHSKITHLYSLHSWLGITTV 125
Cdd:PLN02351   54 HPLLMVIGFILISGEAILVHRwLP----GSRKTKKSVHLWLQGLALASGVFGIWTKF-HGQDGIVANFYSLHSWMGLICV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902 126 ALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIASVISGINEKLFFVLKNatRPYSSLPGEAVFANSTGi 205
Cdd:PLN02351  129 SLFGAQWLTGFMSFWHRGEMRTTRTTVLPWHVFLGLYTYGLAVATAETGLLEKLTFLQTK--RNVSKHGSESMVVNGLG- 205

                         170
                  ....*....|....*.
gi 1958647902 206 lvVSFGLLVLYILLAS 221
Cdd:PLN02351  206 --LGLALLSGIVILAA 219
Cyt_b561_FRRS1_like cd08760
Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in ...
 42-175 6.85e-10

Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176490  Cd Length: 191  Bit Score: 56.97  E-value: 6.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  42 LMFNWHPVLMVSGMVVLYGAASLVYRLpaSWVGPKLpWKVLHAALHLLAFTVTVVGltAVFGF-HNHSKITHLYSLHSWL 120
Cdd:cd08760    34 TLIKAHGVLMAIAWGILMPIGALLARY--FLLGDPV-WFYLHAGLQLLAVLLAIAG--FVLGIvLVQGGGGSLNNAHAIL 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958647902 121 GITTVALFACQWFLGfavFLLPWASQWLRSLLKPVHVFFGACILSLSIASVISGI 175
Cdd:cd08760   109 GIIVLALAILQPLLG---LLRPHPGSKKRSIWNWAHRWLGRAALILAIVNIFLGL 160
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 44-180 8.58e-10

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 56.53  E-value: 8.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902  44 FNWHPVLMVSGMVVLYGAASLVYRLPASWVGPKLPWKV-LHAALHLLAFTVTVVGLTAVFGFHNHSKITHLYSLHSWLGI 122
Cdd:cd08761    21 FSWHPLLMSLGFLLLMTEALLLLQPTSSLTKLARKTKVrLHWILQLLALLCILAGLVAIYYNKERNGKPHFTSWHGILGL 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647902 123 TTVALFACQWFLGFAVFLLPWASQWLRSL--LKPVHVFFGACILSLSIASVISGINEKLF 180
Cdd:cd08761   101 VTVILIVLQALGGLALLYPPGLRRGESKAkkLKKYHRLSGYVAYLLGLATLVLGLETRWF 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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