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Conserved domains on  [gi|564332772|ref|XP_006231062|]
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WD repeat-containing protein 74 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 17-286 2.03e-92

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


:

Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 278.73  E-value: 2.03e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772  17 TGILKGVNLQRK--LAANFTP--SGQPRREEAVNALCWGT-GGETQILVGCADRTVRHFNAEEG----TFQ--SQRYCPG 85
Cdd:cd22857    1 LGLVKVVEARGKqeEAAPKVVdrWGGPDKSKAVQALSIADrESEPLLAVARKNGTVEVLDPENGdllaSFSdsEPATKLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772  86 GEGTFRGLAqADDGTLITCVDSGILRVW-CENDKEASSDPL----------------------------------LELK- 129
Cdd:cd22857   81 EEDHFVGLH-LFSGTLLTCTSKGSLRSTkLPDDSTASSSPTawvclggnllcmrvdpnenyfafggkevelnvwdLEEKp 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 130 --------VRNDWLDLRVPIWDQDIQFLPGSQ--KLVTCTGYHQVRIYDPASpQRRPVLEATYGEYPLTAMTLTPEGNSV 199
Cdd:cd22857  160 gkiwraknVPNDSLGLRVPVWVTDLTFLSKDDhrKIVTGTGYHQVRLYDTRA-QRRPVVSVDFGETPIKAVAEDPDGHTV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 200 IVGNTHGQLAEIDFRQGRLLGCLKGLAG-SVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRgLEHKVYLKSQLNCLLLSG 278
Cdd:cd22857  239 YVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPELPLIASCGLDRYLRIWDTETRQ-LLSKVYLKQRLTAVVFDS 317


                 ....*...
gi 564332772 279 RDNWEDEP 286
Cdd:cd22857  318 SFSPEEEA 325
 
Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 17-286 2.03e-92

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 278.73  E-value: 2.03e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772  17 TGILKGVNLQRK--LAANFTP--SGQPRREEAVNALCWGT-GGETQILVGCADRTVRHFNAEEG----TFQ--SQRYCPG 85
Cdd:cd22857    1 LGLVKVVEARGKqeEAAPKVVdrWGGPDKSKAVQALSIADrESEPLLAVARKNGTVEVLDPENGdllaSFSdsEPATKLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772  86 GEGTFRGLAqADDGTLITCVDSGILRVW-CENDKEASSDPL----------------------------------LELK- 129
Cdd:cd22857   81 EEDHFVGLH-LFSGTLLTCTSKGSLRSTkLPDDSTASSSPTawvclggnllcmrvdpnenyfafggkevelnvwdLEEKp 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 130 --------VRNDWLDLRVPIWDQDIQFLPGSQ--KLVTCTGYHQVRIYDPASpQRRPVLEATYGEYPLTAMTLTPEGNSV 199
Cdd:cd22857  160 gkiwraknVPNDSLGLRVPVWVTDLTFLSKDDhrKIVTGTGYHQVRLYDTRA-QRRPVVSVDFGETPIKAVAEDPDGHTV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 200 IVGNTHGQLAEIDFRQGRLLGCLKGLAG-SVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRgLEHKVYLKSQLNCLLLSG 278
Cdd:cd22857  239 YVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPELPLIASCGLDRYLRIWDTETRQ-LLSKVYLKQRLTAVVFDS 317


                 ....*...
gi 564332772 279 RDNWEDEP 286
Cdd:cd22857  318 SFSPEEEA 325
WD40 COG2319
WD40 repeat [General function prediction only];
42-261 2.64e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.10  E-value: 2.64e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772  42 EEAVNALCWGTGGETqILVGCADRTVRHFNAEEGtfQSQRYCPGGEGTFRGLAQADDG-TLITCVDSGILRVWcendKEA 120
Cdd:COG2319  162 SGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLW----DLA 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 121 SSDPLLELKVRNDWldlrvpIWDqdIQFLPGSQKLVTCTGYHQVRIYDPASPQRRPVLEATYGeyPLTAMTLTPEGNSVI 200
Cdd:COG2319  235 TGKLLRTLTGHSGS------VRS--VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG--GVNSVAFSPDGKLLA 304

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564332772 201 VGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRGL 261
Cdd:COG2319  305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 215-253 1.38e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.38e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 564332772   215 QGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIH 253
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 17-286 2.03e-92

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 278.73  E-value: 2.03e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772  17 TGILKGVNLQRK--LAANFTP--SGQPRREEAVNALCWGT-GGETQILVGCADRTVRHFNAEEG----TFQ--SQRYCPG 85
Cdd:cd22857    1 LGLVKVVEARGKqeEAAPKVVdrWGGPDKSKAVQALSIADrESEPLLAVARKNGTVEVLDPENGdllaSFSdsEPATKLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772  86 GEGTFRGLAqADDGTLITCVDSGILRVW-CENDKEASSDPL----------------------------------LELK- 129
Cdd:cd22857   81 EEDHFVGLH-LFSGTLLTCTSKGSLRSTkLPDDSTASSSPTawvclggnllcmrvdpnenyfafggkevelnvwdLEEKp 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 130 --------VRNDWLDLRVPIWDQDIQFLPGSQ--KLVTCTGYHQVRIYDPASpQRRPVLEATYGEYPLTAMTLTPEGNSV 199
Cdd:cd22857  160 gkiwraknVPNDSLGLRVPVWVTDLTFLSKDDhrKIVTGTGYHQVRLYDTRA-QRRPVVSVDFGETPIKAVAEDPDGHTV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 200 IVGNTHGQLAEIDFRQGRLLGCLKGLAG-SVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRgLEHKVYLKSQLNCLLLSG 278
Cdd:cd22857  239 YVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPELPLIASCGLDRYLRIWDTETRQ-LLSKVYLKQRLTAVVFDS 317


                 ....*...
gi 564332772 279 RDNWEDEP 286
Cdd:cd22857  318 SFSPEEEA 325
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 14-280 4.87e-63

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 203.63  E-value: 4.87e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772  14 GTETGILKGvnLQRKLAANFtpsGQPRREEAVNALCWGTGGETQILVGCADR--TVRHFNAEEG------TFQSQRYCPG 85
Cdd:cd22850   11 GTDTSVQDA--AQPKVVETH---LSEGLSNAVQRLSLVDRSDPLLLVARRNGngEVYVLSPVDGelfellSSIEGLTRSK 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772  86 GEGTFRGLAQADDGTLITCVD-SGILRVWCENDKEASS----------DPLL-------------------ELK------ 129
Cdd:cd22850   86 EEDKFVGLHLLRSLGLLTCATkSGLLHIIDLEDSKKDSlevkapltlpGFLSafrvnptdegvfayggkenDLKlwdlek 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 130 -------------VRNDWLDLRVPIWDQDIQFLPGS----QKLVTCTGYHQVRIYDPASpQRRPVleatYGEYPLTAMTL 192
Cdd:cd22850  166 dflklkqiwkaknVKNDRLDLRVPVWITAITFLPPDdhrkFKFVTGTRYGQVRLYDTSA-GRRPV----FSEKPIKKPEE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 193 TPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAG-SVRGLQCHPS--KPLLASCGLDRVLRIHRIRNPRgLEHKVYLKS 269
Cdd:cd22850  241 DLDGHTVYVGDTSGDLALIDIRTGKLLGRLLGKYGgSITGAVRHPElfDPYLASGGLDRYLRVFDIETRE-LLAKVYLGK 319

                        330
                 ....*....|..
gi 564332772 270 Q-LNCLLLSGRD 280
Cdd:cd22850  320 QiLTVVVLDDEE 331
Nsa1 cd22858
Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from ...
 109-316 1.49e-29

Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi is an essential factor for ribosome assembly. In cooperation with the assembly factor Rix7, Nsa1 participates in an early cleavage of the pre-rRNA processing pathway. Rix7 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1 from nucleolar pre-60S particles. The release of Nsa1 from a discrete preribosomal particle may trigger the progression of 60S ribosome biogenesis. Nsa1 is essential for cell viability in yeast. It contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439304  Cd Length: 399  Bit Score: 116.93  E-value: 1.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 109 ILRVWCENDKEASSDPLLELK-VRNDWLDLRVPIWDQDIQFLPGSQ------KLVTCTGYHQVRIYDpASPQRRPVLEAT 181
Cdd:cd22858  173 IVELFSDKKKFFKLKQIWEAKnVKNDRLDLRVPIWITGILFLKPSPskgfdyKFITVTRYGHLRKYD-TTHGRKPIKSYK 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 182 YGEYPLTAMTLTpegnSVIVGNTHGQLAE-----IDFR--------QGRLLGCLKG--LAGSVRGLQCHPSKpLLASCGL 246
Cdd:cd22858  252 LLPKPELTEPLT----ELIISDTHSLIAKlslitTDSKksvsagdgKGRLLGKYGGgdITGAVSAVDVFEDK-YLATGGL 326

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564332772 247 DRVLRIHRIRNpRGLEHKVYLKSQLN-CLLLSGRDnwEDEPQEPQEPNL---VPPEDTETD--ELWASLEAAAKRK 316
Cdd:cd22858  327 DRYLRVFDLET-RELLAKVYVGSKISsVLLLDDED--IELPESEKKKKKkkkRKEEEEEEDdeELWNELEEKKKKR 399
WD40 COG2319
WD40 repeat [General function prediction only];
42-261 2.64e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.10  E-value: 2.64e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772  42 EEAVNALCWGTGGETqILVGCADRTVRHFNAEEGtfQSQRYCPGGEGTFRGLAQADDG-TLITCVDSGILRVWcendKEA 120
Cdd:COG2319  162 SGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLW----DLA 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 121 SSDPLLELKVRNDWldlrvpIWDqdIQFLPGSQKLVTCTGYHQVRIYDPASPQRRPVLEATYGeyPLTAMTLTPEGNSVI 200
Cdd:COG2319  235 TGKLLRTLTGHSGS------VRS--VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG--GVNSVAFSPDGKLLA 304

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564332772 201 VGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRGL 261
Cdd:COG2319  305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365
WD40 COG2319
WD40 repeat [General function prediction only];
42-257 6.11e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 6.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772  42 EEAVNALCWGTGGETqILVGCADRTVRHFNAEEGTFQSQRycPGGEGTFRGLAQADDG-TLITCVDSGILRVWcendkEA 120
Cdd:COG2319  204 TGAVRSVAFSPDGKL-LASGSADGTVRLWDLATGKLLRTL--TGHSGSVRSVAFSPDGrLLASGSADGTVRLW-----DL 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 121 SSDPLLE-LKVRNDWLdlrvpiwdQDIQFLPGSQKLVTCTGYHQVRIYDPASPQRRPVLEAtyGEYPLTAMTLTPEGNSV 199
Cdd:COG2319  276 ATGELLRtLTGHSGGV--------NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG--HTGAVRSVAFSPDGKTL 345

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564332772 200 IVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRN 257
Cdd:COG2319  346 ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-259 1.65e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 1.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772  45 VNALCWGTGGETqILVGCADRTVRHFNAEEGTFQSQRYcpGGEGTFRGLAQ-ADDGTLITCVDSGILRVWCENDKEASS- 122
Cdd:cd00200   12 VTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVAAsADGTYLASGSSDKTIRLWDLETGECVRt 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 123 -----DPLLELKVRND-------WLDLRVPIWD-----------------QDIQFLPGSQKLVTCTGYHQVRIYDPASPQ 173
Cdd:cd00200   89 ltghtSYVSSVAFSPDgrilsssSRDKTIKVWDvetgkclttlrghtdwvNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 174 RRPVLEATYGeyPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIH 253
Cdd:cd00200  169 CVATLTGHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246


                 ....*.
gi 564332772 254 RIRNPR 259
Cdd:cd00200  247 DLRTGE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-252 1.46e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 1.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772  42 EEAVNALCWGTGGetQILVGC-ADRTVRHFNAEEGTFQSQryCPGGEGTFRGLAQADDGTLITCVDS-GILRVWcenDKE 119
Cdd:cd00200   93 TSYVSSVAFSPDG--RILSSSsRDKTIKVWDVETGKCLTT--LRGHTDWVNSVAFSPDGTFVASSSQdGTIKLW---DLR 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 120 ASSdPLLELKVRNDWLdlrvpiwdQDIQFLPGSQKLVTCTGYHQVRIYDPASPQrrpvLEATYG--EYPLTAMTLTPEGN 197
Cdd:cd00200  166 TGK-CVATLTGHTGEV--------NSVAFSPDGEKLLSSSSDGTIKLWDLSTGK----CLGTLRghENGVNSVAFSPDGY 232

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564332772 198 SVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRI 252
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
142-259 2.10e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 2.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772 142 WDQDIQFLPGSQKLVTCTGYHQVRIYDPASPQRRPVLEATYGeyPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGC 221
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG--AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 564332772 222 LKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPR 259
Cdd:COG2319  158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-259 1.02e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 1.02e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564332772 186 PLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPR 259
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-168 5.17e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.17  E-value: 5.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332772  42 EEAVNALCWGTGGEtQILVGCADRTVRHFNAEEGTFQSQryCPGGEGTFRGLAQADDGTLIT-CVDSGILRVWcendKEA 120
Cdd:cd00200  177 TGEVNSVAFSPDGE-KLLSSSSDGTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPDGYLLAsGSEDGTIRVW----DLR 249

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564332772 121 SSDPLLELKVRNDwldlrvPIWDqdIQFLPGSQKLVTCTGYHQVRIYD 168
Cdd:cd00200  250 TGECVQTLSGHTN------SVTS--LAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 215-253 1.38e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.38e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 564332772   215 QGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIH 253
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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