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Conserved domains on  [gi|530421183|ref|XP_005274612|]
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gem-associated protein 8 isoform X1 [Homo sapiens]

Protein Classification

GEMIN8 domain-containing protein( domain architecture ID 10634022)

GEMIN8 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GEMIN8 pfam15348
Gemini of Cajal bodies-associated protein 8; GEMIN8 proteins are found in the nuclear bodies ...
115-343 1.41e-152

Gemini of Cajal bodies-associated protein 8; GEMIN8 proteins are found in the nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies themselves. They are also found in the cytoplasm. The family is part of the SMN (survival motor neurone) complex that plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. GEMIN8 binds directly to SMN1 and mediates the interaction of the GEMIN6-GEMIN7 heterodimer.


:

Pssm-ID: 464664  Cd Length: 230  Bit Score: 427.91  E-value: 1.41e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421183  115 PWYSHPVYARYWQHYHQAMAWMQSHHNAYRKAVESCFNLPWYLPSALLPQSSYDNEAAYPQSFYDHHVAWQDYPCSSSHF 194
Cdd:pfam15348   1 PWYSHPVYARYWQHYHQAMAWMRSHQNAYRKAMESYYSSPWYFPPAELPQSRYADWGGDPQSFRDHHLASQDSHCSYSHS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421183  195 RRSGQHPRYSSRIQASTKE-DQALSKEEEMETESDAEVECDLSNMEITEELRQYFAETERHREERRRQQQLDAERLDSYV 273
Cdd:pfam15348  81 RRSGQRPRDSRRKQVSTRErDQALHSEEEEESESDGEVECDLSNMEITEELRQYFAETERHREERRRQQQLEAERLDDYV 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421183  274 NADHDLYCNTRRSVEAPTERPGERRQAEMKRLYGDSAAKIQAMEAAVQLSFDKHCDRKQPKYWPVIPLKF 343
Cdd:pfam15348 161 NADHDLYYNTRRSVEPPAERPGERRQAEMKRLYGDSAAKIQAMETAMQLSFDKHCDRKQPKYWPVIPLKL 230
 
Name Accession Description Interval E-value
GEMIN8 pfam15348
Gemini of Cajal bodies-associated protein 8; GEMIN8 proteins are found in the nuclear bodies ...
115-343 1.41e-152

Gemini of Cajal bodies-associated protein 8; GEMIN8 proteins are found in the nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies themselves. They are also found in the cytoplasm. The family is part of the SMN (survival motor neurone) complex that plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. GEMIN8 binds directly to SMN1 and mediates the interaction of the GEMIN6-GEMIN7 heterodimer.


Pssm-ID: 464664  Cd Length: 230  Bit Score: 427.91  E-value: 1.41e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421183  115 PWYSHPVYARYWQHYHQAMAWMQSHHNAYRKAVESCFNLPWYLPSALLPQSSYDNEAAYPQSFYDHHVAWQDYPCSSSHF 194
Cdd:pfam15348   1 PWYSHPVYARYWQHYHQAMAWMRSHQNAYRKAMESYYSSPWYFPPAELPQSRYADWGGDPQSFRDHHLASQDSHCSYSHS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421183  195 RRSGQHPRYSSRIQASTKE-DQALSKEEEMETESDAEVECDLSNMEITEELRQYFAETERHREERRRQQQLDAERLDSYV 273
Cdd:pfam15348  81 RRSGQRPRDSRRKQVSTRErDQALHSEEEEESESDGEVECDLSNMEITEELRQYFAETERHREERRRQQQLEAERLDDYV 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421183  274 NADHDLYCNTRRSVEAPTERPGERRQAEMKRLYGDSAAKIQAMEAAVQLSFDKHCDRKQPKYWPVIPLKF 343
Cdd:pfam15348 161 NADHDLYYNTRRSVEPPAERPGERRQAEMKRLYGDSAAKIQAMETAMQLSFDKHCDRKQPKYWPVIPLKL 230
 
Name Accession Description Interval E-value
GEMIN8 pfam15348
Gemini of Cajal bodies-associated protein 8; GEMIN8 proteins are found in the nuclear bodies ...
115-343 1.41e-152

Gemini of Cajal bodies-associated protein 8; GEMIN8 proteins are found in the nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies themselves. They are also found in the cytoplasm. The family is part of the SMN (survival motor neurone) complex that plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. GEMIN8 binds directly to SMN1 and mediates the interaction of the GEMIN6-GEMIN7 heterodimer.


Pssm-ID: 464664  Cd Length: 230  Bit Score: 427.91  E-value: 1.41e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421183  115 PWYSHPVYARYWQHYHQAMAWMQSHHNAYRKAVESCFNLPWYLPSALLPQSSYDNEAAYPQSFYDHHVAWQDYPCSSSHF 194
Cdd:pfam15348   1 PWYSHPVYARYWQHYHQAMAWMRSHQNAYRKAMESYYSSPWYFPPAELPQSRYADWGGDPQSFRDHHLASQDSHCSYSHS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421183  195 RRSGQHPRYSSRIQASTKE-DQALSKEEEMETESDAEVECDLSNMEITEELRQYFAETERHREERRRQQQLDAERLDSYV 273
Cdd:pfam15348  81 RRSGQRPRDSRRKQVSTRErDQALHSEEEEESESDGEVECDLSNMEITEELRQYFAETERHREERRRQQQLEAERLDDYV 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421183  274 NADHDLYCNTRRSVEAPTERPGERRQAEMKRLYGDSAAKIQAMEAAVQLSFDKHCDRKQPKYWPVIPLKF 343
Cdd:pfam15348 161 NADHDLYYNTRRSVEPPAERPGERRQAEMKRLYGDSAAKIQAMETAMQLSFDKHCDRKQPKYWPVIPLKL 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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