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Conserved domains on  [gi|530396836|ref|XP_005274079|]
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P2Y purinoceptor 6 isoform X3 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11607484)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
27-312 3.44e-174

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


:

Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 484.38  E-value: 3.44e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15379    1 VLLPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALA 186
Cdd:cd15379   81 YTNLHGSILFLTCISVQRYLGICHPLASWHKKKGKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVCYDLSPPARS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPA--EPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLA 264
Cdd:cd15379  161 TAYFPYGITLTRTGFLLPFAARLACYCSMATILCRVVIAVavVAAPGEKRGKAARMIIVVAAVFLISFLPFHYTKTRYLQ 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 265 VRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRP 312
Cdd:cd15379  241 VRSWDGGPCTTRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRPRT 288
 
Name Accession Description Interval E-value
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
27-312 3.44e-174

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 484.38  E-value: 3.44e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15379    1 VLLPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALA 186
Cdd:cd15379   81 YTNLHGSILFLTCISVQRYLGICHPLASWHKKKGKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVCYDLSPPARS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPA--EPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLA 264
Cdd:cd15379  161 TAYFPYGITLTRTGFLLPFAARLACYCSMATILCRVVIAVavVAAPGEKRGKAARMIIVVAAVFLISFLPFHYTKTRYLQ 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 265 VRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRP 312
Cdd:cd15379  241 VRSWDGGPCTTRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRPRT 288
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
44-300 4.84e-44

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 151.68  E-value: 4.84e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836   44 NICVITQICTSRRALTRTAVYTLNLALADLLYA-CSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSlLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  123 QRYLGICHPLAPWHKRGGRRaAWLVCVAVWLAVTTQCLPTAIFAATGIQR--NRTVCyDLSPPALATHYMPYGMALTVIG 200
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRR-AKVLILVIWVLALLLSLPPLLFGWTLTVPegNVTVC-FIDFPEDLSKPVSYTLLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  201 FLLPFAALLACYCLLACRLCRQDGP-AEPVAQERRGKAARMAVVVAAAFAISFLPFHItktayLAVRSTPGVPCTVLEAF 279
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASKqKSSERTQRRRKALKTLAVVVVVFILCWLPYHI-----VNLLDSLALDCELSRLL 234
                         250       260
                  ....*....|....*....|.
gi 530396836  280 AAAYKGTRPFASANSVLDPIL 300
Cdd:pfam00001 235 DKALSVTLWLAYVNSCLNPII 255
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
32-317 4.80e-32

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 122.19  E-value: 4.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITqICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYaQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:PHA03087  46 VYSTIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYY-ILFQWSFGEFACKIVSGLYYIGFY 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVC---YDLSppalATH 188
Cdd:PHA03087 124 NSMNFITVMSVDRYIAIVHPVK-SNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICcmfYNNK----TMN 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMPY-GMALTVIGFLLPFAALLACYCLLACRLCRQDgpaepvAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRS 267
Cdd:PHA03087 199 WKLFiNFEINIIGMLIPLTILLYCYSKILITLKGIN------KSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHIL 272
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 530396836 268 TPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQ 317
Cdd:PHA03087 273 HFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLK 322
 
Name Accession Description Interval E-value
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
27-312 3.44e-174

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 484.38  E-value: 3.44e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15379    1 VLLPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALA 186
Cdd:cd15379   81 YTNLHGSILFLTCISVQRYLGICHPLASWHKKKGKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVCYDLSPPARS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPA--EPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLA 264
Cdd:cd15379  161 TAYFPYGITLTRTGFLLPFAARLACYCSMATILCRVVIAVavVAAPGEKRGKAARMIIVVAAVFLISFLPFHYTKTRYLQ 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 265 VRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRP 312
Cdd:cd15379  241 VRSWDGGPCTTRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRPRT 288
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
27-312 2.16e-148

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 418.80  E-value: 2.16e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15968    1 ILLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGgRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALA 186
Cdd:cd15968   81 YFNLYGSILFLTCISVHRYLGICHPMRPWHKET-RRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCYDLAPPALF 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVR 266
Cdd:cd15968  160 PHYVPYGMALTVSGFLLPFSIILWCYCLVVRTLCRTLGPAEPPAQARRRKSIRTIVTVTLLFALCFLPFHITRTIYLAVR 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 530396836 267 STPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRP 312
Cdd:cd15968  240 VTPGVPCHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKFGRRP 285
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
27-312 1.15e-128

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 368.57  E-value: 1.15e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15168    1 IFLPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKrGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALA 186
Cdd:cd15168   81 YFNLYGSILFLTCISVHRYLGICHPLRSLGK-LKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYDTTSPEEL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGpaEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVR 266
Cdd:cd15168  160 NDYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLG--EGVTSALRRKSIRLVIIVLALFAVCFLPFHVTRTINLAAR 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 267 STPGV-PCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRP 312
Cdd:cd15168  238 LLSGTaSCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
28-311 1.14e-87

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 264.70  E-value: 1.14e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd16001    2 LLPVTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALAT 187
Cdd:cd16001   82 TNLYGSILFLTCISVHRFLGVCYPIRSLAYR-TRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRTVCYDLTSPDNFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 188 HYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEpVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRS 267
Cdd:cd16001  161 NYFPYGMVLTVTGFLIPFLIILLCYCLMIKSLIRSEEAAG-VGKAARAKSIRTILLVCGLFALCFVPFHITRTIYLFVRV 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 530396836 268 TPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd16001  240 YLVQDCPLLQFVSLAYKIWRPLVSFNSCINPLLYFLSGDSNRLR 283
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
28-311 4.36e-75

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 232.54  E-value: 4.36e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd14982    2 LFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQ-RNRTVCYDLSPPALA 186
Cdd:cd14982   82 INMYGSILFLTCISVDRYLAVVHPLKSRRLR-RKRYAVGVCAGVWILVLVASVPLLLLRSTIAKeNNSTTCFEFLSEWLA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 ThYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEpvAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVR 266
Cdd:cd14982  161 S-AAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQ--KSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVR 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 530396836 267 STPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd14982  238 LSFIADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKR 282
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
27-311 1.11e-73

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 228.92  E-value: 1.11e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15374    1 ILLPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWhKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALA 186
Cdd:cd15374   81 YANLYCSILFLTCISVHRYVGICHPIRAL-RWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLCHDTTRPEEF 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQD-GPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAV 265
Cdd:cd15374  160 DHYVHYSSAVMVLLFGIPCLVIVVCYGLMARRLCKPRvGSSRQQGPSSKKRSLKTIIMVLTVFAICFVPFHITRTLYYVA 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 530396836 266 RSTpGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15374  240 RLL-KADCDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYRRR 284
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
27-310 1.88e-67

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 212.69  E-value: 1.88e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15373    1 ILLPVSYGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWhKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALA 186
Cdd:cd15373   81 YTNLYCSILFLLCISVHRFLGVCYPVRSL-RWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITCHDTSSPELF 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRgKAARMAVVVAAAFAISFLPFHITKTAYLAVR 266
Cdd:cd15373  160 DQFVVYSSVMLVLLFCVPFVVILVCYALMVRKLLKPSAGTSTNSRSKK-KSVKMIIIVLAVFILCFLPFHVTRTLYYSFR 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 530396836 267 STPgVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15373  239 SMD-LSCGTLNAINLAYKVTRPLASANSCLDPILYFLAGQSFRS 281
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
29-311 2.69e-56

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 184.34  E-value: 2.69e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  29 LPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYA 108
Cdd:cd15377    3 LPAVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 109 NLHGSILFLTCISFQRYLGICHPLAPWhKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTV-CYDLSPPALAT 187
Cdd:cd15377   83 NLYGSILFLTCISVHRYTGVVHPLKSL-GRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTItCYDTTSDEYLR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 188 HYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQD-GPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVR 266
Cdd:cd15377  162 SYFIYSMCTTVAMFCVPFILILGCYGLIVRALIYKDmKYTEENNAPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRAR 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 267 ---STPGVpCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15377  242 ldfQTPAM-CAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRR 288
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
28-311 1.21e-55

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 182.20  E-value: 1.21e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15967    2 FLPPVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKGRKWIFGQVFCKITRFCFN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLvCVAVWLAVTTQCLPTAIFAATgiQRNRTVCYDLSPPALAT 187
Cdd:cd15967   82 LNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVI-SALVWLLVVIQSLPDLFFSKT--NSNGTKCFDTTFNDYLE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 188 HYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGpAEPVAQERRGKaarMAVVVAAAFAISFLPFHITKTAYLAVR- 266
Cdd:cd15967  159 SYLTYSLGWTVTGFVIPLLIILGCYGHVVVVLCRNNN-VDKGLKQRCLK---LVIILIVLFSVCYIPYHVFRNLNLLSRi 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 530396836 267 -STPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15967  235 lQKQGSCTQWFRGIYIAHQVSRGLVCLNSALNPLVYLMGSEDILSR 280
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
29-310 2.33e-54

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 179.12  E-value: 2.33e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  29 LPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYA 108
Cdd:cd15375    3 LPVMYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINGESWIFGEFMCKFIRFIFHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 109 NLHGSILFLTCISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATH 188
Cdd:cd15375   83 NLYGSILFLTCFSIFRYVVIVHPLR-AFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEKNNRTICLDFTSSDNLNT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMPYGMALTVIGFLLPFAALLACYCLLACRLCRqdGPAepVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRST 268
Cdd:cd15375  162 IWWYNWILTVLGFLLPLVIVTLCYTRIIYTLAK--GPH--TGSASKQKARRLIILILLVFYVCFLPFHILRVVRIETRLP 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 530396836 269 PgVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15375  238 P-VSCCLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQ 278
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
28-301 5.70e-45

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 154.85  E-value: 5.70e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQ-ICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15376    2 FLWPILGVEFLVAVLGNGLALWLfVTRERRPWHTGVVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPwHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGI-QRNRTVCYDLSPPAL 185
Cdd:cd15376   82 TCNLYGSIFFITCISLNRYLGIVHPFFT-RSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLEVeRHNKTECLGTAVDSR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 186 ATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGpaepVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAV 265
Cdd:cd15376  161 LPTYLPYSLFLAVVGCGLPFLLTLASYLAIVWAVLRSPG----ITTLEKRKVAALVAVVVALYAVSFVPYHILRNLNLYR 236
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 530396836 266 RSTPGVPCTVLEAFaAAYKGTRPFASANSVLDPILF 301
Cdd:cd15376  237 RLQWLKAAASLRIY-FAYQVTKGLVTLNMCIHPLLY 271
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
29-309 6.70e-45

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 154.49  E-value: 6.70e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  29 LPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDhWPFGDFACRLVRFLFYA 108
Cdd:cd15378    3 LPTMYSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSYSNGQ-WLFGDFLCKSNRYLLHA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 109 NLHGSILFLTCISFQRYLGICHPLAPwHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATH 188
Cdd:cd15378   82 NLYSSILFLTFISIDRYLLIKYPFRE-HILQKKRSAVAISLAIWVLVTLELLPILTFIGPNLKDNVTKCKDYASSGDATN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGP-AEPVAQErrgKAARMAVVVAAAFAISFLPFHITKTAYLAVR- 266
Cdd:cd15378  161 SLIYSLFLTVTGFLIPLCVMCFFYYKIALFLKNRNRQlANATSFE---KPLTLVILAVVIFSVLFTPYHVMRNVRIASRl 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 530396836 267 -STPGVPCTvLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15378  238 dSIGVSECT-LIIIKSLYIVTRPIAFLNSVINPVFYFLMGDHFR 280
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
28-311 2.73e-44

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 153.28  E-value: 2.73e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15159    2 LLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGFDWPFGDWLCRLTALLFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWlVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLsPPALAT 187
Cdd:cd15159   82 INTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRY-ICVFVWVLVFLQTLPLLFMPMTKEMGGRITCMEY-PNFEKI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 188 HYMPYG-MALTVIGFLLPFAALLACYCLLACRLCRQdGPAEPVAQE--RRGKAARMAVVVAAAFAISFLPFHITKTAYLA 264
Cdd:cd15159  160 KRLPLIlLGACVIGFGVPVGIILFCYSQITLKLCRT-AKENPLTEKsgHHKKACNVILLVLLVFVVCFSPYHLNIIQFMI 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 265 VRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15159  239 RKLLYQPSCSELKAFKISLQITVCLMNLNCCLDPFIYFFACKGYKKK 285
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
28-311 4.37e-44

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 152.53  E-value: 4.37e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd14985    2 VIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVIS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPwHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGI--QRNRTVCYDLSPPal 185
Cdd:cd14985   82 VNMFASIFLLTCMSVDRYLAIVHPVAS-RRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAieNLNKTACIMLYPH-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 186 ATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRgKAARMAVVVAAAFAISFLPFHITKTAYLAV 265
Cdd:cd14985  159 EAWHFGLSLELNILGFVLPLLIILTCYFHIARSLRKRYERTGKNGRKRR-KSLKIIFALVVAFLVCWLPFHFFKFLDFLA 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 530396836 266 RSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd14985  238 QLGAIRPCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQK 283
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
44-300 4.84e-44

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 151.68  E-value: 4.84e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836   44 NICVITQICTSRRALTRTAVYTLNLALADLLYA-CSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSlLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  123 QRYLGICHPLAPWHKRGGRRaAWLVCVAVWLAVTTQCLPTAIFAATGIQR--NRTVCyDLSPPALATHYMPYGMALTVIG 200
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRR-AKVLILVIWVLALLLSLPPLLFGWTLTVPegNVTVC-FIDFPEDLSKPVSYTLLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  201 FLLPFAALLACYCLLACRLCRQDGP-AEPVAQERRGKAARMAVVVAAAFAISFLPFHItktayLAVRSTPGVPCTVLEAF 279
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASKqKSSERTQRRRKALKTLAVVVVVFILCWLPYHI-----VNLLDSLALDCELSRLL 234
                         250       260
                  ....*....|....*....|.
gi 530396836  280 AAAYKGTRPFASANSVLDPIL 300
Cdd:pfam00001 235 DKALSVTLWLAYVNSCLNPII 255
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
27-310 6.13e-44

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 152.15  E-value: 6.13e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLN---ICVITQICTSRRALtrtAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVR 103
Cdd:cd15160    1 IFLPVVYSFVFVVGLPANclaLWVLYLQIKKENVL---GVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 104 FLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTtqcLPTAIFAAT----GIQRNRTVCYD 179
Cdd:cd15160   78 FFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLR-TRRFALKVSASIWVLEL---GTHSVFLGHdelfRDEPNHTLCYE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 180 LSPpaLATHYMPYGMALTVIGFLLPFAALLACYCLLAcRLCRQDGPAEpvaQERRGKAARMAVVVAAAFAISFLPFHITK 259
Cdd:cd15160  154 KYP--MEGWQASYNYARFLVGFLIPLSLILFFYRRVL-RAVRQSPSLE---REEKRKIIGLLLSIVVIFLLCFLPYHVVL 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530396836 260 TAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15160  228 LVRSVIELVQNGLCGFEKRVFTAYQISLCLTSLNCVADPILYIFVTEDVRQ 278
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
27-310 2.68e-43

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 150.29  E-value: 2.68e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15162    1 VFLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLvCVAVWLAVTTQCLPTAIFAATG--IQRNRTVCYD-LSPP 183
Cdd:cd15162   81 YGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGT-CLAIWLLALLVTLPLYLVKQTIflPALDITTCHDvLPEQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 184 ALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLcrqDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYL 263
Cdd:cd15162  160 LLVGDWFYYFLSLAIVGFLIPFILTASCYVATIRTL---AALEDENSEKKKKRAIKLAATVLAIFIICFAPSNLLLLAHY 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 264 AVRSTPGVpctvlEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15162  237 SLISSSGT-----GHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFRD 278
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
27-310 3.62e-43

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 150.06  E-value: 3.62e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAqgDHWPFGDFACRLVRFLF 106
Cdd:cd14984    1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAA--DGWVFGSFLCKLVSALY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLaPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALA 186
Cdd:cd14984   79 TINFYSGILFLACISIDRYLAIVHAV-SALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEDTA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYmPYGMALT--VIGFLLPFAALLACYCLLACRLCRQDGPaepvaqeRRGKAARMAVVVAAAFAISFLPFHITKTAYLA 264
Cdd:cd14984  158 TTW-KTLLRLLqnILGFLLPLLVMLFCYSRIIRTLLRARNH-------KKHRALRVIFAVVVVFFLCWLPYNIVLLLDTL 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 265 VRSTPGVP-CTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd14984  230 QLLGIISRsCELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKFRK 276
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
27-311 3.92e-43

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 149.96  E-value: 3.92e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15921    1 LFYPTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALA 186
Cdd:cd15921   81 YVNMYSSIYFLTALSVFRYLALVWPYLYLRVQ-THSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRCLELAHDAVD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMPYGMALtVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRgKAARMAVVVAAAFAISFLPFHITKTAYLAVR 266
Cdd:cd15921  160 KLLLINYVTL-PVGFVVPFMTVIFCYIFIIKNLLKPSPALGRTRPSRR-KACALIIISLGIFLVCFLPYHIVRTIHLITE 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 530396836 267 STPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15921  238 RQIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSR 282
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
27-311 2.59e-42

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 147.83  E-value: 2.59e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDhWPFGDFACRLVRFLF 106
Cdd:cd14970    1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGY-WPFGEVMCKIVLSVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWlVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALA 186
Cdd:cd14970   80 AYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKL-VSLCVWALSLVLGLPVIIFARTLQEEGGTISCNLQWPDPP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMPYGMALT-VIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRG---KAARMAVVVAAAFAISFLPFHITKTAY 262
Cdd:cd14970  159 DYWGRVFTIYTfVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGAREKRRarrKVTRLVLVVVAVFVVCWLPFHVFQIVR 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530396836 263 LAV--RSTPGVPCTVLEAFAAAYkgtrpfasANSVLDPILFYFTQKKFRRR 311
Cdd:cd14970  239 LLIdpPETLTVVGVFLFCIALSY--------ANSCLNPILYAFLDENFRKS 281
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
28-310 1.87e-41

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 145.68  E-value: 1.87e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdHWPFGDFACRLVRFLFY 107
Cdd:cd15154    2 LHLVGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANH-YWPFGNFLCQFSGSIFQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATG--IQRNRTV--CYDLSPP 183
Cdd:cd15154   81 MNMYGSCLFLMCINVDRYLAIVHPLRFRHLR-RPKVARLLCLAVWALILGGSVPAAIVHSSSdcLLHGEKVyrCFESFSD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 184 ALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPaepvAQERRGKAARMAVVVAAAFAISFLPFHITKTAYL 263
Cdd:cd15154  160 NDWKGLLPLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEP----QQGRRRKTVRLLLVNLVIFLICFVPYNTTLAVYG 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530396836 264 AVRStpgvpcTVLEAFAAAYKGTRP-------FASANSVLDPILFYFTQKKFRR 310
Cdd:cd15154  236 LLRA------NLVEDTWNIKDTLRKvlsvtvlLASTNCALDPLVYYFSTEGFRN 283
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
28-310 6.13e-41

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 144.47  E-value: 6.13e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15922    2 AIPVFLSLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAAPLLIAYFSLGSHWPFGQFLCQLKVFLLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICH--PLAPWHKRGGRRAawlVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPAL 185
Cdd:cd15922   82 THMYGSIYFLMLISIHRYVTVVHynWKSLWKKKSFMKK---LCLGVWLLLFVQGLPFFFVLKTSVIDGKTKCLSIHQSEL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 186 ATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDgPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAV 265
Cdd:cd15922  159 SLLYFVWNFVLLILGFLLPFGVSLTCYALLGASIAKMN-SNNARGRAMKAKSLQMIGISLVIFIICFVPLHVTRTVGVVV 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 530396836 266 RSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15922  238 KLFYPESCTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRK 282
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
27-311 5.46e-40

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 141.77  E-value: 5.46e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15161    1 ILFALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDL-----S 181
Cdd:cd15161   81 YLNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAH-VVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQLyrekaS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 182 PPALAThympygmalTVIGFLLPFAALLACYCLLACRLcRQDGPAEPVAQErrgKAARMAVVVAAAFAISFLPFHITKTA 261
Cdd:cd15161  160 RGALVS---------LAVAFTIPFVTTVTCYLLIIRSL-RTGKREEKPLKD---KAIKMIILVLTIFLICFVPYHISRYI 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 530396836 262 YLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15161  227 YILSHNGAGASCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKFRET 276
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
30-311 1.73e-39

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 140.23  E-value: 1.73e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  30 PPVYSAVLAAGL---PLNICVITQicTSRRAlTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15157    4 PTVYLIIFVLGVvgnGLSIYVFLQ--PSKKK-TSVNIFMLNLAVSDLMFVSTLPFRADYYLMGSHWVFGDIACRIMSYSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRaAWLVCVAVWLAVTTqCLPTAIFAATGIQRNRTVCYDLSPPALA 186
Cdd:cd15157   81 YVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKY-ARILCAVIWIFVMA-ASSPLLSKGTSKYNSQTKCLDLHPSKID 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMPYGMALtVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRgKAARMAVVVAAAFAISFLPFHITKTAYLAVR 266
Cdd:cd15157  159 KLLILNYIVL-VVGFILPFCTLSICYILIIKALLKPRVPQSKLRVSHK-KALLTIIITLILFLLCFLPYHILRTVHLMQW 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 530396836 267 STPGVPCTVLEAFAAaykgTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15157  237 SEGQCNLRLHKAVVI----TLCLAAANSCLDPLLYYFAGENFKER 277
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-311 4.34e-39

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 139.90  E-value: 4.34e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTA-VYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15190   12 LIPVIYMLVFVLGLSGNGLVLWTVFRSKRKRRRSAdTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYLV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVcVAVWLAVTTQCLPTAIFAATGIQR--NRTVCY-DLSPP 183
Cdd:cd15190   92 FVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVAL-GVIWLLAALLALPALILRTTSDLEgtNKVICDmDYSGV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 184 ALATHYMPY----GMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITK 259
Cdd:cd15190  171 VSNESEWAWiaglGLSSTVLGFLLPFLIMLTCYFFIGRTVARHFSKLRRKEDKKKRRLLKIIITLVVTFALCWLPFHLVK 250
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530396836 260 TAY-LAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15190  251 TLYaLMYLGILPFSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
32-311 1.01e-38

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 138.34  E-value: 1.01e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15158    6 LYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYALYVNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRGGRRaAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDlsPPA------- 184
Cdd:cd15158   86 CSIYFMTAMSFTRFLAIVFPVQNLNLVTVKK-ARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKCFE--PPQsnqqltk 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 -LATHYMPYgmaltVIGFLLPFAALLACYCLLACRLCRQDGPAEPvAQERRGKAARMAVVVAAAFAISFLPFHITKTAYL 263
Cdd:cd15158  163 lLVLNYISL-----VVGFIIPFLVILICYAMIIRTLLKNTMKARK-QQSSRKKAIRMIIIVLLAFLVSFMPYHIQRTIHL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 264 AVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15158  237 HFLSRKDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRR 284
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
32-311 3.02e-38

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 137.02  E-value: 3.02e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLL-IYNYAqgdHWPFGDFACRLVRFLFYANL 110
Cdd:cd15178    6 IYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWaVSVVK---GWIFGTFMCKLVSLLQEANF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHplAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRN--RTVCYDLSPPALATH 188
Cdd:cd15178   83 YSGILLLACISVDRYLAIVH--ATRALTQKRHLVKFVCAGVWLLSLLLSLPALLNRDAFKPPNsgRTVCYENLGNESADK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMpygMALTVI----GFLLPFAALLACYCLLACRLCRQDGpaepvaqERRGKAARMAVVVAAAFAISFLPFHITKTAYLA 264
Cdd:cd15178  161 WR---VVLRILrhtlGFLLPLVVMLFCYGFTIKTLLQTRS-------FQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTL 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 265 VRSTPGV-PCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15178  231 MRTKLITeTCELRNHVDVALYVTQILGFLHSCINPVLYAFIGQKFRNN 278
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
32-310 9.81e-38

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 135.82  E-value: 9.81e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYnYAQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15155    6 VYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIF-YNFNRHWPFGDSLCKISGTAFLTNIY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYD-LSPPALATHYM 190
Cdd:cd15155   85 GSMLFLTCISVDRFLAIVYPFRSRTIR-TRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEgFSKSIWKTYLS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 191 PYGMALTVIGFLLPFAALLACYCLLaCRLCRQDGPAEPVAQERRgKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPG 270
Cdd:cd15155  164 KITIFIEVVGFIIPLLLNLTCSSLV-LRTLRKPATLSQIGTNKE-KVLKMILVHVAIFVVCFVPYNSILFLYALVRSQAI 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 530396836 271 VPCTVlEAFA-AAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15155  242 ANCGV-ERFArTMYPITLCLATLNCCFDPFVYYFTSESFQK 281
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
32-304 1.13e-37

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 135.49  E-value: 1.13e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLVRFLFYANL 110
Cdd:cd00637    4 LYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLlVIPFSLVSLLLG-RWWFGDALCKLLGFLQSVSL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLAPwHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPalATHYM 190
Cdd:cd00637   83 LASILTLTAISVDRYLAIVHPLRY-RRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPD--LTLSK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 191 PYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAF--------AISFLPFHITKTAY 262
Cdd:cd00637  160 AYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRRRRERKVTKTllivvvvfLLCWLPYFILLLLD 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 530396836 263 LAVRSTPGVPCTVLEAFAAaykgtrpFASANSVLDPILFYFT 304
Cdd:cd00637  240 VFGPDPSPLPRILYFLALL-------LAYLNSAINPIIYAFF 274
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
27-309 2.64e-36

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 131.79  E-value: 2.64e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTaVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15372    1 RLVPSLYTLVFLVGLPANGLALWVLATQVKRLPST-IFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAAT-GIQR-NRTVCYDLSP-P 183
Cdd:cd15372   80 YGNMYCSVLLLMCISLDRYLAVVHPFFARTLR-SRRFALCMCTAIWLIAAALTLPLTLQRQSyPLERlNITLCHDVLPlD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 184 ALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQdgpaepvaQERRGKAARMAVVVAAAFAISFLPFHITKTAYL 263
Cdd:cd15372  159 EQDTYLFYYFACLAVLGFLLPLVVILFCYGSVLHTLLRS--------GQRYGHAMKLTVLVLVSFVLCFTPSNLLLLLHY 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 530396836 264 AVRSTPGvpctvLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15372  231 SDPTLDD-----GGNLYIVYMVSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
29-311 4.62e-34

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 126.04  E-value: 4.62e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  29 LPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYA 108
Cdd:cd15368    3 LPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVLFYA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 109 NLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGI--QRNRTVCYDLSP---- 182
Cdd:cd15368   83 NMYSSILTMTCISIERYLGVVYPMRSMRWR-KKRYAVAACIGMWLLVLTALSPLERTDLTYYvkELNITTCFDVLKwtml 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 183 PALAtHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQdgpAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAY 262
Cdd:cd15368  162 PNIA-AWAAFLFTLFILLFLIPFIITVYCYVLIILKLVQT---SERYGREQKRRAIYLALIVLLVFITCFAPNNFILLAH 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 263 LAVRSTPGvpctvlEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15368  238 MVSRLFYG------KSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKK 280
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
32-304 6.53e-34

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 125.73  E-value: 6.53e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQgDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15156    6 VFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQ-RNWPFGDLLCKISVTLFYTNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRN---RTVCYDLSPPALATH 188
Cdd:cd15156   85 GSILFLTCISVDRFLAIVYPFRSKTLR-TKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQLNnnsETCFENFSSKTWKTY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMPYGMALTVIGFLLPFAALLACYCLLACRLCRqdgpaePVAQER----RGKAARMAVVVAAAFAISFLPFHITKTAYLA 264
Cdd:cd15156  164 LSKIVIFIEIVGFFIPLILNVTCSTMVLKTLRR------PNTLSRsklnKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 530396836 265 VRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFT 304
Cdd:cd15156  238 VRTQTFKNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFT 277
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
29-310 2.84e-33

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 124.09  E-value: 2.84e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  29 LPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdhWPFGDFACRLVRFLFYA 108
Cdd:cd15174    3 LPPLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAASSG--WVFGTFLCKVVNSMYKI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 109 NLHGSILFLTCISFQRYLGICHPL-APWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALAT 187
Cdd:cd15174   81 NFYSCMLLLTCISVDRYIAIVQATkAHNSKNKRLLYSKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMVYPSNESN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 188 HYMPYGMALTV-IGFLLPFAALLACYCLLACRLCRQDGpaepvaqERRGKAARMAVVVAAAFAISFLPFHItktaYLAVR 266
Cdd:cd15174  161 RFKVAVLALKVtVGFFLPFVVMVICYTLIIHTLLQAKR-------FQKHKALKVIIAVVTVFVLSQLPYNS----ILLIK 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 267 STPG-----VPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15174  230 TINAynitiTDCATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRK 278
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
31-311 3.01e-33

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 123.57  E-value: 3.01e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  31 PVYSAVLAAGLPLNICVItQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANL 110
Cdd:cd14974    5 VLYALIFLLGLPGNGLVI-WVAGFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSFVISLNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPlAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYM 190
Cdd:cd14974   84 FASVFLLTAISLDRCLLVLHP-VWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTCVEDYDLRRS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 191 PYgMALTVI----GFLLPFAALLACYCLLACRLcRQDGPAepvaqeRRGKAARMAVVVAAAFAISFLPFHI------TKT 260
Cdd:cd14974  163 RH-KALTVIrflcGFLLPLLIIAICYSVIAVKL-RRKRLA------KSSKPLRVLLAVVVAFFLCWLPYHVfallelVAA 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530396836 261 AYLAVRSTPGVPCTVLeafaaaykgtrpFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd14974  235 AGLPEVVLLGLPLATG------------LAYFNSCLNPILYVFMGQDFRKR 273
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
29-311 9.05e-33

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 122.55  E-value: 9.05e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  29 LPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYA 108
Cdd:cd15193    3 IPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 109 NLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATgiqRNRTVCYDLSPPALath 188
Cdd:cd15193   83 NRCSSILFLTGMSVDRYLAVVKLLDSRPLR-TRRCALITCCIIWAVSLVLGIPSLVYRNL---INESVCVEDSSSRF--- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRgKAARMAVVVAAAFAISFLPFHITKTAYLAVRST 268
Cdd:cd15193  156 FQGISLATLFLTFVLPLIVILFCYCSILVRLRRHFHGAKRTGRRRR-NSLRIVFAIVTAFVLSWLPFNTLKAVRLLLELG 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 530396836 269 PGV-PCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15193  235 GGVlPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFRRR 278
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
27-311 2.89e-32

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 121.41  E-value: 2.89e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15088    1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFaATGIQRN--RTVCY-DLSPP 183
Cdd:cd15088   81 ANNQFTSTYILTAMSVDRYLAVVHPIRSTKYR-TRFVAKLVNVGLWAASFLSILPVWVY-SSLIYFPdgTTFCYvSLPSP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 184 ALATHYMPYgmaLTVIGFLLPFAALLACYCLLACRLCRQDGPAEP-VAQERRGKAARMAVVVAAAFAISFLPFHITKTAY 262
Cdd:cd15088  159 DDLYWFTIY---HFILGFAVPLVVITVCYILILHRLARGVAPGNQsHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLVN 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 263 LavrsTPGVPCTvleAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15088  236 L----AMNRPTL---AFEVAYFLSICLGYANSCLNPFVYILVSENFRKR 277
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
32-317 4.80e-32

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 122.19  E-value: 4.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITqICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYaQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:PHA03087  46 VYSTIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYY-ILFQWSFGEFACKIVSGLYYIGFY 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVC---YDLSppalATH 188
Cdd:PHA03087 124 NSMNFITVMSVDRYIAIVHPVK-SNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICcmfYNNK----TMN 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMPY-GMALTVIGFLLPFAALLACYCLLACRLCRQDgpaepvAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRS 267
Cdd:PHA03087 199 WKLFiNFEINIIGMLIPLTILLYCYSKILITLKGIN------KSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHIL 272
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 530396836 268 TPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQ 317
Cdd:PHA03087 273 HFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLK 322
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
27-311 5.88e-32

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 120.61  E-value: 5.88e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15192    1 IMIPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGI--QRNRTVCYDLSPPA 184
Cdd:cd15192   81 SFNLYASVFLLTCLSIDRYLAIVHPMKSRLRR-TLVVARVTCIVIWLLAGVASLPAIIHRDVFFieNTNITVCAFHYPSQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 LATHymPYGMALT--VIGFLLPFAALLACYCLLACRL--CRQDGPAEPVAQErrgkAARMAVVVAAAFAISFLPFHITKT 260
Cdd:cd15192  160 NSTL--LVGLGLMknLLGFLIPFLIILTCYTLIGKALkkAYEIQRNKPRNDE----IFKMIMAVVLFFFFCWIPHQIFTF 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530396836 261 AYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15192  234 LDVLIQLKVIQDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFRKK 284
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
28-303 2.75e-31

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 118.73  E-value: 2.75e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15365    2 LFPFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLLY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTtqclptaIFAATGI--------QRNRTVCYD 179
Cdd:cd15365   82 TNFYTSTALLTCIALDRYLAVVHPLKFMHLR-TIRTALSVSVAIWLLEI-------CFNAVILtwedsfheSSSHTLCYD 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 180 LSPPALatHYMPYGMALTVIGFLLPFAALLACYcllaCRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITk 259
Cdd:cd15365  154 KFPLED--WQARLNLFRICLGYLLPLLIILFCY----WKIYQAVRSNQATEDQEKKKIFKLLLLITVTFVICFTPYHVV- 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 530396836 260 tayLAVRST--PGVpCTVLEAFAAAYKGTRPFASANSVLDPILFYF 303
Cdd:cd15365  227 ---LLIRSIvePCD-CRNAKWLYTLYKITVALTSLNCIADPFLYCF 268
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
29-309 2.99e-31

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 118.70  E-value: 2.99e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  29 LPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYA 108
Cdd:cd14991    3 LPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNLFMLSV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 109 NLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVaVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATH 188
Cdd:cd14991   83 NRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGL-LWALVLLLTLPLLLSTLLTVNSNKSSCHSFSSYTKPSL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEpvaQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRst 268
Cdd:cd14991  162 SIRWHNALFLLEFFLPLGLIVFCSVRIACNLRIRQSLGK---QARVQRAIRLVFLVVIVFVLCFLPSIIAGLLALVFK-- 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 530396836 269 PGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd14991  237 NLGSCRCLNSVAQLFHISLAFTYLNSALDPVIYCFSSPWFR 277
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
27-309 7.19e-31

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 117.59  E-value: 7.19e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15366    1 LFPPTLYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAATGIQR-NRTVCYDLSPpal 185
Cdd:cd15366   81 YTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAV-AVSAVVWAIEIGANSAPLFHDELFRDRyNHTFCFEKYP--- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 186 athyMPYGMAL-----TVIGFLLPFAALLACYCLLaCRLCRQDGPAEpvaQERRGKAARMAVVVAAAFAISFLPFHITKT 260
Cdd:cd15366  157 ----MEDWVAWmnlyrVFVGFLFPWVLMLFSYRGI-LRAVRGNVSTE---QQEKAKIKRLALSLIAIVLLCFAPYHVLLL 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 261 AYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15366  229 SRSVVYLGKPCDCGFEERVFTAYHVSLALTSLNCVADPILYCLVNEGAR 277
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
33-309 7.29e-31

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 117.59  E-value: 7.29e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQgDHWPFGDFACRLVRFLFYANLHG 112
Cdd:cd15153    7 YIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQ-HTWPFGRFLCLLCFYLKYLNMYA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 113 SILFLTCISFQRYLGICHPLAPwhKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYdlspPALATHYMPY 192
Cdd:cd15153   86 SICFLTCISIQRCFFLLHPFKA--RDWKRRYDVGISAAVWIVVGLACLPFPLLRSKSLSNNNRSCF----ADLGMKKLNF 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 193 GMALTVI------GFLLPFAALLacYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVR 266
Cdd:cd15153  160 GAAIAMMtvaelfGFVIPLFIIA--WCTWKTENSLRQRNKQQQSTSEKQKALRMVRMCAAVFFICFAPYHINFLFYLMVS 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 530396836 267 STPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15153  238 ESIITNCEVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
27-309 1.55e-30

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 116.82  E-value: 1.55e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15370    1 VFLPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLApwHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNR--TVCYDLSPPA 184
Cdd:cd15370   81 YGNMYCSILFMTCLSVQRYWVIVNPMS--HSRKKANIAIGISLAIWLLILLVTIPLYLVKQTVFIPALdiTTCHDVLPEQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 LATHYM-PYGMALTVIGFLLPFAALLACYCLLACRLcrQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYL 263
Cdd:cd15370  159 LLVGDMfNYFLSLAIGVFLFPAFLTAVAYVLMIRAL--KSSINDESIEKKRKRAIKLIVTVLVMYLICFTPSNLLLVVHY 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 530396836 264 AVrstpgVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15370  237 FL-----LKNQGQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
32-311 1.65e-30

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 116.75  E-value: 1.65e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15152    6 TYTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNK-SWPFGKFLCMFCFYLKYVNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLApWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGiQRNRTVCYDLSPpalathYMP 191
Cdd:cd15152   85 ASIYFLVCISVRRCLYLIYPFR-YNDC-KRKCDVYISIAGWLVVCVGCLPFPLLRQSQ-DTNPTCCFADLP------LRN 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 192 YGMALTVI--------GFLLPFAALLACYCLLACRLcRQDGPAEPVAQERRgKAARMAVVVAAAFAISFLPFHITKTAYL 263
Cdd:cd15152  156 VGLTTSVImltiaeltGFVTPLLIVLYCSWKTVMSL-REKTPVLQDLGEKK-KALKMILTCAVVFLICFAPYHISFPLDF 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 264 AVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15152  234 LVKSNKIKSCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFKRR 281
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
32-312 4.14e-29

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 112.81  E-value: 4.14e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQgdHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15165    6 VYIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSSKK--QWPLGRTLCSFLESLYFVNMY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPtaIFAATGIQRNRTVC-YDLSPPALATHYM 190
Cdd:cd15165   84 GSILIIVCISVDRYIAIRHPFLAKRLRSPRKAA-IVCLTIWVFVWAGSIP--IYSFHDKPTNNTRCfHGFSNKTWSKKVI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 191 PYGMaltVIGFLLPFAALLAC-----YCLLACRLCRQDgpaepvaQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAV 265
Cdd:cd15165  161 VVVE---EFGFLIPMAVMVFCsvqiiRTLLDMRRPEQP-------KVKQNKSVKIVLSNLVVFLVCFTPYHLGIFLQFLV 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 266 RSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRP 312
Cdd:cd15165  231 KNDIINDCSTKQSIRLFVQVSMCLANVNCCLDAICYYFILKEFRESA 277
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
30-310 1.85e-28

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 111.02  E-value: 1.85e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  30 PPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdhWPFGDFACRLVRFLFYAN 109
Cdd:cd15177    4 PCVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAETLQG--WIFGNAMCKLIQGLYAIN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LHGSILFLTCISFQRYLGI-CHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCyDLSPPALATH 188
Cdd:cd15177   82 FYSGFLFLTCISVDRYVVIvRATSAHRLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSSC-RMIFPEVVSR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMPYGMALT--VIGFLLPFAALLACYCLLACRLCRQDGPaepvaqeRRGKAARMAVVVAAAFAISFLPFHIT---KTAYL 263
Cdd:cd15177  161 TVKGATALTqvVLGFAIPLIVMAVCYAAIGRTLLAARGW-------ERHRALRVIAALVVAFVLFQLPYSVVlllDTADL 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 264 AvrSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15177  234 L--ATLELSCSQSKRKDIALLVTSGLAYVRCCLNPLLYAFVGVRFRR 278
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
28-303 4.82e-28

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 109.85  E-value: 4.82e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15367    2 LFPVVYILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHDNWTYSELLCKICGILLY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLptAIFAATGIQR---NRTVCYDLSPPA 184
Cdd:cd15367   82 ENIYISIGFLCCISVDRYLAVVHPFR-FHAFRTMKAATLVSTVIWLKELMTCV--FFFLHGEISKdkeNHSVCFEHYPIK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 LATHYMPYGMALtvIGFLLPFAALLACYcllaCRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHItktaYLA 264
Cdd:cd15367  159 AWEHNINYYRFY--AGFLFPIFLLSFSY----CRILRAVRKSHGTQKSQKIQIKRLVLSTVVIFLVCFGPYHI----LLL 228
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 530396836 265 VRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYF 303
Cdd:cd15367  229 VRSVFERDCNFAEGIFNYYHFSLLLTSFNCVADPVLYCF 267
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
27-309 1.66e-27

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 108.74  E-value: 1.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQI--CTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRF 104
Cdd:cd14976    1 NLVSVVYMVVFTVGLLGNLLVLYLLksNKKLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 105 LFYANLHGSILFLTCISFQRYLGICHPLAP-WHKrgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQR-NRTVCYDLSP 182
Cdd:cd14976   81 VTKLNMYSSIFFLTALSVTRYIAVARALKHgWIR--KAFGAFATTIAIWAAAALAAIPEAIFSTDTWSSvNHTLCLLRFP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 183 PALATHYMPYGMAL-----TVIGFLLPFAALLACYCLLACRLCRQDGPaepvAQERRGKAARMAVVVAAAFAISFLPFHI 257
Cdd:cd14976  159 KNSSVTRWYNWLGMyqlqkVVLGFFLPLGIITLSYLLLLRFLQRKRGG----SKRRKSRVTKSVFIVVLSFFICWLPNQA 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530396836 258 TkTAYLAVRSTPGVPCTvLEAFAA---AYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd14976  235 L-SLWSALIKFDDVPFS-DAFFAFqtyAFPVAICLAHSNSCLNPVLYCLVRREFR 287
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
28-310 1.98e-27

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 108.21  E-value: 1.98e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15201    2 VLPPVLILEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFRTDYYLRGKHWKFGDIPCRIVLFMLA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVaVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALAT 187
Cdd:cd15201   82 MNRAGSIFFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACG-LWLLTIAMTVYLLTKKHLFPRGNATQCESFNICTGTD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 188 HYMPYGMALTVIGFLLPFAALLACYCLLACRLcRQDGPAEpvaQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRS 267
Cdd:cd15201  161 SSSNWHEAMFLLEFFLPLAIILYCSVRIIWQL-RGRQLDR---HAKIKRAVQFIMVVAIVFIICFLPSNVTRIAIWILKH 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 530396836 268 TPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15201  237 TSNEDCQYYRSVDLAFYITISFTYFNSMLDPVVYYFSSPSFKN 279
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
28-215 3.48e-27

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 107.57  E-value: 3.48e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTrTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15371    2 LIPAVYIIVVVLGVPSNAIILWMLFFRLRSVC-TAIFYANLAISDLLFCITLPFKIVYHLNGNNWVFGETMCRIITITFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATG--IQRNRTVCYDLSPPAL 185
Cdd:cd15371   81 GNMYCSILLLTCISINRYLAIVHPFI-YRSLPKKTYAVLICALVWTIVFLYMLPFFILKQTYylKELNITTCHDVLPECE 159
                        170       180       190
                 ....*....|....*....|....*....|..
gi 530396836 186 ATHYMP--YGMALTVIGFLLPFAALLACYCLL 215
Cdd:cd15371  160 QNSNFQfyYFISMAVFGFLIPLVITIFCYISI 191
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
28-311 3.79e-27

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 107.53  E-value: 3.79e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15191    2 AIPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRggRRAAWLVCVAVWLAVTTQCLPTAIFAATGI--QRNRTVCYDLSPPAL 185
Cdd:cd15191   82 LNLFASIFFITCMSVDRYLAVVYPLRSQRRR--SWQARLVCLLVWVLACLSSLPTFYFRDTYYieELGVNACIMAFPNEK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 186 ATHYMPyGMAL--TVIGFLLPFAALLACYCLLACRLCRQDGPAepVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYL 263
Cdd:cd15191  160 YAQWSA-GLALmkNTLGFLIPLIVIATCYFGIGRHLLKTKGFG--KNKQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDA 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 264 AVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15191  237 LARMGVINNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFREK 284
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
27-309 3.83e-27

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 107.52  E-value: 3.83e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdhWPFGDFACRLVRFLF 106
Cdd:cd15176    1 LFLPVFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAVNG--WVLGTAMCKITSALY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHplAPWHKRGGRRaAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALA 186
Cdd:cd15176   79 TMNFSCGMQFLACISVDRYVAITK--ATSRQFTGKH-CWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRCLPVFPPSLV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMPYGMALTV-IGFLLPFAALLACYCLLACRLCRqdgpaepVAQERRGKAARMAVVVAAAFAISFLPFHITK------ 259
Cdd:cd15176  156 TSAKATIQILEVlLGFVLPFLVMVFCYSRVARALSR-------TPNVKKSRALKVLLAVVGVFIVTQLPYNVVKfyraid 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 530396836 260 TAYLAVRStpgvpCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15176  229 VIYLLITD-----CSMSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
28-310 6.15e-27

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 107.14  E-value: 6.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICV--ITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFL 105
Cdd:cd15147    2 LFPIVYSIIFVLGLIANCYVlwVFARLYPSKKLNEIKIFMVNLTIADLLFLITLPFWIVYYHNEGNWILPKFLCNVAGCL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 106 FYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAATGIQ----RNRTVC---- 177
Cdd:cd15147   82 FFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGI-IISVAIWVIIVASASYFLFMDSTNTVkidsGNFTRCfegy 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 178 -YDLSPPALATHYmpygmaLTVIGFLLPFAALLACYCLLACRLCRQdgpaePVAQERRG----KAARMAVVVAAAFAISF 252
Cdd:cd15147  161 eKDNSKPVLIIHF------IIIGLFFLVFLLILVCNLVIARTLLSQ-----PVQGQRNAgvkrRALWMVCTVLAVFVICF 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 253 LPFHITKTAY-LAV-RSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15147  230 VPHHVVQGPWtLAVlQQWRYWDCQFRQALNDAHQITLCLMSTNCVLDPVIYCFLTKKFRK 289
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
27-309 1.04e-26

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 106.39  E-value: 1.04e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQgdHWPFGDFACRLVRFLF 106
Cdd:cd15923    1 LLQYAIYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSYRR--ESAGLQKLCNFVLSLY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTaifAATGIQRNRTVCYDLSPPALA 186
Cdd:cd15923   79 YINMYVSIFTITAISVDRYVAIRYPLRARELRSPRKAA-VVCAVIWVLVVTISIPY---FLLDSSNEKTMCFQRTKQTES 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMpygMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKaaRMAVVVAAAFAISFLPFHITKTAYLAVR 266
Cdd:cd15923  155 LKVF---LLLEIFGFLLPLIIMTFCSARVIHTLQKRLDDVGSRSETKQCI--RVIMANLIVFIVCFLPVHVGFFVKFIVG 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 530396836 267 STpgVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15923  230 KS--YSCDSKLIIHFFLQSAFCLSDMNCCLDAFCYYFATKEFR 270
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
30-311 1.56e-26

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 106.00  E-value: 1.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  30 PPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYAN 109
Cdd:cd15381    4 PIYLWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYMN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWlVCVAVWLAVTTQCLPTAIFAATGI--QRNRTVCYdLSPPALAT 187
Cdd:cd15381   84 LYSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKL-NCLIIWMFGLLMSTPMIVFRTVMYfpEYNITACV-LDYPSEGW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 188 HyMPYGMALTVIGFLLPFAALLACYCLLACRLcRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITkTAYLAVRS 267
Cdd:cd15381  162 H-VALNILLNVVGFLIPLSIITFCSTQIIQVL-RNNKMQKFKEIQTERKATVLVLAVLLMFFICWLPFHIF-TFLDTLHK 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 530396836 268 TPGVPCTVLEAFAAAYKGTRPF-ASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15381  239 LGLISGCRWEDILDIGTQIATFlAYSNSCLNPLLYVIVGKHFRKK 283
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
28-311 1.57e-26

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 105.93  E-value: 1.57e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdhWPFGDFACRLVRFLFY 107
Cdd:cd15180    2 FLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVHG--WIFGTGLCKLAGAVFK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIF--AATGIQRNRTVCYDLSPPAL 185
Cdd:cd15180   80 INFYCGIFLLACISFDRYLSIVHAVQ-MYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFleATKDPRQNKTECVHNFPQSD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 186 ATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDgpaepvAQERRGKAARMAVVVAAAFAISFLPFHITKTA-YLA 264
Cdd:cd15180  159 TYWWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRSS------QGFQKQRAIRVIVAVVVVFFLCWTPYNIALLVdTLI 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 265 VRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15180  233 DLSVLDRNCGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRK 279
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
32-309 1.67e-26

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 106.00  E-value: 1.67e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd14987    6 FYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIFSINLF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHpLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIF--AATGIQRNRTVCYDLSPPALATHY 189
Cdd:cd14987   86 GSIFFLTCMSVDRYLSVTL-FGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFlkTVTSPSNNETYCRSFYPEESFKEW 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 190 MpYGMALT--VIGFLLPFAALLACYCLLACRLcrqdgpAEPVAQERRgKAARMAVVVAAAFAISFLPFHITK-TAYLAVR 266
Cdd:cd14987  165 L-IGMELVsiVLGFVIPFPIIAVFYFLLARAI------SASSDQERK-SSRKIIFSYVVVFLVCWLPYHTVVlLDILSFL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 530396836 267 STPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd14987  237 HLIPFSCQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYR 279
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
27-310 1.79e-26

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 105.62  E-value: 1.79e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15369    1 RFVPSVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYHFSGNDWLFGEAMCRVVTAAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAAT-GIQR-NRTVCYD-LSPP 183
Cdd:cd15369   81 YCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRAS-FTCAAIWLLSIAGVVPLLLSEQTiQIPDlGITTCHDvLNEQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 184 ALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAepvAQERRGKAARMAVVVAAAFAISFLPFHITKTAYL 263
Cdd:cd15369  160 LLMGYYVYYFSIFSCLFFFVPLIITTVCYVSIIRCLSSSSDVA---NSSKKTRALFMAVAVFCVFVICFGPTNVLLLAHY 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 264 AVRSTPGVPctvlEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15369  237 VRFAYTSTN----DASYFAYLLCVCVGSISCCLDPLIYYYGSSQCQK 279
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
28-310 2.48e-26

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 105.24  E-value: 2.48e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQgDHWPFGDFACRLVRFLFY 107
Cdd:cd15093    2 LIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNAL-RHWPFGSVLCRLVLSVDG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPL--APWHKrggRRAAWLVCVAVWLAVTTQCLPTAIFAATGI-QRNRTVCYDLSPPA 184
Cdd:cd15093   81 INMFTSIFCLTVMSVDRYLAVVHPIksARWRR---PRVAKVVNLAVWVASLLVILPVVVFAGTREnQDGSSACNMQWPEP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 LATHYMPYGMALTVIGFLLPFAALLACYCLLACRLcrQDGPAEPVAQERR---GKAARMAVVVAAAFAISFLPFHITKTA 261
Cdd:cd15093  158 AAAWSAGFIIYTFVLGFLLPLLIICLCYLLIVIKV--KSAGLRAGWQQRKrseRKVTRMVVMVVVVFVICWLPFYVLQLV 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 262 YLAvrstpgVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15093  236 NVF------VQLPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKK 278
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
32-311 3.71e-26

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 105.37  E-value: 3.71e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPL-LIYNYAQGdhWPFGDFACRLVRFLFYAN 109
Cdd:cd14993    6 LYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLfCMPLtLLENVYRP--WVFGEVLCKAVPYLQGVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRN-------RTVCYDLSP 182
Cdd:cd14993   84 VSASVLTLVAISIDRYLAICYPLKARRVS-TKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISsepgtitIYICTEDWP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 183 PALATHYmpYGMALTVIGFLLPFAALLACYCLLACRLCRQDGP----------AEPVAQERRgKAARMAVVVAAAFAISF 252
Cdd:cd14993  163 SPELRKA--YNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPgdrgsanstsSRRILRSKK-KVARMLIVVVVLFALSW 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530396836 253 LPFHITKT-AYLAVRSTpgvpctvlEAFAAAYKGTRPFA----SANSVLDPILFYFTQKKFRRR 311
Cdd:cd14993  240 LPYYVLSIlLDFGPLSS--------EESDENFLLILPFAqllgYSNSAINPIIYCFMSKKFRRG 295
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
28-310 7.49e-26

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 104.17  E-value: 7.49e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15194    2 FLPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYIIS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLsppALAT 187
Cdd:cd15194   82 VNMYCSVFLLTCMSLDRYLAIVLPLVSRKFR-TKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCNED---AGTP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 188 HYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRgKAARMAVVVAAAFAISFLPFHITKTAYLAVRS 267
Cdd:cd15194  158 SKVIFSLVSLIVAFFLPLLSILTCYCTIIWKLCHHYQKSGKHQKKLR-KSIKIVFIVVAAFVFSWMPFNLFKALAIASGL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 530396836 268 TPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15194  237 QVEVTCLPYTLAQLGMEVSAPLAFANSCANPFIYYFFDRYIRR 279
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
29-310 1.15e-25

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 103.31  E-value: 1.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  29 LPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdhWPFGDFACRLVRFLFYA 108
Cdd:cd15173    3 LPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAAHE--WIFGTVMCKITNGLYTI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 109 NLHGSILFLTCISFQRYLGICHPlAPWHKRGGRRAAW--LVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALA 186
Cdd:cd15173   81 NLYSSMLILTCITVDRFIVIVQA-TKAHNCHAKKMRWgkVVCTLVWVISLLLSLPQFIYSEVRNLSSKICSMVYPPDAIE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMPYGMALtviGFLLPFAALLACYCLLACRLCRQDGpaepvaqERRGKAARMAVVVAAAFAISFLPFHITKtaylaVR 266
Cdd:cd15173  160 VVVNIIQMTV---GFFLPLLAMIICYSVIIKTLLHAKG-------FQKHKSLKIIFVVVAVFILTQLPYNIMK-----LI 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 530396836 267 STPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15173  225 RTLHIENTDSTNFKYAILITEAIAYLHACLNPILYAFVGVKFRK 268
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
27-309 1.71e-25

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 103.30  E-value: 1.71e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQgdHWPFGDFACRLVRFLF 106
Cdd:cd15172    1 VFVPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYEAH--QWIFGNFSCKLLRGIY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRA-AWLVCVAVWLAVTTQCLPTAIFAAT--GIQRNRTVC---YDL 180
Cdd:cd15172   79 AINFYSGMLLLACISVDRYIAIVQATKSFRLRSRTLAySKLICAAVWLLAILISLPTFIFSEVydFGLEEQYVCepkYPK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 181 SPPALATHYMPYGMALTvIGFLLPFAALLACYCLLACRLCRqdgpaepVAQERRGKAARMAVVVAAAFAISFLPFHITkT 260
Cdd:cd15172  159 NSTAIMWKLLVLSLQVS-LGFFIPLLVMIFCYSFIIKTLLQ-------AQNSQRHKAVRVVVAVVLVFLVCQVPYNIV-L 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 261 AYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15172  230 LIEAINLGEQQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFR 278
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
32-309 2.56e-25

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 102.51  E-value: 2.56e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVItQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15119    6 IYIVAFVLGVPGNAIVI-WVTGFKWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAVLNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLapW-HKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAAT-GIQRNRTVCY----DLSPPAL 185
Cdd:cd15119   85 ASVLFLTVISLDRYISLAHPV--WsHRYRTLKSALILCGIVWLSAAAISGPALYFRDTmELSINVTICFnnfhKHDGDLI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 186 ATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQdgpaepvAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAV 265
Cdd:cd15119  163 VMRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRR-------TLLISSKFFWTISAVIVAFFVCWTPYHIFSILELSI 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 266 RSTpgvpctvlEAFAAAYKGTRPFASA----NSVLDPILFYFTQKKFR 309
Cdd:cd15119  236 HHS--------SYLHNVLRAGIPLATSlafiNSCLNPILYVLIGKKFK 275
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
27-310 3.46e-25

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 102.30  E-value: 3.46e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIyNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15970    1 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLV-TSTLLRHWPFGSLLCRLVLSVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPL-APWHKRggRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPAL 185
Cdd:cd15970   80 AINMFTSIYCLTVLSIDRYIAVVHPIkAARYRR--PTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGSVACNMQMPEP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 186 ATHYMPYGMALT-VIGFLLPFAALLACYCLLACRLcRQDGPAEPVAQERRG--KAARMAVVVAAAFAISFLPFHITKTAY 262
Cdd:cd15970  158 SQRWLAVFVVYTfLMGFLLPVIAICLCYILIIVKM-RVVALKAGWQQRKRSerKITLMVMMVVTVFVICWMPFYVVQLVS 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 263 LAVRSTPgvpcTVLEAFAAAykgtrpFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15970  237 VFVGQHD----ATVSQLSVI------LGYANSCANPILYGFLSDNFKR 274
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
33-311 3.69e-25

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 102.16  E-value: 3.69e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHG 112
Cdd:cd14988    7 YLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYFYFANMYS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 113 SILFLTCISFQRYLGICHPLAPWHkRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATgIQRNRTVCYDLSP-PALATHYMP 191
Cdd:cd14988   87 SIFFLTCLSVDRYLTLTSSSPFWQ-QHQHRIRRALCAGIWVLSAIIPLPEVVHMQL-LDGVEPMCLFLAPfETYDEWALA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 192 YGMALTVIGFLLPFAALLACYCLLACRLCRQDGPaepvaQERRgkAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGV 271
Cdd:cd14988  165 VSLLTLIIGFLIPFSIIAVFNVLTARYIRTAGRP-----ESRR--HCLLIYAYILVFVVCWLPYHVTLLLLTLHGSHISL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 530396836 272 PCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd14988  238 HCNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGK 277
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
32-310 5.70e-25

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 101.76  E-value: 5.70e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITqICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15116    6 IYSVVFVLGVLGNGLVIF-ITGFKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNSFLLFLNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRGGRRaAWLVCVAVWLAVTTQCLPTAIFAATGIQR--NRTVC---YDLSPPALA 186
Cdd:cd15116   85 TSVFLLTVISIDRCISVVFPVWSQNHRSVRL-ASLVSLAVWVVAFFLSSPSFIFRDTAPSQnnNKIICfnnFSLSGDNSS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMPYG----MALTVI----GFLLPFAALLACYCLLACRLcRQDGPAepvaqeRRGKAARMAVVVAAAFAISFLPFHI- 257
Cdd:cd15116  164 PEVNQLRnmrhQVMTITrfllGFLIPFTIIICCYAAIVLKL-KRNRLA------KSSKPFKIIAAVIVTFFLCWAPYHIl 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530396836 258 -----TKTAYLAVRSTPGVPCTVLEAFaaaykgtrpfasANSVLDPILFYFTQKKFRR 310
Cdd:cd15116  237 nllemEATRSPASVFKIGLPITSSLAF------------INSCLNPILYVFMGQDFKK 282
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
27-224 8.90e-25

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 101.00  E-value: 8.90e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdhWPFGDFACRLVRFLF 106
Cdd:cd15179    1 IFLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAAN--WYFGNFLCKAVHVIY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLapwHKRGGRR--AAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPA 184
Cdd:cd15179   79 TVNLYSSVLILAFISLDRYLAIVHAT---NSQRPRKllAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYPED 155
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 530396836 185 LATHYM-PYGMALTVIGFLLPFAALLACYCLLACRLCRQDG 224
Cdd:cd15179  156 TFELWVvAFRFQHILVGLVLPGLVILTCYCIIISKLSHSKG 196
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
32-311 9.89e-25

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 101.35  E-value: 9.89e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVItQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15117    6 IYSSAFVLGTLGNGLVI-WVTGFRMTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVVFNLF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWlVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCY------------- 178
Cdd:cd15117   85 ASVFLLTLISLDRCVSVLWPVWARNHRTPARAAL-VAVGAWLLALALSGPHLVFRDTRKENGCTHCYlnfdpwnetaedp 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 179 DLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDgpaepVAQERRGKaaRMAVVVAAAFAISFLPFHIT 258
Cdd:cd15117  164 VLWLETVVQRLSAQVITRFVLGFLVPLVIIGGCYGLIAARLWREG-----WVHSSRPF--RVLTAVVAAFFLCWFPFHLV 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530396836 259 KTAYLAVRST------PGVPCTVLEAFAAAYkgtrpfasANSVLDPILFYFTQKKFRRR 311
Cdd:cd15117  237 SLLELVVILNqkedlnPLLILLLPLSSSLAC--------VNSCLNPLLYVFVGRDFRER 287
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
27-310 1.03e-24

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 100.96  E-value: 1.03e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSR--RALTRTAVYTLNLALADLLYA--CsLPL--LIYNYAQgdhWPFGDFACR 100
Cdd:cd15098    1 VIVPVVFGLIFCLGVLGNSLVITVLARVKpgKRRSTTNVFILNLSIADLFFLlfC-VPFqaTIYSLPE---WVFGAFMCK 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 101 LVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAA---TGIQRNRTVC 177
Cdd:cd15098   77 FVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLR-TRRNALLGVLVIWVLSLAMASPVAVHQDlvhHWTASNQTFC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 178 YDLSPPalATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHI 257
Cdd:cd15098  156 WENWPE--KQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKKLKNMSKKSERSKKKTAQTVLVVVVVFGISWLPHHI 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530396836 258 TkTAYLAVRSTPGVPCT-VLEAFAAAykgtrpFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15098  234 I-HLWVEFGDFPLTQASfVLRITAHC------LAYANSCVNPIIYAFLSENFRK 280
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
31-311 1.94e-24

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 100.17  E-value: 1.94e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  31 PVYSAVLAAGLPLNICVI-TQICTSRRALTrtAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYAN 109
Cdd:cd15114    5 VLYAVVFLVGVPGNALVAwVTGFEAKRSVN--AVWFLNLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSLILLN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LHGSILFLTCISFQRYLGICHPLAPWHKRGGRRaAWLVCVAVWLAVTTQCLPTAIFaatgiqrnRTVCYDLSPPALAThY 189
Cdd:cd15114   83 MYASVLLLTAISADRCLLVLRPVWCQNHRRARL-AWIACGAAWLLALLLTVPSFIY--------RRIHQEHFPEKTVC-V 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 190 MPYG------MALT----VIGFLLPFAALLACYCLLACRLCRQDGpaepvaqERRGKAARMAVVVAAAFAISFLPFHITK 259
Cdd:cd15114  153 VDYGgstgveWAVAiirfLLGFLGPLVVIASCHGVLLVRTWSRRR-------QKSRRTLKVVTAVVVGFFLCWTPYHVVG 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530396836 260 TAYLAVRstpgvPCTVLEAFA-AAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15114  226 LIIAASA-----PNSRLLANAlKADPLTVSLAYINSCLNPIIYVVAGRGFRKS 273
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
32-309 2.01e-24

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 100.45  E-value: 2.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15390    6 VFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPwhkRGGRRAAWLVCVAVWLAVTTQCLPTAIFAAT-----GIQRNRTVCYDLSPPALA 186
Cdd:cd15390   86 ASVFTLMAISIDRYIAIVHPLRP---RLSRRTTKIAIAVIWLASFLLALPQLLYSTTetyyyYTGSERTVCFIAWPDGPN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THY-MPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEP-VAQERR----GKAARMAVVVAAAFAISFLPFHITkt 260
Cdd:cd15390  163 SLQdFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGENtPRQLESvrakRKVVKMMIVVVVIFAICWLPYHLY-- 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530396836 261 aYLAVRSTPGVPCT--VLEAFAAAYKgtrpFASANSVLDPILFYFTQKKFR 309
Cdd:cd15390  241 -FILTYLYPDINSWkyIQQIYLAIYW----LAMSNSMYNPIIYCWMNKRFR 286
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
32-311 2.02e-24

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 99.84  E-value: 2.02e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVItQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15115    6 VLSLTFLLGVPGNGLVI-WVAGLKMKRTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIVLNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVC-YDlsppalatHYM 190
Cdd:cd15115   85 ASVFTLTAISLDRFLLVIKPVWAQNHR-SVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCgYD--------FLV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 191 PYGMALTVIGFLLPFAALLACYCLLACRLCRQDGpaepvaQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPG 270
Cdd:cd15115  156 AITITRAVFGFLLPLLIIAACYSFIAFRMQRGRF------AKSQSKTFRVIIAVVVAFFVCWAPYHIIGILSLYGDPPLS 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 530396836 271 VPCTVLEAFAAAykgtrpFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15115  230 KVLMSWDHLSIA------LAYANSCLNPVLYVFMGKDFKKK 264
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
28-311 2.04e-24

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 100.23  E-value: 2.04e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15189    2 IIPPFIFSLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNGVIK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIF-AATGIQRNRTVCYDLSPPALA 186
Cdd:cd15189   82 VNLYTSIYLLVMISQDRYLALVKTMAARRLR-RRRYAKLICVLIWVVGLLLSIPTFLLrKIKAIPDLNITACVLLYPHEA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMpYGMALTVIGFLLPFAALLAC-YCLLACRLCRQDGPAEPVAQERrgKAARMAVVVAAAFAISFLPFHItkTAYLAV 265
Cdd:cd15189  161 WHFA-HIVLLNIVGFLLPLLVITFCnYNILQALRTREESTRCEDRNDS--KATALVLAVTLLFLVCWGPYHF--FTFLDF 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 266 RSTPGV--PCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15189  236 LFDVGVldECFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRRK 283
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
28-310 8.33e-24

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 98.69  E-value: 8.33e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYA-CSLPLLIYNYAQgDHWPFGDFACRLVRFLF 106
Cdd:cd14971    2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLlFCVPFTATIYPL-PGWVFGDFMCKFVHYFQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGgRRAAWLVCVAVWLAVTTQCLPTAIF--AATGIQRNRTVCYDLSPPA 184
Cdd:cd14971   81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRT-PRNALAASGCIWVVSLAVAAPVLALhrLRNYTPGNRTVCSEAWPSR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 laTHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRG--KAARMAVVVAAAFAISFLPFHITkTAY 262
Cdd:cd14971  160 --AHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSRRAkrKVTRLVLVVVVLFAACWGPIHAI-LLL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 263 LAVRSTPGVPCTVLEAFAAaykgtRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd14971  237 VALGPFPLTYATYALRIWA-----HCLAYSNSAVNPVLYAFLSEHFRK 279
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
27-310 1.46e-23

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 97.82  E-value: 1.46e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdhWPFGDFACRLVRFLF 106
Cdd:cd15182    1 AFLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYHSSG--WIFGEILCKAVTSIF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAAT-GIQRNRTVCYDLSPPAL 185
Cdd:cd15182   79 YIGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYAS-LVSVAVWVISILASLPELILSTVmKSDEDGSLCEYSSIKWK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 186 ATHYMPYgmaltVIGFLLPFAALLACYCLLACRLCRqdgpaepVAQERRGKAARMAVVVAAAFAISFLPFHITktayLAV 265
Cdd:cd15182  158 LGYYYQQ-----NLFFLIPLGIIVYCYVRILQTLMR-------TRTMRKHRTVKLIFVIVLVFFLSWAPYNIV----IFL 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 266 RSTPGVPCTVLEAFAA---AYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15182  222 RSLKDLTIPICECSKQldyAFYICRNIAFSHCCLNPVFYVFVGVKFRN 269
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
27-310 2.02e-23

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 97.50  E-value: 2.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQgDHWPFGDFACRLVRFLF 106
Cdd:cd15087    1 VALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLL-QQWPFGELLCKLILSID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPL----APWHKrggRRAAWLVCVAVWLAVTTQCLPTAIFAAT-GIQRNRTVCYDLS 181
Cdd:cd15087   80 HYNIFSSIYFLTVMSVDRYLVVLATVrsrrMPYRT---YRAAKIVSLCVWLLVTIIVLPFTVFAGVySNELGRKSCVLSF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 182 PPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQER-RGKAARMAVVVAAAFAISFLPFHITKT 260
Cdd:cd15087  157 PSPESLWFKASRIYTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKALDKaKKKVTLMVLVVLAVCLFCWTPFHLSTV 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 530396836 261 AYLavrsTPGVPCTVLeAFAAAYKGTrPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15087  237 VAL----TTDLPQTPL-VIGISYFIT-SLSYANSCLNPFLYAFLDDSFRK 280
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
32-310 2.26e-23

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 97.37  E-value: 2.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDhWPFGDFACRLVRFLFYANLH 111
Cdd:cd15090    6 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGNILCKIVISIDYYNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMP 191
Cdd:cd15090   85 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAK-IVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYWENL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 192 YGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAI-SFLPFHItktaYLAVRSTPG 270
Cdd:cd15090  164 LKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIvCWTPIHI----YVIIKALVT 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 530396836 271 VPCTVLEafAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15090  240 IPETTFQ--TVSWHFCIALGYTNSCLNPVLYAFLDENFKR 277
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
32-310 6.20e-23

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 96.00  E-value: 6.20e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNIcvITQICTSRRALTRT--AVYTLNLALADLLYACSLPLLIYnYAQGDH-WPFGDFACRLVRFLFYA 108
Cdd:cd15364    6 VYSVVFALGFPANC--LTLWLTLLQVRRKNvlAVYLFSLSLCELLYLGTLPLWTI-YVSNNHkWPWGSLACKITGYIFFC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 109 NLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQClpTAIFAATGIQRNRTVCYDLSPpaLATH 188
Cdd:cd15364   83 NIYISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHS--PVFIMREGQTEGSHTCFETLQ--MDTQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMPYGMALTVIGFLLPFAALLacycLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITktayLAVRST 268
Cdd:cd15364  159 VAGFYYARFCIGFAIPLAILI----FTNYRIFRSIQTSTSLTPHQKAKVKYLAIAVIVIFLICFAPYHLV----LLVRAI 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 269 -----PGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15364  231 afslyPNGMCGFEERIYTPSVIFLCLSTVNSVADPIIYVLVSENVRQ 277
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
28-311 7.70e-23

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 96.04  E-value: 7.70e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRAlTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15339    2 ILPSFIGILCSTGLVGNILVLFTIIRSRKK-TVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRT-VC-YDLSPPAL 185
Cdd:cd15339   81 CNQFACSAIMTAMSLDRYIALVHPFRLTSLR-TRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLeSCaFNLTSPDD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 186 ATHYMPYgmaLTVIGFLLPFAALLACYCLLAC---RLCRQDGPAEP----VAQERRGKAARMAVVVAAAFAISFLPFHIT 258
Cdd:cd15339  160 VLWYTLY---QTITTFFFPLPLILICYILILCytwEMYRKNKKAGRyntsIPRQRVMRLTKMVLVLVGVFLVSAAPYHVI 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530396836 259 KTAYLAVrSTPGVpctvleAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15339  237 QLVNLSV-SQPTL------AFYVSYYLSICLSYASSSINPFLYILLSGNFRKR 282
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
32-310 9.94e-23

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 95.40  E-value: 9.94e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNI-CVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANL 110
Cdd:cd15170    6 VYIITFLIGLPANLlAFYTFIRKVRRKPTPIDILLLNLTVSDLIFLLFLPFKMAEAASGMIWPLPYFLCPLSSFIFFSTI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLapWHKRGGRRA-AWLVCVAVWLAVTTQC-----LPTAIFAATGIQRNRTVCYD-LSPP 183
Cdd:cd15170   86 YISTLFLTAISVERYLGVAFPI--KYKLRRRPLyAVIASVFFWVLAFSHCsivyiVEYHIDSENTSVTNNSRCYDnFTPE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 184 ALAThYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQdgpaEPVAQERRGKAARMAVVVAAAFAISFLPFHITK-TAY 262
Cdd:cd15170  164 QLKI-LLPVRLELFLVLFCIPFLITCFCYINFIRILSSL----PHISRQRKQRAIGLAVATLLNFIVCFAPYNISHvVGF 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 263 LAVRSTPGVPCTVLeafaaaykgtrpFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15170  239 IQRKSPEWRMYALL------------LSTLNACLDPIIFYFSSSAVRR 274
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
30-310 1.04e-22

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 95.59  E-value: 1.04e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  30 PPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdhWPFGDFACRLVRFLFYAN 109
Cdd:cd15181    4 PLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAG--WVFGTFLCKLVGAIHKLN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIF--AATGIQRNRTVCYDLSPPALAT 187
Cdd:cd15181   82 FYCSSLLLACISVDRYLAIVHAIHSYRHR-RLRSVHLTCGSIWLVCFLLSLPNLVFleVETSTNANRTSCSFHQYGIHES 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 188 HYMPYGMALT-VIGFLLPFAALLACYCLLACRLCRqdgpaepvAQER--RGKAARMAVVVAAAFAISFLPFHITK-TAYL 263
Cdd:cd15181  161 NWWLTSRFLYhVVGFFLPLLIMGYCYATIVVTLCQ--------SSRRlqKQKAIRVAILVTLVFCLCWLPYNIVIfLDTL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 264 AVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15181  233 DDLKAVVKNCKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFRN 279
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
27-212 1.38e-22

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 95.25  E-value: 1.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAqgDHWPFGDFACRLVRFLF 106
Cdd:cd15187    1 LFLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLL--DQWVFGNAMCKIVSGAY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALA 186
Cdd:cd15187   79 YIGFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGT-ILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYPGQGN 157
                        170       180
                 ....*....|....*....|....*.
gi 530396836 187 THYMPYGMALTVIGFLLPFAALLACY 212
Cdd:cd15187  158 SWKVFTNFEVNILGLLIPFSILIFCY 183
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
32-310 1.60e-22

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 95.23  E-value: 1.60e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15094    6 LYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILK-YWPFGAAMCKIYMVLTSINQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPpalATHYMP 191
Cdd:cd15094   85 TSSFTLTVMSADRYLAVCHPIRSMRYR-TPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWP---DSSAVN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 192 YGMALT----VIGFLLPFAALLACYCLLACRLcRQDGPAEPVAQERRG--KAARMAVVVAAAFAISFLPFHITKTAYLAV 265
Cdd:cd15094  161 GQKAFTlytfLLGFAIPLLLISVFYTLVILRL-RTVGPKNKSKEKRRShrKVTRLVLTVISVYIICWLPYWAFQVHLIFL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 530396836 266 RSTPGVPctvlEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15094  240 PPGTDMP----KWEILMFLLLTVLSYANSMVNPLLYAFLSENFRK 280
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
28-310 3.05e-22

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 94.40  E-value: 3.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTL--NLALADLLY-ACSLPLLIYNYAQGdHWPFGDFACRLVRF 104
Cdd:cd15002    1 LVPILLGVICLLGFAGNLMVIGILLNNARKGKPSLIDSLilNLSAADLLLlLFSVPFRAAAYSKG-SWPLGWFVCKTADW 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 105 LFYANLHGSILFLTCISFQRYLGICHPLapWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPA 184
Cdd:cd15002   80 FGHACMAAKSFTIAVLAKACYMYVVNPT--KQVTIKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYLCILCIPPL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 LATHYMPYGMALTVIGFLLPFAALLACYCLLACRlCRQDGPA--EPVAQERRGKAARMAVVVAAAFAISFLPFHItktAY 262
Cdd:cd15002  158 AHEFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQ-CQRRGTKtqNLRNQIRSRKLTHMLLSVVLAFTILWLPEWV---AW 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 263 LAVR-STPGVPCTvLEAFAAAykgTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15002  234 LWLIhIKSSGSSP-PQLFNVL---AQLLAFSISSVNPIIFLLMSEEFRE 278
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
27-310 3.28e-22

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 94.25  E-value: 3.28e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQgDHWPFGDFACRLVRFLF 106
Cdd:cd15091    1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLM-NSWPFGDVLCKIVISID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAATGIQRNR--TVCyDLSPPA 184
Cdd:cd15091   80 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAK-IINICIWLLSSSVGISAIVLGGTKVREDVdsTEC-SLQFPD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 LATHYMPYGMALTV--IGFLLPFAALLACYCLLACRLCR---QDGPAEPVAQERRgkAARMAVVVAAAFAISFLPFHItk 259
Cdd:cd15091  158 DDYSWWDTFMKICVfiFAFVIPVLIIIVCYTLMILRLKSvrlLSGSREKDRNLRR--ITRLVLVVVAVFVVCWTPIHI-- 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530396836 260 taYLAVRSTPGVPCTVleAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15091  234 --FILVEALGSVSHST--AAVSSYYFCIALGYTNSSLNPILYAFLDENFKR 280
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
28-310 4.59e-22

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 93.75  E-value: 4.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdHWPFGDFACRLVRFLFY 107
Cdd:cd15971    2 FLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALV-HWPFGKAICRVVMTVDG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPL--APWHKrggRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPAL 185
Cdd:cd15971   81 INQFTSIFCLTVMSIDRYLAVVHPIksAKWRK---PRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIWPGES 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 186 ATHYMPYGMALTVIGFLLPFAALLACYCLLACRLcRQDGPAEPVAQERRGKAARMAVVVAAAFAISF--LPFHI--TKTA 261
Cdd:cd15971  158 SAWYTGFIIYTFILGFFVPLTIICLCYLFIIIKV-KSSGIRVGSSKRKKSEKKVTRMVSIVVAVFVFcwLPFYIfnVSSV 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 262 YLAVRSTPGVPCTVLEAFAAAYkgtrpfasANSVLDPILFYFTQKKFRR 310
Cdd:cd15971  237 SVSISPTPGLKGMFDFVVVLSY--------ANSCANPILYAFLSDNFKK 277
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
44-310 9.27e-22

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 93.27  E-value: 9.27e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQ 123
Cdd:cd14992   18 NFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAFD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 124 RYLGICHPLAPWHKRGGRRAAWLVCVaVWLAVTTQCLPTAIFAATGIQRNRTVCYD-----LSPPALATHYMPYGMALTV 198
Cdd:cd14992   98 RYFAIIHPLKPRHRQSYTTTVIIIIT-IWVVSLLLAIPQLYYATTEVLFSVKNQEKifccqIPPVDNKTYEKVYFLLIFV 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 199 IGFLLPFAALLACYCLLACRLCRQDGPAE---PVAQER---RGKAARMAVVVAAAFAISFLPFHITkTAYLAVRSTPGVP 272
Cdd:cd14992  177 VIFVLPLIVMTLAYARISRELWFRKVPGFsikEVERKRlkcKRRVIKMLVCVVVLFVICWLPFHLF-FLLRDFFPLIMKE 255
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 530396836 273 CTVLEAFAAAYKgtrpFASANSVLDPILFYFTQKKFRR 310
Cdd:cd14992  256 KHTLQVYYFLHW----IAMSNSMYNPIIYVTLNNNFRK 289
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
40-309 1.04e-21

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 92.93  E-value: 1.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  40 GLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTC 119
Cdd:cd15199   14 GLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLFMLSLSRGVSIAFLTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 120 ISFQRYLGICHPLAPWHKRGGRRAAWLVCVaVWLAVTTQCLPTAIFAATgiqRNRTVCYDLSPPALATHYMPYGMALTVI 199
Cdd:cd15199   94 VALDRYFRVVHPRGKKNSLSLQAAPYISFL-VWLLLVGLTIPTLLASQP---KNFTECNSFSPKDDEDFSDTWQEAVFFL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 200 GFLLPFAALLACYCLLACRLcrQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGvpCTVLEAF 279
Cdd:cd15199  170 QFLLPFGLIVFCTVRIIRRL--KKRLRDVGKQPKLQRAMALVTSVVVVFGFCFLPCFLARVLMLIFQNKES--CNALNIA 245
                        250       260       270
                 ....*....|....*....|....*....|
gi 530396836 280 AAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15199  246 VHTYDVTMCLTYLNSVLDPIVYCFSSPTFR 275
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
32-308 1.16e-21

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 92.32  E-value: 1.16e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIynYAQGDHWPfGDFACRLVRFLFYANLH 111
Cdd:cd15164    6 IYIPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFSLPFVL--YFLKHSWP-DDELCLVLQSIYFINRY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTqclpTAIFAATGIQRNRTVCY--DLSPPALAThy 189
Cdd:cd15164   83 MSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAA-LTCGLLWVLVII----SVSLRLAWEEQEENFCFgkTSTRPSKRT-- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 190 mpygMALTVIGFLLPFAALLACYCLLACRLCRQDGPAepvAQERRG--KAARMAVVVAAAFAISFLPFHITKTAYLAVRS 267
Cdd:cd15164  156 ----LIFSLLGFFIPLIILSFCSIQVIRSLKKKKKTN---PHEEKLiqKAIYIVSANLIVFIVCFLPLHIGLLVRFVMES 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 530396836 268 TpGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKF 308
Cdd:cd15164  229 N-KASCSLIQNIRNFIYVASCLANANCCLDAICYYFVAKEF 268
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
32-310 1.36e-21

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 92.23  E-value: 1.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQgDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15973    6 IYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAAL-QHWPFGSAMCRTVLSVDGINMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPL-APWHKRggRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDL--SPPALATH 188
Cdd:cd15973   85 TSVFCLTVLSVDRYIAVVHPLrAARYRR--PTVAKMINICVWILSLLVISPIIIFADTATRKGQAVACNLiwPHPAWSAA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMPYgmaLTVIGFLLPFAALLACYCLLACRLcRQDGPAEPVAQERR--GKAARMAVVVAAAFAISFLPFHITKTAYLAVr 266
Cdd:cd15973  163 FVIY---TFLLGFLLPVLAIGLCYILIIGKM-RAVALKAGWQQRRKseKKITRMVLMVVTVFVICWMPFYVVQLLNLFL- 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 530396836 267 stPGVPCTVLEAfaaaykgTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15973  238 --PRLDATVNHA-------SLILSYANSCANPILYGFLSDNFRR 272
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
28-311 1.81e-21

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 92.17  E-value: 1.81e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15380    2 VLPTFIIAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIRNQFNWPFGNFLCRVISGVIK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGI--QRNRTVCYDLSPPAL 185
Cdd:cd15380   82 ANLFISIFLVVAISQDRYRTLVHTMTSRRQR-SRRQAQVICLLIWVFGGLLSIPTFLFRSVKHvpDLNISACILLFPHEA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 186 atHYMPYGMALTVIGFLLPFAALL-ACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLA 264
Cdd:cd15380  161 --WHFARRVELNIVGFLLPLAAIVfFNFHIIASLRERTEESRKRCGGLKDTKATRLILTLVLMFLVCWTPYHFFAFLDFL 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 265 VRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15380  239 FQVEVIQGCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFRTK 285
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
27-310 2.09e-21

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 91.79  E-value: 2.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQgDHWPFGDFACRLVRFLF 106
Cdd:cd15974    1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAI-SYWPFGSFLCRLVMTVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPL--APWHKrggRRAAWLVCVAVWLAVTTQCLPTAIFAAtgIQRNRTVCYDLSPPA 184
Cdd:cd15974   80 GVNQFTSIFCLTVMSIDRYLAVVHPIksTKWRR---PRVAKLINATVWTLSFLVVLPVIIFSD--VQPDLNTCNISWPEP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 LATHYMPYGMALTVIGFLLPFAALLACYCLLACRLcRQDGPAEPVAQERRG--KAARMAVVVAAAFAISFLPFHITKTAY 262
Cdd:cd15974  155 VSVWSTAFIIYTAVLGFFGPLLVICLCYLLIVIKV-KSSGLRVGSTKRRKSerKVTRMVVIIVVVFVFCWLPFYMLNIVN 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 263 LAVrSTPGVPctvleAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15974  234 LIV-ILPEEP-----AFVGVYFFVVVLSYANSCANPILYGFLSDNFKQ 275
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
32-223 2.61e-21

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 91.97  E-value: 2.61e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGDHWPFGDFACRLVRFLFYANL 110
Cdd:cd14997    6 VYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLvCMPVALVETWAREPWLLGEFMCKLVPFVELTVA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPL-APWHKRGGRraAWLVCVAVWLAVTTQCLPtaIFAATGIQRNRTVCYDLSP----PAL 185
Cdd:cd14997   86 HASVLTILAISFERYYAICHPLqAKYVCTKRR--ALVIIALIWLLALLTSSP--VLFITEFKEEDFNDGTPVAvcrtPAD 161
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 530396836 186 ATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQD 223
Cdd:cd14997  162 TFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHP 199
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
27-309 4.29e-21

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 91.00  E-value: 4.29e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTR-TAVYTLNLALADLLYACSLPLLIYNYAQgdHWPFGDFACRLVRFL 105
Cdd:cd15188    1 VFLPVFYTLVFLLGLAGNLLLFVVLLLYVPKKKKmTEVYLLNLAVSDLLFLVTLPFWAMYVAW--HWVFGSFLCKFVSTL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 106 FYANLHGSILFLTCISFQRYLGICHPlAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRT-VCYDLSPPA 184
Cdd:cd15188   79 YTINFYSGIFFVSCMSLDKYLEIVHA-QSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNGVwVCHADYGGH 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 LATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAepvaqerRGKAARMAVVVAAAFAISFLPFHITKTAYLA 264
Cdd:cd15188  158 HTIWKLVFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRPPG-------QGRALRFVAALVVVFFVLWFPYNLTLFLHSL 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 530396836 265 VRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15188  231 QDLHVIGNCERSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFR 275
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
32-310 5.88e-21

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 90.78  E-value: 5.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDhWPFGDFACRLVRFLFYANLH 111
Cdd:cd15089    6 LYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMET-WPFGELLCKAVLSIDYYNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHY-M 190
Cdd:cd15089   85 TSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAK-LINICIWVLSSGVGVPIMVMAVTKTPRDGAVVCMLQFPSPSWYWdT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 191 PYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERR-GKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTP 269
Cdd:cd15089  164 VTKICVFIFAFVVPILVITVCYGLMILRLRSVRLLSGSKEKDRNlRRITRMVLVVVAAFIICWTPIHIFVIVWTLVDIDR 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 530396836 270 GVPCTVleafaAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15089  244 RNPLVV-----AALHLCIALGYANSSLNPVLYAFLDENFKR 279
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-309 7.29e-21

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 90.58  E-value: 7.29e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDhWPFGDFACRLVRFLFY 107
Cdd:cd14999    1 AIGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLKK-WYFGDVGCRLLFSLDF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPwHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAA-----TGIQRNRTVCYDLSP 182
Cdd:cd14999   80 LTMHASIFTLTVMSTERYLAVVKPLDT-VKRSKSYRK-LLAGVIWLLSLLLTLPMAIMIRlvtveDKSGGSKRICLPTWS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 183 PalaTHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEpVAQERRG---KAARMAVVVAAAFAISFLPFHITK 259
Cdd:cd14999  158 E---ESYKVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAAS-NSSRKRLpkqKVLKMIFTIVLVFWACFLPFWIWQ 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 530396836 260 TAYLAVRSTPGVPCTVLEAFAAaykgTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd14999  234 LLYLYSPSLSLSPRTTTYVNYL----LTCLTYSNSCINPFLYTLLTKNYK 279
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
27-310 9.13e-21

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 90.25  E-value: 9.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQgDHWPFGDFACRLVRFLF 106
Cdd:cd15972    1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNAL-SYWPFGSFMCRLVMTVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPL--APWHKrggRRAAWLVCVAVWLAVTTQCLPTAIFAatGIQRNRTVCYDLSPPA 184
Cdd:cd15972   80 AINQFTSIFCLTVMSVDRYLAVVHPIrsSKWRK---PPVAKTVNATVWALSFLVVLPVVIFS--GVPGGMGTCHIAWPEP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 LATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRG---KAARMAVVVAAAFAISFLPFHITKTA 261
Cdd:cd15972  155 AQVWRAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRVRATSTKRRGserKVTRMVVIVVAAFVLCWLPFYALNIV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 262 YLAvrstpgVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15972  235 NLV------CPLPEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQ 277
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
27-310 1.50e-20

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 89.57  E-value: 1.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVItQICTSRRALTRTAV--YTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRF 104
Cdd:cd15926    1 IIISIVYSVVCALGLVGNLLVL-YLMKSKQGWKKSSInlFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 105 LFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLvCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPA 184
Cdd:cd15926   80 VTAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWL-CVLIWVLAILASLPNAIFSTTATVSNEELCLVKFPDN 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 LATHYMPYGMALT---VIGFLLPFAALLACYCLLAcRLCRQDGPAEPVAQeRRGKAARMAVVVAAAFAISFLPFH-ITKT 260
Cdd:cd15926  159 RGNAQFWLGLYHAqkvLLGFLIPLGIISLCYLLLV-RFITDKNITGSSTK-RRSKVTKSVTIVVLSFFLCWLPNQaLTTW 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 530396836 261 AYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15926  237 GILIKLNVVHFSYEYFTTQVYIFPITVCLAHSNSCLNPILYCLMRREFRK 286
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
28-311 1.50e-20

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 89.65  E-value: 1.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLY-ACSLPLLIYNYAQGDhWPFGDFACRLVRFLF 106
Cdd:cd15095    2 LVPLIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFlVCCVPFTAALYATPS-WVFGDFMCKFVNYMM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPL-APWHKRggRRAAWLVCVAVWLAVTTQCLPTAIFAATGI---QRNRTVCYDLSP 182
Cdd:cd15095   81 QVTVQATCLTLTALSVDRYYAIVHPIrSLRFRT--PRVAVVVSACIWIVSFLLSIPVAIYYRLEEgywYGPQTYCREVWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 183 PALA-THYMPYGMALTvigFLLPFAALLACYCLLACRLCRQDGPAE---PVAQERRG----KAARMAVVVAAAFAISFLP 254
Cdd:cd15095  159 SKAFqKAYMIYTVLLT---YVIPLAIIAVCYGLILRRLWRRSVDGNnqsEQLSERALrqkrKVTRMVIVVVVLFAICWLP 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530396836 255 FHITKtayLAVRSTPGVPCTvleAFAAAYKGTRPFAS-ANSVLDPILFYFTQKKFRRR 311
Cdd:cd15095  236 NHVLN---LWQRFDPNFPET---YATYALKIAALCLSyANSAVNPFVYAFMGENFRKY 287
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
32-236 1.99e-20

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 89.34  E-value: 1.99e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYA--C----SLPLLIYNYaqgdhWPFGDFACRLVRFL 105
Cdd:cd15392    6 MYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAvfCvpfsFIALLILQY-----WPFGEFMCPVVNYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 106 FYANLHGSILFLTCISFQRYLGICHPLAPwhkRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRN----RTVCYDLS 181
Cdd:cd15392   81 QAVSVFVSAFTLVAISIDRYVAIMWPLRP---RMTKRQALLLIAVIWIFALATALPIAITSRLFEDSNascgQYICTESW 157
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530396836 182 PPALATHYmpYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEpvAQERRGK 236
Cdd:cd15392  158 PSDTNRYI--YSLVLMILQYFVPLAVLVFTYTRIGIVVWAKRTPGE--AENNRDQ 208
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
32-257 3.24e-20

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 88.82  E-value: 3.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPL-LIYNYAqgDHWPFGDFACRLVRFLFYAN 109
Cdd:cd15203    6 LYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLvSLPFtLIYTLT--KNWPFGSILCKLVPSLQGVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LHGSILFLTCISFQRYLGICHPLapwHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAAT------GIQRNRTVCYDLSPp 183
Cdd:cd15203   84 IFVSTLTLTAIAIDRYQLIVYPT---RPRMSKRHALLIIALIWILSLLLSLPLAIFQELsdvpieILPYCGYFCTESWP- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 184 aLATHYMPYGMALTVIGFLLPFAALLACY----CLLACRLCRQDGPAEPVAQERRG------KAARMAVVVAAAFAISFL 253
Cdd:cd15203  160 -SSSSRLIYTISVLVLQFVIPLLIISFCYfrisLKLRKRVKKKRGKRTLSSRRRRSelrrkrRTNRLLIAMVVVFAVCWL 238

                 ....
gi 530396836 254 PFHI 257
Cdd:cd15203  239 PLNL 242
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
34-303 1.02e-19

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 87.15  E-value: 1.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  34 SAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGS 113
Cdd:cd14975    8 SLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATG-TWDFGLAACKGCVYVCAVSMYAS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 114 ILFLTCISFQRYLGICHP--LAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDlSPPALATHYmp 191
Cdd:cd14975   87 VFLITLMSLERFLAVSRPfvSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMCKYRHY-SDGQLVFHL-- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 192 ygMALTVIGFLLPFAALLACYCLLACRLCRqdgpaepVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAvrSTPGV 271
Cdd:cd14975  164 --LLETVVGFAVPFTAVVLCYSCLLRRLRR-------RRFRRRRRTGRLIASVVVAFAACWLPYHVGNLLEVV--SELIG 232
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 530396836 272 PCTVLEAFAAAYKGTRPFASA----NSVLDPILFYF 303
Cdd:cd14975  233 GSKMAGTLGKVAEAGRPIAGAlaflSSSINPLLYAF 268
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
28-212 1.24e-19

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 86.81  E-value: 1.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYnYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15185    2 FLPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIH-YVRWNNWVFGHGMCKLLSGFYY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALAT 187
Cdd:cd15185   81 LGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGI-ITSIITWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTED 159
                        170       180
                 ....*....|....*....|....*.
gi 530396836 188 HYMPY-GMALTVIGFLLPFAALLACY 212
Cdd:cd15185  160 SWKRFhALRMNIFGLALPLLIMVICY 185
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
32-212 1.69e-19

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 86.18  E-value: 1.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQgDHWPFGDFACRLVRFLFYANL 110
Cdd:cd15001    5 VYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVfCVPLKTAEYFS-PTWSLGAFLCKAVAYLQLLSF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPL-APWHKRGGRraAWLVCVAVWLAVTTQCLPTAifAATGIQRNRTVCYDLSP---PALA 186
Cdd:cd15001   84 ICSVLTLTAISIERYYVILHPMkAKSFCTIGR--ARKVALLIWILSAILASPVL--FGQGLVRYESENGVTVYhcqKAWP 159
                        170       180
                 ....*....|....*....|....*...
gi 530396836 187 THYMP--YGMALTVIGFLLPFAALLACY 212
Cdd:cd15001  160 STLYSrlYVVYLAIVIFFIPLIVMTFAY 187
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
44-234 1.92e-19

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 86.56  E-value: 1.92e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYA-CSLPLLI-YNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCIS 121
Cdd:cd15204   18 NLLLIAVLARYKKLRTLTNLLIANLALSDFLVAvFCLPFEMdYYVVRQRSWTHGDVLCAVVNYLRTVSLYVSTNALLVIA 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 122 FQRYLGICHPLAPwhkRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQ--RNRTVCYDLSPPALATHYMPYGMALTVI 199
Cdd:cd15204   98 IDRYLVIVHPLKP---RMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYanQGKIFCGQIWPVDQQAYYKAYYLFLFVL 174
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 530396836 200 GFLLPFAALLACYCLLACRLCRQDGPAEPVAQERR 234
Cdd:cd15204  175 EFVLPVLIMTLCYLRIVRKVWFRRVPGQQTEQIRR 209
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
32-221 4.41e-19

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 85.53  E-value: 4.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPL-LIYNYAQgdHWPFGDFACRLVRFLFYAN 109
Cdd:cd15195    6 VTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFfNMPMdAVWNYTV--EWLAGDLMCRVMMFLKQFG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LHGSILFLTCISFQRYLGICHPLApwHKRGGRRAAWLVCVAvWLAVTTQCLPTAIFAATGI----QRNRTVCYDLSPPAL 185
Cdd:cd15195   84 MYLSSFMLVVIALDRVFAILSPLS--ANQARKRVKIMLTVA-WVLSALCSIPQSFIFSVLRkmpeQPGFHQCVDFGSAPT 160
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 530396836 186 ATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCR 221
Cdd:cd15195  161 KKQERLYYFFTMILSFVIPLIITVTCYLLILFEISK 196
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
29-220 5.26e-19

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 85.20  E-value: 5.26e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  29 LPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdhWPFGDFACRLVRFLFYA 108
Cdd:cd15175    3 LPAMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASAAKK--WVFGEEMCKAVYCLYKM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 109 NLHGSILFLTCISFQRYLGICHplAPWHKRGGRRAAW---LVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCyDLSPPAL 185
Cdd:cd15175   81 SFFSGMLLLMCISIDRYFAIVQ--AASAHRHRSRAVFiskVSSLGVWVLAFILSIPELLYSGVNNNDGNGTC-SIFTNNK 157
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 530396836 186 ATHYMPYGMALTVIGFLLPFAALLACYCLLACRLC 220
Cdd:cd15175  158 QTLSVKIQISQMVLGFLVPLVVMSFCYSVIIKTLL 192
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
27-310 5.49e-19

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 85.42  E-value: 5.49e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYA--CsLPLLIYNYAQGDhWPFGDFACRLVRF 104
Cdd:cd15096    1 IVVPVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVvfC-VPFTATDYVLPT-WPFGDVWCKIVQY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 105 LFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVaVWLAVTTQCLPTA----IFAATGIQRNRTVCYDL 180
Cdd:cd15096   79 LVYVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVG-IWIVILVANIPVLflhgVVSYGFSSEAYSYCTFL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 181 SPPALATHYmpYGMALTVIGFLLPFAALLACYCLLACRLCRQDGP-AEPVAQERRGKAARMAVVVAAAFA--ISFLPFHI 257
Cdd:cd15096  158 TEVGTAAQT--FFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPgGRRSAESQRGKRRVTRLVVVVVVVfaICWLPIHI 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530396836 258 tktaYLAVRSTPGVPCTVLeafaaaYKGTRP----FASANSVLDPILFYFTQKKFRR 310
Cdd:cd15096  236 ----ILLLKYYGVLPETVL------YVVIQIlsncLAYGNSCVNPILYAFLSQNFRK 282
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
28-310 6.91e-19

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 84.92  E-value: 6.91e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIyNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15183    2 LLPPLYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWI-DYKLKDDWIFGDAMCKFLSGFYY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALAT 187
Cdd:cd15183   81 LGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGI-ITSIITWALAILASMPCLYFFKSQWEFTHHTCSAHFPRKSLI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 188 HYMPY-GMALTVIGFLLPFAALLACYCLLACRLCRQdgpaepvAQERRGKAARMAVVVAAAFAISFLPFHITK--TAYLA 264
Cdd:cd15183  160 RWKRFqALKLNLLGLILPLLVMIICYTGIINILLRR-------PNEKKAKAVRLIFVITLLFFLLWTPYNLAAfvSAFQD 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 530396836 265 VRSTPgvPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15183  233 VLFTP--SCEQSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFRK 276
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
32-310 1.25e-18

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 84.71  E-value: 1.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNicVITQICTSRRALTRTAV--YTLNLALADLLY-ACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYA 108
Cdd:cd14979    6 IYVAIFVVGIVGN--LLTCIVIARHKSLRTTTnyYLFSLAVSDLLIlLVGLPVELYNFWWQYPWAFGDGGCKLYYFLFEA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 109 NLHGSILFLTCISFQRYLGICHPLApwHKR-GGRRAAWLVCVAVWLAVTTQCLPtaIFAATGIQ----------RNRTVC 177
Cdd:cd14979   84 CTYATVLTIVALSVERYVAICHPLK--AKTlVTKRRVKRFILAIWLVSILCAIP--ILFLMGIQylngplpgpvPDSAVC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 178 ydlSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAE------------PVAQERRGKAARMAVVVA 245
Cdd:cd14979  160 ---TLVVDRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSMRNIKKgtraqgtrnvelSLSQQARRQVVKMLGAVV 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530396836 246 AAFAISFLPFHITKTAYLAVrSTPGVPCTVleAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd14979  237 IAFFVCWLPFHAQRLMFSYA-SKEDTFLFD--FYQYLYPISGILFYLSSAINPILYNLMSSRFRV 298
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
32-310 1.60e-18

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 83.71  E-value: 1.60e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDhWPFGDFACRLVRFLFYANLH 111
Cdd:cd15121    6 ILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGG-WEFGSVVCKLCHYVCGVSMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRGgRRAAWLVCVAVWLAVTTQCLPTAIF-AATGIQRNRTVC--YDLSPPALATH 188
Cdd:cd15121   85 ASIFLITLMSMDRCLAVAKPFLSQKMRT-KRSVRALLLAIWIVAFLLSLPMPFYrTVLKKNINMKLCipYHPSVGHEAFQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMpygmALTVIGFLLPFAALLACYCLLACRLcrqdgpaEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLA-VRS 267
Cdd:cd15121  164 YL----FETITGFLLPFTAIVTCYSTIGRRL-------RSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAgALQ 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 530396836 268 TPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15121  233 NQAGNASVLKAAKLARPNVTALAFLSSSVNPVLYAFAGGSLIR 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
32-310 2.32e-18

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 83.00  E-value: 2.32e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYA-CSLPLLIYNYAQGdHWPFGDFACRLVRFLFYANL 110
Cdd:cd14967    5 FLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVAlLVMPFSAVYTLLG-YWPFGPVLCRFWIALDVLCC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCvAVWLAVTTQCLPTAIFAatgiqRNRTVCYDLSPPALATHYM 190
Cdd:cd14967   84 TASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIA-AVWVYSLLISLPPLVGW-----RDETQPSVVDCECEFTPNK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 191 PYGMALTVIGFLLPFAALLACYCLLACrlcrqdgpaepVAQERRgKAARMAVVVAAAFAISFLPFHITktaYLaVRSTPG 270
Cdd:cd14967  158 IYVLVSSVISFFIPLLIMIVLYARIFR-----------VARREL-KAAKTLAIIVGAFLLCWLPFFII---YL-VSAFCP 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 530396836 271 VPCTVLEAFAAAYKgtrpFASANSVLDPILFYFTQKKFRR 310
Cdd:cd14967  222 PDCVPPILYAVFFW----LGYLNSALNPIIYALFNRDFRR 257
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
32-219 2.33e-18

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 83.38  E-value: 2.33e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15092    6 VYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLG-FWPFGNALCKTVIAIDYYNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMP 191
Cdd:cd15092   85 TSTFTLTAMSVDRYVAICHPIKALDVRTPHKAK-VVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVEIPTPQDYWDPV 163
                        170       180
                 ....*....|....*....|....*...
gi 530396836 192 YGMALTVIGFLLPFAALLACYCLLACRL 219
Cdd:cd15092  164 FGICVFLFSFIIPVLIISVCYSLMIRRL 191
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
27-310 3.26e-18

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 83.00  E-value: 3.26e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICT-SRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFL 105
Cdd:cd15925    1 ILVALAYGLVCAIGLLGNLAVMYLLRNcARRAPPPIDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 106 FYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWlVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPA- 184
Cdd:cd15925   81 TVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKI-ITLALWAAALLATVPTAIFATEGEVCGVELCLLKFPSNy 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 -LAThympYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEpvAQERRGKAARMAVVVAAAFAISFLPFHITkTAYL 263
Cdd:cd15925  160 wLGA----YHLQRVVVAFVVPLGVITTSYLLLLSFLQQHKVNQN--NRQRQSVIARSVRLVVASFFLCWFPNHVV-TFWG 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 264 AVRSTPGVPCTVLEAFAAAY--KGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15925  233 VLVKFRAVPWNSTFYFIHTYvfPVTTCLAHSNSCLNPVLYCLMRREFRQ 281
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
27-311 5.02e-18

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 82.50  E-value: 5.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNiCVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15924    1 QLFPVLYTVIFFAGILLN-GLAMWIFFHIPSKSSFIIYLKNTVVADLLMILTFPFKILSDAGLGPWQLRTFVCRVTSVLF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLapWHKRGGRRA-AWLVCVAVWLAVTTQCLPTAIFaATGIQRNRTV--CYDL-SP 182
Cdd:cd15924   80 YFTMYTSIVFLGLISIDRYLKIVRPF--KTSFPKSVSfAKILSVVVWALMFLLSLPNMIL-TNQQPREKNVkkCSFLkSE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 183 PALATHYMP--YGMALTVIGFLLpfaaLLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKT 260
Cdd:cd15924  157 LGLKWHEIVnyICQVIFWIVFLL----MIVCYTAITKKVYRSYRRVFRSSSSRRKKSNVKIFIIVAVFFVCFVPYHFARI 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530396836 261 AYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15924  233 PYTLSQTRDVFDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRES 283
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
32-212 5.90e-18

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 82.10  E-value: 5.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQ-ICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNyAQGDHWPFGDFACRLVRFLFYANL 110
Cdd:cd14983    6 VYVLTILLGLPSNLLALYAfVNRARLRLTPNVIYMINLCLSDLVFILSLPIKIVE-ALSSAWTLPAVLCPLYNLAHFSTL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQR-------NRTVCYDLSPP 183
Cdd:cd14983   85 YASTCFLTAISAGRYLGVAFPIK-YQLYKKPLYSCLVCVAIWALVIFHVTLVFILETSGGTLdintpvgNSSTCYENFTP 163
                        170       180
                 ....*....|....*....|....*....
gi 530396836 184 ALATHYMPYGMALTVIGFLLPFAALLACY 212
Cdd:cd14983  164 EQLALLAPVRLELSLVLFFLPLAITAFCY 192
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
27-223 6.06e-18

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 82.39  E-value: 6.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQgDHWPFGDFACRLVRFL 105
Cdd:cd15389    1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLlNTPFTLVRFVN-STWVFGKIMCHLSRFA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 106 FYANLHGSILFLTCISFQRYLGICHPLAPwhkRGGRRAAWLVCVAVWLAVTTQCLPTAIFAA-----TGIQRNRTVCYDL 180
Cdd:cd15389   80 QYCSVYVSTLTLTAIALDRHRVILHPLKP---RITPCQGVVVIAIIWIMASCLSLPHAIYQKlvefeYSNERTRSRCLPS 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 530396836 181 SPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQD 223
Cdd:cd15389  157 FPEPSDLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLWLRN 199
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
28-310 9.26e-18

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 81.78  E-value: 9.26e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15202    2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPwhkRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRN-----RTVCYDLSP 182
Cdd:cd15202   82 CSVHVSAYTLTAIAVDRYQAIMHPLKP---RISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYsedivRSLCLEDWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 183 PALATHYMPYGMALTVIGFLLPFAALLACYCLLACRL--CRQDGPAEPVAQER----RGKAARMAVVVAAAFAISFLPFH 256
Cdd:cd15202  159 ERADLFWKYYDLALFILQYFLPLLVISFAYARVGIKLwaSNMPGDATTERYFAlrrkKKKVIKMLMVVVVLFALCWLPFN 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530396836 257 ItktaYLAVRSTPgvPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15202  239 I----YVLLLSSK--PDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFRI 286
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
32-310 9.50e-18

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 81.87  E-value: 9.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLVRFLFYANL 110
Cdd:cd14969    6 YLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVvGYPLSFYSNLSG-RWSFGDPGCVIYGFAVTFLG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLAPWHKRggRRAAWLVCVAVWLavttQCLPTAIF-----AATGIQRNRTVC----YDLS 181
Cdd:cd14969   85 LVSISTLAALAFERYLVIVRPLKAFRLS--KRRALILIAFIWL----YGLFWALPplfgwSSYVPEGGGTSCsvdwYSKD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 182 PPALAthympYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMA-VVVAAAFAISFLPFHITKT 260
Cdd:cd14969  159 PNSLS-----YIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKKAeKKVAKMVLVMIVAFLIAWT 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530396836 261 AYLAVrstpgvpctvleAFAAAYKGTRP-----------FASANSVLDPILFYFTQKKFRR 310
Cdd:cd14969  234 PYAVV------------SLYVSFGGESTippllatipalFAKSSTIYNPIIYVFMNKQFRR 282
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
28-218 4.97e-17

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 79.80  E-value: 4.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAqgDHWPFGDFACRLVRFLFY 107
Cdd:cd15184    2 LLPPLYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAA--NEWVFGNAMCKLLTGLYH 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALAT 187
Cdd:cd15184   80 IGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGV-VTSVVTWVVAVFASLPGIIFTKSQKEGSHYTCSPHFPPSQYQ 158
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530396836 188 HYMPY-GMALTVIGFLLPFAALLACY-----CLLACR 218
Cdd:cd15184  159 FWKNFqTLKMNILGLVLPLLVMIICYsgilkTLLRCR 195
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
33-310 6.52e-17

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 79.35  E-value: 6.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHG 112
Cdd:cd15148    7 YSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNNQWTLGPLLCKVVGNLFYMNMYI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 113 SILFLTCISFQRYLGIchplapwhKRGGRRAAWL-------VCVAVWlAVTTQCLPTAIFAATGiQRNRTVCYDLS--PP 183
Cdd:cd15148   87 SIILLGFISLDRYLKI--------NRSSRRQKFLtrkwsivACGVLW-AVALVGFVPMIVLTEK-NEESTKCFQYKdrKN 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 184 ALATHYMPYgmaLTVIGFLLPFAALLACYCLLACRLCR--QDGPAEPVAQeRRGKAARMAVVVAAAFAISFLPFHITKTA 261
Cdd:cd15148  157 AKGKAIFNF---LIVAMFWLVFLLLILSYGKIAKKLLRisRDKPDFPNAA-KYNRTARKSFFVLFIFTVCFVPYHAFRIF 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 262 YLAVRSTPgVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15148  233 YITSQLQN-NSCYWKEILHKTNEIMLLLSAFNSCLDPVMYFLLSSSIRK 280
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
33-219 6.53e-17

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 79.59  E-value: 6.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHG 112
Cdd:cd16003    7 YGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 113 SILFLTCISFQRYLGICHPLAPwhkRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMpY 192
Cdd:cd16003   87 SIYSMTAIAVDRYMAIIDPLKP---RLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVAWPGGPDQHFT-Y 162
                        170       180
                 ....*....|....*....|....*..
gi 530396836 193 GMALTVIGFLLPFAALLACYCLLACRL 219
Cdd:cd16003  163 HIIVIVLVYCLPLLVMGITYTIVGITL 189
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
66-309 9.52e-17

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 79.06  E-value: 9.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  66 LNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAw 145
Cdd:cd15120   39 LHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWAS- 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 146 LVCVAVWLAVTTQCLPTAIFAATGIQRN-RTVC---YDLSPPALATHYMPYGMALTV--------IGFLLPFAALLACYC 213
Cdd:cd15120  118 AIVLGVWISAILLSIPYLAFRETRLDEKgKTICqnnYALSTNWESAEVQASRQWIHVamfvfrflLGFLLPFLIITFCYV 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 214 LLACRLcRQDGPAepvaqeRRGKAARMAVVVAAAFAISFLPFHItktaYLAVRSTPGVPCTVLEAFAAAYKGTRPFasaN 293
Cdd:cd15120  198 RMALKM-KERGLA------RSSKPFKVMFTAVVSFFVCWLPYHL----HSGLVLTRGRPPSLTDITLLLTVGTTCF---N 263
                        250
                 ....*....|....*.
gi 530396836 294 SVLDPILFYFTQKKFR 309
Cdd:cd15120  264 TCFTPVLYLFVGENFK 279
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
27-309 1.10e-16

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 78.30  E-value: 1.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDhwpfGDFACRLVR-FL 105
Cdd:cd15163    1 LALMVINTLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLPTRIVMYYSAG----NCLTCSFVHiFS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 106 FYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWL---AVTTQCLPTAIfaatgiqrnrtvcydlsp 182
Cdd:cd15163   77 YFVNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAK-GICVFIWLfaiVVTFSILTTAI------------------ 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 183 pALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEpvAQERRGKAARMAVVVAAAFAISFLPFHITKTAy 262
Cdd:cd15163  138 -KFASCCLSKLFALTVFEFFLPLLIITFFTIRIMCALSRPGLMHQ--SRERRMRAVQLLITVLIIFMICFTPFHVRQVA- 213
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 263 LAVRSTPGVPCTVLeafaaAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15163  214 VAFNPDIPHHTSLI-----VYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
32-266 1.15e-16

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 78.69  E-value: 1.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15928    6 VCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCTY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTV-CYDLSPPALATHYM 190
Cdd:cd15928   86 ASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPrGFECTVVNVSSGLL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 191 PYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISF----LPFHITKTAYLAVR 266
Cdd:cd15928  166 SVMLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRTAGASRRDNNHRQTVRMLAVIVLAFvlcwLPFHVGRVIFNHSR 245
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
27-218 1.30e-16

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 78.34  E-value: 1.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQgdHWPFGDFACRLVRFLF 106
Cdd:cd15186    1 IFLSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLIN--EWGLHNAMCKLTTAFF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCvAVWLAVTTQCLPTAIFAatgiQRNRTVCYDLSPPALA 186
Cdd:cd15186   79 FIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISL-GVWAAAILVAVPQFMFT----KMKENECLGDYPEVLQ 153
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 530396836 187 THYMPY-GMALTVIGFLLPFAALLACYC-----LLACR 218
Cdd:cd15186  154 EIWPVLrNVELNFLGFLLPLLIMSYCYFriiqtLFSCK 191
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
32-310 1.71e-16

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 78.53  E-value: 1.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACS-LPLLIYNYAQGDHWPFGDFACRLVRFLFYANL 110
Cdd:cd15134    6 IYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILgLPFELYTIWQQYPWVFGEVFCKLRAFLSEMSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLAPwHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFaaTGIQrnrtvcYDLSPP------- 183
Cdd:cd15134   86 YASVLTITAFSVERYLAICHPLRS-HTMSKLSRAIRIIIAIWIIAFVCALPFAIQ--TRIV------YLEYPPtsgeale 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 184 -----ALATHYMPYGMAL---TVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFA------ 249
Cdd:cd15134  157 esafcAMLNEIPPITPVFqlsTFLFFIIPMIAIIVLYVLIGLQLRRSTLLRRGQRSVSGGRRSSQSRRTVLRMLvavvva 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530396836 250 --ISFLPFHITKTAYLAvrsTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15134  237 ffICWAPFHAQRLLTVY---AKNMTPPYLFINRILFYISGVLYYVSSTVNPILYNVMSAKYRQ 296
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
28-310 2.07e-16

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 78.08  E-value: 2.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLL-YACSLPLLIYNYAQgDHWPFGDFACRLVRFLF 106
Cdd:cd15927    2 VVPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLlLLTCVPFTSTIYTL-DSWPFGEFLCKLSEFLK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLapwhKRGGRRAAWLVCV---AVWLAVTTQCLPTAIFAAT-----GIQRNRTVCY 178
Cdd:cd15927   81 DTSIGVSVFTLTALSADRYFAIVNPM----RKHRSQATRRTLVtaaSIWIVSILLAIPEAIFSHVvtftlTDNQTIQICY 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 179 DLsPPALATHYmPYGMALT--VIGFLLPFAALLACYCLLACRL---CRQDGPAEPVAQER----RGKAARMAVVVAAAFA 249
Cdd:cd15927  157 PY-PQELGPNY-PKIMVLLrfLVYYLIPLLIIGVFYVLMARHLirsTRNIGSGQNQAAQRqieaRKKVAKTVLAFVVLFA 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530396836 250 ISFLPFHItktaYLAVRSTPGVPCTVLEAFAAAYKGT-RPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15927  235 VCWLPRHV----FMLWFHFAPNGLVDYNAFWHVLKIVgFCLSFINSCVNPVALYLLSGSFRR 292
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
29-311 2.26e-16

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 77.89  E-value: 2.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  29 LPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYA 108
Cdd:cd15200    3 LAPVLGIEFVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIDYYLRNEVWRFGATACQVNLFMLSM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 109 NLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWlVCVAVWLAVTTqcLPTAIFAATGIQRNRTvCYDLSPPALATH 188
Cdd:cd15200   83 NRTASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAK-VAAGLWILILL--LNIHLLLLDHVQSNST-CLSYDHGTDPSA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMPYGMALTVIGFLLPFAALLacYCLLACRL-CRQDGPAEpvaQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRS 267
Cdd:cd15200  159 SDRWHRILFFLEFFLPLGIIL--FCIFSIILtLKQRKLAK---QAGPQRAVKVLAVIVLVYTVCFLPSILFALASLVAFK 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 530396836 268 TPGvpCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15200  234 VSQ--CRSLDLCTQLFHGSLAFTYLNSALDPVLYCFSSPSFLNQ 275
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
27-310 4.67e-16

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 77.16  E-value: 4.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLN---ICVITQIctsrRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVR 103
Cdd:cd15150    1 VIFPLLYTVLFIVGLTMNglaMRVFFQI----PSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGSWPLRGFVCQVTS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 104 FLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAA-TGIQRNRTVCYDL-S 181
Cdd:cd15150   77 VIFYFTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAK-ILSTVIWASMFALSLPNMILTNrQPTPKNVKKCSLLkS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 182 PPALATHYMPYGMALTVigFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTA 261
Cdd:cd15150  156 EFGLVWHEIVNYICQVI--FWVNFLIVIVCYTLITKELYKSYKRTRGVGKVSRKKVNVKVFIIIAVFFICFVPFHFARIP 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 262 YLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15150  234 YTLSQTRDVFDCTAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRN 282
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
33-311 1.15e-15

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 75.63  E-value: 1.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQI-CTSRRALTRTaVYTLNLALADLLYACSLPLLIYNYAQgDHWPFGDFACRLVRFL--FYAN 109
Cdd:cd15166    7 YSFIFIIGLFVNITALWVFsCTTKKRTTVT-VYMMNVALVDLIFILSLPFRMVYYAK-DEWPFGDYFCRILGALtvFYPS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LhgSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAATGIQ-RNRTVCYDLSPPALATH 188
Cdd:cd15166   85 I--ALWLLAFISADRYMAIVQPKHAKELKNTPKAV-LACVGVWIMTLASTFPLLFLYEDPDKaSNFTTCLKMLDIIHLKE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMPYGMALTVIGFLLPFAALLACYCLLACRLCR-QDGPAEPVAQERRGKaarMAVVVAAAFAISFLPFHItktaylavrs 267
Cdd:cd15166  162 VNVLNFTRLIFFFLIPLFIMIGCYLVIIHNLVHgRTSKLKPKVKEKSIR---IIITLIVQVLVCFVPFHI---------- 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530396836 268 tpgvpCTVLEAFAAAYKGTRPFA-------SANSVLDPILFYFTQKKFRRR 311
Cdd:cd15166  229 -----CFAFLMLQNGDNSYNPWAafttflmNLSTCLDVILYYIVSKQFQAR 274
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
27-310 2.01e-15

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 75.22  E-value: 2.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYnyAQGDHWPFgdFACRLVRFLF 106
Cdd:cd15920    1 VTLPVMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRVA--YQNTAGPL--SFCKIVGAFF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPL-------APWhkrgGRRAAWLvcvaVWLAVTTQCLPTAIFAatgiqRNRTVCYD 179
Cdd:cd15920   77 YLNMYASILFLSLISLDRYLKIIKPLqqfkihtVPW----SSAASGG----VWLLLLACMIPFLFES-----RNEGPCDN 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 180 lsppaLATHYMPYGMA------LTVIGFLLPFAALLACYCLLACRLCR-QDGPAEPVAQERRGKAARMAVVVAAAFAISF 252
Cdd:cd15920  144 -----KCFHFRSKGLTagginlTAVVIFYILSLLFLYFYAKISHKLYKvSLGNAQQQIKKASKRAIIKTFIVLAIFIVCF 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530396836 253 LPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15920  219 VPYHIVRVPYVLAQIDVISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRR 276
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
32-217 2.27e-15

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 74.58  E-value: 2.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC--SLPLLIYN---YAQGdhwpfGDFACRLVRFLF 106
Cdd:cd15196    6 VLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALfnVLPQLIWDityRFYG-----GDLLCRLVKYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLApWHKRGGRRAAWLVCVAvWLAVTTQCLPTA-IFAATGIQRNRTVCY-DLSPPA 184
Cdd:cd15196   81 VVGMYASSYVLVATAIDRYIAICHPLS-SHRWTSRRVHLMVAIA-WVLSLLLSIPQLfIFSYQEVGSGVYDCWaTFEPPW 158
                        170       180       190
                 ....*....|....*....|....*....|...
gi 530396836 185 LATHYMPYgmaLTVIGFLLPFAALLACYCLLAC 217
Cdd:cd15196  159 GLRAYITW---FTVAVFVVPLIILAFCYGRICY 188
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
33-227 3.02e-15

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 74.88  E-value: 3.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHG 112
Cdd:cd16004    7 YSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 113 SILFLTCISFQRYLGICHPLAPWHKRGGRRAawlVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPAL-ATHYMP 191
Cdd:cd16004   87 SIYSMTAIAADRYMAIIHPFKPRLSAGSTKV---VIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAWPGDSgGKHQLT 163
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 530396836 192 YGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAE 227
Cdd:cd16004  164 YHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGH 199
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
27-311 5.05e-15

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 74.05  E-value: 5.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNIcVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15151    1 VVFPVLYTVLFLVGLILNS-VAAWIFFHIPSTSTFIVYLKNTLVADLIMTLMLPFKILSDSGLGPWQLRAFVCRFSAVVF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQ-RNRTVCYDLSPPAL 185
Cdd:cd15151   80 YITMYISIILLGLISFDRYLKIVRPFGKSWVQ-RVRFAKILSGAVWLVMFLLSVPNMILSNKPATpISVKKCASLKSPLG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 186 ATHYMPYGMALTVIgFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAV 265
Cdd:cd15151  159 LKWHEVVNYICQFI-FWGVFALMVLFYTIISKKVYESYKKSRSKDNKASKKTKAKVFIIVAVFFVCFAPFHFVRVPYTLS 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 530396836 266 RSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15151  238 QTGKITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQR 283
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
53-309 5.06e-15

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 74.03  E-value: 5.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  53 TSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPL 132
Cdd:cd15167   27 QKRSSRKCINIYLINLLTADFLLTLALPVKIAVDLGIAPWKLKIFHCQVTACLIYINMYLSIIFLGFVSIDRYLQLTHSS 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 133 ApWHKRGGRRAAWLVCVAVWLAVTTQCLPT-AIFAATGIQRNRTVCYDLSPpALATHYMPYGMALTVIGFLLPFAALLAC 211
Cdd:cd15167  107 K-LYRIQEPGFAKMISAVVWTLVLFIMVPNmAIPIKTIEEKPGVGCADFKT-EFGRHWHVLTNFICMAIFLNFSAIILIS 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 212 YCLLACRLCRQDGPAEpvaQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFAS 291
Cdd:cd15167  185 NFLVIRKLYRNKDSEE---YRNARQALVNILLVTAGYVICFVPYHIVRIPYTLSQSEVITDCSLKRSLFLAKESTLLLAV 261
                        250
                 ....*....|....*...
gi 530396836 292 ANSVLDPILFYFTQKKFR 309
Cdd:cd15167  262 LNLCFDPILYFHLSKAFR 279
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
33-310 6.99e-15

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 73.63  E-value: 6.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYA--CSLPLLIYNYAQgdHWPFGDFACRLVRFLFYANL 110
Cdd:cd15012    6 YTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGifCVLQNLSIYLIP--SWPFGEVLCRMYQFVHSLSY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLapWHKRGGRRAA-WLVCVAVWLAVTTQCLPTAIFAAT--GIQRNRTVCYDLSPPALAT 187
Cdd:cd15012   84 TASIGILVVISVERYIAILHPL--RCKQLLTAARlRVTIVTVWLTSAVYNTPYFVFSQTveILVTQDGQEEEICVLDREM 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 188 HYMP-YGMALTVIGFLLPFAALLACYCLLACRLCRQDgpaepvAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVR 266
Cdd:cd15012  162 FNSKlYDTINFIVWYLIPLLIMTVLYSKISIVLWKSS------SIEARRKVVRLLVAVVVSFALCNLPYHARKMWQYWSE 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 530396836 267 STPGVPC--TVLEAFaaaykgTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15012  236 PYRCDSNwnALLTPL------TFLVLYFNSAVNPLLYAFLSKRFRQ 275
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
33-170 1.06e-14

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 74.28  E-value: 1.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITqICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNyaQGDHWPFGDFACRLVRFLFYANLHG 112
Cdd:PHA02638 105 YIIIFILGLFGNAAIIM-ILFCKKIKTITDIYIFNLAISDLIFVIDFPFIIYN--EFDQWIFGDFMCKVISASYYIGFFS 181
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530396836 113 SILFLTCISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTA-IFAATGI 170
Cdd:PHA02638 182 NMFLITLMSIDRYFAILYPIS-FQKYRTFNIGIILCIISWILSLIITSPAYfIFEASNI 239
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
44-212 1.12e-14

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 73.23  E-value: 1.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACS--LPLLIYNYAQgdHWPFGDFACRLVRFLFYANLHGSILFLTCIS 121
Cdd:cd15197   18 NSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLInvLTDIIWRITV--EWRAGDFACKVIRYLQVVVTYASTYVLVALS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 122 FQRYLGICHPLApwHKRGGRRAAWLVCVAvWLAVTTQCLPTAI-FAATGIQRNRTVCYDLSPPalATHYMPYGMALTVIG 200
Cdd:cd15197   96 IDRYDAICHPMN--FSQSGRQARVLICVA-WILSALFSIPMLIiFEKTGLSNGEVQCWILWPE--PWYWKVYMTIVAFLV 170
                        170
                 ....*....|..
gi 530396836 201 FLLPFAALLACY 212
Cdd:cd15197  171 FFIPATIISICY 182
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
28-257 1.95e-14

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 72.46  E-value: 1.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLY-ACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15394    2 LIIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMcATCVPLTLAYAFEPRGWVFGRFMCYFVFLMQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLapwHKRGGRRAAWLVCVAVWLAVTTQCLPTAI--FAATGIQRNRTVCYDLSPpA 184
Cdd:cd15394   82 PVTVYVSVFTLTAIAVDRYYVTVYPL---RRRISRRTCAYIVAAIWLLSCGLALPAAAhtYYVEFKGLDFSICEEFWF-G 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530396836 185 LATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGP--AEPVAQE----RRGKAARMAVVVAAAFAISFLPFHI 257
Cdd:cd15394  158 QEKQRLAYACSTLLITYVLPLLAISLSYLRISVKLRNRVVPgsMTQSQAEwdraRRRKTFRLLVVVVVAFAICWLPLHI 236
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
27-311 2.14e-14

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 72.13  E-value: 2.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNiCVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15969    1 IVFPVLYLIIFIGSILLN-GLAVWIFFHIRNKTSFIFYLKNIVIADLLMTLTFPFKIIQDSGLGPWNFNFFLCRYTSVLF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLApwHKRGGR-RAAWLVCVAVWLAVTTQCLPTAIFA-ATGIQRNRTVCYDLSPPA 184
Cdd:cd15969   80 YASMYTSIVFLGLISLDRYLKVVKPFG--DSRMYSiTFTKVLSACVWLIMAFLSLPNIILTnGQPTEDNIHDCSKLKSPL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 LATHYMPYGMALTVIgFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKaARMAVVVAAAFAISFLPFHITKTAYLA 264
Cdd:cd15969  158 GVKWHTAVSYINICI-FVAVLVILIVCYISISRYIYKSSKQFISSSSRTRKH-NQSIRVVVAVFFVCFLPYHLCRIPFTF 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 265 VRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15969  236 SQLDKILDCTIKTILYYCKEATLFLSACNVCLDPIIYFFMCRSFSQR 282
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
59-311 2.92e-14

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 71.76  E-value: 2.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  59 TRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKR 138
Cdd:cd15118   32 TVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFFLNMFVSGFLLAAISLDRCLLVVKPVWAQNHR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 139 gGRRAAWLVCVAVWLAVTTQCLPTAIFAAT-GIQRNRTVCY------DLSPPALATH--YMPYGMALT--VIGFLLPFAA 207
Cdd:cd15118  112 -NVAAAKKICGVIWAMALINTIPYFVFRDViERKDGRKLCYynfalfSPSPDNNHPIckQRQEGLAISklLLAFLIPLVI 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 208 LLACYCLLACRLcRQDGpaepvaQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFaaaykgtr 287
Cdd:cd15118  191 IAVSYAVVSLII-RHRC------RRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEVMAHNQHSLRPLVIQGL-------- 255
                        250       260
                 ....*....|....*....|....*...
gi 530396836 288 PFASA----NSVLDPILFYFTQKKFRRR 311
Cdd:cd15118  256 PFATTlaflNSVLNPVLYVFSCPDFCNK 283
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
32-221 3.82e-14

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 71.75  E-value: 3.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC--SLPLLIYNYAQGDHWPfgDFACRLVRFLFYAN 109
Cdd:cd15386    6 VLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfqVLPQLIWEITYRFQGP--DLLCRAVKYLQVLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LHGSILFLTCISFQRYLGICHPLAPWHKRGgrRAAWLVCVAVWLAVTTQCLPTA-IFAATGIQRNRTVcYDlsppALATH 188
Cdd:cd15386   84 MFASTYMLIMMTVDRYIAVCHPLRTLQQPS--RQAYLMIGATWLLSCILSLPQVfIFSLREVDQGSGV-LD----CWADF 156
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 530396836 189 YMPYGMA-----LTVIGFLLPFAALLACYCLLACRLCR 221
Cdd:cd15386  157 GFPWGAKayitwTTLSIFVLPVAILIVCYSLICYEICK 194
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
32-236 7.60e-14

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 70.87  E-value: 7.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd14986    6 VLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLapwHKRGGRRAAWLVCVAVWLAVTTQCLPTA-IFAATGIQRNRTVCYDLSPPalATHYM 190
Cdd:cd14986   86 ASTYILVSMSLDRYQAIVKPM---SSLKPRKRARLMIVVAWVLSFLFSIPQLvIFVERELGDGVHQCWSSFYT--PWQRK 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 530396836 191 PYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGK 236
Cdd:cd14986  161 VYITWLATYVFVIPLIILSYCYGRILRTIWIRSRQKTDRPIAPTAM 206
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
32-310 1.42e-13

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 69.76  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGDhWPFGDFACRLVRFLFYANL 110
Cdd:cd14977    6 LSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLlCVPLNAYNLLTKD-WLFGDVMCKLVPFIQVTSL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLaPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQR-----NRTVC-YDLSPPA 184
Cdd:cd14977   85 GVTVFSLCALSIDRYRAAVNSM-PMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVARESsldnsSLTVCiMKPSTPF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 LATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCR-----QDGPAEPVAQERRgkAARMAVVVAAAFAISFLPFHITk 259
Cdd:cd14977  164 AETYPKARSWWLFGCYFCLPLAFTAVCYLLMARTLIRaakeyTRGTKKHMKQRRQ--LAKTVLCLVLVFAFCWLPEHIS- 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530396836 260 TAYLAVRSTPGVPCTVLEAFAAAYKGtRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd14977  241 NILRATLYNEVLIDTRSTLDILDLIG-QFLSFFNSCVNPIALYLLSEPFRR 290
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
35-221 2.30e-13

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 68.83  E-value: 2.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  35 AVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGS 113
Cdd:cd15210    9 VFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAfNLPLAASTFLHQ-AWIHGETLCRVFPLLRYGLVAVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 114 ILFLTCISFQRYLGICHPlAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHymPYG 193
Cdd:cd15210   88 LLTLVLITLNRYILIAHP-SLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGIWGRFGLDPKVCSCSILRDKKGR--SPK 164
                        170       180
                 ....*....|....*....|....*....
gi 530396836 194 MALTVIGFLLPFAALLACYCLL-ACRLCR 221
Cdd:cd15210  165 TFLFVFGFVLPCLVIIICYARReDRRLTR 193
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
27-311 3.59e-13

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 68.69  E-value: 3.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAV---YTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVR 103
Cdd:cd15338    1 VIMPSVFGVICFLGIIGNSIVIYTIVKKSKFRCQQTVpdiFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLIT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 104 FLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVaVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPP 183
Cdd:cd15338   81 ALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICL-VWILSLLSITPVWMYAGLMPLPDGSVGCALLLP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 184 ALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGP-AEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAY 262
Cdd:cd15338  160 NPETDTYWFTLYQFFLAFALPLVVICVVYFKILQNMASTVAPlPQRSLRVRTKKVTRMAVAICLAFFICWAPFYILQLAH 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 263 LAVrSTPGVpctvleAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15338  240 LSI-DRPSL------AFLYAYNVAISMGYANSCINPFLYIMLSETFKRQ 281
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
35-309 3.98e-13

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 68.76  E-value: 3.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  35 AVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSI 114
Cdd:cd15131    9 LLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYSTI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 115 LFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPtaIFAATGIQ-RNRTVCYDLSpPALATHYMPYG 193
Cdd:cd15131   89 LNITALSVERYFAICFPLRAKVVVTKRRVK-LVILVLWAVSFLSAGP--IFVLVGVEhENGTNPIDTN-ECKATEYAVRS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 194 MALTV------IGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISF----LPFHITKtaYL 263
Cdd:cd15131  165 GLLTImvwvssVFFFLPVFCLTVLYSLIGRKLWRRRRENIGPNASHRDKNNRQTVKMLAVVVFAFvlcwLPFHVGR--YL 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 264 AVRSTPgvPCTVLEAFAAAYKGTRPFA--SANSVLDPILFYFTQKKFR 309
Cdd:cd15131  243 FSKSFE--AGSLEIALISQYCNLVSFVlfYLSAAINPILYNIMSKKYR 288
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
44-310 5.04e-13

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 67.77  E-value: 5.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRlvrflFYANLH-----GSILFL 117
Cdd:cd15061   17 NLLVILAVATTRRLRTITNCYIVSLATADLLVGVlVLPLAIIRQLLG-YWPLGSHLCD-----FWISLDvllctASILNL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 118 TCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPpalathymPYGMALT 197
Cdd:cd15061   91 CCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCYYTYDK--------GYRIYSS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 198 VIGFLLPFAALLACYCLLACRLCRQDGPAEPVAqerrgkaarmavVVAAAFAISFLPFHITktaYLavrSTPGVPCTVLE 277
Cdd:cd15061  163 MGSFFLPLLLMLFVYLRIFRVIAKERKTAKTLA------------IVVGCFIVCWLPFFIM---YL---IEPFCDCQFSE 224
                        250       260       270
                 ....*....|....*....|....*....|...
gi 530396836 278 AFAAAYKGTRPFasaNSVLDPILFYFTQKKFRR 310
Cdd:cd15061  225 ALSTAFTWLGYF---NSVINPFIYAFYNKDFRR 254
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
28-309 5.86e-13

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 67.95  E-value: 5.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICV--ITQICTSRRALTrtaVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFL 105
Cdd:cd15149    2 VIPVFYSLVFIVGILLNGVNfwIFFYVPSNKSFI---VYLKNIVFADLLMSLTFPFKILSDVELGPWQLNVIVCRYSAVI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 106 FYANLHGSILFLTCISFQRYLGICHPLapwHKRGGRRAAW--LVCVAVWLAVTTQCLPTAIFAATGI-QRNRTVCYDL-S 181
Cdd:cd15149   79 FYLNMYVGIIFFGLIGFDRYYKIVKPL---HTSFVQNVGYskALSVVVWMLMAVLSVPNIILTNQSFhEANYTKCARLkS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 182 PPALATHYMPYGMALTVigFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTA 261
Cdd:cd15149  156 ELGIQWHKASNYICVSI--FWVVFLLLIIFYVAISRKIYKSNQKFRRNSTNMKAKSSRNIFSILFVFFVCFVPYHALRIP 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 262 YLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15149  234 YTLSQTGADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFR 281
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-268 7.61e-13

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 67.90  E-value: 7.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  36 VLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSIL 115
Cdd:cd15132   10 LFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYRLWKSRPWIFGEFLCRLYHYISEGCTYATIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 116 FLTCISFQRYLGICHPLAPWHKRGGRRAAWLVcVAVWLAVTTQCLPTaiFAATGIQRNRTVCYDL-------SPPALATH 188
Cdd:cd15132   90 HITALSIERYLAICFPLRAKVLVTRRRVKCVI-AALWAFALLSAGPF--LFLVGVEQDNNIHPDDfsreckhTPYAVSSG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISF----LPFHITKTAYLA 264
Cdd:cd15132  167 LLGIMIWVTTTYFFLPMLCLSFLYGFIGRKLWKSKNDLRGPNAAARERSHRQTVRILAVVVLAFiicwLPFHIGRILFAN 246

                 ....
gi 530396836 265 VRST 268
Cdd:cd15132  247 TEDY 250
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
32-310 1.27e-12

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 67.26  E-value: 1.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYA-CSLPL-LIYNYAQGdhWPFGDFACRLVRFLFYAN 109
Cdd:cd15207    6 SYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGvFCMPFtLVDNILTG--WPFGDVMCKLSPLVQGVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LHGSILFLTCISFQRYLGICHPLAPwhKRGGRRAAWLVcVAVWLAVTTQCLPTAIF-AATGIQRNR----TVCYDLSPPA 184
Cdd:cd15207   84 VAASVFTLVAIAVDRYRAVVHPTEP--KLTNRQAFVII-VAIWVLALAIMIPQALVlEVKEYQFFRgqtvHICVEFWPSD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 LatHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQ--------ERRGKAARMAVVVAAAFAISFLPFH 256
Cdd:cd15207  161 E--YRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGGGSASreaqaavsKKKVRVIKMLIVVVVLFALSWLPLH 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530396836 257 ItktaylavrstpgvpCTVLEAFAAAYKGTR--------PFAS----ANSVLDPILFYFTQKKFRR 310
Cdd:cd15207  239 T---------------VTMLDDFGNLSPNQRevlyvyiyPIAHwlayFNSCVNPIVYGYFNRNFRK 289
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
23-214 1.44e-12

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 66.57  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  23 NFKQLLLPPVysavLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGDHWPFGDFACRL 101
Cdd:cd15052    1 NWAALLLLLL----VIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLlVMPLSILTELFGGVWPLPLVLCLL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 102 VRFLFYANLHGSILFLTCISFQRYLGICHPLapWHKRG-GRRAAWLVCVAVWLAVTTQCLPTAIFaatGIQRNRTVCYDL 180
Cdd:cd15052   77 WVTLDVLFCTASIMHLCTISLDRYMAIRYPL--RTRRNkSRTTVFLKIAIVWLISIGISSPIPVL---GIIDTTNVLNNG 151
                        170       180       190
                 ....*....|....*....|....*....|....
gi 530396836 181 SPPALATHYMPYGmalTVIGFLLPFAALLACYCL 214
Cdd:cd15052  152 TCVLFNPNFVIYG---SIVAFFIPLLIMVVTYAL 182
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
32-132 1.96e-12

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 66.25  E-value: 1.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADL--LYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYAN 109
Cdd:cd14995    6 LVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLmvLVAAGLPNEIESLLGPDSWIYGYAGCLLITYLQYLG 85
                         90       100
                 ....*....|....*....|...
gi 530396836 110 LHGSILFLTCISFQRYLGICHPL 132
Cdd:cd14995   86 INASSLSITAFTIERYIAICHPM 108
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
28-212 3.47e-12

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 65.68  E-value: 3.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYN-YAQGdhWPFGDFACRLvrFLF 106
Cdd:cd15079    2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNsFYEG--WALGPLGCQI--YAF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHG--SILFLTCISFQRYLGICHPLAPwhKRGGRRAAWLVCVAVWLAVTTQCLPTAIFaatGIQR-----NRTVC-Y 178
Cdd:cd15079   78 LGSLSGigSIWTNAAIAYDRYNVIVKPLNG--NPLTRGKALLLILFIWLYALPWALLPLLF---GWGRyvpegFLTSCsF 152
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 530396836 179 D-LSPPALATHYMpygMALTVIGFLLPFAALLACY 212
Cdd:cd15079  153 DyLTRDWNTRSFV---ATIFVFAYVIPLIIIIYCY 184
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
33-257 3.69e-12

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 65.66  E-value: 3.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHG 112
Cdd:cd16002    7 YSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 113 SILFLTCISFQRYLGICHPLAPwhkRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHY-MP 191
Cdd:cd16002   87 SIYSMTAIALDRYMAIIHPLQP---RLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPEHEERKYeTV 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530396836 192 YGMALTVIGFLLPFAALLACYCLLACRLCRQDGPA-------EPVAQERrgKAARMAVVVAAAFAISFLPFHI 257
Cdd:cd16002  164 YHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGdssdryhEQVSAKR--KVVKMMIVVVCTFAICWLPYHI 234
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
32-216 3.92e-12

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 65.80  E-value: 3.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVIT-QICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANL 110
Cdd:cd15169    6 LYVAAFALGFPLNVLAIRgATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFAPL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRT--------------V 176
Cdd:cd15169   86 YAGGGFLAALSAGRYLGAAFPLG-YQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSntslgintpvngspV 164
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 530396836 177 CYDLSPPALAThymPYGMALTVIGFLLPFAALLACY--CLLA 216
Cdd:cd15169  165 CLEAWDPASAG---PARFSLSLLLFFLPLAITAFCYvgCLRA 203
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
37-311 4.75e-12

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 65.21  E-value: 4.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  37 LAA--GLPLNICVITQICTSRRALTR--TAVYTLNLALADLLYACSLPLLIyNYAQGDHWPFGDFACRLVRFLFYANLHG 112
Cdd:cd15122    9 LAAllGLPGNGFIIWSILWKMKARGRsvTCILILNLAVADGAVLLLTPFFI-TFLTRKTWPFGQAVCKAVYYLCCLSMYA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 113 SILFLTCISFQRYLGICHP-LAPWHKRggRRAAWLVCVAVWLAVTTQCLPTAIF--AATGIQRNRTVC--YDLSPPALAT 187
Cdd:cd15122   88 SIFIIGLMSLDRCLAVTRPyLAQSLRK--KALVRKILLAIWLLALLLALPAFVYrhVWKDEGMNDRICepCHASRGHAIF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 188 HYmpygMALTVIGFLLPFAALLACYCLLACRLCRQDGpaepvaqERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRS 267
Cdd:cd15122  166 HY----TFETLVAFVLPFGVILFSYSVILVRLKGARF-------RRRARVEKLIAAIVVAFALLWVPYHVVNLLQVVANL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 268 TPGvpcTVLEAFAAAYKGTRPFASA----NSVLDPILFYFTQKKFRRR 311
Cdd:cd15122  235 APG---EVLEKLGGAAKAARAGATAlaffSSSVNPLLYVFAAGDLIKT 279
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
44-236 1.94e-11

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 63.58  E-value: 1.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLiYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15393   18 NFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLfSIPFQ-FQAALLQRWVLPRFMCPFCPFVQVLSVNVSVFTLTVIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLAPWHKRggRRAAWLVCVaVWLAVTTQCLPTAIFAATGIQRNRTvcYDLSPPALATHYMP------YGMAL 196
Cdd:cd15393   97 DRYRAVIHPLKARCSK--KSAKIIILI-IWILALLVALPVALALRVEELTDKT--NNGVKPFCLPVGPSddwwkiYNLYL 171
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 530396836 197 TVIGFLLPFAALLACYCLLACRL--CRQDGPAEPVAQERRGK 236
Cdd:cd15393  172 VCVQYFVPLVIICYAYTRIAVKIwgTKAPGNAQDVRDDEILK 213
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
44-213 4.71e-11

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 62.48  E-value: 4.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15212   18 NCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALlCLPFAFLTLFSRPGWLFGDRLCLANGFFNACFGIVSTLTMTLISF 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPlaPWHKRGGRRAAWLVcVAVWLAVTTQCLPTAIFAATGIQRNRTV---CYDLSPPALATHYMPYGMALTVI 199
Cdd:cd15212   98 DRYYAIVRQ--PQGKIGRRRALQLL-AAAWLTALGFSLPWYLLASAPEYYEKLGfyhCLYVLHSGPSRLGAAYSSVLIVL 174
                        170
                 ....*....|....
gi 530396836 200 GFLLPFAalLACYC 213
Cdd:cd15212  175 CYLLPFA--LMCFC 186
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
31-160 4.73e-11

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 62.65  E-value: 4.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  31 PVYSAVL-AAGLPLNICVITQICTSRRALTRTAVYTL--NLALADLLYACSL-PLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd14981    4 PAPPALMfVFGVLGNLLALIVLARSSKSHKWSVFYRLvaGLAITDLLGILLTsPVVLAVYASNFEWDGGQPLCDYFGFMM 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLapWH-KRGGRRAAWLVCVAVWLAVTTQCL 160
Cdd:cd14981   84 SFFGLSSLLIVCAMAVERFLAITHPF--FYnSHVKKRRARLMLGAVWAFALLIAS 136
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
44-309 5.31e-11

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 62.29  E-value: 5.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSL-PLLI---YNYAqgdhWPFGDFACRLVRFLFYANLHGSILFLTC 119
Cdd:cd15074   18 NGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGyPLAIisaFAHR----WLFGDIGCVFYGFCGFLFGCCSINTLTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 120 ISFQRYLGICHP-LAPWHKrggRRAAWLVCVAVWL-AVTTQCLPTAIFAATGIQRNRTVC-YDLSPPALATHYMPYGMAL 196
Cdd:cd15074   94 ISIYRYLKICHPpYGPKLS---RRHVCIVIVAIWLyALFWAVAPLVGWGSYGPEPFGTSCsIDWTGASASVGGMSYIISI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 197 TVIGFLLPFAALLACYCLlacrlcrqdgpaepVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRS-----TPGV 271
Cdd:cd15074  171 FIFCYLLPVLIIVFSYVK--------------IIRKVKSSRKRVAGFDSRSKRQHKIERKVTKVAVLICAGfliawTPYA 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 530396836 272 PCTVLEAFAAAYK-----GTRP--FASANSVLDPILFYFTQKKFR 309
Cdd:cd15074  237 VVSMWSAFGSPDSvpilaSILPalFAKSSCMYNPIIYLLFSSKFR 281
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
33-223 5.42e-11

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 62.53  E-value: 5.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHG 112
Cdd:cd15395    7 YSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCISITV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 113 SILFLTCISFQRYLGICHPLApWhkRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQ------------RNRTVCYDL 180
Cdd:cd15395   87 SIFSLVLIAIERHQLIINPRG-W--RPNNRHAYVGIAVIWVLAVLTSLPFLIFQVLTDEpfknvnvsldayKGKYVCLDQ 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 530396836 181 SPpaLATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQD 223
Cdd:cd15395  164 FP--SDTIRLSYTTCLLVLQYFGPLCFIFICYLKIYIRLKRRN 204
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
32-216 5.95e-11

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 62.14  E-value: 5.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC--SLPLLIYNYAQGDHWPfgDFACRLVRFLFYAN 109
Cdd:cd15387    6 VLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfqVLPQLIWDITFRFYGP--DFLCRLVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LHGSILFLTCISFQRYLGICHPLAPWHKRGGRR---AAWLVCVAVWLAvttqclPTAIFAATGIQRNRTVCY-DLSPPAL 185
Cdd:cd15387   84 MFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVyvlFSWLLSLVFSIP------QVHIFSLREVGNGVYDCWaDFIQPWG 157
                        170       180       190
                 ....*....|....*....|....*....|.
gi 530396836 186 ATHYMPYgmaLTVIGFLLPFAALLACYCLLA 216
Cdd:cd15387  158 PKAYITW---ITLSVYIIPVLILSVCYGLIS 185
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
33-219 1.11e-10

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 61.34  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYA--CSLPLLIYNYAQgdHWPFGDFACRLVRFLFYANL 110
Cdd:cd15205    7 YVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITffCIPFTLLQNISS--NWLGGAFMCKMVPFVQSTAV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVaVWLAVTT--------QCLPTAIFAATGiQRNRTVCYDLSP 182
Cdd:cd15205   85 VTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGL-VWIVSVIvgspmlfvQQLEVKYDFLYE-KRHVCCLERWYS 162
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530396836 183 PalaTHYMPYGMALTVIGFLLPFAALLACYCLLACRL 219
Cdd:cd15205  163 P---TQQKIYTTFILVILFLLPLTTMLFLYSRIGYEL 196
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
32-212 1.20e-10

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 60.82  E-value: 1.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPL-----NICVITQICTSRRALTRTAVYTLNLALADLLYACS-LPLLIYNYAQGDHWPFGDFACRLVRFL 105
Cdd:cd15053    1 NYWALFLLLLPLltvfgNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILvMPFAVYVEVNGGKWYLGPILCDIYIAM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 106 FYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRaAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPpal 185
Cdd:cd15053   81 DVMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKR-VLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEECRFYNP--- 156
                        170       180
                 ....*....|....*....|....*..
gi 530396836 186 athymPYGMALTVIGFLLPFAALLACY 212
Cdd:cd15053  157 -----DFIIYSSISSFYIPCIVMLLLY 178
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
36-305 1.43e-10

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 60.98  E-value: 1.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  36 VLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC--SLPLLIYNYAqGDHWPFGDFACRLVRFLFYANLHGS 113
Cdd:cd15198   10 ILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGgtALSQIIWELL-GDRWMAGDVACRLLKLLQASARGAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 114 ILFLTCISFQRYLGICHPLA-PWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPY 192
Cdd:cd15198   89 ANLVVLLALDRHQAIRAPLGqPLRAWKLAALGWLLALLLALPQAYVFRVDFPDDPASAWPGHTLCRGIFAPLPRWHLQVY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 193 GMALTVIGFLLPFAALLACYCLLACRLCRQdGPAEPVAQERRGKAARMAVVVAAAFAI----------------SF---- 252
Cdd:cd15198  169 ATYEAVVGFVAPVVILGVCYGRLLLKWWER-ANQAPGAKKPWKKPSKSHLRATAPSALprakvktlkmtlvialLFvgcs 247
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530396836 253 LPFHITKTAYlAVRSTPGVPCTVLEAFaaaykgtRPFASANSVLDPILFYFTQ 305
Cdd:cd15198  248 LPYFIAELAA-AFGSGDWEPEKVAAAL-------GVMAVANSATNPFVFLFFN 292
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
31-215 2.02e-10

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 60.48  E-value: 2.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  31 PVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYA-CSLPL-LIYNYAQgdHWPFGDFACRLVRFLFYA 108
Cdd:cd15206    5 PLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAvFCMPFtLVGQLLR--NFIFGEVMCKLIPYFQAV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 109 NLHGSILFLTCISFQRYLGICHPLAP--WHKrggRRAAWLVCVAVWLAVTTQCLPTAIFA--ATGIQRNRTVCYDLSPPA 184
Cdd:cd15206   83 SVSVSTFTLVAISLERYFAICHPLKSrvWQT---LSHAYKVIAGIWLLSFLIMSPILVFSnlIPMSRPGGHKCREVWPNE 159
                        170       180       190
                 ....*....|....*....|....*....|.
gi 530396836 185 LATHYmpYGMALTVIGFLLPFAALLACYCLL 215
Cdd:cd15206  160 IAEQA--WYVFLDLMLLVIPGLVMSVAYGLI 188
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
32-221 2.36e-10

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 60.40  E-value: 2.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSR-RALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANL 110
Cdd:cd15382    6 VYSVLFLIAAVGNLTVLLILLRNRrRKRSRVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRAFGL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPL--APWHKRGGR--RAAWLVCVA-----VWL-------AVT--TQCLPTAIFAATGiqr 172
Cdd:cd15382   86 YLSSFVLVCISLDRYFAILKPLrlSDARRRGRImlAVAWVISFLcsipqSFIfhveshpCVTwfSQCVTFNFFPSHD--- 162
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 173 nrtvcydlsppalatHYMPYGMALTVIGFLLPFAALLACYCLLACRLCR 221
Cdd:cd15382  163 ---------------HELAYNIFNMITMYALPLIIIVFCYSLILCEISR 196
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
44-311 2.96e-10

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 60.04  E-value: 2.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15083   18 NGLVIYAFCRFKSLRTPANYLIINLAISDFLMCIlNCPLMVISSFSG-RWIFGKTGCDMYGFSGGLFGIMSINTLAAIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAI-FAATGIQRNRTVCydlSPPALATHYMP--YGMALTVI 199
Cdd:cd15083   97 DRYLVITRPMKASVRISHRRAL-IVIAVVWLYSLLWVLPPLFgWSRYVLEGLLTSC---SFDYLSRDDANrsYVICLLIF 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 200 GFLLPFAALLACYCL--------------LACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAv 265
Cdd:cd15083  173 GFVLPLLIIIYCYSFifravrrhekamkeMAKRFSKSELSSPKARRQAEVKTAKIALLLVLLFCLAWTPYAVVALIGQF- 251
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 530396836 266 rsTPGVPCTVLEAFAAAYkgtrpFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15083  252 --GYLEVLTPLATAIPAA-----FAKTSAIYNPVIYAFSHPKFRRA 290
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
30-199 3.08e-10

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 60.21  E-value: 3.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  30 PPVYSAVL-AAGLPLNICVITQICTSRRALTRTAVYTL--NLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLVRF- 104
Cdd:cd15142    3 PPTIPAVMfIFGVVGNLIAIVVLCKSRKEQKETTFYTLvcGLAVTDLLGTClASPVTIATYLKG-RWPGGQPLCEYFSFi 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 105 -LFYANLHGSIlfLTCISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWLA-VTTQCLPTAIFAATGIQRNRTVCY---- 178
Cdd:cd15142   82 lLFFSLSGLSI--ICAMSIERYLAINHAYF-YNHYVDKRLAGLTLFAIYASnILFCALPSMGLGKSKLQYPKTWCFidwr 158
                        170       180
                 ....*....|....*....|.
gi 530396836 179 DLSPPALATHYMPYGMALTVI 199
Cdd:cd15142  159 TNVSVHAAYSYMYAGFSSLLI 179
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
27-227 3.25e-10

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 60.23  E-value: 3.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15396    1 FLLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLApWhKRGGRRAAWLVcVAVWLAVTTQCLPTAIF------------AATGIQRNR 174
Cdd:cd15396   81 SVSVSVSIFSLVLIAIERYQLIVNPRG-W-KPSASHAYWGI-VLIWLFSLMISIPFLIFhqltdepfrnlsSHSDFYKDK 157
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530396836 175 TVCYDLSPPalATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAE 227
Cdd:cd15396  158 VVCIEAWPS--ETERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNSKID 208
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
33-222 4.67e-10

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 59.75  E-value: 4.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYnYAQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15397    7 YSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLvCLPFTVV-YTLMDYWIFGEVLCKMTPFIQCMSVT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLApWhkRGGRRAAWLVCVAVWLAVTTQCLPtaiFAATGIQRN---------------RTV 176
Cdd:cd15397   86 VSILSLVLIALERHQLIINPTG-W--KPSVSQAYLAVVVIWMLACFISLP---FLAFHILTDepyknlshffapladKAV 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 530396836 177 CYDLSPpaLATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQ 222
Cdd:cd15397  160 CTESWP--SEHHKLAYTTWLLLFQYCLPLLFILVCYLRIYLRLRRR 203
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
33-229 4.77e-10

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 59.92  E-value: 4.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTrTAVYTLNLALADLLYACSLPLLIYNYAqgDHWPFGDFACRLVRFLFYANLHG 112
Cdd:PHA02834  35 YILLFIFGLIGNVLVIAVLIVKRFMFV-VDVYLFNIAMSDLMLVFSFPFIIHNDL--NEWIFGEFMCKLVLGVYFVGFFS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 113 SILFLTCISFQRYLGICHplAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPY 192
Cdd:PHA02834 112 NMFFVTLISIDRYILVVN--ATKIKNKSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQCIFNDYHENFSWSAFF 189
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 530396836 193 GMALTVIGFLLPFAALLACY--CLLACRLCRQDGPAEPV 229
Cdd:PHA02834 190 NFEINIFGIVIPLIILIYCYskILYTLKNCKNKNKTRSI 228
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
44-217 6.09e-10

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 59.24  E-value: 6.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLY-ACSLPLLIyNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15048   18 NLLVILAFIKDKKLRTVSNFFLLNLAVADFLVgLVSMPFYI-PYTLTGKWPFGKVFCKAWLVVDYTLCTASALTIVLISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIfaATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFL 202
Cdd:cd15048   97 DRYLSVTKAVKYRAKQTKRRTV-LLMALVWILAFLLYGPAII--GWDLWTGYSIVPTGDCEVEFFDHFYFTFITSVLEFF 173
                        170
                 ....*....|....*
gi 530396836 203 LPFAALLACYCLLAC 217
Cdd:cd15048  174 IPFISVSFFNLLIYL 188
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
44-310 8.14e-10

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 58.49  E-value: 8.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLY-ACSLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15049   18 NILVILSFRVNRQLRTVNNYFLLSLACADLIIgLVSMNLYTVYLVMG-YWPLGPLLCDLWLALDYVASNASVMNLLLISF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLAPWHKRGGRRAAWLVCVAvWLaVTTQCLPTAIFAATGIQRNRTV----CYD--LSPPALAThympygmAL 196
Cdd:cd15049   97 DRYFSVTRPLTYRAKRTPKRAILMIALA-WV-ISFVLWAPAILGWQYFVGERTVpdgqCYIqfLDDPAITF-------GT 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 197 TVIGFLLPFAALlacyCLLACRLCRQdgpaepVAQERrgKAARMAVVVAAAFAISFLPFHItktayLAVRSTPGVPCTVL 276
Cdd:cd15049  168 AIAAFYLPVLVM----TILYWRIYRE------TARER--KAARTLSAILLAFIITWTPYNI-----LVLVSTFCAKCIPD 230
                        250       260       270
                 ....*....|....*....|....*....|....
gi 530396836 277 EAFAAAYKgtrpFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15049  231 TLWSFGYW----LCYINSTINPFCYALCNKTFRK 260
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
33-310 8.83e-10

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 58.44  E-value: 8.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15310    7 YCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATlVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRG--GRRAAWLVCVAVW-LAVTTQCLPTAIFAATGiqrNRTVCyDLSPPALATH 188
Cdd:cd15310   87 ASILNLCAISIDRYTAVVMPVHYQHGTGqsSCRRVSLMITAVWvLAFAVSCPLLFGFNTTG---DPTVC-SISNPDFVIY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YmpygmalTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAqerrgkaarmavVVAAAFAISFLPF---HITKTAYLAV 265
Cdd:cd15310  163 S-------SVVSFYLPFGVTLLVYVRIYVVLLREKKATQMLA------------IVLGAFIVCWLPFfltHILNTHCQAC 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 530396836 266 RSTPGVpctvleafaaaYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15310  224 HVPPEL-----------YSATTWLGYVNSALNPVIYTTFNIEFRR 257
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
32-223 1.11e-09

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 58.41  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQIcTSRRALTRTAVYTLNLALADLLY-ACSLPL-LIYNYAQGDHWPFGDFA---CRLVRFLF 106
Cdd:cd14978    6 VLPVICIFGIIGNILNLVVL-TRKSMRSSTNVYLAALAVSDILVlLSALPLfLLPYIADYSSSFLSYFYayfLPYIYPLA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPwHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNR-TVCYDLSPPAL 185
Cdd:cd14978   85 NTFQTASVWLTVALTVERYIAVCHPLKA-RTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCnNNSYYYVIPTL 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 530396836 186 ATHYMPYGM-----ALTVIGFLLPFAALLACYCLLACRLCRQD 223
Cdd:cd14978  164 LRQNETYLLkyyfwLYAIFVVLLPFILLLILNILLIRALRKSK 206
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
29-311 1.28e-09

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 58.37  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  29 LPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYA 108
Cdd:cd15124    3 IPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 109 NLHGSILFLTCISFQRYLGICHPLapwhKRGGRRAAWLVCVA---VWLAVTTQCLPTAIFA------ATGIQRNRTVCYD 179
Cdd:cd15124   83 SVGVSVFTLTALSADRYKAIVRPM----DIQASNALMKICLKaalIWILSMLLAIPEAVFSdlhpfyDKSTNKTFVSCAP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 180 LsPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQ--DGPAEPVAQ-----ERRGKAARMAVVVAAAFAISF 252
Cdd:cd15124  159 Y-PHSNELHPKIHSMASFLIFYVIPLSIISVYYYFIAKNLIRSayNLPVEGNVHvrrqiESRKRLAKTVLVFVGLFAFCW 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530396836 253 LPFHITktaYLaVRS--TPGVPCTVLEAFAAAYkgTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15124  238 LPNHII---YL-YRSyhYSEVDTSMLHFVSSIC--ARILAFTNSCVNPFALYLLSKSFRKQ 292
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
27-311 1.33e-09

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 57.91  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSR-RALTRTAVYTLNLALADLLY-ACSLPLLIYNYAQgDHWPFGDFACRLVRF 104
Cdd:cd15097    1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSGqSGHNTTNLFILNLSVADLCFiLFCVPFQATIYSL-EGWVFGSFLCKAVHF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 105 LFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVaVWLAVTTQCLPTAIFAATGIQRNRTVCYdlsPPA 184
Cdd:cd15097   80 FIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIAL-IWGLSLLFAGPYLSYYDLIDYANSTVCM---PGW 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 185 LATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERR--GKAARMAVVVAAAFAISFLPFHITKTAY 262
Cdd:cd15097  156 EEARRKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTAVDPLEAMSESKRakRKVTKMIIIVTALFCLCWLPHHVVILCY 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 263 LAVRsTPGVPCTVleAFAAAykgTRPFASANSVLDPILFYFTQKKFRRR 311
Cdd:cd15097  236 LYGD-FPFNQATY--AFRLL---SHCMAYANSCLNPIVYALVSKHFRKG 278
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
34-164 1.61e-09

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 57.95  E-value: 1.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  34 SAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLL-YACSLPLLIYNYAQGDH-WPFGDFACRLVRFLFYANLH 111
Cdd:cd15356   11 WALGAAGNALTIHLVLKKRSLRGLQGTVHYHLVSLALSDLLiLLISVPIELYNFVWFHYpWVFGDLVCRGYYFVRDICSY 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCvAVWLAVTTQCLPTAI 164
Cdd:cd15356   91 ATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLA-LIWASSLGFALPMAF 142
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
44-212 1.61e-09

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 58.23  E-value: 1.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQ 123
Cdd:cd15058   18 NLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 124 RYLGICHPLAPWHKRGGRRAAWLVCVaVWL-AVTTQCLPTAIFAATGIQRNRTVCYDlSPPALATHY-MPYGMALTVIGF 201
Cdd:cd15058   98 RYIAITRPLRYQVLLTKRRARVIVCV-VWIvSALVSFVPIMNQWWRANDPEANDCYQ-DPTCCDFRTnMAYAIASSVVSF 175
                        170
                 ....*....|.
gi 530396836 202 LLPFAALLACY 212
Cdd:cd15058  176 YIPLLIMIFVY 186
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
44-212 1.81e-09

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 57.88  E-value: 1.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15056   18 NLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVlVMPFGAIELVNN-RWIYGETFCLVRTSLDVLLTTASIMHLCCIAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPlaPWHKRGGRRAAWLVCVAVWLavttqcLPTAI--------FAATGIQRNRTVCYDLSPPALAthYM---P 191
Cdd:cd15056   97 DRYYAICCQ--PLVYKMTPLRVAVMLGGCWV------IPTFIsflpimqgWNHIGIEDLIAFNCASGSTSCV--FMvnkP 166
                        170       180
                 ....*....|....*....|.
gi 530396836 192 YGMALTVIGFLLPFAALLACY 212
Cdd:cd15056  167 FAIICSTVAFYIPALLMVLAY 187
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
35-310 1.94e-09

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 57.65  E-value: 1.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  35 AVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLL-YACSLPLLIYNYAQGDH-WPFGDFACRLVRFLFYANLHG 112
Cdd:cd15130   12 VVGTVGNSVTLFTLARKKSLQSLQSTVRYHLGSLALSDLLiLLLAMPVELYNFIWVHHpWAFGDAGCRGYYFLRDACTYA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 113 SILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCvAVWLAVTTQCLPTAIF------AATGIQRNRTVCYDLSPPALA 186
Cdd:cd15130   92 TALNVASLSVERYLAICHPFKAKTLMSRSRTKKFIS-AIWLASALLAIPMLFTmglqneSDDGTHPGGLVCTPIVDTATL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYMPYGmalTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQerrgkaarmavVVAAAFAISFLPFHITKTAYLAVr 266
Cdd:cd15130  171 KVVIQVN---TFMSFLFPMLVTSILNTVIANKLVQALRRGVLVLR-----------AVVIAFVVCWLPYHVRRLMFCYI- 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 530396836 267 STPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15130  236 SDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQ 279
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
33-236 2.14e-09

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 57.78  E-value: 2.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYA--CSLPLLIYNYAQGdhWPFGDFACRLVRFLFYANL 110
Cdd:cd15208    7 YILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIiiCLPATLLVDVTET--WFFGQVLCKIIPYLQTVSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLApwHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAATGI---QRNRTVCYDLSPPALAT 187
Cdd:cd15208   85 SVSVLTLSCIALDRWYAICHPLM--FKSTAKRAR-VSILIIWIVSLLIMIPQAIVMECSRvvpLANKTILLTVCDERWSD 161
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530396836 188 HYMP--YGMALTVIGFLLPFAALLACYCLLACRL-CRQDGPAEPVAQERRGK 236
Cdd:cd15208  162 SIYQkvYHICFFLVTYLLPLCLMILAYFQIFRKLwCRQIPGTSSVVQRKWNK 213
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
28-212 4.07e-09

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 56.76  E-value: 4.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYacSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15171    2 LVPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCF--LLTLPFWAHAAWHGGSLGNPTCKVLVALSS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSP---PA 184
Cdd:cd15171   80 VGLHSEALFNVLLTVQASRVFFHGRLASSARRVAPCGIIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFSRPhflPA 159
                        170       180
                 ....*....|....*....|....*....
gi 530396836 185 LATHYMPY-GMALTVIGFLLPFAALLACY 212
Cdd:cd15171  160 EETFWKYFlTLKMNIVVLVFPLLVFIICC 188
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
32-309 4.60e-09

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 56.41  E-value: 4.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGDHWPFGDFACRLVRFLFYANL 110
Cdd:cd15357    6 VYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLfGMPLEVYEMWSNYPFLFGPVGCYFKTALFETVC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLAPwHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQR--NRTVCYDLSPPALATH 188
Cdd:cd15357   86 FASILSVTTVSVERYVAILHPFRA-KLNSTRERALKIIVVLWVLSVLFSIPNTSIHGIKLQYfpNGTLIPDSATCTVVKP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 189 YMPYGMALTVIGFL---LPFAALLACYCLLACRLcRQDGPAEP------VAQERRGKAARMAVVVAAAFAISFLPFHITK 259
Cdd:cd15357  165 LWIYNLIIQITSLLfyvLPMGVISVLYYLMGLKL-RGDKSLEAdemnvnIQRPSRKSVTKMLFVLVLVFAICWAPFHVDR 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530396836 260 T--AYLAVRSTPgvpctVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15357  244 LffSFVVEWTEP-----LANVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFR 290
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
44-309 5.10e-09

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 56.37  E-value: 5.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15391   18 NYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALfCMPFTFTQIMLG-HWVFPAPMCPIVLYVQLVSVTASVLTNTAIGI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLapwHKRGGRRAAWLVCVAVWLAVTTqcLPTAIFAATGIQR------NRTVCYDlSPPALATHYMPYGMAL 196
Cdd:cd15391   97 DRFFAVIFPL---RSRHTKSRTKCIIASIWAISFS--LSSVQLFAGRTQRygqyseGRVLCGE-SWPGPDTSRSAYTVFV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 197 TVIGFLLPFAALLACYCLLACRLCRQDGPAEPVaQER-------RGKAARMAVVVAAAFAISFLPFHITktaYLAVRSTP 269
Cdd:cd15391  171 MLLTYIIPLLILTSTYGYVGFRLWNRTAPGNAD-KGRddmqiksKRKVIKMLVFVVLMFGICWLPLHLF---NLVQDFST 246
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 530396836 270 GVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15391  247 VFRNMPQHTTRLIYGACHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
44-152 5.24e-09

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 56.11  E-value: 5.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQ 123
Cdd:cd15299   21 NILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFD 100
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 530396836 124 RYLGICHPLAPWHKRGGRRA------AWLVCVAVW 152
Cdd:cd15299  101 RYFSITRPLTYRAKRTTKRAgvmiglAWVISFVLW 135
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
40-310 5.63e-09

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 56.18  E-value: 5.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  40 GLPLNICVITQICTSRRALTRTAVYTLNLALADLLYA--CSLPLL-IYNYAQgdHWPFGDFACRLVRFLfyANLHG--SI 114
Cdd:cd15337   14 GVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSavNGFPLKtISSFNK--KWIWGKVACELYGFA--GGIFGfmSI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 115 LFLTCISFQRYLGICHPLaPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAI----FAATGIQRNRTVCY-DLSPPALAthy 189
Cdd:cd15337   90 TTLAAISIDRYLVIAKPL-EAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFgwgrYVPEGFQTSCTFDYlSRDLNNRL--- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 190 mpYGMALTVIGFLLPFAALLACYCLLACRLCRQD---------GPAEPVAQERRGKAARMAVVVAAAFAISFlpFHITKT 260
Cdd:cd15337  166 --FILGLFIFGFLCPLLIIIFCYVNIIRAVRNHEkemtqtaksGMGKDTEKNDARKKAEIRIAKVAIILISL--FLLSWT 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530396836 261 AYLAVrstpgvpcTVLEAFAAAYKGTrP--------FASANSVLDPILFYFTQKKFRR 310
Cdd:cd15337  242 PYAVV--------ALLGQFGPAYWIT-PyvselpvmFAKASAIYNPIIYALSHPKFRA 290
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
31-223 6.27e-09

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 55.90  E-value: 6.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  31 PVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANL 110
Cdd:cd14964    3 IILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGAN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTaifAATGIQRNRTVCYDLSPPALATHYm 190
Cdd:cd14964   83 LASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPL---VGKGAIPRYNTLTGSCYLICTTIY- 158
                        170       180       190
                 ....*....|....*....|....*....|...
gi 530396836 191 pYGMALTVIGFLLPFAALLACYCLLACRLCRQD 223
Cdd:cd14964  159 -LTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRV 190
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
32-221 6.65e-09

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 55.98  E-value: 6.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYA-CSLPLLIYNYAQGDhWPFGDFACRLVRFLFYANL 110
Cdd:cd15979    6 LYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAvFCMPFTLIPNLMGT-FIFGEVICKAVAYLMGVSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLAP--WHKRGgrrAAWLVCVAVWLAVTTQCLPTAIFAATgiqrnRTVCYDLSPPAL-AT 187
Cdd:cd15979   85 SVSTFSLVAIAIERYSAICNPLQSrvWQTRS---HAYRVIAATWLLSGLIMIPYPVYSVT-----VPVPVGDRPRGHqCR 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 530396836 188 HYMPYG-------MALTVIGFLLPFAALLACYCLLACRLCR 221
Cdd:cd15979  157 HAWPSAqvrqawyVLLLLILFFIPGVVMIVAYGLISRELYR 197
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
44-219 6.86e-09

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 55.90  E-value: 6.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADL-----LYACSLPLLIYNyaqgdHWPFGDFACRLVRFLFYANLHGSILFLT 118
Cdd:cd15073   18 NGIVLVTFVKFRELRTPTNALIINLAVTDLgvsiiGYPFSAASDLHG-----SWKFGYAGCQWYAFLNIFFGMASIGLLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 119 CISFQRYLGICHPlaPWHKRGGRRAAWLVCVAVWL-AVTTQCLPTAIFAatgiqrnrtvCYDLSPPALA---------TH 188
Cdd:cd15073   93 VVAVDRYLTICRP--DLGRKMTTNTYTVMILLAWTnAFFWAAMPLVGWA----------SYALDPTGATctinwrkndSS 160
                        170       180       190
                 ....*....|....*....|....*....|.
gi 530396836 189 YMPYGMALTVIGFLLPFAALLACYCLLACRL 219
Cdd:cd15073  161 FVSYTMSVIVVNFIVPLAVMFYCYYNVSRFV 191
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
44-212 7.30e-09

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 56.01  E-value: 7.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQgDHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15400   18 NLLVIISVFRNRKLRNSGNVFVVSLALADLVVALyPYPLVLVAIFH-NGWALGEMHCKVSGFVMGLSVIGSIFNITGIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTaiFAATGIQRNRTVcYDLSPPALATHYmpYGMALTVIGFL 202
Cdd:cd15400   97 NRYCYICHSFA-YDKLYSRWNTLLYVCLIWALTVVAIVPN--FFVGSLEYDPRI-YSCTFVQTASSS--YTIAVVVIHFI 170
                        170
                 ....*....|
gi 530396836 203 LPFAALLACY 212
Cdd:cd15400  171 VPITVVSFCY 180
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
32-211 8.12e-09

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 55.94  E-value: 8.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC--SLPLLIYNYAqgDHWPFGDFACRLVRFLFYAN 109
Cdd:cd15388    6 VLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFfqVLPQLVWDIT--DRFRGPDVLCRLVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LHGSILFLTCISFQRYLGICHPLAPWHKrggRRAAWLVCVAV-WLAVTTQCLPTA-IFAATGIQRNRTVCYdlsppalAT 187
Cdd:cd15388   84 MFASSYMIVAMTFDRHQAICRPMVTFQK---GRARWNGPVCVaWAISLILSLPQVfIFSKVEVAPGVYECW-------AC 153
                        170       180
                 ....*....|....*....|....*....
gi 530396836 188 HYMPYGMA-----LTVIGFLLPFAALLAC 211
Cdd:cd15388  154 FIEPWGLKayvtwITLVVFVLPTLIITVC 182
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
67-309 9.55e-09

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 55.68  E-value: 9.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  67 NLALADLLYA-CSLPLLIYNYAQGDhWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYlgicHPLAPWHKRGG----- 140
Cdd:cd15977   41 SLALGDLLYIlIAIPINVIKLIAED-WPFGVHVCKLYPFIQKASVGITVLSLCALSIDRY----RAVASWSRIRGigipv 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 141 RRAAWLvcVAVWLAVTTQCLPTAI-FAATGIQ-RNRTVCYDLSPPALATHYMPYGMALTV-----IGFLLPFAALLACYC 213
Cdd:cd15977  116 WKAVEV--TLIWAVAIIVAVPEAIaFDMVEIDyRGQTLLVCMLPMEQTSSFMRFYQDVKDwwlfgFYFCLPLACTGVFYT 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 214 LLACR-LCRQDGP--AEPVAQERRGKAARMAVVVAAAFAISFLPFHIT----KTAYLAVRSTPGVPCTVLeaFAAAYKGT 286
Cdd:cd15977  194 LMSCEmLSIKNGMriALNDHMKQRREVAKTVFCLVVIFALCWLPLHLSrilkKTIYDVKDPQRCELLSFL--LVMDYTGI 271
                        250       260
                 ....*....|....*....|...
gi 530396836 287 RpFASANSVLDPILFYFTQKKFR 309
Cdd:cd15977  272 N-MASLNSCINPVALYFVSRKFK 293
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
32-171 1.51e-08

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 55.19  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVI--TQICTSRRALTRT-AVYTLNLALADLL-YACSLPLLIYNYAQGDH-WPFGDFACRLVRFLF 106
Cdd:cd15135    6 LYSLILVAGILGNSATIkvTQVLQKKGYLQKSvTDHMVSLACSDLLvLLLGMPVELYSAIWDPFaTPSGNIACKIYNFLF 85
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGrRAAWLVCvAVWLavTTQCLPTAIFAATGIQ 171
Cdd:cd15135   86 EACSYATILNVATLSFERYIAICHPFKYKALSGS-RVRLLIC-FVWL--TSALVALPLLFAMGTE 146
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
44-212 2.15e-08

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 54.72  E-value: 2.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACS-LPLLIYNYAQgDHWPFGDFACRLvrFLFYANLHG--SILFLTCI 120
Cdd:cd15336   18 NALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTqSPIFFVNSLH-KRWIFGEKGCEL--YAFCGALFGitSMITLLAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 121 SFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPT----AIFAATGIQRNRTVCYDLSPPAlathYMPYGMAL 196
Cdd:cd15336   95 SLDRYLVITKPLASIRWVSKKRAM-IIILLVWLYSLAWSLPPlfgwSAYVPEGLLTSCTWDYMTFTPS----VRAYTMLL 169
                        170
                 ....*....|....*.
gi 530396836 197 TVIGFLLPFAALLACY 212
Cdd:cd15336  170 FCFVFFIPLGIIIYCY 185
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
44-310 2.57e-08

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 54.19  E-value: 2.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15307   18 NILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVlVMPLGILTLVKG-HFPLSSEHCLTWICLDVLFCTASIMHLCTISV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALathympYGMALTVIGFL 202
Cdd:cd15307   97 DRYLSLRYPMR-FGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDHASVLVNGTCQIPDPV------YKLVGSIVCFY 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 203 LPFAALLACYCLLACRLCRQdgpaepvaQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAA- 281
Cdd:cd15307  170 IPLGVMLLTYCLTVRLLARQ--------RSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHw 241
                        250       260
                 ....*....|....*....|....*....
gi 530396836 282 AYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15307  242 VFDVVTWLGYASSMVNPIFYTIFNKVFRQ 270
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
32-236 3.55e-08

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 54.07  E-value: 3.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLL-YACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANL 110
Cdd:cd15133    6 TYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLvLLLGMPLELYELWQNYPFLLGSGGCYFKTFLFETVC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLAP------WHKRGGRRAAWLVCVAVWLAVTTqclPTAIFAATGIQRNRTVCYDLSPPA 184
Cdd:cd15133   86 LASILNVTALSVERYIAVVHPLAArtcstrPRVTRVLGCVWGVSMLCALPNTS---LHGIKFLGSGVPASAQCTVRKPQA 162
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530396836 185 LathympYGMALTVIG---FLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGK 236
Cdd:cd15133  163 I------YNMIPQHTGhlfFVLPMAVISVLYLLMALRLARERGLDATGAGSKIGT 211
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
36-222 5.19e-08

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 53.53  E-value: 5.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  36 VLAAGLplNICVITQICTSR-RALTRTAVYTLNLALADLLYACS-LPL-LIYNYAQGdhWPFGDFACRLVRFLFYANLHG 112
Cdd:cd15383   12 VLSACS--NLAVLWSATRNRrRKLSHVRILILHLAAADLLVTFVvMPLdAAWNVTVQ--WYAGDLACRLLMFLKLFAMYS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 113 SILFLTCISFQRYLGICHPLApwHKRGGRRAAWLVCVAvWLAVTTQCLPTAIfaatgIQRNRTVcydlSPPA----LATH 188
Cdd:cd15383   88 SAFVTVVISLDRHAAILNPLA--IGSARRRNRIMLCAA-WGLSALLALPQLF-----LFHTVTA----TPPVnftqCATH 155
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 530396836 189 --------YMPYGMALTVIGFLLPFAALLACYCLLACRLCRQ 222
Cdd:cd15383  156 gsfpahwqETLYNMFTFFCLFLLPLLIMIFCYTRILLEISRR 197
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
44-198 5.49e-08

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 53.05  E-value: 5.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQ 123
Cdd:cd17790   18 NLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNLLIISFD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 124 RYLGICHPLAPWHKRGGRRAAWLVCVAvWLAVTTQCLPTAIFAATgIQRNRTV----CYD--LSPP------ALATHYMP 191
Cdd:cd17790   98 RYFSITRPLTYRAKRTPRRAAIMIGLA-WLISFVLWAPAILFWQY-LVGERTVlagqCYIqfLSQPiitfgtAIAAFYLP 175

                 ....*..
gi 530396836 192 YGMALTV 198
Cdd:cd17790  176 VTIMIIL 182
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
32-212 6.48e-08

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 53.29  E-value: 6.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC--SLPLLIYNYAQGDHWPfgDFACRLVRFLFYAN 109
Cdd:cd15385    6 VLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFfqVLPQLCWDITYRFYGP--DFLCRIVKHLQVLG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LHGSILFLTCISFQRYLGICHPLAPWHKRGGRraAWLVCVAVWLAVTTQCLPTA-IFAATGIQRNRTVcYDlsppALATH 188
Cdd:cd15385   84 MFASTYMLVMMTADRYIAICHPLKTLQQPTKR--SYLMIGSAWALSFILSTPQYfIFSLSEIENGSGV-YD----CWANF 156
                        170       180
                 ....*....|....*....|....*....
gi 530396836 189 YMPYGMA-----LTVIGFLLPFAALLACY 212
Cdd:cd15385  157 IVPWGIKayitwITISIFVVPVIILLTCY 185
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
44-213 6.77e-08

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 52.72  E-value: 6.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRaLTRTAVYTL-NLALADLLYACS-LPL-LIYNYAQGdhWPFGDFACRLVRFLFYANLHGSILFLTCI 120
Cdd:cd15064   18 NALVIAAILLTRK-LHTPANYLIaSLAVADLLVAVLvMPLsAVYELTGR--WILGQVLCDIWISLDVTCCTASILHLCVI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 121 SFQRYLGICHPLAPWHKRGGRRAAWLVCVaVWLAVTTQCLPTAIFAATGIQRNRTVCydlsppaLATHYMPYGMALTVIG 200
Cdd:cd15064   95 ALDRYWAITDAVEYAHKRTPKRAAVMIAL-VWTLSICISLPPLFGWRTPDSEDPSEC-------LISQDIGYTIFSTFGA 166
                        170
                 ....*....|...
gi 530396836 201 FLLPFAALLACYC 213
Cdd:cd15064  167 FYIPLLLMLILYW 179
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
44-212 1.26e-07

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 52.09  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGDhWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15209   18 NLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIyPYPLILHAIFHNG-WTLGQLHCQASGFIMGLSVIGSIFNITAIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPT----------AIFAATGIQRNRTVcydlsppalathympY 192
Cdd:cd15209   97 NRYCYICHSLQ-YDRLYSLRNTCCYLCLTWLLTVLAVLPNffigslqydpRIYSCTFAQTVSTV---------------Y 160
                        170       180
                 ....*....|....*....|
gi 530396836 193 GMALTVIGFLLPFAALLACY 212
Cdd:cd15209  161 TITVVVIHFLLPLLIVSFCY 180
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
27-132 1.29e-07

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 52.16  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSR--RALTRTAVYTL-NLALADLL-YACSLPLLIYNYAQGDH-WPFGDFACRL 101
Cdd:cd15355    1 VLVTAIYLALFVVGTVGNSITLYTLARKKslQHLQSTVHYHLaSLALSDLLiLLLAMPVELYNFIWVHHpWAFGDAACRG 80
                         90       100       110
                 ....*....|....*....|....*....|.
gi 530396836 102 VRFLFYANLHGSILFLTCISFQRYLGICHPL 132
Cdd:cd15355   81 YYFLRDACTYATALNVASLSVERYLAICHPF 111
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
44-221 1.44e-07

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 52.05  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRalTRTAVYTL--NLALADLL--YACSLPLLIYNYAQgdHWPFGDFACRLVRFLFYANLHGSILFLTC 119
Cdd:cd15384   18 NLLTIIQIYRLRR--SRRTIYSLllHLAIADLLvtFFCIPSEAIWAYTV--AWLAGNTMCKLVKYLQVFGLYLSTYITVL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 120 ISFQRYLGICHPLApwHKRGGRRAAWLVCVAvWLAVTTQCLPTA-IF--AATGIQRNRTVCYDLSPPALATHYMPYGMAL 196
Cdd:cd15384   94 ISLDRCVAILYPMK--RNQAPERVRRMVTVA-WILSPIFSIPQAvIFhvERGPFVEDFHQCVTYGFYTAEWQEQLYNMLS 170
                        170       180
                 ....*....|....*....|....*
gi 530396836 197 TVIGFLLPFAALLACYCLLACRLCR 221
Cdd:cd15384  171 LVFMFPIPLVIMVTCYVLIFITLSK 195
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
36-310 1.53e-07

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 52.04  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  36 VLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADL--LYACSLPLLIYNYAQgdHWPFGDFACRLVRFLFYANLHGS 113
Cdd:cd15000    9 VVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLltLLVCPWMFLVHDFFQ--NYVLGSVGCKLEGFLEGSLLLAS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 114 ILFLTCISFQRYLGIchpLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAAtgiQRNRT-VCYDLSPPALATHYMP- 191
Cdd:cd15000   87 VLALCAVSYDRLTAI---VLPSEARLTKRGAKIVIVITWIVGLLLALPLAIYRS---YRERQwKNFLETYCAENTQVLPi 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 192 YGMALTVIGFLLPFAALLACYCLLACRLCRQDGPA----EPVAQERRGKAARMAVVVAAAFAISFLPFhitkTAYLAVR- 266
Cdd:cd15000  161 YWHVIITVLVWLPLGIMLICYSAIFWKLDKYERRVlrreHPSVVRYKKKAAKTLFIVLITFVVCRIPF----TALIFYRy 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 267 ---STPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15000  237 klvPNDNTQNSVSGSFHILWFASKYLMFLNAAVNPLIYGFTNENFRK 283
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
44-212 1.57e-07

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 51.83  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQ 123
Cdd:cd15401   18 NLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIGSVFNITAIAIN 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 124 RYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTaiFAATGIQRNRTVcydLSPPALATHYMPYGMALTVIGFLL 203
Cdd:cd15401   98 RYCYICHSLR-YDKLYNMKKTCCYVCLTWVLTLAAIVPN--FFVGSLQYDPRI---YSCTFAQTVSSSYTITVVVVHFIV 171

                 ....*....
gi 530396836 204 PFAALLACY 212
Cdd:cd15401  172 PLSIVTFCY 180
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
44-152 1.59e-07

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 51.57  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQ 123
Cdd:cd15300   18 NVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVMNLLVISFD 97
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 530396836 124 RYLGICHPLAPWHKRGGRRA------AWLVCVAVW 152
Cdd:cd15300   98 RYFSITRPLTYRAKRTPKRAgimiglAWLISFILW 132
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
44-153 1.91e-07

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 51.58  E-value: 1.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRL-VRF--LFYAnlhGSILFLTC 119
Cdd:cd15065   17 NVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALlVMTFAVVNDLLG-YWLFGETFCNIwISFdvMCST---ASILNLCA 92
                         90       100       110
                 ....*....|....*....|....*....|....
gi 530396836 120 ISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWL 153
Cdd:cd15065   93 ISLDRYIHIKKPLK-YERWMTTRRALVVIASVWI 125
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
44-154 2.07e-07

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 51.50  E-value: 2.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACS-LPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15329   18 NALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLvMPLAIIYELSG-YWPFGEILCDVWISFDVLLCTASILNLCAISV 96
                         90       100       110
                 ....*....|....*....|....*....|..
gi 530396836 123 QRYLGICHPLAPWHKRGGRRAAWLVcVAVWLA 154
Cdd:cd15329   97 DRYLVITRPLTYAVKRTPKRMALMI-AIVWLL 127
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
29-310 2.41e-07

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 51.34  E-value: 2.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  29 LPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFL--- 105
Cdd:cd14996    3 LPIIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFYWKYQSTQCRIANFFgtl 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 106 -FYANLHGSILFLTCISFQRYL------------GICHPLAPWH----KRGGRRAAWLvCVAVWLAVTTQCLP----TAI 164
Cdd:cd14996   83 vIHVSMCVSILILSWIAISRYAtlmkhdsatqkqSCYEKIFYGHflkrFRQPKFARYL-CIYIWGVVLCIIIPvvvyYSV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 165 FAATGIQRNrtVCYDLSPPALATHYMPYGM-ALTVIGFLlpFAALLACYCLLACRLCR-QDGPAEPVAQERRGKAARMAV 242
Cdd:cd14996  162 READEDGES--LCYNRQVELGAKGSQIAGLiATTFFFLF--FLVVLLSYYSFVNHLRRiQKNTCISEKDLIYRSVKRNIL 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530396836 243 VVAAAFAISFLPFHITKTAYLAVRSTPGvpCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd14996  238 IIQALLVVCFLPYHIFKPVFYVLHQRED--CQQLNYLIETKNILTCLASARSSTDPIMYLLLDKTFKK 303
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
44-176 2.50e-07

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 51.36  E-value: 2.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYnYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15301   18 NVMVMISFKIDKQLQTISNYFLFSLAVADFAIGViSMPLFTV-YTALGYWPLGYEVCDTWLAIDYLASNASVLNLLIISF 96
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLAPWHKRGGRRA------AWLVCVAVWlavttqclPTAIFAATGIQRNRTV 176
Cdd:cd15301   97 DRYFSVTRPLTYRARRTTKKAavmiasAWIISLLLW--------PPWIYSWPYIEGKRTV 148
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
43-132 3.10e-07

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 51.02  E-value: 3.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  43 LNICVITQICTSRRALTRTAVYTLNLALADLLYACSL-PLLIYNYAqGDHWPFGDFACRLVRFLFYANLHGSILFLTCIS 121
Cdd:cd15055   17 GNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVmPFSMIRSI-ETCWYFGDTFCKLHSSLDYILTSASIFNLVLIA 95
                         90
                 ....*....|.
gi 530396836 122 FQRYLGICHPL 132
Cdd:cd15055   96 IDRYVAVCDPL 106
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
44-169 3.31e-07

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 50.96  E-value: 3.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACS-LPLLIYNYAQgDHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15063   18 NLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLvLPFSAVNEVL-DVWIFGHTWCQIWLAVDVWMCTASILNLCAISL 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 123 QRYLGICHPLAPWHKRGGRRAAWLVcVAVWLAVTTQCLPTAIFAATG 169
Cdd:cd15063   97 DRYLAITRPIRYPSLMSTKRAKCLI-AGVWVLSFVICFPPLVGWNDG 142
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
44-310 3.48e-07

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 50.75  E-value: 3.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYaQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQ 123
Cdd:cd14972   16 NSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSV-LLVSLTPSPATWLLRKGSLVLSLLASAYSLLAIAVD 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 124 RYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPtaIFAATGIQRNRTVCYDLSPPaLATHYmpygMALTVIGFLL 203
Cdd:cd14972   95 RYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLP--VLGWNCVLCDQESCSPLGPG-LPKSY----LVLILVFFFI 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 204 PFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAY 283
Cdd:cd14972  168 ALVIIVFLYVRIFWCLWRHANAIAARQEAAVPAQPSTSRKLAKTVVIVLGVFLVCWLPLLILLVLDVLCPSVCDIQAVFY 247
                        250       260
                 ....*....|....*....|....*..
gi 530396836 284 KGTRPfASANSVLDPILFYFTQKKFRR 310
Cdd:cd14972  248 YFLVL-ALLNSAINPIIYAFRLKEMRR 273
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
33-261 4.00e-07

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 50.59  E-value: 4.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLY-ACSLPLLIYnYAQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15399    7 YCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVnTLCLPFTLV-YTLLDEWKFGAVLCHLVPYAQALAVH 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLapwHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQR-----NRTVCYDLSPPALA 186
Cdd:cd15399   86 VSTVTLTVIALDRHRCIVYHL---ESKISKKISFLIIGLTWAASALLASPLAIFREYSVIEispdfKIQACSEKWPNGTL 162
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530396836 187 THYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGP--AEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTA 261
Cdd:cd15399  163 NDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPggGNDHYHQRRRKTTKMLVCVVVVFAVSWLPFHAFQLA 239
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
32-154 5.98e-07

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 50.07  E-value: 5.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYA-CSLPlliYNYAQ--GDHWPFGDFACRLVRFLFYA 108
Cdd:cd15066    5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVAlCAMT---FNASVeiTGRWMFGYFMCDVWNSLDVY 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 530396836 109 NLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVaVWLA 154
Cdd:cd15066   82 FSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLAN-VWIS 126
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
43-161 6.19e-07

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 49.73  E-value: 6.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  43 LNICVITQICTSRRALTRTAVYTLNLALADLLY-ACSLPLLIYnYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCIS 121
Cdd:cd15050   17 LNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVgAVVMPLNIV-YLLESKWILGRPVCLFWLSMDYVASTASIFSLFILC 95
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 530396836 122 FQRYLGICHPLAPWHKRGGRRAAWLVCVAvWLAVTTQCLP 161
Cdd:cd15050   96 IDRYRSVQQPLKYLKYRTKTRASLMISGA-WLLSFLWVIP 134
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
44-204 1.07e-06

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 49.45  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYA-CSLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15008   17 NSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSvASAPFVLLQFTSG-RWTLGSAMCKLVRYFQYLTPGVQIYVLLSICV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLApwhKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATgiqrNRTVCYDLSPPAlATHYMPYGMALTVIGFL 202
Cdd:cd15008   96 DRFYTIVYPLS---FKVSREKAKKMIAASWLFDAAFVSPALFFYGS----NWGPHCNFFLPD-SWDGAAYAIIHLLVGFL 167

                 ..
gi 530396836 203 LP 204
Cdd:cd15008  168 VP 169
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
62-221 1.25e-06

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 49.17  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  62 AVYTLNLALADLLYACSLPLLIYNYAQGDHWPfGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGR 141
Cdd:cd14973   35 SVYILNLAAADFLFLSCQAIQSLEDLLGGSLP-GFALCRLLATLMFFSYTVGLSLLAAISTERCLSVLFPIWYRCHRPKH 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 142 RAAWlVCVAVWLAVTTQCLPTAIFA-ATGIQRNRTVCYDLsppalathympygMALTVIGFLLPFAALLACYCLLACRLC 220
Cdd:cd14973  114 LSAV-VCALLWALSLLLSVLESYFCgFLFWKFNESACRTF-------------NFLSALLFLLLFLVMCVSSLTLLIRVQ 179

                 .
gi 530396836 221 R 221
Cdd:cd14973  180 C 180
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
44-152 1.46e-06

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 48.81  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYA-CSLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15297   18 NILVMVSIKVNRHLQTVNNYFLFSLACADLIIGvFSMNLYTLYTVIG-YWPLGPVVCDLWLALDYVVSNASVMNLLIISF 96
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 530396836 123 QRYLGICHPLAPWHKRGGRR------AAWLVCVAVW 152
Cdd:cd15297   97 DRYFCVTKPLTYPVKRTTKMagmmiaAAWVLSFILW 132
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
44-213 1.57e-06

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 48.74  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACS-LP----LLIYNYaqgdhWPFGDFACRLVRFLFYANLHGSILFLT 118
Cdd:cd15326   18 NILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTvLPfsatLEILGY-----WVFGRIFCDIWAAVDVLCCTASILSLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 119 CISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPAlathympYGMALTV 198
Cdd:cd15326   93 AISIDRYIGVRHSLQ-YPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPAPPDDKVCEITEEPF-------YALFSSL 164
                        170
                 ....*....|....*
gi 530396836 199 IGFLLPFAALLACYC 213
Cdd:cd15326  165 GSFYIPLIVILVMYC 179
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
44-309 1.64e-06

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 48.67  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYaqgdHWPFGDFA--CRLVRFLFYANLHGSILFLTCIS 121
Cdd:cd14989   18 NILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLIEVFNL----NEKYYDIAvlCTFMSLFLQINMYSSIFFLTWMS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 122 FQRYLGICHPLAPWHKRGGRRAAWlVCVAVWLA-VTTQCLPtaiFAATGIQRNRTVCYdlsppALATHYMPYGMALTvIG 200
Cdd:cd14989   94 FDRYIALAKVMKSSPLRTMQHARL-SCGLIWMAsISATLLP---FTAVQAQHTGEVHF-----CFADVREIQWLEVT-LG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 201 FLLPFAALLACYCLLACRLCRQDgpAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVlEAFA 280
Cdd:cd14989  164 FIIPFSIIGLCYSLIVRVLVRAQ--KHRRLRPRRQKALRMILVVVLVFFICWLPENVFISIQLLQGTQEPSESYD-ESFR 240
                        250       260       270
                 ....*....|....*....|....*....|...
gi 530396836 281 AAYKGTRPF----ASANSVLDPILFYFTQKKFR 309
Cdd:cd14989  241 HNHPLTGHIvnlaAFSNSCLNPLIYSFLGETFR 273
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
44-310 1.65e-06

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 48.87  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLY-ACSLPL-LIYNYAQgdHWPFGDFACRLVRFLFYANLHGSILFLTCIS 121
Cdd:cd15051   18 NVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLgLLVLPFsAIYELRG--EWPLGPVFCNIYISLDVMLCTASILNLFAIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 122 FQRYLGICHPLApWHKRGGRRAAWLVCVAVWLA-VTTQCLP------TAIFAATGIQRNRTVCYDLSPpalathymPYGM 194
Cdd:cd15051   96 LDRYLAITAPLR-YPSRVTPRRVAIALAAIWVVsLAVSFLPihlgwnTPDGRVQNGDTPNQCRFELNP--------PYVL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 195 ALTVIGFLLPFAALLACYCLLAC----------RLCRQDGPAEPVAQE--RRGKAARMAVVVAAAFAISFLPFHITKTaY 262
Cdd:cd15051  167 LVAIGTFYLPLLIMCGVYLRIFRiareqakrinALTPASTANSSKSAAtaREHKATVTLAAVLGAFIICWFPYFTYFT-Y 245
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 530396836 263 LAVRSTPgVPCTVLEAfaaaykgTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15051  246 RGLCGDN-INETALSV-------VLWLGYANSALNPILYAFLNRDFRR 285
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
33-310 2.21e-06

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 48.38  E-value: 2.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  33 YSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACS-LPLLIYNYAqGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15123    7 YAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYI-ADTWLFGRIGCKLLSFIQLTSVG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLapwhKRGGRRAAWLVCV---AVWLAVTTQCLPTAIFAA--TGIQRNRTVCYDLSPPALA 186
Cdd:cd15123   86 VSVFTLTVLSADRYRAIVKPL----ELQTSDAVLKTCCkagCVWIVSMLFAIPEAVFSDlySFRDPEKNTTFEACAPYPV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 187 THYM---PYGMALTVIGFLLPFAALLACYCLLACRLCRQ--DGPAEPVAQ-----ERRGKAARMAVVVAAAFAISFLPFH 256
Cdd:cd15123  162 SEKIlqeIHSLLCFLVFYIIPLSIISVYYFLIARTLYKStfNMPAEEHSHarkqiESRKRVAKTVLVLVALFAFCWLPNH 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530396836 257 ITKTaYLAVRSTPGVPCTVLEAFAAAYkgTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15123  242 ILYL-YRSFTYHTSVDSSAFHLIATIF--SRVLAFSNSCVNPFALYWLSKSFRQ 292
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
44-212 2.24e-06

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 48.36  E-value: 2.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQ 123
Cdd:cd15959   18 NLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASIETLCAIAVD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 124 RYLGICHPLApWHKRGGRRAAWLVCVAVW-LAVTTQCLP-TAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGF 201
Cdd:cd15959   98 RYLAITNPLR-YEALVTKRRARTAVCLVWaISAAISFLPiMNQWWRDGADEEAQRCYDNPRCCDFVTNMPYAIVSSTVSF 176
                        170
                 ....*....|.
gi 530396836 202 LLPFAALLACY 212
Cdd:cd15959  177 YVPLLVMIFVY 187
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
32-222 2.75e-06

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 48.23  E-value: 2.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLL-YACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANL 110
Cdd:cd15358    6 TYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLvLLLGMPLELYEMWSNYPFLLGAGGCYFKTLLFETVC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 111 HGSILFLTCISFQRYLGICHPLAPWHKRgGRRAAWLVCVAVWLAVTTQCLPT----AIFAATGIQRNR----TVCYDLSP 182
Cdd:cd15358   86 FASILNVTALSVERYIAVVHPLKAKYVV-TRTHAKRVIGAVWVVSILCSIPNtslhGIFQLTVPCRGPvpdsATCMLVKP 164
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 530396836 183 PALathYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQ 222
Cdd:cd15358  165 RWM---YNLIIQITTLLFFFLPMGTISVLYLLIGLQLKRE 201
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
44-234 3.43e-06

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 47.59  E-value: 3.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYA-----CSLPLLIYNYAqgdhWPFGDFACRLVRFLFYANLHGSILFLT 118
Cdd:cd15305   18 NILVIMAVSLEKKLQNATNFFLMSLAVADMLVGilvmpVSLIAILYDYA----WPLPRYLCPIWISLDVLFSTASIMHLC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 119 CISFQRYLGICHPLApwHKR-GGRRAAWLVCVAVWLAVTTQCLPTAIFaatGIQRNRTVCYDLSPPALATHYMPYGmalT 197
Cdd:cd15305   94 AISLDRYVAIRNPIE--HSRfNSRTKAMMKIAAVWTISIGISMPIPVI---GLQDDEKVFVNGTCVLNDENFVLIG---S 165
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530396836 198 VIGFLLPFAALLACYCLLACRLCRQdgpaEPVAQERR 234
Cdd:cd15305  166 FVAFFIPLIIMVITYCLTIQVLQRQ----QAINNERR 198
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
67-309 4.60e-06

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 47.54  E-value: 4.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  67 NLALADLLY-ACSLPLLIYNYAQGDhWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGIchplAPW-HKRGGRRAA 144
Cdd:cd15976   41 SLALGDLLHiIIDIPINVYKLLAED-WPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAV----ASWsRIKGIGVPK 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 145 WLVC--VAVWLAVTTQCLPTAIF--AATGIQRNRTVCYDLSPPALATHYMPY-----GMALTVIGFLLPFAALLACYCLL 215
Cdd:cd15976  116 WTAVeiVLIWVVSIILAVPEAIGfdMITMDYKGELLRICLLHPIQKTAFMQFyktakDWWLFSFYFCLPLACTAVFYTLM 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 216 ACRLCRQDGPAEPVAQE---RRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVP-CTVLEAFAAA-YKGTRpFA 290
Cdd:cd15976  196 TCEMLRKKNGMQIALNDhlkQRREVAKTVFCLVLVFALCWLPLHLSRILKLTIYDEKDPNrCELLSFFLVLdYIGIN-MA 274
                        250
                 ....*....|....*....
gi 530396836 291 SANSVLDPILFYFTQKKFR 309
Cdd:cd15976  275 SLNSCINPIALYLVSKRFK 293
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
27-154 4.60e-06

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 47.25  E-value: 4.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACS-LPLLIYN-YAQGDHWPFGdfACRLVRF 104
Cdd:cd15232    1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTvVPKLLQNlLTERKTISFG--GCMAQLY 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530396836 105 LFYANLHGSILFLTCISFQRYLGICHPLapwhkRGGRRAAWLVCVA----VWLA 154
Cdd:cd15232   79 FFTWSLGSELLLLTAMAYDRYVAICHPL-----HYSTIMRKEVCVGlatgVWAI 127
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
62-156 4.98e-06

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 47.19  E-value: 4.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  62 AVYTLNLALADLLYAcsLPLLI-------Y--NYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPL 132
Cdd:cd15137   36 SFLIKNLAIADFLMG--VYLLIiasvdlyYrgVYIKHDEEWRSSWLCTFAGFLATLSSEVSVLILTLITLDRFICIVFPF 113
                         90       100
                 ....*....|....*....|....
gi 530396836 133 APwhKRGGRRAAWLVCVAVWLAVT 156
Cdd:cd15137  114 SG--RRLGLRRAIIVLACIWLIGL 135
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
44-212 6.56e-06

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 47.04  E-value: 6.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTR-TAVYTLNLALADLLYAcslpLLIYNYAQ----GDHWPFGDFaCRLVRFLFYANLHGSILFLT 118
Cdd:cd15057   18 NALVIAAVLRFRHLRSKvTNYFIVSLAVSDLLVA----ILVMPWAAvnevAGYWPFGSF-CDVWVSFDIMCSTASILNLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 119 CISFQRYLGICHPLApWHKRGGRRAAWLVCVAVW-LAVTTQCLPtaifaatgIQRNRTVCYDLSPPALATHYMP------ 191
Cdd:cd15057   93 VISVDRYWAISSPFR-YERRMTRRRAFIMIAVAWtLSALISFIP--------VQLGWHRADDTSEALALYADPCqcdssl 163
                        170       180
                 ....*....|....*....|....
gi 530396836 192 ---YGMALTVIGFLLPFAALLACY 212
Cdd:cd15057  164 nrtYAISSSLISFYIPVAIMIVTY 187
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
28-165 7.60e-06

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 46.69  E-value: 7.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFY 107
Cdd:cd15398    2 FLIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQC 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530396836 108 ANLHGSILFLTCISFQRYLGICHPLApwhKRGGRRAAWLVCVAVWLAVTTQCLPTAIF 165
Cdd:cd15398   82 VSVMVSTLMLMSIAIVRYHMIKHPLS---NHLTANHGYFLLGTVWTLGFTICSPLPVF 136
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
44-133 1.02e-05

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 46.47  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLvrflfyanlHG---------S 113
Cdd:cd15314   18 NLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGlVMPPSMVRSVET-CWYFGDLFCKI---------HSsfditlctaS 87
                         90       100
                 ....*....|....*....|
gi 530396836 114 ILFLTCISFQRYLGICHPLA 133
Cdd:cd15314   88 ILNLCFISIDRYYAVCQPLL 107
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
44-226 1.11e-05

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 46.05  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLL----------IYNYAQGdhWPFGDfACRLVRFL--FYANLh 111
Cdd:cd15136   18 NIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLaivdaktlgeYYNYAID--WQTGA-GCKTAGFLavFSSEL- 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 gSILFLTCISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWL-AVTTQCLPtaIFaatGIQRNRTVCYDL---SPPALAT 187
Cdd:cd15136   94 -SVFTLTVITLERWYAITHAMH-LNKRLSLRQAAIIMLGGWIfALIMALLP--LV---GVSSYSKTSICLpfeTETPVSK 166
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 530396836 188 HYMPYGMALTVIGFLLpfaaLLACYCLLACRLCRQDGPA 226
Cdd:cd15136  167 AYVIFLLLFNGLAFLI----ICGCYIKIYLSVRGSGRAA 201
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
27-213 1.14e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 46.04  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15325    1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPAla 186
Cdd:cd15325   81 VLCCTASIMSLCIISIDRYIGVSYPLR-YPSIMTERRGLLALLCVWVLSLVISIGPLFGWKEPAPEDETICQITEEPG-- 157
                        170       180
                 ....*....|....*....|....*..
gi 530396836 187 thympYGMALTVIGFLLPFAALLACYC 213
Cdd:cd15325  158 -----YALFSALGSFYLPLAIILVMYC 179
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
44-165 1.16e-05

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 46.27  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15302   18 NILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLeSMPFYTVYVLNGDYWPLGWVLCDLWLSVDYTVCLVSIYTVLLITI 97
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530396836 123 QRYLGICHPLAPWHKRGGRRAAWLVcVAVWLavttqcLPTAIF 165
Cdd:cd15302   98 DRYCSVKIPAKYRNWRTPRKVLLII-AITWI------IPALLF 133
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
32-126 1.46e-05

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 45.94  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICT-SRRALTRTAVytLNLALADLLYACSLPLLIYNYAQGdHWPFGDFACRLVRFLFYANL 110
Cdd:cd14994    7 LYSVVLIGGVIGVILMSFLLVKmNTRSVTTTAV--INLIVVHSLFLLTVPFRIYYYASK-TWKFGMPLCKMVSAMIHIHM 83
                         90
                 ....*....|....*.
gi 530396836 111 HGSILFLTCISFQRYL 126
Cdd:cd14994   84 HLTFLFYVIILVIRYL 99
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
44-310 1.47e-05

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 45.70  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15323   18 NVLVVIAVLTSRALRAPQNLFLVSLASADILVATlVMPFSLANELMG-YWYFGQVWCNIYLALDVLFCTSSIVHLCAISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLAPWHKRGGRRAAWLVcVAVWLAVTTQCLPTAifaatgIQRNRTVCYDLSPPALATHYMPYGMALTVIGFL 202
Cdd:cd15323   97 DRYWSVTQAVEYNLKRTPRRVKAII-VTVWLISAVISFPPL------ISMYRDPEGDVYPQCKLNDETWYILSSCIGSFF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 203 LPFAALLACYcllaCRLCRqdgpaepVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAa 282
Cdd:cd15323  170 APCLIMILVY----IRIYR-------VAKAREKRFTFVLAVVMGVFVVCWFPFFFSYSLYGICREACEVPEPLFKFFFW- 237
                        250       260
                 ....*....|....*....|....*...
gi 530396836 283 ykgtrpFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15323  238 ------IGYCNSSLNPVIYTIFNQDFRR 259
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
44-310 1.54e-05

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 45.67  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQ 123
Cdd:cd15402   18 NLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFNITGIAIN 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 124 RYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTaIFAATGIQRNRTVCYDLSPPALAThympYGMALTVIGFLL 203
Cdd:cd15402   98 RYCYICHSLK-YDKLYSDKNSLCYVLLIWVLTVAAIVPN-LFVGSLQYDPRIYSCTFAQSVSSA----YTIAVVFFHFIL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 204 PFAALLACYC---LLACRLCRQdgpaepVAQERRGKAARMAVVVAAAFAISFLPFHITKTAY----LAVRSTPG--VPCT 274
Cdd:cd15402  172 PIIIVTFCYLriwILVIQVRRR------VKPDNKPKLKPHDFRNFVTMFVVFVLFAVCWAPLnfigLAVAVDPEtiVPRI 245
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 530396836 275 VLEAFAAAYKgtrpFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15402  246 PEWLFVASYY----MAYFNSCLNAIIYGLLNQNFRR 277
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
67-309 1.60e-05

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 46.01  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  67 NLALADLLY-ACSLPLLIYNYAQGDhWPFGD-----FACRLVRFLFYANLHGSILFLTCISFQRYLGIchplAPWHKRGG 140
Cdd:cd15975   41 SLALGDLIYiVIDIPINVYKLLAQK-WPFDDssfgvFLCKLVPFLQKASVGITVLNLCALSVDRYRAV----ASWSRVQG 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 141 RRAAWLVCV---AVWLAVTTQCLPTAI-FAATGIQRN----RTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACY 212
Cdd:cd15975  116 IGIPLITAIeifSIWVLSFILAIPEAIgFVMVPFEYNgeqyRTCMLNATTKFMNFYVDAKDWWLFGFYFCVPLACTAIFY 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 213 CLLACR-LCRQDGPAEPVAQE---RRGKAARMAVVVAAAFAISFLPFHIT----KTAYLAVRSTpgvPCTVLEAFAAAYK 284
Cdd:cd15975  196 TLMTCEmLNRRKGSLRIALSEhlkQRREVAKTVFCLVVIFALCWFPLHLSrilkKTVYNENDPR---RCELLSFLLVMDY 272
                        250       260
                 ....*....|....*....|....*
gi 530396836 285 GTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15975  273 ISINLATMNSCINPIALYFVSKKFK 297
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
25-157 1.60e-05

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 46.10  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  25 KQLLLPPVYSAVLAAGLPLNICVITQictsrRALTRTAVY-TLNLALADLL-YACSLPLLIYNYAQGDHWPFGDFACRLV 102
Cdd:cd15217    3 KLVLLGLIICVSLAGNLIVSLLVLKD-----RALHKAPYYfLLDLCLADTIrSAVCFPFVLVSIRNGSAWTYSVLSCKIV 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530396836 103 RFLFYANLHGSILFLTCISFQRYLGICHplapwHKRGGRRAAWLVCVAVWLAVTT 157
Cdd:cd15217   78 AFMAVLFCFHAAFMLFCISVTRYMAIAH-----HRFYSKRMTFWTCIAVICMVWT 127
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
56-155 2.30e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 45.53  E-value: 2.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  56 RALTRTAVY-TLNLALADLLYACS-LPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLA 133
Cdd:cd15005   29 RSLHRAPYYfLLDLCLADGLRSLAcFPFVMASVRHGSGWIYGALSCKVIAFLAVLFCFHSAFTLFCIAVTRYMAIAHHRF 108
                         90       100
                 ....*....|....*....|..
gi 530396836 134 PWHKRGGRRAAWLVCVAVWLAV 155
Cdd:cd15005  109 YAKRMTFWTCLAVICMAWTLSV 130
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
35-213 2.56e-05

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 44.83  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  35 AVLAAGLPLNICVIT-------QICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15308    2 AALVGGVLLILAIIAgnvlvclSVCTERALKTTTNYFIVSLAVADLLLALlVLPLYVYSEFQGGVWTLSPVLCDALMTMD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTaIFAATGIQ-RNRTVCydlspPAL 185
Cdd:cd15308   82 VMLCTASIFNLCAISVDRFIAVSVPLN-YNRRQGSVRQLLLISATWILSFAVASPV-IFGLNNVPnRDPAVC-----KLE 154
                        170       180
                 ....*....|....*....|....*...
gi 530396836 186 ATHYMPYGmalTVIGFLLPFAALLACYC 213
Cdd:cd15308  155 DNNYVVYS---SVCSFFIPCPVMLVLYC 179
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
60-255 3.35e-05

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 44.75  E-value: 3.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  60 RTAVYTLNLALADLLYACSL-PL-LIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLApWHK 137
Cdd:cd15220   31 RKFAFVCHLCVVDLLAALLLmPLgILSSSPFFLGVVFGEAECRVYIFLSVCLVSASILTISAISVERYYYIVHPMR-YEV 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 138 RGGRRAAWLVCVAVWLAVTTQCL------PTAIFAATGIQRNRTVCYDLSPpalatHYMPYGMALTVIGFLLPFAALLAC 211
Cdd:cd15220  110 KMTIGLVAAVLVGVWVKALLLGLlpvlgwPSYGGPAPIAARHCSLHWSHSG-----HRGVFVVLFALVCFLLPLLLILVV 184
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 530396836 212 YCLLACRLCRqdgpaepvaqerrGKAARMAVVVAAAFAISFLPF 255
Cdd:cd15220  185 YCGVFKVFGG-------------GKAALTLAAIVGQFLCCWLPY 215
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
32-221 6.39e-05

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 44.09  E-value: 6.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYA--CSLPLLIYNYAQgdHWPFGDFACRLVRFLFYAN 109
Cdd:cd15978    6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLClfCMPFTLIPNLLK--DFIFGSAVCKTATYFMGIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LHGSILFLTCISFQRYLGICHPLAP--WHKRGgrrAAWLVCVAVWLAVTTQCLPTAIFAA----TGIQrNRT--VCYDLS 181
Cdd:cd15978   84 VSVSTFNLVAISLERYSAICKPLKSrvWQTKS---HALKVIAATWCLSFTIMLPYPIYSNlvpfTRIN-NSTgnMCRLLW 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 530396836 182 PPALATHymPYGMALTVIGFLLPFAALLACYCLLACRLCR 221
Cdd:cd15978  160 PNDVTQQ--SWYIFLLLILFLIPGIVMMTAYGLISLELYR 197
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-166 6.96e-05

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 43.79  E-value: 6.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  28 LLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACS-LPLLIYNYAQgDHWPFGDFACRLVRFLF 106
Cdd:cd15125    2 VIPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASRYFY-EEWMFGTVGCKLIPVIQ 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLaPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFA 166
Cdd:cd15125   81 LTSVGVSVFTLTALSADRYKAIVNPM-DIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFS 139
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
32-161 7.89e-05

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 43.57  E-value: 7.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLVRFLFYANL 110
Cdd:cd15060    6 LLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIfVLPLNVAYFLLG-KWLFGIHLCQMWLTCDILCC 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530396836 111 HGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLP 161
Cdd:cd15060   85 TASILNLCAIALDRYWAIHDPINYAQKRTLKRVL-LMIVVVWALSALISVP 134
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-309 8.75e-05

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 43.66  E-value: 8.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  36 VLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLY-ACSLPLLIYNYAQGDhWPFGD-----FACRLVRFLFYAN 109
Cdd:cd15128   10 IFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYiVIDLPINVYKLLAMD-WPFGDqpfgqFLCKLVPFIQKAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 110 LHGSILFLTCISFQRYLGIchplAPWHK-RGGRRAAWLVC--VAVWLAVTTQCLPTAI------FAATGIQrnRTVCYDL 180
Cdd:cd15128   89 VGITVLNLCALSVDRYRAV----ASWSRiQGIGIPMWTAVeiVMIWMLSAVLAVPEAIgfdmvrFNYKGVT--LRTCLLR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 181 SPPALATHYMPY-GMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVA----QERRGKAARMAVVVAAAFAISFLPF 255
Cdd:cd15128  163 PETSFMKFYIDVkDWWLFGFYFCLPLVCTAIFYTLMTCEMLRKRNGMLRIAlnehLKQRREVAKTVFCLVVIFALCWLPL 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530396836 256 HITKTAYLAV--RSTPGvPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFR 309
Cdd:cd15128  243 HLSRILKLTVydQNDPN-RCELLSFLLVLDYFGINLATLNSCINPIALYFVSRKFK 297
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
44-230 8.99e-05

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 43.36  E-value: 8.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQ 123
Cdd:cd15327   18 NILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLCVISVD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 124 RYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPAlathympYGMALTVIGFLL 203
Cdd:cd15327   98 RYVGVKHSLK-YPTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPPPPDESICSITEEPG-------YALFSSLFSFYL 169
                        170       180       190
                 ....*....|....*....|....*....|
gi 530396836 204 PFAALLACYC---LLACRLCRQDGPAEPVA 230
Cdd:cd15327  170 PLMVILVMYFrvyVVALKFSREKKAAKTLA 199
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
44-165 9.09e-05

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 43.47  E-value: 9.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQ 123
Cdd:cd15298   18 NILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFD 97
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 530396836 124 RYLGICHPLApWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIF 165
Cdd:cd15298   98 RYFCVTKPLT-YPARRTTKMAGLMIAAAWVLSFVLWAPAILF 138
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
45-164 1.04e-04

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 43.34  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  45 ICVItqICTSRRALTRTAVYTLNLALADLLYA--CSLPLLIYNYAQGdhWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15980   21 VCFI--VLRSKHMRTVTNLFILNLAISDLLVGifCMPTTLLDNIIAG--WPFGSTVCKMSGMVQGISVSASVFTLVAIAV 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530396836 123 QRYLGICHPLAPwhkRGGRRAAWLVCVAVW-LAVTTQClPTAI 164
Cdd:cd15980   97 DRFRCIVYPFKQ---KLTISTAVVIIVIIWvLAIAIMC-PSAV 135
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
55-310 1.14e-04

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 43.13  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  55 RRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACrLVRFLFYANLHG-SILFLTCISFQRYLGICHPLA 133
Cdd:cd15104   29 RKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLC-LLRMCFVITSCAaSVLSLAAIAFDRYLALKQPLR 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 134 PWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIfaaTGIQRNrtvcyDLSPPA--LATHYMPYGMALTVIGFLLPFAALLAC 211
Cdd:cd15104  108 YKQIMTGKSAGALIAGLWLYSGLIGFLPLIS---PQFQQT-----SYKGKCsfFAAFHPRVLLVLSCMVFFPALLLFVFC 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 212 YC---LLACRLCRQ--------DGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHItkTAYLAVRSTPGVPCTVLEAFA 280
Cdd:cd15104  180 YCdilKIARVHSRAiykvehalARQIHPRRTLSDFKAARTVAVLIGCFLLSWLPFQI--TGLVQALCDECKLYDVLEDYL 257
                        250       260       270
                 ....*....|....*....|....*....|
gi 530396836 281 AAykgtrpFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15104  258 WL------LGLCNSLLNPWIYAFWQKEVRR 281
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
35-153 1.19e-04

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 43.04  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  35 AVLAAGLPLNICVITQICTsRRALTRTAVYTL-NLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGS 113
Cdd:cd15330    9 TLILCAIFGNACVVAAIAL-ERSLQNVANYLIgSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSS 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 530396836 114 ILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAvWL 153
Cdd:cd15330   88 ILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLT-WL 126
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
36-161 1.27e-04

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 42.89  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  36 VLAAGLPLNicVITQICTSRRALTRTAV-YTL-NLALADLLYAC-SLPLLIYNYAQgDHWPFGDFACRLVRFLfyANLHG 112
Cdd:cd15077   10 LVIAGFPIN--VLTIICTIKYKKLRSHLnYILvNLAVANLIVVCfGSTTAFYSFSQ-MYFVLGPLACKIEGFT--ATLGG 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530396836 113 --SILFLTCISFQRYLGICHPLAPWHKRGGRraAWLVCVAVWLAVTTQCLP 161
Cdd:cd15077   85 mvSLWSLAVVAFERFLVICKPLGNFTFRGTH--AIIGCIATWVFGLAASLP 133
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
44-212 1.30e-04

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 42.93  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQ 123
Cdd:cd15957   18 NVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 124 RYLGICHPLApWHKRGGRRAAWLVCVAVWL-AVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFL 202
Cdd:cd15957   98 RYFAITSPFK-YQSLLTKNKARVIILMVWIvSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFY 176
                        170
                 ....*....|
gi 530396836 203 LPFAALLACY 212
Cdd:cd15957  177 VPLVIMVFVY 186
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
44-132 1.64e-04

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 42.54  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALAD-LLYACSLPLLIYNYAQgDHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15318   18 NLFVVVTVSHFKALHTPTNFLLLSLALADmLLGLTVLPFSTIRSVE-SCWYFGDSFCRLHTCLDTLFCLTSIFHLCFISI 96
                         90
                 ....*....|
gi 530396836 123 QRYLGICHPL 132
Cdd:cd15318   97 DRHCAICDPL 106
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
32-222 2.60e-04

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 41.75  E-value: 2.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  32 VYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLH 111
Cdd:cd15215    5 LIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 112 GSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCydlspPALATHYMP 191
Cdd:cd15215   85 AGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAFDERNALC-----SVIWGSSYS 159
                        170       180       190
                 ....*....|....*....|....*....|.
gi 530396836 192 YGMALTVIGFLLPFAALLACYCLLACRLCRQ 222
Cdd:cd15215  160 YTILSVVSSFVLPVIIMLACYSMVFRAARRC 190
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
27-213 2.84e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 41.71  E-value: 2.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  27 LLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLF 106
Cdd:cd15062    1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 107 YANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPAla 186
Cdd:cd15062   81 VLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRAT-VALLIVWVLSLVISIGPLLGWKEPAPADEQACGVNEEPG-- 157
                        170       180
                 ....*....|....*....|....*..
gi 530396836 187 thympYGMALTVIGFLLPFAALLACYC 213
Cdd:cd15062  158 -----YVLFSSLGSFYLPLAIILVMYC 179
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
44-310 3.01e-04

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 41.57  E-value: 3.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLY-ACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15067   17 NLLVILAVLRERYLRTVTNYFIVSLAVADLLVgSIVMPFSILHEMTGGYWLFGRDWCDVWHSFDVLASTASILNLCVISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLApWHKRGGRRAAWLVCVAVWLAvttqclpTAIFAATGIQRNRTVCYDLSPP--ALATHYMPYGMALTVIG 200
Cdd:cd15067   97 DRYWAITDPIS-YPSRMTKRRALIMIALVWIC-------SALISFPAIAWWRAVDPGPSPPnqCLFTDDSGYLIFSSCVS 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 201 FLLPFAALLACYCllacRLCRQdgpaepVAQERrgKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTpgvpCtvLEAFA 280
Cdd:cd15067  169 FYIPLVVMLFTYY----RIYRA------AAKEQ--KAAKTLGIVMGVFILCWLPFFVTNILIGFCPSN----C--VSNPD 230
                        250       260       270
                 ....*....|....*....|....*....|
gi 530396836 281 AAYKGTRPFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15067  231 ILFPLVTWLGYINSGMNPIIYACSSRDFRR 260
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
54-178 3.43e-04

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 41.66  E-value: 3.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  54 SRRALTRTAVYTLNLALADLLYA-CSLPLLIYNYAQ-GDHWpfgDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHP 131
Cdd:cd15108   27 CRGRRTPFCVYVLHLAVADLLFLlCMASTLSLETSPlVITH---DLAYEVVRRVKYFAYTASLSLLTAISTQRCLSVLFP 103
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 530396836 132 LapWHK--RGGRRAAWlVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCY 178
Cdd:cd15108  104 I--WYKchQPRHLSAV-VCALLWALSLLMNVLASFFCSEFWHPDEWQCF 149
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
40-212 4.36e-04

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 41.19  E-value: 4.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  40 GLPLNICVITQICTSRRALTRTAVYTLNLALADLlyACSLPLLIYNYAQG-DHWPFGDFACRLVRFLFYANLHGSILFLT 118
Cdd:cd15072   14 GFSLNGLTILSFCKTRELRTPSNLLVLSLAVADM--GISLNALVAASSSLlRRWPYGSEGCQAHGFQGFFTALASICSSA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 119 CISFQRYLGICHPlapwHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVC-YDLSPPALatHYMPYGMALT 197
Cdd:cd15072   92 AIAWDRYHHYCTR----SKLQWSTAISLVLFVWLFSAFWAAMPLLGWGEYDYEPLGTCCtLDYSKGDR--NYVSYLFTMA 165
                        170
                 ....*....|....*
gi 530396836 198 VIGFLLPFAALLACY 212
Cdd:cd15072  166 FFNFILPLFILLTSY 180
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
47-163 4.51e-04

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 41.56  E-value: 4.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  47 VITQICTSRRALTRTAVY-TLNLALADLL-YACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQR 124
Cdd:cd15218   20 LISILLVKDKTLHRAPYYfLLDLCCSDILrSAICFPFVFTSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTR 99
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 530396836 125 YLGICHplapwHKRGGRRAAWLVCVAVWLAVTTQCLPTA 163
Cdd:cd15218  100 YLAIAH-----HRFYTKRLTFWTCLAVICMVWTLSVAMA 133
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
44-165 5.83e-04

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 41.06  E-value: 5.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15321   24 NVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATlIIPFSLANELMG-YWYFRKTWCEIYLALDVLFCTSSIVHLCAISL 102
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530396836 123 QRYLGICHPLAPWHKRGGRRAAWLVCVaVWLAVTTQCLPTAIF 165
Cdd:cd15321  103 DRYWSVSRAIEYNSKRTPRRIKCIILI-VWLIAAVISLPPLIY 144
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
44-311 6.66e-04

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 40.69  E-value: 6.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRalTRTAVYTL---NLALADLLYACSLpLLI--------YNYAQGDHWPFGDFACRLVRFLFYANLHG 112
Cdd:cd14980   18 NILVIIWHISSKK--KKKKVPKLliiNLAIADFLMGIYL-LIIaiadqyyrGRYAQYSEEWLRSPPCLLACFLVSLSSLM 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 113 SILFLTCISFQRYLGICHPLAPwhKRGGRRAAWLVCVAVWLAvttqclpTAIFAA----TGI-QRNRTVCYDLSPPALAT 187
Cdd:cd14980   95 SVLMMLLITLDRYICIVYPFSN--KRLSYKSAKIILILGWLF-------SIIFAAipilYSInQPGDNRLYGYSSICMPS 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 188 H-----YMPYGMALTVIGFLLpFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAY 262
Cdd:cd14980  166 NvsnpyYRGWLIAYLLLTFIA-WIIICILYILIFISVRKSRKSARRSSSKRDKRIAIRLALILITDLICWLPYYIVIFSG 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530396836 263 LAvrSTPGVPCTVLeafaaaykgtrPFASA-----NSVLDPILFYFTQKKFRRR 311
Cdd:cd14980  245 LL--TSTEIDIHVL-----------QFIAIlalplNSAINPYLYTLTTPTFKRD 285
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
44-161 6.66e-04

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 40.79  E-value: 6.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYACS-LPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15059   18 NVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLiMPFSLVNELMG-YWYFGSVWCEIWLALDVLFCTASIVNLCAISL 96
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 530396836 123 QRYLGICHPLAPWHKRGGRRAAWLVcVAVWLAVTTQCLP 161
Cdd:cd15059   97 DRYWSVTQAVEYNLKRTPRRAKAMI-AAVWIISAVISLP 134
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
44-310 7.07e-04

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 40.70  E-value: 7.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15322   18 NVLVIIAVFTSRALKAPQNLFLVSLASADILVATlVIPFSLANEVMG-YWYFGKVWCEIYLALDVLFCTSSIVHLCAISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCyDLSPPALathympYGMALTVIGFL 202
Cdd:cd15322   97 DRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGPIC-KINDEKW------YIISSCIGSFF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 203 LPFAALLACYCLLAcrlcrqdgpaePVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTpgVPCTVLEAFAAa 282
Cdd:cd15322  170 APCLIMVLVYIRIY-----------QIAKNREKRFTFVLAVVIGVFVICWFPFFFTYTLTAVCDCS--VPETLFKFFFW- 235
                        250       260
                 ....*....|....*....|....*...
gi 530396836 283 ykgtrpFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15322  236 ------FGYCNSSLNPVIYTIFNHDFRR 257
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
43-257 8.10e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 40.29  E-value: 8.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  43 LNICVITQICTSRRaLTRTAVYTL-NLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCIS 121
Cdd:cd15335   17 LNSAVIAAICTTKK-LHQPANYLIcSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 122 FQRYLGICHPLAPWHKRGGRRAAWLVcVAVWLAVTTQCLPTAIFaatgiqRNRtvcYDLSPPALAT---HYMPYGMALTV 198
Cdd:cd15335   96 LDRYWAITDAIEYARKRTAKRAGLMI-LTVWTISIFISIPPLFW------RNH---HDANIPSQCIiqhDHVIYTIYSTF 165
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530396836 199 IGFLLPFAALLACYCLLACrlcrqdgpaepvAQERRGKAARMAVVVAAAFAISFLPFHI 257
Cdd:cd15335  166 GAFYIPLTLILILYYRIYH------------AASRERKAARILGLILGAFILSWLPFFI 212
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
44-218 8.48e-04

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 40.56  E-value: 8.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLY-ACSLPLLIYNYAQGdHWPF-GDFACRLVRFLFYAnLHGSILFLTCIS 121
Cdd:cd15054   18 NSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVgLVVMPPAMLNALYG-RWVLaRDFCPIWYAFDVMC-CSASILNLCVIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 122 FQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAI---FAATGIQRNRTVCYDLSPPALATHYMPYGMALTV 198
Cdd:cd15054   96 LDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELgwhELGHERTLPNLTSGTVEGQCRLLVSLPYALVASC 175
                        170       180
                 ....*....|....*....|..
gi 530396836 199 IGFLLPFAALLACYC--LLACR 218
Cdd:cd15054  176 LTFFLPSGAICFTYCriLLAAR 197
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
44-212 8.64e-04

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 40.31  E-value: 8.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGDhWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15214   17 NLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVlVLPFVVTSSIRRE-WIFGVVWCNFSALLYLLISSASMLTLGAIAI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLAPWHKRGGRRAAwLVCVAVWLAVTTQCLPTAI-FAATGIQRNRTVCydlsppALATHYMP-YGMALTVIG 200
Cdd:cd15214   96 DRYYAVLYPMVYPMKITGNRAV-LALVYIWLHSLIGCLPPLFgWSSLEFDRFKWMC------VAAWHKEAgYTAFWQVWC 168
                        170
                 ....*....|..
gi 530396836 201 FLLPFAALLACY 212
Cdd:cd15214  169 ALLPFVVMLVCY 180
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
44-164 1.24e-03

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 40.19  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYA--CSLPLLIYNYAQGdhWPFGDFACRLVRFLFYANLHGSILFLTCIS 121
Cdd:cd15981   18 NGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGifCMPTTLVDNLITG--WPFDNAMCKMSGLVQGMSVSASVFTLVAIA 95
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 530396836 122 FQRYLGICHPLAPwhkRGGRRAAWLVCVAVW-LAVTTQClPTAI 164
Cdd:cd15981   96 VERFRCIVHPFRQ---KLTLRKAIVTIVIIWvLALIIMC-PSAV 135
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
35-310 1.49e-03

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 39.72  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  35 AVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACS-LPLLIYNYAQGdHWPFGDFACRLvrFLFYANLHG- 112
Cdd:cd15086    9 FILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLgTPFSFAASTQG-RWLIGEHGCRW--YGFANSLFGi 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 113 -SILFLTCISFQRYlgiCHPLAPWHKRGGR-RAAWLVCVAVWLAVTTQCLPTAI-FAATGIQRNRTVCyDLSPPALATHY 189
Cdd:cd15086   86 vSLISLAVLSYERY---CTLLRPTEADVSDyRKAWLGVGGSWLYSLLWTLPPLLgWSSYGPEGPGTTC-SVQWTSRSANS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 190 MPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHItkTAYLAVRSTP 269
Cdd:cd15086  162 ISYIICLFIFCLLLPFLVMVYCYGRLLYAIKQVGKINKSTARKREQHVLLMVVTMVICYLLCWLPYGV--MALLATFGKP 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 530396836 270 GVPCTVLEAFAAAykgtrpFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15086  240 GLVTPVASIVPSI------LAKSSTVVNPIIYVFMNKQFYR 274
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
43-212 1.62e-03

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 39.55  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  43 LNICVITQICTSRRaLTRTAVYTL-NLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCIS 121
Cdd:cd15334   17 INSLVITAIIVTRK-LHHPANYLIcSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 122 FQRYLGICHPLAPWHKRGGRRAAWLVCVaVWLAVTTQCLPTAIFAATGIQRNRTvCYDLSPPALATHYMPYGmaltviGF 201
Cdd:cd15334   96 LDRYRAITDAVEYARKRTPKHAGIMIAV-VWIISIFISMPPLFWRHQTTSREDE-CIIKHDHIVFTIYSTFG------AF 167
                        170
                 ....*....|.
gi 530396836 202 LLPFAALLACY 212
Cdd:cd15334  168 YIPLALILILY 178
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
60-215 1.63e-03

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 39.66  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  60 RTAVYTL--NLALAD-LLYACSLPLLIYNYAQGDhWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLapwH 136
Cdd:cd15213   32 RSAINLLlaNLAFSDiMLSLVCMPFAAVTIITGR-WIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLIIVQRQ---D 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 137 KRGGRRAAWLVCVAvWLAVTTQCLPTAI----FAATGIQRNRTVCYDLSPPALAthympYGMALTVIGFLLPFAALLACY 212
Cdd:cd15213  108 KLNPHRAKILIAVS-WVLSFCVSFPPLVgwgkYEFPPRAPQCVLGYTESPADRI-----YVVLLLVAVFFIPFLIMLYSY 181

                 ....
gi 530396836 213 -CLL 215
Cdd:cd15213  182 fCIL 185
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
44-310 1.83e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 39.35  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALAD-LLYACSLPLLIYNYAQgDHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15317   18 NLVVIISISHFKQLHSPTNMLVLSLATADfLLGLCVMPFSMIRTVE-TCWYFGDLFCKFHTGLDLLLCTTSIFHLCFIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLAPWHKRGgRRAAWLVCVAVWLAVTTQclpTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFL 202
Cdd:cd15317   97 DRYYAVCDPLRYPSKIT-VQVAWRFIAIGWLVPGIY---TFGLIYTGANDEGLEEYSSEISCVGGCQLLFNKIWVLLDFL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 203 LPFAA---LLACYC---LLACRLCRQDGPAEPV-----------AQERRGKAARMAVVVAAAFAISFLPFHITKT--AYL 263
Cdd:cd15317  173 TFFIPcliMIGLYAkifLVARRQARKIQNMEDKfrsseensskaSASRERKAAKTLAIVMGIFLFCWLPYFIDTIvdEYS 252
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530396836 264 AVRStpgvPCTVLEAFAAaykgtrpFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15317  253 NFIT----PAIVFDAVIW-------LGYFNSAFNPFIYAFFYPWFRK 288
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
44-303 2.00e-03

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 39.55  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTR-TAVYTLNLALADLLYAcslpLLIYNYAQ----GDHWPFGDFACRLVRFLFYANLhGSILFLT 118
Cdd:cd15319   18 NILVCAAVVRFRHLRSKvTNIFIVSLAVSDLFVA----LLVMPWKAvaevAGYWPFGAFCDVWVAFDIMCST-ASILNLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 119 CISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHY------MPY 192
Cdd:cd15319   93 VISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQLNWHKDSGDDWVGLHNSSISRQVEENcdsslnRTY 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 193 GMALTVIGFLLPFAALLACYCLL----------------------ACR---LCRQDGPAEPVAQERRGKAARMAVVVAAA 247
Cdd:cd15319  173 AISSSLISFYIPVAIMIVTYTRIyriaqiqirrissleraaehaqSCRsnrIDCHHHTSLRTSIKKETKVLKTLSVIMGV 252
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530396836 248 FAISFLPFHITKTAYLAVRSTP-----GVPC---TVLEAFAAaykgtrpFASANSVLDPILFYF 303
Cdd:cd15319  253 FVCCWLPFFILNCMVPFCDRPPadpdaGLPCvseTTFDVFVW-------FGWANSSLNPIIYAF 309
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
44-310 2.19e-03

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 39.08  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15324   18 NVLVVVAVFTSRALRAPQNLFLVSLASADILVATlVIPFSLANEVMG-YWYFGSTWCAFYLALDVLFCTSSIVHLCAISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 123 QRYLGICHPLAPWHKRGGRRAAWLVCVaVWLAVTTQCLPTAIFAatgiQRNRTVCydlsppaLATHYMPYGMALTVIGFL 202
Cdd:cd15324   97 DRYWSVTKAVSYNLKRTPKRIKRMIAV-VWVISAVISFPPLLMT----KHDEWEC-------LLNDETWYILSSCTVSFF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 203 LPFAALLACYCllacRLCRqdgpaepVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAa 282
Cdd:cd15324  165 APGLIMILVYC----KIYR-------VAKMREKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVCRKRCGIPDALFNLFFW- 232
                        250       260
                 ....*....|....*....|....*...
gi 530396836 283 ykgtrpFASANSVLDPILFYFTQKKFRR 310
Cdd:cd15324  233 ------IGYCNSSVNPIIYTIFNRDFRK 254
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
66-309 2.67e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 39.08  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  66 LNLALADLLYA-CSLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWhkRGGRRAA 144
Cdd:cd15084   50 VNLAVADLLVTlFGSSVSFSNNIVG-FFVFGKTMCEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMGDF--RFQQRHA 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 145 WLVCVAVWLAVTTQCLPTAIFAATGIQRN-RTVCydlSPPAL--ATHYMPYGMALTVIGFLLPFAALLACYC--LLACRL 219
Cdd:cd15084  127 VSGCAFTWGWSLLWTSPPLFGWSSYVPEGlRTSC---GPNWYtgGTNNNSYILALFVTCFALPLSTIIFSYSnlLLTLRA 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 220 CRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFhitKTAYLAVRSTPGVPCTVLEAFAAAYkgtrpFASANSVLDPI 299
Cdd:cd15084  204 VAAQQKESETTQRAEKEVTRMVIAMVMAFLICWLPY---ATFAMVVATNKDVVIQPTLASLPSY-----FSKTATVYNPI 275
                        250
                 ....*....|
gi 530396836 300 LFYFTQKKFR 309
Cdd:cd15084  276 IYVFMNKQFR 285
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
44-154 2.68e-03

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 39.00  E-value: 2.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  44 NICVITQICTSRRALTRTAVYTLNLALADLLY-ACSLPLLIyNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISF 122
Cdd:cd15296   18 NALVILAFVVDSSLRTQGNFFFLNLAISDFLVgGFCIPLYI-PYVLTGRWKFGRGLCKLWLVVDYLLCTASVFNIVLISY 96
                         90       100       110
                 ....*....|....*....|....*....|..
gi 530396836 123 QRYLGICHPLAPWHKRGGRRAAWLVCVAVWLA 154
Cdd:cd15296   97 DRFLSVTRAVSYRAQKGMTRQAVLKMVLVWVL 128
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
36-166 2.97e-03

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 39.02  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  36 VLAAGLPLNICV-ITQICTSR-RALTRTAVYTLNLALADLLYACSLPLLIYnyaQGDHWPFGDFA-CRLVRFLFYANLHG 112
Cdd:PHA03235  42 IISVGGPLNLIVlVTQLLANRvHGFSTPTLYMTNLYLANLLTVFVLPFIML---SNQGLLSGSVAgCKFASLLYYASCTV 118
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530396836 113 SILFLTCISFQRYLGIchplapwHKR-----GGRRAAWLVCVAVWLAVTTQCLPTAIFA 166
Cdd:PHA03235 119 GFATVALIAADRYRVI-------HQRtrarsSAYRSTYKILGLTWFASLICSGPAPVYT 170
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
26-212 6.10e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 37.85  E-value: 6.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  26 QLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFL 105
Cdd:cd15333    4 KISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 106 FYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVaVWLAVTTQCLPTAIFAATGIQRNRTVCydlsppAL 185
Cdd:cd15333   84 DITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIAL-VWVISISISLPPFFWRQAKAEEEVSEC------VV 156
                        170       180
                 ....*....|....*....|....*..
gi 530396836 186 ATHYMPYGMALTVIGFLLPFAALLACY 212
Cdd:cd15333  157 NTDHILYTVYSTVGAFYIPTLLLIALY 183
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
61-212 8.14e-03

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 37.68  E-value: 8.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836  61 TAVYTLNLALADLLYAC-SLPLLIYNYAQGdHWPFGDFACRLVRFLFYANLhGSILFLTCISFQRYLGICHPLAPWHKRG 139
Cdd:cd15320   37 TNFFVISLAVSDLLVAVlVMPWKAVAEIAG-FWPFGSFCNIWVAFDIMCST-ASILNLCVISVDRYWAISSPFRYERKMT 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396836 140 GRRAAWLVCVAVWLAVTTQCLP----------TAIFAATGIQRNRTVcyDLSPPALAThymPYGMALTVIGFLLPFAALL 209
Cdd:cd15320  115 PKVAFIMISVAWTLSVLISFIPvqlnwhkakpTSFLDLNASLRDLTM--DNCDSSLNR---TYAISSSLISFYIPVAIMI 189

                 ...
gi 530396836 210 ACY 212
Cdd:cd15320  190 VTY 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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