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Conserved domains on  [gi|530388080|ref|XP_005273709|]
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stathmin-4 isoform X1 [Homo sapiens]

Protein Classification

stathmin family protein( domain architecture ID 10467180)

stathmin family protein is a small regulatory phosphoprotein, similar to human stathmin that is involved in the regulation of the microtubule filament system by destabilizing microtubules

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Stathmin pfam00836
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ...
 76-201 5.60e-57

Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.


:

Pssm-ID: 459956 [Multi-domain]  Cd Length: 136  Bit Score: 178.31  E-value: 5.60e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388080   76 DMEVIELNKCTSGQSFEVILKPPSFDGVPEFNASLPRRRDPSLEEIQKKLEAAEERRKYQEAELLKHLAEKREHEREVIQ 155
Cdd:pfam00836   2 DTEVKELEKRASGQAFEVILKPPSVNAAPPKLSLSPKKKDSSLEEIQKKLEAAEERRKSLEAQKLKQLAEKREKEEEALQ 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 530388080  156 KAIEENNNFIKMAKEKLAQKMESNKENREAHLAAMLERLQEKVRGP 201
Cdd:pfam00836  82 KADEENNNFSKMAEEKLKQKMEAYKENREAQIAALKEKLKEKEKHV 127
 
Name Accession Description Interval E-value
Stathmin pfam00836
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ...
 76-201 5.60e-57

Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.


Pssm-ID: 459956 [Multi-domain]  Cd Length: 136  Bit Score: 178.31  E-value: 5.60e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388080   76 DMEVIELNKCTSGQSFEVILKPPSFDGVPEFNASLPRRRDPSLEEIQKKLEAAEERRKYQEAELLKHLAEKREHEREVIQ 155
Cdd:pfam00836   2 DTEVKELEKRASGQAFEVILKPPSVNAAPPKLSLSPKKKDSSLEEIQKKLEAAEERRKSLEAQKLKQLAEKREKEEEALQ 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 530388080  156 KAIEENNNFIKMAKEKLAQKMESNKENREAHLAAMLERLQEKVRGP 201
Cdd:pfam00836  82 KADEENNNFSKMAEEKLKQKMEAYKENREAQIAALKEKLKEKEKHV 127
 
Name Accession Description Interval E-value
Stathmin pfam00836
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ...
 76-201 5.60e-57

Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.


Pssm-ID: 459956 [Multi-domain]  Cd Length: 136  Bit Score: 178.31  E-value: 5.60e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388080   76 DMEVIELNKCTSGQSFEVILKPPSFDGVPEFNASLPRRRDPSLEEIQKKLEAAEERRKYQEAELLKHLAEKREHEREVIQ 155
Cdd:pfam00836   2 DTEVKELEKRASGQAFEVILKPPSVNAAPPKLSLSPKKKDSSLEEIQKKLEAAEERRKSLEAQKLKQLAEKREKEEEALQ 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 530388080  156 KAIEENNNFIKMAKEKLAQKMESNKENREAHLAAMLERLQEKVRGP 201
Cdd:pfam00836  82 KADEENNNFSKMAEEKLKQKMEAYKENREAQIAALKEKLKEKEKHV 127
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 105-216 6.90e-03

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 37.43  E-value: 6.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388080  105 EFNASLPRRRDPSLEEIQKKLEAAEE--RRKYQE---AELLKHLAEKREHEREVI-QKAIEENNNFIKMAKEKLAQkmes 178
Cdd:pfam09731 331 ELSARLEEVRAADEAQLRLEFEREREeiRESYEEklrTELERQAEAHEEHLKDVLvEQEIELQREFLQDIKEKVEE---- 406

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 530388080  179 NKENREAHLAAMLERLQEkvrgpwLERSFLGHAVFLLQ 216
Cdd:pfam09731 407 ERAGRLLKLNELLANLKG------LEKATSSHSEVEDE 438
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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