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Conserved domains on  [gi|530379692|ref|XP_005271942|]
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protein Shroom1 isoform X1 [Homo sapiens]

Protein Classification

shroom family protein( domain architecture ID 10282073)

shroom family protein is a PDZ (PSD-95, Dlg, and ZO-1/2) domain-containing protein that functions in cell morphology by coordinating the assembly of both microtubule and actin cytoskeletons

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ASD2 pfam08687
Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which ...
 544-824 3.72e-91

Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.


:

Pssm-ID: 462561 [Multi-domain]  Cd Length: 290  Bit Score: 289.16  E-value: 3.72e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  544 ELVQELARLDPSLCDPLASQPSPEPPLGLLDGLIPlAEVRAAMRPACGEAG----------EEAASTFEPGSYQFSFTQL 613
Cdd:pfam08687   1 ELVKELVPKDKSLADILDPKPSRKTTMDLMEGLFP-EDTLRAMKPDLGEAYkkapseegseEEASGTSSLSSCSAYYTTS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  614 LPAPREETRLENPATHPVLDQPCGQGLPAPNNSIQGKKVELAARLQKMLQDLHTEQERLQGEAQAWARRQAALEAAVRQA 693
Cdd:pfam08687  80 APKAELLTKMKDLTTLPSPDQPEEQGEEELDNDLQQKKVELIESLQRKLQVLREEQEALQEEIQANAALGAEVEALVQEV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  694 CAPQELERFSRFMADLERVLGLLLLLGSRLARVRRALARAASDSDPDEQASLLQRLRLLQRQEEDAKELKEHVARRERAV 773
Cdd:pfam08687 160 CKPNELEKYRMFIGDLEKVVSLLLSLSGRLARVENALSSLDSDADAEERQSLLEKRRLLLRQLEDAKELKENLDRRERVV 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 530379692  774 REVLVRALPVEELRVYCALLAGKAAVLAQQRNLDERIRLLQDQLDAIRDDL 824
Cdd:pfam08687 240 SGILARYLTAEQLQDYRHFVKMKAALLIEQRELDEKIKLGEEQLKALKESL 290
ASD1 super family cl07346
Apx/Shroom domain ASD1; This region is found in the actin binding protein Shroom which ...
 140-256 3.25e-13

Apx/Shroom domain ASD1; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure. ASD1 has been implicated directly in F-actin binding.


The actual alignment was detected with superfamily member pfam08688:

Pssm-ID: 462562 [Multi-domain]  Cd Length: 179  Bit Score: 68.52  E-value: 3.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  140 AYRQRLQGAQRRVLRETSFQRKELRMSLPAR--------------LRPTVPARPPATHPRSASLSHPGGEGEPARSRAPA 205
Cdd:pfam08688  40 AYREKLKDAQSRVLRATSFRRRDLQPSVPPVpwhlssrprpasahLRSPEAPISASPSPHTPRERHSVTPGDRLAGPPAV 119

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 530379692  206 PGTAGRGPLANQQRKWCFSEPGKLDRVGRGGGPareclgEACSSSGLPGPE 256
Cdd:pfam08688 120 RRIGGRKRLTAEQKKRSYSEPEKMNEVGVSPEP------EPAPAPHFMFPE 164
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 70-569 1.08e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692   70 PGPAPPDAALCTSPRPRPAVAARSgPQPTEVPGtPGPLNRQATPLLYALAAEAEAAAQAAEPPSPPASRAAyrQRLQGAQ 149
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDPPPPSPS-PAANEPDP-HPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS--SPPQRPR 2684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  150 RRVLRE-----TSFQRKELRMSLPA-RLRPTVPARPPATHPRSASLSHPGGEGEPARSRAPAPGTAGRGPLANQQRKWCF 223
Cdd:PHA03247 2685 RRAARPtvgslTSLADPPPPPPTPEpAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTA 2764

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  224 SEPGKLDRVGRGGGPARECLGEACSSSGLPGPEPLEFQHPAlakfeDHEVGWLPETQPQGSMNLDSGSLKLGDAFRPASR 303
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA-----DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  304 SR----SASGEVLGSWGGSGGTI----PIVQAVPQGAETPRPLFQtKLSRFLPQkeaavmyPAELPQSSPADSEQRVSET 375
Cdd:PHA03247 2840 PPppgpPPPSLPLGGSVAPGGDVrrrpPSRSPAAKPAAPARPPVR-RLARPAVS-------RSTESFALPPDQPERPPQP 2911

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  376 CIVPAWLPSLPDEVFLEEAPlvRMRSPPDPHASQGPPASVHASDQPYGTGLGQRTGQVtVPTEYPLHECPGTAGADdcwq 455
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPPQPQP--PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL-VPGRVAVPRFRVPQPAP---- 2984

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  456 gvngsvgiSRPTSHTPTGTandniptidPTGLTTNPPTAAESDLLKPVPADALGLSGNDTPGPSHNTALARGTGQPGSRP 535
Cdd:PHA03247 2985 --------SREAPASSTPP---------LTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSDS 3047

                         490       500       510
                  ....*....|....*....|....*....|....
gi 530379692  536 TWPSqcleelVQELARLDPSLCDPLASQPSPEPP 569
Cdd:PHA03247 3048 ERSD------LEALDPLPPEPHDPFAHEPDPATP 3075
 
Name Accession Description Interval E-value
ASD2 pfam08687
Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which ...
 544-824 3.72e-91

Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.


Pssm-ID: 462561 [Multi-domain]  Cd Length: 290  Bit Score: 289.16  E-value: 3.72e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  544 ELVQELARLDPSLCDPLASQPSPEPPLGLLDGLIPlAEVRAAMRPACGEAG----------EEAASTFEPGSYQFSFTQL 613
Cdd:pfam08687   1 ELVKELVPKDKSLADILDPKPSRKTTMDLMEGLFP-EDTLRAMKPDLGEAYkkapseegseEEASGTSSLSSCSAYYTTS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  614 LPAPREETRLENPATHPVLDQPCGQGLPAPNNSIQGKKVELAARLQKMLQDLHTEQERLQGEAQAWARRQAALEAAVRQA 693
Cdd:pfam08687  80 APKAELLTKMKDLTTLPSPDQPEEQGEEELDNDLQQKKVELIESLQRKLQVLREEQEALQEEIQANAALGAEVEALVQEV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  694 CAPQELERFSRFMADLERVLGLLLLLGSRLARVRRALARAASDSDPDEQASLLQRLRLLQRQEEDAKELKEHVARRERAV 773
Cdd:pfam08687 160 CKPNELEKYRMFIGDLEKVVSLLLSLSGRLARVENALSSLDSDADAEERQSLLEKRRLLLRQLEDAKELKENLDRRERVV 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 530379692  774 REVLVRALPVEELRVYCALLAGKAAVLAQQRNLDERIRLLQDQLDAIRDDL 824
Cdd:pfam08687 240 SGILARYLTAEQLQDYRHFVKMKAALLIEQRELDEKIKLGEEQLKALKESL 290
ASD1 pfam08688
Apx/Shroom domain ASD1; This region is found in the actin binding protein Shroom which ...
 140-256 3.25e-13

Apx/Shroom domain ASD1; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure. ASD1 has been implicated directly in F-actin binding.


Pssm-ID: 462562 [Multi-domain]  Cd Length: 179  Bit Score: 68.52  E-value: 3.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  140 AYRQRLQGAQRRVLRETSFQRKELRMSLPAR--------------LRPTVPARPPATHPRSASLSHPGGEGEPARSRAPA 205
Cdd:pfam08688  40 AYREKLKDAQSRVLRATSFRRRDLQPSVPPVpwhlssrprpasahLRSPEAPISASPSPHTPRERHSVTPGDRLAGPPAV 119

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 530379692  206 PGTAGRGPLANQQRKWCFSEPGKLDRVGRGGGPareclgEACSSSGLPGPE 256
Cdd:pfam08688 120 RRIGGRKRLTAEQKKRSYSEPEKMNEVGVSPEP------EPAPAPHFMFPE 164
PHA03247 PHA03247
large tegument protein UL36; Provisional
 70-569 1.08e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692   70 PGPAPPDAALCTSPRPRPAVAARSgPQPTEVPGtPGPLNRQATPLLYALAAEAEAAAQAAEPPSPPASRAAyrQRLQGAQ 149
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDPPPPSPS-PAANEPDP-HPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS--SPPQRPR 2684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  150 RRVLRE-----TSFQRKELRMSLPA-RLRPTVPARPPATHPRSASLSHPGGEGEPARSRAPAPGTAGRGPLANQQRKWCF 223
Cdd:PHA03247 2685 RRAARPtvgslTSLADPPPPPPTPEpAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTA 2764

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  224 SEPGKLDRVGRGGGPARECLGEACSSSGLPGPEPLEFQHPAlakfeDHEVGWLPETQPQGSMNLDSGSLKLGDAFRPASR 303
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA-----DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  304 SR----SASGEVLGSWGGSGGTI----PIVQAVPQGAETPRPLFQtKLSRFLPQkeaavmyPAELPQSSPADSEQRVSET 375
Cdd:PHA03247 2840 PPppgpPPPSLPLGGSVAPGGDVrrrpPSRSPAAKPAAPARPPVR-RLARPAVS-------RSTESFALPPDQPERPPQP 2911

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  376 CIVPAWLPSLPDEVFLEEAPlvRMRSPPDPHASQGPPASVHASDQPYGTGLGQRTGQVtVPTEYPLHECPGTAGADdcwq 455
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPPQPQP--PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL-VPGRVAVPRFRVPQPAP---- 2984

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  456 gvngsvgiSRPTSHTPTGTandniptidPTGLTTNPPTAAESDLLKPVPADALGLSGNDTPGPSHNTALARGTGQPGSRP 535
Cdd:PHA03247 2985 --------SREAPASSTPP---------LTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSDS 3047

                         490       500       510
                  ....*....|....*....|....*....|....
gi 530379692  536 TWPSqcleelVQELARLDPSLCDPLASQPSPEPP 569
Cdd:PHA03247 3048 ERSD------LEALDPLPPEPHDPFAHEPDPATP 3075
 
Name Accession Description Interval E-value
ASD2 pfam08687
Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which ...
 544-824 3.72e-91

Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.


Pssm-ID: 462561 [Multi-domain]  Cd Length: 290  Bit Score: 289.16  E-value: 3.72e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  544 ELVQELARLDPSLCDPLASQPSPEPPLGLLDGLIPlAEVRAAMRPACGEAG----------EEAASTFEPGSYQFSFTQL 613
Cdd:pfam08687   1 ELVKELVPKDKSLADILDPKPSRKTTMDLMEGLFP-EDTLRAMKPDLGEAYkkapseegseEEASGTSSLSSCSAYYTTS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  614 LPAPREETRLENPATHPVLDQPCGQGLPAPNNSIQGKKVELAARLQKMLQDLHTEQERLQGEAQAWARRQAALEAAVRQA 693
Cdd:pfam08687  80 APKAELLTKMKDLTTLPSPDQPEEQGEEELDNDLQQKKVELIESLQRKLQVLREEQEALQEEIQANAALGAEVEALVQEV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  694 CAPQELERFSRFMADLERVLGLLLLLGSRLARVRRALARAASDSDPDEQASLLQRLRLLQRQEEDAKELKEHVARRERAV 773
Cdd:pfam08687 160 CKPNELEKYRMFIGDLEKVVSLLLSLSGRLARVENALSSLDSDADAEERQSLLEKRRLLLRQLEDAKELKENLDRRERVV 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 530379692  774 REVLVRALPVEELRVYCALLAGKAAVLAQQRNLDERIRLLQDQLDAIRDDL 824
Cdd:pfam08687 240 SGILARYLTAEQLQDYRHFVKMKAALLIEQRELDEKIKLGEEQLKALKESL 290
ASD1 pfam08688
Apx/Shroom domain ASD1; This region is found in the actin binding protein Shroom which ...
 140-256 3.25e-13

Apx/Shroom domain ASD1; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure. ASD1 has been implicated directly in F-actin binding.


Pssm-ID: 462562 [Multi-domain]  Cd Length: 179  Bit Score: 68.52  E-value: 3.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  140 AYRQRLQGAQRRVLRETSFQRKELRMSLPAR--------------LRPTVPARPPATHPRSASLSHPGGEGEPARSRAPA 205
Cdd:pfam08688  40 AYREKLKDAQSRVLRATSFRRRDLQPSVPPVpwhlssrprpasahLRSPEAPISASPSPHTPRERHSVTPGDRLAGPPAV 119

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 530379692  206 PGTAGRGPLANQQRKWCFSEPGKLDRVGRGGGPareclgEACSSSGLPGPE 256
Cdd:pfam08688 120 RRIGGRKRLTAEQKKRSYSEPEKMNEVGVSPEP------EPAPAPHFMFPE 164
PHA03247 PHA03247
large tegument protein UL36; Provisional
 70-569 1.08e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692   70 PGPAPPDAALCTSPRPRPAVAARSgPQPTEVPGtPGPLNRQATPLLYALAAEAEAAAQAAEPPSPPASRAAyrQRLQGAQ 149
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDPPPPSPS-PAANEPDP-HPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS--SPPQRPR 2684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  150 RRVLRE-----TSFQRKELRMSLPA-RLRPTVPARPPATHPRSASLSHPGGEGEPARSRAPAPGTAGRGPLANQQRKWCF 223
Cdd:PHA03247 2685 RRAARPtvgslTSLADPPPPPPTPEpAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTA 2764

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  224 SEPGKLDRVGRGGGPARECLGEACSSSGLPGPEPLEFQHPAlakfeDHEVGWLPETQPQGSMNLDSGSLKLGDAFRPASR 303
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA-----DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  304 SR----SASGEVLGSWGGSGGTI----PIVQAVPQGAETPRPLFQtKLSRFLPQkeaavmyPAELPQSSPADSEQRVSET 375
Cdd:PHA03247 2840 PPppgpPPPSLPLGGSVAPGGDVrrrpPSRSPAAKPAAPARPPVR-RLARPAVS-------RSTESFALPPDQPERPPQP 2911

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  376 CIVPAWLPSLPDEVFLEEAPlvRMRSPPDPHASQGPPASVHASDQPYGTGLGQRTGQVtVPTEYPLHECPGTAGADdcwq 455
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPPQPQP--PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL-VPGRVAVPRFRVPQPAP---- 2984

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379692  456 gvngsvgiSRPTSHTPTGTandniptidPTGLTTNPPTAAESDLLKPVPADALGLSGNDTPGPSHNTALARGTGQPGSRP 535
Cdd:PHA03247 2985 --------SREAPASSTPP---------LTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSDS 3047

                         490       500       510
                  ....*....|....*....|....*....|....
gi 530379692  536 TWPSqcleelVQELARLDPSLCDPLASQPSPEPP 569
Cdd:PHA03247 3048 ERSD------LEALDPLPPEPHDPFAHEPDPATP 3075
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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