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Conserved domains on  [gi|530419108|ref|XP_005261126|]
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runt-related transcription factor 1 isoform X4 [Homo sapiens]

Protein Classification

Runt and RunxI domain-containing protein( domain architecture ID 10467269)

Runt and RunxI domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Runt pfam00853
Runt domain;
78-205 9.69e-101

Runt domain;


:

Pssm-ID: 459963  Cd Length: 129  Bit Score: 295.45  E-value: 9.69e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530419108   78 MVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVAR 157
Cdd:pfam00853   1 LVEVLADHPGELVRTGSPNFLCSVLPTHWRSNKSLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAVMKNQVAR 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 530419108  158 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRN 205
Cdd:pfam00853  81 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRS 128
RunxI pfam08504
Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription ...
325-416 6.51e-43

Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription factors and homologous proteins (AML, CBF-alpha, PEBP2). Its function might be to interact with functional cofactors.


:

Pssm-ID: 430037  Cd Length: 98  Bit Score: 145.86  E-value: 6.51e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530419108  325 SQAQGGPFQASSPSYHLYYGASAGSYQFSMV------GGERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNS 398
Cdd:pfam08504   1 PQNQSGPFQTNSPPYHLYYGTSSGSYQFSMVggsstsGGDRSPSRMLASCTNASTGSNLLNPNLGNQSDSVDADGSHSNS 80
                          90
                  ....*....|....*...
gi 530419108  399 PTNMAPSARLEEAVWRPY 416
Cdd:pfam08504  81 PTAMGTSGRMDEAVWRPY 98
 
Name Accession Description Interval E-value
Runt pfam00853
Runt domain;
78-205 9.69e-101

Runt domain;


Pssm-ID: 459963  Cd Length: 129  Bit Score: 295.45  E-value: 9.69e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530419108   78 MVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVAR 157
Cdd:pfam00853   1 LVEVLADHPGELVRTGSPNFLCSVLPTHWRSNKSLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAVMKNQVAR 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 530419108  158 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRN 205
Cdd:pfam00853  81 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRS 128
RunxI pfam08504
Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription ...
325-416 6.51e-43

Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription factors and homologous proteins (AML, CBF-alpha, PEBP2). Its function might be to interact with functional cofactors.


Pssm-ID: 430037  Cd Length: 98  Bit Score: 145.86  E-value: 6.51e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530419108  325 SQAQGGPFQASSPSYHLYYGASAGSYQFSMV------GGERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNS 398
Cdd:pfam08504   1 PQNQSGPFQTNSPPYHLYYGTSSGSYQFSMVggsstsGGDRSPSRMLASCTNASTGSNLLNPNLGNQSDSVDADGSHSNS 80
                          90
                  ....*....|....*...
gi 530419108  399 PTNMAPSARLEEAVWRPY 416
Cdd:pfam08504  81 PTAMGTSGRMDEAVWRPY 98
 
Name Accession Description Interval E-value
Runt pfam00853
Runt domain;
78-205 9.69e-101

Runt domain;


Pssm-ID: 459963  Cd Length: 129  Bit Score: 295.45  E-value: 9.69e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530419108   78 MVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVAR 157
Cdd:pfam00853   1 LVEVLADHPGELVRTGSPNFLCSVLPTHWRSNKSLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAVMKNQVAR 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 530419108  158 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRN 205
Cdd:pfam00853  81 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRS 128
RunxI pfam08504
Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription ...
325-416 6.51e-43

Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription factors and homologous proteins (AML, CBF-alpha, PEBP2). Its function might be to interact with functional cofactors.


Pssm-ID: 430037  Cd Length: 98  Bit Score: 145.86  E-value: 6.51e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530419108  325 SQAQGGPFQASSPSYHLYYGASAGSYQFSMV------GGERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNS 398
Cdd:pfam08504   1 PQNQSGPFQTNSPPYHLYYGTSSGSYQFSMVggsstsGGDRSPSRMLASCTNASTGSNLLNPNLGNQSDSVDADGSHSNS 80
                          90
                  ....*....|....*...
gi 530419108  399 PTNMAPSARLEEAVWRPY 416
Cdd:pfam08504  81 PTAMGTSGRMDEAVWRPY 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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