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Conserved domains on  [gi|530382607|ref|XP_005249460|]
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G patch domain and ankyrin repeat-containing protein 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 256-299 4.44e-13

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


:

Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 62.91  E-value: 4.44e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 530382607  256 SSPGFKLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYR 299
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
111-198 1.01e-10

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 1.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382607 111 AAQEGDLPELRRLLEpheaggAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAwVGVCELSGRDAAQLAEEAGFP 190
Cdd:COG0666  160 AAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAENGNL 232


                 ....*...
gi 530382607 191 EVARMVRE 198
Cdd:COG0666  233 EIVKLLLE 240
 
Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 256-299 4.44e-13

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 62.91  E-value: 4.44e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 530382607  256 SSPGFKLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYR 299
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 253-298 4.19e-12

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 60.25  E-value: 4.19e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 530382607   253 VPISSPGFKLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGY 298
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
111-198 1.01e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 1.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382607 111 AAQEGDLPELRRLLEpheaggAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAwVGVCELSGRDAAQLAEEAGFP 190
Cdd:COG0666  160 AAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAENGNL 232


                 ....*...
gi 530382607 191 EVARMVRE 198
Cdd:COG0666  233 EIVKLLLE 240
Ank_2 pfam12796
Ankyrin repeats (3 copies);
108-195 2.17e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.27  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382607  108 ILRAAQEGDLPELRRLLEpheaggAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAWvgvCELSGRDAAQLAEEA 187
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE------NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARS 71


                  ....*...
gi 530382607  188 GFPEVARM 195
Cdd:pfam12796  72 GHLEIVKL 79
 
Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 256-299 4.44e-13

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 62.91  E-value: 4.44e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 530382607  256 SSPGFKLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYR 299
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 253-298 4.19e-12

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 60.25  E-value: 4.19e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 530382607   253 VPISSPGFKLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGY 298
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
111-198 1.01e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 1.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382607 111 AAQEGDLPELRRLLEpheaggAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAwVGVCELSGRDAAQLAEEAGFP 190
Cdd:COG0666  160 AAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAENGNL 232


                 ....*...
gi 530382607 191 EVARMVRE 198
Cdd:COG0666  233 EIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-195 4.38e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.97  E-value: 4.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382607 108 ILRAAQEGDLPELRRLLEpheaggAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAwVGVCELSGRDAAQLAEEA 187
Cdd:COG0666   91 LHAAARNGDLEIVKLLLE------AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD-VNAQDNDGNTPLHLAAAN 163


                 ....*...
gi 530382607 188 GFPEVARM 195
Cdd:COG0666  164 GNLEIVKL 171
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-195 1.86e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 1.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382607 108 ILRAAQEGDLPELRRLLEpheaggAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAwVGVCELSGRDAAQLAEEA 187
Cdd:COG0666  124 LHLAAYNGNLEIVKLLLE------AGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD-VNARDNDGETPLHLAAEN 196


                 ....*...
gi 530382607 188 GFPEVARM 195
Cdd:COG0666  197 GHLEIVKL 204
Ank_2 pfam12796
Ankyrin repeats (3 copies);
108-195 2.17e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.27  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382607  108 ILRAAQEGDLPELRRLLEpheaggAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAWvgvCELSGRDAAQLAEEA 187
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE------NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARS 71


                  ....*...
gi 530382607  188 GFPEVARM 195
Cdd:pfam12796  72 GHLEIVKL 79
Ank_4 pfam13637
Ankyrin repeats (many copies);
104-163 3.60e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 3.60e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382607  104 MTHRILRAAQEGDLPELRRLLEpheaggAGGNINARDAFWWTPLMCAARAGQGAAVSYLL 163
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLE------KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
111-168 1.69e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.10  E-value: 1.69e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530382607 111 AAQEGDLPELRRLLEpheaggAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAA 168
Cdd:COG0666  193 AAENGHLEIVKLLLE------AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244
Ank_2 pfam12796
Ankyrin repeats (3 copies);
111-167 3.06e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.33  E-value: 3.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530382607  111 AAQEGDLPELRRLLEpheaggaGGNINARDAFWwTPLMCAARAGQGAAVSYLLGRGA 167
Cdd:pfam12796  37 AAKNGHLEIVKLLLE-------HADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGA 85
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
100-195 3.21e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.86  E-value: 3.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382607 100 AEDKMTHRILRAAQEGDLPELRRLLEpheagGAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAwVGVCELSGRD 179
Cdd:COG0666   49 LADALGALLLLAAALAGDLLVALLLL-----AAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD-VNARDKDGET 122

                         90
                 ....*....|....*.
gi 530382607 180 AAQLAEEAGFPEVARM 195
Cdd:COG0666  123 PLHLAAYNGNLEIVKL 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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