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Conserved domains on  [gi|530379299|ref|XP_005248561|]
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CD180 antigen isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_11 pfam18831
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 208-236 2.22e-11

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


:

Pssm-ID: 408601  Cd Length: 29  Bit Score: 58.62  E-value: 2.22e-11
                          10        20
                  ....*....|....*....|....*....
gi 530379299  208 STIFQSLNFGGTPNLSVIFNGLQNSTTQS 236
Cdd:pfam18831   1 SKVFQSLNFGGTLNLSVIFKGLQNSTIQS 29
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
262-540 2.93e-10

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.64  E-value: 2.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 262 SVESLNLQEHRFSDISSTTFQCfTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLcQISAANFPSLTHLYIRG 341
Cdd:COG4886  137 NLKELDLSNNQLTDLPEPLGNL-TNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 342 N-VKKLHLGvgcLEKLGNLQTLDLSHNDIEASDccslQLKNLSHLQTLNLSHNEPLGLQSQAfkECPQLELLDLAFTRL- 419
Cdd:COG4886  215 NqLTDLPEP---LANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLt 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 420 HINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSID 499
Cdd:COG4886  286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 530379299 500 QQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAAN 540
Cdd:COG4886  366 LLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
25-297 1.43e-08

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 1.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299  25 NCENLGLSEIPDTLPNTT--EFLEFSFNFLPTIhNRTFSRLMNLTFLDLTRCQINWIHEdTFQSHHQLSTLVLTGNPLIF 102
Cdd:COG4886  142 DLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 103 MAEtSLNGPKSLKHLFLIQTGISNLEFIpvHNLENLESLYLGSNHISSIkfPKDFPARNLKVLDFQNNAIHYISREDMRS 182
Cdd:COG4886  220 LPE-PLANLTNLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 183 LEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMS 262
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 530379299 263 VESLNLQEHRFSDISSTTFQCFTQLQELDLTATHL 297
Cdd:COG4886  375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 536-613 1.21e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 55.47  E-value: 1.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299   536 NLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKL---SC 612
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLldsGC 80


                   .
gi 530379299   613 G 613
Cdd:TIGR00864   81 D 81
 
Name Accession Description Interval E-value
LRR_11 pfam18831
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 208-236 2.22e-11

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408601  Cd Length: 29  Bit Score: 58.62  E-value: 2.22e-11
                          10        20
                  ....*....|....*....|....*....
gi 530379299  208 STIFQSLNFGGTPNLSVIFNGLQNSTTQS 236
Cdd:pfam18831   1 SKVFQSLNFGGTLNLSVIFKGLQNSTIQS 29
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
262-540 2.93e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.64  E-value: 2.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 262 SVESLNLQEHRFSDISSTTFQCfTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLcQISAANFPSLTHLYIRG 341
Cdd:COG4886  137 NLKELDLSNNQLTDLPEPLGNL-TNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 342 N-VKKLHLGvgcLEKLGNLQTLDLSHNDIEASDccslQLKNLSHLQTLNLSHNEPLGLQSQAfkECPQLELLDLAFTRL- 419
Cdd:COG4886  215 NqLTDLPEP---LANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLt 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 420 HINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSID 499
Cdd:COG4886  286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 530379299 500 QQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAAN 540
Cdd:COG4886  366 LLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-297 1.43e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 1.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299  25 NCENLGLSEIPDTLPNTT--EFLEFSFNFLPTIhNRTFSRLMNLTFLDLTRCQINWIHEdTFQSHHQLSTLVLTGNPLIF 102
Cdd:COG4886  142 DLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 103 MAEtSLNGPKSLKHLFLIQTGISNLEFIpvHNLENLESLYLGSNHISSIkfPKDFPARNLKVLDFQNNAIHYISREDMRS 182
Cdd:COG4886  220 LPE-PLANLTNLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 183 LEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMS 262
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 530379299 263 VESLNLQEHRFSDISSTTFQCFTQLQELDLTATHL 297
Cdd:COG4886  375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 295-488 6.18e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 6.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 295 THL----KGLPSgMKGLNLLKKL-VLSV--NHFDQLCQISaaNFPSLTHLYIRGNV-------------KKLHLGVGC-- 352
Cdd:cd21340    5 THLylndKNITK-IDNLSLCKNLkVLYLydNKITKIENLE--FLTNLTHLYLQNNQiekienlenlvnlKKLYLGGNRis 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 353 ----LEKLGNLQTLDLSHNDIE-----ASDCCSLQlkNLSH-LQTLNLSHNeplglqsqafkecpqlelldlaftrlHIN 422
Cdd:cd21340   82 vvegLENLTNLEELHIENQRLPpgeklTFDPRSLA--ALSNsLRVLNISGN--------------------------NID 133

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530379299 423 APqSPFQNLHFLQVLNLTYCFLDTSNQ--HLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVL 488
Cdd:cd21340  134 SL-EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVL 200
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 536-613 1.21e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 55.47  E-value: 1.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299   536 NLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKL---SC 612
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLldsGC 80


                   .
gi 530379299   613 G 613
Cdd:TIGR00864   81 D 81
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 106-456 2.03e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 2.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 106 TSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNaihYISREDMRSLEQ 185
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDN---SLSGEIPELVIQ 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 186 AINLS-LNFNGNNVKGIELGAFDS----TIFQ--SLNF-GGTP-------NLSVI---FNGLQNSTTQSLW-------LG 240
Cdd:PLN00113 307 LQNLEiLHLFSNNFTGKIPVALTSlprlQVLQlwSNKFsGEIPknlgkhnNLTVLdlsTNNLTGEIPEGLCssgnlfkLI 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 241 TFEDIDDEDISSAMlkGLCEmSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKG-LPSGMKGLNLLKKLVLSVNH 319
Cdd:PLN00113 387 LFSNSLEGEIPKSL--GACR-SLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGrINSRKWDMPSLQMLSLARNK 463

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 320 FdqlcqisaanFPSLTHLYIRGNVKKLHLGVG--------CLEKLGNLQTLDLSHNDIeaSDCCSLQLKNLSHLQTLNLS 391
Cdd:PLN00113 464 F----------FGGLPDSFGSKRLENLDLSRNqfsgavprKLGSLSELMQLKLSENKL--SGEIPDELSSCKKLVSLDLS 531

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530379299 392 HNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVlnltycflDTSNQHLLAGLP 456
Cdd:PLN00113 532 HNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQV--------NISHNHLHGSLP 588
LRR_8 pfam13855
Leucine rich repeat;
484-542 3.03e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 3.03e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299  484 SLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI-YLNLAANSI 542
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLrYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
16-172 3.07e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.47  E-value: 3.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299  16 EKKEAN-KTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNltfLDLTRCQINWIHEDTFQshhQLSTLV 94
Cdd:PRK15370 216 ENLQGNiKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQS---LDLFHNKISCLPENLPE---ELRYLS 289

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530379299  95 LTGNPLIFMAEtslNGPKSLKHLFLIQtgiSNLEFIPVHNLENLESLYLGSNHISSIkfPKDFPARnLKVLDFQNNAI 172
Cdd:PRK15370 290 VYDNSIRTLPA---HLPSGITHLNVQS---NSLTALPETLPPGLKTLEAGENALTSL--PASLPPE-LQVLDVSKNQI 358
LRRCT smart00082
Leucine rich repeat C-terminal domain;
564-613 1.43e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.43e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530379299   564 NPLDCTCSNIHFLTWYKENLHkLEGSEETTCANPPSLRG--VKLSDVKLSCG 613
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEH-LQDPVDLRCASPSSLRGplLELLHSEFKCP 51
 
Name Accession Description Interval E-value
LRR_11 pfam18831
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 208-236 2.22e-11

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408601  Cd Length: 29  Bit Score: 58.62  E-value: 2.22e-11
                          10        20
                  ....*....|....*....|....*....
gi 530379299  208 STIFQSLNFGGTPNLSVIFNGLQNSTTQS 236
Cdd:pfam18831   1 SKVFQSLNFGGTLNLSVIFKGLQNSTIQS 29
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
262-540 2.93e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.64  E-value: 2.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 262 SVESLNLQEHRFSDISSTTFQCfTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLcQISAANFPSLTHLYIRG 341
Cdd:COG4886  137 NLKELDLSNNQLTDLPEPLGNL-TNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 342 N-VKKLHLGvgcLEKLGNLQTLDLSHNDIEASDccslQLKNLSHLQTLNLSHNEPLGLQSQAfkECPQLELLDLAFTRL- 419
Cdd:COG4886  215 NqLTDLPEP---LANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLt 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 420 HINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSID 499
Cdd:COG4886  286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 530379299 500 QQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAAN 540
Cdd:COG4886  366 LLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
329-564 2.84e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 2.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 329 ANFPSLTHLYIRGNvkKLHLGVGCLEKLGNLQTLDLSHNDIEASDccsLQLKNLSHLQTLNLSHNEPLGLqSQAFKECPQ 408
Cdd:COG4886  110 SNLTNLESLDLSGN--QLTDLPEELANLTNLKELDLSNNQLTDLP---EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTN 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 409 LELLDLAFTRlhINAPQSPFQNLHFLQVLNLTYCFLdTSNQHLLAGLPVLRHLNLKGNHfqdgtITKTNLLQTVGSLEVL 488
Cdd:COG4886  184 LKELDLSNNQ--ITDLPEPLGNLTNLEELDLSGNQL-TDLPEPLANLTNLETLDLSNNQ-----LTDLPELGNLTNLEEL 255

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530379299 489 ILSSCGLLSIDQQAfhSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHN 564
Cdd:COG4886  256 DLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-297 1.43e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 1.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299  25 NCENLGLSEIPDTLPNTT--EFLEFSFNFLPTIhNRTFSRLMNLTFLDLTRCQINWIHEdTFQSHHQLSTLVLTGNPLIF 102
Cdd:COG4886  142 DLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 103 MAEtSLNGPKSLKHLFLIQTGISNLEFIpvHNLENLESLYLGSNHISSIkfPKDFPARNLKVLDFQNNAIHYISREDMRS 182
Cdd:COG4886  220 LPE-PLANLTNLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 183 LEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMS 262
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 530379299 263 VESLNLQEHRFSDISSTTFQCFTQLQELDLTATHL 297
Cdd:COG4886  375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 295-488 6.18e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 6.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 295 THL----KGLPSgMKGLNLLKKL-VLSV--NHFDQLCQISaaNFPSLTHLYIRGNV-------------KKLHLGVGC-- 352
Cdd:cd21340    5 THLylndKNITK-IDNLSLCKNLkVLYLydNKITKIENLE--FLTNLTHLYLQNNQiekienlenlvnlKKLYLGGNRis 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 353 ----LEKLGNLQTLDLSHNDIE-----ASDCCSLQlkNLSH-LQTLNLSHNeplglqsqafkecpqlelldlaftrlHIN 422
Cdd:cd21340   82 vvegLENLTNLEELHIENQRLPpgeklTFDPRSLA--ALSNsLRVLNISGN--------------------------NID 133

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530379299 423 APqSPFQNLHFLQVLNLTYCFLDTSNQ--HLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVL 488
Cdd:cd21340  134 SL-EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVL 200
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 536-613 1.21e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 55.47  E-value: 1.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299   536 NLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKL---SC 612
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLldsGC 80


                   .
gi 530379299   613 G 613
Cdd:TIGR00864   81 D 81
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 106-456 2.03e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 2.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 106 TSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNaihYISREDMRSLEQ 185
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDN---SLSGEIPELVIQ 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 186 AINLS-LNFNGNNVKGIELGAFDS----TIFQ--SLNF-GGTP-------NLSVI---FNGLQNSTTQSLW-------LG 240
Cdd:PLN00113 307 LQNLEiLHLFSNNFTGKIPVALTSlprlQVLQlwSNKFsGEIPknlgkhnNLTVLdlsTNNLTGEIPEGLCssgnlfkLI 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 241 TFEDIDDEDISSAMlkGLCEmSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKG-LPSGMKGLNLLKKLVLSVNH 319
Cdd:PLN00113 387 LFSNSLEGEIPKSL--GACR-SLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGrINSRKWDMPSLQMLSLARNK 463

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 320 FdqlcqisaanFPSLTHLYIRGNVKKLHLGVG--------CLEKLGNLQTLDLSHNDIeaSDCCSLQLKNLSHLQTLNLS 391
Cdd:PLN00113 464 F----------FGGLPDSFGSKRLENLDLSRNqfsgavprKLGSLSELMQLKLSENKL--SGEIPDELSSCKKLVSLDLS 531

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530379299 392 HNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVlnltycflDTSNQHLLAGLP 456
Cdd:PLN00113 532 HNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQV--------NISHNHLHGSLP 588
LRR_8 pfam13855
Leucine rich repeat;
484-542 3.03e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 3.03e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299  484 SLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI-YLNLAANSI 542
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLrYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
16-172 3.07e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.47  E-value: 3.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299  16 EKKEAN-KTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNltfLDLTRCQINWIHEDTFQshhQLSTLV 94
Cdd:PRK15370 216 ENLQGNiKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQS---LDLFHNKISCLPENLPE---ELRYLS 289

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530379299  95 LTGNPLIFMAEtslNGPKSLKHLFLIQtgiSNLEFIPVHNLENLESLYLGSNHISSIkfPKDFPARnLKVLDFQNNAI 172
Cdd:PRK15370 290 VYDNSIRTLPA---HLPSGITHLNVQS---NSLTALPETLPPGLKTLEAGENALTSL--PASLPPE-LQVLDVSKNQI 358
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-481 3.81e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 3.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299   5 LLRVSSADEKSEKKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCqinwiheDTF 84
Cdd:COG4886   37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EEL 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299  85 QSHHQLSTLVLTGNPLifmaeTSLngPKSLKhlfliqtgisnlefipvhNLENLESLYLGSNHISSIkfPKDFPA-RNLK 163
Cdd:COG4886  110 SNLTNLESLDLSGNQL-----TDL--PEELA------------------NLTNLKELDLSNNQLTDL--PEPLGNlTNLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 164 VLDFQNNAIHYISREdmrsleqainlslnfngnnvkgielgafdstifqslnFGGTPNLsvifnglqnsttqslwlgtfe 243
Cdd:COG4886  163 SLDLSNNQLTDLPEE-------------------------------------LGNLTNL--------------------- 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 244 diddedissamlkglcemsvESLNLQEHRFSDISStTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQL 323
Cdd:COG4886  185 --------------------KELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 324 CQIsaANFPSLTHLYIRGNVKKlhlGVGCLEKLGNLQTLDLSHNDIEasdccSLQLKNLSHLQTLNLSHNEPLGLQSQAF 403
Cdd:COG4886  244 PEL--GNLTNLEELDLSNNQLT---DLPPLANLTNLKTLDLSNNQLT-----DLKLKELELLLGLNSLLLLLLLLNLLEL 313

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530379299 404 KECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQT 481
Cdd:COG4886  314 LILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
LRR_8 pfam13855
Leucine rich repeat;
407-468 7.12e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 7.12e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530379299  407 PQLELLDLAFTRLHiNAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHF 468
Cdd:pfam13855   1 PNLRSLDLSNNRLT-SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
564-613 1.43e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.43e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530379299   564 NPLDCTCSNIHFLTWYKENLHkLEGSEETTCANPPSLRG--VKLSDVKLSCG 613
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEH-LQDPVDLRCASPSSLRGplLELLHSEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 332-413 1.82e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 332 PSLTHLYIRGNvkklHLG-VGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNePLGLQSQAFKE----C 406
Cdd:cd21340  120 NSLRVLNISGN----NIDsLEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN-PVCKKPKYRDKiilaS 194


                 ....*..
gi 530379299 407 PQLELLD 413
Cdd:cd21340  195 KSLEVLD 201
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 314-528 1.99e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 1.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 314 VLSVNHFDQLCQISAANfPSLTHLYIRGN-----VKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQ-LKNLSHLQT 387
Cdd:cd00116   34 TLGEEAAKALASALRPQ-PSLKELCLSLNetgriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLEsLLRSSSLQE 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 388 LNLSHNE----PLGLQSQAFKEC-PQLELLDLAFTRLHiNAPQSP----FQNLHFLQVLNLTY-CFLDTSNQHLLAGLPV 457
Cdd:cd00116  113 LKLNNNGlgdrGLRLLAKGLKDLpPALEKLVLGRNRLE-GASCEAlakaLRANRDLKELNLANnGIGDAGIRALAEGLKA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 458 ---LRHLNLKGNHFQD-GTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSH-----VDLSHNSLTCDSIDSLS 528
Cdd:cd00116  192 ncnLEVLDLNNNGLTDeGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNislltLSLSCNDITDDGAKDLA 271
LRR_8 pfam13855
Leucine rich repeat;
310-369 2.62e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 2.62e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299  310 LKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKlHLGVGCLEKLGNLQTLDLSHNDI 369
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 113-566 3.72e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 3.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 113 SLKHLFLiqtgiSNLEF---IPVHNLENLESLYLgSNHISSIKFPKDFPA-RNLKVLDFQNNAIH---YISREDMRSLEq 185
Cdd:PLN00113 119 SLRYLNL-----SNNNFtgsIPRGSIPNLETLDL-SNNMLSGEIPNDIGSfSSLKVLDLGGNVLVgkiPNSLTNLTSLE- 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 186 ainlSLNFNGNNVKG---IELGAFDSTIFQSLNF----GGTPN----------LSVIFNGLQNSTTQSLwlGTFEDIdde 248
Cdd:PLN00113 192 ----FLTLASNQLVGqipRELGQMKSLKWIYLGYnnlsGEIPYeiggltslnhLDLVYNNLTGPIPSSL--GNLKNL--- 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 249 dissamlkglcemsvESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKG-LPSGMKGLNLLKKLVLSVNHFDQLCQIS 327
Cdd:PLN00113 263 ---------------QYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGeIPELVIQLQNLEILHLFSNNFTGKIPVA 327

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 328 AANFPSLTHLYIRGNvkKLHLGV-GCLEKLGNLQTLDLSHND----IEASDCCSLQL---------------KNLSHLQT 387
Cdd:PLN00113 328 LTSLPRLQVLQLWSN--KFSGEIpKNLGKHNNLTVLDLSTNNltgeIPEGLCSSGNLfklilfsnslegeipKSLGACRS 405

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 388 LN---LSHNEPLGLQSQAFKECPQLELLDLAFTRLHINApQSPFQNLHFLQVLNLtycfldtSNQHLLAGLP------VL 458
Cdd:PLN00113 406 LRrvrLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRI-NSRKWDMPSLQMLSL-------ARNKFFGGLPdsfgskRL 477

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 459 RHLNLKGNHFQdGTITKTnlLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI-YLNL 537
Cdd:PLN00113 478 ENLDLSRNQFS-GAVPRK--LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLsQLDL 554

                        490       500
                 ....*....|....*....|....*....
gi 530379299 538 AANSINIISPRLLPILSQQSTINLSHNPL 566
Cdd:PLN00113 555 SQNQLSGEIPKNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
358-419 4.37e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 4.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530379299  358 NLQTLDLSHNDIEASDccSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRL 419
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 382-459 8.47e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 8.47e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530379299 382 LSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQnLHFLQVLNLTYCFLDTSNQHLLAGLPVLR 459
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQ-LTSLRILNLNGNSLSGRVPAALGGRLLHR 517
LRR_8 pfam13855
Leucine rich repeat;
332-393 1.38e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.38e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530379299  332 PSLTHLYIRGNvKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQlkNLSHLQTLNLSHN 393
Cdd:pfam13855   1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS--GLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 331-542 2.46e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 331 FPSLTHLYIRGN-VKKLhlgvGCLEKLGNLQTLDLSHNDIEasdccSLQ-LKNLSHLQTLNLSHNEplglqsqafkecpq 408
Cdd:cd21340   23 CKNLKVLYLYDNkITKI----ENLEFLTNLTHLYLQNNQIE-----KIEnLENLVNLKKLYLGGNR-------------- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 409 lelldlaFTRLhinapqSPFQNLHFLQVLNLtycfldtSNQHLLAGLPVLrhlnlkgnhFQDGTITKTnllqtVGSLEVL 488
Cdd:cd21340   80 -------ISVV------EGLENLTNLEELHI-------ENQRLPPGEKLT---------FDPRSLAAL-----SNSLRVL 125

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530379299 489 ILSSCGLLSIDQqaFHSLGKMSHVDLSHNSLT-----CDSIDSLSHLKgiYLNLAANSI 542
Cdd:cd21340  126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISdleelLDLLSSWPSLR--ELDLTGNPV 180
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 310-419 8.66e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.88  E-value: 8.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379299 310 LKKLVLSVNH-----FDQLCQISAANfPSLTHLYIRGNVKKlHLGV----GCLEKLGNLQTLDLSHNDIEASDCCSL--Q 378
Cdd:cd00116  167 LKELNLANNGigdagIRALAEGLKAN-CNLEVLDLNNNGLT-DEGAsalaETLASLKSLEVLNLGDNNLTDAGAAALasA 244

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 530379299 379 LKNLSH-LQTLNLSHNE--PLGLQS--QAFKECPQLELLDLAFTRL 419
Cdd:cd00116  245 LLSPNIsLLTLSLSCNDitDDGAKDlaEVLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
285-342 8.81e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 8.81e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530379299  285 TQLQELDLTATHLKGLPSGM-KGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGN 342
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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