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Conserved domains on  [gi|528998476|ref|XP_005221705|]
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carboxymethylenebutenolidase homolog isoform X1 [Bos taurus]

Protein Classification

dienelactone hydrolase family protein( domain architecture ID 10785456)

dienelactone hydrolase family protein plays a crucial role in chlorocatechol degradation via the modified ortho cleavage pathway

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917
SCOP:  3000102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
30-242 6.69e-44

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 147.42  E-value: 6.69e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476  30 IKAYLTKsPVDAGK--AVVVIQDIFGWQlPNTRYMADMIAGNGYTTIVPDFFVGQEPWHPSGDWStfpEWLKTRNARKID 107
Cdd:COG0412   16 LPGYLAR-PAGGGPrpGVVVLHEIFGLN-PHIRDVARRLAAAGYVVLAPDLYGRGGPGDDPDEAR---ALMGALDPELLA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476 108 KEFDAVLKYLKQQ--CHTKRIGVVGFCWGGTAVHHLMLKHPELRAGVSVYG--IIKDAEDVYG-LKNPTLFIFAENDAVI 182
Cdd:COG0412   91 ADLRAALDWLKAQpeVDAGRVGVVGFCFGGGLALLAAARGPDLAAAVSFYGglPADDLLDLAArIKAPVLLLYGEKDPLV 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476 183 PLEQVSLLTQKLKEHcKVEYQIKTFSGQTHGFVHRKREDCSPEDKpyiDEARRNLLEWLN 242
Cdd:COG0412  171 PPEQVAALEAALAAA-GVDVELHVYPGAGHGFTNPGRPRYDPAAA---EDAWQRTLAFLA 226
 
Name Accession Description Interval E-value
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
30-242 6.69e-44

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 147.42  E-value: 6.69e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476  30 IKAYLTKsPVDAGK--AVVVIQDIFGWQlPNTRYMADMIAGNGYTTIVPDFFVGQEPWHPSGDWStfpEWLKTRNARKID 107
Cdd:COG0412   16 LPGYLAR-PAGGGPrpGVVVLHEIFGLN-PHIRDVARRLAAAGYVVLAPDLYGRGGPGDDPDEAR---ALMGALDPELLA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476 108 KEFDAVLKYLKQQ--CHTKRIGVVGFCWGGTAVHHLMLKHPELRAGVSVYG--IIKDAEDVYG-LKNPTLFIFAENDAVI 182
Cdd:COG0412   91 ADLRAALDWLKAQpeVDAGRVGVVGFCFGGGLALLAAARGPDLAAAVSFYGglPADDLLDLAArIKAPVLLLYGEKDPLV 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476 183 PLEQVSLLTQKLKEHcKVEYQIKTFSGQTHGFVHRKREDCSPEDKpyiDEARRNLLEWLN 242
Cdd:COG0412  171 PPEQVAALEAALAAA-GVDVELHVYPGAGHGFTNPGRPRYDPAAA---EDAWQRTLAFLA 226
DLH pfam01738
Dienelactone hydrolase family;
32-242 7.76e-33

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 118.61  E-value: 7.76e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476   32 AYLTKSPVDAGKAVVVIQDIFGWQlPNTRYMADMIAGNGYTTIVPDFFVGQ-EPWHPSGDWSTFPEWLKTRNARKIDKEF 110
Cdd:pfam01738   2 AYLATPKNPPWPVVVVFQEIFGVN-DNIREIADRLADEGYVALAPDLYFRQgDPNDEADAARAMFELVSKRVMEKVLDDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476  111 DAVLKYLKQQ--CHTKRIGVVGFCWGGTAVHHLMLKHPELRAGVSVYGI--IKDAEDVYGLKNPTLFIFAENDAVIPLEQ 186
Cdd:pfam01738  81 EAAVNYLKSQpeVSPKKVGVVGYCMGGALAVLLAAKGPLVDAAVGFYGVgpEPPLIEAPDIKAPILFHFGEEDHFVPADS 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 528998476  187 VSLLTQKLKEHcKVEYQIKTFSGQTHGFVHRKREDCSPEDKpyiDEARRNLLEWLN 242
Cdd:pfam01738 161 RELIEEALKAA-NVDHQIHSYPGAGHAFANDSRPSYNAAAA---EDAWERTLEFFK 212
 
Name Accession Description Interval E-value
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
30-242 6.69e-44

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 147.42  E-value: 6.69e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476  30 IKAYLTKsPVDAGK--AVVVIQDIFGWQlPNTRYMADMIAGNGYTTIVPDFFVGQEPWHPSGDWStfpEWLKTRNARKID 107
Cdd:COG0412   16 LPGYLAR-PAGGGPrpGVVVLHEIFGLN-PHIRDVARRLAAAGYVVLAPDLYGRGGPGDDPDEAR---ALMGALDPELLA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476 108 KEFDAVLKYLKQQ--CHTKRIGVVGFCWGGTAVHHLMLKHPELRAGVSVYG--IIKDAEDVYG-LKNPTLFIFAENDAVI 182
Cdd:COG0412   91 ADLRAALDWLKAQpeVDAGRVGVVGFCFGGGLALLAAARGPDLAAAVSFYGglPADDLLDLAArIKAPVLLLYGEKDPLV 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476 183 PLEQVSLLTQKLKEHcKVEYQIKTFSGQTHGFVHRKREDCSPEDKpyiDEARRNLLEWLN 242
Cdd:COG0412  171 PPEQVAALEAALAAA-GVDVELHVYPGAGHGFTNPGRPRYDPAAA---EDAWQRTLAFLA 226
DLH pfam01738
Dienelactone hydrolase family;
32-242 7.76e-33

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 118.61  E-value: 7.76e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476   32 AYLTKSPVDAGKAVVVIQDIFGWQlPNTRYMADMIAGNGYTTIVPDFFVGQ-EPWHPSGDWSTFPEWLKTRNARKIDKEF 110
Cdd:pfam01738   2 AYLATPKNPPWPVVVVFQEIFGVN-DNIREIADRLADEGYVALAPDLYFRQgDPNDEADAARAMFELVSKRVMEKVLDDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476  111 DAVLKYLKQQ--CHTKRIGVVGFCWGGTAVHHLMLKHPELRAGVSVYGI--IKDAEDVYGLKNPTLFIFAENDAVIPLEQ 186
Cdd:pfam01738  81 EAAVNYLKSQpeVSPKKVGVVGYCMGGALAVLLAAKGPLVDAAVGFYGVgpEPPLIEAPDIKAPILFHFGEEDHFVPADS 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 528998476  187 VSLLTQKLKEHcKVEYQIKTFSGQTHGFVHRKREDCSPEDKpyiDEARRNLLEWLN 242
Cdd:pfam01738 161 RELIEEALKAA-NVDHQIHSYPGAGHAFANDSRPSYNAAAA---EDAWERTLEFFK 212
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
30-245 2.78e-17

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 78.13  E-value: 2.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476  30 IKAYLTKsPVDAGK--AVVVIQDIFGWQLPNTRYMADMIAGNGYTTIVPDFF-VGQEPwhpsGDWSTFPEWlktrnarki 106
Cdd:COG1506   10 LPGWLYL-PADGKKypVVVYVHGGPGSRDDSFLPLAQALASRGYAVLAPDYRgYGESA----GDWGGDEVD--------- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476 107 dkEFDAVLKYLKQQ--CHTKRIGVVGFCWGGTAVHHLMLKHPEL-RAGVSVYGII--------------------KDAED 163
Cdd:COG1506   76 --DVLAAIDYLAARpyVDPDRIGIYGHSYGGYMALLAAARHPDRfKAAVALAGVSdlrsyygttreyterlmggpWEDPE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476 164 VY----------GLKNPTLFIFAENDAVIPLEQVSLLTQKLKEHcKVEYQIKTFSGQTHGFVhrkredcspedKPYIDEA 233
Cdd:COG1506  154 AYaarsplayadKLKTPLLLIHGEADDRVPPEQAERLYEALKKA-GKPVELLVYPGEGHGFS-----------GAGAPDY 221

                        250
                 ....*....|..
gi 528998476 234 RRNLLEWLNKYV 245
Cdd:COG1506  222 LERILDFLDRHL 233
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
38-243 6.34e-10

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 57.32  E-value: 6.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476  38 PVDAGKAVVVIqdIFGWQLPNTRY--MADMIAGNGYTTIVPDFfvgqePWH-----PSGDWSTFPEWLKtrnarkidkEF 110
Cdd:COG2267   23 PAGSPRGTVVL--VHGLGEHSGRYaeLAEALAAAGYAVLAFDL-----RGHgrsdgPRGHVDSFDDYVD---------DL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476 111 DAVLKYLKQQcHTKRIGVVGFCWGGTAVHHLMLKHPE-LRAGVSV-------------YGIIKD---AEDVYGLKNPTLF 173
Cdd:COG2267   87 RAALDALRAR-PGLPVVLLGHSMGGLIALLYAARYPDrVAGLVLLapayradpllgpsARWLRAlrlAEALARIDVPVLV 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476 174 IFAENDAVIPLEQVSLLTQKLKEHCkveyQIKTFSGQTHGFVHRkredcspedkPYIDEARRNLLEWLNK 243
Cdd:COG2267  166 LHGGADRVVPPEAARRLAARLSPDV----ELVLLPGARHELLNE----------PAREEVLAAILAWLER 221
FSH1 pfam03959
Serine hydrolase (FSH1); This is a family of serine hydrolases.
 104-199 1.45e-05

Serine hydrolase (FSH1); This is a family of serine hydrolases.


Pssm-ID: 461110  Cd Length: 208  Bit Score: 44.58  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476  104 RKIDKEFDAVLKYLKQQ--CHtkriGVVGFCWGGTAV--------HHLMLKHPELRAGVSVYG------IIKDAEDVYGL 167
Cdd:pfam03959  82 LGLDESLDYVRDYIKENgpFD----GILGFSQGAALAailaslleEGLPLSHPPLKFAILFSGfrprppIYQEYYSEDPI 157

                          90       100       110
                  ....*....|....*....|....*....|..
gi 528998476  168 KNPTLFIFAENDAVIPLEqvslLTQKLKEHCK 199
Cdd:pfam03959 158 QTPSLHVIGELDTVVPEE----RSEKLAEACK 185
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
112-218 5.87e-05

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 42.84  E-value: 5.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476 112 AVLKYLKQQcHTKRIGVVGFCWGGTAVHHLMLKHPELRAGVSV------YgiikDAEDVYGLKNPTLFIFAENDAVIPLE 185
Cdd:COG2945   85 AALDWLRAQ-NPLPLWLAGFSFGAYVALQLAMRLPEVEGLILVappvnrY----DFSFLAPCPAPTLVIHGEQDEVVPPA 159

                         90       100       110
                 ....*....|....*....|....*....|...
gi 528998476 186 QVSLLTQKLKEHCKVEyqikTFSGQTHgFVHRK 218
Cdd:COG2945  160 EVLDWARPLSPPLPVV----VVPGADH-FFHGK 187
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 63-244 7.46e-05

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 42.98  E-value: 7.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476  63 ADMIAGNGYTTIVPDF-FVGQepwhpSGDWSTFPEWLKTRNARkidkefdAVLKYLKQQC--HTKRIGVVGFC-WGGTAV 138
Cdd:COG1073   57 AQRLAELGFNVLAFDYrGYGE-----SEGEPREEGSPERRDAR-------AAVDYLRTLPgvDPERIGLLGISlGGGYAL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476 139 HHLMLkHPELRA--GVSVYGIIKDA-----EDVYG------------------------------LKNPTLFIFAENDAV 181
Cdd:COG1073  125 NAAAT-DPRVKAviLDSPFTSLEDLaaqraKEARGaylpgvpylpnvrlasllndefdplakiekISRPLLFIHGEKDEA 203

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528998476 182 IPLEqvslLTQKLKEHCKVEYQIKTFSGQTHGFVHRKREdcspedkpyiDEARRNLLEWLNKY 244
Cdd:COG1073  204 VPFY----MSEDLYEAAAEPKELLIVPGAGHVDLYDRPE----------EEYFDKLAEFFKKN 252
YpfH COG0400
Predicted esterase [General function prediction only];
62-241 9.18e-05

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 42.20  E-value: 9.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476  62 MADMIAGNGYTTIVPDffvGQEPWHPSGD-WSTFPEWLKTRNARKID---KEFDAVLKYLKQQCH--TKRIGVVGFCWGG 135
Cdd:COG0400   24 LAPELALPGAAVLAPR---APVPEGPGGRaWFDLSFLEGREDEEGLAaaaEALAAFIDELEARYGidPERIVLAGFSQGA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476 136 TAVHHLMLKHPELRAGV-----SVYGIIKDAEDVYGLKNPTLFIFA-ENDAVIPLEQVSLLTQKLKEH-CKVEYQIktFS 208
Cdd:COG0400  101 AMALSLALRRPELLAGVvalsgYLPGEEALPAPEAALAGTPVFLAHgTQDPVIPVERAREAAEALEAAgADVTYRE--YP 178

                        170       180       190
                 ....*....|....*....|....*....|...
gi 528998476 209 GQtHGFvhrkredcSPEDkpyIDEARRNLLEWL 241
Cdd:COG0400  179 GG-HEI--------SPEE---LADARAWLAERL 199
COG4099 COG4099
Predicted peptidase [General function prediction only];
87-244 1.11e-04

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 42.26  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476  87 PSGDWstfpeWlktrNARKIDKEFDAVLKYLKQQCH--TKRIGVVGFCWGGTAVHHLMLKHPEL-RAGVSVYGIIkDAED 163
Cdd:COG4099   95 PEDDY-----W----SDTKALDAVLALLDDLIAEYRidPDRIYLTGLSMGGYGTWDLAARYPDLfAAAVPICGGG-DPAN 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476 164 VYGLKNPTLFIF-AENDAVIPLEQVSLLTQKLKEHC-KVEYQIktFSGQTHGfvhrkredcsPEDKPYIDEarrNLLEWL 241
Cdd:COG4099  165 AANLKKVPVWIFhGAKDDVVPVEESRAMVEALKAAGaDVKYTE--YPGVGHN----------SWDPAYANP---DLYDWL 229


                 ...
gi 528998476 242 NKY 244
Cdd:COG4099  230 FAQ 232
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
60-154 1.46e-04

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 41.85  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476  60 RYMADMIAGNGYTTIVPDFfvgqePWHpSGDW-----STFPEWLKtrnarkidkEFDAVLKYLKQQChtKRIGVVGFCWG 134
Cdd:COG1647   32 RPLAEALAKAGYTVYAPRL-----PGH-GTSPedllkTTWEDWLE---------DVEEAYEILKAGY--DKVIVIGLSMG 94

                         90       100
                 ....*....|....*....|
gi 528998476 135 GTAVHHLMLKHPELRAGVSV 154
Cdd:COG1647   95 GLLALLLAARYPDVAGLVLL 114
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 43-154 1.79e-04

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 41.72  E-value: 1.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528998476   43 KAVVVIQDIFGWqLPNTRYMADMIAGNGYTTIVPDffvgqepwHPSGDWSTFPEWLKTRNARKIDKEFDAVLKYLKQQch 122
Cdd:pfam00561   1 PPVLLLHGLPGS-SDLWRKLAPALARDGFRVIALD--------LRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLE-- 69

                          90       100       110
                  ....*....|....*....|....*....|...
gi 528998476  123 tkRIGVVGFCWGGTAVHHLMLKHPEL-RAGVSV 154
Cdd:pfam00561  70 --KVNLVGHSMGGLIALAYAAKYPDRvKALVLL 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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