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Conserved domains on  [gi|1387196432|ref|XP_005211967|]
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protein TALPID3 isoform X3 [Bos taurus]

Protein Classification

TALPID3 domain-containing protein( domain architecture ID 12173090)

TALPID3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 134-1378 0e+00

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


:

Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 1830.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  134 DIFISQYTVGQKDALRAVLKQKTQSMPVFKEVKVQLLEDAGTEKDPVTQENRISPSGIDSATTVAAATAAAIAAAAPLIK 213
Cdd:pfam15324    1 DIFISQYSAGQKDAVRAVLKQRAQSAPVFKEVKVQLLDDACSEKDAVGPEVQPSPSGIDSATTVAAATAAAIATTAPLIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  214 VQSELEAKVNSVTELLNKLQETDKQLQRVTEQQTTMQNKQETLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQAHFISA 293
Cdd:pfam15324   81 VQSDLEAKVNSVSELLKKLQETDKQLQRVTEQQTSIQAKQEKSCCHDHEKQMNAFMEQRLRHLEKIQQQQIDIQTHLIGS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  294 ALKTSSFQPVTVPPSRAVEKYSV-KPDRLNFGSSNLSSHNVFTSKQAPSREVEDTSFDKQRSPLETPAPRRFAPVPVSKD 372
Cdd:pfam15324  161 ALKAVSLQPSSVTSSRAVEKSGNsSEDESPAVGSASTSHHTFAPKQAPLAEVRDTQFDRQKSPLETPAPRRFAPVPVSRD 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  373 DKISKKENPIEEKENMELSCHAGSVGFLEQILNNHDSLTRISESSDKTSLARSKMGWNPERRNSLDTIATQRFPSCEELG 452
Cdd:pfam15324  241 AKISKREPPKEEKENMETSSSKGNGRLLEQILNNQDSPTRKSESSVVTSLAMATVGWQPERSRESQPLEPQSFPSSEEPE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  453 TAKVTVQKSDDI-HELDQKRKETNSILQLKE------------------SQMSGLADLP------------------QNS 495
Cdd:pfam15324  321 TASVTVQKASDVlQDLGQLKKEMRSLLQTADafpvpnakstrssqssrsLSPLPTPPPPppapismppvtavslaalSSP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  496 VKLQITN-TRSVLKDAEKILRGVQNNKKVLEENLEAIIRAKDGAAMYSFINALSNNREISEKIRIKKTVDDWIKTISAEI 574
Cdd:pfam15324  401 SVLQSTQpPRSMLKDAEKILRQVQNNKKVLEENLEAIIRAKDGAALHSFINALSTNRDMSEEIRIRKTVDEWIKTISKEI 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  575 QDELTRKDYEQKRFDQKNERNKRAHNMN--------KYIKTNTQDKTVNNSVILRKHSQKQKEDHLRNPPIRSMPASSLQ 646
Cdd:pfam15324  481 QDELARKDYEQKRFDQKNRRTAKAQAAKktsvrrqsKDIKANAQSKTPNKSVIPRKHFQKQAEEHFRKPPVRSMPASSLQ 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  647 KerKEGFLKATTVVQDKDYMLQIYGKPVYQGHRSTLKKGPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFSATK 726
Cdd:pfam15324  561 K--KEGPLKSTTSLQDEDYLLQVYGKAVYQGHRSTLKKGPYLRFNSPSPKSKPQRPKVIESVKGTKVKSARTQTDLHATK 638

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  727 PTKVDSKLQHSITTLSPgDQQYLFSPSREMPTFSGTLEGHLIPMAVLLGQTQSNSDSMPPAGVIVNKPHPVTVTTSIPPS 806
Cdd:pfam15324  639 PVKTDSKMQHSVTAPHQ-EQQYLFSPSREMPSQSGTLEGHLIPMAIPLGQTQSDSDSPPPAGVIVSKPHPVTVTTSIPPS 717

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  807 SRKIEPGVKKPNIAVVEMKSEKRDPPQLSVQVLPNVDIDSISDGSAEVGLSP--SSPKEASSPPLRTWIQAPEFTKADEE 884
Cdd:pfam15324  718 SRKPEPGVKKPNIALLEMKSEKKDPPQLTVQVLPSVDIDSVSCSSRDSSPSPvlPSPSEASPPLIQTWIQTPELMKEDEE 797

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  885 EMKFPGMNFDEVIDIVQEEEKCDEISEYSEPILEFNRSVKAVSTKYNGPPFPPVASTSQPTTDILDKVIHRKETLENSLI 964
Cdd:pfam15324  798 EVKFPGTNFDEVIDVIQDEEKEDEIPEFSEPPLEFNRSVKPPSTKYNGPPFPPVVSQPQPTTDILDKVIEQRETLENRLV 877

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  965 QWVEQEIMSRMISGLLPIQQQATANVSVSVSEASEPLTSDIVEGTSSGALQLFVDAGVPVNSDMIRHIVNEALAETIAVM 1044
Cdd:pfam15324  878 DWVEQEIMARIISGMFPQQAQADPDASVSESEPSEPSTSDIVEAAGGGGLQLFVDAGVPVDSEMIRHFVNEALAETIAIM 957

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432 1045 LGDREAKKPDPVVTGVSGDVSTSETHLParvcTPLATPQPTPPRSPSSPPKEHVLVKTPDSSPSVSDHDVaFPMKEILAE 1124
Cdd:pfam15324  958 LGDREAQREPPVAASVPGDLPTKETLLP----TPVPTPQPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDF-FPVKEIPPE 1032

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432 1125 EG-DDVPAITLVNTPAVTPVTTPPPAAALTPTLSETSIDKLKMSSPELPKPWSDGDLPLEEENPNSLQEELHPRAIVMSV 1203
Cdd:pfam15324 1033 KGaDTGPAVSLVITPTVTPIATPPPAATPTPPLSENSIDKLKSPSPELPKPWEDSDLPLEEENPNSEQEELHPRAVVMSV 1112

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432 1204 AKDEEPESEDFPAqlAPPKPVALMPLPAGIKAPSPIQMPSSDSSTVESTLSVTATESETLDRPISEGEILFNCGLKVAPK 1283
Cdd:pfam15324 1113 ARDEEPESVVLPA--SPPEPKPLAPPPLGAAPPSPPQSPSSSSSTLESSSSLTVTETETADRPISEGEILFSYGQMLAVR 1190

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432 1284 ILGDEGLYLANLNDSLSSTLQDALEMEDDPPSEGQVIRMPHKKVHADAVLSLLAKQNPKSLVSQQAIYHSEDLENSVGEL 1363
Cdd:pfam15324 1191 ALEEGGLFLPNLNDSLSSSLHDAQEMDYDPPSEGQVIRRPHKKAHHDPILSLLAKMNQGPLSSQQAVYHSEDLENSVGEL 1270

                         1290
                   ....*....|....*..
gi 1387196432 1364 SEGQR--LTaAAAENLF 1378
Cdd:pfam15324 1271 SEGQRprLT-AAAENVL 1286
 
Name Accession Description Interval E-value
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 134-1378 0e+00

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 1830.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  134 DIFISQYTVGQKDALRAVLKQKTQSMPVFKEVKVQLLEDAGTEKDPVTQENRISPSGIDSATTVAAATAAAIAAAAPLIK 213
Cdd:pfam15324    1 DIFISQYSAGQKDAVRAVLKQRAQSAPVFKEVKVQLLDDACSEKDAVGPEVQPSPSGIDSATTVAAATAAAIATTAPLIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  214 VQSELEAKVNSVTELLNKLQETDKQLQRVTEQQTTMQNKQETLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQAHFISA 293
Cdd:pfam15324   81 VQSDLEAKVNSVSELLKKLQETDKQLQRVTEQQTSIQAKQEKSCCHDHEKQMNAFMEQRLRHLEKIQQQQIDIQTHLIGS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  294 ALKTSSFQPVTVPPSRAVEKYSV-KPDRLNFGSSNLSSHNVFTSKQAPSREVEDTSFDKQRSPLETPAPRRFAPVPVSKD 372
Cdd:pfam15324  161 ALKAVSLQPSSVTSSRAVEKSGNsSEDESPAVGSASTSHHTFAPKQAPLAEVRDTQFDRQKSPLETPAPRRFAPVPVSRD 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  373 DKISKKENPIEEKENMELSCHAGSVGFLEQILNNHDSLTRISESSDKTSLARSKMGWNPERRNSLDTIATQRFPSCEELG 452
Cdd:pfam15324  241 AKISKREPPKEEKENMETSSSKGNGRLLEQILNNQDSPTRKSESSVVTSLAMATVGWQPERSRESQPLEPQSFPSSEEPE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  453 TAKVTVQKSDDI-HELDQKRKETNSILQLKE------------------SQMSGLADLP------------------QNS 495
Cdd:pfam15324  321 TASVTVQKASDVlQDLGQLKKEMRSLLQTADafpvpnakstrssqssrsLSPLPTPPPPppapismppvtavslaalSSP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  496 VKLQITN-TRSVLKDAEKILRGVQNNKKVLEENLEAIIRAKDGAAMYSFINALSNNREISEKIRIKKTVDDWIKTISAEI 574
Cdd:pfam15324  401 SVLQSTQpPRSMLKDAEKILRQVQNNKKVLEENLEAIIRAKDGAALHSFINALSTNRDMSEEIRIRKTVDEWIKTISKEI 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  575 QDELTRKDYEQKRFDQKNERNKRAHNMN--------KYIKTNTQDKTVNNSVILRKHSQKQKEDHLRNPPIRSMPASSLQ 646
Cdd:pfam15324  481 QDELARKDYEQKRFDQKNRRTAKAQAAKktsvrrqsKDIKANAQSKTPNKSVIPRKHFQKQAEEHFRKPPVRSMPASSLQ 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  647 KerKEGFLKATTVVQDKDYMLQIYGKPVYQGHRSTLKKGPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFSATK 726
Cdd:pfam15324  561 K--KEGPLKSTTSLQDEDYLLQVYGKAVYQGHRSTLKKGPYLRFNSPSPKSKPQRPKVIESVKGTKVKSARTQTDLHATK 638

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  727 PTKVDSKLQHSITTLSPgDQQYLFSPSREMPTFSGTLEGHLIPMAVLLGQTQSNSDSMPPAGVIVNKPHPVTVTTSIPPS 806
Cdd:pfam15324  639 PVKTDSKMQHSVTAPHQ-EQQYLFSPSREMPSQSGTLEGHLIPMAIPLGQTQSDSDSPPPAGVIVSKPHPVTVTTSIPPS 717

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  807 SRKIEPGVKKPNIAVVEMKSEKRDPPQLSVQVLPNVDIDSISDGSAEVGLSP--SSPKEASSPPLRTWIQAPEFTKADEE 884
Cdd:pfam15324  718 SRKPEPGVKKPNIALLEMKSEKKDPPQLTVQVLPSVDIDSVSCSSRDSSPSPvlPSPSEASPPLIQTWIQTPELMKEDEE 797

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  885 EMKFPGMNFDEVIDIVQEEEKCDEISEYSEPILEFNRSVKAVSTKYNGPPFPPVASTSQPTTDILDKVIHRKETLENSLI 964
Cdd:pfam15324  798 EVKFPGTNFDEVIDVIQDEEKEDEIPEFSEPPLEFNRSVKPPSTKYNGPPFPPVVSQPQPTTDILDKVIEQRETLENRLV 877

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  965 QWVEQEIMSRMISGLLPIQQQATANVSVSVSEASEPLTSDIVEGTSSGALQLFVDAGVPVNSDMIRHIVNEALAETIAVM 1044
Cdd:pfam15324  878 DWVEQEIMARIISGMFPQQAQADPDASVSESEPSEPSTSDIVEAAGGGGLQLFVDAGVPVDSEMIRHFVNEALAETIAIM 957

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432 1045 LGDREAKKPDPVVTGVSGDVSTSETHLParvcTPLATPQPTPPRSPSSPPKEHVLVKTPDSSPSVSDHDVaFPMKEILAE 1124
Cdd:pfam15324  958 LGDREAQREPPVAASVPGDLPTKETLLP----TPVPTPQPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDF-FPVKEIPPE 1032

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432 1125 EG-DDVPAITLVNTPAVTPVTTPPPAAALTPTLSETSIDKLKMSSPELPKPWSDGDLPLEEENPNSLQEELHPRAIVMSV 1203
Cdd:pfam15324 1033 KGaDTGPAVSLVITPTVTPIATPPPAATPTPPLSENSIDKLKSPSPELPKPWEDSDLPLEEENPNSEQEELHPRAVVMSV 1112

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432 1204 AKDEEPESEDFPAqlAPPKPVALMPLPAGIKAPSPIQMPSSDSSTVESTLSVTATESETLDRPISEGEILFNCGLKVAPK 1283
Cdd:pfam15324 1113 ARDEEPESVVLPA--SPPEPKPLAPPPLGAAPPSPPQSPSSSSSTLESSSSLTVTETETADRPISEGEILFSYGQMLAVR 1190

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432 1284 ILGDEGLYLANLNDSLSSTLQDALEMEDDPPSEGQVIRMPHKKVHADAVLSLLAKQNPKSLVSQQAIYHSEDLENSVGEL 1363
Cdd:pfam15324 1191 ALEEGGLFLPNLNDSLSSSLHDAQEMDYDPPSEGQVIRRPHKKAHHDPILSLLAKMNQGPLSSQQAVYHSEDLENSVGEL 1270

                         1290
                   ....*....|....*..
gi 1387196432 1364 SEGQR--LTaAAAENLF 1378
Cdd:pfam15324 1271 SEGQRprLT-AAAENVL 1286
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 543-914 6.92e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.19  E-value: 6.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  543 FINALsnnreISEKIRIKKTVDDwiktisaEIQDELTRKDYeqKRFDQKNErnKRAHNMNKYIKTNTQDKTVNNSVILRK 622
Cdd:PTZ00108  1017 FIKHV-----INGELVITNAKKK-------DLVKELKKLGY--VRFKDIIK--KKSEKITAEEEEGAEEDDEADDEDDEE 1080

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  623 HSQKQKE-DHLRnppirSMPASSLQKERKEGF-------------LKATTVVQ------DK--DYMLQIYGKPVY---QG 677
Cdd:PTZ00108  1081 ELGAAVSyDYLL-----SMPIWSLTKEKVEKLnaelekkekelekLKNTTPKDmwledlDKfeEALEEQEEVEEKeiaKE 1155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  678 HRSTLKKGpylrfNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFSATK-----PTKVDSKLQHSITTLSPGDQQYLFSP 752
Cdd:PTZ00108  1156 QRLKSKTK-----GKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKrvdsdEKRKLDDKPDNKKSNSSGSDQEDDEE 1230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  753 SREMPTFSGTLEGHLIP---MAVLLGQTQSNSDSMPPAGVIVNKPHPVTVTTSIPPSSRKIEPGVKKPNIAVVEMKSEKR 829
Cdd:PTZ00108  1231 QKTKPKKSSVKRLKSKKnnsSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKV 1310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  830 DPPQLSVQVLPNVDIDSiSDGSAEVGLSPSSPKEASSPPLRTWIQAPEFTKADEEEMkfpgmnfDEVIDIVQEEEKCDEI 909
Cdd:PTZ00108  1311 KKRLEGSLAALKKKKKS-EKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSE-------DDDDSEVDDSEDEDDE 1382


                   ....*
gi 1387196432  910 SEYSE 914
Cdd:PTZ00108  1383 DDEDD 1387
 
Name Accession Description Interval E-value
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 134-1378 0e+00

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 1830.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  134 DIFISQYTVGQKDALRAVLKQKTQSMPVFKEVKVQLLEDAGTEKDPVTQENRISPSGIDSATTVAAATAAAIAAAAPLIK 213
Cdd:pfam15324    1 DIFISQYSAGQKDAVRAVLKQRAQSAPVFKEVKVQLLDDACSEKDAVGPEVQPSPSGIDSATTVAAATAAAIATTAPLIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  214 VQSELEAKVNSVTELLNKLQETDKQLQRVTEQQTTMQNKQETLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQAHFISA 293
Cdd:pfam15324   81 VQSDLEAKVNSVSELLKKLQETDKQLQRVTEQQTSIQAKQEKSCCHDHEKQMNAFMEQRLRHLEKIQQQQIDIQTHLIGS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  294 ALKTSSFQPVTVPPSRAVEKYSV-KPDRLNFGSSNLSSHNVFTSKQAPSREVEDTSFDKQRSPLETPAPRRFAPVPVSKD 372
Cdd:pfam15324  161 ALKAVSLQPSSVTSSRAVEKSGNsSEDESPAVGSASTSHHTFAPKQAPLAEVRDTQFDRQKSPLETPAPRRFAPVPVSRD 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  373 DKISKKENPIEEKENMELSCHAGSVGFLEQILNNHDSLTRISESSDKTSLARSKMGWNPERRNSLDTIATQRFPSCEELG 452
Cdd:pfam15324  241 AKISKREPPKEEKENMETSSSKGNGRLLEQILNNQDSPTRKSESSVVTSLAMATVGWQPERSRESQPLEPQSFPSSEEPE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  453 TAKVTVQKSDDI-HELDQKRKETNSILQLKE------------------SQMSGLADLP------------------QNS 495
Cdd:pfam15324  321 TASVTVQKASDVlQDLGQLKKEMRSLLQTADafpvpnakstrssqssrsLSPLPTPPPPppapismppvtavslaalSSP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  496 VKLQITN-TRSVLKDAEKILRGVQNNKKVLEENLEAIIRAKDGAAMYSFINALSNNREISEKIRIKKTVDDWIKTISAEI 574
Cdd:pfam15324  401 SVLQSTQpPRSMLKDAEKILRQVQNNKKVLEENLEAIIRAKDGAALHSFINALSTNRDMSEEIRIRKTVDEWIKTISKEI 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  575 QDELTRKDYEQKRFDQKNERNKRAHNMN--------KYIKTNTQDKTVNNSVILRKHSQKQKEDHLRNPPIRSMPASSLQ 646
Cdd:pfam15324  481 QDELARKDYEQKRFDQKNRRTAKAQAAKktsvrrqsKDIKANAQSKTPNKSVIPRKHFQKQAEEHFRKPPVRSMPASSLQ 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  647 KerKEGFLKATTVVQDKDYMLQIYGKPVYQGHRSTLKKGPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFSATK 726
Cdd:pfam15324  561 K--KEGPLKSTTSLQDEDYLLQVYGKAVYQGHRSTLKKGPYLRFNSPSPKSKPQRPKVIESVKGTKVKSARTQTDLHATK 638

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  727 PTKVDSKLQHSITTLSPgDQQYLFSPSREMPTFSGTLEGHLIPMAVLLGQTQSNSDSMPPAGVIVNKPHPVTVTTSIPPS 806
Cdd:pfam15324  639 PVKTDSKMQHSVTAPHQ-EQQYLFSPSREMPSQSGTLEGHLIPMAIPLGQTQSDSDSPPPAGVIVSKPHPVTVTTSIPPS 717

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  807 SRKIEPGVKKPNIAVVEMKSEKRDPPQLSVQVLPNVDIDSISDGSAEVGLSP--SSPKEASSPPLRTWIQAPEFTKADEE 884
Cdd:pfam15324  718 SRKPEPGVKKPNIALLEMKSEKKDPPQLTVQVLPSVDIDSVSCSSRDSSPSPvlPSPSEASPPLIQTWIQTPELMKEDEE 797

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  885 EMKFPGMNFDEVIDIVQEEEKCDEISEYSEPILEFNRSVKAVSTKYNGPPFPPVASTSQPTTDILDKVIHRKETLENSLI 964
Cdd:pfam15324  798 EVKFPGTNFDEVIDVIQDEEKEDEIPEFSEPPLEFNRSVKPPSTKYNGPPFPPVVSQPQPTTDILDKVIEQRETLENRLV 877

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  965 QWVEQEIMSRMISGLLPIQQQATANVSVSVSEASEPLTSDIVEGTSSGALQLFVDAGVPVNSDMIRHIVNEALAETIAVM 1044
Cdd:pfam15324  878 DWVEQEIMARIISGMFPQQAQADPDASVSESEPSEPSTSDIVEAAGGGGLQLFVDAGVPVDSEMIRHFVNEALAETIAIM 957

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432 1045 LGDREAKKPDPVVTGVSGDVSTSETHLParvcTPLATPQPTPPRSPSSPPKEHVLVKTPDSSPSVSDHDVaFPMKEILAE 1124
Cdd:pfam15324  958 LGDREAQREPPVAASVPGDLPTKETLLP----TPVPTPQPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDF-FPVKEIPPE 1032

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432 1125 EG-DDVPAITLVNTPAVTPVTTPPPAAALTPTLSETSIDKLKMSSPELPKPWSDGDLPLEEENPNSLQEELHPRAIVMSV 1203
Cdd:pfam15324 1033 KGaDTGPAVSLVITPTVTPIATPPPAATPTPPLSENSIDKLKSPSPELPKPWEDSDLPLEEENPNSEQEELHPRAVVMSV 1112

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432 1204 AKDEEPESEDFPAqlAPPKPVALMPLPAGIKAPSPIQMPSSDSSTVESTLSVTATESETLDRPISEGEILFNCGLKVAPK 1283
Cdd:pfam15324 1113 ARDEEPESVVLPA--SPPEPKPLAPPPLGAAPPSPPQSPSSSSSTLESSSSLTVTETETADRPISEGEILFSYGQMLAVR 1190

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432 1284 ILGDEGLYLANLNDSLSSTLQDALEMEDDPPSEGQVIRMPHKKVHADAVLSLLAKQNPKSLVSQQAIYHSEDLENSVGEL 1363
Cdd:pfam15324 1191 ALEEGGLFLPNLNDSLSSSLHDAQEMDYDPPSEGQVIRRPHKKAHHDPILSLLAKMNQGPLSSQQAVYHSEDLENSVGEL 1270

                         1290
                   ....*....|....*..
gi 1387196432 1364 SEGQR--LTaAAAENLF 1378
Cdd:pfam15324 1271 SEGQRprLT-AAAENVL 1286
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 543-914 6.92e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.19  E-value: 6.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  543 FINALsnnreISEKIRIKKTVDDwiktisaEIQDELTRKDYeqKRFDQKNErnKRAHNMNKYIKTNTQDKTVNNSVILRK 622
Cdd:PTZ00108  1017 FIKHV-----INGELVITNAKKK-------DLVKELKKLGY--VRFKDIIK--KKSEKITAEEEEGAEEDDEADDEDDEE 1080

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  623 HSQKQKE-DHLRnppirSMPASSLQKERKEGF-------------LKATTVVQ------DK--DYMLQIYGKPVY---QG 677
Cdd:PTZ00108  1081 ELGAAVSyDYLL-----SMPIWSLTKEKVEKLnaelekkekelekLKNTTPKDmwledlDKfeEALEEQEEVEEKeiaKE 1155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  678 HRSTLKKGpylrfNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFSATK-----PTKVDSKLQHSITTLSPGDQQYLFSP 752
Cdd:PTZ00108  1156 QRLKSKTK-----GKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKrvdsdEKRKLDDKPDNKKSNSSGSDQEDDEE 1230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  753 SREMPTFSGTLEGHLIP---MAVLLGQTQSNSDSMPPAGVIVNKPHPVTVTTSIPPSSRKIEPGVKKPNIAVVEMKSEKR 829
Cdd:PTZ00108  1231 QKTKPKKSSVKRLKSKKnnsSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKV 1310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196432  830 DPPQLSVQVLPNVDIDSiSDGSAEVGLSPSSPKEASSPPLRTWIQAPEFTKADEEEMkfpgmnfDEVIDIVQEEEKCDEI 909
Cdd:PTZ00108  1311 KKRLEGSLAALKKKKKS-EKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSE-------DDDDSEVDDSEDEDDE 1382


                   ....*
gi 1387196432  910 SEYSE 914
Cdd:PTZ00108  1383 DDEDD 1387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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