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Conserved domains on  [gi|528948279|ref|XP_005206115|]
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POC1 centriolar protein homolog B isoform X5 [Bos taurus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-300 6.39e-104

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 312.23  E-value: 6.39e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279   6 EDPVLERYFKGHKAAITSVDFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIR 85
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  86 LWIPDKRGKSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSED 165
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 166 KTIKIWDTTNKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLIT 245
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 528948279 246 ASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWRTN 300
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-300 6.39e-104

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 312.23  E-value: 6.39e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279   6 EDPVLERYFKGHKAAITSVDFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIR 85
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  86 LWIPDKRGKSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSED 165
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 166 KTIKIWDTTNKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLIT 245
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 528948279 246 ASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWRTN 300
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-298 2.23e-96

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 288.85  E-value: 2.23e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  10 LERYFKGHKAAITSVDFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIRLWIP 89
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  90 DKRGKSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIK 169
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 170 IWDTTNKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLITASSD 249
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 528948279 250 GTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWR 298
Cdd:cd00200  241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-172 2.92e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 2.92e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 528948279   135 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 172
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 32-258 3.11e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.03  E-value: 3.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  32 QLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLG-NLLASASRDRTIRLWIPDKrGKSSEFKAHTAPVRSVDF 110
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQ-GVSIGTIKTKANICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 111 SAD-GQFLASASEDKSIKVWNMYRQRF-LYSLYRHTHWVRCAKFSpDGRLIVSCSEDKTIKIWDTT------NKQCVNNF 182
Cdd:PLN00181 626 PSEsGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSF 704

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 183 SDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVH-------------SGGVNCVSFHPSGNYLITASSD 249
Cdd:PLN00181 705 MGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKtidpvsglevddaSQFISSVCWRGQSSTLVAANST 784


                 ....*....
gi 528948279 250 GTLKILDLL 258
Cdd:PLN00181 785 GNIKILEMV 793
WD40 pfam00400
WD domain, G-beta repeat;
135-172 7.15e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 7.15e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528948279  135 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 172
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-300 6.39e-104

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 312.23  E-value: 6.39e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279   6 EDPVLERYFKGHKAAITSVDFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIR 85
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  86 LWIPDKRGKSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSED 165
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 166 KTIKIWDTTNKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLIT 245
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 528948279 246 ASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWRTN 300
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
6-300 6.13e-100

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 302.22  E-value: 6.13e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279   6 EDPVLERYFKGHKAAITSVDFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIR 85
Cdd:COG2319   66 AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  86 LWIPDKRGKSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSED 165
Cdd:COG2319  146 LWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAD 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 166 KTIKIWDTTNKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLIT 245
Cdd:COG2319  226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 528948279 246 ASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWRTN 300
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-298 2.23e-96

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 288.85  E-value: 2.23e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  10 LERYFKGHKAAITSVDFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIRLWIP 89
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  90 DKRGKSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIK 169
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 170 IWDTTNKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLITASSD 249
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 528948279 250 GTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWR 298
Cdd:cd00200  241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
16-300 3.61e-88

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 272.17  E-value: 3.61e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  16 GHKAAITSVDFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIRLWIPDKRGKS 95
Cdd:COG2319   34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  96 SEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN 175
Cdd:COG2319  114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 176 KQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLITASSDGTLKIL 255
Cdd:COG2319  194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 528948279 256 DLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWRTN 300
Cdd:COG2319  274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-299 6.57e-81

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 249.56  E-value: 6.57e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  58 GHKDVITSVQFSPLGNLLASASRDRTIRLWIPDKRGKSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFL 137
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 138 YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRV 217
Cdd:cd00200   87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 218 NKLLQHYQVHSGGVNCVSFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLW 297
Cdd:cd00200  167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246


                 ..
gi 528948279 298 RT 299
Cdd:cd00200  247 DL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-254 2.78e-78

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 242.63  E-value: 2.78e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279   6 EDPVLERYFKGHKAAITSVDFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIR 85
Cdd:cd00200   39 ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  86 LWIPDKRGKSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSED 165
Cdd:cd00200  119 VWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 166 KTIKIWDTTNKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLIT 245
Cdd:cd00200  199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278


                 ....*....
gi 528948279 246 ASSDGTLKI 254
Cdd:cd00200  279 GSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
25-300 2.63e-74

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 236.35  E-value: 2.63e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  25 DFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIRLWIPDKRGKSSEFKAHTAP 104
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 105 VRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSD 184
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 185 FVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLITASSDGTLKILDLLEGRLIY 264
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 528948279 265 TLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWRTN 300
Cdd:COG2319  241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-304 9.77e-65

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 207.96  E-value: 9.77e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  95 SSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 175 NKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLITASSDGTLKI 254
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 528948279 255 LDLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWRTNFDEL 304
Cdd:cd00200  162 WDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211
WD40 COG2319
WD40 repeat [General function prediction only];
14-175 5.23e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 186.27  E-value: 5.23e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  14 FKGHKAAITSVDFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIRLWIPDKRG 93
Cdd:COG2319  242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  94 KSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
Cdd:COG2319  322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401


                 ..
gi 528948279 174 TN 175
Cdd:COG2319  402 AT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 220-304 8.55e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 8.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 220 LLQHYQVHSGGVNCVSFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWRT 299
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80


                 ....*
gi 528948279 300 NFDEL 304
Cdd:cd00200   81 ETGEC 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-172 2.92e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 2.92e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 528948279   135 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 172
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 32-258 3.11e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.03  E-value: 3.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  32 QLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLG-NLLASASRDRTIRLWIPDKrGKSSEFKAHTAPVRSVDF 110
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQ-GVSIGTIKTKANICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 111 SAD-GQFLASASEDKSIKVWNMYRQRF-LYSLYRHTHWVRCAKFSpDGRLIVSCSEDKTIKIWDTT------NKQCVNNF 182
Cdd:PLN00181 626 PSEsGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSF 704

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 183 SDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVH-------------SGGVNCVSFHPSGNYLITASSD 249
Cdd:PLN00181 705 MGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKtidpvsglevddaSQFISSVCWRGQSSTLVAANST 784


                 ....*....
gi 528948279 250 GTLKILDLL 258
Cdd:PLN00181 785 GNIKILEMV 793
WD40 pfam00400
WD domain, G-beta repeat;
135-172 7.15e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 7.15e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528948279  135 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 172
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 57-264 1.06e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 59.91  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  57 VGHKDVITSVQFSPLGNL-LASASRDRTIRLW-IPDKRGKSS------EFKAHTAPVRSVDF--SADGqFLASASEDKSI 126
Cdd:PTZ00421  72 LGQEGPIIDVAFNPFDPQkLFTASEDGTIMGWgIPEEGLTQNisdpivHLQGHTKKVGIVSFhpSAMN-VLASAGADMVV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 127 KVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDFVGF----------ANFVAfnp 196
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksqrclwakrKDLII--- 227

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528948279 197 ngTCIASAGSDHTVKIWDIRvnKLLQHYQVHSGGVNCVSFHP----SGNYLITAS-SDGTLKILDLLEGRLIY 264
Cdd:PTZ00421 228 --TLGCSKSQQRQIMLWDTR--KMASPYSTVDLDQSSALFIPffdeDTNLLYIGSkGEGNIRCFELMNERLTF 296
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-130 7.32e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 7.32e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 528948279    96 SEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWN 130
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
97-130 1.13e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 1.13e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 528948279   97 EFKAHTAPVRSVDFSADGQFLASASEDKSIKVWN 130
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 219-256 2.07e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 2.07e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 528948279   219 KLLQHYQVHSGGVNCVSFHPSGNYLITASSDGTLKILD 256
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 1-173 6.68e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.13  E-value: 6.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279   1 MASSPedPVLeryfKGHKAAITSVDFSP-NGKQLATGSWDTFLMLWSLRPQA-------RAFRYVGHKDVITSVQFSPLG 72
Cdd:PTZ00421  64 LASNP--PIL----LGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGltqnisdPIVHLQGHTKKVGIVSFHPSA 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  73 -NLLASASRDRTIRLWipD-KRGKSSE-FKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRH--THWV 147
Cdd:PTZ00421 138 mNVLASAGADMVVNVW--DvERGKAVEvIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHasAKSQ 215

                        170       180       190
                 ....*....|....*....|....*....|
gi 528948279 148 RC--AKfSPDGRLIVSCS--EDKTIKIWDT 173
Cdd:PTZ00421 216 RClwAK-RKDLIITLGCSksQQRQIMLWDT 244
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-87 7.38e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 7.38e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 528948279    54 FRYVGHKDVITSVQFSPLGNLLASASRDRTIRLW 87
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
218-256 1.64e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.64e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528948279  218 NKLLQHYQVHSGGVNCVSFHPSGNYLITASSDGTLKILD 256
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 10-46 1.72e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.72e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 528948279    10 LERYFKGHKAAITSVDFSPNGKQLATGSWDTFLMLWS 46
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
4-48 2.18e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 2.18e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 528948279   4 SPEDPVLERYFKGHKAAITSVDFSPNGKQLATGSWDTFLMLWSLR 48
Cdd:COG2319  358 DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 pfam00400
WD domain, G-beta repeat;
56-87 3.26e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 3.26e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 528948279   56 YVGHKDVITSVQFSPLGNLLASASRDRTIRLW 87
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
14-46 3.29e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 3.29e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 528948279   14 FKGHKAAITSVDFSPNGKQLATGSWDTFLMLWS 46
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 151-299 2.44e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 2.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 151 KFSP-DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDFV----GFAN---FVAFNPNGT-CIASAGSDHTVKIWDIRVNKLL 221
Cdd:PTZ00421  82 AFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIvhlqGHTKkvgIVSFHPSAMnVLASAGADMVVNVWDVERGKAV 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 222 QHYQVHSGGVNCVSFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGP-------------VFTVSFSKGGElftsg 288
Cdd:PTZ00421 162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksqrclwakrkdlIITLGCSKSQQ----- 236

                        170
                 ....*....|.
gi 528948279 289 gadAQVLLWRT 299
Cdd:PTZ00421 237 ---RQIMLWDT 244
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-214 3.92e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.92e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528948279   175 NKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWD 214
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 260-297 3.95e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.95e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 528948279   260 GRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLW 297
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 14-101 1.11e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  14 FKGHKAAITSVDFSP-NGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDvITSVQFSPLGNLLASASRDRTIRLWIPDKR 92
Cdd:PTZ00420 121 LKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIWDIENEKRAFQINMPKK-LSSLKWNIKGNLLSGTCVGKHMHIIDPRKQ 199


                 ....*....
gi 528948279  93 GKSSEFKAH 101
Cdd:PTZ00420 200 EIASSFHIH 208
WD40 pfam00400
WD domain, G-beta repeat;
260-297 1.21e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528948279  260 GRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLW 297
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 192-236 7.79e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.11  E-value: 7.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 528948279  192 VAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSF 236
Cdd:pfam12894  44 LAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGW 88
PTZ00420 PTZ00420
coronin; Provisional
 58-216 8.96e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 8.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  58 GHKDVITSVQFSP-LGNLLASASRDRTIRLW-IPDKRGKSSEFK-------AHTAPVRSVDFSADGQF-LASASEDKSIK 127
Cdd:PTZ00420  72 GHTSSILDLQFNPcFSEILASGSEDLTIRVWeIPHNDESVKEIKdpqcilkGHKKKISIIDWNPMNYYiMCSSGFDSFVN 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 128 VWNMYRQRFLYSLYRHTHwVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDFVGFAN-----FVAFNPNGTCIA 202
Cdd:PTZ00420 152 IWDIENEKRAFQINMPKK-LSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNtkniwIDGLGGDDNYIL 230

                        170
                 ....*....|....*...
gi 528948279 203 SAGSDHT----VKIWDIR 216
Cdd:PTZ00420 231 STGFSKNnmreMKLWDLK 248
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 17-83 9.00e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 43.91  E-value: 9.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279   17 HKAAITSVDFSPNGKQLATGSWDTFLMLWSL---RPQARAFR----------YV----------GHKDVITSVQFSPLGN 73
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgRSSEKRSRntqtefprkdHViaetpfhilcGHDDIITCLYVSVELD 202

                          90
                  ....*....|
gi 528948279   74 LLASASRDRT 83
Cdd:pfam20426 203 IVISGSKDGT 212
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
39-219 2.00e-04

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 43.09  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  39 DTFLMLWSLRpqARAFRYVGHKDVITSVQFsPLGNLLASASRDRTIRLWIPDK----RGKSSEFKAHTAPVRSVDFSADG 114
Cdd:COG5170  108 DKTIKLWKIY--EKNLKVVAENNLSDSFHS-PMGGPLTSTKELLLPRLSEHDEiiaaKPCRVYANAHPYHINSISFNSDK 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 115 QFLASAsEDKSIKVWNMYRQRFLYSLY--------RHTHWVRCAKFSPDGRLIVSCSEDK-TIKIWDT-TNKQC------ 178
Cdd:COG5170  185 ETLLSA-DDLRINLWNLEIIDGSFNIVdikphnmeELTEVITSAEFHPEMCNVFMYSSSKgEIKLNDLrQSALCdnskkl 263

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 528948279 179 ---------VNNFSDFVGFANFVAFNPNGTCIASAgSDHTVKIWDIRVNK 219
Cdd:COG5170  264 feltidgvdVDFFEEIVSSISDFKFSDNGRYILSR-DYLTVKIWDVNMAK 312
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 211-279 2.11e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.95  E-value: 2.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528948279  211 KIWDIRVNKllqhyqvHSGGVNCVSFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFS 279
Cdd:pfam12894  28 RVWTLSPDK-------EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
PTZ00420 PTZ00420
coronin; Provisional
 125-219 2.47e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.01  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 125 SIKVWNMYRQRFLYSLYRHTHWVRCAKFSP-DGRLIVSCSEDKTIKIWDTT-NKQCVNNFSDFVGF-------ANFVAFN 195
Cdd:PTZ00420  55 AIRLENQMRKPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPhNDESVKEIKDPQCIlkghkkkISIIDWN 134

                         90       100
                 ....*....|....*....|....*
gi 528948279 196 P-NGTCIASAGSDHTVKIWDIRVNK 219
Cdd:PTZ00420 135 PmNYYIMCSSGFDSFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
176-214 2.53e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528948279  176 KQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWD 214
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
41-262 2.74e-04

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 42.71  E-value: 2.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  41 FLMLWSlrpQARAFR----YVGHKDVITSVQFSPLGNLLASASRDRTIRLWIPDK-RGKSS----EFKAHTA-------- 103
Cdd:COG5170    6 EILKFK---QCFGDKldlnSSTEADKITAVEFDETGLYLATGDKGGRVVLFEREKsYGCEYkfftEFQSHELefdylksl 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 104 ----PVRSVDFSADGQ---FLASASeDKSIKVWNMY-RQRFLYSLYRHTHWVRCAK----FSPDGRLIVSCSE-DKTIKI 170
Cdd:COG5170   83 eieeKINAIEWFDDTGrnhFLLSTN-DKTIKLWKIYeKNLKVVAENNLSDSFHSPMggplTSTKELLLPRLSEhDEIIAA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 171 WDTTNKQCVNNFsdfvgFANFVAFNPNGTCIASAG-----------SDHTVKIWDIRVNKLLQHYQVhsggVNCVSFHP- 238
Cdd:COG5170  162 KPCRVYANAHPY-----HINSISFNSDKETLLSADdlrinlwnleiIDGSFNIVDIKPHNMEELTEV----ITSAEFHPe 232

                        250       260
                 ....*....|....*....|....
gi 528948279 239 SGNYLITASSDGTLKILDLLEGRL 262
Cdd:COG5170  233 MCNVFMYSSSKGEIKLNDLRQSAL 256
COG5354 COG5354
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];
64-285 3.40e-04

Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];


Pssm-ID: 227657 [Multi-domain]  Cd Length: 561  Bit Score: 42.55  E-value: 3.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  64 TSVQFSPLGNLLASASRdRTIRLWIPDKRGKSSEFKAhtAPVRSVDFSADGQFLASAS---------------EDKSIKV 128
Cdd:COG5354   36 AYVSESPLGTYLFSEHA-AGVECWGGPSKAKLVRFRH--PDVKYLDFSPNEKYLVTWSrepiiepeieispftSKNNVFV 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 129 WNMYRQRFLYSL----YRHTHWvRCAKFSPDGRLIVSCSEDkTIKIWDTTNKQCVNNF--SDFVGFANFvAFNP--NGTC 200
Cdd:COG5354  113 WDIASGMIVFSFngisQPYLGW-PVLKFSIDDKYVARVVGS-SLYIHEITDNIEEHPFknLRPVGILDF-SISPegNHDE 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 201 IA-----SAGSDHTVKIWDIRVNKLL-QHYQVHSGGVNcVSFHPSGNYL----ITASSDG-------TLKILDlLEGRLI 263
Cdd:COG5354  190 LAywtpeKLNKPAMVRILSIPKNSVLvTKNLFKVSGVQ-LKWQVLGKYLlvlvMTHTKSNksyfgesNLYLLR-ITERSI 267

                        250       260
                 ....*....|....*....|..
gi 528948279 264 YTLQGHTGPVFTVSFSKGGELF 285
Cdd:COG5354  268 PVEKDLKDPVHDFTWEPLSSRF 289
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 19-157 1.52e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.79  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279   19 AAITSVDFSPNGKQLA-----TGSWDtflmLWsLRPQ-----ARAFRYVGHKDViTSVQFSPLGNLLASASRDRtiRLWI 88
Cdd:COG4946   343 VRERLPAWSPDGKSIAyfsdaSGEYE----LY-IAPAdgsgePKQLTLGDLGRV-FNPVWSPDGKKIAFTDNRG--RLWV 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279   89 PDKRGKSSEfKAHTAP----VRSVDFSADGQFLA-SASEDksikvwNMYRQRFLYS--------LYRHTHWVRCAKFSPD 155
Cdd:COG4946   415 VDLASGKVR-KVDTDGygdgISDLAWSPDSKWLAySKPGP------NQLSQIFLYDvetgktvqLTDGRYDDGSPAFSPD 487


                  ..
gi 528948279  156 GR 157
Cdd:COG4946   488 GK 489
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 59-101 2.36e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.67  E-value: 2.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 528948279   59 HKDVITSVQFSPLGNLLASASRDRTIRLW------IPDKRGKSSEFKAH 101
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVWevlrgrSSEKRSRNTQTEFP 171
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 152-245 4.34e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 38.33  E-value: 4.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279 152 FSPDGRLIVSCSEDKTIKIWDTTNKQcVNNFSDFVGFANFVAFNPNGTCIAsAGSDHTVKIWDI---RVNKLLQHYQVHS 228
Cdd:COG3386   15 WDPDGRLYWVDIPGGRIHRYDPDGGA-VEVFAEPSGRPNGLAFDPDGRLLV-ADHGRGLVRFDPadgEVTVLADEYGKPL 92

                         90
                 ....*....|....*..
gi 528948279 229 GGVNCVSFHPSGNYLIT 245
Cdd:COG3386   93 NRPNDGVVDPDGRLYFT 109
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 17-122 4.49e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 37.34  E-value: 4.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528948279  17 HKAAITSVDFSPNGKQLA-TGSWDTFLMLWSLRPQARAFRYVGHKDVI-TSVQFSPLGNLLASASR-DRTIRLWIPDKRG 93
Cdd:COG0823   29 SPGIDTSPAWSPDGRRIAfTSDRGGGPQIYVVDADGGEPRRLTFGGGYnASPSWSPDGKRLAFVSRsDGRFDIYVLDLDG 108

                         90       100
                 ....*....|....*....|....*....
gi 528948279  94 ksSEFKAHTAPVRSVDFSADGQFLASASE 122
Cdd:COG0823  109 --GAPRRLTDGPGSPSWSPDGRRIVFSSD 135
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 117-183 5.52e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.72  E-value: 5.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528948279  117 LASASEDKSIKVWNMYRQR-FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS 183
Cdd:pfam12894  10 IALATEDGELLLHRLNWQRvWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFS 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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