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Conserved domains on  [gi|528508691|ref|XP_005173748|]
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ubiquitin-conjugating enzyme E2 Q1 isoform X1 [Danio rerio]

Protein Classification

ubiquitin-conjugating enzyme family protein( domain architecture ID 439)

ubiquitin-conjugating enzyme family protein similar to ubiquitin-conjugating enzyme E2 that catalyzes the covalent attachment of ubiquitin to other proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBCc_UBE2Q cd23802
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, ...
 209-364 8.72e-80

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and related proteins; The E2Q subfamily includes mammalian ubiquitin-conjugating enzymes E2 Q1 (UBE2Q1/NICE5/UBE2Q), Q2 (UBE2Q2), and similar proteins. They are ubiquitin-conjugating (EC 2.3.2.23) enzymes that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2Q1 may be involved in hormonal homeostasis in females. It is involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation. In vitro, UBE2Q2 catalyzes 'Lys-48'-linked polyubiquitination. This subfamily also includes ubiquitin-conjugating enzyme E2Q-like protein 1 (UBE2QL1), which is a probable E2 ubiquitin-protein ligase that may facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.


:

Pssm-ID: 467422  Cd Length: 157  Bit Score: 241.38  E-value: 8.72e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691 209 DRLMKELREIYRSQSYKNGiYSVELLNDSLYDWHIKLRTVDPDSALHSDLQVLKEKEGMDYILLNFSYKDNFPFDPPFVR 288
Cdd:cd23802    1 KRLMKELKDLMKSQSKKLG-FSVDPVDDNLYHWEVKLFGFDPDSPLAKDLKKLKKKHGYDYIELELRFPDLYPFYPPFVR 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528508691 289 VVSPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGKARVQFGA--NKNQYNLARAQQSYKSLVQIH 364
Cdd:cd23802   80 VVRPRLKGGTGHVGGAICMELLTLSGWSPAYSIESVLLQIRALLVKGGARDDFSAraNKSPYSEAEARAAFKRLARIH 157
 
Name Accession Description Interval E-value
UBCc_UBE2Q cd23802
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, ...
 209-364 8.72e-80

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and related proteins; The E2Q subfamily includes mammalian ubiquitin-conjugating enzymes E2 Q1 (UBE2Q1/NICE5/UBE2Q), Q2 (UBE2Q2), and similar proteins. They are ubiquitin-conjugating (EC 2.3.2.23) enzymes that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2Q1 may be involved in hormonal homeostasis in females. It is involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation. In vitro, UBE2Q2 catalyzes 'Lys-48'-linked polyubiquitination. This subfamily also includes ubiquitin-conjugating enzyme E2Q-like protein 1 (UBE2QL1), which is a probable E2 ubiquitin-protein ligase that may facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.


Pssm-ID: 467422  Cd Length: 157  Bit Score: 241.38  E-value: 8.72e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691 209 DRLMKELREIYRSQSYKNGiYSVELLNDSLYDWHIKLRTVDPDSALHSDLQVLKEKEGMDYILLNFSYKDNFPFDPPFVR 288
Cdd:cd23802    1 KRLMKELKDLMKSQSKKLG-FSVDPVDDNLYHWEVKLFGFDPDSPLAKDLKKLKKKHGYDYIELELRFPDLYPFYPPFVR 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528508691 289 VVSPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGKARVQFGA--NKNQYNLARAQQSYKSLVQIH 364
Cdd:cd23802   80 VVRPRLKGGTGHVGGAICMELLTLSGWSPAYSIESVLLQIRALLVKGGARDDFSAraNKSPYSEAEARAAFKRLARIH 157
UBCc smart00212
Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for ...
 210-364 7.13e-19

Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. This pathway functions in regulating many fundamental processes required for cell viability.TSG101 is one of several UBC homologues that lacks this active site cysteine.


Pssm-ID: 214562 [Multi-domain]  Cd Length: 145  Bit Score: 82.34  E-value: 7.13e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691   210 RLMKELREIYRSQsyKNGIYSVELLNDSLYDWHIKLrtVDPDSALHsdlqvlkekEGMDYIL-LNFSykDNFPFDPPFVR 288
Cdd:smart00212   1 RLLKELKELRKDP--PPGFTAYPVDDENLLEWTGTI--VGPPGTPY---------EGGVFKLtIEFP--EDYPFKPPKVK 65

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528508691   289 VVSPVLsGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGKARvqFGANKNQYNLARA-QQSYKSLVQIH 364
Cdd:smart00212  66 FITKIY-HPNVDSSGEICLDILKQEKWSPALTLETVLLSLQSLLSEPNPD--SPLNADAAELYKKnREEFKKKAREW 139
UQ_con pfam00179
Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ...
 210-332 6.28e-09

Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologs. TSG101 is one of several UBC homologs that lacks this active site cysteine.


Pssm-ID: 459701 [Multi-domain]  Cd Length: 139  Bit Score: 54.12  E-value: 6.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691  210 RLMKELREIyrsQSYKNGIYSVELLNDSLYDWHIKLrtVDPDSALHsdlqvlkekEGMDYILlNFSYKDNFPFDPPFVRV 289
Cdd:pfam00179   1 RLQKELKEL---LKDPPPGISAGPVDDNLFEWKVTI--IGPDGTPY---------EGGVFKL-SVEFPEDYPFKPPKVKF 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 528508691  290 VSPVlsggY---VLGGGALCMELLTKQGWSSAYSIESVIMQINATL 332
Cdd:pfam00179  66 TTKI----YhpnVDSSGEVCLDILKDERWSPALTLEQVLLSIQSLL 107
PLN00172 PLN00172
ubiquitin conjugating enzyme; Provisional
 207-355 1.01e-05

ubiquitin conjugating enzyme; Provisional


Pssm-ID: 177768 [Multi-domain]  Cd Length: 147  Bit Score: 45.13  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691 207 ASDRLMKELREIYRSQSYKngiYSVELLNDSLYDWHIKLrtVDPDSALHSDlqvlkekegmDYILLNFSYKDNFPFDPPF 286
Cdd:PLN00172   2 ATKRIQKEHKDLLKDPPSN---CSAGPSDENLFRWTASI--IGPSDSPYAG----------GVFFLSILFPPDYPFKPPK 66

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528508691 287 VRVVSPVLSGGyVLGGGALCMELLTKQgWSSAYSIESVIMQINA---------TLVKGKARVqFGANKNQYNlARAQQ 355
Cdd:PLN00172  67 VQFTTKIYHPN-INSNGSICLDILRDQ-WSPALTVSKVLLSISSlltdpnpddPLVPEIARV-FKENRSRYE-ATARE 140
 
Name Accession Description Interval E-value
UBCc_UBE2Q cd23802
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, ...
 209-364 8.72e-80

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and related proteins; The E2Q subfamily includes mammalian ubiquitin-conjugating enzymes E2 Q1 (UBE2Q1/NICE5/UBE2Q), Q2 (UBE2Q2), and similar proteins. They are ubiquitin-conjugating (EC 2.3.2.23) enzymes that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2Q1 may be involved in hormonal homeostasis in females. It is involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation. In vitro, UBE2Q2 catalyzes 'Lys-48'-linked polyubiquitination. This subfamily also includes ubiquitin-conjugating enzyme E2Q-like protein 1 (UBE2QL1), which is a probable E2 ubiquitin-protein ligase that may facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.


Pssm-ID: 467422  Cd Length: 157  Bit Score: 241.38  E-value: 8.72e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691 209 DRLMKELREIYRSQSYKNGiYSVELLNDSLYDWHIKLRTVDPDSALHSDLQVLKEKEGMDYILLNFSYKDNFPFDPPFVR 288
Cdd:cd23802    1 KRLMKELKDLMKSQSKKLG-FSVDPVDDNLYHWEVKLFGFDPDSPLAKDLKKLKKKHGYDYIELELRFPDLYPFYPPFVR 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528508691 289 VVSPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGKARVQFGA--NKNQYNLARAQQSYKSLVQIH 364
Cdd:cd23802   80 VVRPRLKGGTGHVGGAICMELLTLSGWSPAYSIESVLLQIRALLVKGGARDDFSAraNKSPYSEAEARAAFKRLARIH 157
UBCc smart00212
Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for ...
 210-364 7.13e-19

Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. This pathway functions in regulating many fundamental processes required for cell viability.TSG101 is one of several UBC homologues that lacks this active site cysteine.


Pssm-ID: 214562 [Multi-domain]  Cd Length: 145  Bit Score: 82.34  E-value: 7.13e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691   210 RLMKELREIYRSQsyKNGIYSVELLNDSLYDWHIKLrtVDPDSALHsdlqvlkekEGMDYIL-LNFSykDNFPFDPPFVR 288
Cdd:smart00212   1 RLLKELKELRKDP--PPGFTAYPVDDENLLEWTGTI--VGPPGTPY---------EGGVFKLtIEFP--EDYPFKPPKVK 65

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528508691   289 VVSPVLsGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGKARvqFGANKNQYNLARA-QQSYKSLVQIH 364
Cdd:smart00212  66 FITKIY-HPNVDSSGEICLDILKQEKWSPALTLETVLLSLQSLLSEPNPD--SPLNADAAELYKKnREEFKKKAREW 139
UBCc_UEV cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain/ubiquitin E2 variant (UEV) domain; ...
 210-332 3.16e-15

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain/ubiquitin E2 variant (UEV) domain; The family includes ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain and ubiquitin (Ub) E2 variant (UEV) domain. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. E2 is part of the ubiquitin-mediated protein degradation pathway in which a thioester linkage forms between a conserved cysteine and the C-terminus of ubiquitin, and complexes with ubiquitin protein ligase enzymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form thioester linkages without the use of E3s. Several UBC homologs (TSG101, Mms2, Croc-1 and similar proteins) contains the UEV domain, which lacks the active site cysteine essential for ubiquitination and appear to function in DNA repair pathways.


Pssm-ID: 467407 [Multi-domain]  Cd Length: 112  Bit Score: 71.17  E-value: 3.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691 210 RLMKELREIyrsQSYKNGIYSVELLNDSLYDWHIKLrTVDPDSALHsdlqvlkekEGMDYILLNFSykDNFPFDPPFVRV 289
Cdd:cd00195    2 RLQKELKEL---QKNPPPGISVEPVDDDLFHWKATI-KGPEGTPYE---------GGVFKLDIEFP--DDYPFKPPKVRF 66

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 528508691 290 VSPVlsggY---VLGGGALCMELLTKQGWSSAYSIESVIMQINATL 332
Cdd:cd00195   67 LTPI----YhpnVDPDGEICLDILKSEGWSPALTLRSVLLSIQSLL 108
UBCc_invertebrate cd23955
ubiquitin-conjugating enzyme family protein; This subfamily includes ubiquitin-conjugating ...
 210-333 1.28e-14

ubiquitin-conjugating enzyme family protein; This subfamily includes ubiquitin-conjugating enzyme E2, catalytic (UBCc) domains mostly found in non-vertebrate eukaryotes. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. E2 is part of the ubiquitin-mediated protein degradation pathway in which a thioester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin protein ligase enzymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form thioester linkages without the use of E3s.


Pssm-ID: 467440 [Multi-domain]  Cd Length: 120  Bit Score: 69.59  E-value: 1.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691 210 RLMKELREIYRSQSykNGIySVELLNDSLYDWHIKLRTVD---PDSALHsdlqvlkekegmdyILLNFSykDNFPFDPPF 286
Cdd:cd23955    2 RLLRDLKELQEEPL--PGV-SAEPLENDLFEWHVNIRGPDgpySGVILH--------------LELTFP--EDYPNSPPS 62

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 528508691 287 VRVVSPVLSGGyVLGGGALCMELLT---------KQGWSSAYSIESVIMQINATLV 333
Cdd:cd23955   63 VRLLTPLPHPN-VFTGNYICLDMLEnfakhhskpYSGWSPAYTVQSILLQLQAFLF 117
UBCc_ScCDC34-like cd23811
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of Saccharomyces cerevisiae CDC34 and ...
 207-328 3.49e-11

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of Saccharomyces cerevisiae CDC34 and related proteins; Saccharomyces cerevisiae CDC34 (EC 2.3.2.23), also called ubiquitin-conjugating enzyme E2-34 kDa, cell division control protein 34, E2 ubiquitin-conjugating enzyme 3 (UBC3), DNA6, or ubiquitin ligase complex SCF subunit CDC34, catalyzes the covalent attachment of ubiquitin to other proteins. In vitro, it may ubiquitinate histone H2A. CDC34 mediates the initiation of DNA replication (transition of G1 to S phase in cell cycle). It is the catalytic subunit of an SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, CDC53, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation. Moreover, CDC34 is involved in the regulation of methionine biosynthesis genes and in the degradation of CDC6 together with CDC4 and CDC53.


Pssm-ID: 467431  Cd Length: 170  Bit Score: 61.30  E-value: 3.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691 207 ASDRLMKELREIYRSQSYKNgiYSVELLNDSLYDWHIKLRTVDPDSALHSdlqvlkekegmDYILLNFSYKDNFPFDPPF 286
Cdd:cd23811    1 AAKILMKEYKELTKPKTGPW--VHIELVNDNIFTWTVGLMVLNPDSIYNG-----------GYFKAEMVFPRDYPFSPPS 67

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528508691 287 VRVVSPVLSGGyVLGGGALCMELLTKQG------------WSSAYSIESVIMQI 328
Cdd:cd23811   68 FRFLPPIFHPN-VYPDGRLCISILHSPGddyqsgepaaerWSPAQTVESVLLSI 120
UQ_con pfam00179
Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ...
 210-332 6.28e-09

Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologs. TSG101 is one of several UBC homologs that lacks this active site cysteine.


Pssm-ID: 459701 [Multi-domain]  Cd Length: 139  Bit Score: 54.12  E-value: 6.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691  210 RLMKELREIyrsQSYKNGIYSVELLNDSLYDWHIKLrtVDPDSALHsdlqvlkekEGMDYILlNFSYKDNFPFDPPFVRV 289
Cdd:pfam00179   1 RLQKELKEL---LKDPPPGISAGPVDDNLFEWKVTI--IGPDGTPY---------EGGVFKL-SVEFPEDYPFKPPKVKF 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 528508691  290 VSPVlsggY---VLGGGALCMELLTKQGWSSAYSIESVIMQINATL 332
Cdd:pfam00179  66 TTKI----YhpnVDSSGEVCLDILKDERWSPALTLEQVLLSIQSLL 107
UBCc_TcUBE-like cd23828
Ubiquitin-conjugating enzyme E2, putative catalytic (UBCc) domain of Trypanosoma cruzi ...
 210-328 4.03e-08

Ubiquitin-conjugating enzyme E2, putative catalytic (UBCc) domain of Trypanosoma cruzi putative ubiquitin-conjugating enzyme E2 and related proteins; This subfamily includes uncharacterized Trypanosoma cruzi putative ubiquitin-conjugating enzyme E2 and similar proteins. They may function as ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins.


Pssm-ID: 467437  Cd Length: 121  Bit Score: 51.23  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691 210 RLMKELREIYRSQSYKNG-------IYSVEllNDSLYDWHIKLRTvDPDSALHSdlqvlkekeGMDYILLnFSYKDNFPF 282
Cdd:cd23828    2 RIGKDLRLLLESIKTGTEvdpagslIASVD--SDSLFHWRVVVKP-PANSIVYA---------GNTYELL-VIFSDDYPH 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 528508691 283 DPPFVRVVSPVLSGGyVLGGGALCMELLTKqGWSSAYSIESVIMQI 328
Cdd:cd23828   69 EPPKVRFLTPIYSPL-VSPEGSVCERLLED-DWKPTQHAADAIELV 112
UBCc_UBE2W cd23808
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin conjugating enzyme E2 W ...
 210-328 7.32e-07

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin conjugating enzyme E2 W and related enzymes; The E2W subfamily includes mammalian ubiquitin-conjugating enzymes E2 W (UBE2W/UBC16), plant ubiquitin-conjugating enzyme E2 15-18 (UBC15-18), and similar proteins. They are ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2W, also called FLJ11011, E2 ubiquitin-conjugating enzyme W, N-terminal E2 ubiquitin-conjugating enzyme (EC 2.3.2.25), N-terminus-conjugating E2, ubiquitin carrier protein W, ubiquitin-conjugating enzyme 16 (UBC-16), or ubiquitin-protein ligase W, specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. In vitro, UBE2W catalyzes 'Lys-11'-linked polyubiquitination. UBE2W is an important protein for early postnatal survival and for the normal functioning of multiple organ systems.


Pssm-ID: 467428 [Multi-domain]  Cd Length: 119  Bit Score: 47.52  E-value: 7.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691 210 RLMKELREIyrSQSYKNGIySVELLNDSLYDWHIKLrTVDPDSALhsdlqvlkekEGMDYiLLNFSYKDNFPFDPP---F 286
Cdd:cd23808    3 RLQKELKEL--QKNPPPGI-TLDVADNNLTEWIVTI-EGAPGTLY----------EGEKF-RLRFKFPPDYPIESPevvF 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 528508691 287 VRVVSP----VLSGGYVlgggalCMELLTkQGWSSAYSIESVIMQI 328
Cdd:cd23808   68 VGPPIPvhphVYSNGHI------CLSILY-DDWSPALTVSSVCLSI 106
PLN00172 PLN00172
ubiquitin conjugating enzyme; Provisional
 207-355 1.01e-05

ubiquitin conjugating enzyme; Provisional


Pssm-ID: 177768 [Multi-domain]  Cd Length: 147  Bit Score: 45.13  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691 207 ASDRLMKELREIYRSQSYKngiYSVELLNDSLYDWHIKLrtVDPDSALHSDlqvlkekegmDYILLNFSYKDNFPFDPPF 286
Cdd:PLN00172   2 ATKRIQKEHKDLLKDPPSN---CSAGPSDENLFRWTASI--IGPSDSPYAG----------GVFFLSILFPPDYPFKPPK 66

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528508691 287 VRVVSPVLSGGyVLGGGALCMELLTKQgWSSAYSIESVIMQINA---------TLVKGKARVqFGANKNQYNlARAQQ 355
Cdd:PLN00172  67 VQFTTKIYHPN-INSNGSICLDILRDQ-WSPALTVSKVLLSISSlltdpnpddPLVPEIARV-FKENRSRYE-ATARE 140
UBCc_SpUBC14-like cd23815
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of Schizosaccharomyces pombe UBC14 ...
 210-328 1.04e-05

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of Schizosaccharomyces pombe UBC14 and related proteins; Schizosaccharomyces pombe UBC14 (EC 2.3.2.23), also called ubiquitin-conjugating enzyme E2 14, E2 ubiquitin-conjugating enzyme 14, ubiquitin carrier protein 14, or ubiquitin-protein ligase 14, acts as a ubiquitin-conjugating enzyme that catalyzes the covalent attachment of ubiquitin to other proteins. It mediates the selective degradation of short-lived and abnormal proteins.


Pssm-ID: 467435  Cd Length: 143  Bit Score: 44.97  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691 210 RLMKELREIyrsQSYKNGIYSVELLNDSLYDWHIklrtvdpdsalhsdlqVLKEKEGMDY----ILLNFSYKDNFPFDPP 285
Cdd:cd23815    2 RIQKELADL---QKNPIAGISAGPVEDNLFEWKG----------------TILGPVGSPYeggiFKFKITFPEDYPFKPP 62

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 528508691 286 FVRVVSPVlsggY---VLGGGALCMELLTKQGWSSAYSIESVIMQI 328
Cdd:cd23815   63 TVKFTTKI----YhpnVDDDGSICLGILKSDAWKPSIKLVSVLNAL 104
UEV_Morgue-like cd23826
ubiquitin E2 variant (UEV) domain of Drosophila melanogaster Morgue and related proteins; ...
 210-332 3.91e-05

ubiquitin E2 variant (UEV) domain of Drosophila melanogaster Morgue and related proteins; Morgue is an F-box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis. It contains both an F-box and a UEV domain that is homologous to E2 ubiquitin ligases but lacks the conserved cysteine residue required for catalytic activity.


Pssm-ID: 467436 [Multi-domain]  Cd Length: 147  Bit Score: 43.38  E-value: 3.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691 210 RLMKELREIYrsQSYKNGIYSVELLNDSLYDWhikLRTVD--PDSALhsdlqvlkeKEGMDYILLNFsyKDNFPFDPPFV 287
Cdd:cd23826    5 RLRRELKALH--SDDPPEGISARPLDRSLLHL---LATIEgpPGSPY---------EGGIFFLRIQI--PESYPFRPPKV 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 528508691 288 RVVSPVlsggY---VLGGGALCMELLTKQgWSSAYSIESVIMQINATL 332
Cdd:cd23826   69 RFLTKI----YhpnISRHGDICLDILEHN-WSLALTIEKVLISIQSLL 111
UBCc_ScPEX4-like cd23812
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of Saccharomyces cerevisiae Peroxin-4 ...
 210-332 6.43e-05

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of Saccharomyces cerevisiae Peroxin-4 (PEX4) protein and related proteins; Saccharomyces cerevisiae PEX4 (EC 2.3.2.23), also called ubiquitin-conjugating enzyme E2-21 kDa, UBC10, or PAS2, acts as a ubiquitin-conjugating enzyme that catalyzes the covalent attachment of ubiquitin to other proteins. It is essential for peroxisome biogenesis and is required for UBC4-independent ubiquitination of PEX5. This subfamily also includes Arabidopsis thaliana PEX4 (also known as UBC21, EC 2.3.2.23) that is required for peroxisome biogenesis. It is necessary for the developmental elimination of obsolete peroxisome matrix proteins. It may be involved in the ubiquitination of PEX5, targeting it for recycling.


Pssm-ID: 467432 [Multi-domain]  Cd Length: 145  Bit Score: 42.54  E-value: 6.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691 210 RLMKELREIYRSQSykngiysvellndslyDWHIKLRTVDPDSALHSDlQVLKEKEGMDY----ILLNFSYKDNFPFDPP 285
Cdd:cd23812    2 RLLKELRELQKEPN----------------DPDIVLGPVEDDDLFRWE-AVIKGPKDTPYeggrFELAIQVPSNYPISPP 64

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 528508691 286 FVRVVSPVLSGGYVLGGGALCMELLtKQGWSSAYSIESVIMQINATL 332
Cdd:cd23812   65 KVKFVTKIFHPNVHFKTGEICLDIL-KTAWSPAWTLQSVCRAILALL 110
UBCc_UBE2F_UBE2M cd23794
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin conjugating enzymes E2 F, ...
 273-332 4.85e-04

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin conjugating enzymes E2 F, E2 M and related proteins; The E2F/E2M subfamily includes mammalian ubiquitin-conjugating enzymes E2 F (UBE2F/NCE2, EC 2.3.2.32) and E2 M (UBE2M/UBC12, EC 2.3.2.34), yeast NEDD8-conjugating enzyme UBC12 (EC 2.3.2.24), plant RUB1-conjugating enzyme 1-2 (RCE1/UBC12 and RCE2/UBC12L, EC 2.3.2.-), and similar proteins. UBE2F (also called EDD8-conjugating enzyme UBE2F, NEDD8 carrier protein UBE2F, NEDD8 protein ligase UBE2F, NEDD8-conjugating enzyme 2, or RING-type E3 NEDD8 transferase UBE2F) and UBE2M (also called NEDD8-conjugating enzyme UBC12, or NEDD8 carrier protein) accept the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. The RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. UBE2M is involved in cell proliferation. Saccharomyces cerevisiae UBC12 and Arabidopsis thaliana RCE1/RCE2 accept the ubiquitin-like protein NEDD8/RUB1 from the UBA3-ULA1 E1 complex and the ECR1-AXR1 E1 complex, respectively.


Pssm-ID: 467414  Cd Length: 138  Bit Score: 39.85  E-value: 4.85e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528508691 273 NFSYKDNFPFDPPFVRVVSPVlsggY---VLGGGALCMELLtKQGWSSAYSIESVIMQINATL 332
Cdd:cd23794   51 EIDIPDNYPFEPPKVKCLTKI----YhpnIDEEGNVCLNIL-REDWKPVLSLKDVILGLLFLF 108
UBCc_UBE2C cd23791
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 C ...
 265-332 3.03e-03

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 C and related proteins; The E2C family includes mammalian ubiquitin-conjugating enzyme E2 C (UBE2C/UBCH10), yeast E2 ubiquitin-conjugating enzyme 11 (UBC11), plant ubiquitin-conjugating enzyme E2 19 (UBC19) and 20 (UBC20). They are ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2C, also known as (E3-independent) E2 ubiquitin-conjugating enzyme C (EC 2.3.2.24), E2 ubiquitin-conjugating enzyme C, ubiquitin carrier protein C, or ubiquitin-protein ligase C, catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination in vitro. It is a ubiquitin carrier protein required for the destruction of mitotic cyclins and proteins that maintain sister chromatid cohesion in animal cells and in Schizosaccharomyces pombe. In Saccharomyces cerevisiae, UBC11 is not essential for mitotic cyclin destruction. Arabidopsis thaliana UBC19 is part of the anaphase-promoting complex (APC). It may have a key function during cell cycle and be involved in cyclin B1 degradation.


Pssm-ID: 467411  Cd Length: 140  Bit Score: 37.55  E-value: 3.03e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528508691 265 EGMDYIL-LNFSykDNFPFDPPFVRVVSPVlsggY---VLGGGALCMELLtKQGWSSAYSIESVIMQINATL 332
Cdd:cd23791   44 EGLKYKLsLEFP--SNYPYKAPTVKFETPC----FhpnVDQHGNICLDIL-KEKWSALYDVRTILLSIQSLL 108
UBCc_UBE2L3 cd23801
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 L3, ...
 207-332 5.17e-03

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 L3, L5, L6 and related proteins; The E2L3-like subfamily includes mammalian ubiquitin-conjugating enzymes E2 L3 (UBE2L3/UBCH7/UBCE7), L5 (UBE2L5), L6 (UBE2L6/UBCH8), and similar proteins. They are ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2L3 specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. It does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like RING-HECT hybrids. In vitro, UBE2L3 catalyzes 'Lys-11'-linked polyubiquitination. It is involved in the selective degradation of short-lived and abnormal proteins. In addition to ubiquitin, UBE2L6 also catalyzes the covalent attachment of ISG15 to other proteins. It functions in the E6/E6-AP-induced ubiquitination of p53/TP53. It promotes ubiquitination and subsequent proteasomal degradation of FLT3.


Pssm-ID: 467421  Cd Length: 147  Bit Score: 37.25  E-value: 5.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528508691 207 ASDRLMKELREIYRSQsyKNGIYSVELLNDSLYDWHIklrTVDPDSALHSdlqvlkekEGMDYILLNFSykDNFPFDPPF 286
Cdd:cd23801    1 ASRRLQKELEELRKSG--PKYFRDLSVDESNVLKWTG---LLVPDNPPYN--------KGAFRIEITFP--AEYPFKPPK 65

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 528508691 287 VRVVSPVlsggY---VLGGGALCMELLTKQGWSSAYSIESVIMQINATL 332
Cdd:cd23801   66 ITFKTKI----YhpnVDEKGQVCLPIISPENWKPATKIDQVLQALLALI 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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