NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|528487610|ref|XP_005167067|]
View 

tpd52 like 2a isoform X1 [Danio rerio]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPD52 super family cl09558
Tumour protein D52 family; The hD52 gene was originally identified through its elevated ...
 36-190 3.90e-35

Tumour protein D52 family; The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologs from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologs of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.


The actual alignment was detected with superfamily member pfam04201:

Pssm-ID: 461225  Cd Length: 99  Bit Score: 120.25  E-value: 3.90e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528487610   36 LIKVEDEIETLRQVLVAKERHAAELKHRLGISPLSEIKQNITKGWHDVQCSNAYMRtsqtlgdlnrrvtssnlyltasat 115
Cdd:pfam04201  13 LTKLEEEIVTLRQVLAAKEKHCAELKRKLGLTPLVELKQNLSKSWHDVQVSNAYKK------------------------ 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528487610  116 ledigrsdaykrtqetlsqagQVTSAAFSSMGSAIRSRFGEmralpysdsgsnlsmrhslsmpaMRNSPSFKSFE 190
Cdd:pfam04201  69 ---------------------QKTSAALSTVGSAICRKLGD-----------------------MRNSPTFKSFE 99
 
Name Accession Description Interval E-value
TPD52 pfam04201
Tumour protein D52 family; The hD52 gene was originally identified through its elevated ...
 36-190 3.90e-35

Tumour protein D52 family; The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologs from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologs of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.


Pssm-ID: 461225  Cd Length: 99  Bit Score: 120.25  E-value: 3.90e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528487610   36 LIKVEDEIETLRQVLVAKERHAAELKHRLGISPLSEIKQNITKGWHDVQCSNAYMRtsqtlgdlnrrvtssnlyltasat 115
Cdd:pfam04201  13 LTKLEEEIVTLRQVLAAKEKHCAELKRKLGLTPLVELKQNLSKSWHDVQVSNAYKK------------------------ 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528487610  116 ledigrsdaykrtqetlsqagQVTSAAFSSMGSAIRSRFGEmralpysdsgsnlsmrhslsmpaMRNSPSFKSFE 190
Cdd:pfam04201  69 ---------------------QKTSAALSTVGSAICRKLGD-----------------------MRNSPTFKSFE 99
 
Name Accession Description Interval E-value
TPD52 pfam04201
Tumour protein D52 family; The hD52 gene was originally identified through its elevated ...
 36-190 3.90e-35

Tumour protein D52 family; The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologs from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologs of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.


Pssm-ID: 461225  Cd Length: 99  Bit Score: 120.25  E-value: 3.90e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528487610   36 LIKVEDEIETLRQVLVAKERHAAELKHRLGISPLSEIKQNITKGWHDVQCSNAYMRtsqtlgdlnrrvtssnlyltasat 115
Cdd:pfam04201  13 LTKLEEEIVTLRQVLAAKEKHCAELKRKLGLTPLVELKQNLSKSWHDVQVSNAYKK------------------------ 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528487610  116 ledigrsdaykrtqetlsqagQVTSAAFSSMGSAIRSRFGEmralpysdsgsnlsmrhslsmpaMRNSPSFKSFE 190
Cdd:pfam04201  69 ---------------------QKTSAALSTVGSAICRKLGD-----------------------MRNSPTFKSFE 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH