NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|528476207|ref|XP_005164711|]
View 

protein arginine N-methyltransferase 8-B isoform X1 [Danio rerio]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 1905023)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
112-275 2.52e-42

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 148.65  E-value: 2.52e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 112 HEEMLKDEVRTLTYRNSMYHnkHIFKDKIVLDVGSGTGILSMFAAKAGAKHVYGIECS-SISEYSEKIIKSNHLDSVITI 190
Cdd:COG4076   12 HHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNpDIAAVARRIIAANGLSDRITV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 191 LKGKVEETELPvDQVDIIISEWMGYCLFYESMLNTVIYARDKWLKPGGFMFPDRATLYVVAIEDRQYKDFKIHWweNVYG 270
Cdd:COG4076   90 INADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDW--QFDG 166


                 ....*
gi 528476207 271 FDMTC 275
Cdd:COG4076  167 FDFRL 171
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
112-275 2.52e-42

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 148.65  E-value: 2.52e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 112 HEEMLKDEVRTLTYRNSMYHnkHIFKDKIVLDVGSGTGILSMFAAKAGAKHVYGIECS-SISEYSEKIIKSNHLDSVITI 190
Cdd:COG4076   12 HHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNpDIAAVARRIIAANGLSDRITV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 191 LKGKVEETELPvDQVDIIISEWMGYCLFYESMLNTVIYARDKWLKPGGFMFPDRATLYVVAIEDRQYKDFKIHWweNVYG 270
Cdd:COG4076   90 INADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDW--QFDG 166


                 ....*
gi 528476207 271 FDMTC 275
Cdd:COG4076  167 FDFRL 171
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 141-241 8.69e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 61.29  E-value: 8.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 141 VLDVGSGTGILSMFAAKAGAKHVYGIECSSISEYSEKIIKSNHLDSVITILKGKVEE-TELPVDQVDIIISeWMGYCLFY 219
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEElPPEADESFDVIIS-DPPLHHLV 80

                         90       100
                 ....*....|....*....|..
gi 528476207 220 ESMLNTVIYARDKwLKPGGFMF 241
Cdd:cd02440   81 EDLARFLEEARRL-LKPGGVLV 101
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 141-238 5.56e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 58.73  E-value: 5.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207  141 VLDVGSGTGILSMFAAKAGAKHVYGIECSSIS-EYSEKIIKSNHLDsvITILKGKVEETELPVDQVDIIISeWMGYCLFY 219
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMlERARERAAEAGLN--VEFVQGDAEDLPFPDGSFDLVVS-SGVLHHLP 77

                          90       100
                  ....*....|....*....|.
gi 528476207  220 ESMLNTVI--YARdkWLKPGG 238
Cdd:pfam13649  78 DPDLEAALreIAR--VLKPGG 96
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
133-238 1.08e-08

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 55.54  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 133 KHIFKDKIVLDVGSGTGILSMFAAKAGAKHVYGIECSSIS-EYSEKIIKSNHLDSVITILKGkveetELPVDQV------ 205
Cdd:PRK00517 115 KLVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAvEAARENAELNGVELNVYLPQG-----DLKADVIvanila 189

                         90       100       110
                 ....*....|....*....|....*....|...
gi 528476207 206 DIIIsewmgyclfyesMLNTVIYARdkwLKPGG 238
Cdd:PRK00517 190 NPLL------------ELAPDLARL---LKPGG 207
tly TIGR00478
TlyA family rRNA methyltransferase/putative hemolysin; Members of this family include TlyA ...
 136-178 5.53e-05

TlyA family rRNA methyltransferase/putative hemolysin; Members of this family include TlyA from Mycobacterium tuberculosis, an rRNA methylase whose modifications are necessary to confer sensitivity to ribosome-targeting antibiotics capreomycin and viomycin. Homology supports identification as a methyltransferase. However, a parallel literature persists in calling some members hemolysins. Hemolysins are exotoxins that attack blood cell membranes and cause cell rupture, often by forming a pore in the membrane. A recent study (2013) on SCO1782 from Streptomyces coelicolor shows hemolysin activity as earlier described for a homolog from the spirochete Serpula (Treponema) hyodysenteriae and one from Mycobacterium tuberculosis. [Unknown function, General]


Pssm-ID: 129570 [Multi-domain]  Cd Length: 228  Bit Score: 44.41  E-value: 5.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 528476207  136 FKDKIVLDVGSGTGILSMFAAKAGAKHVYGIECsSISEYSEKI 178
Cdd:TIGR00478  74 VKNKIVLDVGSSTGGFTDCALQKGAKEVYGVDV-GYNQLAEKL 115
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
112-275 2.52e-42

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 148.65  E-value: 2.52e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 112 HEEMLKDEVRTLTYRNSMYHnkHIFKDKIVLDVGSGTGILSMFAAKAGAKHVYGIECS-SISEYSEKIIKSNHLDSVITI 190
Cdd:COG4076   12 HHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNpDIAAVARRIIAANGLSDRITV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 191 LKGKVEETELPvDQVDIIISEWMGYCLFYESMLNTVIYARDKWLKPGGFMFPDRATLYVVAIEDRQYKDFKIHWweNVYG 270
Cdd:COG4076   90 INADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDW--QFDG 166


                 ....*
gi 528476207 271 FDMTC 275
Cdd:COG4076  167 FDFRL 171
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
133-209 7.70e-12

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 65.58  E-value: 7.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 133 KHIFKDKIVLDVGSGTGILSMFAAKAGAKHVYGIEcssISEYSEKIIKS----NHLDSVITILKGKVEETElpvdQVDII 208
Cdd:COG2264  144 KLLKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVD---IDPVAVEAAREnaelNGVEDRIEVVLGDLLEDG----PYDLV 216


                 .
gi 528476207 209 I 209
Cdd:COG2264  217 V 217
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 141-241 8.69e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 61.29  E-value: 8.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 141 VLDVGSGTGILSMFAAKAGAKHVYGIECSSISEYSEKIIKSNHLDSVITILKGKVEE-TELPVDQVDIIISeWMGYCLFY 219
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEElPPEADESFDVIIS-DPPLHHLV 80

                         90       100
                 ....*....|....*....|..
gi 528476207 220 ESMLNTVIYARDKwLKPGGFMF 241
Cdd:cd02440   81 EDLARFLEEARRL-LKPGGVLV 101
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 132-241 5.55e-11

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 59.65  E-value: 5.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 132 NKHIFKDKIVLDVGSGTGILSMFAAKAGAkHVYGIEcssISEYSEKIIKSNHLDSVITILKGKVEETELPVDQVDIIISe 211
Cdd:COG2227   19 ARLLPAGGRVLDVGCGTGRLALALARRGA-DVTGVD---ISPEALEIARERAAELNVDFVQGDLEDLPLEDGSFDLVIC- 93

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 528476207 212 wmgyclfyesmLNTVIYARD---------KWLKPGGFMF 241
Cdd:COG2227   94 -----------SEVLEHLPDpaallrelaRLLKPGGLLL 121
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 141-238 5.56e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 58.73  E-value: 5.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207  141 VLDVGSGTGILSMFAAKAGAKHVYGIECSSIS-EYSEKIIKSNHLDsvITILKGKVEETELPVDQVDIIISeWMGYCLFY 219
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMlERARERAAEAGLN--VEFVQGDAEDLPFPDGSFDLVVS-SGVLHHLP 77

                          90       100
                  ....*....|....*....|.
gi 528476207  220 ESMLNTVI--YARdkWLKPGG 238
Cdd:pfam13649  78 DPDLEAALreIAR--VLKPGG 96
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
133-238 1.08e-08

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 55.54  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 133 KHIFKDKIVLDVGSGTGILSMFAAKAGAKHVYGIECSSIS-EYSEKIIKSNHLDSVITILKGkveetELPVDQV------ 205
Cdd:PRK00517 115 KLVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAvEAARENAELNGVELNVYLPQG-----DLKADVIvanila 189

                         90       100       110
                 ....*....|....*....|....*....|...
gi 528476207 206 DIIIsewmgyclfyesMLNTVIYARdkwLKPGG 238
Cdd:PRK00517 190 NPLL------------ELAPDLARL---LKPGG 207
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 142-241 3.97e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 50.74  E-value: 3.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207  142 LDVGSGTGILSMFAAKAGAkHVYGIEcssISEYSEKIIKSNHLDSVITILKGKVEETELPVDQVDIIISEWMgycLFYES 221
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVD---ISPEMLELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEV---LHHVE 73

                          90       100
                  ....*....|....*....|
gi 528476207  222 MLNTVIYARDKWLKPGGFMF 241
Cdd:pfam08241  74 DPERALREIARVLKPGGILI 93
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 137-209 1.32e-07

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 52.65  E-value: 1.32e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528476207  137 KDKIVLDVGSGTGILSMFAAKAGAKHVYGIEcssISEYSEKIIKSN-HLDSVITILKGKVEEtELPVDQVDIII 209
Cdd:pfam06325 161 PGESVLDVGCGSGILAIAALKLGAKKVVGVD---IDPVAVRAAKENaELNGVEARLEVYLPG-DLPKEKADVVV 230
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 141-241 2.07e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 50.31  E-value: 2.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 141 VLDVGSGTGILSMFAAKAGAKHVYGIecsSIS----EYSEKIIKSNHLDSVITILKGKVEETELPvDQVDIIIS----EW 212
Cdd:COG2230   55 VLDIGCGWGGLALYLARRYGVRVTGV---TLSpeqlEYARERAAEAGLADRVEVRLADYRDLPAD-GQFDAIVSigmfEH 130

                         90       100
                 ....*....|....*....|....*....
gi 528476207 213 MGYcLFYESMLNTViyarDKWLKPGGFMF 241
Cdd:COG2230  131 VGP-ENYPAYFAKV----ARLLKPGGRLL 154
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
136-210 1.12e-06

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 48.75  E-value: 1.12e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528476207 136 FKDKIVLDVGSGTGILSMFAAKAGAKHVYGIEcssISEYSEKIIKSNH--LDSVITILKGKVEETELpVDQVDIIIS 210
Cdd:COG2263   44 IEGKTVLDLGCGTGMLAIGAALLGAKKVVGVD---IDPEALEIARENAerLGVRVDFIRADVTRIPL-GGSVDTVVM 116
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 141-247 4.87e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 46.14  E-value: 4.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 141 VLDVGSGTGILSMFAAKAGAkHVYGIEcssISEYSEKIIKSNHLDSV--ITILKGKVEETELPVDQVDIIISewmGYCLF 218
Cdd:COG2226   26 VLDLGCGTGRLALALAERGA-RVTGVD---ISPEMLELARERAAEAGlnVEFVVGDAEDLPFPDGSFDLVIS---SFVLH 98

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 528476207 219 Y----ESMLNTViyARdkWLKPGG------FMFPDRATL 247
Cdd:COG2226   99 HlpdpERALAEI--AR--VLKPGGrlvvvdFSPPDLAEL 133
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 141-210 4.91e-06

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 47.45  E-value: 4.91e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528476207 141 VLDVGSGTGILS-MFAAKAGAKHVYGIECSSIS-EYSEKIIKSNHLDSVITILKGKVEE--TELPVDQVDIIIS 210
Cdd:COG4123   41 VLDLGTGTGVIAlMLAQRSPGARITGVEIQPEAaELARRNVALNGLEDRITVIHGDLKEfaAELPPGSFDLVVS 114
tly TIGR00478
TlyA family rRNA methyltransferase/putative hemolysin; Members of this family include TlyA ...
 136-178 5.53e-05

TlyA family rRNA methyltransferase/putative hemolysin; Members of this family include TlyA from Mycobacterium tuberculosis, an rRNA methylase whose modifications are necessary to confer sensitivity to ribosome-targeting antibiotics capreomycin and viomycin. Homology supports identification as a methyltransferase. However, a parallel literature persists in calling some members hemolysins. Hemolysins are exotoxins that attack blood cell membranes and cause cell rupture, often by forming a pore in the membrane. A recent study (2013) on SCO1782 from Streptomyces coelicolor shows hemolysin activity as earlier described for a homolog from the spirochete Serpula (Treponema) hyodysenteriae and one from Mycobacterium tuberculosis. [Unknown function, General]


Pssm-ID: 129570 [Multi-domain]  Cd Length: 228  Bit Score: 44.41  E-value: 5.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 528476207  136 FKDKIVLDVGSGTGILSMFAAKAGAKHVYGIECsSISEYSEKI 178
Cdd:TIGR00478  74 VKNKIVLDVGSSTGGFTDCALQKGAKEVYGVDV-GYNQLAEKL 115
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 141-239 1.06e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 42.98  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 141 VLDVGSGTGILSMFAAKAGAKHVYGIECSSIS-EYSEKIIKSNHLDSViTILKGKVEET-ELPVDQVDIIISEwmgYCLF 218
Cdd:COG0500   30 VLDLGCGTGRNLLALAARFGGRVIGIDLSPEAiALARARAAKAGLGNV-EFLVADLAELdPLPAESFDLVVAF---GVLH 105

                         90       100
                 ....*....|....*....|...
gi 528476207 219 YESMLNTVIYARD--KWLKPGGF 239
Cdd:COG0500  106 HLPPEEREALLRElaRALKPGGV 128
PRK14968 PRK14968
putative methyltransferase; Provisional
 137-217 1.73e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 42.19  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 137 KDKIVLDVGSGTGILSMFAAKAGAKhvygIECSSISEYSEKIIKSNHLDSVITILKGKVEETEL--PV--DQVDIII--- 209
Cdd:PRK14968  23 KGDRVLEVGTGSGIVAIVAAKNGKK----VVGVDINPYAVECAKCNAKLNNIRNNGVEVIRSDLfePFrgDKFDVILfnp 98

                         90
                 ....*....|....*....
gi 528476207 210 -----------SEWMGYCL 217
Cdd:PRK14968  99 pylpteeeeewDDWLNYAL 117
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 132-239 7.22e-04

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 40.73  E-value: 7.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207  132 NKHIFKDKIVLDVGSGTGILS-MFAAKAGAKHVYGIEcssISEYSEKIIKSnHLDSVITILKGKVEETELPVDQVDIIIS 210
Cdd:TIGR02072  29 EKGIFIPASVLDIGCGTGYLTrALLKRFPQAEFIALD---ISAGMLAQAKT-KLSENVQFICGDAEKLPLEDSSFDLIVS 104

                          90       100       110
                  ....*....|....*....|....*....|...
gi 528476207  211 ----EWMGyclfyesMLNTVIYARDKWLKPGGF 239
Cdd:TIGR02072 105 nlalQWCD-------DLSQALSELARVLKPGGL 130
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 135-210 2.75e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 38.17  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207  135 IFKDKIVLDVGSGTGILSMFAAK--AGAKHVYGIECSSIS-EYSEKIIKSNHLDSViTILKGKVEE--TELPVDQVDIII 209
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEelGPNAEVVGIDISEEAiEKARENAQKLGFDNV-EFEQGDIEElpELLEDDKFDVVI 79


                  .
gi 528476207  210 S 210
Cdd:pfam13847  80 S 80
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 134-266 3.23e-03

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 38.52  E-value: 3.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207 134 HIFKDKIVLDVGSGTGILSMFAAKAGAKHVYGIEcssISEYSEKIIKSN----HLDSVITILKGKVEE--TELPVDQVDI 207
Cdd:COG0742   38 PDIEGARVLDLFAGSGALGLEALSRGAASVVFVE---KDRKAAAVIRKNleklGLEDRARVIRGDALRflKRLAGEPFDL 114

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528476207 208 IisewmgyclF---------YESMLNTViyARDKWLKPGGFM---------FPDRATLYVVaIEDRQYKDFKIHWWE 266
Cdd:COG0742  115 V---------FldppyakglLEKALELL--AENGLLAPGGLIvvehskreeLPELPAGLEL-LKERKYGDTRLSFYR 179
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
96-241 6.22e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 37.67  E-value: 6.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476207  96 MTSRDY---YFDSYAHfgIHEEMLkdeVRTLTYRNSMYHNKHIF------KDKIVLDVGSGTGILSMFAAKAGaKHVYGI 166
Cdd:COG4976    1 MALDAYveaLFDQYAD--SYDAAL---VEDLGYEAPALLAEELLarlppgPFGRVLDLGCGTGLLGEALRPRG-YRLTGV 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528476207 167 ECSS--ISEYSEKIIKsnhldsvITILKGKVEETELPVDQVDIIISeWMGYClfYESMLNTVIYARDKWLKPGG-FMF 241
Cdd:COG4976   75 DLSEemLAKAREKGVY-------DRLLVADLADLAEPDGRFDLIVA-ADVLT--YLGDLAAVFAGVARALKPGGlFIF 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH