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Conserved domains on  [gi|528517546|ref|XP_005162089|]
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tpd52 like 2b isoform X4 [Danio rerio]

Protein Classification

D52 family tumor protein( domain architecture ID 10514819)

D52 family tumor protein similar to Homo sapiens tumor protein D52 (TPD52) that may play roles in calcium-mediated signal transduction and cell proliferation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPD52 pfam04201
Tumour protein D52 family; The hD52 gene was originally identified through its elevated ...
 56-190 1.42e-42

Tumour protein D52 family; The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologs from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologs of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.


:

Pssm-ID: 461225  Cd Length: 99  Bit Score: 139.13  E-value: 1.42e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528517546   56 TKVEEEINTLRQVLSAKERHASELKRKLGLSPLTEFKQNITKSWQDVQTSNAylsasstldditssevYKKtqetlsqag 135
Cdd:pfam04201  14 TKLEEEIVTLRQVLAAKEKHCAELKRKLGLTPLVELKQNLSKSWHDVQVSNA----------------YKK--------- 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 528517546  136 QKTSAALSTVGTAISRKLGDmralpfsnsfgsnysirhsismptMRNSPTFKSFE 190
Cdd:pfam04201  69 QKTSAALSTVGSAICRKLGD------------------------MRNSPTFKSFE 99
 
Name Accession Description Interval E-value
TPD52 pfam04201
Tumour protein D52 family; The hD52 gene was originally identified through its elevated ...
 56-190 1.42e-42

Tumour protein D52 family; The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologs from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologs of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.


Pssm-ID: 461225  Cd Length: 99  Bit Score: 139.13  E-value: 1.42e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528517546   56 TKVEEEINTLRQVLSAKERHASELKRKLGLSPLTEFKQNITKSWQDVQTSNAylsasstldditssevYKKtqetlsqag 135
Cdd:pfam04201  14 TKLEEEIVTLRQVLAAKEKHCAELKRKLGLTPLVELKQNLSKSWHDVQVSNA----------------YKK--------- 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 528517546  136 QKTSAALSTVGTAISRKLGDmralpfsnsfgsnysirhsismptMRNSPTFKSFE 190
Cdd:pfam04201  69 QKTSAALSTVGSAICRKLGD------------------------MRNSPTFKSFE 99
 
Name Accession Description Interval E-value
TPD52 pfam04201
Tumour protein D52 family; The hD52 gene was originally identified through its elevated ...
 56-190 1.42e-42

Tumour protein D52 family; The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologs from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologs of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.


Pssm-ID: 461225  Cd Length: 99  Bit Score: 139.13  E-value: 1.42e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528517546   56 TKVEEEINTLRQVLSAKERHASELKRKLGLSPLTEFKQNITKSWQDVQTSNAylsasstldditssevYKKtqetlsqag 135
Cdd:pfam04201  14 TKLEEEIVTLRQVLAAKEKHCAELKRKLGLTPLVELKQNLSKSWHDVQVSNA----------------YKK--------- 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 528517546  136 QKTSAALSTVGTAISRKLGDmralpfsnsfgsnysirhsismptMRNSPTFKSFE 190
Cdd:pfam04201  69 QKTSAALSTVGSAICRKLGD------------------------MRNSPTFKSFE 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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