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Conserved domains on  [gi|528514080|ref|XP_005161355|]
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beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1 [Danio rerio]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 217-482 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467713  Cd Length: 266  Bit Score: 557.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 217 GPEILCEIKEKVQVTTLTPDMEPFSGFPWGSQLPPRQITSDVGPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPT 296
Cdd:cd23985    1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 297 AGFETDVGSKTTVRLINSQLMASEDHHFLSSSLYSAGILVSWDPSPYSSDLWEWFNKTDYPIFKQYQRYRRLHPQQPFYI 376
Cdd:cd23985   81 AGFQQDVGTKTTIRLINSQLVTTEKHKFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 377 VHPRMEWQLWQRIQDNMGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTELCHYYQRFSDAACTLGAYHPLLYE 456
Cdd:cd23985  161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                        250       260
                 ....*....|....*....|....*.
gi 528514080 457 KNLVKRMNQGSDRDIYTLGRVTLPGF 482
Cdd:cd23985  241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
 
Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 217-482 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 557.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 217 GPEILCEIKEKVQVTTLTPDMEPFSGFPWGSQLPPRQITSDVGPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPT 296
Cdd:cd23985    1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 297 AGFETDVGSKTTVRLINSQLMASEDHHFLSSSLYSAGILVSWDPSPYSSDLWEWFNKTDYPIFKQYQRYRRLHPQQPFYI 376
Cdd:cd23985   81 AGFQQDVGTKTTIRLINSQLVTTEKHKFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 377 VHPRMEWQLWQRIQDNMGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTELCHYYQRFSDAACTLGAYHPLLYE 456
Cdd:cd23985  161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                        250       260
                 ....*....|....*....|....*.
gi 528514080 457 KNLVKRMNQGSDRDIYTLGRVTLPGF 482
Cdd:cd23985  241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 260-465 3.56e-33

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 126.57  E-value: 3.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080  260 PFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLIN--SqLMASEDHHFLSSSLYSAGIL-V 336
Cdd:pfam00777  42 RCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeS-AIDSKYGNLGFSHPRDPFVEfV 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080  337 SwdpSPYSSDLWEW-----FNKTDYPIFKQYQRYRRLH-PQQP--FYIVHPR-MEW--QLWQRiqdnmGEAIQKNPPSSG 405
Cdd:pfam00777 121 L---VPFKGRDLLWlpaflTKGNVSRSLRVLYTLKEVKiPVDPdkVLFLHPDfLRYvaNFWLR-----SHGLKGRRPSTG 192

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528514080  406 LLGTVLMMSLCEVVHVYEFLP--SRRKTELcHYYQRFSDAACTLGAYHPLLYEKNLVKRMNQ 465
Cdd:pfam00777 193 LLMLSLALHLCDEVSLYGFGPflDSRGNSH-HYYDNVLMKKGGFYGVHDMPFEFKLLQKLHK 253
 
Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 217-482 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 557.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 217 GPEILCEIKEKVQVTTLTPDMEPFSGFPWGSQLPPRQITSDVGPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPT 296
Cdd:cd23985    1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 297 AGFETDVGSKTTVRLINSQLMASEDHHFLSSSLYSAGILVSWDPSPYSSDLWEWFNKTDYPIFKQYQRYRRLHPQQPFYI 376
Cdd:cd23985   81 AGFQQDVGTKTTIRLINSQLVTTEKHKFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 377 VHPRMEWQLWQRIQDNMGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTELCHYYQRFSDAACTLGAYHPLLYE 456
Cdd:cd23985  161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                        250       260
                 ....*....|....*....|....*.
gi 528514080 457 KNLVKRMNQGSDRDIYTLGRVTLPGF 482
Cdd:cd23985  241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 214-482 3.04e-139

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 401.52  E-value: 3.04e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 214 KLSGPEILCEIKEKVQVTTLTPDMEPFSGFPWgSQLPPRQITSDVGP--FKTCAVVSSAGSLKNSGLGKEIDSHDAVIRF 291
Cdd:cd23986    1 KLSRQELLCELKKRVQVRTLDGKEAPFSALGW-EKYVPKIPLSKLHLrgFRSCAVVTSAGAILNSSLGKEIDSHDAVLRF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 292 NAAPTAGFETDVGSKTTVRLINSQLMASEDHHFLSSSLYSAGILVSWDPSPYSSDLWEWFNKTDYPIFKQYQRYRRLHPQ 371
Cdd:cd23986   80 NSAPTRGYEKDVGNKTTIRIINSQILTNPNHHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPN 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 372 QPFYIVHPRMEWQLWQRIQDNMGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTELCHYYQRFSDAACTLGAYH 451
Cdd:cd23986  160 QPFYILHPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYH 239

                        250       260       270
                 ....*....|....*....|....*....|.
gi 528514080 452 PLLYEKNLVKRMNQGSDRDIYTLGRVTLPGF 482
Cdd:cd23986  240 PLLYEKLLIQRMNKGTEDDLYRKGKVILPGF 270
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 219-482 2.66e-134

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 388.94  E-value: 2.66e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 219 EILCEIKEKVQVTTLTPDMEPFSGFPWGSQLPPRQITSDVGPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAG 298
Cdd:cd23968    3 DLLCRLKKAAPFSTLRKTTSPFKDLLSLRYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 299 FETDVGSKTTVRLINSQLMASEDHHFLSSSLYSAGILVSWDPSPYSSDLWEWFNKTDYPIFKQYQRYRRLHPQQPFYIVH 378
Cdd:cd23968   83 FEKDVGSKTTLRLINSQILSKPEFNFLTDPLYRNVTLLVWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFYLID 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 379 PRMEWQLWQRIQDNMGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTELCHYYQRFSDAACTLGAYHPLLYEKN 458
Cdd:cd23968  163 PRFLWRLWDILQEYTPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDRCHYYDVEKDLACTLGAWHPLAAEKL 242

                        250       260
                 ....*....|....*....|....
gi 528514080 459 LVKRMNQGSDRDIYTLGRVTLPGF 482
Cdd:cd23968  243 LVRHLNVGSDDDIFRKGRATLPGF 266
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 264-463 8.66e-46

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 158.29  E-value: 8.66e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 264 CAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQlmasedhhflSSSLYSAGILVSWDPSPY 343
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSK----------WAGFYLRGPRCGCHPLPL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 344 SSD--LWEWFnkTDYPIFKQYQRYRRLHPQQPFYIVHPRME-WQLWQRIQDNMG--EAIQKNPPSSGLLGTVLMMSLCEV 418
Cdd:cd19952   71 EEEvvLILSR--AAAADFKRLKRRKKRHDNAVLLLTDPAPDlLSYVRKRLEKLGlkSFFGGNAPSSGLLAVLLALQLCDS 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 528514080 419 VHVYEFLPSRRKTEL--CHYYQRFSDAACTlgAYHPLLYEKNLVKRM 463
Cdd:cd19952  149 VDLYGFGVDSGHAPKvpYHYYDLVEAEEGT--AVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 260-465 3.56e-33

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 126.57  E-value: 3.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080  260 PFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLIN--SqLMASEDHHFLSSSLYSAGIL-V 336
Cdd:pfam00777  42 RCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeS-AIDSKYGNLGFSHPRDPFVEfV 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080  337 SwdpSPYSSDLWEW-----FNKTDYPIFKQYQRYRRLH-PQQP--FYIVHPR-MEW--QLWQRiqdnmGEAIQKNPPSSG 405
Cdd:pfam00777 121 L---VPFKGRDLLWlpaflTKGNVSRSLRVLYTLKEVKiPVDPdkVLFLHPDfLRYvaNFWLR-----SHGLKGRRPSTG 192

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528514080  406 LLGTVLMMSLCEVVHVYEFLP--SRRKTELcHYYQRFSDAACTLGAYHPLLYEKNLVKRMNQ 465
Cdd:pfam00777 193 LLMLSLALHLCDEVSLYGFGPflDSRGNSH-HYYDNVLMKKGGFYGVHDMPFEFKLLQKLHK 253
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 259-441 6.75e-30

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 117.75  E-value: 6.75e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 259 GPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKT--------TVRLINSQLMASEDH-HFLSS-S 328
Cdd:cd23963   61 KRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsILKRRYNSLKKNRDRdKFLNRlK 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 329 LYSAGILVswdpspYSSDLWEWFNKtdyPIFKQYQRYR-RLHPQQPFYI--VHPRMEWQLWQRIQDnmgeaiqKNPPSSG 405
Cdd:cd23963  141 EYNGSILW------YPKFSFKSSTN---LLLKAARALKkNGLNLTVVYSnpEHFLAVQKFWKRRGL-------EKRPSTG 204

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 528514080 406 LLGTVLMMSLCEVVHVYEFLP----SRRKTELCHYYQRFS 441
Cdd:cd23963  205 LYLVSLALTFCDEIHLYGFWPfptdPNGRPVPYHYYDDLS 244
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 262-451 4.13e-29

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 114.26  E-value: 4.13e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 262 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLI---NSQLMASeDHHFLSSSLYSAGILVSW 338
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVshsSLPRLLR-NAILLLAGTRAPTVVVFW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 339 DPSPYssdlwewFNKTDYPIFKQYQRYRRLHPQQPFYIVHPRMEWQLWQRIQDNMGeaiqKNPPSSGL-LGT-----VLM 412
Cdd:cd23965   81 GPETK-------MNKDGAGKYNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETG----KSRIKSGTwLSTgwftmLLA 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 528514080 413 MSLCEVVHVYEFLPS------RRKTELCHYYQRFSDAACTLGAYH 451
Cdd:cd23965  150 LDVCDEIKVYGMVPEnycrehPNSKVPYHYYEPGGLKECTYYNYH 194
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 262-463 2.82e-25

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 102.82  E-value: 2.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 262 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLI-------NSQLMASEDHHFlssslysagI 334
Cdd:cd23982    3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypesaqfDPGIENDPDTLL---------V 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 335 LVSWDPSPYssdLW--EWFNKTDYP---IFKQYQRYRRLHPQQpFYIVHPRMEWQLWQRIQDNMGEAIQKNPPSSGLLGT 409
Cdd:cd23982   74 LVPFKPLDF---YWlyEILSNEKRVrkgFWKQPPRIWDANPKQ-IRILNPYYTYVAATKLLQVPGQRKKKQKPTTGLLAI 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 528514080 410 VLMMSLCEVVHVYEF-LP-SRRKTELCHYYQRFSDAAcTLGAYHPLLYEKNLVKRM 463
Cdd:cd23982  150 TLALHLCDEVHIAGFgYPdNGNSNQPIHYYNQITLKS-MANSGHNLNAEAQAIQRL 204
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 262-463 5.44e-24

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 99.29  E-value: 5.44e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 262 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLI--NSQLMASEDHHflSSSLYsagILVswd 339
Cdd:cd23967    3 RRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFypESAFRDPEEYD--SDWLL---VLV--- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 340 psPY-SSDL--------------WEWFNKTDYPIF-KQYQRYRRLHPQQP----FYIVHPRMewqlwqriQDNMGeaiqK 399
Cdd:cd23967   75 --PFkSMDLlwlqavikgkkpngKGGFWKKIATSVpKPPKKIRILNPYILqeaaFDLIGLPM--------NGKQG----K 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528514080 400 NPPSSGLLGTVLMMSLCEVVHV--YEFLPSRRKTELcHYYQRFSDAACTLGAYHPLLYEKNLVKRM 463
Cdd:cd23967  141 NVPTTGIIAIVMALHYCDEVDIagFGYDPSDPNAPL-HYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 250-441 4.43e-21

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 93.11  E-value: 4.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 250 PPRQITSDVGPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTvrlinsqlmasedHHFL---S 326
Cdd:cd23966   66 ENPYRTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTT-------------HHFMypeS 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 327 SSLYSAG---ILVSWDPspysSDLwEWFNK--TDYPIFKQYQRYRR-----------LHPQQpFYIVHPRmeWqlwqriq 390
Cdd:cd23966  133 AVDLDPGvhlVLVPFKV----LDL-QWLISalTTGEITRTYTPVKRfikadkdkvlvINPAF-IKYVHDN--W------- 197

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528514080 391 dnmgeaIQKNP--PSSGLLGTVLMMSLCEVVHVYEFLPSRRKTeLCHYYQRFS 441
Cdd:cd23966  198 ------TEHHGryPSTGFLALIFALHICDEVSVFGFGADSKGN-WHHYWEKNR 243
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 262-463 4.12e-20

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 88.64  E-value: 4.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 262 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQLMASEDHHFLSSSLYSAGILVSWD-- 339
Cdd:cd23983    3 RRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVDfa 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 340 ---------PSPYSSDLWEWFNKTDyPIFKQYQRYRRLHPQqpfyIVH-----------PRMEWQLWqriqdnmgeaiQK 399
Cdd:cd23983   83 wlkamvkkePLSFWSRLFFWKEVAD-SIPLKPSQFRILNPL----IIKetaldilqypePQSRLWGW-----------DK 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528514080 400 NPPSSGLLGTVLMMSLCEVVHVYEF---LpSRRKTELcHYYQRFSDAACTLGAYHPLLYEKNLVKRM 463
Cdd:cd23983  147 NVPTLGVTAVVLATHLCDEVSLAGFgydL-SQPHAPL-HYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 262-422 7.97e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 88.38  E-value: 7.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 262 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQ---LMASEDHHFLSSSlySAGILVSW 338
Cdd:cd23977    2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTsvpLLLRNQGYFFQQS--RDTKYVIW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 339 DPSPYSSDLwewfnkTDYPIFKQYQRYRRLHPQQPFYIVHPRMEWQLWQRIQDNMGEAIQKNPP--SSGLLGTVLMMSLC 416
Cdd:cd23977   80 GPERNMDRD------GGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSflSTGWFTMILALELC 153


                 ....*.
gi 528514080 417 EVVHVY 422
Cdd:cd23977  154 EEILVY 159
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 263-437 2.14e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 88.47  E-value: 2.14e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 263 TCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTT--VRLINSQLMASEDHHFLSSSL-YsagILVSWD 339
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSfyTFFPESLHNSLLKHVPQDKDTkY---LFIPFK 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 340 PSPYSSdLWEWFNKTDYPIFKQ----YQRYRRLHPQ-QPFYIVHP---R-MEWQlWQRIQDNmgeaiqkNPPSSGLLGTV 410
Cdd:cd23964  161 IRDYDY-LDAVLSGKPVPDGCDkgkrPPPLFGPKLNaTNVRLLHPdfiRyLFNR-WLNSSTS-------YRPTTGALMLL 231

                        170       180
                 ....*....|....*....|....*..
gi 528514080 411 LMMSLCEVVHVYEFLPSRRKTElcHYY 437
Cdd:cd23964  232 TALHTCDQVSVYGFGYDPRFSL--HYY 256
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 261-437 9.13e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 86.31  E-value: 9.13e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 261 FKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQLMASEDHHFLSSSLYSA-------- 332
Cdd:cd23969   64 FRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPHAYGDLVNATDKEKfverlrql 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 333 --GILvsWDP---SPYSSDLWEWFNKTdypIFKQYQRYRRLHPQqpfyivhPRMEwQLWQRIQDNMGEAIQKnpPSSGLL 407
Cdd:cd23969  144 gdSIL--WIPafvSKGGEEHVQWTNEI---ILKHKLNVKTAYPP-------LRLN-HAIRGYWLTTKFRIKR--PSTGLL 208

                        170       180       190
                 ....*....|....*....|....*....|....
gi 528514080 408 GTVLMMSLCEVVHVYEFLP---SRRKTEL-CHYY 437
Cdd:cd23969  209 MYTLATRFCDEIHLYGFYPfseDGNGRAVkYHYY 242
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 260-463 4.25e-18

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 82.49  E-value: 4.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 260 PFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQLMASEDHHFLSSSLYsagILVSWD 339
Cdd:cd23984    1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTV---VLIPFK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 340 PspysSDL---WE------------WFNKTDYPIFKQYQrYRRLHpqqPFYIVHPRMEWqlwqrIQDNMGEAIQKNP--P 402
Cdd:cd23984   78 P----HDLrwlLDllmgkkvsakgfWKKPALNLIYKPNQ-IRILN---PFILRIAAYEL-----LHFPKRFPKEKKPkhP 144

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528514080 403 SSGLLGTVLMMSLCEVVHV----YEFlpSRRKTELcHYYQRFSDAACTLGAYHPLLYEKNLVKRM 463
Cdd:cd23984  145 TTGIIAITLALHICNEVHIagfkYDF--SNLNSTL-HYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 262-424 2.62e-17

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 82.24  E-value: 2.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 262 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTvrlinsqlmasedHHFL-SSSLYSAGILVSWDP 340
Cdd:cd23980   82 RRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTT-------------HHFVyPESFRELAQNVSMIL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 341 SPYSSDLWEW---------FNKTDYPIfkqyqrYRRLHPQQP-FYIVHPRMEWQLWQRIQDNMGEAiqknpPSSGLLGTV 410
Cdd:cd23980  149 VPFKTLDLEWvisatttgtISHTYVPV------PRKIKVKKEkILIYHPAFIKYVFDRWLQGHGRY-----PSTGILSVI 217

                        170
                 ....*....|....
gi 528514080 411 LMMSLCEVVHVYEF 424
Cdd:cd23980  218 FSLHVCDEVDLYGF 231
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 264-462 2.68e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 81.05  E-value: 2.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 264 CAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLIN----SQLMASEDhHFLssSLYSAGILVSWD 339
Cdd:cd23978    4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAhssvYRVLRRPQ-EFL--NRTPETTLIFWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 340 PspyssdlwewFNKTDYP----IFKQYQRYRRLHPQQPFYIVHPRMEWQLWQRIQDNMGEAIQKNPP--SSGLLGTVLMM 413
Cdd:cd23978   81 P----------PNKMQKDgksnLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSwlSTGWFTMVIAV 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528514080 414 SLCEVVHVYEFLP-------SRRKTELCHYYQRFSDAACTL---------GAYHPLLYEKNLVKR 462
Cdd:cd23978  151 ELCDNVHVYGMVPpnycskrPTPKKMPYHYYEPKGPDECVTyiqnehgrrGNHHRFITEKRVFAR 215
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 261-426 9.02e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 77.69  E-value: 9.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 261 FKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQLMA--------SEDHHFLSSSLYSA 332
Cdd:cd23988   64 FKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQrafggfrnESDREKFVHRLSML 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 333 GILVSWDPS---PYSSDLWEWFNKTdypIFKQYQRYRRLHPQqpFYIVHPRMEWQLWQRIQdnmgeaIQKnpPSSGLLGT 409
Cdd:cd23988  144 NDSVLWIPAfmvKGGEKHVEWVNAL---ILKNKLKVRTAYPS--LRLIHAVRGYWLTNKVN------IKR--PSTGLLMY 210

                        170
                 ....*....|....*..
gi 528514080 410 VLMMSLCEVVHVYEFLP 426
Cdd:cd23988  211 TLATRFCDEIHLYGFWP 227
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 223-426 1.51e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 76.53  E-value: 1.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 223 EIKEKVQVTTLTPDMEPFSgFPWGSqlpprqitsdvGPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAgFETD 302
Cdd:cd23971   38 ERKKTITVNEKLFSMLPKE-SPFSN-----------KPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKD 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 303 VGSKTTVRLIN-SQLMasEDHHFLssslysagilvSWDPSPYSSDLWEWFNKTDY-PIFkQYQR-----YRRLH------ 369
Cdd:cd23971  105 VGSKTNLVTANpSILR--EKFHNL-----------KKRRRPFVERMKVYGNALLLlPAF-SYTSntepsLRALYtledfg 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528514080 370 -PQQPFYIvHPRMEWQL---WQriqdnmGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLP 426
Cdd:cd23971  171 sPQKVLFF-NPEYLRNLsryWK------SKGLKARRLSTGLMLVSAALELCENVHLYGFWP 224
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 223-437 1.83e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 76.33  E-value: 1.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 223 EIKEKVQVTTLTPDMEPFSGFPwgsqlpprqitsdvgpFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAG-FET 301
Cdd:cd23991   42 KILITENIFRMFPKSQPFRGYP----------------YKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISK 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 302 DVGSKTTVRLINSQLMA---SEDHH----FLSS-SLYSAGILVSwdPS-PYSSDLWEWFnKTDYPI--FKQYQRYRRLHP 370
Cdd:cd23991  106 DVGSKTNLVTANPSIISikyAKLNErrkpFLETvSVYGDAFLLL--PAfSYRSNTALSF-KVYYTLedFKAKQKVIFFHP 182

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528514080 371 QqpfYIVHPRMEWQlwqriqdnmGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTE----LCHYY 437
Cdd:cd23991  183 I---YLKHLAQFWR---------SKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEgkpiSHHYY 241
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 261-463 4.48e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 75.51  E-value: 4.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 261 FKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLIN--------SQLMASEDHHFLSSSLYSA 332
Cdd:cd23970   68 YNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNpsilekyyNNLLTIQDRNNFFLSLKKL 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 333 GILVSWDPS---PYSSD--------LWEWFNKTD----YP--IFKQYQRYRRLHPQQPfyivhprmewqlwQRIqdnmge 395
Cdd:cd23970  148 DGAILWIPAfffHTSATvtrtlvdfFVEHRGQLKvqlaWPgnIMQHVNRYWKTKHLSP-------------KRL------ 208

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528514080 396 aiqknppSSGLLGTVLMMSLCEVVHVYEFLP---SRRKTELC-HYYQRFsDAACTLG--AYHPLLYEKNLVKRM 463
Cdd:cd23970  209 -------STGILMYTLASAICEEIHLYGFWPfgfDPTGTPLPyHYYDKK-GTKFTTKwqESHQLPAEFVLLYKM 274
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 262-465 4.87e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 74.52  E-value: 4.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 262 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLI---NSQLMASEDHHFLSSSlySAGILVSW 338
Cdd:cd23976   16 KSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIahsSIQRILRNRNELLNVS--QGTVFIFW 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 339 DPSPYSsdlwewfnKTDYP--IFKQYQRYRRLHPQQPFYIVHPRMEWQLWQRIQDNMGE--AIQKNPPSSGLLGTVLMMS 414
Cdd:cd23976   94 GPSNYM--------RRDGKglVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKdrKISNTWLSTGWFTMIIALE 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528514080 415 LCEVVHVY-----EFLPSRRKTEL-CHYYQRFSDAACTL---------GAYHPLLYEKNLVKRMNQ 465
Cdd:cd23976  166 LCDRINVYgmvppDFCRDPNHPSVpYHYYEPSGPDECTMyishergrkGSHHRFITEKRVFANWAR 231
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 261-437 7.55e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 74.59  E-value: 7.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 261 FKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQLM--ASED-------HHFLsSSLYS 331
Cdd:cd23987   64 FKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVqrAFEDlvnetwkEKFL-QRLQS 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 332 AGILVSWDPSPYS---SDLWEWFNKTdypIFKQYQRYRRLHPQqpFYIVHPRMEWQLWQRIQdnmgeaIQKnpPSSGLLG 408
Cdd:cd23987  143 LNGSILWIPAFMAkggEERVEWVNDL---ILKHHINVRTAYPS--LRLLHAVRGYWLTNKVH------IKR--PTTGLLM 209

                        170       180       190
                 ....*....|....*....|....*....|...
gi 528514080 409 TVLMMSLCEVVHVYEFLPSRR----KTELCHYY 437
Cdd:cd23987  210 YTLATRFCNRIHLYGFWPFPRdqnqNPVKYHYY 242
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 263-463 3.78e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 73.25  E-value: 3.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 263 TCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSqlmasedhHFLSSSLYSAG--------- 333
Cdd:cd23973   85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTA--------HSITSSLMILQkrgfknipq 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 334 ------ILVSWDPSPYssdlwEWF-----NKT--DYPIFKQYQRYR---RLHPQQpFYIVHP---RMEWQLWQRIQDNMG 394
Cdd:cd23973  157 dkdikyILFPEGPRDY-----QWLeallkNKTipSGAYYGRRPRSYfsgDFTEDK-YLVLHPdflRYVKNRFLRSKTLKG 230

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528514080 395 EAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTELCHYYQRfSDAACTLGAYHPLLYEKNLVKRM 463
Cdd:cd23973  231 KYWAIYRPTTGAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDK-KKTKLVFYINHDFRLEKKLWKRL 298
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 264-325 9.76e-13

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 68.36  E-value: 9.76e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528514080 264 CAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTvrlinsqlmasedHHFL 325
Cdd:cd23979   83 CAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTT-------------HHFM 131
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 261-424 2.76e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 67.17  E-value: 2.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 261 FKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAP-TAGFETDVGSKTTVRLINSQLMASEDHHF---------LSSSLY 330
Cdd:cd23990   64 FKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTINPSIITERFHKLekwrrpfyeVLQVYE 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 331 SAGILVswdPSPYSSdlwewfNKTDYPIFKQYQrYRRLHPQQPFYIVHPRMEWQLwQRIQDNMGeaIQKNPPSSGLLGTV 410
Cdd:cd23990  144 NASVVL---PAFYNT------RNTDVSIRVKYV-LDDFESQQAVYYFHPQYLLNV-SRFWLRQG--VRAKRISSGLMLVT 210

                        170
                 ....*....|....
gi 528514080 411 LMMSLCEVVHVYEF 424
Cdd:cd23990  211 AALELCEEVHLYGF 224
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 262-311 2.98e-12

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 65.71  E-value: 2.98e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 528514080 262 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRL 311
Cdd:cd23981    3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRI 52
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 231-437 6.49e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 66.01  E-value: 6.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 231 TTLTPDMEPFSGFPwgsQLPPRQItsdvgPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAP-TAGFETDVGSKTTV 309
Cdd:cd23989   41 HSHTVDNETYSLFP---QDTPLQL-----PLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 310 RLINSQLMASEDHHFLSSSLYSAGILVSWDPSPYSSDLWEWFNKTDyPIFKQYQRYRRLHPQQPFYIVHP---RMEWQLW 386
Cdd:cd23989  113 VTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTD-PSLRVYYTLADVGANQTVLFANPnflRNVGKFW 191

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 528514080 387 QriqdnmGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSR----RKTELCHYY 437
Cdd:cd23989  192 K------SKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSvdldERTISHHYY 240
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 264-308 1.98e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 64.77  E-value: 1.98e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 528514080 264 CAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTT 308
Cdd:cd23974   87 CAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTS 131
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 241-464 3.21e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 64.46  E-value: 3.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 241 SGFPWGSQLPPRQITsdvgpfktCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKT-----TVRLINSQ 315
Cdd:cd23972   70 AKLFFPRDTPGKCIR--------CAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTsfygfTVNTMKNS 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 316 LMASEDHHFLSSS------------------LYSAGILVSwdPSPYSSDlwewfnKTDypifkQYQRYRRLHPQ-QPFYI 376
Cdd:cd23972  142 LISYWNLGFTRTPqgqdlqyifipsdirdyvMLRSAILGV--PVPEGLD------KGD-----RPHKYFGPEASaKKFKL 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 377 VHPRMEWQLWQR------IQDNMGEAIQknpPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTELCHYYQRfSDAACTLGAY 450
Cdd:cd23972  209 LHPDFISYLTDRflksklLNTHYGHLYM---PSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYYER-KKKPLVFYAN 284

                        250
                 ....*....|....
gi 528514080 451 HPLLYEKNLVKRMN 464
Cdd:cd23972  285 HDMLLEAALWRRLH 298
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 264-422 1.35e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 61.10  E-value: 1.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 264 CAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQ---LMASEDHHFLSSSlySAGILVSWDP 340
Cdd:cd23975    4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTsvpLLLKNPDYFFKET--NETIYVIWGP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528514080 341 spyssdLWEWFNKTDYPIFKQYQRYRRLHPQQPFYI-VHPRMEWQLWQRIQDNMGEAIQKNP-PSSGLLGTVLMMSLCEV 418
Cdd:cd23975   82 ------FRNMRKDGKGIVYNMLKKAVESYPQAKIYVtTEKRMSYCDTVFKKETGKDRVQSGSyLSTGWFTLILAMDACYG 155


                 ....
gi 528514080 419 VHVY 422
Cdd:cd23975  156 IHVY 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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