NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|528512051|ref|XP_005160875|]
View 

N-acetyltransferase ESCO2 isoform X1 [Danio rerio]

Protein Classification

ESCO family N-acetyltransferase( domain architecture ID 13315065)

ESCO family N-acetyltransferase contains a C2H2 zinc finger, is required for the establishment of sister chromatid cohesion, and may acetylate components of the cohesin complex; contains an N-terminal region with similarity to a partial 104 kDa microneme/rhoptry antigen domain; similar to Danio rerio N-acetyltransferase ESCO2

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_13 pfam13880
ESCO1/2 acetyl-transferase;
536-604 1.58e-36

ESCO1/2 acetyl-transferase;


:

Pssm-ID: 464015  Cd Length: 69  Bit Score: 130.68  E-value: 1.58e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528512051  536 EKALCGVSRIWVFSLMRRKSVATRLLDTARNTFMYGSHLTKEEIAFSDPTPQGKLFATKYCQTPTFLVY 604
Cdd:pfam13880   1 VPAKCGISRIWVSPSHRRKGIATRLLDAARSNFIYGYILEKDEIAFSQPTESGKAFARKYFGTDDFLVY 69
zf-C2H2_3 pfam13878
zinc-finger of acetyl-transferase ESCO;
378-417 3.14e-16

zinc-finger of acetyl-transferase ESCO;


:

Pssm-ID: 464013  Cd Length: 40  Bit Score: 72.27  E-value: 3.14e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 528512051  378 QLIIDAGQKQFGATTCASCGMLYSTDSPEDNFQHTQFHQR 417
Cdd:pfam13878   1 QLILDLGQKSFGATQCKECGMVYNPGSPEDEKLHKKYHAR 40
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 3-305 5.07e-05

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.61  E-value: 5.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528512051   3 SRKRKHGSPDAESNPSKKQITSLRSSPRRTTRQ----KENIPISLNSPQKIPSTPKKTQRAFLLESPPKRVSPRKAVLGA 78
Cdd:PTZ00449 528 EGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKpgpaKEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRPT 607

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528512051  79 GTFYSKQKPLYLTPLERKVLKEAKSPPS-VTNKEPSRPPLTAANQVVKPAKKVQKKPRASAPQSNLKGYFTAKPKATKSS 157
Cdd:PTZ00449 608 RPKSPKLPELLDIPKSPKRPESPKSPKRpPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSK 687

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528512051 158 SDKQTDQVLKSTMAPISFSSMKSKGKPKLVVGAAffnTGKKPTSmykKSAQNTKPK-PTYEKPSirkpvrEKELVTAPGQ 236
Cdd:PTZ00449 688 ETKTTVVLDESFESILKETLPETPGTPFTTPRPL---PPKLPRD---EEFPFEPIGdPDAEQPD------DIEFFTPPEE 755

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528512051 237 RSpvrraVFLKKQPEVEVSHD-KRESTQAPmspqvlaDVHGITKELRVVLRRSVSPETGSQDAPSEADSV 305
Cdd:PTZ00449 756 ER-----TFFHETPADTPLPDiLAEEFKEE-------DIHAETGEPDEAMKRPDSPSEHEDKPPGDHPSL 813
 
Name Accession Description Interval E-value
Acetyltransf_13 pfam13880
ESCO1/2 acetyl-transferase;
536-604 1.58e-36

ESCO1/2 acetyl-transferase;


Pssm-ID: 464015  Cd Length: 69  Bit Score: 130.68  E-value: 1.58e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528512051  536 EKALCGVSRIWVFSLMRRKSVATRLLDTARNTFMYGSHLTKEEIAFSDPTPQGKLFATKYCQTPTFLVY 604
Cdd:pfam13880   1 VPAKCGISRIWVSPSHRRKGIATRLLDAARSNFIYGYILEKDEIAFSQPTESGKAFARKYFGTDDFLVY 69
zf-C2H2_3 pfam13878
zinc-finger of acetyl-transferase ESCO;
378-417 3.14e-16

zinc-finger of acetyl-transferase ESCO;


Pssm-ID: 464013  Cd Length: 40  Bit Score: 72.27  E-value: 3.14e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 528512051  378 QLIIDAGQKQFGATTCASCGMLYSTDSPEDNFQHTQFHQR 417
Cdd:pfam13878   1 QLILDLGQKSFGATQCKECGMVYNPGSPEDEKLHKKYHAR 40
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 3-305 5.07e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.61  E-value: 5.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528512051   3 SRKRKHGSPDAESNPSKKQITSLRSSPRRTTRQ----KENIPISLNSPQKIPSTPKKTQRAFLLESPPKRVSPRKAVLGA 78
Cdd:PTZ00449 528 EGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKpgpaKEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRPT 607

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528512051  79 GTFYSKQKPLYLTPLERKVLKEAKSPPS-VTNKEPSRPPLTAANQVVKPAKKVQKKPRASAPQSNLKGYFTAKPKATKSS 157
Cdd:PTZ00449 608 RPKSPKLPELLDIPKSPKRPESPKSPKRpPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSK 687

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528512051 158 SDKQTDQVLKSTMAPISFSSMKSKGKPKLVVGAAffnTGKKPTSmykKSAQNTKPK-PTYEKPSirkpvrEKELVTAPGQ 236
Cdd:PTZ00449 688 ETKTTVVLDESFESILKETLPETPGTPFTTPRPL---PPKLPRD---EEFPFEPIGdPDAEQPD------DIEFFTPPEE 755

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528512051 237 RSpvrraVFLKKQPEVEVSHD-KRESTQAPmspqvlaDVHGITKELRVVLRRSVSPETGSQDAPSEADSV 305
Cdd:PTZ00449 756 ER-----TFFHETPADTPLPDiLAEEFKEE-------DIHAETGEPDEAMKRPDSPSEHEDKPPGDHPSL 813
 
Name Accession Description Interval E-value
Acetyltransf_13 pfam13880
ESCO1/2 acetyl-transferase;
536-604 1.58e-36

ESCO1/2 acetyl-transferase;


Pssm-ID: 464015  Cd Length: 69  Bit Score: 130.68  E-value: 1.58e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528512051  536 EKALCGVSRIWVFSLMRRKSVATRLLDTARNTFMYGSHLTKEEIAFSDPTPQGKLFATKYCQTPTFLVY 604
Cdd:pfam13880   1 VPAKCGISRIWVSPSHRRKGIATRLLDAARSNFIYGYILEKDEIAFSQPTESGKAFARKYFGTDDFLVY 69
zf-C2H2_3 pfam13878
zinc-finger of acetyl-transferase ESCO;
378-417 3.14e-16

zinc-finger of acetyl-transferase ESCO;


Pssm-ID: 464013  Cd Length: 40  Bit Score: 72.27  E-value: 3.14e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 528512051  378 QLIIDAGQKQFGATTCASCGMLYSTDSPEDNFQHTQFHQR 417
Cdd:pfam13878   1 QLILDLGQKSFGATQCKECGMVYNPGSPEDEKLHKKYHAR 40
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 3-305 5.07e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.61  E-value: 5.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528512051   3 SRKRKHGSPDAESNPSKKQITSLRSSPRRTTRQ----KENIPISLNSPQKIPSTPKKTQRAFLLESPPKRVSPRKAVLGA 78
Cdd:PTZ00449 528 EGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKpgpaKEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRPT 607

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528512051  79 GTFYSKQKPLYLTPLERKVLKEAKSPPS-VTNKEPSRPPLTAANQVVKPAKKVQKKPRASAPQSNLKGYFTAKPKATKSS 157
Cdd:PTZ00449 608 RPKSPKLPELLDIPKSPKRPESPKSPKRpPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSK 687

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528512051 158 SDKQTDQVLKSTMAPISFSSMKSKGKPKLVVGAAffnTGKKPTSmykKSAQNTKPK-PTYEKPSirkpvrEKELVTAPGQ 236
Cdd:PTZ00449 688 ETKTTVVLDESFESILKETLPETPGTPFTTPRPL---PPKLPRD---EEFPFEPIGdPDAEQPD------DIEFFTPPEE 755

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528512051 237 RSpvrraVFLKKQPEVEVSHD-KRESTQAPmspqvlaDVHGITKELRVVLRRSVSPETGSQDAPSEADSV 305
Cdd:PTZ00449 756 ER-----TFFHETPADTPLPDiLAEEFKEE-------DIHAETGEPDEAMKRPDSPSEHEDKPPGDHPSL 813
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH