NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|528468128|ref|XP_005159933|]
View 

coronin-2A isoform X2 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-526 3.02e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 282.94  E-value: 3.02e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128  15 SKYRHVFGKPATKENCYDGVPITRSVHD-NQLCAANPRFIAVITECAGGGSFLvlpvHHT--GKVDPHHPKVSGHRGNVL 91
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVL----KHTdyGKLASNPPILLGQEGPII 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128  92 DIKWNHFNDFCIASCSEDATVKIWEIPEHGVLKTITVPWKELQGHSRRVGLIEWHPTANNIIFSTGYDYQVMVWklDVPE 171
Cdd:PTZ00421  80 DVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVW--DVER 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 172 QVIKNpvrSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVIDPRTGTILQETNC-KSHKASKVLFLGNLKMLLSTGNSRW 250
Cdd:PTZ00421 158 GKAVE---VIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAhASAKSQRCLWAKRKDLIITLGCSKS 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 251 NHRQIALWDQEDLSQPSYSEDLDGSSGVLFPFYDPDTHMLYIAGKGDGNIRYYEISPEKpyVHYLTEYRSHLPQKGMGVM 330
Cdd:PTZ00421 235 QQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMM 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 331 PKRGLDVCSCEIFRFYKLvTIKSLIePLSMIVPRRS--ESYQEDIYPMTAGNKPAMTANEWISGLDKGPVMMSLRPGSKV 408
Cdd:PTZ00421 313 PKWSLDTRKCEIARFYAL-TYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDG 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 409 DTYVELGLKKSPMESTEMHNSRSQPGLSQLIQrlETKDGNGRKESHPTLLLPSTEENGSSASHVSNGQldsphcsppkte 488
Cdd:PTZ00421 391 TSPELMGASALSPSGKPRHSGVSVPASTSAMT--HSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQ------------ 456

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 528468128 489 nELRQMFYKQQEEIRKMRELLNQKDVRIKQLELEIKNV 526
Cdd:PTZ00421 457 -ALSEKLRTQHEEIKRCREALQKKESIVMETLEKIQSI 493
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 15-526 3.02e-89

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 282.94  E-value: 3.02e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128  15 SKYRHVFGKPATKENCYDGVPITRSVHD-NQLCAANPRFIAVITECAGGGSFLvlpvHHT--GKVDPHHPKVSGHRGNVL 91
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVL----KHTdyGKLASNPPILLGQEGPII 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128  92 DIKWNHFNDFCIASCSEDATVKIWEIPEHGVLKTITVPWKELQGHSRRVGLIEWHPTANNIIFSTGYDYQVMVWklDVPE 171
Cdd:PTZ00421  80 DVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVW--DVER 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 172 QVIKNpvrSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVIDPRTGTILQETNC-KSHKASKVLFLGNLKMLLSTGNSRW 250
Cdd:PTZ00421 158 GKAVE---VIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAhASAKSQRCLWAKRKDLIITLGCSKS 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 251 NHRQIALWDQEDLSQPSYSEDLDGSSGVLFPFYDPDTHMLYIAGKGDGNIRYYEISPEKpyVHYLTEYRSHLPQKGMGVM 330
Cdd:PTZ00421 235 QQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMM 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 331 PKRGLDVCSCEIFRFYKLvTIKSLIePLSMIVPRRS--ESYQEDIYPMTAGNKPAMTANEWISGLDKGPVMMSLRPGSKV 408
Cdd:PTZ00421 313 PKWSLDTRKCEIARFYAL-TYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDG 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 409 DTYVELGLKKSPMESTEMHNSRSQPGLSQLIQrlETKDGNGRKESHPTLLLPSTEENGSSASHVSNGQldsphcsppkte 488
Cdd:PTZ00421 391 TSPELMGASALSPSGKPRHSGVSVPASTSAMT--HSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQ------------ 456

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 528468128 489 nELRQMFYKQQEEIRKMRELLNQKDVRIKQLELEIKNV 526
Cdd:PTZ00421 457 -ALSEKLRTQHEEIKRCREALQKKESIVMETLEKIQSI 493
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 12-75 5.71e-34

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 122.61  E-value: 5.71e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528468128   12 YRSSKYRHVFGKPATKENCYDGVPITRSVHDNQLCAANPRFIAVITECAGGGSFLVLPVHHTGK 75
Cdd:pfam08953   3 VRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 COG2319
WD40 repeat [General function prediction only];
84-321 3.47e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.75  E-value: 3.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128  84 SGHRGNVLDIKWNHFNDFcIASCSEDATVKIWEIPEHGVLKTitvpwkeLQGHSRRVGLIEWHPTaNNIIFSTGYDYQVM 163
Cdd:COG2319  159 TGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRT-------LTGHTGAVRSVAFSPD-GKLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 164 VWKLDVPEqviknPVRSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVIDPRTGTILQETNCKSHKASKVLFLGNLKMLL 243
Cdd:COG2319  230 LWDLATGK-----LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLA 304

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528468128 244 STGNSrwnhRQIALWDQEDLSQP-SYSEDLDGSSGVLFpfyDPDTHMLYIAGkGDGNIRYYEISPEKPyvhyLTEYRSH 321
Cdd:COG2319  305 SGSDD----GTVRLWDLATGKLLrTLTGHTGAVRSVAF---SPDGKTLASGS-DDGTVRLWDLATGEL----LRTLTGH 371
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-321 9.17e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 9.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128  83 VSGHRGNVLDIKWNHFNDFcIASCSEDATVKIWEIPEHGVLKTitvpwkeLQGHSRRVGLIEWHPTANNIiFSTGYDYQV 162
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRT-------LKGHTGPVRDVAASADGTYL-ASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 163 MVWKLDVPEqviknPVRSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVIDPRTGTILQETNCKSHKASKVLFLGNlKML 242
Cdd:cd00200   76 RLWDLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTF 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 243 LSTGnsrWNHRQIALWdqeDLSQPSYSEDLDG-SSGVLFPFYDPDTHMLYIAGkGDGNIRYYEISPEKPyvhyLTEYRSH 321
Cdd:cd00200  150 VASS---SQDGTIKLW---DLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSS-SDGTIKLWDLSTGKC----LGTLRGH 218
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-213 3.23e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.23e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528468128   175 KNPVRSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVID 213
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 15-526 3.02e-89

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 282.94  E-value: 3.02e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128  15 SKYRHVFGKPATKENCYDGVPITRSVHD-NQLCAANPRFIAVITECAGGGSFLvlpvHHT--GKVDPHHPKVSGHRGNVL 91
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVL----KHTdyGKLASNPPILLGQEGPII 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128  92 DIKWNHFNDFCIASCSEDATVKIWEIPEHGVLKTITVPWKELQGHSRRVGLIEWHPTANNIIFSTGYDYQVMVWklDVPE 171
Cdd:PTZ00421  80 DVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVW--DVER 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 172 QVIKNpvrSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVIDPRTGTILQETNC-KSHKASKVLFLGNLKMLLSTGNSRW 250
Cdd:PTZ00421 158 GKAVE---VIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAhASAKSQRCLWAKRKDLIITLGCSKS 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 251 NHRQIALWDQEDLSQPSYSEDLDGSSGVLFPFYDPDTHMLYIAGKGDGNIRYYEISPEKpyVHYLTEYRSHLPQKGMGVM 330
Cdd:PTZ00421 235 QQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMM 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 331 PKRGLDVCSCEIFRFYKLvTIKSLIePLSMIVPRRS--ESYQEDIYPMTAGNKPAMTANEWISGLDKGPVMMSLRPGSKV 408
Cdd:PTZ00421 313 PKWSLDTRKCEIARFYAL-TYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDG 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 409 DTYVELGLKKSPMESTEMHNSRSQPGLSQLIQrlETKDGNGRKESHPTLLLPSTEENGSSASHVSNGQldsphcsppkte 488
Cdd:PTZ00421 391 TSPELMGASALSPSGKPRHSGVSVPASTSAMT--HSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQ------------ 456

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 528468128 489 nELRQMFYKQQEEIRKMRELLNQKDVRIKQLELEIKNV 526
Cdd:PTZ00421 457 -ALSEKLRTQHEEIKRCREALQKKESIVMETLEKIQSI 493
PTZ00420 PTZ00420
coronin; Provisional
 24-453 1.10e-61

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 212.50  E-value: 1.10e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128  24 PATKENCYDGVPITRSVHDNQLCAANPRFIAVITECAGGGSFLVLPVHHTGKvDPHHPKVSGHRGNVLDIKWNHFNDFCI 103
Cdd:PTZ00420  12 PDPSNNLFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR-KPPVIKLKGHTSSILDLQFNPCFSEIL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 104 ASCSEDATVKIWEIP-EHGVLKTITVPWKELQGHSRRVGLIEWHPTANNIIFSTGYDYQVMVWKldvpeqvIKNPVRSIS 182
Cdd:PTZ00420  91 ASGSEDLTIRVWEIPhNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWD-------IENEKRAFQ 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 183 VHSDVVLS-MSFNTDGSKLATSCKDKKIRVIDPRTGTILQETNCKSH-KASKVLFL----GNLKMLLSTGNSRWNHRQIA 256
Cdd:PTZ00420 164 INMPKKLSsLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGgKNTKNIWIdglgGDDNYILSTGFSKNNMREMK 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 257 LWDQEDLSQPSYSEDLDGSSGVLFPFYDPDTHMLYIAGKGDGNIRYYEISpeKPYVHYLTEYRSHLPQKGMGVMPKRGLD 336
Cdd:PTZ00420 244 LWDLKNTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHS--LGSIRKVNEYKSCSPFRSFGFLPKQICD 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 337 VCSCEIFRFYKLVTiKSLIEPLSMIVPRRSES-YQEDIYPMTAGNKPAMTANEWISGLDKGPVMMSLRPGSKVDTYVELG 415
Cdd:PTZ00420 322 VYKCEIGRVYKNEN-NSSIRPISFYVPRKNPTkFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKDLTEDDLRITKK 400

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 528468128 416 LKKSPMEST-----EMHNSRSQPGLSQLIQRL------ETKDGNGRKES 453
Cdd:PTZ00420 401 YKFVPQSFNsiiigENYTSKRTSIIRQFTKKFtffkkgEHNDGFSSVDS 449
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 12-75 5.71e-34

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 122.61  E-value: 5.71e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528468128   12 YRSSKYRHVFGKPATKENCYDGVPITRSVHDNQLCAANPRFIAVITECAGGGSFLVLPVHHTGK 75
Cdd:pfam08953   3 VRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 COG2319
WD40 repeat [General function prediction only];
84-321 3.47e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.75  E-value: 3.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128  84 SGHRGNVLDIKWNHFNDFcIASCSEDATVKIWEIPEHGVLKTitvpwkeLQGHSRRVGLIEWHPTaNNIIFSTGYDYQVM 163
Cdd:COG2319  159 TGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRT-------LTGHTGAVRSVAFSPD-GKLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 164 VWKLDVPEqviknPVRSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVIDPRTGTILQETNCKSHKASKVLFLGNLKMLL 243
Cdd:COG2319  230 LWDLATGK-----LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLA 304

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528468128 244 STGNSrwnhRQIALWDQEDLSQP-SYSEDLDGSSGVLFpfyDPDTHMLYIAGkGDGNIRYYEISPEKPyvhyLTEYRSH 321
Cdd:COG2319  305 SGSDD----GTVRLWDLATGKLLrTLTGHTGAVRSVAF---SPDGKTLASGS-DDGTVRLWDLATGEL----LRTLTGH 371
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-321 9.17e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 9.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128  83 VSGHRGNVLDIKWNHFNDFcIASCSEDATVKIWEIPEHGVLKTitvpwkeLQGHSRRVGLIEWHPTANNIiFSTGYDYQV 162
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRT-------LKGHTGPVRDVAASADGTYL-ASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 163 MVWKLDVPEqviknPVRSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVIDPRTGTILQETNCKSHKASKVLFLGNlKML 242
Cdd:cd00200   76 RLWDLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTF 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 243 LSTGnsrWNHRQIALWdqeDLSQPSYSEDLDG-SSGVLFPFYDPDTHMLYIAGkGDGNIRYYEISPEKPyvhyLTEYRSH 321
Cdd:cd00200  150 VASS---SQDGTIKLW---DLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSS-SDGTIKLWDLSTGKC----LGTLRGH 218
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 85-304 4.61e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 4.61e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128  85 GHRGNVLDIKWNHfNDFCIASCSEDATVKIWEIPEHGVLKTitvpwkeLQGHSRRVGLIEWHPTaNNIIFSTGYDYQVMV 164
Cdd:cd00200   91 GHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTT-------LRGHTDWVNSVAFSPD-GTFVASSSQDGTIKL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 165 WKLDvpeqvIKNPVRSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVIDPRTGTILQEtnCKSHKAS--KVLFLGNLKML 242
Cdd:cd00200  162 WDLR-----TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT--LRGHENGvnSVAFSPDGYLL 234

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528468128 243 LSTgnSRWNHrqIALWdqeDLSQPSYSEDLDG-SSGVLFPFYDPDTHMLYIAGKgDGNIRYYE 304
Cdd:cd00200  235 ASG--SEDGT--IRVW---DLRTGECVQTLSGhTNSVTSLAWSPDGKRLASGSA-DGTIRIWD 289
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 355-397 1.05e-18

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 79.48  E-value: 1.05e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 528468128  355 IEPLSMIVPRRS-ESYQEDIYPMTAGNKPAMTANEWISGLDKGP 397
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 COG2319
WD40 repeat [General function prediction only];
84-259 6.69e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 6.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128  84 SGHRGNVLDIKWNHfNDFCIASCSEDATVKIWEIPEHGVLKTitvpwkeLQGHSRRVGLIEWHPTaNNIIFSTGYDYQVM 163
Cdd:COG2319  243 TGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRT-------LTGHSGGVNSVAFSPD-GKLLASGSDDGTVR 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 164 VWKLDVPEqviknPVRSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVIDPRTGTILQETncKSHKAS--KVLFLGNLKM 241
Cdd:COG2319  314 LWDLATGK-----LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL--TGHTGAvtSVAFSPDGRT 386

                        170
                 ....*....|....*...
gi 528468128 242 LLSTGnsrwNHRQIALWD 259
Cdd:COG2319  387 LASGS----ADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
84-216 1.04e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.18  E-value: 1.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128  84 SGHRGNVLDIKWNHFNDFcIASCSEDATVKIWEIPEHGVLKTitvpwkeLQGHSRRVGLIEWHPTaNNIIFSTGYDYQVM 163
Cdd:COG2319  285 TGHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRT-------LTGHTGAVRSVAFSPD-GKTLASGSDDGTVR 355

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528468128 164 VWKLDVPEQViknpvRSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVIDPRT 216
Cdd:COG2319  356 LWDLATGELL-----RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
103-301 2.89e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 2.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 103 IASCSEDATVKIWEIPEHGVLKTitvpwkeLQGHSRRVGLIEWHPTaNNIIFSTGYDYQVMVWKLDVPEqviknPVRSIS 182
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRT-------LTGHTGAVRSVAFSPD-GKTLASGSADGTVRLWDLATGK-----LLRTLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 183 VHSDVVLSMSFNTDGSKLATSCKDKKIRVIDPRTGTILQETNCKSHKASKVLFLGNLKMLLSTGNSrwnhRQIALWdqeD 262
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAD----GTVRLW---D 232

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 528468128 263 LSQPSYSEDLDG-SSGVLFPFYDPDTHMLYIAGkGDGNIR 301
Cdd:COG2319  233 LATGKLLRTLTGhSGSVRSVAFSPDGRLLASGS-ADGTVR 271
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 131-310 1.53e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 1.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 131 KELQGHSRRVGLIEWHPTaNNIIFSTGYDYQVMVWKLDVPEqviknPVRSISVHSDVVLSMSFNTDGSKLATSCKDKKIR 210
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 211 VIDPRTGTILQETNCKSHKASKVLFLGNLKMLLSTGnsrwNHRQIALWDQEDlSQPSYSedLDG-SSGVLFPFYDPDTHM 289
Cdd:cd00200   77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSS----RDKTIKVWDVET-GKCLTT--LRGhTDWVNSVAFSPDGTF 149

                        170       180
                 ....*....|....*....|.
gi 528468128 290 LYiAGKGDGNIRYYEISPEKP 310
Cdd:cd00200  150 VA-SSSQDGTIKLWDLRTGKC 169
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 177-321 2.24e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 2.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 177 PVRSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVIDPRTGTilQETNCKSHKAS--KVLFLGNLKMLLSTGNSrwnhRQ 254
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPvrDVAASADGTYLASGSSD----KT 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528468128 255 IALWDQEDLSQPSYsedLDG-SSGVLFPFYDPDTHMLyIAGKGDGNIRYYEISPEKPyvhyLTEYRSH 321
Cdd:cd00200   75 IRLWDLETGECVRT---LTGhTSYVSSVAFSPDGRIL-SSSSRDKTIKVWDVETGKC----LTTLRGH 134
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-213 3.23e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.23e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528468128   175 KNPVRSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVID 213
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
175-213 2.35e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 2.35e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528468128  175 KNPVRSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVID 213
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 84-116 4.44e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.44e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 528468128    84 SGHRGNVLDIKWNHFNDFcIASCSEDATVKIWE 116
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
82-116 2.26e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 2.26e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 528468128   82 KVSGHRGNVLDIKWNHFNDFcIASCSEDATVKIWE 116
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
133-301 5.48e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.12  E-value: 5.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 133 LQGHSRRVGLIEWHPTANNIIFSTGYDYQVMVWKLDVPEQviknpvRSISVHSDVVLSMSFNTDGSKLATSCKDKKIRVI 212
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL------ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468128 213 DPRTGTILQETNCKSHKASKVLFLGNLKMLLSTGnsrwNHRQIALWDQEDLSQP-SYSEDLDGSSGVLFpfyDPDTHMLY 291
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGS----ADGTVRLWDLATGKLLrTLTGHSGAVTSVAF---SPDGKLLA 178

                        170
                 ....*....|
gi 528468128 292 IAGkGDGNIR 301
Cdd:COG2319  179 SGS-DDGTVR 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH