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Conserved domains on  [gi|392348189|ref|XP_003750041|]
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low-density lipoprotein receptor-related protein 8 isoform X7 [Rattus norvegicus]

Protein Classification

LDL receptor domain-containing protein( domain architecture ID 10819330)

Low Density Lipoprotein (LDL) receptor class A domain is a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; similar to Bos taurus CD320 antigen

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 547-587 2.87e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.57  E-value: 2.87e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 392348189  547 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 587
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 44-78 1.69e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 1.69e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 392348189  44 CEEDQFRCRNERCIPSVWRCDEDNDCSDNSDEDDC 78
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 485-526 2.63e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.15  E-value: 2.63e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 392348189   485 VLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRR 526
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 571-613 5.74e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 5.74e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 392348189   571 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 613
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 82-114 4.61e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 4.61e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 392348189    82 TCTDSDFTCDNGHCIPERWKCDGEEECPDGSDE 114
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 256-289 1.27e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.27e-09
                         10        20        30
                 ....*....|....*....|....*....|....
gi 392348189 256 PTTQFTCRSGECIHLGWRCDGDRDCKDKSDEADC 289
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 294-328 4.71e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 4.71e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 392348189 294 CRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGC 328
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 203-235 4.77e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 4.77e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 392348189   203 CPPREFRCGGGgTCIPERWVCDGQFDCEDRSDE 235
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 634-674 4.07e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.85  E-value: 4.07e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 392348189  634 DKVFWTDLENEAIFSANRLNGLEI-SILAENLNNPHDIVIFH 674
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 335-369 2.62e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.62  E-value: 2.62e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 392348189  335 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 369
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 124-160 9.60e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 9.60e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 392348189 124 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 160
Cdd:cd00112    1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
371-401 1.87e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.87e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 392348189   371 DIDECQDPDACSQ--ICVNYKGYFKCECHPGYE 401
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
422-555 1.60e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 422 TNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSahMDKASIPDEQVVLIGEQlhsPEGLAVDW 501
Cdd:COG3391   87 SGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVGAG---PHGIAVDP 161

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 392348189 502 VHKHIYWTDSGNKTVSV-----ATTDGRRRCTLfnRDLSEPRAIAVDPLRGFMYWSDWG 555
Cdd:COG3391  162 DGKRLYVANSGSNTVSVivsviDTATGKVVATI--PVGGGPVGVAVSPDGRRLYVANRG 218
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 692-729 2.07e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.45  E-value: 2.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 392348189  692 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 729
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 547-587 2.87e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.57  E-value: 2.87e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 392348189  547 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 587
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 44-78 1.69e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 1.69e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 392348189  44 CEEDQFRCRNERCIPSVWRCDEDNDCSDNSDEDDC 78
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 485-526 2.63e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.15  E-value: 2.63e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 392348189   485 VLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRR 526
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 571-613 5.74e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 5.74e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 392348189   571 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 613
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 528-570 7.34e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 7.34e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 392348189   528 TLFNRDLSEPRAIAVDPLRGFMYWSDWGfQAKIEKAGLNGADR 570
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 43-75 2.97e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 2.97e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 392348189    43 ECEEDQFRCRNERCIPSVWRCDEDNDCSDNSDE 75
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 82-114 4.61e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 4.61e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 392348189    82 TCTDSDFTCDNGHCIPERWKCDGEEECPDGSDE 114
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 505-544 8.60e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.86  E-value: 8.60e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 392348189  505 HIYWTDSGNK-TVSVATTDGRRRCTLFNRDLSEPRAIAVDP 544
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 256-289 1.27e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.27e-09
                         10        20        30
                 ....*....|....*....|....*....|....
gi 392348189 256 PTTQFTCRSGECIHLGWRCDGDRDCKDKSDEADC 289
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 83-114 2.15e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 2.15e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 392348189  83 CTDSDFTCDNGHCIPERWKCDGEEECPDGSDE 114
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
259-289 2.83e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 2.83e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 392348189  259 QFTCRSGECIHLGWRCDGDRDCKDKSDEADC 289
Cdd:pfam00057   7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 294-328 4.71e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 4.71e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 392348189 294 CRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGC 328
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 203-235 4.77e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 4.77e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 392348189   203 CPPREFRCGGGgTCIPERWVCDGQFDCEDRSDE 235
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
44-78 6.32e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.25  E-value: 6.32e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 392348189   44 CEEDQFRCRNERCIPSVWRCDEDNDCSDNSDEDDC 78
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 203-236 7.25e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 7.25e-09
                         10        20        30
                 ....*....|....*....|....*....|....
gi 392348189 203 CPPREFRCGGGgTCIPERWVCDGQFDCEDRSDEA 236
Cdd:cd00112    1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
293-328 9.35e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 9.35e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 392348189  293 PCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGC 328
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 256-286 3.55e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.94  E-value: 3.55e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 392348189   256 PTTQFTCRSGECIHLGWRCDGDRDCKDKSDE 286
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 634-674 4.07e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.85  E-value: 4.07e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 392348189  634 DKVFWTDLENEAIFSANRLNGLEI-SILAENLNNPHDIVIFH 674
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 490-672 5.83e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.02  E-value: 5.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 490 QLHSPEGLAVDwVHKHIYWTDSGNKTVSVATTDGRRRCT-----LFNRDLSEPRAIAVDPlRGFMYWSDWG------FQA 558
Cdd:cd05819   53 QFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGnhriqkFDP 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 559 K---IEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGNrkMLIFSTDF-----LSHPFGVA 630
Cdd:cd05819  131 DgefLTTFGSGGSGPGQFNG-----PTGVAVD-SDGNIYVADTGNHRIQVFDPDGNF--LTTFGSTGtgpgqFNYPTGIA 202

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 392348189 631 VFED-KVFWTDLENEAIFSANRLNGLEISI-----LAENLNNPHDIVI 672
Cdd:cd05819  203 VDSDgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 294-325 6.77e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 6.77e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 392348189   294 CRENDFQCGDGTCILAIKRCNQERDCLDGSDE 325
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
81-114 1.63e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 1.63e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 392348189   81 RTCTDSDFTCDNGHCIPERWKCDGEEECPDGSDE 114
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 591-633 1.72e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 1.72e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 392348189  591 QRLYWVDSKLHQ-LSSIDFNGGNRKMLIfsTDFLSHPFGVAVFE 633
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 335-369 2.62e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.62  E-value: 2.62e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 392348189  335 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 369
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
203-236 3.75e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 3.75e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 392348189  203 CPPREFRCGGGgTCIPERWVCDGQFDCEDRSDEA 236
Cdd:pfam00057   3 CSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEE 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 124-160 9.60e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 9.60e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 392348189 124 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 160
Cdd:cd00112    1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
503-660 5.49e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.92  E-value: 5.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 503 HKHIYWTDSGNKTVSV-ATTDGRRRCTLfnRDLSEPRAIAVDPLRGFMYWSDWGfQAKIEKagLNGADRQTLvsDNI--- 578
Cdd:COG3391   79 GRRLYVANSGSGRVSViDLATGKVVATI--PVGGGPRGLAVDPDGGRLYVADSG-NGRVSV--IDTATGKVV--ATIpvg 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 579 EWPNGITLDLLSQRLYWVDSKLHQLSSI--DFNGGNRKmLIFSTDFLSHPFGVAVFED--KVFWTDLENEaifSANRLNG 654
Cdd:COG3391  152 AGPHGIAVDPDGKRLYVANSGSNTVSVIvsVIDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANRGSN---TSNGGSN 227


                 ....*.
gi 392348189 655 lEISIL 660
Cdd:COG3391  228 -TVSVI 232
EGF_CA smart00179
Calcium-binding EGF-like domain;
371-401 1.87e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.87e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 392348189   371 DIDECQDPDACSQ--ICVNYKGYFKCECHPGYE 401
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 123-157 4.72e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.08  E-value: 4.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 392348189   123 ECPAEKLSCGptSHKCVPASWRCDGEKDCEGGADE 157
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
124-160 5.01e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.08  E-value: 5.01e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 392348189  124 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 160
Cdd:pfam00057   3 CSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 371-404 6.16e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 6.16e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 392348189 371 DIDECQDPDACS--QICVNYKGYFKCECHPGYEMDT 404
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGRN 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
422-555 1.60e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 422 TNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSahMDKASIPDEQVVLIGEQlhsPEGLAVDW 501
Cdd:COG3391   87 SGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVGAG---PHGIAVDP 161

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 392348189 502 VHKHIYWTDSGNKTVSV-----ATTDGRRRCTLfnRDLSEPRAIAVDPLRGFMYWSDWG 555
Cdd:COG3391  162 DGKRLYVANSGSNTVSVivsviDTATGKVVATI--PVGGGPVGVAVSPDGRRLYVANRG 218
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 440-475 1.69e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 1.69e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 392348189   440 LIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSAHMD 475
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 692-729 2.07e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.45  E-value: 2.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 392348189  692 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 729
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 457-501 8.33e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.21  E-value: 8.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 392348189  457 NRIYWCDLSYR-KIYSAHMDKASipdeQVVLIGEQLHSPEGLAVDW 501
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSD----RKTLFTDDLQHPNAIAVDP 42
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 547-587 2.87e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.57  E-value: 2.87e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 392348189  547 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 587
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 44-78 1.69e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 1.69e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 392348189  44 CEEDQFRCRNERCIPSVWRCDEDNDCSDNSDEDDC 78
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 485-526 2.63e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.15  E-value: 2.63e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 392348189   485 VLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRR 526
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 571-613 5.74e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 5.74e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 392348189   571 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 613
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 528-570 7.34e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 7.34e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 392348189   528 TLFNRDLSEPRAIAVDPLRGFMYWSDWGfQAKIEKAGLNGADR 570
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 43-75 2.97e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 2.97e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 392348189    43 ECEEDQFRCRNERCIPSVWRCDEDNDCSDNSDE 75
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 82-114 4.61e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 4.61e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 392348189    82 TCTDSDFTCDNGHCIPERWKCDGEEECPDGSDE 114
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 505-544 8.60e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.86  E-value: 8.60e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 392348189  505 HIYWTDSGNK-TVSVATTDGRRRCTLFNRDLSEPRAIAVDP 544
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 256-289 1.27e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.27e-09
                         10        20        30
                 ....*....|....*....|....*....|....
gi 392348189 256 PTTQFTCRSGECIHLGWRCDGDRDCKDKSDEADC 289
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 83-114 2.15e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 2.15e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 392348189  83 CTDSDFTCDNGHCIPERWKCDGEEECPDGSDE 114
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
259-289 2.83e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 2.83e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 392348189  259 QFTCRSGECIHLGWRCDGDRDCKDKSDEADC 289
Cdd:pfam00057   7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 294-328 4.71e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 4.71e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 392348189 294 CRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGC 328
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 203-235 4.77e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 4.77e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 392348189   203 CPPREFRCGGGgTCIPERWVCDGQFDCEDRSDE 235
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
44-78 6.32e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.25  E-value: 6.32e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 392348189   44 CEEDQFRCRNERCIPSVWRCDEDNDCSDNSDEDDC 78
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 203-236 7.25e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 7.25e-09
                         10        20        30
                 ....*....|....*....|....*....|....
gi 392348189 203 CPPREFRCGGGgTCIPERWVCDGQFDCEDRSDEA 236
Cdd:cd00112    1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
293-328 9.35e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 9.35e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 392348189  293 PCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGC 328
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 256-286 3.55e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.94  E-value: 3.55e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 392348189   256 PTTQFTCRSGECIHLGWRCDGDRDCKDKSDE 286
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 634-674 4.07e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.85  E-value: 4.07e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 392348189  634 DKVFWTDLENEAIFSANRLNGLEI-SILAENLNNPHDIVIFH 674
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 490-672 5.83e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.02  E-value: 5.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 490 QLHSPEGLAVDwVHKHIYWTDSGNKTVSVATTDGRRRCT-----LFNRDLSEPRAIAVDPlRGFMYWSDWG------FQA 558
Cdd:cd05819   53 QFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGnhriqkFDP 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 559 K---IEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGNrkMLIFSTDF-----LSHPFGVA 630
Cdd:cd05819  131 DgefLTTFGSGGSGPGQFNG-----PTGVAVD-SDGNIYVADTGNHRIQVFDPDGNF--LTTFGSTGtgpgqFNYPTGIA 202

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 392348189 631 VFED-KVFWTDLENEAIFSANRLNGLEISI-----LAENLNNPHDIVI 672
Cdd:cd05819  203 VDSDgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 294-325 6.77e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 6.77e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 392348189   294 CRENDFQCGDGTCILAIKRCNQERDCLDGSDE 325
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
81-114 1.63e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 1.63e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 392348189   81 RTCTDSDFTCDNGHCIPERWKCDGEEECPDGSDE 114
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 591-633 1.72e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 1.72e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 392348189  591 QRLYWVDSKLHQ-LSSIDFNGGNRKMLIfsTDFLSHPFGVAVFE 633
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 335-369 2.62e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.62  E-value: 2.62e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 392348189  335 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 369
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 489-672 2.71e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 53.09  E-value: 2.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 489 EQLHSPEGLAVDwVHKHIYWTDSGNKTVSVATTDGRRRCTL-----FNRDLSEPRAIAVDPlRGFMY-----------WS 552
Cdd:cd05819    5 GELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGNFITSFgsfgsGDGQFNEPAGVAVDS-DGNLYvadtgnhriqkFD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 553 DWGfqAKIEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGnrkmLIF-------STDFLSH 625
Cdd:cd05819   83 PDG--NFLASFGGSGDGDGEFNG-----PRGIAVD-SSGNIYVADTGNHRIQKFDPDGE----FLTtfgsggsGPGQFNG 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 392348189 626 PFGVAVF-EDKVFWTDLENEAI--FSAnrlNGLEISILAEN------LNNPHDIVI 672
Cdd:cd05819  151 PTGVAVDsDGNIYVADTGNHRIqvFDP---DGNFLTTFGSTgtgpgqFNYPTGIAV 203
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
203-236 3.75e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 3.75e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 392348189  203 CPPREFRCGGGgTCIPERWVCDGQFDCEDRSDEA 236
Cdd:pfam00057   3 CSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEE 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 124-160 9.60e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 9.60e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 392348189 124 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 160
Cdd:cd00112    1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
503-660 5.49e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.92  E-value: 5.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 503 HKHIYWTDSGNKTVSV-ATTDGRRRCTLfnRDLSEPRAIAVDPLRGFMYWSDWGfQAKIEKagLNGADRQTLvsDNI--- 578
Cdd:COG3391   79 GRRLYVANSGSGRVSViDLATGKVVATI--PVGGGPRGLAVDPDGGRLYVADSG-NGRVSV--IDTATGKVV--ATIpvg 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 579 EWPNGITLDLLSQRLYWVDSKLHQLSSI--DFNGGNRKmLIFSTDFLSHPFGVAVFED--KVFWTDLENEaifSANRLNG 654
Cdd:COG3391  152 AGPHGIAVDPDGKRLYVANSGSNTVSVIvsVIDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANRGSN---TSNGGSN 227


                 ....*.
gi 392348189 655 lEISIL 660
Cdd:COG3391  228 -TVSVI 232
EGF_CA smart00179
Calcium-binding EGF-like domain;
371-401 1.87e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.87e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 392348189   371 DIDECQDPDACSQ--ICVNYKGYFKCECHPGYE 401
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 123-157 4.72e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.08  E-value: 4.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 392348189   123 ECPAEKLSCGptSHKCVPASWRCDGEKDCEGGADE 157
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
124-160 5.01e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.08  E-value: 5.01e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 392348189  124 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 160
Cdd:pfam00057   3 CSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 371-404 6.16e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 6.16e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 392348189 371 DIDECQDPDACS--QICVNYKGYFKCECHPGYEMDT 404
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGRN 36
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 411-601 8.02e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 45.66  E-value: 8.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 411 AVAGRSPSLIF---TNRHEVRRIDLVKRDYSRLIP----MLKNVVALDVEVDtNRIYWCDLSYRKIYsaHMDkasiPDEQ 483
Cdd:cd14962   16 GVAADGRGRIYvadTGRGAVFVFDLPNGKVFVIGNagpnRFVSPIGVAIDAN-GNLYVSDAELGKVF--VFD----RDGK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 484 VV-LIGE--QLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRRCTLFNRD-----LSEPRAIAVDPlRGFMYWSDwG 555
Cdd:cd14962   89 FLrAIGAgaLFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRGsgpgeFNLPTDLAVDR-DGNLYVTD-T 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 392348189 556 FQAKIEKAGLNGADRQT-----LVSDNIEWPNGITLDlLSQRLYWVDSKLH 601
Cdd:cd14962  167 MNFRVQIFDADGKFLRSfgergDGPGSFARPKGIAVD-SEGNIYVVDAAFD 216
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 489-640 1.05e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.00  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 489 EQLHSPEGLAVDwVHKHIYWTDSGNKTVSVATTDGRRRcTLF------NRDLSEPRAIAVDPlRGFMYWSDWG------- 555
Cdd:cd05819   99 GEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFL-TTFgsggsgPGQFNGPTGVAVDS-DGNIYVADTGnhriqvf 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 556 -----FQAKIEKAGLNGADRQTlvsdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNG------GNRkmlIFSTDFLS 624
Cdd:cd05819  176 dpdgnFLTTFGSTGTGPGQFNY--------PTGIAVD-SDGNIYVADSGNNRVQVFDPDGagfggnGNF---LGSDGQFN 243

                        170
                 ....*....|....*..
gi 392348189 625 HPFGVAVFED-KVFWTD 640
Cdd:cd05819  244 RPSGLAVDSDgNLYVAD 260
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
422-555 1.60e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 422 TNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSahMDKASIPDEQVVLIGEQlhsPEGLAVDW 501
Cdd:COG3391   87 SGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVGAG---PHGIAVDP 161

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 392348189 502 VHKHIYWTDSGNKTVSV-----ATTDGRRRCTLfnRDLSEPRAIAVDPLRGFMYWSDWG 555
Cdd:COG3391  162 DGKRLYVANSGSNTVSVivsviDTATGKVVATI--PVGGGPVGVAVSPDGRRLYVANRG 218
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 440-475 1.69e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 1.69e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 392348189   440 LIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSAHMD 475
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 457-631 2.03e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.11  E-value: 2.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 457 NRIYWCDLSYRKIYSAHMDKASIpdeQVVLIGEQLHSpeGLAVD-----WVHKH---IYWTDSGNKTVSVATTDGRRRCT 528
Cdd:COG3386   19 GRLYWVDIPGGRIHRYDPDGGAV---EVFAEPSGRPN--GLAFDpdgrlLVADHgrgLVRFDPADGEVTVLADEYGKPLN 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 529 LFNrDLsepraiAVDPlRGFMYWSDwgFQAKIEKAGL---NGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSS 605
Cdd:COG3386   94 RPN-DG------VVDP-DGRLYFTD--MGEYLPTGALyrvDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYR 163

                        170       180       190
                 ....*....|....*....|....*....|
gi 392348189 606 IDFNG----GNRKMLIFSTDFLSHPFGVAV 631
Cdd:COG3386  164 FDLDAdgtlGNRRVFADLPDGPGGPDGLAV 193
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 490-646 5.60e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.04  E-value: 5.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 490 QLHSPEGLAVDWVHkHIYWTDSGNKTVSVATTDGRRRCTLFNR-----DLSEPRAIAVDPLrGFMYWSD-WGFqaKIEKA 563
Cdd:cd14956   11 QFKDPRGIAVDADD-NVYVADARNGRIQVFDKDGTFLRRFGTTgdgpgQFGRPRGLAVDKD-GWLYVADyWGD--RIQVF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 564 GLNGADRQTL-VSDNIE----WPNGITLDllSQRLYWVdsklhqlssIDFngGNRKMLIFSTD--FLS------------ 624
Cdd:cd14956   87 TLTGELQTIGgSSGSGPgqfnAPRGVAVD--ADGNLYV---------ADF--GNQRIQKFDPDgsFLRqwggtgiepgsf 153

                        170       180
                 ....*....|....*....|....
gi 392348189 625 -HPFGVAVFEDKVFW-TDLENEAI 646
Cdd:cd14956  154 nYPRGVAVDPDGTLYvADTYNDRI 177
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 481-643 8.07e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 42.19  E-value: 8.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 481 DEQVVLIGEQLHSPEGLAVDwVHKHIYWTDSGNKTVSVATTDGRRRCTLFNRDLSEPRAIAVDPLRGFmYWSDWGFQAKI 560
Cdd:cd14952   41 TTQTVLPFTGLYQPQGVAVD-AAGTVYVTDFGNNRVLKLAAGSTTQTVLPFTGLNDPTGVAVDAAGNV-YVADTGNNRVL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 561 EKAGlnGADRQTLVS-DNIEWPNGITLDlLSQRLYWVDSklhqlssidfnGGNRKM-----------LIFsTDfLSHPFG 628
Cdd:cd14952  119 KLAA--GSNTQTVLPfTGLSNPDGVAVD-GAGNVYVTDT-----------GNNRVLklaagsttqtvLPF-TG-LNSPSG 182

                        170
                 ....*....|....*.
gi 392348189 629 VAV-FEDKVFWTDLEN 643
Cdd:cd14952  183 VAVdTAGNVYVTDHGN 198
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 491-675 8.44e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 42.28  E-value: 8.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 491 LHSPEGLAVDWvhKHIYWTDSGNKTVSVATTDGRRRCTLFNRD-----LSEPRAIAVDPlRGFMYWSDWGFQaKIEKAGL 565
Cdd:cd14963    9 LNKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPGtgpgeFKYPYGIAVDS-DGNIYVADLYNG-RIQVFDP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 566 NGADRQTLVSD----NIEWPNGITLDllSQRLYWVDSKLHQLSSIDFNGgnRKMLIFST--DF---LSHPFGVAVFEDK- 635
Cdd:cd14963   85 DGKFLKYFPEKkdrvKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEG--KLLLEFGKpgSEpgeLSYPNGIAVDEDGn 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392348189 636 VFWTDLENEAI--FSAN-----RLNGLeiSILAENLNNP------------------HDIVIFHE 675
Cdd:cd14963  161 IYVADSGNGRIqvFDKNgkfikELNGS--PDGKSGFVNPrgiavdpdgnlyvvdnlsHRVYVFDE 223
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 692-729 2.07e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.45  E-value: 2.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 392348189  692 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 729
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
447-555 4.52e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.68  E-value: 4.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392348189 447 VVALDVEVDTNRIYWCDlsyrkIYSAHMDKASIPDEQVVLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSV-ATTDGRR 525
Cdd:COG3391   70 ADGADAGADGRRLYVAN-----SGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSViDTATGKV 144

                         90       100       110
                 ....*....|....*....|....*....|
gi 392348189 526 RCTLFNRDlsEPRAIAVDPLRGFMYWSDWG 555
Cdd:COG3391  145 VATIPVGA--GPHGIAVDPDGKRLYVANSG 172
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 457-501 8.33e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.21  E-value: 8.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 392348189  457 NRIYWCDLSYR-KIYSAHMDKASipdeQVVLIGEQLHSPEGLAVDW 501
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSD----RKTLFTDDLQHPNAIAVDP 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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