NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|357126938|ref|XP_003565144|]
View 

protein phosphatase 1 regulatory subunit SDS22 [Brachypodium distachyon]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
12-233 2.60e-31

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 2.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  12 DAGSGATALDLSHRTFSDVSCLGSFKSLERLDLGYNclvtlEGLSSCVNLKWLSVIENKLVSL-KGVEGLTKLQVLNAGK 90
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  91 NKLTKI-DEVKSLTTLGALILNDNNISAICK-LDRHHQLNTLVLSKNPVGTIGDSLVNAKSLKKLSMSHCQIEDIGSSLV 168
Cdd:COG4886  146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLA 225

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 357126938 169 ACVELKELRLAHNKISKIPSdLAKNVKILNLDLGNNlieRVSDLKALAELRFLRNLNLQGNPIAE 233
Cdd:COG4886  226 NLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNN---QLTDLPPLANLTNLKTLDLSNNQLTD 286
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
12-233 2.60e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 2.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  12 DAGSGATALDLSHRTFSDVSCLGSFKSLERLDLGYNclvtlEGLSSCVNLKWLSVIENKLVSL-KGVEGLTKLQVLNAGK 90
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  91 NKLTKI-DEVKSLTTLGALILNDNNISAICK-LDRHHQLNTLVLSKNPVGTIGDSLVNAKSLKKLSMSHCQIEDIGSSLV 168
Cdd:COG4886  146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLA 225

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 357126938 169 ACVELKELRLAHNKISKIPSdLAKNVKILNLDLGNNlieRVSDLKALAELRFLRNLNLQGNPIAE 233
Cdd:COG4886  226 NLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNN---QLTDLPPLANLTNLKTLDLSNNQLTD 286
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 49-267 3.63e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 91.39  E-value: 3.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  49 LVTLEGLSSCVNLKWLSVIENKLVSLKGVEGLTKLQVLNAGKNKLTKIDEVKSLTTLGALILNDNNISAICKLDRHHQLN 128
Cdd:cd21340   14 ITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938 129 TLVLSKN--PVGTI----GDSLVN-AKSLKKLSMSHCQIEDIgSSLVACVELKELRLAHNKISKipsdlaknvkilnldl 201
Cdd:cd21340   94 ELHIENQrlPPGEKltfdPRSLAAlSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISD---------------- 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 357126938 202 gnnlIERVSDLkaLAELRFLRNLNLQGNPIAEKDSLVKKVMKTVPTLRIFNAKPIeassqTDNSRK 267
Cdd:cd21340  157 ----LEELLDL--LSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEI-----TDTERQ 211
LRR_8 pfam13855
Leucine rich repeat;
172-231 5.97e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 5.97e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 357126938  172 ELKELRLAHNKISKIPSDLAKNVKILN-LDLGNNLIERVSDlKALAELRFLRNLNLQGNPI 231
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKvLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 18-204 1.51e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  18 TALDLSHRTFSD--VSCLGSFKSLERLDLGYNclvTLEG-----LSSCVNLKWLSVIENKLvSLKGVEGLTKLQV---LN 87
Cdd:PLN00113 359 TVLDLSTNNLTGeiPEGLCSSGNLFKLILFSN---SLEGeipksLGACRSLRRVRLQDNSF-SGELPSEFTKLPLvyfLD 434

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  88 AGKNKLT-KIDEVK-SLTTLGALILNDNNISA-ICKLDRHHQLNTLVLSKNPV-GTIGDSLVNAKSLKKLSMSHCQIE-D 162
Cdd:PLN00113 435 ISNNNLQgRINSRKwDMPSLQMLSLARNKFFGgLPDSFGSKRLENLDLSRNQFsGAVPRKLGSLSELMQLKLSENKLSgE 514

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 357126938 163 IGSSLVACVELKELRLAHNKIS-KIPSDLAKNVKILNLDLGNN 204
Cdd:PLN00113 515 IPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQN 557
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
12-233 2.60e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 2.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  12 DAGSGATALDLSHRTFSDVSCLGSFKSLERLDLGYNclvtlEGLSSCVNLKWLSVIENKLVSL-KGVEGLTKLQVLNAGK 90
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  91 NKLTKI-DEVKSLTTLGALILNDNNISAICK-LDRHHQLNTLVLSKNPVGTIGDSLVNAKSLKKLSMSHCQIEDIGSSLV 168
Cdd:COG4886  146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLA 225

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 357126938 169 ACVELKELRLAHNKISKIPSdLAKNVKILNLDLGNNlieRVSDLKALAELRFLRNLNLQGNPIAE 233
Cdd:COG4886  226 NLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNN---QLTDLPPLANLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-237 7.49e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 7.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  39 LERLDLGYNCLVTLEGLSSCVNLKWLSVIENKLVSLKGVEGLTKLQVLNAGKNKLTKIDEVKSLTTLGALILNDNNISAI 118
Cdd:COG4886   49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938 119 CK-LDRHHQLNTLVLSKNPVGTIGDSLVNAKSLKKLSMSHCQIEDIGSSLVACVELKELRLAHNKISKIPSDLAKNVKIL 197
Cdd:COG4886  129 PEeLANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLE 208

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 357126938 198 NLDLGNNLIERVSDlkALAELRFLRNLNLQGNPIAEKDSL 237
Cdd:COG4886  209 ELDLSGNQLTDLPE--PLANLTNLETLDLSNNQLTDLPEL 246
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 49-267 3.63e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 91.39  E-value: 3.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  49 LVTLEGLSSCVNLKWLSVIENKLVSLKGVEGLTKLQVLNAGKNKLTKIDEVKSLTTLGALILNDNNISAICKLDRHHQLN 128
Cdd:cd21340   14 ITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938 129 TLVLSKN--PVGTI----GDSLVN-AKSLKKLSMSHCQIEDIgSSLVACVELKELRLAHNKISKipsdlaknvkilnldl 201
Cdd:cd21340   94 ELHIENQrlPPGEKltfdPRSLAAlSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISD---------------- 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 357126938 202 gnnlIERVSDLkaLAELRFLRNLNLQGNPIAEKDSLVKKVMKTVPTLRIFNAKPIeassqTDNSRK 267
Cdd:cd21340  157 ----LEELLDL--LSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEI-----TDTERQ 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-233 4.47e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.92  E-value: 4.47e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  15 SGATALDLSHRTFSDVSCLGSFKSLERLDLGYNCLVTLEGLSSCVNLKWLSVIENKLVSLKGVEGLTKLQVLNAGKNKLT 94
Cdd:COG4886    8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  95 KIDEVKSLTTLGALILNDNNISAICKldrhhQLNTLVLSKNPVGTIGDSLVNAKSLKKLSMSHCQIEDIGSSLVACVELK 174
Cdd:COG4886   88 GLTDLGDLTNLTELDLSGNEELSNLT-----NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLK 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 357126938 175 ELRLAHNKISKIPSDLAKNVKILNLDLGNNLIERVSDlkALAELRFLRNLNLQGNPIAE 233
Cdd:COG4886  163 SLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGNQLTD 219
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
20-223 2.88e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 2.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  20 LDLSHRTFSDVSC-LGSFKSLERLDLGYNCLVTL-EGLSSCVNLKWLSVIENKLVSLKGVEGLTKLQVLNAGKNKLTKID 97
Cdd:COG4886  187 LDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  98 EVKSLTTLGALILNDNNISAIC-----KLDRHHQLNTLVLSKNPVGTIGDSLVNAKSLKKLSMSHCQIEDIGSSLVACVE 172
Cdd:COG4886  267 PLANLTNLKTLDLSNNQLTDLKlkeleLLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 357126938 173 LKELRLAHNKISKIPSDLAKNVKILNLDLGNNLIERVSDLKALAELRFLRN 223
Cdd:COG4886  347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR_8 pfam13855
Leucine rich repeat;
172-231 5.97e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 5.97e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 357126938  172 ELKELRLAHNKISKIPSDLAKNVKILN-LDLGNNLIERVSDlKALAELRFLRNLNLQGNPI 231
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKvLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 103-252 2.27e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.87  E-value: 2.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938 103 TTLGALILNDNNI-----SAICK-LDRHHQLNTLVLSKNPVG-----TIGDSLVNAKSLKKLSMSHCQIEDIGSSLVA-- 169
Cdd:COG5238  208 TTVTTLWLKRNPIgdegaEILAEaLKGNKSLTTLDLSNNQIGdegviALAEALKNNTTVETLYLSGNQIGAEGAIALAka 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938 170 ---CVELKELRLAHNKISK-----IPSDLAKNVKILNLDLGNNLI---ERVSDLKALAELRFLRNLNLQGNPIAEKD-SL 237
Cdd:COG5238  288 lqgNTTLTSLDLSVNRIGDegaiaLAEGLQGNKTLHTLNLAYNGIgaqGAIALAKALQENTTLHSLDLSDNQIGDEGaIA 367

                        170
                 ....*....|....*
gi 357126938 238 VKKVMKTVPTLRIFN 252
Cdd:COG5238  368 LAKYLEGNTTLRELN 382
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 11-206 1.19e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  11 RDAGSGATALDLSHRTFSDVSClgsfkSLERLDLGYN------CLVTLEGLSSCVNLKWLSVIENKLvslkGVEGLTKLQ 84
Cdd:cd00116  116 NNNGLGDRGLRLLAKGLKDLPP-----ALEKLVLGRNrlegasCEALAKALRANRDLKELNLANNGI----GDAGIRALA 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  85 VLNAGKNKLTKIDevkslttLGALILNDNNISAICKLDRHH-QLNTLVLSKNPVGTIGDS------LVNAKSLKKLSMSH 157
Cdd:cd00116  187 EGLKANCNLEVLD-------LNNNGLTDEGASALAETLASLkSLEVLNLGDNNLTDAGAAalasalLSPNISLLTLSLSC 259

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938 158 CQIEDIGSSLVACV-----ELKELRLAHNKISKIPSDL------AKNVKILNLDLGNNLI 206
Cdd:cd00116  260 NDITDDGAKDLAEVlaekeSLLELDLRGNKFGEEGAQLlaesllEPGNELESLWVKDDSF 319
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 18-204 1.51e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  18 TALDLSHRTFSD--VSCLGSFKSLERLDLGYNclvTLEG-----LSSCVNLKWLSVIENKLvSLKGVEGLTKLQV---LN 87
Cdd:PLN00113 359 TVLDLSTNNLTGeiPEGLCSSGNLFKLILFSN---SLEGeipksLGACRSLRRVRLQDNSF-SGELPSEFTKLPLvyfLD 434

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  88 AGKNKLT-KIDEVK-SLTTLGALILNDNNISA-ICKLDRHHQLNTLVLSKNPV-GTIGDSLVNAKSLKKLSMSHCQIE-D 162
Cdd:PLN00113 435 ISNNNLQgRINSRKwDMPSLQMLSLARNKFFGgLPDSFGSKRLENLDLSRNQFsGAVPRKLGSLSELMQLKLSENKLSgE 514

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 357126938 163 IGSSLVACVELKELRLAHNKIS-KIPSDLAKNVKILNLDLGNN 204
Cdd:PLN00113 515 IPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQN 557
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
18-146 1.88e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  18 TALDLSHRTFSDVSCLGSFKSLERLDLGYNCLVTLEGLSSCVNLKWLSVIENKL--VSLKGVEGLTKLQVLNAGKNKLTK 95
Cdd:COG4886  231 ETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLtdLKLKELELLLGLNSLLLLLLLLNL 310

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 357126938  96 IDEVKSLTTLGALILNDNNISAICKLDRHHQLNTLVLSKNPVGTIGDSLVN 146
Cdd:COG4886  311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 28-249 8.43e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 8.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  28 SDVSCLGSFKSLERLDLGYNCLvtLEGLSSCVNLKWLSVIENKLvSLKGVEGLTKLQvlnagknkltkidevkSLTTLGA 107
Cdd:cd00116   52 SLKELCLSLNETGRIPRGLQSL--LQGLTKGCGLQELDLSDNAL-GPDGCGVLESLL----------------RSSSLQE 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938 108 LILNDNNisaickldrhhqlntlvLSKNPVGTIGDSLV-NAKSLKKLSMSHCQI-----EDIGSSLVACVELKELRLAHN 181
Cdd:cd00116  113 LKLNNNG-----------------LGDRGLRLLAKGLKdLPPALEKLVLGRNRLegascEALAKALRANRDLKELNLANN 175

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 357126938 182 KIS-----KIPSDLAKNVKILNLDLGNNLIER--VSDL-KALAELRFLRNLNLQGNPIAEKD--SLVKKVMKTVPTLR 249
Cdd:cd00116  176 GIGdagirALAEGLKANCNLEVLDLNNNGLTDegASALaETLASLKSLEVLNLGDNNLTDAGaaALASALLSPNISLL 253
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 15-229 1.66e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  15 SGATALDLSHRTFSD--VSCLGSFKSLERLDLGYNCLV-----------TLEGLSSCVN---------------LKWLSV 66
Cdd:PLN00113 140 PNLETLDLSNNMLSGeiPNDIGSFSSLKVLDLGGNVLVgkipnsltnltSLEFLTLASNqlvgqiprelgqmksLKWIYL 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  67 IEN-----------KLVSLKGVE---------------GLTKLQVLNAGKNKLTKI--DEVKSLTTLGALILNDNNIS-- 116
Cdd:PLN00113 220 GYNnlsgeipyeigGLTSLNHLDlvynnltgpipsslgNLKNLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSLSge 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938 117 ---------------------------AICKLDR---------------------HHQLNTLVLSKNPV-GTIGDSLVNA 147
Cdd:PLN00113 300 ipelviqlqnleilhlfsnnftgkipvALTSLPRlqvlqlwsnkfsgeipknlgkHNNLTVLDLSTNNLtGEIPEGLCSS 379

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938 148 KSLKKLSMSHCQIED-IGSSLVACVELKELRLAHNKIS-KIPSDLAKNVKILNLDLG-NNLIERVSDLKalAELRFLRNL 224
Cdd:PLN00113 380 GNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISnNNLQGRINSRK--WDMPSLQML 457


                 ....*
gi 357126938 225 NLQGN 229
Cdd:PLN00113 458 SLARN 462
LRR_9 pfam14580
Leucine-rich repeat;
173-257 8.43e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.13  E-value: 8.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  173 LKELRLAHNKISKIPSDLAKNVKILN-LDLGNNLIERVSDLKALAELRFLRNLNLQGNPIAEKDSLVKKVMKTVPTLRIF 251
Cdd:pfam14580  66 LKTLLLNNNRICRIGEGLGEALPNLTeLILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLL 145


                  ....*.
gi 357126938  252 NAKPIE 257
Cdd:pfam14580 146 DFRKVK 151
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 22-158 2.16e-03

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 39.62  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  22 LSHRTFSDVSCLGS--FKSLERLDLgYNC---LVTLEGLSSCVNLKWLSVIENKLVSLKGVEGLTK----LQVLNagknk 92
Cdd:cd09293   11 LGQITQSNISQLLRilHSGLEWLEL-YMCpisDPPLDQLSNCNKLKKLILPGSKLIDDEGLIALAQscpnLQVLD----- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357126938  93 LTKIDEV------------KSLTTL-------GALIlNDNNISAICKLDRhhQLNTLVLSKNPV---GTIGDSLVNAKSL 150
Cdd:cd09293   85 LRACENItdsgivalatncPKLQTInlgrhrnGHLI-TDVSLSALGKNCT--FLQTVGFAGCDVtdkGVWELASGCSKSL 161


                 ....*...
gi 357126938 151 KKLSMSHC 158
Cdd:cd09293  162 ERLSLNNC 169
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 173-213 2.69e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 2.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 357126938  173 LKELRLAHNKISKIPSDLA-KNVKILNLdLGNNLIERVSDLK 213
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKlPNLETLDL-SGNNKITDLSDLA 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 148-192 6.73e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 6.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 357126938  148 KSLKKLSMSHCQIEDIgSSLVACVELKELRLAHN-KISKIpSDLAK 192
Cdd:pfam12799   1 PNLEVLDLSNNQITDI-PPLAKLPNLETLDLSGNnKITDL-SDLAN 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH